AU2014221489B2 - Tricyclic compound and use thereof - Google Patents

Tricyclic compound and use thereof Download PDF

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Publication number
AU2014221489B2
AU2014221489B2 AU2014221489A AU2014221489A AU2014221489B2 AU 2014221489 B2 AU2014221489 B2 AU 2014221489B2 AU 2014221489 A AU2014221489 A AU 2014221489A AU 2014221489 A AU2014221489 A AU 2014221489A AU 2014221489 B2 AU2014221489 B2 AU 2014221489B2
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Prior art keywords
methoxy
methyl
phenyl
dihydro
dibenzo
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AU2014221489A
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AU2014221489A1 (en
Inventor
Jaeseung AHN
Min-Young Han
Jae-Sun Kim
Jeong A. Lee
Ju Young Lee
Je Ho Ryu
Joon Ho Sa
Jeongmin Seo
Taekyung YOO
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Tiumbio Co Ltd
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Tiumbio Co Ltd
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Assigned to TIUMBIO CO., LTD. reassignment TIUMBIO CO., LTD. Request for Assignment Assignors: SK CHEMICALS CO., LTD.
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Publication of AU2014221489B2 publication Critical patent/AU2014221489B2/en
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    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C59/40Unsaturated compounds
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AU2014221489A 2013-02-28 2014-02-28 Tricyclic compound and use thereof Ceased AU2014221489B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2013-0022038 2013-02-28
KR20130022038 2013-02-28
KR20130109840 2013-09-12
KR10-2013-0109840 2013-09-12
PCT/KR2014/001686 WO2014133361A1 (ko) 2013-02-28 2014-02-28 삼환식 화합물 및 이의 용도

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AU2014221489A1 AU2014221489A1 (en) 2015-10-08
AU2014221489B2 true AU2014221489B2 (en) 2018-03-08

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AU2014221489A Ceased AU2014221489B2 (en) 2013-02-28 2014-02-28 Tricyclic compound and use thereof

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US (1) US9643946B2 (https=)
EP (1) EP2963027B1 (https=)
JP (1) JP6387023B2 (https=)
KR (1) KR101735787B1 (https=)
CN (2) CN108017603B (https=)
AU (1) AU2014221489B2 (https=)
CA (1) CA2900348C (https=)
ES (1) ES2709195T3 (https=)
WO (1) WO2014133361A1 (https=)

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IN2013MU03577A (https=) 2013-11-14 2015-07-31 Cadila Healthcare Ltd
WO2016105383A1 (en) * 2014-12-23 2016-06-30 Boral Ip Holdings (Australia) Pty Limited Rapid setting material for improved processing and performance of carbonating metal silicate cement
MX2018007844A (es) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo.
KR102538719B1 (ko) 2016-12-08 2023-06-01 메르크 파텐트 게엠베하 중합가능한 화합물 및 액정 디스플레이에서 이의 용도
CN108218824B (zh) * 2016-12-09 2020-06-26 中国科学院大连化学物理研究所 二苯基并[b,d]氧杂环庚烷化合物及其制备和应用
CN110177773B (zh) 2017-01-26 2023-08-25 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途
EP3573959B1 (en) 2017-01-26 2021-07-28 Boehringer Ingelheim International GmbH Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
JP7050792B2 (ja) 2017-01-26 2022-04-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用
US10913720B2 (en) 2017-01-26 2021-02-09 Boehringer Ingelheim International Gmbh Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
US10550127B1 (en) 2017-02-08 2020-02-04 Boehringer Ingelheim International Gmbh Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CN111655678B (zh) * 2018-01-05 2023-08-22 广州市恒诺康医药科技有限公司 细胞凋亡信号调节激酶-1抑制剂及其应用
TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
JP6626524B2 (ja) 2018-03-29 2019-12-25 日本碍子株式会社 電気加熱型触媒用担体
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP3820572B1 (en) 2018-07-13 2023-08-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN110105193B (zh) * 2019-05-31 2022-03-22 杭州科耀医药科技有限公司 一种2-卤-5-溴苯甲酸的合成方法
WO2025082467A1 (zh) * 2023-10-19 2025-04-24 成都先导药物开发股份有限公司 一种免疫调节剂
CN117510323B (zh) * 2024-01-08 2024-04-05 成都泰莱康科技有限公司 一种Ramage Linker中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1559422A1 (en) * 2002-11-08 2005-08-03 Takeda Pharmaceutical Company Limited Receptor function controlling agent
WO2005086661A2 (en) * 2004-02-27 2005-09-22 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3505189B2 (ja) 1997-02-10 2004-03-08 ファイザー・プロダクツ・インク 2−アミノ−6−(2−置換−4−フェノキシ)−置換ピリジン
WO2001030764A1 (en) 1999-10-22 2001-05-03 Takeda Chemical Industries, Ltd. 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
CN1735408A (zh) * 2002-11-08 2006-02-15 武田药品工业株式会社 受体机能调节剂
EP1630152A4 (en) * 2003-05-30 2009-09-23 Takeda Pharmaceutical CONDENSED CYCLIC COMPOUND
WO2005051890A1 (en) * 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
JP4074616B2 (ja) * 2003-12-25 2008-04-09 武田薬品工業株式会社 3−(4−ベンジルオキシフェニル)プロパン酸誘導体
AU2004309271A1 (en) 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
JP5084503B2 (ja) * 2005-07-29 2012-11-28 武田薬品工業株式会社 シクロプロパンカルボン酸化合物
CA2646430A1 (en) * 2006-03-14 2007-09-20 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
BRPI0713378A8 (pt) * 2006-06-27 2018-01-02 Takeda Pharmaceutical composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto
CA2662305C (en) 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
EP2139843B1 (en) * 2007-04-16 2013-12-25 Amgen, Inc Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
PE20090595A1 (es) 2007-08-15 2009-06-06 Glaxo Group Ltd Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1
CA2703217A1 (en) * 2007-10-29 2009-05-07 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2423176A4 (en) * 2009-04-22 2012-11-07 Astellas Pharma Inc CARBOXYLIC ACID COMPOUND
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1559422A1 (en) * 2002-11-08 2005-08-03 Takeda Pharmaceutical Company Limited Receptor function controlling agent
WO2005086661A2 (en) * 2004-02-27 2005-09-22 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

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CN105209448A (zh) 2015-12-30
CN108017603B (zh) 2021-07-23
EP2963027A4 (en) 2016-07-20
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AU2014221489A1 (en) 2015-10-08
JP2016513135A (ja) 2016-05-12
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US20160009677A1 (en) 2016-01-14
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