MD4626B1 - Derivaţi de tamoxifen pentru tratamentul afecţiunilor neoplazice, în special cu nivel înalt de proteină HER2 - Google Patents

Derivaţi de tamoxifen pentru tratamentul afecţiunilor neoplazice, în special cu nivel înalt de proteină HER2 Download PDF

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Publication number
MD4626B1
MD4626B1 MDA20150117A MD20150117A MD4626B1 MD 4626 B1 MD4626 B1 MD 4626B1 MD A20150117 A MDA20150117 A MD A20150117A MD 20150117 A MD20150117 A MD 20150117A MD 4626 B1 MD4626 B1 MD 4626B1
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MD
Moldova
Prior art keywords
tamoxifen
treatment
derivatives
her2 protein
triphenylphosphonium
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Application number
MDA20150117A
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English (en)
Russian (ru)
Other versions
MD4626C1 (ro
MD20150117A2 (ro
Inventor
Ян Штурса
Лукаш Вернер
Иржи Неужиль
Original Assignee
Smart Brain s.r.o.
Biotechnologicky Ustav Av Cr V.V0
Иржи Неужиль
Kkcg Ag
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50677895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4626(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CZ2013-308A external-priority patent/CZ304553B6/cs
Priority claimed from CZ2014-66A external-priority patent/CZ305571B6/cs
Application filed by Smart Brain s.r.o., Biotechnologicky Ustav Av Cr V.V0, Иржи Неужиль, Kkcg Ag filed Critical Smart Brain s.r.o.
Publication of MD20150117A2 publication Critical patent/MD20150117A2/ro
Publication of MD4626B1 publication Critical patent/MD4626B1/ro
Publication of MD4626C1 publication Critical patent/MD4626C1/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5449—Polyphosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/008—Dyes containing a substituent, which contains a silicium atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)

Abstract

Prezenta invenţie se referă la noi izomeri E/Z direcţionaţi mitocondrial ai derivaţilor de trifenilfosfoniu alifatic ai tamoxifenului, în care lanţul alifatic este alchil sau alchenil, şi la sărurile aminice terţiare corespunzătoare ale acestora, şi/sau la amestecurile acestora (MitoTax). Derivaţii de alchil trifenilfosfoniu ai tamoxifenului au formula generală (I):I,în care n = 8…12 şi Z este selectat dintr-o grupă de săruri organice sau anorganice.Derivaţii de alchenil trifenilfosfoniu ai tamoxifenului au formula generală IA:IA,în care n = 6…10 şi Z are semnificaţiile definite mai sus.Aceşti compuşi sunt aplicabili pentru tratamentul bolilor neoplazice, în special al celor cu niveluri înalte de proteină HER2. Medicamentul pentru tratamentul bolilor neoplazice, conform prezentei invenţii, conţine cel puţin un izomer E/Z al derivaţilor de trifenilfosfoniu alifatic ai tamoxifenului cu formula generală (I) şi/sau IA, sau sărurile lor corespunzătoare ale aminelor terţiare.
MD20150117A 2013-04-24 2014-04-07 Derivaţi de tamoxifen pentru tratamentul afecţiunilor neoplazice, în special cu nivel înalt de proteină HER2 MD4626C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ2013-308A CZ304553B6 (cs) 2013-04-24 2013-04-24 Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2
CZ2014-66A CZ305571B6 (cs) 2014-01-29 2014-01-29 Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2
PCT/CZ2014/000035 WO2014173374A1 (en) 2013-04-24 2014-04-07 Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level

Publications (3)

Publication Number Publication Date
MD20150117A2 MD20150117A2 (ro) 2016-08-31
MD4626B1 true MD4626B1 (ro) 2019-04-30
MD4626C1 MD4626C1 (ro) 2019-11-30

Family

ID=50677895

Family Applications (1)

Application Number Title Priority Date Filing Date
MD20150117A MD4626C1 (ro) 2013-04-24 2014-04-07 Derivaţi de tamoxifen pentru tratamentul afecţiunilor neoplazice, în special cu nivel înalt de proteină HER2

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US (1) US9896466B2 (ro)
EP (1) EP2989110B1 (ro)
JP (1) JP6375091B2 (ro)
KR (1) KR101764991B1 (ro)
CN (1) CN105452265B (ro)
AU (1) AU2014256546B2 (ro)
CA (1) CA2909994C (ro)
CY (1) CY1120821T1 (ro)
DK (1) DK2989110T3 (ro)
EA (1) EA029881B1 (ro)
ES (1) ES2699099T3 (ro)
GE (2) GEAP201813996A (ro)
HR (1) HRP20181872T1 (ro)
HU (1) HUE042239T2 (ro)
MD (1) MD4626C1 (ro)
NZ (1) NZ713589A (ro)
PL (1) PL2989110T3 (ro)
PT (1) PT2989110T (ro)
SI (1) SI2989110T1 (ro)
UA (1) UA116469C2 (ro)
WO (1) WO2014173374A1 (ro)

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EA033155B1 (ru) * 2015-07-03 2019-09-30 Байер Кропсайенс Акциенгезельшафт Гербицидно активные производные n-(тетразол-5-ил)арилкарбоксамида
EP3317272B1 (de) * 2015-07-03 2019-07-24 Bayer CropScience Aktiengesellschaft Herbizid wirksame n-(1,3,4-oxadiazol-2-yl)arylcarboxamid-derivate
WO2018013559A1 (en) * 2016-07-12 2018-01-18 Accutar Biotechnology Inc. Novel compounds and uses thereof
AU2017312499B2 (en) 2016-08-19 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
EP3330274A1 (en) * 2016-12-01 2018-06-06 Springtide Ventures s.r.o. Compounds for treatment of senescence-related disorders
US11229657B2 (en) 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
EP3612187B1 (en) 2017-04-21 2022-04-13 Lunella Biotech, Inc. Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
CU20190092A7 (es) 2017-05-19 2020-10-20 Lunella Biotech Inc Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas
JP2021500374A (ja) 2017-10-24 2021-01-07 ルネラ・バイオテック・インコーポレーテッド 標的フラビン含有酵素がミトコンドリア呼吸を阻害することにより癌幹細胞（ｃｓｃｓ）を排除するミトフラボスチン
CN111971040B (zh) 2017-11-24 2022-05-27 卢内拉生物技术有限公司 用于根除癌症干细胞的三苯基鏻衍生物化合物
EP3717015A4 (en) 2017-12-01 2021-07-28 Lunella Biotech, Inc. REPURPOSCINS: TARGET MITOCHONDRIAL BIOGENESIS INHIBITORS TO ERADICATE CARCINOUS STEM CELLS
WO2019113210A1 (en) 2017-12-05 2019-06-13 Anthos Partners, Lp Phosphonium-based ionic drug conjugates
EP3728300A4 (en) 2017-12-20 2021-08-11 Lunella Biotech, Inc. TARGETING OF MITOCHONDRIAL FISSION BY MDIVI-1 DERIVATIVES
CN114025769A (zh) * 2019-04-16 2022-02-08 卢内拉生物技术有限公司 用于靶向线粒体和抗癌治疗的烷基-tpp化合物
EP3753944A1 (en) 2019-06-17 2020-12-23 Institute Of Biotechnology Cas, V.V.I. 3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments

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JP3635708B2 (ja) * 1995-03-06 2005-04-06 出光興産株式会社 有機エレクトロルミネッセンス素子
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CA2573456A1 (en) * 2004-07-13 2006-01-19 Eleonore Froehlich Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers
JP5616798B2 (ja) * 2008-03-14 2014-10-29 スティーブン・ジョン・ラルフＳｔｅｐｈｅｎ Ｊｏｈｎ ＲＡＬＰＨ ミトコンドリア由来の抗ガン化合物
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Also Published As

Publication number Publication date
JP6375091B2 (ja) 2018-08-15
EP2989110B1 (en) 2018-08-08
US20160075726A1 (en) 2016-03-17
EP2989110A1 (en) 2016-03-02
GEAP201813996A (en) 2018-03-12
PT2989110T (pt) 2018-11-15
JP2016522179A (ja) 2016-07-28
US9896466B2 (en) 2018-02-20
CA2909994C (en) 2018-06-26
CA2909994A1 (en) 2014-10-30
NZ713589A (en) 2017-12-22
HRP20181872T1 (hr) 2019-02-08
DK2989110T3 (en) 2018-12-03
CN105452265B (zh) 2017-05-10
CN105452265A (zh) 2016-03-30
KR20150144756A (ko) 2015-12-28
CY1120821T1 (el) 2019-12-11
PL2989110T3 (pl) 2019-03-29
EA201591918A1 (ru) 2016-02-29
MD4626C1 (ro) 2019-11-30
AU2014256546A1 (en) 2015-11-12
UA116469C2 (uk) 2018-03-26
AU2014256546B2 (en) 2017-03-30
KR101764991B1 (ko) 2017-08-10
HUE042239T2 (hu) 2019-06-28
EA029881B1 (ru) 2018-05-31
ES2699099T3 (es) 2019-02-07
HK1216317A1 (zh) 2016-11-04
GEP20186868B (en) 2018-06-25
WO2014173374A1 (en) 2014-10-30
SI2989110T1 (sl) 2019-01-31
MD20150117A2 (ro) 2016-08-31

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