AU2014256546B2 - Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level - Google Patents

Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level Download PDF

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Publication number
AU2014256546B2
AU2014256546B2 AU2014256546A AU2014256546A AU2014256546B2 AU 2014256546 B2 AU2014256546 B2 AU 2014256546B2 AU 2014256546 A AU2014256546 A AU 2014256546A AU 2014256546 A AU2014256546 A AU 2014256546A AU 2014256546 B2 AU2014256546 B2 AU 2014256546B2
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AU
Australia
Prior art keywords
general formula
tamoxifen
triphenylphosphonium
alkyl
drug
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Ceased
Application number
AU2014256546A
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English (en)
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AU2014256546A1 (en
Inventor
Jiri Neuzil
Jan Stursa
Lukas Werner
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BIOTECHNOLOGICKY USTAV AV CR VVI
Smart Brain sro
Springtide Ventures SRO
Original Assignee
BIOTECHNOLOGICKY USTAV AV CR V V I
Smart Brain Sro
Springtide Ventures S R O
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Priority claimed from CZ2013-308A external-priority patent/CZ2013308A3/cs
Priority claimed from CZ2014-66A external-priority patent/CZ305571B6/cs
Application filed by BIOTECHNOLOGICKY USTAV AV CR V V I, Smart Brain Sro, Springtide Ventures S R O filed Critical BIOTECHNOLOGICKY USTAV AV CR V V I
Publication of AU2014256546A1 publication Critical patent/AU2014256546A1/en
Assigned to NEUZIL, JIRI, BIOTECHNOLOGICKY USTAV AV CR, V.V.I., Smart Brain s.r.o., KKCG AG reassignment NEUZIL, JIRI Alteration of Name(s) of Applicant(s) under S113 Assignors: BIOTECHNOLOGICKY USTAV AV CR, V.V.I., KKCG SE, NEUZIL, JIRI, Smart Brain s.r.o.
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Assigned to Smart Brain s.r.o., NEUZIL, JIRI, BIOTECHNOLOGICKY USTAV AV CR, V.V.I., Springtide Ventures S.R.O reassignment Smart Brain s.r.o. Request for Assignment Assignors: KKCG AG, BIOTECHNOLOGICKY USTAV AV CR, V.V.I., NEUZIL, JIRI, Smart Brain s.r.o.
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5449—Polyphosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/001—Dyes containing an onium group attached to the dye skeleton via a bridge
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/008—Dyes containing a substituent, which contains a silicium atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
AU2014256546A 2013-04-24 2014-04-07 Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level Ceased AU2014256546B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CZ2013-308A CZ2013308A3 (cs) 2013-04-24 2013-04-24 Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2
CZPV2013-308 2013-04-24
CZ2014-66A CZ305571B6 (cs) 2014-01-29 2014-01-29 Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2
CZPV2014-66 2014-01-29
PCT/CZ2014/000035 WO2014173374A1 (en) 2013-04-24 2014-04-07 Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level

Publications (2)

Publication Number Publication Date
AU2014256546A1 AU2014256546A1 (en) 2015-11-12
AU2014256546B2 true AU2014256546B2 (en) 2017-03-30

Family

ID=50677895

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014256546A Ceased AU2014256546B2 (en) 2013-04-24 2014-04-07 Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

Country Status (21)

Country Link
US (1) US9896466B2 (https=)
EP (1) EP2989110B1 (https=)
JP (1) JP6375091B2 (https=)
KR (1) KR101764991B1 (https=)
CN (1) CN105452265B (https=)
AU (1) AU2014256546B2 (https=)
CA (1) CA2909994C (https=)
CY (1) CY1120821T1 (https=)
DK (1) DK2989110T3 (https=)
EA (1) EA029881B1 (https=)
ES (1) ES2699099T3 (https=)
GE (2) GEAP201813996A (https=)
HR (1) HRP20181872T1 (https=)
HU (1) HUE042239T2 (https=)
MD (1) MD4626C1 (https=)
NZ (1) NZ713589A (https=)
PL (1) PL2989110T3 (https=)
PT (1) PT2989110T (https=)
SI (1) SI2989110T1 (https=)
UA (1) UA116469C2 (https=)
WO (1) WO2014173374A1 (https=)

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AU2016290425A1 (en) * 2015-07-03 2018-01-18 Bayer Cropscience Aktiengesellschaft N-(tetrazole-5-yl)- and N-(triazole-5-yl)aryl carboxamide derivatives with herbicidal action
US10556874B2 (en) * 2015-07-03 2020-02-11 Bayer Cropscience Aktiengesellschaft N-(1,3,4-oxadiazol-2-yl)aryl carboxamide derivatives with herbicidal action
HK1257296A1 (zh) * 2016-07-12 2019-10-18 Accutar Biotechnology Inc. 新的化合物及其用途
WO2018034945A1 (en) 2016-08-19 2018-02-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration
EP3330274A1 (en) * 2016-12-01 2018-06-06 Springtide Ventures s.r.o. Compounds for treatment of senescence-related disorders
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
CA3060509A1 (en) 2017-04-21 2018-10-25 Federica Sotgia Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
KR20200010343A (ko) 2017-05-19 2020-01-30 루넬라 바이오테크 인코포레이티드 안티미토신: 암 줄기 세포를 근절하기 위한 미토콘드리아 생물발생의 표적화 억제제
RU2020116649A (ru) 2017-10-24 2021-11-30 Лунелла Байотек, Инк. Митофлавосцины: нацеливание на флавин-содержащие ферменты устраняет злокачественные стволовые клетки (cscs) посредством ингибирования митохондриального дыхания
US10980821B2 (en) 2017-11-24 2021-04-20 Lunella Biotech, Inc. Triphenylphosphonium-derivative compounds for eradicating cancer stem cells
US11497759B2 (en) 2017-12-01 2022-11-15 Lunella Biotech, Inc. Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
US11541120B2 (en) 2017-12-05 2023-01-03 Anthos Partners, Lp Phosphonium-based ionic drug conjugates
EP3728300A4 (en) 2017-12-20 2021-08-11 Lunella Biotech, Inc. TARGETING OF MITOCHONDRIAL FISSION BY MDIVI-1 DERIVATIVES
CA3136811A1 (en) * 2019-04-16 2020-10-22 Lunella Biotech, Inc. Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments
EP3753944A1 (en) 2019-06-17 2020-12-23 Institute Of Biotechnology Cas, V.V.I. 3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments

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JPH06504522A (ja) * 1990-10-01 1994-05-26 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 高親和性タモキシフェン誘導体とその使用
JP3635708B2 (ja) * 1995-03-06 2005-04-06 出光興産株式会社 有機エレクトロルミネッセンス素子
TWI309571B (en) * 2002-12-31 2009-05-11 Ind Tech Res Inst Delivery carrier for targeting cells haring over-expressed estrogen
KR101003960B1 (ko) * 2003-08-22 2010-12-30 안티포딘 파마슈티칼스, 인코포레이티드 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물
CN1997403A (zh) * 2004-07-13 2007-07-11 奥里迪斯生物医学研究及开发有限责任公司 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途
NZ602579A (en) * 2008-03-14 2013-12-20 Stephen John Ralph Mitochondrially delivered anti-cancer compounds
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SMITH, R.A.J. et al. "Delivery of bioactive molecules to mitochondria in vivo" Proceedings of the National Academy of Sciences (2003) Vol.100 No.9 pages 5407 to 5412 *

Also Published As

Publication number Publication date
CN105452265A (zh) 2016-03-30
EP2989110B1 (en) 2018-08-08
HUE042239T2 (hu) 2019-06-28
WO2014173374A1 (en) 2014-10-30
CN105452265B (zh) 2017-05-10
MD4626C1 (ro) 2019-11-30
EA201591918A1 (ru) 2016-02-29
JP2016522179A (ja) 2016-07-28
CA2909994A1 (en) 2014-10-30
HK1216317A1 (zh) 2016-11-04
CA2909994C (en) 2018-06-26
EA029881B1 (ru) 2018-05-31
HRP20181872T1 (hr) 2019-02-08
MD4626B1 (ro) 2019-04-30
US20160075726A1 (en) 2016-03-17
AU2014256546A1 (en) 2015-11-12
SI2989110T1 (sl) 2019-01-31
KR101764991B1 (ko) 2017-08-10
PT2989110T (pt) 2018-11-15
KR20150144756A (ko) 2015-12-28
US9896466B2 (en) 2018-02-20
NZ713589A (en) 2017-12-22
MD20150117A2 (ro) 2016-08-31
PL2989110T3 (pl) 2019-03-29
JP6375091B2 (ja) 2018-08-15
UA116469C2 (uk) 2018-03-26
DK2989110T3 (en) 2018-12-03
CY1120821T1 (el) 2019-12-11
EP2989110A1 (en) 2016-03-02
GEAP201813996A (en) 2018-03-12
ES2699099T3 (es) 2019-02-07
GEP20186868B (en) 2018-06-25

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Free format text: FORMER NAME(S): NEUZIL, JIRI; BIOTECHNOLOGICKY USTAV AV CR, V.V.I.; SMART BRAIN S.R.O.; KKCG SE

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