UA116469C2 - Похідні тамоксифену для лікування новоутворень, особливо з високим рівнем білка her2 - Google Patents
Похідні тамоксифену для лікування новоутворень, особливо з високим рівнем білка her2Info
- Publication number
- UA116469C2 UA116469C2 UAA201510642A UAA201510642A UA116469C2 UA 116469 C2 UA116469 C2 UA 116469C2 UA A201510642 A UAA201510642 A UA A201510642A UA A201510642 A UAA201510642 A UA A201510642A UA 116469 C2 UA116469 C2 UA 116469C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tamoxifen
- treatment
- general formula
- her2 protein
- salts
- Prior art date
Links
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical class C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000001613 neoplastic effect Effects 0.000 title abstract 3
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
- -1 aliphatic triphenylphosphonium derivatives Chemical class 0.000 abstract 5
- 229960001603 tamoxifen Drugs 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5449—Polyphosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/008—Dyes containing a substituent, which contains a silicium atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
Abstract
Метою даного винаходу є нові націлені на мітохондрії E/Z-ізомери аліфатичних трифенілфосфонієвих похідних тамоксифену, де аліфатичний ланцюг являє собою алкіл або алкеніл, та їх відповідні солі третинного аміну та/або їх суміш (MitoTAX). Алкілтрифенілфосфонієві похідні тамоксифену мають загальну формулу І, де n=8-12, і де Z вибраний з групи органічних солей або неорганічних солей. Алкілтрифенілфосфонієві похідні тамоксифену мають загальну формулу ІА, де n=6-10, і де Z має вищезазначене значення. Дані сполуки можна застосувати для лікування новоутворень, особливо новоутворень з високими рівнями білка HER2. Лікарський засіб для лікування новоутворень за даним винаходом містить щонайменше один E/Z-ізомер аліфатичних трифенілфосфонієвих похідних тамоксифену загальної формули І та/або ІА або їх відповідні солі третинного аміну. EMBED MDLDrawOLE.MDLDrawObject.1 , I EMBED MDLDrawOLE.MDLDrawObject.1 IA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ2013-308A CZ2013308A3 (cs) | 2013-04-24 | 2013-04-24 | Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2 |
CZ2014-66A CZ305571B6 (cs) | 2014-01-29 | 2014-01-29 | Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2 |
PCT/CZ2014/000035 WO2014173374A1 (en) | 2013-04-24 | 2014-04-07 | Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level |
Publications (1)
Publication Number | Publication Date |
---|---|
UA116469C2 true UA116469C2 (uk) | 2018-03-26 |
Family
ID=50677895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201510642A UA116469C2 (uk) | 2013-04-24 | 2014-04-07 | Похідні тамоксифену для лікування новоутворень, особливо з високим рівнем білка her2 |
Country Status (22)
Country | Link |
---|---|
US (1) | US9896466B2 (uk) |
EP (1) | EP2989110B1 (uk) |
JP (1) | JP6375091B2 (uk) |
KR (1) | KR101764991B1 (uk) |
CN (1) | CN105452265B (uk) |
AU (1) | AU2014256546B2 (uk) |
CA (1) | CA2909994C (uk) |
CY (1) | CY1120821T1 (uk) |
DK (1) | DK2989110T3 (uk) |
EA (1) | EA029881B1 (uk) |
ES (1) | ES2699099T3 (uk) |
GE (1) | GEP20186868B (uk) |
HK (1) | HK1216317A1 (uk) |
HR (1) | HRP20181872T1 (uk) |
HU (1) | HUE042239T2 (uk) |
MD (1) | MD4626C1 (uk) |
NZ (1) | NZ713589A (uk) |
PL (1) | PL2989110T3 (uk) |
PT (1) | PT2989110T (uk) |
SI (1) | SI2989110T1 (uk) |
UA (1) | UA116469C2 (uk) |
WO (1) | WO2014173374A1 (uk) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10548318B2 (en) * | 2015-07-03 | 2020-02-04 | Bayer Cropscience Aktiengesellschaft | N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide derivatives with herbicidal action |
BR112018000088B1 (pt) * | 2015-07-03 | 2022-07-12 | Bayer Cropscience Aktiengesellschaft | Derivados de n-(1,3,4-oxadiazol-2-il)aril carboxamida com ação herbicida, seu uso, composição herbicida, e método para controle de plantas indesejadas |
CA3030411A1 (en) * | 2016-07-12 | 2018-01-18 | Accutar Biotechnology Inc. | Novel compounds and uses thereof |
US11040019B2 (en) | 2016-08-19 | 2021-06-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration |
EP3330274A1 (en) * | 2016-12-01 | 2018-06-06 | Springtide Ventures s.r.o. | Compounds for treatment of senescence-related disorders |
WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
US11229657B2 (en) | 2017-04-21 | 2022-01-25 | Lunella Biotech, Inc. | Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy |
RU2019142102A (ru) | 2017-05-19 | 2021-06-21 | Лунелла Байотек, Инк. | Антимитосцины: направленные ингибиторы митохондриального биогенеза для эрадикации злокачественных стволовых клеток |
BR112020008022A2 (pt) | 2017-10-24 | 2020-10-27 | Lunella Biotech, Inc. | mitoflavoscinas: o direcionamento de enzimas contendo flavina elimina as células-tronco de câncer (cscs) por meio da inibição da respiração mitocondrial |
JP7066847B2 (ja) | 2017-11-24 | 2022-05-13 | ルネラ・バイオテック・インコーポレーテッド | がん幹細胞を根絶するトリフェニルホスホニウム誘導体化合物 |
US11497759B2 (en) | 2017-12-01 | 2022-11-15 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
WO2019113210A1 (en) | 2017-12-05 | 2019-06-13 | Anthos Partners, Lp | Phosphonium-based ionic drug conjugates |
US11559527B2 (en) | 2017-12-20 | 2023-01-24 | Lunella Biotech, Inc. | Targeting mitochondrial fission through mDIVI-1 derivatives |
KR20210152500A (ko) * | 2019-04-16 | 2021-12-15 | 루넬라 바이오테크 인코포레이티드 | 미토콘드리아 표적화용 알킬-tpp 화합물 및 항암 치료 |
EP3753944A1 (en) | 2019-06-17 | 2020-12-23 | Institute Of Biotechnology Cas, V.V.I. | 3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1289570C (en) * | 1986-06-16 | 1991-09-24 | Tetsuji Asao | 1,1,2-triaryl-1-alkene derivatives |
CA2092996A1 (en) * | 1990-10-01 | 1992-04-02 | David Yang | High affinity tamoxifen derivatives and uses thereof |
JP3635708B2 (ja) * | 1995-03-06 | 2005-04-06 | 出光興産株式会社 | 有機エレクトロルミネッセンス素子 |
TWI309571B (en) * | 2002-12-31 | 2009-05-11 | Ind Tech Res Inst | Delivery carrier for targeting cells haring over-expressed estrogen |
JP4648319B2 (ja) * | 2003-08-22 | 2011-03-09 | アンティポディーン ファーマシューティカルズ インコーポレイティド | ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体 |
SG156613A1 (en) * | 2004-07-13 | 2009-11-26 | Oridis Biomed Forschungs Und E | Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers |
WO2009111846A1 (en) * | 2008-03-14 | 2009-09-17 | Stephen John Ralph | Mitochondrially delivered anti-cancer compounds |
MX2011010956A (es) * | 2009-04-17 | 2012-01-27 | Colby Pharmaceutical Company | Composiciones farmaceuticamente activas que comprenden moduladores de estres oxidativo (osm por sus siglas en inglés), nuevas entidades quimicas, composiciones y usos. |
WO2011129837A1 (en) * | 2010-04-16 | 2011-10-20 | Olema Pharmaceuticals, Inc. | Use of a 4-hydroxytoremifene prodrug for treatment of breast cancer |
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2014
- 2014-04-07 NZ NZ713589A patent/NZ713589A/en unknown
- 2014-04-07 CA CA2909994A patent/CA2909994C/en active Active
- 2014-04-07 MD MD20150117A patent/MD4626C1/ro active IP Right Grant
- 2014-04-07 UA UAA201510642A patent/UA116469C2/uk unknown
- 2014-04-07 SI SI201430928T patent/SI2989110T1/sl unknown
- 2014-04-07 WO PCT/CZ2014/000035 patent/WO2014173374A1/en active Application Filing
- 2014-04-07 AU AU2014256546A patent/AU2014256546B2/en active Active
- 2014-04-07 PL PL14721738T patent/PL2989110T3/pl unknown
- 2014-04-07 US US14/786,710 patent/US9896466B2/en active Active
- 2014-04-07 JP JP2016509298A patent/JP6375091B2/ja active Active
- 2014-04-07 PT PT14721738T patent/PT2989110T/pt unknown
- 2014-04-07 KR KR1020157030376A patent/KR101764991B1/ko active IP Right Grant
- 2014-04-07 DK DK14721738.4T patent/DK2989110T3/en active
- 2014-04-07 ES ES14721738T patent/ES2699099T3/es active Active
- 2014-04-07 HU HUE14721738A patent/HUE042239T2/hu unknown
- 2014-04-07 EP EP14721738.4A patent/EP2989110B1/en active Active
- 2014-04-07 EA EA201591918A patent/EA029881B1/ru unknown
- 2014-04-07 CN CN201480033316.9A patent/CN105452265B/zh active Active
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2015
- 2015-04-07 GE GEAP201513996A patent/GEP20186868B/en unknown
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2016
- 2016-04-14 HK HK16104277.8A patent/HK1216317A1/zh unknown
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2018
- 2018-11-06 CY CY181101155T patent/CY1120821T1/el unknown
- 2018-11-08 HR HRP20181872TT patent/HRP20181872T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014173374A1 (en) | 2014-10-30 |
EA201591918A1 (ru) | 2016-02-29 |
CA2909994A1 (en) | 2014-10-30 |
CN105452265B (zh) | 2017-05-10 |
ES2699099T3 (es) | 2019-02-07 |
CA2909994C (en) | 2018-06-26 |
EA029881B1 (ru) | 2018-05-31 |
MD4626B1 (ro) | 2019-04-30 |
US9896466B2 (en) | 2018-02-20 |
HRP20181872T1 (hr) | 2019-02-08 |
HK1216317A1 (zh) | 2016-11-04 |
JP6375091B2 (ja) | 2018-08-15 |
HUE042239T2 (hu) | 2019-06-28 |
KR20150144756A (ko) | 2015-12-28 |
SI2989110T1 (sl) | 2019-01-31 |
MD4626C1 (ro) | 2019-11-30 |
CY1120821T1 (el) | 2019-12-11 |
AU2014256546B2 (en) | 2017-03-30 |
DK2989110T3 (en) | 2018-12-03 |
CN105452265A (zh) | 2016-03-30 |
NZ713589A (en) | 2017-12-22 |
EP2989110A1 (en) | 2016-03-02 |
JP2016522179A (ja) | 2016-07-28 |
MD20150117A2 (ro) | 2016-08-31 |
AU2014256546A1 (en) | 2015-11-12 |
PT2989110T (pt) | 2018-11-15 |
KR101764991B1 (ko) | 2017-08-10 |
US20160075726A1 (en) | 2016-03-17 |
PL2989110T3 (pl) | 2019-03-29 |
GEP20186868B (en) | 2018-06-25 |
EP2989110B1 (en) | 2018-08-08 |
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