KR101735787B1 - 삼환식 화합물 및 이의 용도 - Google Patents
삼환식 화합물 및 이의 용도 Download PDFInfo
- Publication number
- KR101735787B1 KR101735787B1 KR1020140024555A KR20140024555A KR101735787B1 KR 101735787 B1 KR101735787 B1 KR 101735787B1 KR 1020140024555 A KR1020140024555 A KR 1020140024555A KR 20140024555 A KR20140024555 A KR 20140024555A KR 101735787 B1 KR101735787 B1 KR 101735787B1
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- KR
- South Korea
- Prior art keywords
- methoxy
- methyl
- dihydro
- phenyl
- dibenzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
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- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
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- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
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- Organic Chemistry (AREA)
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130022038 | 2013-02-28 | ||
| KR20130022038 | 2013-02-28 | ||
| KR20130109840 | 2013-09-12 | ||
| KR1020130109840 | 2013-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140108179A KR20140108179A (ko) | 2014-09-05 |
| KR101735787B1 true KR101735787B1 (ko) | 2017-05-16 |
Family
ID=51428545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140024555A Expired - Fee Related KR101735787B1 (ko) | 2013-02-28 | 2014-02-28 | 삼환식 화합물 및 이의 용도 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9643946B2 (https=) |
| EP (1) | EP2963027B1 (https=) |
| JP (1) | JP6387023B2 (https=) |
| KR (1) | KR101735787B1 (https=) |
| CN (2) | CN108017603B (https=) |
| AU (1) | AU2014221489B2 (https=) |
| CA (1) | CA2900348C (https=) |
| ES (1) | ES2709195T3 (https=) |
| WO (1) | WO2014133361A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2013MU03577A (https=) | 2013-11-14 | 2015-07-31 | Cadila Healthcare Ltd | |
| WO2016105383A1 (en) * | 2014-12-23 | 2016-06-30 | Boral Ip Holdings (Australia) Pty Limited | Rapid setting material for improved processing and performance of carbonating metal silicate cement |
| MX2018007844A (es) | 2015-12-22 | 2019-01-21 | Jiangsu Hengrui Medicine Co | Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo. |
| KR102538719B1 (ko) | 2016-12-08 | 2023-06-01 | 메르크 파텐트 게엠베하 | 중합가능한 화합물 및 액정 디스플레이에서 이의 용도 |
| CN108218824B (zh) * | 2016-12-09 | 2020-06-26 | 中国科学院大连化学物理研究所 | 二苯基并[b,d]氧杂环庚烷化合物及其制备和应用 |
| CN110177773B (zh) | 2017-01-26 | 2023-08-25 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途 |
| EP3573959B1 (en) | 2017-01-26 | 2021-07-28 | Boehringer Ingelheim International GmbH | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| JP7050792B2 (ja) | 2017-01-26 | 2022-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
| US10913720B2 (en) | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN111655678B (zh) * | 2018-01-05 | 2023-08-22 | 广州市恒诺康医药科技有限公司 | 细胞凋亡信号调节激酶-1抑制剂及其应用 |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| JP6626524B2 (ja) | 2018-03-29 | 2019-12-25 | 日本碍子株式会社 | 電気加熱型触媒用担体 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN110105193B (zh) * | 2019-05-31 | 2022-03-22 | 杭州科耀医药科技有限公司 | 一种2-卤-5-溴苯甲酸的合成方法 |
| WO2025082467A1 (zh) * | 2023-10-19 | 2025-04-24 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN117510323B (zh) * | 2024-01-08 | 2024-04-05 | 成都泰莱康科技有限公司 | 一种Ramage Linker中间体的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051890A1 (en) * | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3505189B2 (ja) | 1997-02-10 | 2004-03-08 | ファイザー・プロダクツ・インク | 2−アミノ−6−(2−置換−4−フェノキシ)−置換ピリジン |
| WO2001030764A1 (en) | 1999-10-22 | 2001-05-03 | Takeda Chemical Industries, Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
| AU2003277576A1 (en) * | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| CN1735408A (zh) * | 2002-11-08 | 2006-02-15 | 武田药品工业株式会社 | 受体机能调节剂 |
| EP1630152A4 (en) * | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | 3−(4−ベンジルオキシフェニル)プロパン酸誘導体 |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| JP5299810B2 (ja) * | 2004-02-27 | 2013-09-25 | アムジエン・インコーポレーテツド | 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法 |
| JP5084503B2 (ja) * | 2005-07-29 | 2012-11-28 | 武田薬品工業株式会社 | シクロプロパンカルボン酸化合物 |
| CA2646430A1 (en) * | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| BRPI0713378A8 (pt) * | 2006-06-27 | 2018-01-02 | Takeda Pharmaceutical | composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto |
| CA2662305C (en) | 2006-09-07 | 2012-04-17 | Amgen Inc. | Heterocyclic gpr40 modulators |
| EP2139843B1 (en) * | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| PE20090595A1 (es) | 2007-08-15 | 2009-06-06 | Glaxo Group Ltd | Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1 |
| CA2703217A1 (en) * | 2007-10-29 | 2009-05-07 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| EP2423176A4 (en) * | 2009-04-22 | 2012-11-07 | Astellas Pharma Inc | CARBOXYLIC ACID COMPOUND |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
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- 2014-02-28 WO PCT/KR2014/001686 patent/WO2014133361A1/ko not_active Ceased
- 2014-02-28 AU AU2014221489A patent/AU2014221489B2/en not_active Ceased
- 2014-02-28 KR KR1020140024555A patent/KR101735787B1/ko not_active Expired - Fee Related
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| WO2005051890A1 (en) * | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
Also Published As
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| CN105209448B (zh) | 2018-09-14 |
| EP2963027A1 (en) | 2016-01-06 |
| EP2963027B1 (en) | 2018-12-26 |
| JP6387023B2 (ja) | 2018-09-05 |
| CN108017603A (zh) | 2018-05-11 |
| CN105209448A (zh) | 2015-12-30 |
| CN108017603B (zh) | 2021-07-23 |
| EP2963027A4 (en) | 2016-07-20 |
| KR20140108179A (ko) | 2014-09-05 |
| AU2014221489A1 (en) | 2015-10-08 |
| AU2014221489B2 (en) | 2018-03-08 |
| JP2016513135A (ja) | 2016-05-12 |
| ES2709195T3 (es) | 2019-04-15 |
| US20160009677A1 (en) | 2016-01-14 |
| US9643946B2 (en) | 2017-05-09 |
| CA2900348A1 (en) | 2014-09-04 |
| WO2014133361A1 (ko) | 2014-09-04 |
| CA2900348C (en) | 2021-06-22 |
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