KR101727776B1 - 플라비비리다에 바이러스의 억제제 - Google Patents

플라비비리다에 바이러스의 억제제 Download PDF

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KR101727776B1
KR101727776B1 KR1020127021314A KR20127021314A KR101727776B1 KR 101727776 B1 KR101727776 B1 KR 101727776B1 KR 1020127021314 A KR1020127021314 A KR 1020127021314A KR 20127021314 A KR20127021314 A KR 20127021314A KR 101727776 B1 KR101727776 B1 KR 101727776B1
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KR20120101733A (ko
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에다 카날레스
마이클 오닐 한라한 클라크
스코트 이. 라저위드
윌라드 류
필립 앤쏘니 모르가넬리
윌리엄 제이. 왓킨스
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길리애드 사이언시즈, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020127021314A 2010-01-15 2011-01-14 플라비비리다에 바이러스의 억제제 Active KR101727776B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29557610P 2010-01-15 2010-01-15
US61/295,576 2010-01-15
US35348110P 2010-06-10 2010-06-10
US61/353,481 2010-06-10
PCT/US2011/021335 WO2011088345A1 (en) 2010-01-15 2011-01-14 Inhibitors of flaviviridae viruses

Publications (2)

Publication Number Publication Date
KR20120101733A KR20120101733A (ko) 2012-09-14
KR101727776B1 true KR101727776B1 (ko) 2017-04-17

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KR1020127021314A Active KR101727776B1 (ko) 2010-01-15 2011-01-14 플라비비리다에 바이러스의 억제제

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Country Link
US (2) US8513298B2 (https=)
EP (2) EP3219713A1 (https=)
JP (2) JP5868872B2 (https=)
KR (1) KR101727776B1 (https=)
CN (1) CN102712633B (https=)
AP (1) AP3576A (https=)
AR (1) AR080001A1 (https=)
AU (1) AU2011205744B2 (https=)
BR (1) BR112012017382A2 (https=)
CA (1) CA2785567C (https=)
CL (1) CL2012001960A1 (https=)
CR (1) CR20120417A (https=)
EA (1) EA021196B1 (https=)
EC (1) ECSP12012104A (https=)
ES (1) ES2626150T3 (https=)
IL (1) IL220545B (https=)
MX (1) MX2012008211A (https=)
NZ (1) NZ600817A (https=)
PE (1) PE20130281A1 (https=)
PL (1) PL2523950T3 (https=)
PT (1) PT2523950T (https=)
SG (2) SG182475A1 (https=)
SI (1) SI2523950T1 (https=)
TW (1) TWI491609B (https=)
UY (1) UY33183A (https=)
WO (1) WO2011088345A1 (https=)
ZA (1) ZA201205248B (https=)

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AP3576A (en) 2010-01-15 2016-02-08 Gilead Sciences Inc Inhibitors of flaviviridae viruses
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Also Published As

Publication number Publication date
US8513298B2 (en) 2013-08-20
IL220545B (en) 2018-02-28
MX2012008211A (es) 2012-08-08
ES2626150T3 (es) 2017-07-24
ECSP12012104A (es) 2012-09-28
AR080001A1 (es) 2012-03-07
KR20120101733A (ko) 2012-09-14
CN102712633A (zh) 2012-10-03
AU2011205744B2 (en) 2015-06-25
JP5868872B2 (ja) 2016-02-24
CA2785567A1 (en) 2011-07-21
SG10201500298PA (en) 2015-03-30
JP2013517291A (ja) 2013-05-16
BR112012017382A2 (pt) 2017-12-05
US20110178129A1 (en) 2011-07-21
US20130315861A1 (en) 2013-11-28
US9321753B2 (en) 2016-04-26
AP3576A (en) 2016-02-08
SI2523950T1 (sl) 2017-06-30
NZ600817A (en) 2014-08-29
CN102712633B (zh) 2015-07-29
EP3219713A1 (en) 2017-09-20
EP2523950B1 (en) 2017-03-15
TWI491609B (zh) 2015-07-11
AP2012006414A0 (en) 2012-08-31
PE20130281A1 (es) 2013-03-08
CA2785567C (en) 2018-03-27
PL2523950T3 (pl) 2017-09-29
PT2523950T (pt) 2017-06-01
EA021196B1 (ru) 2015-04-30
IL220545A0 (en) 2012-08-30
EP2523950A1 (en) 2012-11-21
UY33183A (es) 2011-08-31
ZA201205248B (en) 2013-03-27
EA201290576A1 (ru) 2013-01-30
CL2012001960A1 (es) 2012-10-26
SG182475A1 (en) 2012-08-30
WO2011088345A1 (en) 2011-07-21
AU2011205744A1 (en) 2012-07-26
TW201134822A (en) 2011-10-16
CR20120417A (es) 2012-11-30
JP2016041732A (ja) 2016-03-31

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