DE69114719D1 - Tamoxifenderivate mit hoher affinität und ihre verwendung. - Google Patents

Tamoxifenderivate mit hoher affinität und ihre verwendung.

Info

Publication number
DE69114719D1
DE69114719D1 DE69114719T DE69114719T DE69114719D1 DE 69114719 D1 DE69114719 D1 DE 69114719D1 DE 69114719 T DE69114719 T DE 69114719T DE 69114719 T DE69114719 T DE 69114719T DE 69114719 D1 DE69114719 D1 DE 69114719D1
Authority
DE
Germany
Prior art keywords
tamoxifen
derivatives
tamoxifen derivatives
estrogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69114719T
Other languages
English (en)
Other versions
DE69114719T2 (de
Inventor
David Yang
Sidney Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/589,928 external-priority patent/US5219548A/en
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE69114719D1 publication Critical patent/DE69114719D1/de
Publication of DE69114719T2 publication Critical patent/DE69114719T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
DE69114719T 1990-10-01 1991-09-27 Tamoxifenderivate mit hoher affinität und ihre verwendung. Expired - Fee Related DE69114719T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/589,928 US5219548A (en) 1990-10-01 1990-10-01 High affinity halogenated-tamoxifen derivatives and uses thereof
US07/722,322 US5192525A (en) 1990-10-01 1991-06-28 High affinity tamoxifen derivatives and uses thereof
PCT/US1991/007150 WO1992006068A1 (en) 1990-10-01 1991-09-27 High affinity tamoxifen derivatives and uses thereof

Publications (2)

Publication Number Publication Date
DE69114719D1 true DE69114719D1 (de) 1995-12-21
DE69114719T2 DE69114719T2 (de) 1996-10-10

Family

ID=27080697

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69114719T Expired - Fee Related DE69114719T2 (de) 1990-10-01 1991-09-27 Tamoxifenderivate mit hoher affinität und ihre verwendung.

Country Status (7)

Country Link
EP (1) EP0551434B1 (de)
JP (1) JPH06504522A (de)
AT (1) ATE130293T1 (de)
AU (1) AU664161B2 (de)
CA (1) CA2092996A1 (de)
DE (1) DE69114719T2 (de)
WO (1) WO1992006068A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US6083990A (en) 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
EE200000077A (et) 1997-08-15 2000-12-15 Duke University Östrogeenist sõltuvate haiguste ja häirete vältimise ja ravi meetod
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
JP2006528648A (ja) * 2003-07-24 2006-12-21 ザ クイーンズ メディカル センター アルキル化剤の調製及び使用
KR101505884B1 (ko) 2006-05-22 2015-03-25 호르모스 메디칼 리미티드 만성 비세균성 전립선염 치료용 선택적 에스트로겐 수용체 조절제 또는 아로마타아제 저해제
CN101636372B (zh) 2007-02-14 2013-03-27 霍尔莫斯医疗有限公司 有治疗价值的三苯基丁烯衍生物的制备方法
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
CZ305571B6 (cs) * 2014-01-29 2015-12-16 Smart Brain s.r.o. Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2
EA029881B1 (ru) * 2013-04-24 2018-05-31 Смарт Брейн С.Р.О. Производные тамоксифена для лечения новообразований, особенно с высоким уровнем белка her2
CU20170052A7 (es) 2014-10-14 2017-11-07 Dana Farber Cancer Inst Inc Moléculas de anticuerpo que se unen a pd-l1
EP3459936B1 (de) * 2016-06-27 2022-04-27 Daegu-Gyeongbuk Medical Innovation Foundation Neuartiges arylethanderivat und pharmazeutische zusammensetzung damit als wirkstoff
JP2021535923A (ja) * 2018-09-12 2021-12-23 ザビエル・ユニバーシティ・オブ・ルイジアナXavier University Of Louisiana エストロゲン受容体を標的にするアンタゴニスト
US11850246B2 (en) 2020-08-04 2023-12-26 Novmetapharma Co., Ltd. Method for treatment of cytokine release syndrome

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
FI77839C (fi) * 1982-05-27 1989-05-10 Farmos Oy Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat.
EP0260066B1 (de) * 1986-09-11 1990-05-09 National Research Development Corporation Tamoxifenderivate

Also Published As

Publication number Publication date
AU664161B2 (en) 1995-11-09
ATE130293T1 (de) 1995-12-15
JPH06504522A (ja) 1994-05-26
EP0551434A1 (de) 1993-07-21
DE69114719T2 (de) 1996-10-10
EP0551434B1 (de) 1995-11-15
WO1992006068A1 (en) 1992-04-16
AU8868291A (en) 1992-04-28
CA2092996A1 (en) 1992-04-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee