JP6387023B2 - 三環式化合物およびその使用 - Google Patents

三環式化合物およびその使用 Download PDF

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Publication number
JP6387023B2
JP6387023B2 JP2015560105A JP2015560105A JP6387023B2 JP 6387023 B2 JP6387023 B2 JP 6387023B2 JP 2015560105 A JP2015560105 A JP 2015560105A JP 2015560105 A JP2015560105 A JP 2015560105A JP 6387023 B2 JP6387023 B2 JP 6387023B2
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Japan
Prior art keywords
methoxy
methyl
dihydro
phenyl
dibenzo
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Expired - Fee Related
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JP2015560105A
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Japanese (ja)
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JP2016513135A (ja
JP2016513135A5 (https=
Inventor
ヨン イ、チュ
ヨン イ、チュ
ア イ、チョン
ア イ、チョン
アン、チェスン
ホ リュ、チェ
ホ リュ、チェ
ハン、ミン−ヨン
ユ、テキョン
ホ サ、チュン
ホ サ、チュン
キム、チェ−ソン
ソ、チョンミン
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Tiumbio Co Ltd
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Tiumbio Co Ltd
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
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    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
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    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
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JP2015560105A 2013-02-28 2014-02-28 三環式化合物およびその使用 Expired - Fee Related JP6387023B2 (ja)

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KR10-2013-0022038 2013-02-28
KR20130022038 2013-02-28
KR20130109840 2013-09-12
KR10-2013-0109840 2013-09-12
PCT/KR2014/001686 WO2014133361A1 (ko) 2013-02-28 2014-02-28 삼환식 화합물 및 이의 용도

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JP2016513135A JP2016513135A (ja) 2016-05-12
JP2016513135A5 JP2016513135A5 (https=) 2017-02-16
JP6387023B2 true JP6387023B2 (ja) 2018-09-05

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US (1) US9643946B2 (https=)
EP (1) EP2963027B1 (https=)
JP (1) JP6387023B2 (https=)
KR (1) KR101735787B1 (https=)
CN (2) CN108017603B (https=)
AU (1) AU2014221489B2 (https=)
CA (1) CA2900348C (https=)
ES (1) ES2709195T3 (https=)
WO (1) WO2014133361A1 (https=)

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IN2013MU03577A (https=) 2013-11-14 2015-07-31 Cadila Healthcare Ltd
WO2016105383A1 (en) * 2014-12-23 2016-06-30 Boral Ip Holdings (Australia) Pty Limited Rapid setting material for improved processing and performance of carbonating metal silicate cement
MX2018007844A (es) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.
KR102538719B1 (ko) 2016-12-08 2023-06-01 메르크 파텐트 게엠베하 중합가능한 화합물 및 액정 디스플레이에서 이의 용도
CN108218824B (zh) * 2016-12-09 2020-06-26 中国科学院大连化学物理研究所 二苯基并[b，d]氧杂环庚烷化合物及其制备和应用
CN110177773B (zh) 2017-01-26 2023-08-25 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途
EP3573959B1 (en) 2017-01-26 2021-07-28 Boehringer Ingelheim International GmbH Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
JP7050792B2 (ja) 2017-01-26 2022-04-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用
US10913720B2 (en) 2017-01-26 2021-02-09 Boehringer Ingelheim International Gmbh Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
US10550127B1 (en) 2017-02-08 2020-02-04 Boehringer Ingelheim International Gmbh Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CN111655678B (zh) * 2018-01-05 2023-08-22 广州市恒诺康医药科技有限公司 细胞凋亡信号调节激酶-1抑制剂及其应用
TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
JP6626524B2 (ja) 2018-03-29 2019-12-25 日本碍子株式会社 電気加熱型触媒用担体
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP3820572B1 (en) 2018-07-13 2023-08-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN110105193B (zh) * 2019-05-31 2022-03-22 杭州科耀医药科技有限公司 一种2-卤-5-溴苯甲酸的合成方法
WO2025082467A1 (zh) * 2023-10-19 2025-04-24 成都先导药物开发股份有限公司 一种免疫调节剂
CN117510323B (zh) * 2024-01-08 2024-04-05 成都泰莱康科技有限公司 一种Ramage Linker中间体的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3505189B2 (ja) 1997-02-10 2004-03-08 ファイザー・プロダクツ・インク ２−アミノ−６−（２−置換−４−フェノキシ）−置換ピリジン
WO2001030764A1 (en) 1999-10-22 2001-05-03 Takeda Chemical Industries, Ltd. 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
AU2003277576A1 (en) * 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
CN1735408A (zh) * 2002-11-08 2006-02-15 武田药品工业株式会社 受体机能调节剂
EP1630152A4 (en) * 2003-05-30 2009-09-23 Takeda Pharmaceutical CONDENSED CYCLIC COMPOUND
WO2005051890A1 (en) * 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
JP4074616B2 (ja) * 2003-12-25 2008-04-09 武田薬品工業株式会社 ３−（４−ベンジルオキシフェニル）プロパン酸誘導体
AU2004309271A1 (en) 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
JP5299810B2 (ja) * 2004-02-27 2013-09-25 アムジエン・インコーポレーテツド 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法
JP5084503B2 (ja) * 2005-07-29 2012-11-28 武田薬品工業株式会社 シクロプロパンカルボン酸化合物
CA2646430A1 (en) * 2006-03-14 2007-09-20 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
BRPI0713378A8 (pt) * 2006-06-27 2018-01-02 Takeda Pharmaceutical composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto
CA2662305C (en) 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
EP2139843B1 (en) * 2007-04-16 2013-12-25 Amgen, Inc Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
PE20090595A1 (es) 2007-08-15 2009-06-06 Glaxo Group Ltd Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1
CA2703217A1 (en) * 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2423176A4 (en) * 2009-04-22 2012-11-07 Astellas Pharma Inc CARBOXYLIC ACID COMPOUND
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament

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US20160009677A1 (en) 2016-01-14
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