ATE130293T1 - Tamoxifenderivate mit hoher affinität und ihre verwendung. - Google Patents
Tamoxifenderivate mit hoher affinität und ihre verwendung.Info
- Publication number
- ATE130293T1 ATE130293T1 AT91919917T AT91919917T ATE130293T1 AT E130293 T1 ATE130293 T1 AT E130293T1 AT 91919917 T AT91919917 T AT 91919917T AT 91919917 T AT91919917 T AT 91919917T AT E130293 T1 ATE130293 T1 AT E130293T1
- Authority
- AT
- Austria
- Prior art keywords
- tamoxifen
- derivatives
- tamoxifen derivatives
- estrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/589,928 US5219548A (en) | 1990-10-01 | 1990-10-01 | High affinity halogenated-tamoxifen derivatives and uses thereof |
| US07/722,322 US5192525A (en) | 1990-10-01 | 1991-06-28 | High affinity tamoxifen derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE130293T1 true ATE130293T1 (de) | 1995-12-15 |
Family
ID=27080697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91919917T ATE130293T1 (de) | 1990-10-01 | 1991-09-27 | Tamoxifenderivate mit hoher affinität und ihre verwendung. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0551434B1 (de) |
| JP (1) | JPH06504522A (de) |
| AT (1) | ATE130293T1 (de) |
| AU (1) | AU664161B2 (de) |
| CA (1) | CA2092996A1 (de) |
| DE (1) | DE69114719T2 (de) |
| WO (1) | WO1992006068A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491173A (en) * | 1982-06-25 | 1996-02-13 | Orion-Yhtyma Oy | Tri-phenyl alkene derivatives and their preparation and use |
| ATE406909T1 (de) * | 1993-05-13 | 2008-09-15 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
| US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
| US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| US6083990A (en) | 1997-04-02 | 2000-07-04 | Pharmos Corporation | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones |
| EE200000077A (et) | 1997-08-15 | 2000-12-15 | Duke University | Östrogeenist sõltuvate haiguste ja häirete vältimise ja ravi meetod |
| TW593256B (en) | 1999-11-16 | 2004-06-21 | Hormos Medical Oy Ltd | Triphenylalkene derivatives and their use as selective estrogen receptor modulators |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| JP2006528648A (ja) * | 2003-07-24 | 2006-12-21 | ザ クイーンズ メディカル センター | アルキル化剤の調製及び使用 |
| KR101505884B1 (ko) | 2006-05-22 | 2015-03-25 | 호르모스 메디칼 리미티드 | 만성 비세균성 전립선염 치료용 선택적 에스트로겐 수용체 조절제 또는 아로마타아제 저해제 |
| CN101636372B (zh) | 2007-02-14 | 2013-03-27 | 霍尔莫斯医疗有限公司 | 有治疗价值的三苯基丁烯衍生物的制备方法 |
| WO2008099060A2 (en) | 2007-02-14 | 2008-08-21 | Hormos Medical Ltd | Methods for the preparation of fispemifene from ospemifene |
| WO2014060639A1 (en) | 2012-10-19 | 2014-04-24 | Fermion Oy | A process for the preparation of ospemifene |
| CZ305571B6 (cs) * | 2014-01-29 | 2015-12-16 | Smart Brain s.r.o. | Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2 |
| EA029881B1 (ru) * | 2013-04-24 | 2018-05-31 | Смарт Брейн С.Р.О. | Производные тамоксифена для лечения новообразований, особенно с высоким уровнем белка her2 |
| CU20170052A7 (es) | 2014-10-14 | 2017-11-07 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo que se unen a pd-l1 |
| EP3459936B1 (de) * | 2016-06-27 | 2022-04-27 | Daegu-Gyeongbuk Medical Innovation Foundation | Neuartiges arylethanderivat und pharmazeutische zusammensetzung damit als wirkstoff |
| JP2021535923A (ja) * | 2018-09-12 | 2021-12-23 | ザビエル・ユニバーシティ・オブ・ルイジアナXavier University Of Louisiana | エストロゲン受容体を標的にするアンタゴニスト |
| US11850246B2 (en) | 2020-08-04 | 2023-12-26 | Novmetapharma Co., Ltd. | Method for treatment of cytokine release syndrome |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| FI77839C (fi) * | 1982-05-27 | 1989-05-10 | Farmos Oy | Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat. |
| EP0260066B1 (de) * | 1986-09-11 | 1990-05-09 | National Research Development Corporation | Tamoxifenderivate |
-
1991
- 1991-09-27 CA CA002092996A patent/CA2092996A1/en not_active Abandoned
- 1991-09-27 JP JP3518057A patent/JPH06504522A/ja active Pending
- 1991-09-27 EP EP91919917A patent/EP0551434B1/de not_active Expired - Lifetime
- 1991-09-27 AT AT91919917T patent/ATE130293T1/de not_active IP Right Cessation
- 1991-09-27 WO PCT/US1991/007150 patent/WO1992006068A1/en active Search and Examination
- 1991-09-27 AU AU88682/91A patent/AU664161B2/en not_active Ceased
- 1991-09-27 DE DE69114719T patent/DE69114719T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU664161B2 (en) | 1995-11-09 |
| JPH06504522A (ja) | 1994-05-26 |
| EP0551434A1 (de) | 1993-07-21 |
| DE69114719T2 (de) | 1996-10-10 |
| EP0551434B1 (de) | 1995-11-15 |
| WO1992006068A1 (en) | 1992-04-16 |
| DE69114719D1 (de) | 1995-12-21 |
| AU8868291A (en) | 1992-04-28 |
| CA2092996A1 (en) | 1992-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |