KR101723827B1 - 신규한 에로모나스 살모니시다 박테리오파지 Aer-SAP-1 및 이의 에로모나스 살모니시다 균 증식 억제 용도 - Google Patents

신규한 에로모나스 살모니시다 박테리오파지 Aer-SAP-1 및 이의 에로모나스 살모니시다 균 증식 억제 용도 Download PDF

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KR101723827B1
KR101723827B1 KR1020150149869A KR20150149869A KR101723827B1 KR 101723827 B1 KR101723827 B1 KR 101723827B1 KR 1020150149869 A KR1020150149869 A KR 1020150149869A KR 20150149869 A KR20150149869 A KR 20150149869A KR 101723827 B1 KR101723827 B1 KR 101723827B1
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bacteriophage
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윤성준
전수연
권안성
송현민
엄태희
강상현
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Abstract

본 발명은 에로모나스 살모니시다 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 미오비리대 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP), 및 이를 유효성분으로 포함하는 조성물을 이용한 에로모나스 살모니시다 균의 감염을 방지 및 처치하는 방법에 관한 것이다.

Description

신규한 에로모나스 살모니시다 박테리오파지 Aer-SAP-1 및 이의 에로모나스 살모니시다 균 증식 억제 용도{Novel Aeromonas salmonicida bacteriophage Aer-SAP-1 and its use for preventing proliferation of Aeromonas salmonicida}
본 발명은 에로모나스 살모니시다 균에 감염하여 에로모나스 살모니시다 균을 사멸시킬 수 있는 자연으로부터 분리한 박테리오파지 및 이를 유효성분으로 포함한 조성물을 이용한 에로모나스 살모니시다 균의 감염을 방지 및 처치하는 방법에 관한 것으로, 더욱 상세하게는 에로모나스 살모니시다 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 미오비리대 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP), 및 상기 박테리오파지를 유효성분으로 포함하는 조성물을 이용한 에로모나스 살모니시다 균의 감염 방지 및 감염 후 처치 방법에 관한 것이다.
에로모나스 과(Aeromonadaceae)에 속하는 에로모나스 살모니시다(Aeromonas salmonicida)는 그람 음성균이고, 통성혐기성이며 비운동성인 단간균으로서 다양한 어종에서 광범위하게 세균성 패혈증(Septicemia)이나 절창병(Furunculosis)을 일으키는 세균으로 알려져 있다. 특히, 이름에서 연상되듯이 과거에는 연어 및 무지개 송어 등의 연어과(Salmonid) 어류에서 절창병과 같은 치사율이 높은 질병을 유발하는 병원성 박테리아로 보고되었으나, 최근에 와서는 잉어과 어류 등에서도 자주 검출되고 있는 추세이다. 또한, 에로모나스 살모니시다 균은 인돌(Indole) 생성 반응에 대해서는 음성 반응을 보이나, 카탈라아제(Catalase) 및 옥시다아제(Oxidase) 시험에서는 양성 반응을 보이는 특징을 가진다. 이 세균의 적합 생장 온도는 22∼25℃이나, 최고 34.5℃에서도 생장이 가능하다.
에로모나스 감염증은 세계최대 연어 양식국인 노르웨이를 포함한 유럽뿐만 아니라 북아메리카, 호주 등 전 세계적으로 발병 사례가 보고되고 있으며, 국내에서는 2010년에 경상남도 산청 지방의 양식장에서 우리나라 최초로 에로모나스 살모니시다의 쏘가리 감염 사례가 보고된 바 있다. 에로모나스 살모니시다 균에 감염된 어류의 일반적인 특징으로는 지느러미에 염증이 일어나고 지느러미가 너덜너덜해지기도 하나, 때때로 경미하거나 심각한 혼탁 현상만이 지느러미에 나타나는 경우도 있다. 또한, 2∼20 mm 길이의 화농성 종기 및 병변이 형성되기도 하고 2차 감염으로 곰팡이의 이상 증식이 발견되기도 한다. 내부적인 이상 증상으로는 표피, 아가미, 지느러미, 및 근육 조직에서 미량의 출혈, 체표 팽윤, 및 내부절창장염 등이 흔히 관찰된다.
에로모나스 살모니시다 균 감염에 의한 에로모나스 감염증은 치어에서 성어까지 개체의 크기에 상관없이 발병하고 이에 따라 초래하는 경제적 피해가 매우 크기 때문에 에로모나스 살모니시다 균 감염을 예방하고 나아가 감염 처치에까지 활용될 수 있는 방안의 개발이 절실한 실정이다. 특히, 최근 수산물의 식품으로서의 안전성이 주요 사회적 관심사가 되고 있기 때문에 친환경적인 방안이면 더욱 바람직하다.
어류 양식 산업은 부족한 식량자원을 손쉽게 얻을 수 있다는 점에서 해마다 급속한 성장을 거듭하고 있다. 그러나 이러한 양식 산업의 성장이 증가 할수록 사료를 통한 주변 환경의 오염 역시 증가하고 있고 특히 사료에 포함되어 있는 많은 양의 항생제가 광범위하게 사용됨으로써 오히려 인류의 건강을 위협하기도 한다. 무지개 송어를 비롯한 어류 양식장에서는 세균성 질병의 치료 방법으로서 과다하게 항균 화학요법제인 항생제가 사용되고 있고, 이러한 결과로 다양한 약제에 대한 내성을 지닌 균이 빈번하게 나타나고 있어서, 어류 양식 어가에 상당한 경제적 손실을 입히고 있는 실정이다. 또한, 이러한 항생제의 과다한 사용은 국민 건강을 위협하고 나아가서는 양식 어류의 소비 심리를 위축시켜서 전반적인 수산업의 경쟁력 저하를 야기할 수 있다. 따라서 세균에 의한 어류 질병을 방지할 수 있고 또한 이들의 감염을 효과적으로 처치할 수 있는 방법의 개발이 절실하다 할 수 있다.
최근에는 양식 어류의 질병제어를 위한 수단으로 백신(Vaccine) 개발 등이 본격화 되고 있으나 아직 백신종류가 다양화되지 못해 질병종류가 다양화 되고 혼합질병 발생 증가에 따른 대처를 위해서는 백신과 함께 또 다른 질병제어 수단이 추가적으로 개발되어야 한다.
최근 세균성 질환의 대처 방안으로 박테리오파지(Bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 자연친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 박테리오파지는 세균에 감염하는 아주 작은 미생물로서 보통 파지(Phage)라고 줄여서 부르기도 한다. 박테리오파지는 박테리아에 감염(Infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 이러한 박테리오파지의 세균 특이성은 목적으로 하는 세균에 대해서만 항균효과를 제공하고 환경이나 어류 내의 상재균들에는 영향을 초래하지 않는다. 통상적으로 기존의 항생제들은 여러 종류의 세균들에 대하여 동시에 영향을 끼쳤다. 박테리오파지는 특정 세균에 대해서만 작동하므로 박테리오파지 사용에 의해서 체내 정상균총 교란 등이 발생하지 않는다. 따라서 그 사용이 항생제 사용에 비교하여 매우 안전하고 그 만큼 부작용 초래 가능성이 상대적으로 크게 낮다.
박테리오파지는 1915년 영국의 세균학자 Twort가 포도상구균(Micrococcus) 집락이 어떤 것에 의해 투명하게 녹는 현상에 대한 연구를 수행하면서 발견되었다. 또한, 1917년에는 프랑스의 세균학자 d'Herelle이 이질환자 변의 여과액 중에 적리균(Shigella dysenteriae)을 녹이는 작용을 가진 것이 있다는 것을 발견하고 이에 대한 연구를 통해 독립적으로 박테리오파지를 발견하였으며, 세균을 잡아먹는다는 뜻에서 박테리오파지라고 명명하였다. 이후 이질균, 장티푸스균, 콜레라균 등 여러 병원성 박테리아에 대한 박테리오파지가 계속적으로 발견되었다.
박테리아를 사멸시킬 수 있는 특별한 능력으로 인하여 박테리오파지는 발견 이후 박테리아 감염에 대응하는 효과적 방안으로 기대를 모았으며 관련하여 많은 연구들이 있었다. 그러나 Fleming에 의해 페니실린이 발견된 이후, 항생제의 보급이 일반화되면서 박테리오파지에 대한 연구는 일부 동유럽 국가들 및 구소련에 한정되어서만 명맥이 유지되었다. 그런데 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
특히 최근 항생제 사용에 대한 정부 차원의 규제가 전 세계적으로 강화됨에 따라 박테리오파지에 대한 관심이 더욱 높아지고 있으며 산업적 활용 사례도 증가하고 있다.
앞에서 설명했듯이 박테리오파지는 세균에 대한 특이성이 매우 높다. 이러한 특이성으로 인하여 박테리오파지는 동일 종류에 속하는 세균들이라 할지라도 그 일부 주(Strain)에 대해서만 항균효과를 발휘하는 경우가 많다. 또한 대상 세균주에 따라 발휘되는 박테리오파지의 항균력 세기 자체도 다를 수 있다. 이러한 이유로 특정 종류의 세균에 대하여 효과적 제어법을 확보하려면 다양한 종류의 유용 박테리오파지의 확보가 필요하다. 에로모나스 살모니시다 균에 대응하여 효과적인 박테리오파지 활용법을 개발하기 위해서도 당연히 다양한 유용 박테리오파지들(에로모나스 살모니시다 균에 대하여 항균효과를 제공할 수 있는 여러 종류의 박테리오파지들)의 확보가 필요하고, 더 나아가 확보한 다양한 유용 박테리오파지들 중에서 항균력의 세기나 항균범위 측면에서 비교우위에 있는 박테리오파지의 선발도 필요하다.
이에, 본 발명자들은 에로모나스 살모니시다 균을 선택적으로 사멸시킬 수 있는 자연으로부터 분리된 박테리오파지를 이용하여 에로모나스 살모니시다 균의 감염을 방지 또는 처치하는 데에 활용될 수 있는 조성물을 개발하고, 또 이 조성물을 이용하여 에로모나스 살모니시다 균의 감염을 방지 또는 처치하는 방법을 개발하고자 노력한 끝에, 이에 적합한 박테리오파지를 자연으로부터 분리하고 이 분리된 박테리오파지를 타 박테리오파지와 구별하여 특정 지을 수 있도록 유전체(Genome)의 유전자 서열을 확보한 후 상기 박테리오파지를 유효성분으로 한 조성물을 개발한 다음 이 조성물이 에로모나스 살모니시다 균의 감염 방지 및 처치에 효과적으로 활용될 수 있음을 확인함으로써 본 발명을 완성하였다.
따라서 본 발명의 목적은 에로모나스 살모니시다 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 미오비리대(Myoviridae) 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP)을 제공하는 것이다.
본 발명의 또 다른 목적은 에로모나스 살모니시다 균에 감염하여 에로모나스 살모니시다 균을 사멸시킬 수 있는 분리 박테리오파지 Aer-SAP-1을 유효성분으로 포함하는 에로모나스 살모니시다 균의 감염을 방지하는 데에 활용 가능한 조성물 및 이 조성물을 이용한 에로모나스 살모니시다 균의 감염 방지 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 에로모나스 살모니시다 균에 감염하여 에로모나스 살모니시다 균을 사멸시킬 수 있는 분리 박테리오파지 Aer-SAP-1을 유효성분으로 포함하는 에로모나스 살모니시다 균의 감염을 처치하는 데에 활용 가능한 조성물 및 이 조성물을 이용한 에로모나스 살모니시다 균의 감염 처치 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 조성물들을 이용한 에로모나스 살모니시다 균 감염 방지 및 처치 목적의 약욕제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 조성물들을 이용한 에로모나스 살모니시다 균 감염 방지 및 처치를 통한 사양 효과 제공 목적의 사료첨가제를 제공하는 것이다.
본 발명은 에로모나스 살모니시다 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 미오비리대 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP), 및 이를 유효성분으로 포함하는 조성물을 이용한 에로모나스 살모니시다 균의 감염 방지 및 처치 방법을 제공한다.
박테리오파지 Aer-SAP-1은 본 발명자들에 의해 분리된 후 2015년 5월 20일자로 한국생명공학연구원 미생물자원센터에 기탁되었다(수탁번호 KCTC 12814BP).
또한, 본 발명은 에로모나스 살모니시다 균의 감염을 방지 또는 처치하는 데에 활용될 수 있는 박테리오파지 Aer-SAP-1을 유효성분으로 포함하는 약욕제 및 사료첨가제를 제공한다.
본 발명의 조성물에 포함되는 박테리오파지 Aer-SAP-1은 에로모나스 살모니시다 균을 효과적으로 사멸시키므로 에로모나스 살모니시다 균에 의해 유발되는 질병의 예방(감염 방지)이나 치료(감염 처치)에 효과를 나타낸다. 따라서 본 발명의 조성물은 에로모나스 살모니시다 균에 의해 유발되는 대표적인 질병인 절창병 및 세균성 패혈증에 대한 예방 및 치료 목적으로 활용될 수 있으나, 이에 한정되는 것은 아니다.
본 명세서에서 사용된 “처치” 또는 “치료”라는 용어는 (ⅰ) 에로모나스 살모니시다 균에 의해 유발된 질환의 억제; 및 (ⅱ) 에로모나스 살모니시다 균에 의해 유발된 질환의 병적 상태를 경감시키는 모든 행위를 의미한다.
본 명세서의 “분리” 또는 “분리된”은 자연 상태로부터 여러 실험 기법을 활용하여 박테리오파지를 분리하는 것과 타 박테리오파지와 구별하여 특정 지을 수 있는 특징들을 확보하는 일을 지칭하며, 이에 더하여 생물공학기술로 박테리오파지를 산업적으로 활용할 수 있게끔 증식시키는 것도 포함한다.
본 발명의 조성물에 포함되는 약제학적으로 허용되는 담체는 제제 시에 통상적으로 이용되는 것으로서, 락토오스, 덱스트로오스, 수크로오스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산칼슘, 알지네이트, 젤라틴, 규산칼슘, 미세결정성 셀룰로오스, 폴리비닐피롤리돈, 셀룰로오스, 물, 시럽, 메틸 셀룰로오스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘 및 미네랄 오일 등을 포함하나, 이에 한정되는 것은 아니다. 본 발명의 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다.
본 발명의 조성물에는 박테리오파지 Aer-SAP-1이 유효성분으로 포함된다. 이때 포함되는 박테리오파지 Aer-SAP-1은 1× 101 pfu/㎖ 내지 1× 1030 pfu/㎖ 또는 1× 101 pfu/g 내지 1× 1030 pfu/g로 포함되며, 바람직하게는 1× 104 pfu/㎖ 내지 1× 1015 pfu/㎖ 또는 1× 104 pfu/g 내지 1× 1015 pfu/g로 포함된다.
본 발명의 조성물은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 약학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화 됨으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수도 있다. 이때 제형은 오일 또는 수성 매질 중의 용액, 현탁액 또는 유화액 형태이거나 엑스제, 분말제, 과립제, 정제 또는 캡슐제 형태일 수도 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수도 있다.
본 발명의 조성물은 활용 방식에 따라, 이에 국한되지 않지만, 약욕제 및 사료첨가제로 구현될 수 있다.
이러한 활용 목적에서의 효율성을 높이기 위하여 다른 세균종에 대하여 항균활성을 제공할 수 있는 박테리오파지들이 본 발명의 조성물에 추가될 수 있다. 또한, 에로모나스 살모니시다 균에 대하여 항균활성을 갖는 다른 종류의 박테리오파지들도 추가될 수 있다. 비록 에로모나스 살모니시다 균에 대하여 항균활성을 갖는 박테리오파지라 하더라도 항균력의 세기나 항균범위 측면에서 차이가 있으므로 이들의 적절한 조합은 그 효과를 극대화 할 수 있다.
본 발명의 박테리오파지 Aer-SAP-1을 유효성분으로 포함하는 조성물을 이용한 에로모나스 살모니시다 균의 감염 방지 및 처치 방법은 기존의 항생제 등의 화학물질에 기반을 둔 방식에 비하여 에로모나스 살모니시다 균에 대한 특이성이 매우 높다는 장점을 제공할 수 있다. 이는 다른 유용한 상재균에는 영향을 주지 않으면서도 에로모나스 살모니시다 균의 감염 방지 또는 처치 목적으로 사용할 수 있음을 의미하며, 이의 사용에 따른 부작용이 매우 적다. 통상적으로 항생제 등의 화학물질을 사용하면 일반 상재균들도 피해를 함께 입게 되어 결과적으로 동물의 면역력 저하 등을 초래하여 다양한 부작용이 나타난다. 한편, 본 발명은 자연계에 이미 존재하는 박테리오파지를 분리하여 조성물의 유효성분으로 사용하기 때문에 매우 자연 친화적이라는 장점 또한 제공할 수 있다. 한편, 박테리오파지는 항균활성을 발휘할 수 있는 세균종이 같다 하더라도 항균효과 발휘에 있어 항균력의 세기나 항균범위[에로모나스 살모니시다 균에 속하는 여러 세균 주(Strain)의 측면에서 개별 세균 주에 대하여 박테리오파지의 항균활성이 발휘되는 범위. 통상적으로 박테리오파지는 같은 세균 종(Species)에 속하는 일부 세균 주(Strain)에 대하여 항균활성을 발휘할 수 있음. 즉, 같은 세균 종에 속한다 하더라도 개별 세균 주에 따라 박테리오파지에 대한 감수성에서 차이가 있을 수 있음] 측면에서 차이가 있으므로 본 발명은 에로모나스 살모니시다 균에 대한 항균력을 갖는 타 박테리오파지에 비교하여 차별적 항균효과를 제공할 수 있다. 이는 산업현장 활용 시에 그 효과에 있어 큰 차이를 제공한다.
도 1은 박테리오파지 Aer-SAP-1의 전자현미경 사진이다.
도 2는 박테리오파지 Aer-SAP-1의 에로모나스 살모니시다 균에 대한 사멸능을 보여주는 실험 결과이다. 투명한 부분은 시험대상 박테리아가 용균되어 결과적으로 형성된 용균반이다.
이하, 실시예에 의거하여 본 발명을 보다 구체적으로 설명하지만, 이들 실시예는 본 발명의 예시일 뿐이며 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.
실시예 1: 에로모나스 살모니시다 균을 사멸시킬 수 있는 박테리오파지의 분리
에로모나스 살모니시다 균을 사멸시킬 수 있는 박테리오파지의 선별에는 자연 환경으로부터 확보된 시료들을 이용하였다. 한편, 박테리오파지 분리에 사용된 에로모나스 살모니시다 균은 본 발명자들에 의해 미리 분리되어 에로모나스 살모니시다 균으로 동정(Identification)된 것이다.
박테리오파지 분리 과정을 상세히 설명하면, 수집된 시료를 에로모나스 살모니시다 균을 1/1,000 비율로 접종한 TSB(Tryptic Soy Broth) 배지(카제인 다이제스트, 17 g/L; 소이빈 다이제스트, 3 g/L; 덱스트로스, 2.5 g/L; NaCl, 5 g/L; 디포타슘 포스페이트, 2.5 g/L)에 함께 첨가한 다음 25℃에서 3-4시간동안 진탕배양 하였다. 배양 후, 8,000 rpm에서 20분간 원심분리하여 상등액을 회수하였다. 회수된 상등액에 에로모나스 살모니시다 균을 1/1,000 비율로 접종한 다음 25℃에서 3-4시간동안 또 다시 진탕배양 하였다. 박테리오파지가 시료에 포함되어 있었을 경우 박테리오파지의 수(Titer)가 증가될 수 있도록 이러한 과정을 총 5회 반복하였다. 5회 반복 후에 배양액을 8,000 rpm에서 20분간 원심분리 하였다. 원심분리 후, 회수된 상등액을 0.45 ㎛의 필터를 이용하여 여과를 실시해 주었다. 얻어진 여과액을 사용한 통상의 점적 실험(Spot assay)을 통하여 에로모나스 살모니시다 균을 사멸시킬 수 있는 박테리오파지가 있는지를 조사하였다.
상기 점적 실험은 다음과 같이 실시되었다. TSB 배지에 에로모나스 살모니시다 균을 1/1,000 비율로 접종한 다음 25℃에서 한밤동안 진탕배양 하였다. 이렇게 하여 준비된 에로모나스 살모니시다 균의 배양액 3 ㎖(OD600이 1.5)을 TSA(Tryptic Soy Agar) 평판배지(카제인 다이제스트, 15 g/L; 소이빈 다이제스트, 5 g/L; NaCl, 5 g/L; 아가, 15 g/L)에 도말(Spreading)하였다. 도말한 평판 배지를 클린벤치(Clean bench)에서 약 30분 정도 방치하여 도말액이 건조되게 하였다. 건조 후 앞에서 준비한 여과액 10 μl를 에로모나스 살모니시다 균이 도말된 평판 배지 위에 점적하였다. 이를 30분 정도 방치하여 건조시켰다. 건조 후 점적한 평판 배지를 25℃에서 하루 동안 정치 배양한 다음 여과액이 떨어진 위치에 투명환(Clear zone)이 생성되는가를 조사하였다. 투명환이 생성되는 여과액의 경우가 에로모나스 살모니시다 균을 사멸 시킬 수 있는 박테리오파지가 포함되어 있다고 판단할 수 있다. 이러한 조사를 통하여 에로모나스 살모니시다 균에 대한 사멸능을 가진 박테리오파지를 포함한 여과액을 확보할 수 있었다.
에로모나스 살모니시다 균에 대한 사멸능을 가진 박테리오파지의 존재가 확인된 여과액을 이용하여 순수 박테리오파지의 분리를 실시하였다. 순수 박테리오파지의 분리에는 통상의 용균반 분석(Plaque assay)을 이용하였다. 이를 자세히 설명하면, 용균반 분석에서 형성된 용균반 하나를 멸균된 팁을 이용하여 회수한 다음 이를 에로모나스 살모니시다 균 배양액에 첨가해 주어 4-5 시간 동안 25℃에서 함께 배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액에 50분의 1의 부피로 에로모나스 살모니시다 균 배양액을 첨가해 준 다음 다시 25℃에서 4-5 시간 배양해 주었다. 박테리오파지의 수를 증가시키기 위하여 이러한 과정을 최소 5회 이상 실시한 다음 최종적으로 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액을 사용하여 다시 용균반 분석을 실시하였다. 통상 순수 박테리오파지의 분리가 상기 과정의 1회로 달성되지 않기 때문에 이때 형성된 용균반을 이용하여 앞 단계를 전체적으로 다시 반복하였다. 이와 같은 과정을 최소 5회 이상 실시하여 순수한 박테리오파지를 포함한 용액을 확보하였다. 통상적으로 순수 박테리오파지의 분리는 형성된 용균반의 크기 및 모양이 모두 유사하게 될 때까지 반복하였다. 그리고 최종적으로는 전자현미경을 통하여 박테리오파지의 순수 분리 여부를 확인하였다. 전자현미경 분석에서 순수 분리가 확인될 때까지 앞에 기술한 과정을 반복하였다. 전자현미경 분석은 통상의 방법에 따라 실시하였다. 이를 간단히 설명하면 다음과 같다. 순수한 박테리오파지를 포함한 용액을 구리 격자(Copper grid)에 묻히고 2% 우라닐 아세테이트(Uranyl acetate)로 역염색법(Negative staining)과 건조를 수행한 후 투과전자현미경을 통하여 그 형태를 촬영하였다. 순수 분리한 박테리오파지의 전자현미경 사진이 도 1에 제시되어 있다. 형태적 특징으로 판단할 때 신규 확보된 박테리오파지는 미오비리대(Myoviridae) 박테리오파지에 속함을 확인할 수 있었다.
이런 방식으로 확인된 순수 박테리오파지를 포함한 용액은 다음의 정제 과정을 거쳤다. 순수 박테리오파지를 포함한 용액 전체 부피의 50분의 1의 부피로 에로모나스 살모니시다 균 배양액을 첨가해 준 다음 다시 4-5 시간 배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 충분한 수의 박테리오파지가 포함된 액을 얻기 위해 이러한 과정을 총 5회 반복하였다. 최종 원심분리로 얻어진 상등액을 0.45 μm의 필터를 이용하여 여과한 다음 통상의 폴리에틸렌 글리콜(Polyethylene Glycol; PEG) 침전 과정을 실시하였다. 구체적으로, 여과액 100 ㎖에 10% PEG 8000/0.5 M NaCl이 되게 PEG와 NaCl을 첨가한 다음 4℃에서 2-3시간 동안 정치한 후, 8,000 rpm에서 30분간 원심분리하여 박테리오파지 침전물을 얻었다. 이렇게 얻어진 박테리오파지 침전물을 완충액(Buffer; 10 mM Tris-HCl, 10 mM MgSO4, 0.1% Gelatin, pH 8.0) 5 ㎖로 부유시켰다. 이를 박테리오파지 부유액 또는 박테리오파지 액이라 지칭한다.
이렇게 하여 정제된 순수 박테리오파지를 확보할 수 있었고, 이 박테리오파지를 박테리오파지 Aer-SAP-1로 명명한 뒤, 2015년 5월 20일자로 한국생명공학연구원 미생물자원센터(수탁번호 KCTC 12814BP)에 기탁하였다.
실시예 2: 박테리오파지 Aer -SAP-1의 유전체 분리 및 서열 분석
박테리오파지 Aer-SAP-1의 유전체를 다음과 같이 분리하였다. 유전체 분리에는 실시예 1에서와 같은 방법으로 얻어진 박테리오파지 부유액을 이용하였다. 먼저 부유액에 포함되어 있을 수 있는 에로모나스 살모니시다 균의 DNA와 RNA를 제거하기 위해, 박테리오파지 부유액 10 ㎖에 DNase I과 RNase A를 각각 200 U씩 첨가한 다음 37℃에서 30분간 방치하였다. 30분 방치 후에 DNase I과 RNase A의 활성을 제거하기 위해, 0.5 M 에틸렌디아민테트라아세트산(Ethylenediaminetetraacetic acid; EDTA) 500 μl를 첨가한 다음 다시 10분간 정치시켰다. 그리고 이를 추가로 10분간 65℃에 정치시킨 다음 박테리오파지 외벽을 와해시키기 위해 proteinase K(20 ㎎/㎖) 100 μl를 첨가한 후 37℃에서 20분간 반응시켰다. 그 후 10% 도데실 황산 나트륨염(Sodium dodecyl sulfate; SDS) 500 μl를 첨가한 다음 다시 65℃에서 1시간 동안 반응시켰다. 1 시간 반응 후, 이 반응액에 25:24:1의 구성비를 갖는 페놀(Phenol) : 클로로포름(Chloroform) : 이소아밀알코올(Isoamylalcohol)의 혼합액 10 ㎖을 첨가해 준 후 잘 섞어 주었다. 그리고는 이것을 13,000 rpm에서 15분간 원심분리하여 층이 분리되게 한 다음 분리된 층들 중에서 위층을 취하여 여기에 1.5 부피비의 이소프로필 알코올(Isopropyl alcohol)을 첨가한 다음 13,000 rpm에서 10분간 원심분리하여 유전체를 침전시켰다. 침전물을 회수한 후 침전물에 70% 에탄올(Ethanol)을 첨가한 다음 다시 13,000 rpm에서 10분간 원심분리하여 침전물의 세척을 실시하였다. 세척된 침전물을 회수하고 진공 건조 시킨 다음 100 μl의 물에 녹였다. 상기 과정을 반복하여 박테리오파지 Aer-SAP-1의 유전체를 다량 확보하였다.
이렇게 얻어진 유전체는 ㈜천랩에서 Roche 454 GS Junior 기기의 차세대 염기서열 분석(Next generation sequencing analysis)을 통하여 박테리오파지 Aer-SAP-1의 유전체 서열분석을 실시하였다. 최종적으로 분석된 박테리오파지 Aer-SAP-1 유전체는 162,883 bp의 크기를 가지며, 전체 유전체 서열은 서열번호 1로 제시되어 있다.
확보된 박테리오파지 Aer-SAP-1의 유전체 서열을 기반으로 Web상의 BLAST(http://www.ncbi.nlm.nih.gov/BLAST/)를 이용하여 기존에 알려진 박테리오파지 유전체 서열과의 상동성(Similarity)을 조사해 보았다. BLAST 조사 결과, 박테리오파지 Aer-SAP-1의 유전체 서열은 에로모나스 박테리오파지 phiAS4의 서열(Genbank Accession No. HM452125.1), 스테노트로포모나스(Stenotrophomonas) 박테리오파지 IME13의 서열(Genbank Accession No. JX306041.1), 에로모나스 박테리오파지 Aes508의 서열(Genbank Accession No. JN377894.1), 에로모나스 박테리오파지 Aes012의 서열(Genbank Accession No. JN377895.1), 및 에로모나스 살모니시다 박테리오파지 25의 서열(Genbank Accession No. DQ529280.1)과 비교적 높은 상동성을 가지고 있는 것으로 확인되었다(Query coverage/identity: 각각 순서대로 96%/97%, 94%/96%, 89%/97%, 93%/97%, 및 93%/98%). 그러나 박테리오파지 Aer-SAP-1은 환형의 유전체를 가짐에 반하여 에로모나스 박테리오파지 phiAS4, 에로모나스 박테리오파지 Aes508, 에로모나스 박테리오파지 Aes012, 및 에로모나스 살모니시다 박테리오파지 25는 선형의 유전체를 가져 유전체 형태에서 큰 차이가 있었으며, 박테리오파지 Aer-SAP-1 유전체 상의 개방형해독틀(Open Reading Frame, ORF)의 개수가 234개임에 반하여 스테노트로포모나스 박테리오파지 IME13은 182개를 가지고 있어 서로 상이한 박테리오파지임을 확인할 수 있었다.
이러한 사실에 근거하여 박테리오파지 Aer-SAP-1은 기존에 보고된 바 없는 신규한 박테리오파지라고 판단할 수 있었다. 이러한 사실과 함께 통상적으로 박테리오파지의 종류가 다르면 제공할 수 있는 항균력의 세기 및 항균범위가 다르다는 사실로부터 박테리오파지 Aer-SAP-1은 기존에 보고된 다른 박테리오파지들과는 다른 항균효과를 제공해 줄 수 있다고 판단하였다.
실시예 3: 박테리오파지 Aer -SAP-1의 에로모나스 살모니시다 균에 대한 사멸능 조사
분리된 박테리오파지 Aer-SAP-1의 에로모나스 살모니시다 균에 대한 사멸능을 조사하였다. 사멸능 조사에는 실시예 1에서와 같은 방법으로 점적 실험을 통하여 투명환 생성 여부를 조사하였다. 사멸능 조사에 사용되어진 에로모나스 살모니시다 균은 본 발명자들에 의해 분리되어 에로모나스 살모니시다 균으로 동정된 것들로 총 13주이었다. 박테리오파지 Aer-SAP-1은 실험에 대상이 된 에로모나스 살모니시다 균 중 11주에 대하여 사멸능을 갖고 있었다. 대표적 실험 결과가 도 2에 제시되어 있다. 한편, 박테리오파지 Aer-SAP-1의 에드워드시엘라 타르다(Edwardsiella tarda), 비브리오 안길라룸(Vibrio anguillarum), 비브리오 익티오엔테리(Vibrio ichthyoenteri), 락토코커스 가르비에(Lactococcus garvieae), 및 스트렙토코커스 파라우베리스(Streptococcus parauberis)에 대한 사멸능 조사도 별도 실험으로 실시하였는데, 그 결과로 박테리오파지 Aer-SAP-1은 이들 균종들에 대해서는 사멸능을 갖고 있지 않았다.
이상의 결과로 박테리오파지 Aer-SAP-1은 에로모나스 살모니시다 균에 대하여 특이적인 사멸능을 가지며, 다수의 에로모나스 살모니시다 균에 대하여 항균 효과를 발휘할 수 있음을 확인할 수 있었다. 이는 박테리오파지 Aer-SAP-1이 에로모나스 살모니시다 균의 감염 방지 및 처치 목적의 조성물의 유효성분으로 활용 가능함을 의미한다.
실시예 4: 박테리오파지 Aer -SAP-1의 에로모나스 살모니시다 균의 감염 예방에 대한 실험예
9 ㎖의 TSB 배지를 담은 하나의 튜브에 1× 108 pfu/㎖ 수준의 박테리오파지 Aer-SAP-1 액 100 μl를 넣어주고, 다른 하나의 9 ㎖의 TSB 배지를 담은 튜브에는 동량의 TSB 배지만을 추가로 첨가하였다. 그 다음에 각 튜브에 600 nm에서 흡광도가 약 0.5 정도가 되도록 에로모나스 살모니시다 균의 배양액을 넣어 주었다. 에로모나스 살모니시다 균을 첨가한 후 튜브들을 25℃의 배양기에 옮겨 진탕배양하면서 에로모나스 살모니시다 균의 성장 상태를 관찰하였다. 표 1에 제시된 바와 같이, 박테리오파지 Aer-SAP-1 액을 첨가해 준 튜브에서는 에로모나스 살모니시다 균의 성장 억제가 관찰된 반면에 박테리오파지 액을 첨가하지 않은 튜브에서는 에로모나스 살모니시다 균의 성장 억제가 관찰되지 않았다.
에로모나스 살모니시다 균의 성장 억제
구분 OD600 흡광도 값
배양 0분 배양후 60분 배양후 120분
박테리오파지 액 미첨가 0.502 0.863 1.465
박테리오파지 액 첨가 0.502 0.254 0.132
이 결과로부터 본 발명의 박테리오파지 Aer-SAP-1이 에로모나스 살모니시다 균의 성장을 저해할 뿐만 아니라 사멸까지 시키는 능력이 있음을 확인할 수 있었고, 이로부터 박테리오파지 Aer-SAP-1이 에로모나스 살모니시다 균의 감염을 방지하는 목적의 조성물 유효성분으로 활용될 수 있다고 결론지을 수 있었다.
실시예 5: 박테리오파지 Aer -SAP-1을 이용한 에로모나스 살모니시다 균의 감염 예방 동물실험
무지개 송어를 이용하여 박테리오파지 Aer-SAP-1의 에로모나스 살모니시다 균 감염 예방 효과를 조사하였다. 생후 5주령의 무지개 송어(평균 체장: 15.9 cm, 평균 체중: 24.0 g) 20마리를 한 그룹으로 하여 총 두 그룹으로 나눈 후 수조에서 분리 사육하면서 14일간 실험을 실시하였다. 수조의 주위환경은 통제하였고, 수조가 있는 실험실의 온도는 일정하게 유지시켰다. 실험 개시일부터 실험군(박테리오파지 투여군)의 무지개 송어들에게는 1× 108 pfu/g의 박테리오파지 Aer-SAP-1을 포함하고 있는 사료를 통상적인 사료 급이 방식에 따라 급이하였다. 반면에 대조군(박테리오파지 미투여군)의 무지개 송어들에게는 박테리오파지 Aer-SAP-1이 포함되지 않은 동일 조성의 사료를 동일한 방식으로 급이하였다. 시험개시일로부터 7일째가 되는 날부터 실험군과 대조군 모두 2일간 1× 108 cfu/g 수준으로 에로모나스 살모니시다 균을 급이하는 사료에 포함시켜 하루 2회씩 급이하여 에로모나스 살모니시다 균 감염을 유도하였다. 2일간의 에로모나스 살모니시다 균을 포함하고 있는 사료 급이 시행 다음날(시험 개시일로부터 9일째가 되는 날)부터 매일 모든 시험동물들을 대상으로 절창병 발생 상태를 조사하였다. 절창병 발생 상태 조사는 체표의 궤양 크기를 측정하는 방식으로 실시하였다. 체표의 궤양 크기 측정은 통상 사용되는 Ulcer size(US) score{정상(궤양 없음): 0, 약한 궤양(궤양 크기: 0.5 cm 미만): 1, 강한 궤양(궤양 크기: 0.5 cm 이상): 2}를 측정하는 방식으로 실시하였다.
시험 결과, 2일간의 에로모나스 살모니시다 균을 포함하고 있는 사료 급이 다음 날부터 절창병의 임상증상을 보이는 개체가 대조군 수조에서 확인되었다. 그 결과는 표 2와 같았다.
체표 궤양 크기 측정 결과 (평균치)
날짜 D9 D10 D11 D12 D13 D14
대조군(박테리오파지 미투여) 0.45 0.5 0.65 0.7 0.7 0.7
실험군(박테리오파지 투여) 0 0 0 0 0 0
이 결과로부터 본 발명의 박테리오파지 Aer-SAP-1이 에로모나스 살모니시다 균을 원인으로 하는 감염 질환의 예방에 매우 효과적이라는 것을 확인할 수 있었다.
실시예 6: 박테리오파지 Aer -SAP-1을 이용한 에로모나스 살모니시다 균의 감염 질환 처치예
에로모나스 살모니시다 균에 의해 절창병이 유발된 무지개 송어에서의 박테리오파지 Aer-SAP-1의 처치 효과를 조사하였다. 생후 5주령의 무지개 송어(평균 체장: 15.8 cm, 평균 체중: 23.9 g) 40마리를 한 그룹으로 하여 총 두 그룹으로 나눈 후 수조에서 분리 사육하면서 14일간 실험을 실시하였다. 수조의 주위환경은 통제하였고, 수조가 있는 실험실의 온도는 일정하게 유지시켰다. 실험 개시일로부터 5일째 되는 날부터 3일간 1× 108 cfu/g 수준으로 에로모나스 살모니시다 균을 포함하고 있는 사료를 하루 2회씩 통상적인 사료 급이 방식으로 급이하였다. 에로모나스 살모니시다 균을 포함하고 있는 사료 급이 마지막 날부터 절창병의 임상증상을 보이는 개체가 두 수조 모두에서 확인되었다. 3일간의 에로모나스 살모니시다 균을 포함하고 있는 사료 급이 시행 다음날(시험 개시일로부터 8일째가 되는 날)부터 실험군(박테리오파지 투여군)의 무지개 송어들에게는 1× 108 pfu/g의 박테리오파지 Aer-SAP-1을 포함하고 있는 사료를 통상적인 사료 급이 방식에 따라 급이하였다. 반면에 대조군(박테리오파지 미투여군)의 무지개 송어들에게는 박테리오파지 Aer-SAP-1이 포함되지 않은 동일 조성의 사료를 동일한 방식으로 급이하였다. 시험 개시일로부터 8일째가 되는 날부터는 매일 모든 시험동물들을 대상으로 절창병 발생 상태를 조사하였다. 절창병 발생 상태 조사는 체표의 궤양 크기를 측정하는 방식으로 실시하였다. 체표의 궤양 크기 측정은 통상 사용되는 Ulcer size(US) score{정상(궤양 없음): 0, 약한 궤양(궤양 크기: 0.5 cm 미만): 1, 강한 궤양(궤양 크기: 0.5 cm 이상): 2}를 측정하는 방식으로 실시하였다.
그 결과는 표 3과 같았다.
체표 궤양 크기 측정 결과 (평균치)
날짜 D8 D9 D10 D11 D12 D13 D14
대조군(박테리오파지 미투여) 1.00 1.40 1.60 1.70 1.65 1.65 1.70
실험군(박테리오파지 투여) 1.05 0.95 0.55 0.45 0.35 0.15 0.15
이 결과로부터 본 발명의 박테리오파지 Aer-SAP-1이 에로모나스 살모니시다 균을 원인으로 하는 감염 질환의 처치에도 매우 효과적이라는 것을 확인할 수 있었다.
실시예 7: 사료첨가제 및 사료의 제조
박테리오파지 Aer-SAP-1 액을 이용하여 사료첨가제 1 g당 1× 108 pfu의 박테리오파지 Aer-SAP-1이 포함되도록 사료첨가제를 제조하였다. 사료첨가제의 제조 방법은 박테리오파지 액에 말토덱스트린을 첨가(50%, w/v)한 다음에 동결건조시켜 제조하였다. 최종적으로 고운 가루 형태로 분쇄하였다. 상기 제조 과정 중의 건조 과정에는 감압 건조, 가온 건조, 상온 건조도 대체 가능하다. 대조 실험을 위해, 박테리오파지가 포함되지 않은 사료첨가제도 박테리오파지 액 대신에 박테리오파지 액의 제조 시에 사용한 완충액(Buffer; 10 mM Tris-HCl, 10 mM MgSO4, 0.1% Gelatin, pH 8.0)을 사용하는 방식으로 제조하였다.
이렇게 제조된 2종의 사료첨가제 각각을 중량비로 250배의 양어용 생사료와 혼합하여 최종 2종의 사료를 제조하였다.
실시예 8: 약욕제의 제조
박테리오파지 Aer-SAP-1 액을 이용하여 약욕제 1 ㎖당 1× 108 pfu의 박테리오파지 Aer-SAP-1이 포함되도록 약욕제를 제조하였다. 약욕제의 제조 방법은 박테리오파지 액 제조 시에 사용하는 완충액 1 ㎖당 1× 108 pfu의 박테리오파지 Aer-SAP-1이 포함되도록 상기 박테리오파지 Aer-SAP-1 액을 첨가하여 잘 혼합해 주는 방식으로 제조하였다. 대조 실험을 위해, 박테리오파지가 포함되지 않은 약욕제로는 박테리오파지 액의 제조 시에 사용한 완충액 자체를 그대로 사용하였다.
이렇게 제조된 2종의 약욕제는 부피비로 1,000배의 물로 희석하여 최종적인 약욕제로 사용하였다.
실시예 9: 무지개 송어 사육에서의 사양 효과 확인
실시예 7 및 실시예 8에서 제조한 사료와 약욕제를 이용하여 무지개 송어 사육 시의 사양 결과 개선 여부에 대하여 조사해 보았다. 특히 본 조사는 폐사율 관점에서 실시되었다. 총 100 마리의 무지개 송어를 50 마리씩 한 그룹으로 총 2개 그룹(사료로 급이한 그룹-A; 약욕제로 처치한 그룹-B)으로 나누어 4주간 시험을 실시하였다. 각 그룹은 다시 25마리로 구성되는 소그룹으로 나누어지며 각 소그룹은 박테리오파지 Aer-SAP-1이 적용된 소그룹(소그룹-①) 및 박테리오파지가 적용되지 않은 소그룹(소그룹-②)으로 나누었다. 본 시험에 대상이 된 무지개 송어는 5주령의 무지개 송어 치어였으며, 각 시험 소그룹의 무지개 송어는 일정 간격을 두고 위치한 격리된 각각의 수조에서 사육되었다. 각 소그룹은 다음의 표 4와 같이 구분되고 지칭되었다.
무지개 송어 사양 시험에서의 소그룹 구분 및 표시
적용 소그룹 구분 및 표시
박테리오파지
Aer-SAP-1 적용		 박테리오파지가
적용되지 않음
사료로 급이한 그룹 A-① A-②
약욕제로 처치한 그룹 B-① B-②
사료 급이의 경우에는 실시예 7에서 설명한 사료 제조 방식에 따라 제조한 사료를 표 4의 구분에 따라 통상적인 사료 급이 방식을 따라 급이 하였으며, 약욕제 처치의 경우에는 실시예 8에서 설명한 약욕제 제조 방식에 따라 제조한 약욕제를 표 4의 구분에 따라 통상적인 약욕제 처치 방식에 따라 처치하였다. 시험 결과가 표 5에 제시되어 있다.
무지개 송어 사양 시험에서의 폐사율
그룹 폐사개체수/시험개체수 폐사율(%)
A-① 1/25 4.0
A-② 7/25 28.0
B-① 2/25 8.0
B-② 8/25 32.0
이상의 결과로 본 발명에 따라 제조된 사료의 급이와 본 발명에 따른 약욕제 처치가 무지개 송어 사육에서의 폐사율 감소에 효과가 있음을 확인할 수 있었다. 이로부터 본 발명의 조성물의 적용이 무지개 송어의 사양 결과 개선에 효과적이라는 결론을 내릴 수 있었다.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.
KCTC KCTC12814BP 20150520
SEQUENCE LISTING <110> iNtRON Biotechnology, Co. Ltd. <120> Novel Aeromonas salmonicida bacteriophage Aer-SAP-1 and its use for preventing proliferation of Aeromonas salmonicida <130> KP090420 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 162883 <212> DNA <213> Bacteriophage Aer-SAP-1 <400> 1 attgctcgtt gaaatccgga attcttcgca atttcgtcgt acgcacggca gattaaatca 60 gaataagcat cgctttgccg ccgcatcggt ttacctttcc agtacagagt ttgatctctc 120 caccagtttt tctttttgcc tttaaatttg gcggctttac caaccagagt gcaaacgtgt 180 tcttgcattt caggcgattt gaatttgaga gactgaagga atccttccat tgaggaacat 240 ttaatcccat cgataacgaa ttcatgcgga gcaaaattac tcaatgcaca cgatggccaa 300 ggcgcgccgg atccgatatc catagtattt tcctcaaatt ggtgggttct gctagtatcg 360 aaatagcatc atcaggatgc aaagcaacct acggtcttcc cattaaacga agaacccaaa 420 ttggtgaccc tggtaggaat cgaacctact acgagcggtt atgagccgcc tgcttgaacc 480 gtctagctac agggccgtca gatgaaaaag ccgataacga tcattcgatt ggtcgccggc 540 gttgttattc gggcgcttgt tagggtctcg aacccatcac aaatatacgt atgtgtgaac 600 tgccagacaa caagtactta gaaagctact ttaaggttcc ggttcgcgac cctttcccat 660 attttgctat tttcccacgt tcaacaagcg attgaagttg gaagcgatga gcggattcga 720 accgctgatt ttcgggatat gagcccgacg aggacgacct ctcctctaca tcgcatcaaa 780 atttagagcg gagccaccga ggatcgaact cggtgctgtc ccgtgacagg ggactatttt 840 aaccaaataa actatggctc cgctctaaac tctgttttgg tatgagttaa taatatcact 900 cattgagaaa tttgaaacaa tatgcttcag gatacatttg gcggagaagg agagatttga 960 actctcgaaa cctttcggtt tacttcctta gcagggaagc gatttcagcc gctcatccac 1020 ttctcctaaa aatttggtag tggatattgg gatcgaacca atgcgctctc gattatcggt 1080 cgagtgctct acctactgag ctaatccact attggcatga catcaaggat tcgaaccctg 1140 gccgcacggt tttggagacc ggcatgctac cgctaacacc aatgtcatat tgaaacgatc 1200 tgggcgcacc atttccagac aaaacctcgt cggaggccaa gggccagcaa gatatgatac 1260 aggccgacgc cctcgtcata tcaagatggt cttccctttt acttaacgaa cgggtccgaa 1320 gaaatccgtt cctttaaatt tggtgccgat tgtccgactc gaacggacca ccccagcgtt 1380 acaaaggctg tgctctacca gatgagctaa accggcaatt aatcatgtat atttacgcca 1440 tctccgttag atgaagcaaa tacaagatta gatgaacttt tcaatcgaat gctatcaatt 1500 ggagtatgga aatcaaatct gcttaaaatg tgaaccaaat caccaacggt caggtcacgc 1560 gaaattttgt ttgtgtcaac ttcaatttca cgccaagtct taacgacgga ggtaatacag 1620 ctgctatcga tttcccattc tttttgacaa accgcacatt tagcaatcca accatcacca 1680 gcatcacatg ggccatagca gaattcatgt gaaccaatga attggttttg atcacaacag 1740 acatcgcgcg tggttgtaat tttgacaaca ttcataatat gttcctcaga gttagttcaa 1800 ttcttcaaac actcttccct aacgctgcag ctcgggacat cgagatttca gtttttaacg 1860 tggggatgtc tcgaccgcca cataaacaag agtgtttgaa gaattggagt cagggcctta 1920 cggatgtgac tcaattcttc agtttgcgcc gttctggata accgcatcac tgggatagtg 1980 ccaggagagg atgttaccac attcgacgac tttacggact tgtttgcaac caagtatccg 2040 cttacgtaat ttggtctcag cggggtgaat cgaacacccg aaaattccgt cccaaacgga 2100 acgacatacc acttgcctac gctgagattg aattcgttac cccgtctata cttcctcgtt 2160 tcaccgcgca aaatgacggg agtgactact gaagttttgt ccgaggattt tacgggacgt 2220 ctcccgattt ctcttgttaa agccggtcat ctaagtgccg gagacaatac ggttgtccaa 2280 ctcgcgggct ccagtcacgg cgcaataatg gacagtgcat caaccagggg tgcgaaactg 2340 actaggaatc tagagccctg tgacttgtgt ttggagcggg tagccggtat cgaaccggtc 2400 tactcaagct tggaaggcta gcatgtatcc ataaacacct tacccgcgaa aataatcatt 2460 ggggtgacct acggggttcg aacccgtact ccctgggtca catccaggat agctaccatt 2520 actactaagg tcacaccaat gattacttga aactaatttg cagtgaatga tacaggactc 2580 gaacctgtcc tccggcgcct aaaaggtggt gtgcttggcc gtacactcgt cattcaaatt 2640 gtagcaccct ggaatcttcg taatcatacg tcgaacgtta ctcggtatgg tcgtaagatg 2700 acagttcatt acaacttctt tactgcgaaa tctggtgcgc cgcgatggat tcgaaccatc 2760 gaccctccgg ttaaaagccg gatgctctac cagctaagct agcgacgcgt tgatgttctg 2820 tacaacatca tttaaagtgg tggaacgcct tggactcgaa ccaagaatgc cagaggcgag 2880 cgggttacag ccgcttggga taccattacc cgaacgttcc taaattgtcc atcaaagatt 2940 tcaagtcttt ctctcttttt aacttaaaca aatcgattac agcttttttc gacgatctac 3000 cgttgacata ctcgatttgt atccactcgt ggtcggctga taatgattta tggaaatcgt 3060 gctcatcgcg tcgccggtca tgtgaaaagt agtatgtgtc aaaaatataa tctctattgg 3120 gagaatatga ttgatatacg gttaaacgat ctttaaccga tatagtgcta ccaattttat 3180 atttatcggg ccatgctttg tttgacgcga tatatacata tccttcttta attccagccg 3240 ctttattacc attacgataa tacttaacac gcaaaaggga taagcgagtg taattcaatt 3300 gagtagctat agctttgaaa tagcctcgat ttcgtttgat gtgcatcaac ttagttgatg 3360 ggtatatgta tttaaaaaat acgagtttta ccaaatcgtc ggaaatttca aaatcggctt 3420 gattgatacc ttcatttatc aaataattat tgtatcgttc aacaattgaa tttacttctt 3480 cttgcgtcat aatatgaatc tcacataaat tgattttggc ggttgattcc cgactcgaac 3540 gggagacccg cgggttaaca gtccgccgct ctaaccaact gagctaatca accccaaaat 3600 caacttgttt taatcgatga gataataata tctcatttcc agcaactatg aacaatatgc 3660 ttcagaatta atggatgctg gtaggattcg aacctacgat acgctttcgt atgtcctgca 3720 ttaggaccgc cttaagccgc tcggctcaca gcacctcaat ttggaggaag atatccgatt 3780 cgaacggatg agccgtattc ctacgactgc cggttttcaa gaccggtgcc ttaaaccaac 3840 tcgggccaat cttccagaat tcttttcaaa tcaaaacact tcctgcgtca ctaggatgag 3900 agttctgtcc acttaaggct tgctccagga aaaccatggc ttttcaccat ttatcccatt 3960 caagactgaa tgcgtgtttt gattcgataa gttaataata tcttatttcc aaagtgtgta 4020 aacaatatgc tttagaaatt tgaatttggt gcaagtagtg ggactcgaac ccacaatccc 4080 gaaggcggga ggttttaagc ctccagtgta taccaattcc accatacttg cataataacg 4140 ccaggtgctc gggtctatgc ttccccgttt accgatagcc cagtccatcc gccgtaactt 4200 aatcggttca gtattaagga tgtaaccgct tcgcttcctt accgcatcgc gctcgacctt 4260 ttgttatttg gtatatctat ttatgggtgc ctggtatgtg aatttttgct cgatttcagc 4320 gataacttca gaacgtttca cactaaatca cttatattca gtaactacga tatcagcagt 4380 ctcatcgact tcttcgccac gcattcgaga ataatatgga tatctgaaat cgacaccgtc 4440 gccttcgatg ccttcatcat gccatgcttc catgagatgt tgttcacccg aattgcacat 4500 ataagaaatg aaccattctt ttaaatgggc cggcagtttt acaacgacag tttccaattc 4560 aaatctcctc agctcggctc tcgagctctt tttctaaaag ggttttgcag aaattccaaa 4620 caaacgtttc ttttccattg tagatatctt gatcaaatgg gcacaaaccc caatgtacag 4680 tcgagttaaa tggaatatct aatatatcag catcccacga atcaaaatta gcgtacaacc 4740 actctttcag gcttttccac gatttgaacg ttttttcttt accagtcggt gaaatagttt 4800 tcattttgcg ttctcaaatt taccaaagtt caatctttaa tccgaacatc gtaacaactg 4860 gtgttacgct tgtaacaaat ttgacgctcg gaataggggt atctaccgaa atatcaatgg 4920 cggcgagcgg ggctatccca gcacccaaat caacaccatt ataccatcgg ttattggcat 4980 attttgtccc atatcgataa ccggtcataa aaccaacgcg ataaccaata tcaaaaattc 5040 cataagtgta aaatgtgtca gaataagcta actgaaccga aggtttatta atcgagtttt 5100 tcgacgtata tactattgaa aagttgtcaa tttcgacccc tatcgccgga tgtttttcat 5160 tcatttcatc attttcgtaa tgttttgaaa aaccaccaat tatcaaattg gttgaatctg 5220 cgatcgcata agaagatgca aaagcaagag ccaaaaccaa aacaattttt ttcattttac 5280 ctccttcggt attagtattt cagcacgcgt tattgattcc ctccacagcc aatttcaatg 5340 ggtattatag tcaacccatt gtcagaattg tgttgtttct cacagagtgt attgatgttc 5400 tgctgctact tcacgagcaa tcttttccat attgcggaat tgtgccgtgt catttttgaa 5460 ggtgcaatca atgaccttgc catctttaaa catgatatag caatgaaatc cttgagtttt 5520 atgaccgcga atcatgtcaa cctttgtaat accgttaact ttcgcgatat gttgcgggtg 5580 atagattttc atttaaatta ctccgtgttg attttatggg actatcataa aacacagtcc 5640 catcaatgta aactaatttt tgtaaatttt atcgactacc actttgacgt aaatgaattc 5700 aattagcttc cacagcaaga aaagaactac aggtagccat gctgctgcaa tggttccata 5760 aatctgtatg gttgataggc tttttgctgg aaactttgag tcgggctttc ctcgccgcca 5820 ttcgtcaaag aatgcataac catgcagcaa aacatataca atcagtgcaa cagccgtgta 5880 ttgaacgcta actgcaaata attcaaataa aaattgcatt agataacctt aattttaacg 5940 agatgtaatt ctggaacaac gtattcagac gcgttatatt cgatttcaat agactcgacc 6000 acacgaataa aatcgaagtc atactgtttg gcataaccgg tgatgttttc tttcaccatt 6060 ttgcagaaat tgtcatggct gaatgaattt gtataatcgc catcaagtgg atcatacata 6120 tctggtgtca accctagata gtgtttgaat tgcaaagaca aatgcatatt ttctacaaaa 6180 atctcaaaca aatcagcggc catctcagga ttatagtctt tgttgccata acctttattc 6240 tcgatgccat gacatgactc gaaaatcggt ttgattttct caaagaattc gacatctttc 6300 attggtctgc cagtatggat gacgtcagcg taatcatcgc cgtcattttc ccaggaagtg 6360 attttaatga cgtatccttc tggaattaca gctccgggcg caaatttcat tttctatacc 6420 tcaagtctat gctttgtgtt aatcgagctc aattgttctg acaactcttg caatgccaac 6480 gttttccatc acaattccaa aggcgtaaag tagtcccatc caataagacc atcaagatcg 6540 tcttcatcta agccagtttg ctctttcata tgtttcataa ccatgatgct aatatgagca 6600 gaataatcgt ctggcggcat atctgatgga aacacaatgc gacaaacttc ttcgttgttg 6660 tttcctccaa aactaccact tatatcatat tcacaccaga ctttaaccaa ttcggatgtt 6720 ttcggatgta aaaatgtttc ttgctgatct gtcatttatt ttttccaatt gtatctgcat 6780 aaacacgaaa tggaacaatg tagctgcata atgcagttat caatacaaat ccgcattttt 6840 ggcctattgt ccaaacaaaa ttccatcgga atgttgatgt tgtatacttt atcacattaa 6900 tagccaaaac tgtacatgtc gctaaatatg cgatcgcaaa ataaaacaaa aagatttcca 6960 taacttctcc gtatagttac aaaaatgccc tccgaagagg gcatttgaaa attattcagc 7020 agcttcgaca gcttcaccca ggaggcgagg ttcatgaaca ataacatcaa ccagttcact 7080 gcgaacttca gcaactacta cgcgtttttc gccttcacct ttgacaagag cagtgaaaac 7140 agggcctact tcaacagaaa cagcacggcc ggatacagtc agggtagaac cagtggacag 7200 aattacttgc ttttgcattt tattttcctt aagtttgatt agttttcatt tctgaacaac 7260 gttttgttca tgaattcata gtacatcaat tttcgcaact ttgaacatta agtgcttttt 7320 gctttaatct tcacgtaatt cttccacata ttcgtgcgat gttacgatgg ggaagttgta 7380 tgatccttca tacttaagag gaccaatgtc ttttgcaatc gtgatgtgag gaatgtattc 7440 gtcaaaatca tgcgctgacg agccaaggat ctggccatac gcgtgtcgtt tttgcatgta 7500 cggagaatca tatgccagaa caagaaaatt cttttctgga gtttcaaaaa ttctcagata 7560 gcaactgtca gccaaatgtt caggtgaatc atctgggata aatggaacat atactctgct 7620 ataaacgata gtagaatgaa gttcgtctcg aggaacagga tttggcaatc tcagttcttc 7680 ttgaatacgc tggataaaat ccagcgtttc atcactaaat ttacaagcaa cgtatgttcc 7740 tacgaagctg tctgtaaaca ttattcttct accacttcga cttcttgaga aggaaccaga 7800 gcttctactg cttctacaat agaagaaagg gtaatactat cttcgccatc agccggggtc 7860 acacccacaa tttggacgat tttggtgagg gcatctgaaa attcttttgc ttgttgttga 7920 gtagcagtaa gttgctcgct cagatcaaaa actcgaattt tcagggaagc gatggtttgt 7980 tgttcagcgt tcattttata tccttagggt ttagtgtttt tacgaaattg ttaacggatt 8040 catgcaaatc ttcaagtgtt ccagtgttat caattacata atcaccggaa tgaatgggaa 8100 gacctgcttc ggtggaatga gtatctactg aatcagtatg acgaataata tgagcaacta 8160 ctgctcccaa ttctcgcatt tctgacattt catggtcttg tcgacagtca gtaacaacga 8220 cattttcgtg attcaatagg aaattttcta gatattgcaa ccatatacgt ttatttattg 8280 cgcaaccaat gtcagttcca aatgtttgca tcagccgacg aattgaccat gctttcttat 8340 tgccaagaac tgcttctgaa ataattccag tatgcgcata tgtgtaatcg atttgttggt 8400 catcacatac aagcatccat gcagatcgca taattctaaa aacatctgaa ttagaaatgg 8460 gcaaatattc ttcacggtca taaccaagac cgttaaaatc attcatattg aaatattgga 8520 caaacatcgg caatcgattg tcatcacgga ttgcacggta caggaaagtc ttgataggtt 8580 ctgctaaagc gtacttatga aaaccttctt tttccaatag atcgcctact gtgtcttttc 8640 cacatctctt tttcgccgat aatgcaatta tcattgttat actctcaaag gtcgtattaa 8700 ttcaccatct ttttcaattt caaaatattt gaagaaaaag gtaattgtaa atgtcacaga 8760 aacatcgcca tcctcagtgt aagaatactc tatttcaccg atttcagatg gccaagcacc 8820 atgataattg aatgaggcaa ttatatcacg cttggagtta ttaagaacat gaagcgttat 8880 tgctggcggt tggttaaccg ttccccacat agtaggagtt tgccgagcat agtcgttcaa 8940 tgaaagcatc catctgtaca tttcggtata tgcttcaaaa tcctcatcga gcaacacgcg 9000 aacaatcaat ggatcaaatt cggttgttgt actgggcacg ttttgtctag cagttccctg 9060 cgaatttaat ggcatttctg ttggaggtat acgaaaacct ggtattgatg ctgattgcac 9120 gttcatgagc atggtcttaa taccagcaga tgacggtata tcaagcgtaa agttagtaat 9180 attcgattga ttgtttaaag ccattgtaaa actccataaa aattaaaacc tgtttacagg 9240 tttgagcttg ctcaaactta tctttttatc cttttagtta taatatctat taagccataa 9300 aggataaaaa tgaatgattc aagcaagctt gaatctggca agccagtaac ctttatataa 9360 ctggatgcat acagggttta accggaatca ccctgctaaa cttgttacgt cgagatatat 9420 ggtttattga tctataaaat aaaatggccc agacgaagtc caggccatta ccattaagca 9480 cgtgcccata cctttttggc agagtatcgt ttgcctttcg acataaactg ctgcagcggc 9540 atgtaaataa cgttcaccca gtcgctaggt ttcacttcta gcattgaacc ctttaaatga 9600 gctggtaaat atgcttttat catgacgtcg gaaccattca ttcctttaac attcgaccaa 9660 tttattttca aagtcgtttt attggagagt cgttcggtat ttgcataatt ttttagcaat 9720 tcttctaaaa agctttgtct agcttttgga ggaatatagt gcaggttcaa gccatacatt 9780 aaggggcctg acgaagttgt gcctattccc aaaaataaaa ttagcgggaa tctatcccaa 9840 tattcgagag tatctttatg ctttgcatca tatgcgaaag tgtaaattct ccctggtttc 9900 gggtttgata ccatgtgacc gcgaattgat tttttgacag tatcattgaa ccatttttga 9960 gatttattat tgtttgctgc tccagtatca gctgctctag aacgcagttg acttctgaag 10020 tcatttatca tgactaatgc tttttcgcgt gcatttaatt ttgctttatt ttttagactt 10080 tcgacttcta tagcaatatc aatttgcttg gcgaatttaa gcatagttcg tctaaatgta 10140 tcgtaattta gaccctttga tttcgcaaaa tcctttccag acacaccttt ggattttgct 10200 tctctccatt ctattcccaa ttgcacccat tggtttcttg actttttctg tggagcttca 10260 ttgatatagt caaaaatcat ttatcctctc catccaaaat gagttctaag agaattttca 10320 gttattatct taaaattcca acctttttcc atacacaggg catgggcagc tttccactta 10380 tctgtattca cttgccatgt gtacatttct gccataaatt gctttttggc tttcgcagta 10440 ttcgtagact tcatttgggg aggtctgcat tccttttctg gttttacttc gaacaggaat 10500 acttggccgt ttgacatttt gacccaaaaa tccatgaaat atcttcgtct ttttccgtca 10560 gcattcgaaa agtacgggat tattacttct tcagaattcc atgctaaaac tgaaggcgac 10620 tggtcgaaaa atttcatggc ccaagcctcc cagcttgagc gatacgttat tttatcaaca 10680 ttgcctttat atttcccgat gttttttggc ctaaattttc cagaatatgc cattatctac 10740 ccctatttac ataatctcgc aaattgttag cccacgtgtt ccactcacca actacctttt 10800 gtgtatacgt cttgtttatc acatatctaa ctggttcgct tggaggatta cctggctcag 10860 tcggcgtaac aacgtcgtat gttaaaataa caaggtatga atattctttt tccattactt 10920 ttggcgcaag aaaagaatac aaatctgttg tttgcggatc aggcaaatct tcccatttat 10980 ttgcagtttc tctttcgcca gatttgagac gataagaaag acctccgtcg agaacaaaaa 11040 ctccagtgta ttgcccggaa aaagagctgg ccgtcacagt aattccagcg ttttggtcta 11100 ctggattaac ggaaatagaa accagggttg cccctggttc agttaagttt gcgctaaatg 11160 tctgcgatac tatttcattt tcccttttaa ctggcaaaac ggctgatgct ggcaatatat 11220 ttgacatgaa ttaccccaag tttattctag aaccatcaat tgagaatgtt ccttgtgaaa 11280 catcggatac ttgggccgac tgtctattcc aattaccaga aacatcatct gtcctacttc 11340 ctccaacttc agtagaaaaa tttcctccaa ttttcagagt gtaatttcca tcaatcgtgt 11400 taaaacagtc acccataact ttaatatcgg cgtttccatc aacatccgca tttagatttc 11460 cttttactaa cgctgttgaa tttccggtga catactgatt gacattacct tctactcgct 11520 cgtcaacatt cccacgaacg aattgggtag catttccaga tattgtgcta ttagaatcgc 11580 cttggacaaa aatatcagca tccccgtcga caacgatctt gagttttcca ccaatatgaa 11640 cattcccatc gttcttgact atatagaaat catcaccaat aattttcgtg acttttgttc 11700 catcgggatg tatttcttca aacgtacccg tccggtgata tgttcttatg cgttcatgcc 11760 caggtgtatc atcaaattcc tggatgtgac cagactcact ttcatacact ttgttatatg 11820 gatatacagc cgagtaaggt gattcaggct cagtgaacga gggagcttgg gcggttgatg 11880 acacacttgt cattttgaac attctcatcg tccgcaatga cggtgcagat ccttgtgacc 11940 caccgtatgg caccaagttt ccatttctca tgacttctga cacacgccga gctcgtgatg 12000 gagtttgtct agcccataac gaatcgagag cagcatcagc tgcgttatcg tattgaccta 12060 gtgccaagta tccaagcatc atattgaaat ttgctacgcc gccgacaccc atttggaacg 12120 tcatattgac aatagccatt ttacgagtgt cgtctagcat cgaatatacc gggccgacct 12180 tggcattgct tgatatgcta gaatagacgc tggaaagatc acgttcgaac agcatagagc 12240 attcttcttc ggttattctc ccattaactt gcctgcctac ttgttgactg agcaattggt 12300 ttattcttgt catatttcta gttttctcgt gaactatcaa atgacctatc ccaacagttg 12360 gatatccttc actgtcccaa taaaccgata cacgaatacc ttcgtcataa cgtagcatat 12420 cctctattgt tacgtctgga tctggatttg ggtatatttc gtcatttggt gttctatctg 12480 cgccttgtgc aacatctcgg ttgagatttt gatcttctac gacaactgga acaatttggt 12540 tttcttttac aatttggcct ggtgagattt ttatttcttt tccacctcta gccaaaatat 12600 tcacatctga cccgacgtac cgaggatatt ctcttgacgg gtcagaaaaa cctttattga 12660 aatcaggcat cattggatat atgcctggat atgtcccgag aactaggcca ttttgataaa 12720 attcatccaa gaaaattccg tatacgtgag taccggtcac gatgcctact ggagcctggc 12780 ctacacccga aactgacgcc gatgttacag gcatgcctac tgacatccac agcaaatcct 12840 cggttgctaa accatagttg tctgctctaa ccttttgttc tgggtgaata ccgtggacac 12900 gcactctcac ccttcctaac atgtacggat cctgacgatc ttctacgacg ccagtaaaaa 12960 atctatcaat accttttaac attatgcacc ttaaaccttt tccatttcac gtatcatgtc 13020 gtttaggaac gagttgatat cagcttcgct aattatcaga atttttcgtt tctgctcatt 13080 gaccgcagat tgagcttcaa tggaatcaac ggcccgaagt gctccaatgt attgaatatg 13140 cgatctagat gtatctccag catcatacca atgtctcggg aaatctgggt cttctaccaa 13200 attccaatac ttttcaccat tggcatcaac atgatatacg accttatttt ctggatattg 13260 ttgctgcgcg taatcatatg cagcatcttg tgttgttatc catccgtaaa atgggtcata 13320 tacatcgttt agcattagca aaacccaata tagctgttga ttaccataaa gctcatgtgc 13380 caacatttca ggtcttgttg aaccatttat ccaatacact tcaggcttgt attttacgat 13440 aacacgatta aaatacgctc tgtaattctt aaaaatatca gtgatagatt taccctgata 13500 atctattggg tcaaaaaatg aaaaaatcat atagttacac tcctgtttat tttatttaat 13560 gcctcctggg agctcttaaa tagaatcaca taggagggcc ttttatgcct ggattgacat 13620 acgatatggc ttggacaact ggccatgaca catatcctcc tacacaaata caagccacgc 13680 agggaaaagt ttttgttgac ggtataaagg tcgttgttga aggcgacaga ataatacctc 13740 atcgaaacac tgttgagcct tatgatgttc atgacggcta cgttattccc actacggcga 13800 aggtttttgt tggtggaaaa cccgcagtat caattggtga tccaatatct tgcggagaca 13860 caattgcaca atcatctagt aaggtgttta tacgatgaaa ttgaaaacaa atatcccaga 13920 tatttttaaa ggcgctacct ttgacgaaat caaaagcgac ttaattgact ggttaggtaa 13980 ccaggatgaa tttaaagatt atgactttac tggttcaaga ttaaacgttt taaccgattt 14040 gctggcatat tgcacactct atattcagca attttcaaat tcagcattat tcgagagttt 14100 tatccgaacc gctgtattaa gaagttcagt tgttcaacat gctcaggaca tgggatatat 14160 gccagattct cgtactgctt ctagtacgac tctgctgctc aaagcgacaa acccgttgaa 14220 tcctaccagc attcgtattc cgagaggaac taaattcgtt ggtacggtgg aacgtactga 14280 taactaccca ttcgttactc ttgacgatgt tacaataatt cgcggtcaga ataatactta 14340 cgaatccctt gtagacgtgt atcaaggacg aatagttcga actgagttga aatttgatgg 14400 aattagtcaa attttgattc gtgaccccaa tatcgacaga tctaaagttc gtgtatgggt 14460 agatggttcg ccatgggtcg attggactaa taattcaatg gttgatattt ctggtgtttc 14520 caacgtattt tatatgcgtg agaccattga ccagaccact gaaatattct ttggcgaagg 14580 tgaagctagc accgaaatcg caggcggggc tctcgtagca aattacattg gcgggctcaa 14640 accgaatatt ggatcaacaa ttgtgatcga atatttgagc actcgaggtg agccagcaaa 14700 tgggtcaaga gatttcgcat atactgatac tcttcaaaat atcgtcataa ctgatctgat 14760 tgagaatccg actgatgacg ccgattatgt gggtactcag ggtggcggtg atcccgaaga 14820 catcgaaaga atccgcgaac ttgccccggt tatgagagaa tctcagcgca gatgtgtcac 14880 tgcaaccgat tacgagtcat ttgtctctca caagttcggt tcaattgttc aagccgttca 14940 gtgcttcact gacagtgaga aaagaggata cgcgttcatc gctattaagc caaaacaagg 15000 gcttagatta acaactgtcc aaaaagaaga cattgaaaat tatttgtcac aatataatct 15060 cgcgcctatt acccctgcag taatagaccc aaattatatg tacatcaagt caaaaatcaa 15120 agtgacatat aacctttcag aattgtataa ctctgaagaa tggcttcgcg ggcaaataat 15180 tgattctatt gaccgctatt acactgatga agttgaaatt ttcaacaaaa acttctctaa 15240 atcaaagatg ttaacacgtg tagattcgtc ggatgattct attatcggct cttctgctga 15300 aatatctctt gttagggaag cagataattt cttcaaaact ccaatggctg gaatatcttt 15360 ccagaatgct atttctaagg ggtcagtcaa tagttctaca atcaacttca caaagaataa 15420 cgtaacgtat gaagttaatt acgtttctac atcacaaact gataaaattc tgattgggcc 15480 atttgctaat ggcgatattc ctacatcaga gtactctggt aatgatttca caaaaacaac 15540 agtgggtgga agaaacaagt attacgaggt cggaacagta gattactctc tcagtgttat 15600 aaactttgac cttggtattt tacctgtacc ggcagaatca tttgctggag catatataga 15660 aatagaagca ttaccagttg atgacactat ctttgcgaaa gatggaactc ttatcgtatt 15720 tgagaatgat ttacgtcaac agtacactgc tattactctt gaagcaattt cacaataagg 15780 gcctaacggc cctttggaga ttttatgatc ataaaagcac ctgtcgtaac gagccttaaa 15840 atcaaaattt tatcggcgaa tcaagtatat ttgacttggg acgatgtagg ttcaaatttt 15900 tactatattg tcgaacttct tcagactaga gcagggtctg gaaccagttg gggtcaatta 15960 ggtgtaacat cggtcgaaga atggtttgaa gacacatcta tacaagcaga cacttattac 16020 aaaatgcgag ttcgcgtttc tggaaaagga tttgagatgt ctgattgggt agaaactgag 16080 gagtttcaaa ccttttcgga aaatgcctac tacatttctg ccatgaaaga attcacacct 16140 gctgcttcct tcgtgagaga aaagttctct aaaaacaacg aaaattacgt caatttcaat 16200 actgatgtaa ttatggcttc gttaatgagc gaagatttcg ttttcagcaa tcaatttact 16260 gatgcgacga atctttatga caaaatagtt tcaaatgaaa actatcacga aatacaaggc 16320 tttattgagc cagtgtgtgt tgacaaaaat agaacaatgc tagctgaaat tgacgatgtg 16380 ttgtatctat ttgagcgttt tcagccaatg gccaaagtgt caaatgacaa agggcaaaac 16440 tggaaatatt acaaagcttt caacgggcgt gtaggcaacc cagttagtag aacagtaaca 16500 tatcaatcta gcactactac atatcttctt gggtatgaaa acatctatta cggccgtcgg 16560 gcaaatgacg tcagatggtc agctgatgac gtcagattta gctcagatag tgtgacattc 16620 tcaaaaactg gtgatgaact gaatcttggt tttgatgttg aaatattcaa ctcatacgct 16680 cggcttcctg gtgatatttt taggaaggga gaagctattg ctgctgatga cgattgggta 16740 tatgtggcag ctagaaataa gttgcgcaga atcaaaacat ctaatgcccc aattgataat 16800 gatccaggta gtccgacatt tggcgagaaa ctttttgacc caaccgtttt caatataaca 16860 gcaaacgcac gggctgttac gaaaaagctt gatacattca atggcaagct ttatgctttg 16920 attaccggtg tagttattca agccggtctt gacccaacaa agcctgaaaa tgttgttcat 16980 gacccagtag caggtgtcta tgaatttgac ggttcttcgt ggaaaaaagt atttggcatc 17040 ggtgaagacc atgtctggat atcgcacgac tatagcaata tgtcgactaa tggagaagag 17100 gtatttgttt ctcaaataaa cttcaaatat cctggtactt tgcctgatac cgatttgccc 17160 gctagatatg acaatgtgtt tgaagctgta aagtatgaat tagcacccgg ctataattct 17220 gacattccaa ttcatatggg tactttccgc atcaatgcag acgatccagt atggaaactc 17280 ggaccacagc aatactataa tgaggcagca ttcaactgga tgggccgctc tggtacaaga 17340 tgctggataa caaataacga ccgtgttctc gtggtttacc caaaaatcga atattcattc 17400 tctatcgacg acgaaggaac agaaagtgat aaaagggtaa acagagaaac tcacaacaaa 17460 ggtgttgtaa cactgtatgc aaataacgta tactttaccg gtttcaaaca atatgccaat 17520 ggggtacttt tccataaaaa tactggcgaa ataattgggt attatgaatt cccataccgg 17580 gtaagaaata ctacatctgt tttctggaag ccggccaacg tcatgatggt agctgagctc 17640 cgcaatcaag aacgcgaagt tccatggaca cccgcgccat tcgtcggatt aaaggatcct 17700 gaccttcagc cacttgttac taaaatgatg cctgaaagtt atttggacga agataccaat 17760 tttggtgcat ttgcgaaata ttatctgcaa ttcttgtcgg acggaaacgg gacatattac 17820 aacaaattgc tcaatttgat aaaaaacaaa taccctcgcg agcaatatgc gtatgaatat 17880 ctttggtcag aagttttaaa aagaaacatc tatttggatg aagctaagcg agattctgtc 17940 gcaagatttt ttgaatctcg ggcctacgat ttttattcca caaaaggagt tgaacaatca 18000 tataaattcc ttttcaaatt gctttataac gaagatgttg aaatcgacat cgagtcaaag 18060 catggaatag aatatgacat cgtagtttat tcaaccaaca taagccaaga tattgttgga 18120 agaaccatat atactcctac aggacgtgca aacgtcacat atgtggatcg tgagtatgtt 18180 gaaggccaat tgaaatggag aataaccatt cacaatatga ttggtaaatt ctttgaaggc 18240 cagcaaataa aatccgaaac tagttcgttc gtaggtgaaa tattggtagg ggttagagga 18300 aaggagctta tgagcgattc gattgactat atcaatcgag gcagatcata ttacaccatg 18360 actataaagt caactcttcc ggcgtctaga tatgcacaag atgttctccg ttttgttcat 18420 ccagttggtt ttggatttgt tggaataaca cttctcacga tgttcatcaa ttccggctta 18480 tcgatgaaac atgtagaaac tatcatcgat aatttgaaaa cgtatcgatg ggatgctggt 18540 tacccaactg agcaatatga tcgcgtagcc aaattggacg ttgacgggaa tattgaacat 18600 gattccatca ccggagaagc tttgtactta gttggtccaa atgccgggga accatttgtt 18660 cctcctcccg aatatgacac cgaagaagca tcatggctag gaaaactgcc gtcggaacga 18720 agattcaata tgagcccgtt atttgaccag tctgctgtaa cgttctcaca tttcagacgt 18780 ttggtagaaa aaaggctaaa agatgacgct ggaaatccgc gtgaccaaca aaatccaaca 18840 caggtaaaaa tagatgagta atttctatcg tgctattgtt actagcaaat tcagaacaaa 18900 gaatctgctt aacttttacg acatggtggg cgatgagccc accaaaaata caatatatgc 18960 aacattcggc cgggacactc cttggtcaac taacgaaact gatgtaggat ttgccccgcc 19020 ttatccaaac gattccgttg atggtattgt tgacatgtgg acaaacatgt taggagcggt 19080 aaaaattgat aaatctttgc ttgatgctat aatcccacga aaagattggg gagatatcag 19140 atacgataac cccaagacat ttttcattga tgacatagta gtagtaaact ctgcaacata 19200 taaccgtacg gacagttcag ttggttggat gatttatcgt tgtgccgatg ttccttctat 19260 tgggtcatgc tctatatcag ggatagatga caagatcgag tgtattacga taggcggaaa 19320 atggacagca actcatgaat ctgttgagcc tcctcgtggg actgctatgg caatcgacat 19380 gggtgatggt tatgtgtggg aatacttgta cactattcca ccagatgtat caataaacag 19440 atgcacaaat gaacatattg ttgtgccttt cccggatgaa ctttcagacg atcctgccag 19500 gtgggggtat gaaaatgcta ttctatggta tccagataag ttagacctaa tttaccgggt 19560 taaagtagac acactccgat tcagagcgta tatggactca atatacttcc ctgaggcatc 19620 actcccaggc aacaccggtt ttcgccagat gagcataatc atcaacccat tggttaaaaa 19680 atctgcgcca gcagacccag acaaaaaggc gatattggca gcatataaac ccaacgaatt 19740 ggaaaaagat tcgggtgaaa tgatatacat ggaaaacaga cagcctatca ctcgagctct 19800 cgaccagaca gaagaaatca atatcatttt ctcattttaa ggaaaacaaa tgttacaatc 19860 tactaaaaag agaattgacg taggcattat aggtaatcct tcaaccggtg atatactcta 19920 tgacggcggt gtcaaactca atcaggttat tgatgcgctt tataacacat ttggcgatta 19980 tagactttat tcgtcagctt ctgaaggagc tgactctcaa attattcacg ccactggata 20040 ttaccagaaa ttatcccggc agtattatgc tggaaatacg ctagatattg gttctatgca 20100 tgatgcagac acatcaggtg gggcattgac tatgaccctg ccgaatgcaa agcttgggga 20160 aggttgcatc tttataaata gtaatggatc aatttctccc tcgaatcctc tcataattcg 20220 ccctcaagct ggtgaaagta ttttgggaac atctggctct cttactgtaa catctccata 20280 tgcaagagtt tttgtctggt gtacaaagaa cgaaggatca gaaaaatatt gggaatacgg 20340 aataacccca atgtttggaa attcccttat gccagttgaa aaaaccattt tagctacaac 20400 tactgcaact aatattcgta ttgctggtaa aaacgaatat tctgcgataa agttgatggt 20460 tgctgcccga aatgctgccg gtacagtttt taaaaattca gaattcctaa tatcggtaga 20520 tactgttaca aatgcagttt taaatactga gtatgctgtt cttaagaata catctaacga 20580 attgtatgaa attcgtttct ttattggtgt aggtgataac gtctacgctg aagtaaaatc 20640 tctcagtggg caaatacgct tttcaataaa agccattgac acaattaata ttggggcaac 20700 atcataatgg aaataatcaa aatcggaaac gttgttgatg atggccaagg cgattatctc 20760 cgccgtggtg ggcaaaaggt caataacaac tttaccgaac tctattcaca actgggcgac 20820 ggagatcgcc cattcgctgc aggcgcgtgg aaaaatcatt cggtaggagc tctttctcca 20880 ttattcggag attcatgggc aataaacacc tccgctggtt ctattactgt caatttgcct 20940 aaaggatctg tttccgacta caataaagca ataaaattgc gagatgtgtg gggcacatgg 21000 gcaagccaaa acgtaatttt ggttgctgct tcgggagata cgttaaaggg ttcaccaaat 21060 cctcgtaatc ttgacaaaaa tttgatggac gttgagcttg tatattgttc gccaggcaga 21120 tgggaatatg tagagaacaa gcgtgttgat aaaattacaa catctgattt gagtactgtc 21180 gccaaaaaag aaatagttgt ggctgttgat ggtcaaaccg attttcctaa tgtgttcggg 21240 acaacaaatt acaatattgc aaacctcgaa gtctatctac gcggtaactt gctgtattac 21300 ggcgacacgt taaacgaaaa ctcgaactat ggatctatcg acccagccaa ttcgacatca 21360 gtgctgccat tagatggtag aagtattcga attcgcgata ttgacatcaa aaagggtgat 21420 accgtaacaa ttgtcaccta catggacgga atcgcttctt atcggagttc atataacctt 21480 aagaatattc agatttttga tgcatcaaca acacagaaaa cgtcatcgcc tggtgaaatt 21540 tgggttggag atatttcggc aaaaactgat ttcactattg atgaatttga tattcagcca 21600 aacaatagaa taaatccaaa ttcgcttgaa gttcttctaa atgggacgat gcttaatcga 21660 gcaggggcgg gcgatttgcc aatgttcatc tgcgagaatg caattggcga tactcagcaa 21720 atgtgttggg gtaatggtgg caactggatt ccgtcatcta ttgattattc tatcgtattg 21780 gatgacgacg gtaatattac cgatattaag ttcggaagaa cgtttgaatc tggtgatatg 21840 atcaccctca gatggttcaa taatgacatt ggtactctgt tggattggga aggaacaaac 21900 ggcattaaag aaaaagctga tttgatttat ctcaataccg aacaagaaat atcaatccaa 21960 aaccagatcg aatataccga cttcgacaat cctagccaaa gcacggctca agttattccc 22020 ggaattttca atgggagaat cgaaaatatt cagcagatgt ttgatatttt ctatccaatc 22080 ggaacgatat acgagaatgc taataactcc gctaacccgc gtgattacat gggatttggt 22140 gtatggaaaa gatatgccga aggtcgtttg gttgcagggt ggacgtcaaa tcaagcggat 22200 gttgaatttg gtttaaacaa taatgatctt gacaatctcg gtaatcccag tcatactgca 22260 ggcggaacat atggttcaaa atctgttgaa ttaattcctc agaatatacc cgagcttgtt 22320 tcagttgata aagttttggt agcaaatgat ggtgggaata ttattatcgg cggctgccag 22380 gtcgaccctg atgcatctgg tcctggctat acaaaatacg tagaatcagt tcttgctgta 22440 aataaaggaa atacatcgcc aggaaacatt aatattcttc ctccgataat tacagcatac 22500 aaatgggtaa gggtgggata atgatttcga aaacatcaga gagtgcacac aacatcttta 22560 gaaaagcaac tcatatcgag tatctgacta aaccgggcac ccaagtaatg agtgcccgaa 22620 atataggtgg gccgacggta gactcattta tcaacggtgt gaactatcca aacgtgcaat 22680 cagctatcga cgaactccaa acattgacaa tgttgcctat taacgcaata tatgcttcag 22740 atgttcaagt ttccccagaa ggtgttcgtc aagccgagat gcttacattt agcggaagtg 22800 ttcttccttc tgaatttaat aaatcagtca ttacagttta tggcatacct ttcattgttg 22860 ccgccggaac taatgccgac gcagtatgtg acatagtttt gacaaaattt gaagaaatgc 22920 gagatgctgg cattttattt tattctgttc aaagacaatc cggcacaaca actcccatca 22980 tagaagtgca attcattgat tcggctgagc atgggaatat tgaaagtttt agcagctggg 23040 gaattgttgt tcaacgtgaa attactgttc ccggaaagcc tggatatggt aattgggaat 23100 atatgggtaa agagtcaaaa actcttactg gtggatcagt aaccggtcca tttgagcttt 23160 actacttcaa gaggattggt taatgaataa caatatcaaa tatcatattt cggattcggc 23220 ggattcggta tttttctctg ggccagattg gcccagttca gttgaaaccg tatcagatgc 23280 attgaatgaa atagcgccat gggcattaac tgttaatgga ctgccgatag caactgaggc 23340 tgtacccggc atcattcgaa ttgctactga agctgaagca tcagctggca cgagtaacaa 23400 tactgttatc accccaaatc ttttgcgaat tgcgatgcag acgcctcagg ctaccgagtc 23460 catcgttggt aatactcgtt acgcaacaag tgccgaagct ttggccttat ctattaacac 23520 cgctgcaata acaccttcga aactggggca tgtcattgca aataaaggtt ctaccgaagc 23580 ggcaagagga acaatccgta tatcgaccac tgcccaagcg ttgtctggca ccgacgatac 23640 cacagctatg actcctctta agaccaagca ggctattgca catttttcag aatcatgggg 23700 aactgcaaca gaaagctcag acggagttgt ccgtttggcc acattggctc aagctttagc 23760 aggagttctt agagatggct atgctgttag tccatatact ttatcaagaa tggcagggac 23820 ggaaagctca gctggattgc ttaaagtagc aacaaattcg caaacattag cattagctga 23880 taacactgtc gttattactc cagctaaact ttccatattg aatgctacta gcactcaaaa 23940 aggattagtt cgccttctta atactgaaag ctcacaagcg aatacggctc tttctgctaa 24000 tgcccaggtg ttgtatcgct cgggtggcac aatgactggt aatatcaatt tcacagaaaa 24060 caatcaagga attttgtgga atagaaatag tgatttggct gctataacat tcaaaaacga 24120 tagtgatgct gacacgaatt cgtatttgct ttttgctgtt ggagacaata acaacgagta 24180 ttttagatgg acaactcgca ccaatggtgt agataccaca attgctacgc ttaggccagg 24240 cggtcattta tggctagccg gaaacatcga cattaacgat atgtatgttc gttgcgatac 24300 caggttaaaa actgatattc agcctatcaa agatgcactc gtaaaaatag atagccttga 24360 cgctgggatt tacacaaaac ataaatcttt gactgacgat actgtgatag gcaaagaggc 24420 aggtattttt gctcagcaat tgcaacaagt tttaccagaa ggcgtcaaaa cacttgacga 24480 cggaactctt actgtttctc caatgtctct catcgcatta ctgattgagg ctaataaaga 24540 gcttaaatcc agattagaaa aactcgagga aaaaatatga tagacaaaat cacgaaagga 24600 gttattcctt atgttgatac tactccaggt gatggtcaac ttcgaattgg ttggattaaa 24660 aacggagagc ggctttcggc cgcttccacc caaacatcta acgatggtgt ttacaacagg 24720 gctccactta atattcaaca gaacgttgtt cagttagacg aagaccaagc ccagtcattc 24780 ttaaaaatca atgagattgt cgatgcggta aatattatcc aagataactt gggcgcaatc 24840 ggtgataata cggtaattga ccaaatcaat gctaattcta atgatatttt agctatcagg 24900 caagatatta gcgaggttga aactaattta gcagatgttc tttctctttc agaatcaaca 24960 tcggaaaagc ttggccatcg atatctcgaa gacaacacaa ctcgaacagt atacggcgat 25020 ttgtattgga taaaaaccga attaggtgca tatccaggct tcgacacaaa cggtaattct 25080 gttccttctt cgataggttc gggattaaag tatcggttta gtcaagtaaa tcaaacagtg 25140 tctctaaaca ctcagcgtat aaccgcgctt gaaaattcat gggcgcagtc agatgtaggt 25200 caattgacgt ctgatttata tgatttgagg atggaaatcg gtaatacaaa ccttgggaca 25260 ggaattccga tttacaccag attgaccgct atcgaaaata ctttaggtgg tggtgatgat 25320 gacgttgatc aaatcaagat aaaaatcgat ttttccaacc ctgtatcgat agcatcaagg 25380 gtggcgttga atgaaagtgc aacgagttct cttgcgaaca caatgaatac ccctgtgaca 25440 ggcgtgttat ctcgtcttgg agcagtagag cagaaaatcg gtgatgttaa tacgcaaaat 25500 acaattttgc atgacattaa tcgaaatacc tctaatattg caacaattac gcagatttta 25560 gggtcagaca gttctagtgg aattcaaggg gatatttcag atctcaatgc cgctattggc 25620 tctatcggag aaccatcatc tataaatggg cgactgtaca ttttacagac aaatcataac 25680 caaatgtctt tgtcgttgaa tgacgttgtt tcacgtgtcg gtgatgaaaa ttcaggtctt 25740 gtttctgcaa acattctgat gtcaaccgac ttgtatggaa atgcggctgg aattacacaa 25800 cttgaaagag atggtatcaa gaaaactgtc aaagaaagca gtgaaactct tcaactcaag 25860 ttagataagc cactcgcagt agggcgctgg tattacgaaa acggtgtttg ggttaaagca 25920 actaacatca tggttgctgt tgaaaagaaa gattttcaaa taactacaac tgaaacgtcg 25980 gagattattc catttgttga ttttgatcag accgtagcaa acggttgcat atttgaatcc 26040 ggacaaatca aattcgctga tggcggttta gttaatgcaa gcatcgaaat tgaaacatct 26100 ggtttgttag aaacagataa tctggaaatc tcaatagctc atacaagcgg cggaattaca 26160 tcatacacca atttgcaaga atttaccctg agatcaaacg gtagactcta cgcacgcaac 26220 cggctgtaca atgtgatttt ggatgatact atcgcaattt atgtcaaagc acttgactca 26280 agttcagcta aatcgataac tatcggcaaa atgtctgctg ttattgtccc agcataatct 26340 caaggctcct tcgggagcct ttattgtaaa taaaacttat cctttatggc ttaatagata 26400 ttataactaa aaggataaaa ttttcgagct agctcgaaag gctccgccat aatttgctta 26460 aatatcataa aggagacact tatgtcatat accactaata acccgttaga attaaaggac 26520 gctatactta gacgtctagg tgcacctatc gtgcacgtcg aagtaacaga gcaacaagta 26580 tttgattgca tatctagagc tcttgaattg tacggtgaat atcactacga tggatttcac 26640 aaaacatatg caacagtagt attaaccgaa gaacaagcta aaactggtgt aattagtttt 26700 gcaggtggca atgtttttgc agttactcag gtaattcgaa ccaatattgg gtcaattata 26760 accatggacg gcacggctgt ttatccgtgg tttactgatt ttgttatggg tatgactgga 26820 gcttcaattg gcggccaatg ccgatggtat gggcctaatg cttttggcgc agatctcgga 26880 tatttcactc aattgatgtc atatcgagac atgatgggag acatgctttc tcctttgcct 26940 gatttctttt tcaacagtac taccgaaatg atgagagttg ctggcaaatt gcaaaaagga 27000 gatttgctgg tatttgaggt ttactgcaaa tcgtatgcga atgttgactc aatgctttca 27060 ggaacttcgg ctggatatgg gtttgccatg tcagatgacg atagcgtgcc gtcggtggcg 27120 caaaaatacg caaatcctaa tatgtcacat ggccaaattt atgcaggcca acccaacggt 27180 atgacaaaag ataattcata caataatcgc tgggtaaaag acatggcaac agctttcgtg 27240 aaagaactaa acggccaagt tttagcgaaa catcaaggta tgcagcttcc aggtggtgta 27300 acaattgacg gaatacgcct gattgaagaa gctagaatag atatcgataa gcttagacaa 27360 gaactcgaat tgctggatgg gcctcctcct attatcatgg ggtaaattat gatggataag 27420 tcactattcg ctactttaga aaatagaagc ggatatcaac aaacaaatga gcaaaatatt 27480 cttaacccgt atgtcaaatt caatcggtat gagggctctc aggccctcca cgacactcta 27540 gttgcagaat ctattcaaat gagaggcttg gaattttatt atctcgaaag agaatataca 27600 aatttggacc ttgtgtttgg agaagaccca aatagcagat ttgaaaaagc atggaaattt 27660 gcggcatggc tcaatagctt cgagtcatat gagggacaac agagtttctt ttctaaattt 27720 ggccatcaac aaaatgacga agtcagaatt tctatcaacc caggcctttt caggcatcaa 27780 gtaaatggaa aagaacctaa actaggtgat ctgatttatt tgccaatgga taacagcctg 27840 tttgagataa catgggtaga accttacacg ccgttttatc agatgggaaa aaatccaatc 27900 agagtaattg ttgcccagaa attcatatac tctggtgaaa aattggctcc tcagttccag 27960 gaaaaacctg aaattgaaga tccatataac ggtttagacc tggagccaat attgaattta 28020 gatggtttta ttgatcaaaa aatcgatcag tttggtgaga atgttcaggc gcaaaatgaa 28080 gctagaccat ttgtagagcc atttgatcca attggtacaa acccagtgaa cagctttaat 28140 agtccatttg ggcggcatga gggacagtaa tgtttggcaa tcatttttat aacagctcaa 28200 tacgccgata tgtattgatg ctaatggaac tttttggtca tattcaagtt tctcgttttc 28260 gagatggcca gcattatttt caagatgttc ctatcaccta cgcaagtaaa gaaaaatttg 28320 taatgtctat tgatgatatt acgatgccaa cttccgaatt caacattgca aaagtcgaag 28380 caattcttcc tagaatgaat ttgcatttga tcgatatgca atataactca atggtaaaaa 28440 ctggaaatac tcaaaataaa tggataaata aacccaatgg gaaagcgttg gcgcaattta 28500 accctgtgcc atacacattc atgtttgaac taggaatatg gacccggcat gaagatgatg 28560 catttcaaat agttgaacaa attttaccat actttcaacc acatttttca tgcacaataa 28620 ctgagttgta tgacaacgaa ataattatta aagggcggga tatcaatata actatcacat 28680 ccataacgcc tgatgagcag ctagatggcc ctggcgaaca acgacgccgt attgaatggt 28740 caatcatgtt tagtttcact ggttggttat atccaaacac caaaaatatt gcaggtgaaa 28800 ttagaacgat ttatcttgat ttctttggca atgaaagaga aataaacaaa gatactcatt 28860 ttgaatcagt tgatcaccaa gttgttccaa aaacagtgcc agctcaagat tgggacggga 28920 gttcgatgga agtatggaca aacaatactg atcagaatac accgcctcga ccacaatagg 28980 aaatactcta tgaatgatct tttagacttc actagtctca aggatttgtc tggtatcgaa 29040 ggactcaacg gggaagacgt gcaggtatac gccccgctgg tcttacaaga accgacatca 29100 aatccaaaca atagaaaaat tgaccaggat gatgactata cgcttgttag acgcaacatg 29160 cattttcaaa ctcaaatgat gatggacatg gcaaagattg cattggaaaa tgccaaaaat 29220 gccgatagtc cgcgtatggt tgaagtattt tctcagctaa tgggtcaaat gacttcaacc 29280 aataaagaaa tcattaaaat gcacaaggaa atgaaagaac taacatcgtc agaaccatcc 29340 atactcggca aagttcaaaa tgatgaaagc ggagaaatta tagaattcga aggttctcct 29400 gatgaattgc ttgaactgga attgggtgat gaagtatgaa tattttcgaa agtgatcacc 29460 cattgcaaat gccccatcca tccacgttaa agagagaaat gcgcgaagat ggggaatgga 29520 ttttatcaaa tcacgatgat aagtggtatc cctcgacatt tgatagatat ctgaaatcac 29580 agggagtaaa gagggtaaaa atccaagcag acgacccgtc aatgtttaga acgtttaaag 29640 ataaaacaaa caagcgttct agatataatg gtttgccgaa tctaaagcgt gctaacatta 29700 aaataaaatg gacaaaggag atgttagccg agcgaaagag atgcaaagaa gatatcgttt 29760 atttcgccga aaactattgc tgcattgagc atattgacta tggtattatc cgggtccaat 29820 tgcgtgacta ccaaaaagat atgcttagaa taatggctgg caatcgtctg atggcagcaa 29880 atttgtctcg tcagctcgga aaaacgacag tagtagctat tttcttggca cattttgttt 29940 gcttcaattc ggctaaaaac gttggtatcc ttgcgcataa agcatccatg tcagcggaag 30000 ttcttcatag aacaaagcag gcattggagc tattgccaga ttttctgcag cctggcatag 30060 tcgaatggaa taaagggtct atcactcttg gaaatggttg tgcgattggt gcattttcca 30120 gttcccctga tgctgtgcgg ggtaactcgt ttgcgttgat ttacatcgac gaagttgctt 30180 ttattcccaa cttcaacgac gcgtggttag caatccagcc agttatatca tcaggtcgtc 30240 attcgaagat tttgatgaca acaacgccga atgggcttaa tcattggtac gatatctgga 30300 ctgctgcaat tacccctaat tcggatggaa gtggaagcaa atctggtttt gttccgtata 30360 ccgcaacatg gtcgtccgta aaagagcgca tgtattcgga tggttctaaa acagatggca 30420 gcgattcata ttttgacgac ggatattctt ggtcagccaa gacaatcgcc ggttctagcc 30480 ttgaggcatt tcaacaggag cataatactg ctttccaggg aacatctgga acgttgatca 30540 acgggttcaa actgtcaaaa atgacgtgga aagaagttcc ggcatcagac aatttcacga 30600 tgtttaagga accaattgaa ggtcataaat atatcgcaac acttgactct gccgaaggtc 30660 gtgggcaaga ttatcatgct atgcacatat acgacataac agaattcccg tacgaacagg 30720 tcgcagtata tcacagcaac accacgtcac acctgatact ccctgatgtg ttgctcaagt 30780 acttaaatat gtattatcag ccatacatct atattgagct gaatgcaaca ggtgtatcca 30840 tagctaagtc gttgtattcc gaactggaat acgaaaacat tatatgtgac tcgtacaacg 30900 acctcgggat gaagcaaact aaacggtcaa aagccatagg ttgttctact ctcaaggatt 30960 taatcgaaaa agaaaaatta gtgctttacc ataaaggcac gataatggaa ctgaggacat 31020 tttccgaaaa aggcgtttca tgggcagccg aagacggttt ccatgatgac ttggtgatgt 31080 cattggtaat atttgcatgg cttactaccc aaccgagatt ttctgatttt accgagagag 31140 atgacatgcg attggcaaat gaaatatttc gtcaggaaat ggaaaattta tatgacgact 31200 atacgcctgt cgttatagtt gacagcggag aagaaacttt cgaagttggc agtaatggta 31260 tgtcgttcgt gtaaatataa agcaataaat aaacatgtgt taaactaact tccaaggaac 31320 caaaatatgg cacttctgag ccctggcatt gaaatgaagg aaacttccat caattcaact 31380 gtcgttcggt cagctactgg ccgtgccgca ttagtcggca aattcgcatg gggtcctgcc 31440 tatgaaattc gtcaagtaac aaatgaagtc gaattggttg atatgtttgg tagcccagac 31500 aatgtcactg ctccgtattt catgagtgct atgaacttct tgcagtatgg taatgatctt 31560 cgtctcgtgc gcgtaattga catggagcaa gctaaaaacg catctccatt gtttaaccaa 31620 atcgaagtaa caattactac cgaaggacaa ggttataccg taggtgatac cgtttctatt 31680 aagcataaca ccacaactgt tacagaagaa ggaaaagtaa ctaaagttga tgctgacggt 31740 aaaattaagg ctttgtttgt tccttcagct gcagtaattg caaaagccaa acagctggga 31800 acatatcctg tcttaggaaa taactggcgt gcagaagtat cgggcgcatc tggcggttct 31860 gctgctgctt taaccttggg taatatcgta gttgattctg gagttacttt tggtaattcg 31920 gaagaagctc cagatgttat gacttctacc gaagtgatgg ctaattttgc caaatatgga 31980 atgcctctga tttcagctgt ctatcccggg gaaatcggtt caactgtcga agttgaaata 32040 atttctaaga cagcattcca aagtggtgca gctcagccaa tttacccgtt tggtggtact 32100 cgcactagca atgcacgaag cgtcattcaa tatggcccaa tgacagatga ccaatttgcg 32160 atcattgttc gccgagacgg catcgtagtc gaatccacag tgttgtccac ccgtcgtgga 32220 gatcgagatg tttatggaaa taacattttc atggacgact atttccgcaa tggttccagt 32280 aatttcattt atgcttctag tgtaaattgg cctgctggct ttaccggtat catccggctc 32340 ggtggaggcg cttcggcaaa tgatgctgtt ggttcagatg aattgattgc tggttgggat 32400 ctgtttgccg acagagaagc tctgcatgtc aacctgatga ttgctggagc atgtgcatct 32460 gacggtgctg ctgttgcatc tactgtccag aaacatgtcg ttgctctcgc agatgaccgc 32520 caagactgtg tagcattcgt caatcctccg tcagaattac ttgttggtgt tcctaccact 32580 caagcggtta agaatattgt cgaatggcga aatggtgtga catctggtgg tgaagttgtc 32640 gacaataaca tgaatattag ctcaacatat gcttttattt caggcaacta taaatatcag 32700 tatgacaaat acaatgatat taaccggtgg gttcctcttt ctgccgatat tgccggattg 32760 tgtgcctaca ccgatcaagt aggacatcca tggatgtccc ctgctggata tcgtcgcggc 32820 caacttcgca acaccatcaa actggcaatt gaacctaagc aatcgttgcg tgataccatg 32880 tatcaagtgt caattaaccc ggttacaggt tttgccggcg gtgacggatt tgttctcttt 32940 ggagacaaaa tggcaactca ggttccatct ccatttgacc gaattaacgt tcgtcgcctc 33000 ttcaacatgt tgaagaaaaa tattggtgat acttctaaat acgaattgtt tgaaaataac 33060 gatgcattta ctcgtcagag tttccgtatg gaagtttcgc aatatctcga caacatcagg 33120 tcactgggtg gcgtttatga cttccgcgtt gtctgtgata caacaaacaa cactccgcaa 33180 gttatcgaca gtaatgaatt tgtagctacg atttatatca aagctcctcg ttcaattaac 33240 tacatcactc tgaactttgt agcgacatca actggtgcta actttgacga gttaattggt 33300 cctgcccaat tagcataatt cagcgttggg cccaaatatg ggcccataaa taaacataga 33360 ggttgataat ggacgtaact gatgtcctca gggcttttga gtccggtgat ttcgcccgcc 33420 ctaacttgtt tgaaattgaa atcccatatc tgggccaaaa tttcaaattt aaagctaaag 33480 caggtacaat gccggcagcc actgttgaaa aaatcccggt tggatacatg aaccgcaaac 33540 ttaatgtggc aggtgaccgt atttttgacg actggacgat tacgatttat aacgattcgg 33600 cccataacac tcgacaggca attgtcgatt ggaatgccat gactcatgga atgggtaatg 33660 aaatcactgg cgatattcca gaagcatata aaaagcctgg cattgttcgt caaaaagatc 33720 gtaatggaaa tacaactaaa gaatatacca ttgtcggtct tttcccgact aacgttggtg 33780 aagttactct cgactgggat gataacaaca cagtttcaac atttgaaact acgtttgcac 33840 tcgactggtg ggaataataa atacaggcag cagtaatgct gcctgattag gagtttgtat 33900 gaagttttta gatttgttta aattttggga tcgtgtcgat caaaatgaat atgacgagcg 33960 gctcaaacaa ggccacgaat cgattgcgac tcctaaaaaa gatgatggtg ccaccgagat 34020 tgaagctcgt gagggagaat catcatataa cgctttaatg caacaatttt ttggtatcga 34080 taacaacatt tctggtacca aggacctcat aaacacatat cgtcaactca tgaataatcc 34140 tgaagttgaa cgagctgtag caaatatcgt aaatgaagct gttgtttatg aaaagggtca 34200 caaagtagta tctcttgatt tggatgatac cgaatttagt tcatctatca aagacaaaat 34260 tttagaagag tttgatgaaa tttgcagatt gttagatgca tctcgcaaac tcgacacgtt 34320 attccgcaga tggtatattg actctcgtat attctttcat aaaataatgc ctaatcctaa 34380 agaaggcatt gttgaattgc gtaggttaga cccacgccat gttgaatatt atcgcgaaat 34440 tgtcacatct gatgttggtg gtacttcggt agtaaaaggc tatcgcgaat tttttgttta 34500 taccaccggc aatgaaggct atgcttataa cggcagactg tttgaaccaa atacccgcat 34560 taaaattccg agaagtgcca ttgtatacgc gcattcaggc cttcaggatt gttctgatcg 34620 tgggattgtc ggttatttgc ataatgcagt taagcctgca aaccaattaa aactcttaga 34680 agatgctttg gtaatatatc gtattacgcg tgctccggaa agacgtgttt tctacattga 34740 cgtaggaaat atgcctaatc gcaaagcaac tgaatacgtg aatggcatca tgcagagcct 34800 gaaaaatcgt gttgtatacg attcaaatac aggtaccgtg aaaaatcaaa aacgcaatct 34860 ttcaatgacc gaagattatt ggctgatgcg tagagacggt aaatctgtta ccgaagttac 34920 ttctcttcca ggcgcccaaa caatgggtga aatggatgat gttcgctggt tcaataaaaa 34980 gctctatgaa gctctgagaa ttcctttgtc tcgaatgcct cgtgacgacg gcggaatggt 35040 aattggtggc caagatatgg ctatcacccg cgatgaatta gatttcagaa aatttattgt 35100 tcagcttcaa cacaattttg aagaaatttt ccttgacccg ctcaaaacca atttgattta 35160 caagaaaatc atattggaaa gtgaatggga agagcaaata aataacataa aggttaattt 35220 ccatcaagat tcctattata ccgaattgaa agatattgaa actcttcgac aacgagttga 35280 cgctctttct caaatcgagc cgtatgtagg taaatatgtc tcgcatgatt atgtcatgaa 35340 aaacattttg cagatgaccg atgagcaaat tgctcaagag gaaaagcaaa tagaaaaaga 35400 ggcgaatgtc aaacgattcc aaaaccctga aaacgaggat gatttctaaa tggaaaaatt 35460 gatcgatgct atcaaatcag gtgatttgat tgaagcaaaa cgtgaattta atgcgaaaat 35520 ggctcttgtg aaagagtcag tatacgccga agaaaaacaa gccattgctc gcgcagttgt 35580 taccgaaggt gaaaaacccg aggacgacga agatgatgag aatgacgacg aagatgatga 35640 agatgaagag gatgaataaa tgcttattcc atccggctat tcagcaaatc aacaagtcgt 35700 tgaatcttat tttgcgcaag cagtgattcg agttaaatcc ttggtagaag ccggatttag 35760 caccgatgaa attatcggtg ttatttccaa aaattcactt gacgaaacag atatgtcatt 35820 ggcaatgatt gctgcagttg aaaatatttc catttcagag gcaattgtca aacacgttaa 35880 ttcgaaaggt gaagtaactc gtaccaaaga tcgagaaaca cgaaagcgca atgcatttaa 35940 aactactggg ctaactgctg ctactcgcag gcaaattgct cgtaaggcgg cgaaaactaa 36000 gcgctctcaa ccaaccattg ggataaaggc acagcgcaaa acaaaacgtg ctttgaaacg 36060 ccgtaaagca ttggggttat aagatggaag acgagctgct aattgaagta tggggacttc 36120 ccggcggcac ctgttctgaa cttgtagtcg aatcagtgga tgatggtaaa ggtgctttgt 36180 acattgaagg catctttatg caagctaacg ttaagaatag aaacgggaga atttatccta 36240 aagctgttct tgccaaagct gtcgacgact atattgctac tcaaataaat tctaaacaat 36300 cactcggcga aaccaatcat cctgcaaggc cgatgcctga ccccaatttg gcttcaatca 36360 tagtagaaaa actatggtgg gaaggcgata atgtaatggg tcgtgccagg gtaattgaag 36420 gcgattttgg tccaggtgat aaacttgccg ccaatatacg agctggttgg attccgggag 36480 tatcatcacg tggtctcgga caagttaaag gtggctttgt tcaggagggt tatcgcctta 36540 ctgtagcggt tgatgttgtt tgggggccat ctgctccgca agcgtacgtt aaaccactaa 36600 gagagagcaa agaacaagaa tctgaagctc ctacagatgc tataaataac aatgtaagca 36660 cacttaatga agcgttcagc caattggcta aaaacatggc ttcaatgttg aactaaagga 36720 aaaaccaaat gtcccttaaa gataaactgc tggctgaatc cagcgagaaa ctgggcgcgg 36780 tagccgttga actggacagt attttcgagt ctgttcagct ggacgaagcc gtaaaagaaa 36840 atgtcagtac tgcgtttgag caagctgtac gatcagctgc aatcacgctt gctgaatctc 36900 acattgccga tattgcctct tcagccgaaa ctcagctggc cgaaggaatt gaagcagccc 36960 gcgtagaagt tgaaacaaaa ctttacgaag atgctgataa atttttaact catcttggca 37020 aagaatggct gaaagaaaat gctctgcaag tgaagacaaa catcaagtct gagctgttcg 37080 aatcatttgc atccggcctc aaagaactgt tcattgaaaa taacgtctct gtaccagaag 37140 agcaagtaga tgttattgac gaactgaatg ctgagctgga tgaatctaca gctgaaatta 37200 aatcgctgtt tgacaaaaat ctggcgctgg aagagcaaat ttcttcactg aagaaagaaa 37260 aagctatttc agaagctact gcaggtttga ccgagtcaca gaaagaaaaa gttctgagtc 37320 ttgttgaagg cctggaatat ggtgatagtt attcaccaaa actgtctgcg attgtcgaaa 37380 tggttgctaa ttctggtcaa aaggagcaaa aaccgatcca ggaacaagca ttaaatattg 37440 atgaatctgc agctgcggta aacttcgaac ccgaagttat tgttgagcaa aatgataaca 37500 agcaggcaaa taattccatg gccgcctatc tggccgctgc ttcccgtatg tcttcttaat 37560 taaataaagg ttataacaat gtctctgaaa accaaagaaa ttctgaacaa atggactccg 37620 ctgctggaag gtgaaggtct gcctgaaatt gctggtaaaa ataagcaagc tcttgtagcc 37680 caaattctcg aagctcagga aaaagattcc aaaaccgatc cggtgtatcg cgatgacaaa 37740 ctgattgaag cattcggtca gtctctgatg gaagccgaag ttgctggtga tcacggttac 37800 gatcctacca atattgctgc tggtcaaagt tccggagcaa ttacaaacat cggccctgct 37860 gttatcggca tggtacgacg cgcaattcca tccctgatcg ccttcgatat cgccggtgtt 37920 cagccgatga ctggtcctac tggccaagta tttgccctgc gttctgttta cggcaaagac 37980 cctctggctt ctggtgctaa ggaagctttc cacccgatgt atgctcctga tgcttggcat 38040 tcaggtctgg ctgccaaggg tgctagcact gcagacgatg gcactccgtt tgctacgctg 38100 actgctggtc aagctgttgc taccggtgat atcgtttatc acttcttcta cgagtctggt 38160 tcagcttatc tgcagaacgt gactggcgga agcgtgactg tcggtaccaa cgaaactggt 38220 gctgctctgg atgccctggt tactgccaag attgctgctg gcgaactggc tgaaattgct 38280 gaaggtatgg ctacctctat cgccgaactt cgtcaaggat ttaacggaac caccgataac 38340 ccttggaacg aaatgagctt ccgtatcgac aagcaaaccg tcgaagcgaa atctcgtcaa 38400 ctgaaagctc aatactctat cgaactggcc caagacctgc gtgctgttca tggtatggat 38460 gctgacagcg aactgaacgg tatcttggct aacgaagtca tgctggaaat caaccgtgaa 38520 gttatcgatt ggattaacta caccgctcaa gttggtaaat ctggttggac tcaaaccgta 38580 ggttctgctg ctggtgtgtt cgacttccaa gacccgatcg atgtacgtgg tgctcgttgg 38640 gccggtgaaa gctataaagc tctgctgatc caaatcgaca aggaagctaa cgaaattgct 38700 cgtcaaactg gtcgtggtgc tggtaacttc atcatcgctt ctcgtaacgt agtttctgcc 38760 ctggctctgg ttgatactgg tatcacccca gctgctcaag gtatggcttc tggcctgaac 38820 gctgatacta ccaagggtgt gttcgctggt gttctgggtg gtcgttacaa ggtctacatt 38880 gaccaatacg cccgtcaaga ttacttcacc atgggttacc gcggtgccaa caacctggat 38940 gccggtatct actactgccc atacgttgca ctgaccccgc tgcgtggttc tgatccgaag 39000 aacttccaac cggtcatggg cttcaagact cgttacgcca tcggtgttaa cccgttcgct 39060 gaatcccgca cccaagctcc taccagtcga atcagcaatg gtatgcctgg tgctcacagc 39120 gttggtaaga atgcctactt ccgccgtgta tgggttaaag gtctgtaatt caaaaggact 39180 tggttccaca accaaggaat ggttaaggga gccttcgggc tccctttttt gcataaggaa 39240 aaatatatgc aatcaaatat tccaaaatgg tacgtcagca aaacaaggta aggctcttaa 39300 tgacgcaaaa caataacgtc atcaaattta acggctgatc gaatattagc gaatcactgg 39360 ctcatttggt gatgcagaac ctgcaaactc gttggaactc accgttaatg caggcgtaaa 39420 tattgataca ttgactgtcg tcagaatatc tgggcaggct tcgcagacaa taaactgcaa 39480 ctcattcata agtgttgata aaaacggaaa ttttgccacg aatggtggtg ctttggaatt 39540 ggtttcatca acgtcaaact tcacgattac acgagttcgt ataatcgccg aacaataaga 39600 gaaaaatatg agcagaatta acgatctgat ttctgaatca ataactaccg gggcaaatag 39660 tcagagccgt cctgctcttg tcggcttgac ccgggccgca aacaacttga tttttaccga 39720 aatggtagca attcaagaaa ctaacatgcc aacctccaca ctgtacggtg tgaaatattt 39780 gaaccctgct ggtaatcaat cattctccag cgctgcaact tacatggggt cagtcggata 39840 tcgggattcg attcctcttg cgcaactaga cactcccatg gctaaggggt atgttttcaa 39900 agattcaaat gatgtggttt acactgccac aaacccactg actttgacat cgtcaactgg 39960 aaacattgcc gatgcaatcg gtgatgctgt aatgctcggc aacctgagaa tcaagtctga 40020 agcagcatta gcagaagaat ttgaaggtgc atcatcattt gtcgaaactg atttcaagtt 40080 tgatcggtgg acagttccag ttcgcacacg caaacttaag acaaatataa gtgttgagtt 40140 gatgcaggat ttggaagcaa ataaaatgga tggtgttggc gtagtcgatg atgtcctgtc 40200 aactatgata tctgaagata ttaacaaaga cattattcag actcttataa ccgtttcgcg 40260 ccgctataag gtagaagata tttcgccaaa tgggattctg gatttaaccg ctagcactga 40320 cgccccggtt attggaagaa ctctgtatca acaagcatgc gaaatgaaaa atcagatgct 40380 gagaaacaca tcgtatgaag cgacctatgt tctctgtaca actcgcgttt ctgctatgct 40440 tgaagcatcc ggatggatgt atgcgaacga agatcctctt tcagcaggaa ctctgcgcaa 40500 cgggctgaaa gtgtatgttg atacggtatc gtcatttgac tatctgatca ctggctgtaa 40560 gcattacgtc aatgatattg aacacgtagg ttcgttgttc tattcaccat atattgaagc 40620 agatgatttg ggtgcttata aaattatcaa tgactcaaca tcactgcaac catctgttgg 40680 cattatgctt cggtatggtt tatccattaa cccgtacact acacgtatag gtcaatctgg 40740 tgaacgtaat gtaacaggtg atgattggga taacttggta ggtcaatctg atatgtcata 40800 tatgttaggt gtgaaattac ccagaatcat tccggtgtaa tctgatcaat ttacaaattg 40860 caaatacaac aaagccccga cgagtcgggg cttttctttt atcaaaacaa tttgaattta 40920 aatccttttt cgtatttcat cataaatgat gtaggatatt tcgcttcagg gctgccgaat 40980 acttcgacag tcaaaatttt gccaggatta tctttgcacc attgacgata atcgtgcgcc 41040 agttcccatc catagcgttt caacataaac aaacgaggca tgtcgctaag atagctctta 41100 gatggccaat ttcccattgg ctcaactgtt ggagcggatc caccatgttt agtattttca 41160 ttgaacaatt cgatgatttt ggcagcaaaa tcactttgat ttgtccagtt ctcggaaaat 41220 accatatact cgtcatgtac tatagcattt tcaaaacgtt taatgcaatt cattttgtat 41280 ttttctccaa ttgataaatt gctttgcgca aaagtttgac tttcatatca gcggggatat 41340 gctcttcgtg aacaaattgg tcaagatgag ccttttggct gtttgcacga gcagtgacga 41400 ttaccacgtt ttccatcgtg tatccgactt tggggtttat gcgctcaata gaacggccat 41460 ggtctttcgg gaaaacagta ccagtgtatg cacatttttc gactttcatc aattcaacaa 41520 attgttgaaa agttatacgc cactctaagc cgcgctcttc gcagcttttt actttaactt 41580 gatacggttg caagtaacgc ttatttgcgc tgaagaaagc catgtattca atttgacgag 41640 caacttcatc tcgctcagct tgaatttttt cttcaatttc ggtgctgcgt ttctctcgaa 41700 gaatttcaaa atgatgcttt ttgacaggtt caggagcttt gactgaggcc gaagcaatag 41760 cattgtagcg tttaagcata tccattctag atgacatttt aatactccgt gatttcggtt 41820 tttcattatg ggagaatttt aaccaaaatc gcggagaatg tacatcagtt tgtgttgaat 41880 ttgttcaaca aagcttcaag ctcttctctt gttggcctga cgggcatgtt ggccgaggct 41940 tgagaaatct caagcgattt ctcgggagtc aatgttgatg gcaaagtctc aaaagttttg 42000 cctttagcgc gcttccgagc tttgaagcga ccatcatttt gatgccgttt gggattcaca 42060 aagtgcttcc gatacactac cggctctcgg gtaagagctt ccagatgatt gtcgcgcatt 42120 tcatcaactt ctttgacgac atcgatgaca tttgtcgcgc gaatgtcata cattttggcg 42180 atttgtacga atccatgctt catttcacga aacatgaaat gcacttgtac cttttcggct 42240 gacgaaagct cagaaatatt acgcattttc ttcttccttt tgctcttgaa tccaaatatt 42300 cagtttggca taagcgactt ggtatttcaa ggtacgttct tgatctttga ctgtaatacc 42360 tttcagtcgg cgcagatcag aattgtgtct aagatcaaag cacttcactt tcgcggatct 42420 gacgtccaat ttgattcgat caagatattc ctcatatttt tcaccatcac gcttcgtcag 42480 attatccacg agttgacgca tttcggtgcc aaaagtgatc tcgatcaaat ccagtgtctc 42540 tgcaacaccc agcgaactat cctctgcaca atcatgaagc atgcacagaa tttgaacatc 42600 aacgtcttca ttggcatgtc tggcccaatg cagcaatttc aatgggtgca aaatatacgg 42660 atttccgcct ttgtcaaatt gatcaatgtg aacgcccaca gcaaagctaa tggcatctgc 42720 gagatccttt tgagtatatc tcattacgaa tacctcatag tgacttgaat tggccgcgaa 42780 cgcatcgact ctgggagtcg ggcaccctct tcgattttga gagtgtcatt tccgttttca 42840 tcggttcgat cttctaccgg acaaatagaa tcaacgtaag ctttgatgcc ttcgataatt 42900 tcttcttttg tctttggcac tatcgcaccg ctgatgatat ggtccggacg gtttgttttg 42960 aaattgaagt aagttgtcgt gaatttcatc tttctagtcg ctcaatttac caaatggaat 43020 ctgttcaaca aaagcccagg cagcatggta aaccgtcgcg cccggcgttt cagacataaa 43080 gaccgtgtca accggtgcaa taactcgaaa tagagttggc tcgccgccaa tagaacgagc 43140 agcacgtcta gcataaacct tggctagacc gcggtctttg gtgaaaaaca cacggtccaa 43200 gttctttttc cggccctttt cggaaatcgt gtctgttgct tcaggcggaa gaagcatatc 43260 acctttaagg ccgagtgtac aagagccatg ataaaactcg acatagtcgt ctttgcagtg 43320 gattgttctc atgatatgct ccttggtaga tttgatggga ctatcataac acatagccca 43380 tcattgtaca actatttcat gaattgttga cgctggtttt tgatcagccg atctttgatt 43440 ttttctgtaa gcagacgaac tcgatgcatt ttgcccgggt cagtgacgta tccatgttca 43500 aaaatcacga tctttgaata tttgtcgtta tgttgtgtct cagaaaaagt aatcggtaat 43560 gctgaagcat aaacaaatga atcgactgag gcattgagca aaattccgcc agatgagatt 43620 atggaaattg cagctcgatc gtattcgctt tttgcgattt ttacaaattt ttcgatgtcg 43680 aattctcgat catcagcaaa tcgagaatac atcaaacata aaatagcttt agtgtaccac 43740 tgtgctttgt tgtaatcgat accgtcatct ggatagtcac gcagttttgc aagatgtgca 43800 agagccattt tctttttgaa ttcacgtctg agttcaagca gagtatcaat aacgtcacgt 43860 agattatggc cattgaggtt gaaatcgcca aaatggtcac gtaaaatcat cggatacatc 43920 agggaatacg acgattccca tatcgggccg tcaattgcaa ctggataagt cgttgcagtg 43980 tacatcaaat cacgaaattg gatttgaaac cgtgcaccac gattcttgac tctgtgatga 44040 attggcgaat ttgggtcagt gaacattttc ttggcatcag cgacaagcac tttgccttcg 44100 atggcttgac tattttccaa aatcgtattt tccaacgctg atttcagcat aatttcctca 44160 ctttcgatta ggaagattcc ttaattattc ggaaccttgt gaattgccca aagttggcaa 44220 agccatcata atacgttttt ctagaaatgt aaacaaaaaa aaggagcccg aaggctcctt 44280 tttacttggt ataagcagat gctttgtaaa tgtacccgtt acgggattct tgcatcaagc 44340 attcgccgta ttcctccgcc gcttggtcaa tcgagaaagt aatgattggc caaggacttt 44400 ctgcaggtgt ttgacgccat gttggattcg ctaccatcca gtcgtgtacc cagtacggaa 44460 cccacgagaa actcgagttt ttgaaagcca aggggtgaac gaaccaatgc tttccgtcaa 44520 gctcgggtac ttctacaaca gtcacagcac tctcggcagc gagaacaact ggcacagcac 44580 catcgtcagc aacaagagca tatgtcacat tgcattttac agtaaatgaa ccggccgaat 44640 caaaggtttt gctaaaagta gttgatgttt ctccgctttg aacaacgtcg tcaacaagcc 44700 attcgtaacc aacaacttcc tttaccgtct catccccgct aaaagtaacg gtaaagtcaa 44760 cattgctacc ttccgaaacg gatggatcaa gaggagagat agaagcagta attgccatat 44820 tgttttttcc ttaaacaaaa gaaggggtca ttgaccccgt ttatgaaata acaataaatt 44880 tgctatttcg tgattcgcga atggcaacag aaccatctcg ctcaatgtaa aatgccaatg 44940 acttcaacag ctctttgtca tatgggcatt ctgcaatttc aattttccaa tttcttcctt 45000 gcatccaatc gtgtatccaa tacggaacat taataaatgc tcgaccttct ggtccgacca 45060 gtcgatattt tggcgcatag tcttcaggga atgacaaaac aaaatcagaa accggttttt 45120 cttctacttg agtagttgtc tcagttgctg taggggcttc aattttcaac tcagaaaatg 45180 gaatggccgg tttttcttct acttggtctt gatcgacaat ttcaatcgat ggctcagcaa 45240 caacaggctg ctctgttgtt tcaggcgttt catcttcaat atccatttta tcggggtcaa 45300 gttcaatccc ctttgatagg tcaactcgtt ctcccatatc gatagtttct ttagcatctc 45360 cagcttccgc acgggcagcc tcgaatttag cattaacttc agattcaaaa tcgttcatca 45420 tattttcgaa cgatttgttt ctggcgagtt taatgtcgta attcttgaga gcataatccg 45480 ctagtttttt cttgccttct gcagcagaaa gagaaccaaa ctgagattcg atatcagagc 45540 gactaaaaag tttctgtttc atggtgattc ctttgtataa ataaaactat atgacttatt 45600 taagagacgt ttaatgataa atattgtatt tgaaaactac agttttgcca aggttgtttg 45660 tgaagactcg atcttctatg aaatgcggga gtatttttca tttaaagcag atggctatca 45720 attttctccg cgtttcaagt gtggaggttg gtctggtgac atattcctac taggatatga 45780 tcatttgctt ccttatggac tagtcactca agcaataaag tttgccgagc agaacgatta 45840 taaaatagtt gttgatccgt tgatcacgga aagacaaaat atttcacgtt ctgaatttga 45900 tgcatgggta aacagcaaag atatttattc cggtaacaac aaaatcactc ctcactggta 45960 tcaggctgat gctgtgtatg aggggatatg cacaaaaaga aaattgctaa atttgcctac 46020 atctgctggt aaatcactga ttcaagcatt gctgtctctg tggtatttgg aaaattacaa 46080 aggcaaagtg cttgtcatag ttccaacgac atctcttgtc aaccaaatga ttgatgactt 46140 tgtcgattac cgtcttttcc ctcgagaagt tatgttaggg ataaaaagtg ggaccgtaaa 46200 agattcgaat gctttgatat atgtttctac ttggcaatcc gccattaagc agaaaaaaga 46260 atggtttgac caattcggtt gcgttatgaa cgacgagtgc catctatcaa ctgggacatc 46320 gataaagaaa atcatcgaat ccgtcgatca tataccgttt aaatacggtt tgtccggctc 46380 tctgcgagat ggtaaagcaa acattttgca atacgttggc atgtttgggg atatatttag 46440 accagtaaca acaaaacagc tcatggaaga gggccaagta tgtgatttgc aagttaaagc 46500 aattcaactc ggttattcga acgaagatcg aacttctgcc agaaaatttt cttatgatga 46560 agaaataaaa tttatcacga atcatacgaa aagaaataaa gttgtatgtt cgatggctaa 46620 aaaaatcgca gacaaaaatg aaaatgcatt tgtgatgttt cgtctgaaag cgcatggtac 46680 ggctttgtac aacacgctta gaaagattca tgacccaggt aaagtgcatt ttatatctgg 46740 agatacagac actgaaatcc gcgatcaaat gaaagtcatc gccgaaggtg gaactggtca 46800 tgttttcgta gcttcttatg gggttttctc aacgggcgta tcaatcaaaa atttgcatca 46860 tatcattttt gcgcaccctg ttaaatcaaa ggtaactgtt ctccaaacta ttgggcgagt 46920 tttgagaaag cactcatcca agagtattgc tacagtatgg gacattattg acgatattgg 46980 gataatcaat gctcatggga aatacacaaa gaaaaattac gccctgacgc acgcaataga 47040 acgtattgaa agatatgtgt cagaaaaatt caattacact ttgcacaaga tttctttata 47100 ggaggatgca atgggaatgt ttcagcaatt tatagcagaa gcaacagtgg attcatttat 47160 gtctaaaatt gccgcatgtc aaacagcaga aggactagat gagctggaaa aatattacaa 47220 caagcgagtt aaagaagttg aattaaaacc cactgatgat atttcggttc gcgacgctat 47280 cgcaggtcgt agaagcgaat tcgaaaatgc taaagaagat agtgaaccgc ctgaagactt 47340 ttaatacaac aaagggactg caatgcagtc cctttttagt tataccagaa gttcagtttc 47400 ttcaagaatt ccagtggatt ccgaaagagg caaattttca gcgtaatgcg cgcaaggtcc 47460 aggatgagta agtccataac cggttttaac tgccagcgct ttagcaaccg gttgtttaca 47520 tactacgcaa atttcatcgt tcattttatt ctccaattac gtccaaagcg atagggatgt 47580 atacttcgat ctgttttttc aacgaagcag cgtcagggat agaccatttt ccatctttca 47640 caccggctga cagctgtgcc atgagttttc cggtgataag attgatattt gggccatgca 47700 cccggtaaag gtctagcaca gctttaccat tgacgaccga gttatattgt tcgtcagtaa 47760 tggcttgagg aataaactgg gaaagaagtg cttcttctcg atatgcgttg gcaaggtcat 47820 attgattgta tttttgagca atacgctcgc gaattccctt caaaagggaa ttgattactt 47880 tgataactgc agcgtcggaa ttatctcgag tttgctggac ctggccgatt actagaccga 47940 gaagatttgc agctttagcg ccatcagagc caagcttacg aaaagacata cggacttctt 48000 caattttatc gatgatcatg ttttactctc ctttagtgtt gaggctagta taacaccata 48060 aatcgatagt tgaacagtaa aatctggctt ccaggttttg gccttgccaa aacttatcct 48120 ttatggctta atagatatta taactaaaag gataaaaatt aacgagcaag ctcgttggag 48180 ccatgggctc cagtattgat ttttacattc catttcctgg agtatcttat tcttttcagc 48240 aattcaactg actttttatt tatgctgttt tccaggtgac ttttttcttg taatttgata 48300 caaaaaaagc cctccgaaga gggctaaatt aattcgaaag cttcattttt atttcgtcta 48360 tcactgctgg attatcgata atcgaaaatc gaattgtaac aattagttcg ttattatcgt 48420 aatttccggt tgagtcgact tgaaggttgt atacgcgtgg ctcaaagttt cgtatagccg 48480 tttgaatatt tcgtctaacc gtgtctatca ccaacggtgt gatgttttca aatagctggt 48540 ctggtaagtc gcaaccaaag tatgggttaa atggtctcgc gccaatggga gtagaaacta 48600 tcccgataat agaatttttt acagcacgag ctcctcttgt cattgacgca tcattgtccc 48660 atgatttgtt taaatctggg tcaagatctg tataaagcag gtttatgttc attttacccc 48720 cagtgaatcc aataatttac tagcaccatt tataaccgct gggtattgat ttccgcattc 48780 gcattcaatt ggaactgcag catatacctg tggagattga agtttttcta cgatagcttc 48840 aatatctgaa aacgtcaaat gcttaaataa aatgtctttt tcgttttctg ttgaattttc 48900 ccacttgaat agctgatctg catattcaaa tgacacgata catctgtcta tcatctcaaa 48960 catatcccga tcttcaaaca tcatcgggta tctcatattg ataaccattc cgccagcgac 49020 gtgtgatagc cccaatccgt cagaaacaca gacattgtcg ggatgcactt caaacttatt 49080 ttctttatga cataacgtac actctgattt cattttgatg acttttttct ttgagatcgc 49140 tatcaatttg atgagagctt gctcagttag atgtttcggt aacggccgac ctattttatt 49200 gaaaatgatt ttcggaatca tttcatctgc gtcatttacg atagacagat attcgcgcac 49260 cgacaacata gtagtttcta cttgcttatt tccaactgtg attttaatgt ccatacagtc 49320 ctcctgaatg tatttaaata acctaaaagg agtgtatcta ttatgaatat aatccgcata 49380 aagcttccaa gcggtacgca cagattcaaa ccgataacag tttcagaata tcgtgattta 49440 ttattgatca gaaatgagat gagaagtaaa cctttggaga aatctgagat attttccgat 49500 ttgctcgaag aaatgtttcc ggattatacg ccgtttgaac gtgaacatat ttttctgata 49560 gttttttctg ggagtttggg caaatcactt gtagatgcaa ctttcacatg cccgcactgc 49620 aagtcgatgc acaatcttag attgaagttg acacaagagc cactaaaaac accagagttg 49680 caggtaaaca atataacgtt caaatttcgt atgcctcgta aatcaggttc acctgacgag 49740 ctcttctacg agactgttga taggatatat gacggacaca acgaatacac ctgggatgaa 49800 ctgggtgaag atgagcgcag tcaattggtt gatatgattt catacgaaga atttgttgaa 49860 ctatcaaaat cattcaaccc gattttagta aatcaaaaaa tcagatgttg taaagattat 49920 gacatcaatt ttactaatat gctcgatttg tttgaggttt tggttaatcc tgatgaaatt 49980 tttaattttt acaagataaa cagagcgcta gtaagacatg actattctct ggccgacata 50040 atgaatatgc taccagttga aaggtccatt gttctcagcc tggtggaaaa agaattaaag 50100 gagaaaaatt aatgttacaa cgcgctggtt atcccaatgt ctccataaaa ctttaccaga 50160 actatgatgc ctggatggag aataggttta ttgaattggc agcaactttt attaccatga 50220 ccatgagaga tggcctaact aatggtataa atgaagggct gctgcaaatt tatgactcaa 50280 acggtttaca gacacgtttg actggtgatg aaataatcca aacatctctc aaaacagcga 50340 acactgaaat aacttataac cggttgtatg gcatcaaaca tctttctgca aacgtagata 50400 tgaaaggtga caacatcata acattccagt tgggttcatt acattcggta cgtaatctca 50460 agtttagcag aatgtttaca aatgatgctg tagcatccgt gaacgagatg attgattatt 50520 tgtattctgg aactcccaaa ctcgcgccga caatcaattc gattggcact agagtgccaa 50580 tgacaaattg ggtgttggac ataaatgcat actacaagtt tgttagacga catggccaaa 50640 cgactggata cgaaagtgtt ccattggttt gggaagatat gttaggcatt cacatgtcag 50700 attttgaatc tatcagcaaa aatgatccga tacaatactt cgtgacggag ccgcgtttgt 50760 ttggtgaaac tattgcgatg gtagataaaa aaatatgctt tgattttgaa tggttgacaa 50820 aagcaaacgc gtatactcgt aacccatacg agaatacctc gttttatgcc cactcgttca 50880 tagacaaaat gcaaactcgg gttgttactg gcgaagggct aaattcagtt tgtattagtc 50940 gttctggcgc atattacgac caaataagcc ggcccggtgc cgaagagtac aataggtctc 51000 ttatattttc agaatatgac gcatattgca cagcaaaaac atatggagaa tttggtctcg 51060 tgccaggcat gcgtttggaa ttctacgatc aaaagaatca atttagaggc gagtatttcg 51120 ttgatgaagt tatacatgaa ataagcagag agcaatctat aacaaatatg tatcttttca 51180 acaactcgaa agctcataca gattttaacg aaaggcaaat aacatgaaac caaaattgaa 51240 cattatccct gctgttaaga acataaaagt caatggaaaa gagatcacaa ttccaaaact 51300 tggtttcagg catatcaaat tgctgaaaga tatgcagggc gtagactcgt gtatgatcga 51360 attgcttgat tctattcgcc cgggtttgac tgccgctgaa gcagatatgg taattttgca 51420 tctgctggca ttcaacaaaa agttgccgac cgttcaaacc attaacggtt ttgacgttga 51480 tattgacaaa gcttatatta gcgcaaaata tgaattcgag ctaaacggca atattctgta 51540 tttcaaacct cccatgataa ctgatacatt tgtatcgaaa ttggacatac tgaccaagca 51600 atacgacaaa gaaaaaagcg ggtttgactt taatttcgaa gatgcgcctg cgtttgtatt 51660 ggattgggca gattttatag tttctactat ttcacttgat acaccattcg gtaaaataaa 51720 tggtggctca aacattattg gaataatcta atggctactc aaaagacact aagagacttg 51780 agaagagata gacaaagaga ttctgaacaa tctaaaatca aaactgcttt ggaaaatccg 51840 ccagacaaca ctggcgatct tttagctgca tctgagctta tatccgaaac agttgaacaa 51900 ggtaattcag aacttcgtaa aatagttaac aacacttctg aaaccgaaaa tattgctgct 51960 gcaacagaac tttcagcgga agccactgaa atttctaatc agcacttgaa agagatttcg 52020 gatacttcca agaaaacatt tagcaaacta agtgaatttg ccgaaaagct aaaaaataat 52080 ttcttagcgg atgttgaaaa aaatccaatt acgacaacaa acactagtga ccaaacagct 52140 aaaaagatat cagaggaaga agaacaaaca cccaaaaata acccggtttt ggggtatttg 52200 aaaactattt ctgaagatat caaattcctg aaaaacgata agccaaagga agaagaaaaa 52260 gaggataaag ttaaaccaga caaagaagaa aatgttgaac gtgcgattga ccgaatcgga 52320 gatcgtattg tgtcgtcagt cgataatggt tttaagaaaa ctattagcgt tgccgattca 52380 ataagttcaa tgttgttcaa atacactttg actgccgttc tcaattttgc caaaatggct 52440 gcactcgttc tttccttgat tatgacattt gacgttttat ctcgtcattt tacccattgg 52500 actaaaatgt ttgaagagaa ttacgccgaa tttaaaaatc aattgggctc tttagcaaca 52560 ccatttgaaa atgttcatgg agttataaca gacctgatga attatttcaa gagtgatgaa 52620 tatacaaaaa tgtttgttcg tcttgccgaa ggtgcctttg accaaatgaa atatatggtc 52680 aatatgatga tggtcggttt ggccaaactc ggcgcaacta tattaagagc tctcggcgca 52740 gatgaaaaag ctgattcgct cgaagcttct gcaatatcag ttgctgcatc agaagtcggg 52800 tatactcctt caaaagaaga ggaagaagta atcggtcgtg ttagaaaacg cgaagctgaa 52860 gatgcaaata acactgaagc taattggttt gaaaagcaat ggcgtaaagt gaatggggaa 52920 gatgaagaga cccctgatga gaaagaaaag cgtgaaaaac gcatggaaat tgccaaaaat 52980 actacggcag agcaatttgg cagatatgac gttctgagcg ggaaaataaa ccacgttggc 53040 gttactgcta aaaagaatga aacttctcct gaattattga acaaacaccg tgagttgctc 53100 gatgatcgct cgaatgaagt tgaacagtct tatcaagaag gtaagttgac taaggaatct 53160 tacgaacagc ttcgagtgga aatagacaaa cagactaaat tcttggcaga gcatgagaaa 53220 acattggttg tgccgacagc tgcaataaaa cctgctcctg aaccagaggt ttcgactgtt 53280 aaatctatcg acaaagaaga gaaaagagtt gaaagcaaga agcaagaggc agctagtcaa 53340 accaactatc acacaaaggc taacattgtc aaaaatcaaa atcaaacaat tgtccaggct 53400 ccaagaacat cttcgcctgg gcctggtata ggaaataaca tcttatgaga gtaaccgaac 53460 ttttagacgg cggggttcag gatgtggtag gcgggatatt gaaaggagag aacccggcaa 53520 cgggttcttc acctcgcagg cctattagca aaattgccat agcccaattc cctgccgaga 53580 gaaattcagc gaatgactct gcgcaagatt tcaatgttaa tgatctgtat aaaaacggtt 53640 tgatactgtc agcatttaac tatgccggca gacagactgg agatttgcga tcgttcagat 53700 caggtcaaaa taacattggc gattatcgta agggtgttgt caaggaagcc atagctaaca 53760 tcctgatgcc tcggggacag actgatgtag atactattag ccacaaattc aatgatgtcc 53820 agcaatcact ggttgaacga ggcgacagtt ctgtaaccgg agcattgagc tcgatggctt 53880 ctcatgctct gtatggagga ttggagtcta ttacccaagg agcatttgct gaccgaggcg 53940 aacaagtata tatcgcatcc agagcaatgt atgctggggc agagaatcgt acaaaaacat 54000 atacttggca attgacacca cgtaatgtat acgatctgat gcaaattttg acaatttatg 54060 agatgctttc gtattattcg tacggtgcag tcgaaaagtc aaaaactgcg agtcaaataa 54120 aaagcactct tgacaacgca tacaaagaaa cattcattaa cccactcaca ccagaagcaa 54180 ctcatgggca aactacgatg tttgaaagaa taacatcgtt tttgagtaat gtcaacgttg 54240 tctctaatcc aattatttgg actattagaa attttggtga gacgagttcg tttgatatgc 54300 gatctgatat gtttggtccg gcacaaatac aaagcatacg atttgacaag agccctgatg 54360 gtcactttgg tggtttagcc atagcaccta atttgccttc aagttttgta cttgaagtca 54420 cgttcagaga gattcttgct cttaatcgat ctgatctata tgatgaggaa taatcatgta 54480 taagctggat gaatttcaac aagaattgaa taaagacttt cagagaacga atatgttctc 54540 tgttgttttt gcaacaactc cgtcatctaa aacaaccgat ttacttgacg gatttggtgc 54600 gtacctctac aacaatcttc cgttcgggaa agattttgcc gggctgacgc agggtatgct 54660 ttcaagtacc ttgaataaag ttatagttca aggtacgcaa aatatcatac gcaaatcagg 54720 tgtttcaaaa tatttgattg gtgcaatgac atctcgaact atacagtccc tacttggtca 54780 atttgaagtt ggtacgtatt tgcttgactt tttcaatgcg ggtaatacac atactggttt 54840 aactgtttat tctgtaaaaa tgccagaaaa ccgcttgaat tatgaaatgg ataaatttca 54900 caatgctcca aacatcaaac taatgggacg cgagtatgat cctctcataa ttagtttcag 54960 aatggaccat caagcggcca attaccgggc catgcaggat tgggtaaatg cagtcgaaga 55020 tcctgtcacc gggctgcgtt cactacctgc tgatgttgaa gcagatatac aagtgaattt 55080 gcacgctcga gacggtatac cacacactgt gacaatgttc aacggatgta tacccgtcag 55140 cgtatcagcg cctgaactta gctacgagga taacaacgct attacaacgt ttgacgttac 55200 attcgcgtat cgagtgatga ataccggtgc ggttaatcaa gcaatgcttg aagactggct 55260 taagggtgat ttattacctg aactcggcaa acaagctggt ggatggttgt caaaatttgg 55320 ttcatttgga taacaaaaag ggagccatac ggctcccttt tttattctat cacctggaca 55380 aatttgcttt ctccgcctaa atcgatgaga gttgacaaat aattgtctct ttgtatcttt 55440 tcagctttga gtctttcttt ttcttcgtct tcacgagatt tcatgaatcc agaaaaacct 55500 tcaatcagtt tgacttcacc tgtttgcatt agcaaatcgc cgtcgtaaat ctctgttgat 55560 tcgtcgattt ggcttttgaa aacggcagaa caatctatca gatatttcct ttttccatca 55620 gcaaattcac caacattgct gacttttttg aattcgaaaa ttgttcctcg tggaagaaca 55680 atttcgcgtt ctttcgtata attcgacatc ccgttaacta taagagctgg gacctggaca 55740 tttttgatag caaatgcgaa atgagccccg tgtttttcgg ctgtttcaac ctgcgcgtca 55800 tcattctctt tagcattaag aatgtcaatg tcatgctcgg caatagaccc acctaaaaat 55860 acaataggaa cagcagaaca tgacacgtag ttagaaaaat aaaacatttt attttccaaa 55920 gctactttag ctggatattt tgagcatgac ataccccgcc aaagagtgag attctcggga 55980 agtttaatgc ctgcaatgtc aaaagctctg tcgagattct gtatatcatt tacggtttta 56040 gctgatggtt ttatgttggc gatgaaaaca ttgttaatct tccgatagtc attcgaagtg 56100 taagtttgta tagcatcaac acattcaggc ggcaatcttt ttctcatatt aacactgccg 56160 acagtatcat caaatttgtt accaagataa ttcgcccatt ccataatagc gcgtctcacc 56220 tccttataaa ccatgaaatc gacttttcct ttcttcacac ccggatgttc atccggaata 56280 ttttcatcta cccatttctg tgcggctttc tctgacgttt gacgaactgt ctccgcatag 56340 agagcaagca attcatggct tgacgcatca tatttgtcaa agtcaatttt gtcaagagaa 56400 ttagcagcgg ctaaattaga gaatttgtaa taatgcgatt tctgtatttg ttctttggtt 56460 atcgtgttat aagcattgat aactgcttcc tcagcctcgc tagttggcgg ttttttctcg 56520 actgggccaa caccaaattg gtcgtagtaa ttgttttcct tgtccgaaga ggcaatactg 56580 gttgtgaatg ccttgatcaa atcttcacgt ggaattctga agtttgtcat tgacttagta 56640 gagcgttttt cttctctctt ttcaattgac ctagcaatag cttctgcctt tgtaactttt 56700 tcaccagttt tcacatcaat gacgacatcg cctacactgg tagatgaaac cgtataaagc 56760 tcaggatcaa tttccaatcc tttgacactc gtgattcctg ttgattttcg gtaaatcata 56820 atgtatgtat actttttgcc tctttccagc aattctggca aaacaataaa ctttccacct 56880 gatcgttttt gcaaaagccg ggatgtaatt cgcgcaatat ttttagcttg gcctttcagt 56940 gcctttgtcg gaaacatcag aagcgttgca tccattctat acctgacaag catattaacg 57000 atttcgtcag ttatcatatt cattgcgcca atggggtcac taccgagacc atctctcaga 57060 atctgtggtg ttcctttttc tgaaatctgg atgacctgcg tttgcatgaa tttgtcgcca 57120 ggtttgacct gcttcgcgga atcacccttt gaagtaaaat tacagaatcg caaagccaga 57180 ttttctgaac caggaacttg gatgtttaat acatacggaa cttttgtttt tggcaaaaga 57240 ttgaccacac ggtattttcc aaccccgccg tcgaatacct cgtccaattg ctcatctgtc 57300 atctcaaata acatcatttt attttcctta taagtctaaa atgttattta cactactaat 57360 gttgttccag tgaattgact caatggaacc gctttcgctt taacaaaaca aaaactgtcg 57420 acgtgagaca catattcgaa aatctcatct attacgagta cagtgttttt gtccaaaatt 57480 acttcgcact cctccgggta gggactaagg tttcccggaa tcaggtgttt cacattatga 57540 cagtcaatgt gcatgtttat agtgacaggt cgatgtgggt cgccatcgat aacaatttcg 57600 cgtgtgattt cgttaaaatc gagatgtctg cattgcgcaa tgccgtaatt gaaaaaaagc 57660 gggcaaaatg atgtcgatac gaaattttta aagagaatag acccactatc tttaaatttc 57720 atataatctg ccttattgag agacattcct ctccatacag atttattaaa attctcagat 57780 tctgccatat gtgaatccat ccgtcgtatg cactcggtta cgaatttttt atttgcatcg 57840 tcgaatattc cagaccgcaa agcagcagaa acgtttgaaa attcttcatc gcaatagcta 57900 gacacgtagt cgtcatattt tttcaaaata cacatgcaac tgtcagtgta tcgttgctcg 57960 gctatacgat tgcacattct tattatatct ggggagtttt taccatgaaa gtcaaaaatt 58020 agccgcactt gctcatatga ccccaattcc aaattcatcc atggcatgtt tctatggctg 58080 ctaacatcat gagcgtattc tacgttttta catgcccact ctaattcttc aaaagttatt 58140 ggggaattta ttgtgtccgc ggtatatccg ccgaatgacg gatgtgattt taaaaatatg 58200 ggcttttcaa tagctacagg tacaacagtt gaagggttta gcataatttt ctccaataag 58260 ctcccgaagg agcttattca catactttta caaagaatgg gaattcgaag tcgtctgccc 58320 gaacagccat gaggttaacg cgggtcatac ggataacttt cattgcacga atatcaccgc 58380 cgccaaaacg gctatcgttt ggaacagtgg cataaaacgt gttttcgggt ttttgaggaa 58440 gctgtgacag cataacttca gttgctttct caaaagcagt ttgagcgtcg tcggcttcgc 58500 cagtgtgttc ttcaaaattg tatcgaactt taacaatcat gtgaatttct ccaatagttg 58560 tgtacgtatt catactatca aagccgaatc aacatgtaca caacaaaaac gaaaaaaagg 58620 cccgaaggcc tttttcagtc cagaatagca tctgggaaaa catcatggat gtgatttggt 58680 tttgatttgt cgcgtcggat gagttggaaa ataggaagaa acaacttgaa ttttgcttca 58740 tttggcttgc ggcccttcct ctcttgcaat ccattgcatt tgcattggac aatctggcct 58800 atcaactcat tttttatcag cataagtgcc tggcggtcat attcgtgtct ttcactaatg 58860 ggaatttcga ctttagcacc gtttaccttt ttatgggttg tgtcttttaa gccggaaccg 58920 catcgaaccc tgatttgacc tgaagaatct tccagaacaa aaccacctac ttttgataca 58980 tcttttcggt gaggataaac ttcgacaatc ttcaaatcaa tttctacttc taccttgaat 59040 ttgatttggt cagttgttct cgcgtttgcc cacagcccat ctttattttt aagaatgata 59100 ccttcccggt cttgatcgac atatctctga taaattttta tagcttgttc atatgtctca 59160 acttcttcgg attcaatgag ttgaatgttt tgatattttt gggtaccatc gaaagcttca 59220 gtcaaacaag caagagtagc aaatcgattc tcgtagtaca atttgctctt ttcgcgctcg 59280 taataaactt cctgtggaat aatatcccat acgttaaaaa tcatttctga ttgttcaacg 59340 tcgctaattg ttccatttag agctttatta cttaaaccat tggacttgtt tcgatctgat 59400 tcgatttctt cttcatttgt ctcagaaatt ccaaacagat catccagtgt atgttgttta 59460 gccgttttaa tggatgcaga gaatggagct cggtgaatca gttcaccgtc tataacaaaa 59520 tcaccataat ggggcagagt ctctctgaca acatgggcga gttccttcaa ctgtgatgta 59580 atgtcatata acttcagata ttcgttacca ttccgtgaca ccagtgatac ctgtgagcca 59640 tccgcagata cgagagccat acaacgggca ccatcggctt tcaattgagc aatagcaggc 59700 caacggattt tcttcaaatt cttttcactg tatggtgccg caagaaactg aggttgctca 59760 ggaataatgc caggccatgt tttgtttcca agagcaacag atgctccaca gttgaggtcc 59820 cttgaaagaa tacgtctggc aacttcacaa ctagaacttg tcatactgtc aagcatctgt 59880 tgcatgtagt gaatacctgc attacctgtc aaatttcggg tggaatattt tttgacaagc 59940 tcgtcgcaga aattttccaa actcataggt ccaactgaac cgccgaaatt caaacctttt 60000 ggtgtaatgc cgtatgttaa ctggcggtta tacgcgaggg tgaaaacggt tttaagaagt 60060 ttattttctt tgttgcgatt caggattttt tctttttctt ttgacgaatc agttgaggaa 60120 atttcgttca gaatgtctaa aatatgcatt tcattttacc tcagagatgg taggtttatc 60180 ttgccaagtt gaatgatgtg acaaatcgat tgtatttggt tttgggtcaa gttgaactaa 60240 tagcttttca atatcgtacc aatttttagc cgtgtgatat ttgttgatat catgttttac 60300 ttcacgagcg ccgtcagttc gaagcatatg aatttgaggc aattgcgaca ttgcatcatg 60360 acaatcttgg agattactta ccaaatcatc aacaaaacaa accaaacgat ttttatattt 60420 ttgttttacg gaaatgtagt gcggcatttt ggtttcgccg atgtcaacac acagaatgtc 60480 tttgaacgca cctgggaaaa gtgtgttcag attgcagcac cggtttagca gagcttggtt 60540 agaatcaccc aatgcagtaa tggcaataaa gtcatattga tctttcagcc gatttacaac 60600 atcaattgca tcgacatatc cagcaagata tttgatgaaa tctgagttgt tatactcacg 60660 catcaaaatg tttgcaattc gcgcgttgac gccgaacaat tcttcaccag tgcggaatcg 60720 ttcgtcgacc agagttttca aaatttcgtc ggtccgaatg ccatttttct gcgcgaaata 60780 cgggagacca gatgtccatt gaaccaaaac tccgtcgaca tcagtcaaaa taatcggttt 60840 ttcgtgttgc attatatttc cttttcaaac cacttttgaa ataaaaatgg gacccgaagg 60900 tcccaataat cacttttgac gcttgcgacc ttcgtgctta ggctgaccaa acttatcaat 60960 atgtttgact tggcgcataa cacgagctac cagtgcatcg ccagtttgat caatacgact 61020 gttggattta cgcttgtaac cttgacggcc ggttttcgga gattctactt ttttctcaac 61080 tgctttcttt tgcttagcca ttttcatttc cttttgttta atttgtttaa tcttacactg 61140 acaatcaatt aagcatacac aacttgaata tctttccagt gacatgctga cagctttcga 61200 ctattctttg cactgatttc accggacaga tatcgaggat cgggtacatt gtgcatacgg 61260 ccatttggaa tcaaaacttg catacctact ttcaaatggt ccggtacgtc tttaccgact 61320 gaaataatct cagcagtgag aggaacttca ggaagatcgc gttttcccag aacaaatcca 61380 gactctgaaa tgatttcatc acctgcagat gccaaatttt ttgattcaag aataatgctt 61440 tcaaattgag caataggtgt tacgttagtc atgattttct ctttaactgt ttttgttgat 61500 gggataatta taagttatcc catcgtattg caaacttcag cacaaattaa aaactggatt 61560 cgtcttctac aaggaaccac gtgttggtac cgtgtttgtc ggacaaaagc tcaaatcgcg 61620 aagagttttc gaccatatcg cttaactcat tggggtcgac ggatttaaaa ttcacataac 61680 ccttgctttc ggtagaaaca taacgctctt cgatgtgacc catttccagt tgattgcgat 61740 ggtacgcacc gataagggac gccaacgtgg ccataccagt accattgata gatacgagcc 61800 gatcaactcg gaacgaccgc caggcttttg cttccaggtc gtaaacaacg atgttcagaa 61860 tattagtttc tttgcgctct ttcttttctt caggctctgc tgccataaaa gctttgtcac 61920 ctttttcggc aacctcgatc aggacagagt cacgagtagc aagcattacc cgatgcgaat 61980 cgtctgcttt tcgaaaaatc agttcatgtt cgccgtcagc caaaatagag aacagcattt 62040 gttgaagtac atattgctta gacattttat ttccttacag agtgtttggt tggttcagat 62100 aattcgccat ttcacggcga atgattgccg gcatattttg tttacaagca gcaacaatcc 62160 gggattcgat ttccataaaa gcttgctctt tagctttttg aattcggcgt tcggcttctt 62220 gaatgtaatg ctcaacgaaa cgcttaccag cttcttcacg tttaccgagc tctgcactaa 62280 ccatttcatt ggcccatact tccataccct tcatcaactt caggtcttgc tgaatggcat 62340 agttatggat agcacgagcc aaactggaat tggtcttcaa ttgtgcgctt gatgcatccc 62400 aaccgttgtt ggtgatcgtt ttgttcagca tgtcacgaac gatggaatat gaatccatag 62460 aaacaccagc ctcttgaaca gctgtacgaa tctgatcacg tgctacatca ccaagatgct 62520 tttcttgcat tttctttgcg aagttggcaa taacagcatt ttgcagttct acacgagcct 62580 ccgaaccttc agggaaaagt gattcgagtg ctttagtatc gagttgaatt ttcattgaat 62640 tacctcataa cgagaattgc gagtgaaaac gatagtacgt tcttcgaact caccgcgagt 62700 gtggattacc atatctacag tagaagtacg aatcacttta ccatcagcaa aatccggatg 62760 accggtaaca aagccgataa gacgtggata ataaccaagc aacggctcgt ttttgtcaac 62820 tttgatgacg gctttgacat cgtcaaacca ttcgggatcg attcccagaa cggcagcttc 62880 tgcaacacta ttaacttcaa agaatttgac ttcaagtgct ttggcgttag gagatacttc 62940 aacgatcata ataaattcct caattttggt tgcttgtggt gtaaattttc ttgataatgt 63000 tgagaggctg ttcgttttta actacttcta ctccagactt aatgagtatg tcatcccagc 63060 cagacggatt gcgatcatat aactcattat agacgactcg cttaatcccc gactgagcta 63120 tggcttttgc gcaatctgga cacggagaaa cagtaacgtg catttcagca ccatcgatac 63180 tttgaccggt tttcgcggca tacagaatgg cgttcaattc tgcgtgaatt tcatttgcct 63240 ttgaccattc actgtgggct tgccgataca ttcctcgcaa cttaccatga gaatcaagcc 63300 aaccgctttt cttcgcatga tcatcgcaat tagcatggtt gcaaccagct ggagttccgt 63360 tatagccagt cgaaataatt cgaccatctt tcgaaatgat agcacctact ttccacgaaa 63420 cacagtgaga ttcttgtgca acgatatagg catgttgtaa tacacttgta tctttcatgc 63480 gattacccga gagcaactga tgataaactt cggcacaaga ggttgggcca acgaaattgc 63540 aaacaaataa ttgtcacgtc cacctgcacc attggtgacg atcaactcaa attcgttgat 63600 gcttatttga gttattgaaa ccatcgcatt tttgtcgcga gctttaactt tactctggaa 63660 ttcgctgcaa cgcttttcca actctgctag tgcagcttcg taggtgtcaa aaaacatttt 63720 gttactccgt tttgatcatg tgactatatt atcacactaa accgacatgt acactacttt 63780 tattgatttc ttacaaaaat gccctccgaa gagggcattt gaatcagaaa tcaccaggtt 63840 gaacttgcca gcattccagt ccgatacgac gccacatatc aacaaccttt tgacgatcat 63900 cgattgcacg catagcacac caattgggct cgatctgttg ccagaaaatt tcttctttta 63960 cgatatcgtc ggagcgagaa tcgcctgcgg cacgctggta atgagccgcg gggaaaagac 64020 cagcgttatt cagagccttg atagaatctt cttcagaaac accgtcgcgg ccagaaacgg 64080 taatgcaggc ataaccacgg tcaacataca ttttgaaaag ttctacaaca gagtcacgag 64140 gagtgtcatc cagaactttc gaccaatcaa aggcatgcct gtggttgtta tcaaacaagg 64200 tgccatccag gtcaaaaatg attgcccgag gttttgcaaa gtcaggagta taaacccgtt 64260 gacctccaaa atcaaccata tattggtcat attgacgctt cacgacgaat tcaggcaaag 64320 cccgctcgcc cttatagcga ttacgctcca tgagagtaga cagaaggccc ggcgcaaaat 64380 atttcagcac aaactcaacg ttatgagtat ctgcgaaatt tttccaagtt ccttgagttg 64440 tcttattcag attggtgtcg gaaataatga tagtcttgct catggcaata gcttcgatcg 64500 ctgctttttg aatagcgttc gttaccagtt gctcattatg cttattgaac ttgtaatcag 64560 accaagtccg gcagccaaaa aggctaaaac gaaaatcatc acgattcaaa ttaacgtatt 64620 tcgtaggatt tgcccgaact tgctcatttg cccaggtgct ttttccggaa caagtaggac 64680 caacagtcaa aatgagttgt tgagatgcga aacgttcagt cattaattgt atcctcacat 64740 atttgaatta tttgtttttg atctttgaca tatctgttga catcggttaa ccatacaccc 64800 aacttattgt aatcctcaaa acttagtaaa gctccatttt cggttgcttt ccatgttata 64860 tcgagtttat gtatcggcga tggttttggc aacatgggct tagatgcaca ggatgtgatc 64920 aggagacatc cgagtagaat gatgatatac ctcatttcgt actctcctga agttgatcag 64980 ctaacttctg gaagcccata ttcattcgtt tttctaatag ttgcggtttc ttttccgcaa 65040 ttttttccat ttgctttgtg gcttttggag acttcaacag cgcctcagtg acgggttttg 65100 cattctcata cgacttagtt tggaatgatt tcatcgattc caaactagtt tttagcgtag 65160 agatttcgtc atgttgattt ttcatcataa tggtcattaa gaccattatg atgatgtata 65220 gcgcattact ttttagccaa ctgagcagcg aactcaaagt taacaacatt ttcgcagaat 65280 cctttgacaa gagcgatgcc ttcgctccgt gtcaaaccat caatcaaaat gctttttccg 65340 ccttgacgaa tatcaagttt ggcatgttgt gggaaaacat acttcatgcg gcatgcatct 65400 ttatgagtga tgtttacacg aattttgtca gtcagtggag acaagataaa gtagaacttg 65460 gctcccatga aattgacatt cggcatcgtt tcgttaataa acacctttgc gggtgtgcct 65520 gcaaaaacat ttttcaactc gttcacaacc tcattgacca ttggaccaat gttagtttta 65580 gcttgttgat agtattcccg agagtacgat ttggattttt ctttcttttc agctgcagaa 65640 tgagcagctt tgcgcaaatc ggtaatatat cctacaactt taccgttttt gtcgaaaatt 65700 tgaattccat ccgaactgcc gccgagagcg tacatgttga tgagaatttc gacggtgtaa 65760 tgattcattc gattaactcc atgttgatta tggatttatt ctaatcatta caccgtcaaa 65820 tgtacacagt ttttgcaact ttatttaacg gtacgccatt ggaacgtatg ttgcgtattc 65880 tttgatgatg tgctcttcga ttttctcgac agcgagttcg ccgtcccagt cgcggccgta 65940 ctgttgcata actacgctaa aaagataccg acagtctttc attctcgctt gtgcttcgat 66000 agcaaaactt cgacggtcaa aacctcgcaa atcgtaaaac acttctgcac aaattttgtg 66060 gtatttagca acagtatcaa tataagcgga ttcaaaggcc tcgatttttg ccaaagcgac 66120 attatcatcg gaaaacaggc cacgaagatc gtcggaagca cgttctttga tggattggaa 66180 caatgcctta ttgttattga tcgagtcttt ggtacgatgc agagaggagt accagtcggt 66240 cttcagtttg aacagctgac catctgacat aacaccgata actccttcaa tatcggtctc 66300 ggcacgagtt gcagcttccc attcttcggg agtaacttta ctccaatccg gacaaggata 66360 aaccccgatc atacgatgac gaatcaacgg gtcatccagc agagtagaaa attctacata 66420 ttgacctgtt tcattgtgac gtacgttgag aacaatcaat tcttcttcct cgtacggaag 66480 gacaactcga ttgcttggtc caacatattc catattgaaa gtaaaatcgg gaccggctcg 66540 tacaattgca tcgcgcaatt tttcataagc aggcgaattc aacagcacca ttgctttatt 66600 ggcttgatcg gagaaaaccg cagctttaga tttcagataa acgtagcctc gatcatgata 66660 actgctaatc agcgacccat ccgctttttc catcaaaccg atcatcttag ttaaatcgag 66720 cccaatggtc atggggtttt ctttcagatt gaagaacttc tgcattgggc gagccatgat 66780 tcgaactggc tcgtttttat catttagctc aaacataata cctcgacatt ccaaagcatc 66840 atcttgcagc caatcggtat atgaagcgat aaaatagctg aaaattcgag cttttgtccc 66900 catactcgta atgacgtcct tgaagtagaa attgcccttt tcggattttt ccacaacaga 66960 catcaagtta ttaaaaagtt cagttgttct gctcataatt taaccttcag ttttgaattt 67020 agaacaggat taaaaatccc gataaatttt ttctcttctg cgtcgagatc agctataacg 67080 tttgacccag caggagtggt tataacgatt ttgaagcaat gctttatcca aacacaaact 67140 ctcttacccg agtttactgc ttcttccaga aacttggatt tttggatatg cgacttgttc 67200 gtatttttcc aatacttgcc attagcatat gagtccattc gtttgtgcaa attctttgtt 67260 tgaccaatat acacaacttc atcatcaatt gtaaacaaat aaatgatgtg ttttagtgat 67320 gggtctttag caaaatctct ggatatacgt ccgtttttac ctatggtcaa ttctgctatc 67380 tgaatgaatc cgtgttcttt taatgtcata tgaaatcatc tacgcttggc acatccttaa 67440 acatgcgatt aactagatca gcaagaatat ctccgtgaca tggcaatggt ttgcaaccac 67500 accccaattt cttgcctcgt agtgattcta aatcggcaag agtaatagcc ccagttttta 67560 tttggtgttt taaatgcttt ttgtaattgt caagataatc ctgccgtttc caatggggtt 67620 ctccgtatgg attaccccat atggtgcctc gctgtatacg aacgtcacat ctttcatgct 67680 tgacgtttac aacggtgcat atagtcattt acacagccat cggtagttta attgttgggt 67740 gtgggtcata cccgtccagg cggaaatcgg ctgcttccag taaacgcaga tcgctcaaac 67800 tgccgatatc agggaaactc agcgtaggca aagggcgttc ttcacgagaa agcataccac 67860 cgagatgact caggtgattt tcgtaaatgt ggacatctgc accagagaat accaattcgc 67920 caacttccaa attgcaaatt cgagctacaa tatgggcaag aagcgcatag gacgcaatat 67980 tgaatggcag accaagacca acatcgacgg aacgttggct ccacatcaaa ctgagtttgc 68040 cttcatatac ttcaaactgg aacgcatagt gacatggagg caaagccatt ttttcgatat 68100 cttcaggatt ccatgcaaca accaaaagac gacgactgtc ggggtttgct ttgatttgat 68160 cgatcacatt ttgcagttga tcgaccgggt ttttattacc gaacatacgc cattgcttgc 68220 cataaacggg accaaggtat ccatcagaat atccaagatc aacggcttgc ttgttatagt 68280 tatcatccca gatggtttta cgatcagagt tttcgccata ggtcaatttg cgcagatgtt 68340 cgacattggt tgaaccttgc ataaaccaca gcaattcacc cacaactgga acaaatgcta 68400 gacgtttgca tgtggtggcc gggaagcctt tgctgaggtc aaagcgaagc attcgaccga 68460 ataccgaacg ggtgcctact ccagtgcgat cagtcttctt tcgcccattg gtgataatat 68520 cgcatactaa atcggtgtat tgaatcattt ccaaattcct gctttaatgt tggtgcaatg 68580 ttcatgatca actcgatacg cgatagtatt cattttccgt ttacccagga aaactcctag 68640 tgcggtatca gtgatataaa ctgttgggtc aattgtatca taatcagaag taagcataag 68700 aaaattgata tggagttcat cacacttgtt ggcgactgac agtatcaggc caaggccacc 68760 gataatcgat atatcatttt ctggatatag ttcttttacc acagaaatcc agtcaatatc 68820 aatattgatg aaattgtcag gaagttcacc tgatttgttc cggcactcac gcttaggatc 68880 gccaataaca accattaccc ttcctggaag attctttggg agcgactgga atgtttttgc 68940 acccataaca cagatagtcc catcggtttt ttccctgaaa agtttaaagt cttcggggat 69000 cgatggccat ggtaaatcgc catctttacc aaatacaaaa actccatgct tatgaaaatc 69060 cgacggtaca cctaaagcaa atacggcttt aatcacactg gacctccgtg ttggattcgg 69120 ttaattgact tgatatctgt ttcatctctt caagagaaaa ggggcatttc agccccatcg 69180 tattagacat agaattctca atagcagttg caataatctt catttatcca gcatttcggg 69240 cacaagactt gcaaaggttg taatttctta attttcatgt taatcctcgc atttcagcag 69300 gaatttgttg ttgatcgctt taaagtgaat catctggcca tttacaaggt caacagattt 69360 gtaaacgaca ccttcagcaa tcttgtggtt gatggacgga atatccgcat cagccaacat 69420 ttctttgaca gtttcaaatt gttcaaacgg cttgcaacga ccaagctgcg gtaccatttc 69480 catgccgaga gcacggcaca ggtcgtggaa ctcttcatcg gtagcaaaac gttgctcttc 69540 gataaaccaa gcacggaatg cgaaaatccg gtacttgtcg aagttttcgc ggtttttctg 69600 gataccagga cccatcagtt caccctgaat tgcgacagat ttgcccatct tcttcagttg 69660 ttcgatgatt tggtagtttt caacacccat ccaccacttg ctttcggggt tatagcggag 69720 aacctgatta cgagaagcta ggataaattg agcgtcgtcg taatcgtgag catatggttc 69780 atcttcggtt ccaagctcga ggaacaggtc aggatctgtt acccatgcca tggtgataga 69840 actaccatcc agcttcagag acttttggaa cacaacatct ttgtaacgag cgctgtattt 69900 gctgaaaatg ttttggcagc gttcttcatc agttttcgga atgaaaacag ggaaagtacc 69960 ggccgggtta cagccagaac cgtcttgagc cggctcatat ttgataatac cgagaatttg 70020 gtcaagactt tggtccattt cataaacacc gagcagttct ccaatggtaa atgcgttaac 70080 cggcaaagca ataccttgag aaagttggcc gcgaagttta atggtcttca ctcgagctcg 70140 cattttgcct tcgtacatcc tggcacggga ttccaagaat ttgaaagcag gattatccat 70200 cggcagcatg gaatcaattt cgaaatatac gcaatcatca ccaactgcga attcaccttt 70260 cttcacaact acttcccagc cgtcgatggt tgcgcattcg atagcatcag cacccgggat 70320 cggctgaaga tcggcaattt tgcgaataga agccaactga cgttcattat taataatcat 70380 attaatcatt ccttacttag tgaaacatta taagccggag attgttttat tttagtgagg 70440 tcattttatc atgacctcac tggttgcgaa cttattcttc agtctttttg ctcatgtctt 70500 caaattcaag acgcgggcaa attttagact ttttgttctt gacaaaggtg ataatcaacg 70560 gttcttcttt gtacggtggc ttgaaatttt ctttggccca aacaaatccg aatattactg 70620 cgacaaccag cacaatagca gaggtgacgg tgacagtacc tactacagca gcaaggctcc 70680 agtacaatac catattatcg agggcaaagc caattccttc gaagattctg gcaccaatag 70740 atgtgaaaaa agcaatgagc agtaaaatcg agccggtgat ccatgcgatc gtaaacacga 70800 ctttccagaa atacgggcac agagaattag ggatactcgt gtcgagagac ttcagaaaac 70860 gatagtgcca agatttagtg ttaattttca taatatttcc ttttgaacaa tgttttgagt 70920 taaatcactt cgatgtcaaa atattgacgc tctgacataa aaatcgcggg agtccagtat 70980 ccatcgagct caaattcttt gccatcttcg agaatgacaa tatcaccatt ctctttattg 71040 acagcagtca gctcgtaatg ctgcatatac tcagcaattg cgctattagc tgcagataaa 71100 gctgcaaatt tagcacgagc ttcaggagat ttgaatttga tgagaactat gtttgatgac 71160 attttaattt tccttagagt tcgaatctga tattgctggg gaatttgacg tcatttactt 71220 cttcaaactt ggccttatag tccaaaaccc aaccaccgca cggcttagtt ttgatgaatt 71280 cgaaaaattc atcttgacct ccaaacgcag caaccgtttt ttcacaacga cttacatgca 71340 aggccagaat ttcttgtggc aaatccgaac ccttggtgtc aattggataa tcgagaatgt 71400 ctttcatttt tattactcct tggttgattt gatgtagaca ttctacaccg tgtggcatag 71460 ttgtacacta ctttttgaaa gattttgatg caaaaaaagg aacccgaagg ttccttttct 71520 atattagccg agaagagcat ccagatcgtc atcgagatca gaagaagcat taggcacgga 71580 tggctgaact acatcagtgt cgaacgaggt aagctgttcg tcgaagtcat tcagttcgct 71640 agacagagaa gatgcggcag aagcggcaga gccagcagcg atggaagtac ccattacttg 71700 cttgaatttc ttctccagtt cttcaagagg cttgaattcg gaaggagcaa cgattttgct 71760 caaatcttcc atgccatcag tgaggaactt ttggaattcg gggtcgttga tttttgcaat 71820 ttcggattga gccaagaact tgcagtcatc gtagttggta aaaccaccaa ctttcttggt 71880 tttgtaaacg aagtttgcac cttcgaaaac gcaagtcacg tctactggag tttcgcccat 71940 ttccggatcg acgttgatca tggctgtaat tttttccatt acctttgcgc caatgcgaat 72000 cttcatcacc ttgccttcat tttcaggagt ggcagggtct ttgattacca gaatgtttgc 72060 ccaataggaa gtcttacgct tcagcagctt atattcttca gcgttggtgt tgtaagaatc 72120 attgcggctg agatgttggc aaaccgggca gttgtcaaaa tcaccgttgg tagaagaaca 72180 attttcaata taccatttgt tatttttctt gaagccgtgg ttaatcagct taacaaacgg 72240 aagaccttca tcacctttac ctggaaggaa acgaattacg gcttgaccat taccagctgc 72300 atcagttttc agtttccatt cattcttatc tccaccaaaa ccacctgcat tacctttcag 72360 agcggccagt tgagcttgaa gttgagaagg attgctgcgc ttgaacatat tttattttcc 72420 tattttattt tgacagttgt ttttgcgttt ttacatttta catcaatttt gatatagcta 72480 aacatcagct ttaaactctt ttacgtgttg aataaacttg gctttagcta tgtcattatt 72540 tattactacc aatttccggt aattgaccaa tttggtatgc cagttctgcc agattatatc 72600 agctgacatt ttctcatcga ttttgtcgat tataccaagg aatgaatcaa taaccaaaaa 72660 tgtttctgtt ttgatcaggc cagattggag taatttgaaa attgggctcg tttgttgttt 72720 ttcattatac tccaatagtt tacctatcgg aacattgact ttattggaaa aatacaccag 72780 gtttttcagg tcttccctgt atatttcagg gaatctgatg tatcttccca acaattctcg 72840 atgggctgcc attgcatctt cagaaacaag atctccggcc cagccatttg aattttccaa 72900 aaacgttgcc agaaatatct ctgtcaagtc tttaaggtga aatttatcgc tcatcttatc 72960 aaagaagtac ttatctctgc gtttattaaa cgcagcatca gtaactttca tattccaact 73020 atatttgatt atgtcatatt ttccagccat atgttgtttc atcatcaaat aaagcataaa 73080 cgcgcccttt gcactaataa atctatcagg tctaggcgga tatcgaagag cgatcatata 73140 aatctcacat caaaaagtcc aaactatttc gtgtcatcga ttttgcaatg gaaggtctaa 73200 gcatgtcgga atcgacacat tcttttgaaa gtttgtcaat taccgctcgc gggatatatt 73260 tgtggcacga gttaatttct aaagaatttt cttccaacca ctgaacacat gcttccagat 73320 atgtcaatcc agttttaacc agattttcta tctctatccc gtttgcggtt ttatcattca 73380 gattgttcgg atttgacatc atttgccttt aaaggtttgg tcatacactg aagtaacttc 73440 atcggcagca tcttcaaact gctcacgttc ctgcttgtgg taaatccgga acagctgatt 73500 gaacagtttg ccgtcaacac cgcattcagt aatggcaata ttgcgctgct cttttacctt 73560 ttcagcataa gattcttgca tagtgcgcaa attcgatgct tcggtaataa tttcttggag 73620 acgttcaccg tgaacagccg ggttgaattc gactttttct ttctttttct tctgttcttt 73680 catgttattt ccttagaatt gatttacttt atcgagaagt ttaaccaagc catttttaac 73740 aaaatagctg tacaatttac cacgaggatt gactactgaa gaattataag cttgaatgat 73800 tcgatccgaa acatgtgctg gaattttatc caaatcaagc aaccgaacat tcatatccca 73860 acgcttttgc cattcttcat tttccaatgc agctcgaggg tcttcagatt caacgattga 73920 attaatccac ttggtagaac aaggtggagc acgttcacct tcgacacgat caaggacaaa 73980 tgtatcacga acttttattc ccgaaacacc atcttttgca tcacccttaa tcagtttaac 74040 aaacaggtca tgctttggac taccatattt tggctttact gctttcttct gagcaggtga 74100 atattgcttg acacccttgt atttgtgcaa ttgagtaaag tcagagtcag aagaagaaat 74160 cataacacat cgaccttctt cggtgaactt tttgaccaaa actgcaataa tatcgtcagc 74220 ctcagtttta tcaagtttga tcatcttaac acctgggtag atattaagca tttcgttgac 74280 cactttattg ataatactaa agagaagttc ccaatcccat ggagattctt ctttattagc 74340 ctttcggttt aatttgtaat accaagcaat gtcacgtctc caataaccat tggtagaatc 74400 gtcaaatgcg ataatagttt cgggatattc gtttttgaac tttttaacgt tgtttcgaac 74460 tgtatccagg attaaatgtc tgagcattcg ctcatttaca tcttcaggag taaagttagc 74520 cattattgtc gcgataatta attgagatgc gtcaataata ttgacatcat cctttgtggt 74580 ttcacccatg aaatcattta agttcatatc aatttctctt attgaacacc tagacatact 74640 aacataaata actaagttag taacaggaga gcttcaaaaa tgttaggaca agcctttcgc 74700 gccacaagcg gccttgatgc agctggcgaa aaactgatca acgttgcaat ggccgataag 74760 acaattttgt ccgatggcgt tagcgttgga tttttccaca aatataacac aatttacgaa 74820 tatgacagca cccgcgggta tgatgcaaaa catgctgtaa ttttcgagcg tcgaatttat 74880 tacgcgaaag cagatattgc ttccccggca ggagctttcg acgtcacaaa atggactggt 74940 ctccgtgttg acccaacatg gcagttcatt aactcgactg gacccgcact tcagctgagt 75000 tctggtcaat atatcactgc tgacaataga ttcaacaatc tggttttcaa cttgccaaca 75060 tcaccagtcg atggcgatac tttggtaata aaggacgtag gtggtcaacc aggtgtcaac 75120 gatctggaat ttgtatctac tggaacagct gtcattgaat ataaggcagc cagtgtcggc 75180 gctcgcttcc gtgcaactgt cccattctgc caatatatgt tcgtctataa agcagccgga 75240 aacagatggc aagtagatgt agcagctaca gcaatgaaca gttattttgt tgagccatcg 75300 attcaaggat tccagttgca ggcagggatg gttacctgga gacgtacttc tgcaggaaca 75360 attcgcctta ttctgccaaa acatgccaga catggcgatg taattacaac ccatgatatt 75420 gatgggatga acccgattaa ccactcgact cttgagattt acccaggttc aggtcacaat 75480 attaatgaaa tcggtgttac aaaaattgaa tcgcgcacat cgggttacgg ttcatttgta 75540 ttcgattttc cttctttgac ttggaaagta tgggatggag accaaaggac acgtattcgt 75600 gtcaccaaaa cagacacagc actgctgccg tttgaacaca ttctggtgac tggcaacagt 75660 aatttgccaa gtcagaccac cgtgctgact cttccagagg aagtagccat aggtgaccgt 75720 gttcaaatca ccatggatta tctgagaaaa ggtcaaactt gtacgatcag agtaagtcca 75780 gattcaaatg agctgattgt tggttcgaaa gctcaaatgc agttccagcg tcgttcggaa 75840 tacccgatga caaatgggtg ggaattggtt tcatctattt ctataagtgc tgacacagat 75900 tacgttccat atatcgagct aatgtacgca cagttagacc cgtccctagt gggtgttact 75960 tcttcacaat acggatggat gatcggaaat gttcagccaa aagttgaacg tgttgatgca 76020 actcgccgtg atcgtctggg tgtagctgct cttgcggatc aagcagaagt aaacaaaaat 76080 cacgaagata acccgaatga tgaaactatt gtcacaccga aaacattagc taataaaact 76140 gctactgaaa ctcgtcgtgg cattgcccgt ttggcaacaa cagctgaagt caatcagtta 76200 agcacttcaa cttatttgga tgacattatc gtcactccga aaaagttaaa tgaaagaact 76260 gctaccgaaa ctcggcgtgg tttagcggag attgcaactc aagcagaagc aaacggctca 76320 actgacgaca taacaattgt gactcccaaa aagttgcata atcgtattgc gtcagaaact 76380 ctgactggta tcttagcagt ggtttctaaa aatggaacag ctggaactgc tcgctcggct 76440 gctggggctg gcatatataa caaagccgat cattcgaagg ctgtcacacc gttaaccctg 76500 gatgaattca aggctaccga aacagctaag ggtataggtt atattgccac acaggcggaa 76560 gtcgacgggg gatcatctga tccacttggt ccattgcttg tgacagccga aagattgggt 76620 gctcgccgag cgacagaatc aaatcacggt ttgattgaga ttgcaaccca gaccgaaaca 76680 aatgccggaa ctgatgatac acgtgctatt actcccaaaa agttgaatga tcgcacttca 76740 acagaaactc tcgctggtat tgcccgtatt gccaatacat ctgaaataga tactgcgaca 76800 aacgatttaa ctatcgtcac tccattgaaa ttgaagaatc gtttcaacga tacagcaaga 76860 atttcggtaa acgctaccga tggtttgacc caatctggaa ccatttggag cactgtttct 76920 gtcggtataa gtcttgcaac cgaagctcaa cgtgggacat tacgtgtttc gactcaactt 76980 gaggcgaatg gatctagttc agacaatact atcgtaactc caaagaaact cgatggaaga 77040 aaagcgacaa gaaccctgga cggtattatc cgggttgcga caaccgctga agttagaact 77100 ggaacagcta ctaatttagc cgttagcccg gaagacttca agtatatagc gcaaactgaa 77160 ccgacatggt caggaaatga aacacgtcgt gggtttgtca aagcagcaac agtagagtcg 77220 actttcgttg gaaacaataa tgtcggatcc actcaggcat acacaagcta cgaaaatgac 77280 ggtttggctg ttagccctcg tggattgaac tatgcactgc aaaactatct tcctttaaat 77340 gcaactgctc aaaattcatt gaatttgggt ggtgtagttt ccagtgggtg ggttcgcaga 77400 acagtagatc aaactataac tggcgcaatg aatttcaccg caccaatgac cactcaagct 77460 gtcactggga caacatcgtc atttaattta tcctttattg agtcaaatcg atcagatgca 77520 ttgactgttg gctcggctat taatacaggg gtcgctggta ttacctttat tggtggcacg 77580 acaggttcca ataaatggaa actttacgcc ggaaatgaca gcgccattga cggtgtcggc 77640 ggcgggggca ttggatttgc gccaggcgtg gctggaccag tattccaggt tacaatcgcc 77700 ggtgattcat ggacacagcg caatattgta tctcacactg gcagtcttag tcttgagtca 77760 gcttcagcag gaatttcgat gggcggggct cattttgcgt cggttagcac aactgacaac 77820 aggatgaaca ttggcacagg gttgcgcaac gttgtgataa attcagaaaa tgacaacgtc 77880 aaaattggaa tttatgacat cgtccacact ggaaaccagg cttctaaatt gaatccaata 77940 tatctgcgcc gtgatggtgg aaacacccaa accggcaaag tcttggctga aatggctggc 78000 gatgtgaaat acagcacctt ccgaaatgat aaccgctata tttcatcacg tggaaatgat 78060 ttcgtctttg gaaataccga tacaacgaat ggtagagttt gtctcgatac aaacaaaaac 78120 ccaattgtaa aaatcgggaa tttcgaatat gaaatttatc acaagggtaa caaacctacc 78180 gctcaagacg taggcgcagt tgatattaca ggttcatctt ccaataatat aacgattaga 78240 gattggatca aaattggtaa tgtgaaaatc gttgccaaca acttgaccaa gaccgttgag 78300 tttatctggg aagaataagg aatcgttatg gcagaacaat ttatggccca tcttgggcca 78360 tcttacgttg aatcaaatca cttaggtgaa aacaacgcaa taaagtacat gatacaggca 78420 cttggagtca ataatgactc cagtgtcaca gtgccgtatg tcaaaatcaa tggtgtttcg 78480 gttttgcctt cgtacgggag gggtttgaac gctatcacta tttctccaac cggagtagca 78540 tctaattttg cgacgtttga catatatgct agacccgagc atcttgacac tttaagaaca 78600 tatctaatgt ctgcaccatc tgacaatata gtagtagtag tttcgcatga tgctatcaga 78660 tcgtcagcgg attttgacac attcatgaaa cagtatggag ctatgtcgtg gcctggttct 78720 agttatctaa atcgacaatc tgatgctctt tttactccga gagcatatag aagttcatat 78780 gctgcaattt tcaatacgac gttaaagcgt ttttgctacg agaattttgt tgggaataat 78840 cctaacagtt tcacagaaga cacaaatgcc tatttgcaag ttgtttttga tgacgttgtc 78900 gatattggag catgtggatt accatcaaga aatgtcgatg acataaatga atatttctca 78960 gtggggaatc aatacggatt taagggttat ttatatgaaa atataacaca atgggaatca 79020 atatatcata tccaatgcga gctgcacagc gaccagacac tagttaccgc cggtggaaga 79080 tgtatttttt atgtatggac tcaagactct tcaggcatat ggaaaaccag tatatggcta 79140 ggaacacaca caccgacccc aggtgtgtgg acaaaatttg aaggttattt caaactgcca 79200 acgcaaagct caggggcgac gatttttgct tctgcagcat accgatttcc gtcaaacgtt 79260 agtgctggaa cagcaggtgt gcgaaatgtc actataacgc gggttacaag ggacgatgat 79320 gataaagtgg cggatgcagc aattggtgtg aatggtatta gagctaatag cataagcaat 79380 aacggcaatt acacaaatcc tgtattacag cttttgaatc tgaaaccaaa gaatatcatt 79440 acttcaaacg attttaacga aagataaggg cctcttggcc ctttgtttgc tttaaataga 79500 ataaaatcct ggcttccagg ttttggccct gccaaaactt atcctttatg gcttaataga 79560 tattataact aaaaggataa aaagataagt tcaagcaagc ttgaacctgg agccaggatt 79620 gcttttaatt cgagtgcttt aaatataaca agaaatcacc aatcattggt taaacaaggg 79680 agcccatatg gcagatttaa aagttggaac cactgtcggt ggttcacctg tttggcacca 79740 aggcaatctt gcactggtac caagcggtaa tgctatcctg tacaagggtg caagaattta 79800 ttcggaaaac gataaaccaa gtgcaaatga actccaagta gtatctcgtg ctggcgatac 79860 tatgtcaggt gctctgaaca tcgaaacttc cactgattac ccattagcgc ttaagtcaag 79920 cgttagtggt cctgcttata ttcgtttttc aaagggaaat acgcttcagt catatgttgg 79980 aactgatgct gcaggtgact ttaaagtcgc aatgactgac gctaacggct catgggcatt 80040 tgatgggctt aaaatcgcta aatctaatgg tgatgtttct ctgaaaggag cgttggtatc 80100 cgctaatgcc ggaaactttg atataaagta tggaagtgtc cagttcattc gagcaaactc 80160 gtctaaaaac ctgtatattg gcgcacctgg tggaactgat ttggtgcttg gttatgccca 80220 agatggaatg actaccacta aaattcgctt tgattccgcg gtatataaca aaaccggcgg 80280 acttttgatt agcgacaccg gtcttatcca acgctctgct atggataatc catactataa 80340 ccagaccgaa gctgatgcac gctttattcg tctgaacgtt aataccgcta ccaacggcta 80400 tttgctgagc agatcggcca atgtcgaatc actgcaggcc ccggcgatgg gctattccgg 80460 attcttcagg cacaatggtc tggccggatt ccgtgacttg actattaacg tttctcatcc 80520 ggcggccggt gagggcgcat atgcccgcgg tatcactttc gattacggcc atgtcggtta 80580 tggtatgtac acatatgcgt acgactcagc aggcaataaa ttagcaaacc aaaagattta 80640 tactgaagct gataaaccta ctcctgcaga aattggcgcg ttggctgctg gtgcaaatgc 80700 tgtatctgca tccaagttgc aaaccgcaag aactatcagt ttgaccggag gcgcaactgg 80760 ctcagtatcg ttcgatggta gtgcaaatgc ttctctagca gtgacagtaa caaacgacag 80820 ccatacacac tccgattacg ttaaaaaaat cggcgacacc atgtctggca atttgactgt 80880 tccaaaagtt cttttgtctg ctgcacaagg cgctgaagct aattctgttg ctcgtagaga 80940 ttttgttgaa tcgactgtta ctgctgctgg taaaggtgtg aaagatttga cgatcgcact 81000 tcctgctgga gcaccgtctt ccggatatat tccagttctt tttaaaacgt atgatacatc 81060 cgactcattt gtctttattg acaccttgac tagtcaaggg tcgcacgtga tgaacaattg 81120 ttcatttata ggcaatgttc gtgccagcgg atggactgat cgtgtgagtt atgccgtagg 81180 catgtttacc attcacaatg catcagaaag agcaattcac tcaatccacg cgccatctga 81240 ggatggtctt gcgtttgttg tttacgttga aacacgcgct ttcccgataa cagttagagt 81300 cgatatcgga acaaccgtca ctgctcatgc gactgatgtt acatatggga catctgtctt 81360 taaggttaac ggccaagtaa gtggaaatac aagaaacatt gttcttgcta actttgataa 81420 aggctctggg acttataacg gaagcaatcg cgtttacgat aatgggtata atccaactcc 81480 tgaagcagta ggagctcttc cagtcagcgg aaatgctgta acggcttcta gattgcagac 81540 agctagactt attgcaggtg ttccgtttga tggtacgtcg aatatttcga tttctgcgac 81600 taacgtaggt gctgtatcta aaactggcga taccatgact ggtagtttga ccataaatag 81660 agatttttct catattaatt ttgggcttgc aagcggattg cgcaaaagcc atttagaagt 81720 tgcaccatct gtagtcctta gggttgttga atccgatgtg gcagttcata cagagttcat 81780 acctggaggt gatctcaaag ttagaggaaa cctattctct gggtctagta gggtttatca 81840 tcaaggcttc aaacccacag cagctgatgt aaatgcggtc ggtcgtgtct ttgcaggggc 81900 caacccgatt gatctaaacg ctcttcgcac tgcccagcac ttgcgcttag aggctgttgg 81960 taatatcacc aaccgtccat ctgatgatgc tggttatgcc cagatgatcc atgttaatgg 82020 tggcggggat acgcatatgc aaatccttgg aacctatagc actggaaaac tgttctggcg 82080 tggatttagt gacagtatgg cagctggttc tgttccatgg catcagattt atcacactgg 82140 gtttaagcca tcgttaggta gtgacctcgg cttacagtgg caattgcctt gggttgacgg 82200 aacatctcta tacatcaagc ttgtaactct tggcctaacg gataatgata tcacatttgt 82260 tttggctggt tttggcgatt atggggcagc caaacgagca acttatacgg ttacagcagc 82320 tacccgtgcg gctggtattt ctgttgatgt aaacgcgctt gatgtggatt tgttatatgg 82380 tgcaaaaccg attatttacc atcgcagagt tggtgaatca tttgaagttt ggttaaaaac 82440 accatcttac catatgaata cgacattcac acgactgtct ggaaatggtg gtgtggtcaa 82500 tattgattct tcgacaacaa ctgaaccaac tggtttgact gcggttacta taaatcagat 82560 ttacaccaca cggtttaagc caactcctgg ggatgtaggc gctgttaata aaactggcga 82620 tacaatgtct ggttctctgg ttatcaataa gagtgattgg gcaatcattt tgaacccaga 82680 accaaataca gcttcttata tccttggcca acaaggtggt gttgctaatt ggtatattgg 82740 taagggttca tcattttcaa acgatataac acttaatagt tatgcacatt caacgtttat 82800 atctcttaga tcagatcgta taaacgtaaa taaaaacata gtaacttcag cagctcaaag 82860 ttcattagat aattcattaa caagaaagga ttacgttgat ggtaagttgg acaaatcggg 82920 tggtgtttta tctgggccgg taacagttgt tggtgcaacc gcttcctcgg taacccataa 82980 tgaaaacgga atacactata agaacagtgg gctgatgcgg tggaatgctt atcatgacat 83040 tagtaacgat agttaccata ttataaagta tgataccagt ggtgctttcg ttggtagtgc 83100 aatgtcgata gactacgcta gtttagcaac atcgttttct ggtactctgt ataccccaac 83160 tcttaaggtt ggtggtggta atatagatat aagccatggc ggaacaaacc agatgctaca 83220 attccataac ccgggtgtag ctgctgcgat gatatatcaa tctagcagta acttgatatt 83280 ctgtcaaggt aatggggctt ggggtaatac aaacacatgg cttgtgttga acaataatgg 83340 agccaatttt aacggaatag tagctgctcc cgattttaac gttacgtcag atcgtagatt 83400 gaaatccaac ttcaaagcta tagataatcc gctatctaag gttgaacagt tgaccggcca 83460 aatatatgat aaaaaactaa aggatggtgg aatagttagt gaagcggggc ttattgcaca 83520 ggatgtgcaa aaggttcaac ccatgtccgt tagagaaggt gacgatggta tgctgtcaat 83580 atctccttcc ggcatcattg ctcttttggt tgaagcagtg aaggaacttt ctgaaaggat 83640 aaaagttttg gaaagtaaat aatagcatat ggggagaaat tttctcccca ttattttaag 83700 gattaatcat gcccgtacct aatataccgt ttttactatc tcaagcaggc actgaatttg 83760 ggggcacttt agcctcccaa attatgtcta atgctggtct gggtactact ggtttagttt 83820 caagactggc cggtatggcc cgtcttcaga agattgcttc tatacaatcc gttgtcactg 83880 gaaacaatac gccgccatat gcgacgttta gctataatgc atcaaccaat cagacaatct 83940 acacttatat agatggcaca accgttaaat cttaccccat tttcaatggt agggcgtggg 84000 tgcgtatacg aaatggtgga atcacatatg tcaactgcac agaggctcgg tggtatcaag 84060 tagatggcgt gcaacgtggc gtattaaatc caaacaaggg aacagttcga tctcaaactt 84120 acgagttcgc tgccactgaa ggcggaacaa tagtttatac tgtaactgct gcgttgaact 84180 ttatataaca ttaggaggca aaatgtctca acgacatggg cgattttgga gcatagggta 84240 taacgcgatt ggttatactg gtgatatcaa aaagccaaat tggtttacta acgtccggcg 84300 ctttgccgga ctatcagccg caggcaacgc ggcagacccc cagctgtcat cgttctattt 84360 tggtcaagga gcaagtccta acggaagatg ggtttcgcgc tatttcaata aaagcagatc 84420 accttcgcgg tgctacatgt ggtctggctc tagatatcca tataaccgca atcagaattt 84480 cagttactct acagaattaa ctcaagtaca acgtgcaact ataaaggttg ggtacattgg 84540 caccgggcgg gcttcccacc gcgggggaga tctcggatac gttaatctac gatggagatg 84600 ggataaccag ccatggcaag aaactcgagt atacacgcca ccagatcaat atgtttctga 84660 ctggtatggc tcgcgcactt tcaactttgc acacccgaca ggtcgaggcc gaatacaatt 84720 tgaagtattc ggaaactatg gagattttga tcaacatgat gtgggtgata gaggtcaaaa 84780 ttcgtcatgg tcgccatatt tgaatatggc tttgccgggt gccgggcatc ttgcggcgta 84840 taacggcgag ctgtttaaat ccttttctgg ccatcaaacg cgagaatatt cggaaaataa 84900 ttaaggagaa agcgtatgac gttagaagac atgctcatct atgatgaggg aagagtttta 84960 aaagtgtatt gggaccatct agggtaccct actgttggga taggtcacct gattataccc 85020 cagaagacaa ctgatatggc cttaataaac catacattga gtaaacaggt tggtcgccag 85080 gtgaacgggg ttatctctga gagtgaatgt agtgcactgt ttaactctga tgttcaaaca 85140 gtcaaaagtg aaatcaagaa atatcctaat atcaaattag catatgatgc ttgtgaccct 85200 attagaaaaa atgctatttg taacttaatg ttccaaatgg gaggtcctcg tctatctgga 85260 ttcaaaaaat cactcgcatt catagccaat aaggactggt ctaaagcata ctctgaattg 85320 cttaattcat cttgggcaaa gcaaaccccc aacagggcaa tgcgagttgc aaaagttgta 85380 ctaactggca caatggattc ttataaatga catttcggca ccgttaggtg ccgaaagcat 85440 taaatagagc tgttatacag gagtaacaac tttatgagta cagaaaacca aacgcaggga 85500 actcaaaccc ctggtcgtgc ggggattctg atggaaattc tggaccgatt gttcaaagac 85560 gctgtcaccg gcgaagttgt attttatcgg gcaattttgc tgatccttgt attcatactt 85620 ggtttcagtt ggtacaacaa ggacgaaatc ttcaatgttt atcgagatac tcgttttcaa 85680 aattaccagg aaattcttca agccgaacgc gatagaaaat ttgaggtagc gacacaagaa 85740 cagcttcaaa tagcacatgt ttcaagtcga gcagattttt cagttatatt ttcttttaga 85800 cctagaaact tgaactattt cgttgacatg gtcgccacgg aggggaaaac gccgttggaa 85860 cttgtagata tggaaaaggg cgggtatcca ataaacaaaa catctaatga atatatggtc 85920 catttgtcag gaagacattt tagcaattac aaggattttg cgtttcttcc tgcggggcac 85980 agtgagtttg aatacatgta cagttgcccg attgtgaact tagacaacgt ttatgctggg 86040 gcagtatcga tgttttggcg taaaaagcca gtaattaatg aaaacaaact tttcgttatt 86100 tgcaatcaag ccgaaagact tttgagtaga gctagataaa acaaagggaa ccttacggtt 86160 cccttttttc atacttgttc aatagcgcct gagtaatccg ctggtgtttc tggacaatga 86220 tcttgatagc ctttcatcag caatgcccaa ccggtgtatg gagcatcgtt gctgtcgccg 86280 tctactccat tccaagcaat tccgcgagac caaatatctc catcctcgtc tagtgaatcc 86340 acgaagaatt catggccatt tttgatgccg tgctcgtttt caaaacgaga ggcgtcgatt 86400 acacggtact ttttatcgat ttcgatttcc ataatatttc cttagttgct gtttgtgtac 86460 atggccattt gatgattaac atctcgatga ccttggttga acatttctac taattcttca 86520 cgctgatcag ctggtagacg cttcatcatt tgtctaaaac cagctcgagt gaactcttcc 86580 ccacttggtg attttaaacc caattcgttc aagaatgata cgaaaagttc ttgattgttc 86640 agaatgtctt cacagccaaa tttgatcaga actgacgcaa ttgaaatgat ttcttttatt 86700 gtttcgttat atgacatgtt gtttctctta tcaatacggc aaaatttgat atgttacatt 86760 ttacaaaaat cttttcaaaa agtacatacc tttttatttt gcgataatat acaacagcac 86820 aattggccaa aacagagtga tcaaaataag aaagagagca atgatcaaag gggtgacaac 86880 aatgttgtaa ttaccaaaca acgcttgacc cgaagatttc aaactttgcc atttttctaa 86940 aatttcgttg atttggtcgc ttgcagaaat aaagcctttg ctaactaaag caactaaaat 87000 caatcgcatt acgataaacg ttgcaattgc aacgcttacg attttccaaa catcaataat 87060 tagttccatc attgtacgcc ttcttatgtt tttgtttgcg cttttctttt aagcgtcgtt 87120 tcttgtctac atgagctcca cctttgttga agtcatgttt agcaactgga ttcaaaatct 87180 ctcctaatca aacatgccgc aaatagcatc caaaaatgca tattgattcc aaaaactagg 87240 gctcctgagg agccctctgg ttattagcaa atttgagcaa tattggcctt cataacttga 87300 gcagctttga tggagtcact caccagggtt tgttcggcgg tcaaattgtt cattatggcc 87360 gaatgacgtt ccatcaaatt cttgatggca agttcatgcg cttgcagttc attttgtcgg 87420 cgagtagcaa tttggtcaag agtctgcgaa tcagcggaga ttcgatcttc gagttgcttg 87480 aaaatttcaa gagcatttgc tcgaatacct tcaaccgtag gaatttgggg ctttacttct 87540 gcaccaccaa aatatttcat gataagacca tttttcggat tcatttcatt tctccatttg 87600 gattaaccgg tgtgaaccag cttgattgtt tttactaaga tgaataacca tattaaggag 87660 ctggaggaat tcctccagct catccgtatt acttcaggag tgtaacttca gcaacatcgg 87720 cccaatcact atcagtgttg atgaaatcgc cgaggtagag ggcagtccgc agagatacag 87780 agcggaggcg gtccacattc tctttcatcc attccaatgc gttaacaact tgtgcttcag 87840 acagtccgcg tttttgcagc atatcagttt tagtgattac gtcttccact cgaaccatga 87900 tttcgcggct agtgtgaaca ccaaggtcaa ggtagatgga gcgagactgc agagcatcga 87960 ggtgcggagc aagtttagtg ccacgatcga tttcagcgtc gatgtcagcg ttggtgatga 88020 agacgatgga acctttgaac tcgaagttgt ttgggatatc acgttctgcc aagtagttgc 88080 tggcagtacc ccatgtgatg atgcgttcat cgccagtgtc aagagcagct ttcagtacgt 88140 tgagggtgtc ttcgttagag aacacatcga cgtcatccag cagcacaaca caatcttctt 88200 cacgattttc ccaaaggtgg atgtagaggc caatgggaga gcactttcct ttgatggaag 88260 agaaagagat gtcgccaatt tcatcagagt gtttcagctt tttctccaag ctgaaggtct 88320 tgccgattcc aggagcacca gagataatca gagaacgaat ggtgccttta acaagaccta 88380 cggtcatttt gtccattacg tcgaatcgtt ttgcaatgcg agagcgcatt tcgtcaacag 88440 tttcttcagc aacgtcagtt tgagcaacac cagcaaaact ttcggtaatc acgatgtcat 88500 tgcgatttac ccaaaccatc cgagatttgc ctttcagaac ggcattaact ttaccttcac 88560 ggggatcgtt ctcgctggca tcccaccagg tgtttccgtt agtttcaaaa gtaccgttaa 88620 caacattacc aaagtaaaga ccgtttttga tggttacttg cattttatat actccgtgtt 88680 tgtgtattcg tttatttgat gaggctatag tatcaatagc ctcatcgtga gtacacattt 88740 attttcactt tttatcgcat tttctgaagc atactgtgtc cttatactct tcggatgaga 88800 ctgaaatctt caggaacaaa ggcatagtac tcgcaatcta ccagcggttg gccatcttca 88860 ccgatgatgt caacatagat tttccgagaa ccagcctgct tgactgttac gacgaacggg 88920 tgggtcggat cgaatttgcc gtcatatttc attagaccgt cgtcatcttc acgattcagc 88980 cagtcgttgt atgcttcaat actgataaat tcgcaaattt cggttcccgg aaactttagc 89040 cccatggccc ggcagcgata cagtgcactt ttgtactcaa gtcgtttaat tgtcgcttta 89100 acatgttggt cgtttgtcat tttcaattct cctttatcaa gcaatgccat aatatcaagc 89160 ataaaaacac atgtacacaa caaaaacgaa aaaaggcccg aaggcctttt cagatatcaa 89220 acaactccag agttttgtta tccttaaatc cttcatatcg atagaacggt aaagcaagat 89280 gcaaaccttt catagcttcc aagcgagtaa agaatgattt tgggtcttta tacgtttcga 89340 cataccagct gtttggccaa gtatgaacct tgaaaccgtg cttgaatgct atttccgata 89400 atccattatt gaaaatgttc atccacgaat ttctttcagc ccaactgcca ttaaacgatt 89460 ttccgttaag catattgttt gttgggattt ttcttgactc atcttcaatc ggaagcaagt 89520 gcacaagttc gatttctcca gtaacttgtc cagactcctt tagcccgact aattgttttt 89580 catactcgtc aagcttttct agtacatccg aaaccgggtt attttgcaaa ccgaaatgat 89640 accgaacgtc gatgtttcca aaataaattg tcaaattccg aactttagca ggaaggaaac 89700 ttgacaatcc ccttttcaaa gctccacgca atgtttgtgc gtcacaccga taagccttat 89760 agcccggttg ccacaccgaa atgctgtgag aatccccgag tgtaacatct tcaagcggca 89820 aagaagccat tgacaaacaa gtagctttat caaactgtgc ttgaatggaa tcccaatcaa 89880 ttcctctcca tagctcggga actttcatgt tgggttcacc gtgtttgttg aaacagcgtg 89940 ctttgcagaa ttcaccaaaa cgggccaaag gtttgtctaa tgcaacaatt tcaccggtga 90000 atccttcagc gcatttaata aactcagcgt attgcggctg aggaccacca aacaaactca 90060 atctgtcata cggctcaaga ttgaaataga catagacccg atcatattct gaccatgatt 90120 tagcctcatg catcaactcg catggaaaac cagtgtggtg ttcgatagca gcttgccaca 90180 ctcgtgccca ggccattttg tgtgatttct tgttacgcga aatcgggctg aatagcctta 90240 caataatttg cttcataaaa ttccccaaaa agcggccgaa gccgctttgt tacctattaa 90300 gccataactt gagcaagttg ggcttttact ttttctttat ccaacggatt cgacttgtaa 90360 tagtctgcct tttgacgagc agccagatcg tcaagctctt catcgctcat tgcttcaaga 90420 ccttcaagag tcaagcccat gtaagaagga ccaaacaggg cagcttcttc ttcggacatc 90480 atgaagagca cagcacccat atcagcacac tgacggggac gattgcgcca ccagttagag 90540 ccgaagtttc cttggtcagg atagaaaaca gcgcgggcgc ccgagtaggc ttgaattact 90600 tcaggctctt tcgcaagttt ggcatcaacg tcaatagttg cacgaccaaa tacttctaca 90660 tcccatgtga agttgtcttt gaacttgcac gctttctttg taggaagacc accgatgccg 90720 gcaataatcc atttgcgctc gcggaaaata tcttgacgag caagacccat ttcgcgcagc 90780 cgatcatctg ggctaggaac ataggattca gggcagaacg aataagattc atgcggataa 90840 tcgaaaatct tggaaacttc gaatttgtcg aatgcacaat acagaattcg gtgagaatcg 90900 aagacattct tggcataacc cttgacgatg tcttctttca gagaaggatc ggctgtaata 90960 gcatctacag cagttttatg ctgatcgttg agcataaatt cacggaacag aacttcttcg 91020 aattgttcac gggtacgagt ggcagacttt ttgaagcctt tcatcaaacg ttcgggggtt 91080 tgccagtcgt caataacaac gattgcgtca ggacgatttg ccagaagcca atatacgcca 91140 taaccgcctg gttgcatgcc accagtagca tcgaaataag cagtgaagac tttgtcatag 91200 ccactcaggt cttcacctgg agtaacgaag cgttgatcaa catcgtggcc catatctttg 91260 agagcttcga caagaccggt agttgcagtc acaagacgat agcgagaacg tttttccaga 91320 tgccaatcgg ggcgagcatg atagttgtta gtgccagtta caagaatttt cattttattt 91380 ccttttgaaa agccgaccga agtcggcatt aattacgctt tgaaatctga aacgatatca 91440 agaccattac gaactgcttt ccacatatcg atatattgat atgcacccat acggccgata 91500 aacatcattt tatcactctt tgcatgctca gcatacttag catagagttc ttttccgtga 91560 gtcactggat aatacggctc gtttgtgcca tcgtagtcgc atgggtattc gtaagtcacc 91620 atgtcaccat cgccatggcc tggaatattc ttccaaaccg tgtaacgggt atgaccttcc 91680 tcagaagcag agttattcac ggtagtaatt ccatgatcat gcttctcttc ttttacttcc 91740 atgcgcaaag aacggtacgg caatttgcca aatttgaagt catagtatgc atcgatgggc 91800 atcgagttga aaatgaagtc atattgagct tccatgtcct tttcgaatgg cgtgcgaatt 91860 ttgacctcga ttcgttcatg gtcaagcatt ctttcaaaca ttttagtgta accaccttcg 91920 ggcatatatt ggtacttatc actaaaatat cggtcatcat cagaggtgcg cacgggaatc 91980 cttgcgccaa cagcacattc gatgttttta ggatcagtgc cccacatttt cttcgtgtat 92040 ggtctaaaga aaatatcggc aaggtctttt cctacggaat gatcgaaaag ttcatcacag 92100 ttggtgggag atttcgtatc tcgaaccttt tcaaaatact tgatggcctc ttgctccgtt 92160 tcaataccat agagctcttg gagtgttttc agattcactg ggaaagagat taatgtatct 92220 ctatattcaa cttttacctt gtgctcgtag ggaatccagg aagtccagcg tgaaaggaaa 92280 ttgtgcacat ccaagtcgct atgatgcaaa agatgtggtc cgtacttatg aactagcgtg 92340 ccatttcgaa cttcgtcata gcagtttcca ccaatgtgtt tgcgtttgtc aatgactgtg 92400 atgtcatgcc cttgttcagc gagacagcgc gcaatagtcg ctccagtcaa accagcacca 92460 acaattaaaa ttttcatatt tttcctcaaa tgaaatcaac catcacatta taacatgcga 92520 tggctgatag ttttcttagt tgctagtatt tagtcacgtt agttagcggc ttgaatttct 92580 tccatcagac gaacgatgtt gttttcattc gcggcgatgt cgatgtagca gtttgccgga 92640 ccttgcttga tttcacaacc caaagtcttg aagttgttga tgatttcttc agatactttg 92700 taaccaacga tacggaagat gccgcggttg agaatttcga atttgcggta tccatcagcg 92760 tgacgtttgt tcaaagtgat ttcgtagttt tggcgattga tgactgcttg cttgtgctcg 92820 ataccgaggt tggacagcag tcgctcgata agctcgatat ttttagtcat ttcgacagtg 92880 atttcgcgag ctttgcgagt tccttttttc ttttctactt taggcgcttc aacttcaggt 92940 tgggcagctt tccacatttc ggcagcttcg atgagaatgg catcaccaca gtcagtggtt 93000 acgtagccgt cgccggattt ttcgatcaaa ccctttttca tcatcacgcc gatattggag 93060 taaactgcgt ttttgttcat ctcggtggct tctgcaattt cagcagcagt aatgaaagct 93120 ttctttgcaa cttggatgaa gacagaagta gcgttttcag agatgctgga attgttcaga 93180 acttttgcga tagcttcgat tttggtcatg gtcattttaa attactccgt tttgatttgt 93240 ggtagtttgt ttaacttgta gctattttaa tcaagtggtt tagcgttgta aaccactttg 93300 ttgaaataac ttaagctttt ttcatcgctg cgacaagttt gcatttcatg gattttgcaa 93360 gtttagcaca atcagcattt tgccacatca gatcgtcttg aataatatcg ttgaagaact 93420 gttcgcaacg attcatttca cgcttgtcga gaacttcgtt gttcatcaat ttgttgagcg 93480 gattcatgat tactgcgttg atttcaaaac cttggaaatt ttcaacagct ttcttcatga 93540 ggttgatctg cattacttgg attttggtga tgttgaacat ttgatatact ccgttgtttt 93600 taatcagttt gtttggtatg atgctatagt atcaccatac caaacggagt acactagttt 93660 ttgcattatt ttgaaaattt catgcttttc ctcaaagatc gctgagaaaa tcggcgataa 93720 tgctgtttgt ctttttgatt cgttttggca tttcgacgct tggttcgctc cagttggagt 93780 tatcgatgaa ttctggattt accttatact ccaaaaatcc aagtgtttgt ttcttttttc 93840 ctttgatgta tcgtgtggca gcgtctgaac caactcgcaa tacctcagaa tatcctacga 93900 ctttgccttt gcacattatg acatacggtt tttgcagttg gccaagtgtg caagttttcg 93960 caggagttgc tccaagacga acagccattt gctgccatac ttcatcgtgg ccatgaccta 94020 tagttgccca atgagcaagc tcatggttga ttgtatcttt aatggactcc catgttgcat 94080 attgattttg tttttctgaa attctgattt cacggttacc gtaatggcat tgaccaacat 94140 aacccttgtg atttgtaaac ttgagagtat aagttggagt tgtaatatcg acgatatgat 94200 tttcacgcat ccattgtacg cgttcctcat aataccggct gattttgttt ttcagcgctt 94260 gtgaaatcat aatatgctcc gtgacagttt cagtttgttt aacttgaagc tattctatac 94320 aatctaaagc agttgtacac aattttgtca agaaacaaca aaggcctccg aagaggcctt 94380 tgtttttatt ttgttaaagt ttcgaggtct ttaacatatt cgttttctgg agtagtgcta 94440 gaccagtact cgtattcttt ggtctgtttc agcgcttctt cctgaagttt atgagtttcg 94500 tcttcagtta gacggtaaat gctcatacca actagctcgt tttcaaatcc tgccatattc 94560 ggtttggact ttacttcggc aatgagttgt gctttcgatt ttccacgaag aacaattttt 94620 tcttcaatca cttcattgac aaaggcaaat tttgcccaag ccaaatcgcg cgaatattct 94680 gccttttctt tttcgaaatt aacacgctgg ttggtgtatt ttttgcgata ctctacaaag 94740 tctcgaatca gatcggcggc acattcatac tctgccaatt ttccattctc gtcaagaacg 94800 gtgatgtttt gcgaaagatt ttggcgaagg ttgaacattt tgatgatacg ctcatgcgca 94860 acttccggat ttttttccat caattcgcca aatttatcct gacgtttgag agttacttca 94920 aaccggaatc catcgcttgt ttgttccttg tagcctacga tttttccctg ttcctcgagc 94980 ttgtcgagaa tactgacgta ctcaagacga tcatatcgaa ctggaacttc ggtaataatg 95040 agtttggttt gtccaactag ctcatataga ccttcgattt cgatagattt tgaattgatg 95100 cggcgaacaa tacctttaaa gcatgggaac tgaacttccg gttcagggat ttcttcacct 95160 tttactgcag ccagtgtgca cttcactaga ctctcgtaag aatgtgggaa aattgtagta 95220 gcatagccag tggcaatacc ttttacacca tttgcgagaa ccatgggaat aacaggcaga 95280 taaaaccgtg gtggcaaatg ctcggggtct ggatgcgccg gagaaagaga aatgtcttta 95340 tagatgtccc agaaattctg atggacacga caaaacacat atcgtggtgc ggctgcttgt 95400 tgaacaagac gagaaccaaa gtttccgtct ccttccaata ccggaatatt gttgttccac 95460 gtgtttgcaa tcagttgccc agcacttgca gcagaacctt caccatggtg ataacctgcc 95520 tcagaaacac cacccgcgag agctgctact ttgttaaact tggtcttatt ttgcttcgca 95580 tattccaatg cgcgatacat gaaaaagcgt tgaaccggtt taaagccatc aataatagat 95640 gggattgcac gctcttcaac cgtatacatc gcaaattcaa gagcttcatt gttgatgatc 95700 gattgcagat gtcgattgtg cagattagtt aaatgacttt gcaatacggc tttcttccat 95760 gccggaatat ccgaatcaat ttcagattgg cattgccgga tttgctcttc aagtacttca 95820 gtttcatcga cttctttaac aaccgaagaa tcgagtactt cagtttcgat taccgtttca 95880 tcggtgacct ggttgatggt aattcctgcc tgaggaaaca attcatcatc tttgctttca 95940 tcccaaggcg gagtttcggg attagatgcc ggttttgcaa ccggcacaat cggctcttga 96000 tcaaaaaaat catctaaact aaatgccatg ggtattcctt atcgtttttg atattcgaaa 96060 ttatatacct taaacagttg acgcgaaaca gcagtgagcg actgatattt ggtggtgtta 96120 tcttcaaaca gctcaagttg ttgcatattc aacagtcttg gcaccaagga catcgggata 96180 tggtaaaccg tatgggtctt gttttgacct gtgactgagc gataaatctt ccgcggaaga 96240 ccgtcagtat atttccaaca gcagctaatt actcgtgaaa tagtctcgtt aaagccaaca 96300 cacttttcct gttggccaac aaaagtacga gctacagcaa caccatcttt aacgataaca 96360 taaatgccgg gcttgctaat gctttcacga ttttttccag gcgcaaaagt gaatttcaca 96420 tccaggaatt ttcctgcgtc aaattcaaaa gcaccaacac gttgggcacc agtaactaca 96480 atacgttgag cagtaagatt agttttcatg atatttttct ctattcgatt ggatttatac 96540 gtattttaaa ctgtttgtgc gaaagctgat caccaagttc cgacacaatg tcatctaact 96600 aattgatgct ggttggtttg aatttctcgt ccaatgatca gcttcattct tccacctcga 96660 tgatgcgagt gccaaggtct gctacattga atgggtacca ttgggtactc atgtaaattt 96720 cgccgtcaat ttcgatagtg tcagaacaaa cttcacgttc gatgtcttcc atttcgaaga 96780 ttgtatccca tgagtcaaaa gcgaatacaa attcttgcgc gtagttttgc ttggcccatg 96840 cgttgaattg ctcttcacta acaaaacgat acttaaccat caccaaccct ccatcgggaa 96900 ttccatgtaa acttgaactt gacgtcgaat ttcattcgac ggtgtcagaa ctcgatcagt 96960 gtcgcgagaa actcgaccaa accaacgcca tccattacta actgcctttg aaccggtgtg 97020 ccaagtttgc cagtcaaact ctacaagagt tcgatcgggt gcaatgtgtt tactcaactc 97080 gccagactca agtttagcca tgacttcctg gtgccactgc cgatagataa gttcaccgtc 97140 gggaatttgg ctgaattctg attgtcctac tgcaaaatga gtaggacaga tatcaccatt 97200 aaccaagcca aggatatggc gagacagata acgaggattg tcatagtctg gctgtcctgc 97260 ggtggcaaag tgctggccta ccggaatcgg agggcgcggc acgtcatcat gatgatatcc 97320 gggaatcgct gggtaccatc caggcataag catatgaaca cgcgaatcga aaatcacatc 97380 gcttttccaa tcaagcggga gattctcgat gaaacttcgg gtgatagggc cgccgttctc 97440 gtacgcgaat tccaggtccg agttgaaaaa cattggctcg tttttgattt catcattgga 97500 gatgaaattg gcgaaaccgc cacgaagttt gaattggctg tcgaatgttt taggaccgtt 97560 cataacttac tccaattaca ttttttcttc tttgatgagg gtgatagttg catctttgtc 97620 gcccgtttca tccagatact cgcgaagagt tttatttgcc caggctttac cgcgcttggt 97680 gccgacaaca taattgaagg cttcggtaga agtttcgcat ttgaaagtgt agttgatcat 97740 aaaatgctcc gtgtttatct atttgtttaa cttgtggcta tagtatccta tagccacgag 97800 attgtaaaca tgttttattc agaaagtgga acaaaatcaa agaaaaccca gttcacacgt 97860 catacatctc atcagaatgt acaccactta ttataaaaat aaacaaattt gttgtgctgt 97920 ctattgacgt atgctccgcc tccgcgtttg ggaacgcaga tcacatacgg ataattttcc 97980 atagctcgct tcgtgaagaa gtaattcggt ctatatgtga cgcggccagc gtattcattg 98040 atgttcaata ccaaataaac atcagcatct ccgcgcaaac cagagtacaa gcacagccct 98100 tctgatttgc catacggttt agcaccagcg gtatgcattg ttggccattt cgcaaaagaa 98160 gtctttattt ccagattgaa cccaggtgtt ggcacatcaa aggtgatatt atcattgtct 98220 aaccagtcaa atactcccca gacaccaccc aggatatatg cgacacccat ttcggcattc 98280 agtgaatgaa ccgttctatc aatgacctct tgccgaggaa tatccttccc ggccgcttca 98340 tcaagagcgt attgaatggt atcatcatat cgccttttcc gtttttcaaa aagctcatcc 98400 cttgtgtcgg gctgcttttt tagttggtcg cagatctgaa gacgaataat atccgcgtca 98460 aacggctgga tatgacgaag ggcgataaat tcatcgtgtg atacgttcat cggtactgtc 98520 attacaattt cctcacaatt tcagaatatg acaatgaaaa atcggataaa tcaaagcttt 98580 ctataagata aatgatttgt ttcattttct cgtaatcttg agcataaaac gctcgaccag 98640 cagcaatgaa atgtgtccat tctttttcga atggtcctaa ctgccaagat gttccttcaa 98700 caactgcaat tatgctcttc gctttctgca agtcattcgg cgaaatccaa ccatgatttc 98760 cataacccga accaacaatg tcatcatctt tgtaaaatac aatgctaaat ggcgagctca 98820 tacaacccct tacaaataag ccctccgaag agggcttatg aaaattagta gtgcttcatt 98880 tctttgaagt cagaagttac ttcgtaaaga acttcatacc cggcacaacg cattttggca 98940 ttgttgtaat cggttggaat agcgactaca tccgccgggt tgaccttgca cgcaatcact 99000 tttccagaac caccgccata atgagggata taagacttgg cagcaacatg aagaccatga 99060 gagcaggtaa cgttagggtt ttcatcaact tggaagcgat taaccttaac cactgttccg 99120 ggagagttat cgaatttgcc ggtgtacatg tctttgaaat tgctgcttac tcgcttccaa 99180 gcaatgaaat aaccatcatc ggtgatttcg atgtcattgt gttccaggaa gtcgtacagc 99240 tgatatacgg cccgacgact cgggtttgcc atcagatttt cgaagaatgc gaccagaggc 99300 tcgaaaggtt cgccattctg catcttctca acgatacgac gagttaggcc cgaatcgata 99360 atgaggtctt tgtatttcag ggtgccgcct tcaataatca agtcgccgga aatataacgc 99420 tcaagaccac gcttgatatt cagcatttcc attgcttcat catatttttc ttcgcgcaga 99480 agaccaatga tttccatgaa ctgtgggtga tcgccagaag cattataagt ttcggcaccg 99540 atggtcacgg acagaaactt ggagttagcc atccaggtgc attccagctt atcagcaatt 99600 ttttcatcag caggtgaatc cgctggtact gcagaaaccg aggtatccca atttcgaact 99660 tctttcagaa cccgagcaat tgtatctacc gatacacaat attcgcttgc caaataagct 99720 tgagacacac tgccagtaga atatttgtca aaaatctgtt gctttgtttc attgtcaaaa 99780 cacttaacga ttttaagctt agccatatca taccttcttt gtttaaaggg ctcttactga 99840 gcccggagaa tttcgatatc tttcatgatt tcaggagtta attctatacc actaacggca 99900 actgcaaaca atagcgggtg tttaattttc aatgattcca tgcgggcata gaacatttca 99960 gaatactttt tattctgttc atcaacgtat tctttgattt cagcataatc ggcataatcg 100020 ggatttccga tttcaaccca ttgagatgca tcattcagga aatcatcatt gctttcgtca 100080 aacttttcgg ttatatcaat tccaagaatg cccatttgct taagacgaat tgcttcttca 100140 tagtcactga tattagggca ctcggcacta agaatatcaa aagcatcttt tgacactttg 100200 cactggtcat atgcccactt aaagccgcat ttcaagccag gagcctttac agctgcagaa 100260 cgctttccat tatcgataac gtaaacttcg gttgctccaa tctgcatcaa tttgctaggg 100320 gcattacgca ccgtatacgg tgaagcttta agcgcaattc tgtcaaatgt atcgttatac 100380 gaaataaccg caattccttc aagagctttt atttcggcgg atgtcatgta aactaattcg 100440 atgtcgcgaa tgtcaaaatc attaatgtaa tgacgttgaa cgtttggctt aggatcgcga 100500 cgaggagacg ttttgcgctt atgtaccgta aatgcttttc gaatatcatc catttcgcta 100560 aatttgagaa ttgagcgttc gccaacatca aacttctcac aaatagcttt catggttcgg 100620 gcatattggg cgtactcgtt tttcttcagc ttacgagttt tgttcaacac aactatcgga 100680 atggtattgc caatatgatg atgatatgcc cgaaccatat tcggaatgcc ttcaccagta 100740 tcattgatga gaacatgcac tttgcgccga ctgatgccaa agatttctgt tgcatctata 100800 ttggaacttc tccacgaata tcccgagcgt gtaacatgct gacgcaaact gccgccacga 100860 tatgcataaa cggtaatgtc acaaagcttt gacatatttg tatatcgatc aataagatcg 100920 ttaattcgtt cgccgtcaat gatcaaatct gaaatagctt ggcgaacata gttgttgtat 100980 ccgctggctt taattacggc ttttcgttta tcggttattc cgtcaaattc cttctttacc 101040 gattcggcaa agttatcaga aaaatcacga agtcgagaaa cgatgtaatc ttcgccttct 101100 ttggtcagtg acagttcttc ccgagaagga gcaatgtcta ctgagccaat ggggcacttg 101160 atatacgcgg ctttgccagc atatcgaaat accatatcgg attccaggag acgatgaggg 101220 atcgggtaca ctactccacc gattacggca tatacttctc caggacgggc gaattcgtca 101280 gcattgaaga acgaatcttg attcggaaat tcttcaatgc tgcttgcatc catatttgtg 101340 atgtaaggct tgcagcgatc aaatgccctg tacactttgc gagctagtac tttccagcga 101400 gcgtgttcat gctcagggat tggaaccaga atctcgagac catcttcttc ggtcgtcgga 101460 gtagtcgaca tcggtgtagc aaatggttct ccattatcca tatacatgtt gtagacagta 101520 cacagacctt tttgatagct ttttaccgtg aaaccgccac ccgactcact gtatgcaaat 101580 ggagacttgc agctaagacc gaaaccgccg attgaatcat cggaaccatc tttggtggaa 101640 gcaaaataga cagtgaaaat ttcatcaact tgctcttgtg tcagcccagt tccgaaatca 101700 cggattacga accatgggta aattgaagtt gggagagtga cgttgaatgg aatatgtcct 101760 tttccgagtt cacaatggat atcaaccgca ttacacgaaa gctcgcgcaa aactgcttca 101820 gctttgtctt tataaagctt ttcagaaagt acttggaatg ccttccgccc ggcctggatt 101880 ttaaacccgg tccgtttaga aggtgcatta ccaaacatca catcttgttc gttagaacca 101940 ataatcatta tatgtttcct ttattcagta atatcgaaat attcgcgctc accccagaaa 102000 acccatgcgt gatcttcaca ctgaccaccg tcatacacaa acactccagc gacttgattg 102060 ccgaaaccgt caagaacagc caatactggg gttttgtcat attcatctgc cggttcttct 102120 cggcattccc acgtgtccat accgagagtg tgagcaatcc attcattgca tttggcaata 102180 cgtgcaaatg ctttgcgatg ttcttcggat ttaaaggtga tttgcataat tatattcctt 102240 ttttcatgcg gtgttccatt ttggaaacaa ttttgcccca atcggaacca taaagattcg 102300 cttcgtgcac aagacccaaa tgacatagcc ggccaagttc tttgcgggtt gcaataccag 102360 ctttgatatt atcaataatt gggttaactt cgtcgctcag ttcatcggca gtttcttcat 102420 cacccatgaa tcgtacattg atgcgacaaa ttcgaaccag agcttcagat atttcttcat 102480 gcagggtcat aatgacctcc tttgtttttc tactggtgtt atcctaacat agtaaacatt 102540 accatgacac agttaaagtt aaaataattt taggattaac tgggttgaac ctggataata 102600 ccttattctt atgtgaatgt attattgact aaactattga gttcagccag gtttacctgg 102660 ttcgaccctg tcgaactaac catttttatc ctttatggct taatagatat tataactaaa 102720 aggataaatt cgagcttcgc tcgaagaggc aaagcctcaa actgttttga tacaaaaagc 102780 cgggcggctg cccggccagt caatcaatca gtcaatgaac tcgaagaagc aaacttcgtc 102840 gctagcgata gactcgaaca ccatgccatc aatgacgatg tcgaaccagc cagcaaatgg 102900 agaattgagt ttgacaacgt cgaactcttt cattcccaaa tgacgagcga tgcgacggtt 102960 gttatttgtg tcgcccagag ggccaattgc ccagcgcttt tcatcgtagt tgatgaactg 103020 ctgacgtgct tcttcagatt tgaaacgtgc tttcatttta ttctcctttc gccaattcaa 103080 tttgaacgta ttcgatgtat gaagcagctt tcttgccgcc gagacgcttt gctttctttg 103140 tgcctttaat gttcatgaaa actgacggag aatcagtttc aacaccgtaa acattgataa 103200 aggtatcaag atacggggag aagaacattg catgggattt aacattgccg aatgctttgg 103260 tgaagttgat cattttaaat tactccatgt ttttgcagtt cgtttaactt gaggctatag 103320 tatcccatag cctcacgatt gtaaactgct ttgttgtgaa attattcaat aatttccatg 103380 aaataatgaa gttcttcgtc gtcgaaaatg attccgccac cacctgttga ttccggcagc 103440 tcgatcatca caccatcaga atcgaccaaa cggtattgaa catttttgtt tggatcaaac 103500 cgagccaaaa attcgtctgg catgaatttc tcgaattcgg cgttgtacga ggcagattta 103560 gcaaaagctt tacggtgctc cggggatttg aatttaactc gaacgatttt catgatgtac 103620 tccttagttg atttgatgga gccataatac cattcacttt aagcgttgta cactgttttt 103680 caaaaacaac aaagggctcc gaagagccct ttttcattgt gacatccatt gttttcgaag 103740 ttctgcttca tcgccaagca gcatttcgaa caattcttcc caatcgggcc caagatcgac 103800 gatatcatac tgagggttat taacaacttc ggaatattca tgttcgcgaa gtgaacccaa 103860 tcctttgata tatcgaagtt cccaaccttt gtacttttcc ttttgcgcat caaactcagt 103920 tatggtataa aaccacttgg tctgctttcc tttagaaaga atgactaccg gagtttttac 103980 aaatcgtacg caaccgagat catacaactt tggccaacgg ctaaagaacg cgagtagaca 104040 cgggtaaatt gagccttggc catctggatc ggcatcagtc atgattgcaa catttttgta 104100 tttgcgattt tcgacatcat ccggattagc taaatcgaga cccatgattg cacagatatc 104160 ggccaattct cggttcttta gcacgtcaga acctttcatt ccccaagtgt tcataacctt 104220 tcctcgaaga gcatatccac catgcaactc gctgtcacga acactcaaca aataaccaat 104280 ggccgaatca ccttctgtca ggaacagagt tgtttctttg gaaatgtcac cccaggaacc 104340 ggcctttata tgcttagcga ctttggtttt tgctgctgct ttttgggctt tcgtcaatgc 104400 tgctttttct gcagccagat gacgagcaag agcagcctcg atgattggca tcaggatagc 104460 atcattgttc atgatttgct ttcctaactt tttgaaatcc agctcaatgt gtgatttcac 104520 ttcaccaagc ggattcgtca aacgttcctt tgtctgagaa tcaaaccgaa gattactcat 104580 tccgcgaaca atcacaatca tcgtcaagca ttctttaatt cgagctttgc ttatttcaat 104640 tttatgcttt cgtttgattg atggaataag ttcgtcggca atgccatcta ccaagtaatc 104700 gatgtgggac ccaccattct tgatattcaa accattgaca taactgactt gacggaatcc 104760 ttcaggagaa ttgcagattg caatgctaaa attatcattt tcgagaatga gagattcatc 104820 accgaacatt ttagcgtatt ctgcaaactt catcgaagca acttcaccgt tgatagtgaa 104880 tttaatcttc gggaacacta cagacaatgc tgtgattcga tctgaaatga tatctactat 104940 ctgctgatcg atcgtttttc cttcaaagtg cttttcatca gggatgaaat ataccgacgt 105000 tcctttgatt ttacctggct tggtttccca attgacttga gatgcaccat cagagcaagt 105060 gacagtgaga aagtttttgc catcgcatgt ttcaccgata aaagtcttgg agaagaagtt 105120 tgtcagagaa gaacctacgc cattcatccc catcgatacg cgtttagtat catcaaagtt 105180 tgaacctgcc atagtttgtg tccaggcagc aacaggcttg ggcatttctc catctggagt 105240 gtttaccatc gattgaggaa tacctcggcc gttatccact accgtcacag aaccttcaag 105300 caaatcaaag cgaatatcaa tcttatttgc aaatttaaaa tcagtacgaa taccttcgtc 105360 aaccgagtta tcgatgattt cgtcgatgat ttttaccaga cccggaacat aggaaacgga 105420 ttgatactta ccaaacaaga atcgctcatg cggttcatat gcaacagaac ctacatacat 105480 atttgggcga agaattacgt gttcgcgagg agttagaact ttgaattcat cagacattaa 105540 tattcctcat aatgaattga tagagtagtg ccattatatc actacttggt gttttgcgaa 105600 ctttcgcgtt taatctttcc agaaattggc acaattttct atcggaattt gtgatcgcac 105660 taccgcagcc gaaagcatat ctttaactct tatcgggtca cattcggttt tttcaacgat 105720 tcgaatcttg cgcattacat cataaaaatc atcaaaactt atgcctttgc atcgcgtaat 105780 aacaatatca ctatcgctgt ctatccagct tcggcgaagt acataagttt tttcatgaat 105840 ctttttgtca ggttcattat aatgcggatg ccaattaaca taaacattat gccgagcaag 105900 ccactctgtt atgctgtcaa actcttttgc ctttatttca agctggccgg ttttaaatgt 105960 tcggtaaatt ccataaaagg cgaacatgag cacaataccc atagcgacaa caaacaagac 106020 agctacagtt gacatttagt cctcccaaat ggttttttta acatctttca tttgcgattt 106080 gtaaagcaaa gacgccaaat taccagtctg atctaaaatg ggatccgcaa tactgtcttt 106140 acggactttg acaagagttt tatacaattt tcgaaaaccg atgcctttac agtttgctaa 106200 atcaacattt gttccatccg cgataataac ccattttgcg aatggaccaa ttttgtttcc 106260 ttttagcctc atcgtcatgc tatacttctt tagccatgca ttcattgcag tgatttcagt 106320 ttcgcattta tttttccaat ggtcatccca catagaaacg taacatgcaa taagcacagc 106380 gctgacaaca atgataaaaa ttacttggta catgctttca tcatccattt ttcggctttc 106440 aggttgagtt gaaaattcaa ttcggtttta atcaaatcta cgatctgtgt ttcactgagc 106500 tcaggataat cttccttgta ttgcaaatac agcatgtcac aaacacagtt cataatatct 106560 gcagcttcgc cgaccggccg ctcatcacaa cgttctggct ggttcagtga cttggcaaat 106620 tcacctactt cttccatcaa cttgcccatc acaaaaccca tcgatcttgg aggaacagcc 106680 atgctggcgt taaagctgct agtcatatcg attttgacgt catcaatcat ttttgctcct 106740 caaattcaaa atatcgctgt tcctcgagtg gaattccaat gtggtatcca aggaaagtag 106800 catttgtttt caatgtcccg tctggcattg tttcgagaac ttcgagttct ccagatttgg 106860 atttcagttc aagcgtactt gcccataacc tctgcccttc cgttttgcaa aaacgctgtt 106920 gatattcgga aagagggatt ttcaatttaa ttttcatttt gaacctcgaa atattgcttg 106980 cagtttgcag aaattctgcc gcgccagcat ggaccgtaga cattgagaag ccattcgggg 107040 ccatcattgc ctataacaca gagttgcctc cattttgcaa attcaacaat agtccttgcc 107100 aatctgtaag attgactgtc ttggcggttt gcatctatga aacctttctt atcaacaaga 107160 cgaattctca ttttattgct cgtattgaag tttcactaaa attcgttgtc cacgtttcat 107220 ggaaacatcg acaattcccc tcaaaccaat cagctcgtat gcatacgtga cagattgcgg 107280 aaaattagtc gcaatgattt tgcgaatttt ctctttatac tcagccattt gagcttgaga 107340 ctcattgtat gccttagtct taaagagttt gccccaagtg tcttgattgt ttgcaccaat 107400 agagttcatt tcaatgaaaa ggtcatacaa ttccttttca actccatgac ttttttcttc 107460 gcacagcagc aatctatgat tcggagctcc cattagattt tacccttcag ttcttcatag 107520 ataccttctt tcagcaccca ggtggtacct tctgcggtga taacccgttc gagaacagca 107580 attcgagtat tgccttcgaa aacatacaga acagtggtat agcaaagatg ctcttcgtga 107640 gatttctcga caacagaaac cttgttggaa aacattacgt caaggaagaa atctttggaa 107700 atacgcattt tcattactcc atgtttgttt gatgtggcca ttataaaaca gccacatcag 107760 ttgtacactt aaatttcgta ctcagagata aattcaacaa aatctttttc tacacgaacg 107820 ttggtctgtt cgagttcgca aatgatagca tcgccatctt gcttgacgtg atactcgtaa 107880 ccgacagcct gaggatccat agtagcatac atatcatcag cacacgagaa aacttgacag 107940 cctctagaag caatcgaata agcacaaatg ttggcttcaa ttgcaaatgc tacaccgaat 108000 ttgttaattg tgtaaatcat aaaaagtact ccttgttgtt taacttgaag ctattttatc 108060 atgaagcact atcttgtaca ctagttttgt aaaaacaaca aggggctccg aagagcccct 108120 atataaatca gatgaaacga taaactggat tcgtgcaagc acgacgggcg aagcccggtt 108180 ctttttattc cagttaatca ctcagttgtt ttatcaattc aactgacttt ttatttatgc 108240 tgtttcccag gtgactctcg gacgtgacca cccagtgtca cagaatgaag tctgcctctt 108300 ccaaatatga ttcattgaga ccaccttgga tatgaaccag gtgcctaagt aggacctcat 108360 catggtcatg catgcacttg gcgtcatcca agaccaccca tctatggata ttatgatcgg 108420 ccacatgacg aagaacaccg gtgccacgag attttccacc gccagtatcg tatgcttctg 108480 aatgatatgg aagttcgaga aaatcacata tcatttttcc agtatcacgc aaaacgaccc 108540 acgagctaat tataaccact ttagcatcat gtttctttac ccattccctt agcaaactga 108600 gtctatggtt gctgacaaaa tcgccacgat tgtatggtga aacgcgatac aagtgactgt 108660 tccggtcagt tctccattcc gtgtgatcat cactcgtatt gagaacacca tcaatatcca 108720 gataaacaac tacctcttca tttacttgct gatccatttt gggcctcgtt tggttcgttg 108780 aatccatcgg aaatcagtgt tgattacgcg gttcaaaaca tgatgggtcg ctgattttga 108840 tagccaaaac tgaaacttca gttttcgagt gtctcgactt ctgataaaaa gctcatcagc 108900 cccagacaag cagccgtaaa tcaatctgtc atgatcataa acggcaactt cgcgaccctt 108960 gaggaagcag tgtcgtgcga ctcgcaaaat agcacaaaaa tcttcagttg aaatgaattt 109020 tgcaaagtgc gggttattgt tagcaaacgt aaatccacga gtgccatatt tgcaaccatt 109080 tgctggaacc aagccgaagt gatatgctag ccaagcgtaa ttttgtttca ttctcgaatc 109140 tccactagta caccatccct gaaaggattt ggttttgcta cccaagtttt ggccgtcgga 109200 tgcttttgcc caagcatttc accgatagat ttaatcaacg cttcatatcg cgcattataa 109260 tcttttcgtt tgacaaaccg cagaaacatc gttgaattca accgatttcg gatttccatt 109320 gctgtttgga tcgttgtacc ccagaagcta tctgcgtcgt aatgctcgta aatcattctg 109380 atacctcatt tttagcccat tcaatgatta cattgtaatc accactaaca aacgcctgag 109440 gaacatctat tgcaatttgg aattcttcca ttggagaatt aacatcacct tcgacacaca 109500 aaactccatt aaccctgtta aattcccatg ccccgttaat aacataagca ctttgaattt 109560 tgtcatctcg ccaggtgatg tgcgataaaa gaaggggttt tttcaacccc tctccgaaaa 109620 caactatcat ttacggacac tccgcgggtc aacatcatca ccagtgggaa tatcgtcgag 109680 accgagagca tatcgcttgg aataaagcaa ttctagcgca gccttggcac aatcgtgaat 109740 tgcgttatga gcaacaaatc catccaaaac acccttcggc atagggcaca tggtcatatc 109800 tcgcatcagc agagtagctt ctacagcagt acgaacatcg cgttgctgcc agaagaaaca 109860 tggctcgtat ttgaatgttt cacgggtgtt gtaaattttg cggataacat cgatcataat 109920 aggaaaatcg aagctttgac cgcgacacca gccctgacct gttttcttgt caaacccttg 109980 tgccgcaaga aaatcaagga agctttcata aaattccatg acactgacat cttcgttcga 110040 cggtttaaga tgcttttgag cttcggcgtc ttgttttttc caccaatcga tagtgccttg 110100 gtcaaagaat ctcatgcctt tttgttcttg gagattgaat ttgaatcgac gcccacgttt 110160 acacagatct tcaaacgtag gcagtttgta cgggtcatgc tcaaacacta aaacagcaag 110220 gtcaactact gcaccgtcag gagcattgcc catagtttcc cagtcaataa taaaatctgt 110280 cactttgctc atactaatct actctccact tggttcggtt taatgtgcaa taccatatca 110340 aaagcatcac tcaatatgcg ataacctccg aatttgtatt gtaatacggt tccgctatag 110400 cgatacccgt ttttgataaa atagaccagt tgacctggtc tataaatcgc tttttcagga 110460 tacttatacg aaacagacat ttttgcgggc acgagtattt ccgacataaa tcaattcctg 110520 tgcaacatcc gggtctctgc aatattgatg caaacacgga gtaaaaagat atgcattatc 110580 gaatgttgaa ccctgtgatt tatgaaatgt cattgcaccc aagggtcgaa ctttggtgaa 110640 agtattgcgt attgcccaga agtctttcca gttggggaaa acttcacgac ttctatattt 110700 ttcagcaata atagacaaaa attcgtttat tgcatattga gtattttggt catgaacaac 110760 cgtaaaccac gcccgtctat agtcatcttc atcttcttca taagattcac actcgagcat 110820 tgtgcattcg acttcaattt cgccgacacc ttttgcttta agcgttttgc gagaaggttt 110880 gacgtttata acccgtacgt tttgtccatt gttgaaaatg acttctttta gagtttggcc 110940 accaatgtct atgtcaaaca tgagtggttc ttgcatgacc agtatttcat ccggtaagaa 111000 tggcgcagcg tttgctccat gcagctgttt gcggataacg gaatttagct tatcaacaga 111060 attgtttgtg taagccatta tgcgattttc aagtaggtca ttaggcgttt ttgttctttc 111120 gaaatatttt gaaagaaaat ctttgaccgt atgaaattgc tttactccat tgccagaatc 111180 gtcaagcttt tcataaatcc atttgccatt tcggatatct gttgcaactt caatgattgg 111240 gccttggtga cgctttactt cggtcaattc aacttgttca aatcgattgt ccgtaaagaa 111300 tggactgagt tcatgcgtat catcttctga tactccccga atttgcgcct tatctccaat 111360 gccgacaaca acacaatgag atggaacatt tcgcatcaga atgtcaaaca atttgcgggt 111420 ataaaacgac acttcgtcac agataagcac gcgtgttttg gagaagtcag gagtaccttt 111480 ctgctcaaaa atttgatttt cttcaagagt gcttgggtta atcttcaaga cagactgaat 111540 tgtatatgac ttacgcaagg catgcttgga caattctttc tttgcttggt gtgtaggtgc 111600 tgtgagaaca ataccttgtt ggccggtctg gaaaagacgt tcaagcaaaa aacgggtcat 111660 agtagtttta ccagagcccg caggccctcg aatggtaata tggcgtttag ttctcattgc 111720 ttggagtgct ttttcaatag catctttttg gccaacagtc aaatcatcat atgttaccat 111780 ttttacctca tttgttttgg catcacatta atatcaacga tatgcattgt atcacacatt 111840 cgtttatgcg tattggccaa atattccgac ggcttgttga ttgcgactat cattggaggc 111900 ccaaatagtc gttttttgac gacttttgtt cctttcaaat actctgctat ggcttctttc 111960 gctttctgca cattagcttc ggcatcttcc catgagttat ggaatacaac gccgccgaat 112020 gagccataca aattgccatc caaaaaatgg cagaatcctt cgacgtcttt ccattggatt 112080 acatattttt tcatgaatca cccgtggcag aaaatatatc catttccatt gggattattg 112140 acaactttta tatcgggaat gaacgtcata tcaaactttt ctgatttaaa agtgtaatta 112200 acccggatta gaacaccgtt gggtgtattc atagcaaatg ttacgccatg attgtccctg 112260 ttaatttcaa tccatttgac ttcgtacata acaaaaatcc tcatatttga ttgtttgaaa 112320 tggaatatat ggggcgtaaa tagacgccct tccttcttca acatctagtt tgcgcaagcg 112380 attgatttca tcaatttcat cttgttcaag cattagtatc cattctcctg ccttgcgaag 112440 ttttcggcat ttttcaaata atagagtttg aagatttcat cgccatccat gcccatcgca 112500 atgatcttgt taagaacaaa atgcatttgg tcaatcaact caaattttgc ttcgagttgg 112560 tcttcaggcg acaattcaga aaatagtcga ttacgatatt catcgtgttc ggcacgccaa 112620 ggtttccaga tcgcattcgg tttggggtta ctcattccac ccagagcagt ataatgctcg 112680 cgaatttcgt cggcaatata atcgtcctga gcttgacacc agtcaagaat ttcgccacaa 112740 gtcttaagct ctcgcgggtc gcgattgtat tttgggtgcc gttgtgcgag ctcaatttga 112800 agttgacgct gcatatcaat cattcgattg agaggattct cgttggcaat aaggcaatca 112860 tacagcgcat ttactgcctt atccatatta ccagttagtt gtgcgcattc attgaattgg 112920 ggtgtcattt tgttctccta tgttaattgt agtaattata tcacttttcg acacagacag 112980 cagtattacc acgtcgttcc tattgccata gcttcgcaga cttgacgact tttttgaata 113040 ttcattttca aattatcgat ggtcatattg ataaaaccag tttcgatttt atactctaca 113100 gatttgaatt cattaattag accagctgaa cgagcttgag ctacccatct gcccatcaca 113160 tcgttgcgaa ctatcctgta cgcgcagtcg cgcatccaaa tcggagcatt tttgtcacgg 113220 taatctgtgt agctcgtttt tccgcgaaag ttgagttcat ccccttgttt tgcttgccaa 113280 atgagatctg ccaccgtgtc tttttcgaca ggccgtctgc ttgtagcttt acttgtagct 113340 ttagcagaat cggttcggac aatttcagaa tgtggttttt tctgaacacc ttccaattca 113400 gcaataatct gcaactcaat gatgcggtca gtcatattgt cttttagttc agacaatgac 113460 gttgaagcat tccgggtttt gatatacgca cgctggtcaa ctttaacctc ggggatatgc 113520 gataccgcct taaatgcttc tgccatttga tcatccagca aagaaatttc tggaacagcg 113580 caaatagctt tctcgatagc attcagattt tttacttggc aatcgaagct agcagcagaa 113640 gctgtagaag cagcaaataa tagggcaata gccatagctt tcatgttttg ttctccatat 113700 tttgcatatc gcggacagcc gccagagcac cgcggtcgaa atcgttaaaa tcgaaagaat 113760 tatctgcttg cgcttcaatt tcttcaagag attgagtttt tgcggcgtca aaagcccact 113820 tatatccgcg tttataaagc tcagatttca ttcatttttt ccttatattc gtcaatctgc 113880 ttaagttgct gaatttgttt ttcagtcaac ttatgctttt cgggaatcat ctcagaaatt 113940 cttgtgcgac tcagcgagat gtcagctttt gacggttccc attcaccaaa caaatgagcg 114000 tattcaggga agaaaatttc aactttccaa ttgtcagtcg ccgaatagcc gcgctttgtc 114060 atttcttcca ttagcatcag atatcgatcg cgcagccaag ccaatttgtt gtaaaagaaa 114120 gttacatgcc ctcgaccacc gagagggttt ttatttgtgc gaacggtaaa ttttgatgga 114180 attttaccag tctttccgtt tttcttgatc aaaatgctcg caacccgagg attctcatac 114240 cattcgccta tgaggtgagc attgcacaat agagaaggat gttcgagatt tatacgtgtc 114300 atagcgttca aatcaccatt ttgttaactt gtgattcttc tgcgatcata atcacagtgt 114360 aaaactatta aattccagaa aataccataa gagcgaaaat gaaatcgttg tgaactttga 114420 acagtgatgg ttgagtatca gcaatattgt tcaaaacaca acgaagagtt tgacgttcag 114480 catcactcat tttaccaccg ttgatcgcat cttccaaagt atcacgaaaa tgaccttttt 114540 ccatagtttc gagaatttgg aaaccagatt tcttttcgtt ttcggtgagg ttgagaacgt 114600 tagtttggat agtcatgata tactccgttg ttttaatcag tttgtttggt atgatgctat 114660 agtatcatct ttagagatag tgtacactgt tttgttcgtc atcgttcaat aaaaacaact 114720 aaggcctccg aagaggcctt agcaacgctt ccatttgccg aatcgcagtt ttgcttgcaa 114780 acccgacacg acgttgtcct tgcaatactg gagaatatct tcggcagttg cattttcctt 114840 cattatcata tcgtttacgt cttttgacgc ccaagcgcac ctgtcccaca tcacaactcg 114900 ttcacctgca tctattagcc tagacagccg cttgcatgta tcaggatgaa atggttcatt 114960 atcaagaacc catactcgag tgcttttgaa cggcacctcg gttagtgcaa gactaccgcc 115020 agtgatagct ccagaattcg gaatgaagag ggagtcaatt ggtccttcca taaaccatac 115080 agttcggtcc ccatcaattg tgtccattcc gtaaattttt gatgcatctt catgagcctt 115140 tatagtgatg tatttgtttg gactagctga tagagctctt ccctgaaaag actggatttc 115200 accatttttg tcaaatattg ggataaccaa tctattttcc ggcgattcgc gtgtatacgt 115260 atctggtgaa atagaattta ccaatttttg ccattcacga gtaaaccaca acctcttgta 115320 tgctgattct ggtatttttc tgtttgcgac atattttact atagggtggt tcgctggtag 115380 caaatctaga cgatcacaaa aatttaactt ttcaatcacc ggcatctttt tggtgaagag 115440 attttctact ggttttgctt ctggcttgaa gacagtgctt tctttccttc tttctaatag 115500 ccattcacga taaagttctt cttctcgctc ctttaaatac ccgcccaaat tgctatgata 115560 accacagtta aagcaatgaa cttgccactc gcccttcttc tcatacatcc aaaagcgggc 115620 tttgttcatg tccgtcatgg aatcaccaca tattggacat cttgaattga actttccctt 115680 ctttcgtttg aattttggca aatgcatcat tgctcgttca gcaaacaaaa aatcagcaaa 115740 cataataact ccaaacgggg ctcttggccc cattatacta cgacaaaaat ccattagcat 115800 ccaattgccg acatgcttcc aacagaattt cacggtgttg agcatattct aaacgagaga 115860 atggctttcc ttgcgtaacc aagtacgaat caatttctgc agcattaaca gccatctcat 115920 acacgacatc cctcatcatt ctcggtaaac aattcgtgta gactgttttc agaatattga 115980 gatgaggctg atttctaaga ttctttaatg ccacatgacc taaagcctca catgcttctt 116040 gagcggcttc gaacgtaatc atttcttctt cttttccttc ttaggaaggg ctttaggccc 116100 aggggaaatg actgcgccag acgttttacc agctgcaatg tcgacagggt ctcctccaga 116160 atcaccagcc acaacatctt cgtcaacctg tatatccata ttgacatgat ctttctgttt 116220 accagaacac tctagaaatg ttttcatcat cagtttccta tatagatggc cgttaggcca 116280 tcagaaatgc attgtagcgg caagttcgtc aagatgttgt cttgagttat ttcccttcgt 116340 attgtcagct tgtctcggag aaggcgtatt tggcgttccc ggccttgatt gttcttcttc 116400 tacatcatac catctctggt tgcccttttt aacacccatt ttgaatttgt taatccaatt 116460 tttatctcca taccgcgatt ttatctgctt catcaattgg agacccattt gagctaactc 116520 ttcggtttcc atcactgcga gcataaaatc agcagttgct ggtaagccag cagattcagc 116580 tacatcagac atgtcgatgt cggtcgaatc ccatgcagat cgagtagttt gagcaccagt 116640 ccatagaaca acttgatgct ggacagcaag accacgtaat tcttcggcaa tagcttttac 116700 caaagtgtac gagttctcag aacctccacg aattcgtgtg gacgcgcaga tacccaaata 116760 gtccacaata acaacatctg ctttgaagtt tttcttcagc ttcagctcgt tcaaaaacgc 116820 attgaaatga ttagcatttg caccagaagt tggatattgc ttgataatca aacgacccat 116880 atttctggat ttcagacgct ccatccgagc tttatactcg gcaaagctca tgttgccatc 116940 atctatttcg tcaagtgtga catcgagcaa gttggcatct atacgtttgg caacaacatg 117000 ttcagccatc tccatcgaga aataaacgac gtttttgcca gtttggagat aatctgcggc 117060 caaagagcaa aggccaagag atttaccaac gttgacaccc gccatgataa cgtttagcgt 117120 gccaagttct gctccaccct tggttatttt attcagaaca tttgagatga acgggacttt 117180 attcgctttg gattgataaa gcatgtaacg tcgttcataa tcttcaaacc aatcatgtcc 117240 gactgagcca tcaaacgaaa tagccaatgc ttctttcatc aaatcttcga ttgcaccaac 117300 atccggcaat ttcttatttc gttcttcgaa tggtttggct gcattttcct gtatctcgat 117360 tgccttagac aacgcgttat acatcgcttg gtctttgcag taagattcag tttctttaat 117420 caaccaggca tgatcttctg gtttagaaga cagacgagcc aaaacttcct tcacaccgtc 117480 atgagttact tgatcgatag attttttgtc aagtgcaatt gcaagtgcag ttttggttgg 117540 gattgtattg tactcattca catgtttttg aatgagttta aaaatctcgc ggtaaggccc 117600 acggtcgaaa taatcttctt ttatgtacgg gtacgccgaa ataaagtacg tattgttgaa 117660 gagaaggttc tccaatattg tttctggcat catgatttat tctccggcgg aacaaagcct 117720 ttttcggcaa attctttaac tagattttgt aactcatttc gggtgtaatt atatatcgaa 117780 ttcgttgaca gccaactaga aaatttaacc tttttgagtt tacccgattc aacccagaga 117840 ttatagagat cttctttttc gctattccat ctcgcaccgg tgcgctgatg tgtcaaccca 117900 gtaaaagcaa ttgacatatt acgcttagcc tcatccgatc ttttaagacc tttaagagct 117960 aaactcattt tagctctaga ttcagctgta tgtttactac cataccgagg attatttgac 118020 cccctagatc taattgttcc agtgttgtgg tgcaattctc ctcgatagtt cagcgtagct 118080 tcagccaaaa tgcttttgag ttcatcgcaa tcaaagtcct tcctggttga ttgggttcct 118140 ttcaggttca ctatagcgct aatgccggcc cacgctttag ggtcatttgt tgctctcgct 118200 aatgccagat gagctcggca atgatcaata tacgacaact tagccttatt ccatgggtat 118260 atttcgaatg attcaaattc gatgaagatt gacgttggta aaatatgatg ccattcgcca 118320 ttgcaatcgt atctgccgca tatagtgaga tactcatcta tcagagtttc atctacgtta 118380 tatcttgtca aaagatgttc tttagcgata accagattcg tttccaccac ggctcatttt 118440 cctctttttc tttgtcttct ttcataattt ggttaatctg agcattcata gcttcatgaa 118500 caagttgatg aatttcatca ttttcattaa ctgctttgta atctacatgc agttttccat 118560 catgtatatg agcatcaaaa atataaacaa ggtgtgattt gcccgattta tcgattatca 118620 gcagctcttg tttaacgttt tccattgcat gctgtataag agcatgagcg tcatttaagt 118680 ttttgggagt ttcatcatca gttgtagatg tcataaatgt tcccttcgtg tggtgacatt 118740 atatcaaccc tataaagatt ctaaacatag cgagcataat attgctcgct atgttgaaat 118800 tgagaattat tgagcaatat attgctcaat taggccaaaa tgtctttcat acacgtggag 118860 cgagtccgca acccagtaga tatcaccctt ttctaccatg atttcatggg attgaagagt 118920 atcaaccagt ctagacaaaa cataatcctg ccacgcccaa tcattccgat aaccgaaaat 118980 agcgtcattt gacctcatat gaacgactgc attcagtttt ccatcccgaa tctggtattg 119040 gacgttattg gtgcacatga aatcggacat accatttgca ttgtaatcag tatgcataga 119100 cggtcgagta taaatcatgt ttgcacgacg agtgtatgga ttttcaatta gatgtttgac 119160 aacatttgca aactgatttc cattttcttc gctgaaaata gcccagccat aattggagtt 119220 gatcataccg ttacaatctg caacagcttc ccaaattgct ggggttttac ctggaatatc 119280 agcaacataa cgagattgac tcaaatacca agacaactct cgctcaatat aatcgtgatt 119340 aagtttaccg aaaattagat cttcatcggc cttaaacata actggggcaa tttcgacagt 119400 tttaaccccg gatttgtcag taacaaattc atttgatttg tattttgaca ccatgatgtc 119460 acgaatatct tgaacagtca tataacgcat actatttcct caaatatcaa acatgtcaaa 119520 caaattattc ctaaattcat aatctgtttt cgtagcttca caaattgaag caagtggttt 119580 aacgaatgtt ttatcaaaaa gcttatttat atccataaac ttcaaaacat cagcttctac 119640 gacaggcgga atttgcgttc ctgacggcca cgcaaaacac gcttcattga atgggttgcg 119700 atcacgaaga ggaataacca ttaccttttc gccttcaaca atctctggaa ttgattggtc 119760 agtttttgca atccggttat atgcaagggc tcctttcaca tgatatggag ctcctttaat 119820 tggatatcct gccgaatccg cgtttttggc gatattattc gcagaagaca ctgcggcaat 119880 ctcttgataa tcgatcgttt tgaattcatt cttgaattga atgaaataat tttgcaaaga 119940 agattcacct tcttgcagca accgacgaat tgactctttt agcgattttt gacaagccaa 120000 aggagtggat gatcgttgag tttccaaacc catgatttta agatgtggtt ctgcatatcg 120060 agtgccttcc atgtcgtaga cattcagtgc atatcttttc ttaccagtcc agaacccgcc 120120 aatcccatcc gaaccaagtg gagctccaaa tatggcctca cgatccatta acaacaaatg 120180 gtgatcatta ttcatatatt tttcaagttc tttataggac tcgtcaatat atggttcaag 120240 cctcttttga cccaagttgt ccaaaaagtc aatcaagtga ttggtatctt taaatttttc 120300 aattcctact ttattgacaa ctgcttccat attgagatac accgaatcgg tatcaatata 120360 gcagacataa tcaacaccgg ttgttttgac taaatcgttg atgtattcgt ttagttttcg 120420 ttcaatccac cgaatggcta attgaccgta agtcgtaatt gcttcagcgt tacgcaagtc 120480 ataaaatctg aagaagttat taccaagagc accataaaga gagttaatca aaatctttcg 120540 gtttaattgg ttagtgtttc gtttttgctc ttctttttca catctagcta ttactagttc 120600 cagttcttcg ttggaaagag tattgagata ttttatctca tcatctgtga aatcacggta 120660 aagttctagt tccattataa tccctctatc acacaggact attttatcat aatcctgtgt 120720 gatgttaatc aatgctctga tttaattcca cgagaagcca gaattttctt aattgcttcc 120780 tgatttcgaa ttgcagctag catcatcttt ttctcagatt tacgctggag aaatactttt 120840 tcagtttcag ttggcagtac cccggtgact cctttcttat acatcatacc gttcggtgcg 120900 caactgaatt catctgaggg tttaggagca acgccagata tatagtcttc aatccttgca 120960 ggagaaaaca tccctgcgat catctcagga ctaatgttca acaatctgag gatagatgga 121020 tacaaagatg ttaagtcaaa gctcatgcca tatcgatacg caccaggaac aggttctttt 121080 acgtatgctc cagggaaact ttgctttgga ctagctttca tcattggaat aactacattt 121140 ttctcaacaa gcgaattgaa aatgatagaa tcccaaactt tgatagttcc tagtacatcc 121200 tcgaaacgaa ttttcgcgta atagcaaaga gacagaataa gatcaataaa gcatcgacgg 121260 ccatcgatca acagaataat atccgtatct cgcacgcagt aatcgacata tcgctggtga 121320 tctgctgctc ggaacttatt gattgggcca tcatattcca atttgtctgc tttaacttca 121380 cggtatccga cattgcccaa tttatagtca ggcataacag tgaaactgaa ctttttgaaa 121440 acatccatat aatccattag tgcaacacca tggatacgat agatcgtttt ttcaccgtac 121500 atatttgtaa ttgtttttga gctgatcttg ccgtatgggc ttaattggtt agctgcactt 121560 tcacccaaga tgttgataat tcgagtgata atgtacggaa tatcgaaacc ttcgctgttc 121620 caaccaaaca ccaaatcagg ggtagatgat ttccatagtt gaatatagtt gagaagaaga 121680 tcaatttcag tgtcgaatgg catgtaaacg acattgtcaa gaatatattt gtccagaaca 121740 gacttagatg ggtcccaatg gcctacatct ttaacaaggt caaaaatgta atatgctttt 121800 tgccctcgtg caaacgcaca tgggaaatca tatcaatttc atattttgca aatttgggat 121860 cagggaattc tggagctgtt acttcgatat cgactacatc gataatgaca ttgtcacgat 121920 caaaatcaat aactccgcga taattatcgg agatgtagga aatgcaatag tcgtccatac 121980 ccatggcgtc ttggccaatt tcggccattc gtttctgcca ttgctttgct tcccaaatgt 122040 tttcatgctt cttcggtacg caaaaacgtc catagatgtc tttgtgcttt gtctctacac 122100 ctggagcggc atgatgaaag agtgtcggct gatagttcgt ttttcgcgat agtcttacac 122160 cgtctttaac gtaacgctca aaaacggtat ttccaataac ttcgatgttc gtgtaatgct 122220 gcataatata tccttctaaa tggcctctgt tgaggccatt tcattaacca aatttatact 122280 tcgcgataag ctgccattca cacttttgct tgtggctaat aactctaaaa ttattgtgag 122340 ttgacaattc aataggagtt agtattttac acaaattcca tgactgaagc aacgaagcaa 122400 tattatttcg tctagaaata tcttcttcgg aaattgatac tggtagacca tctagtttca 122460 gcatttcctt gaaatgaaca atgaaatatt tgccttgctt ttgaagaata tggcagcttt 122520 gataaagttt cttttcttta ttagaagcaa tgccaattcg tgtaagtgtt tcagcaattt 122580 tcagaaaatc atcaggatga ttgatatcga tttggatcat aagaaaacct tagaattttt 122640 tagccaactt aagcatctgc gtttgatctt ttgctgtttt cgcaacagtt ttaacaaatg 122700 ctggagttac aataaatttg tgatttttca gaaaatcatt caaagtgttt cgcctttgca 122760 tgatttgcat atacatcttt gcggtatgca aatcaacgtt attcgctgct tgtataacgg 122820 caatataaag cttttcgttg attgattcat ctagtttagg ccatttgccg taaatcttgc 122880 cttttcttac agatgacacc aggtaattgt attgcgcttg ggccggcaat gctgacagaa 122940 gattcatgac gtatgccgaa tacagtgttt cggcatgcat cgaaagagca ttattgataa 123000 accatgccgg ataatcacta tttgatacac atctttccgt tttggtgtaa gtgatatcat 123060 ccaacaatgc gaatgcattg ttttcggcag gttctttgaa cgaatcagct aatgctgata 123120 cggcatccca atctttcgat ttccaagcaa tttcgtgctc attgagttgc tcatcatcac 123180 ccataaggaa attcaaattc atatcgaact ccttacagcc agttaccatg gaattctacg 123240 gcaagctgaa cgaacatata ttgaacatga atctcgatat ttgcggcttg gccaaacagt 123300 tggttgtttt caccgataat ttcgtacatg cgaatttttg ccggaccatt aacgagcggg 123360 tacaatgcat tacatagacg ttcaacaaaa ccagcgtaat cagtcgtgta ttgaccagcc 123420 attgcacgaa gcgatttcaa atctttagct ttaagtgcat caatgacttg ttcgatatcg 123480 ttgcgggtat tgagaaccag actcagaata ccgctgtcaa ttttaccttc ggatgcatag 123540 aaatccatct cgttgacagt tttacggaaa tcagggaagt tctttttaac caaagcggca 123600 ataactttgc gatcttcaac ttcgatattt tcagcatcac aaattgcttc ggcacgaaca 123660 atcatctgtt tcatcatatt gactttatca gattgatcgg ctttaccaaa ttgaataaca 123720 cgacaccgtg attgaagtgc tggaataatt ccacccaaat cattcgcagt aatgataaat 123780 gtgcaatttt tggaatgagc ttccatgaat gagcgaagat gacgctgaga atctgcaaga 123840 cctgctcgat caaattcatc gatgataatt acttttccac ctgctgccat agttttagag 123900 cttgcaaatg gagtcataac atcgcgaaca aaatcaattt ttgcgtctgc gccgttaacg 123960 aacagaaact cggcttcaac ttctgatacc agagctttgg cgacggtagt tttacctgtg 124020 cctggggaag gagaatgaag aataatgttg gggatacgac cagatttgac gatagatttg 124080 aaaatctttt tgtcatattc tggcaaaatg cattcatcga ttgttcctgg acgatatttg 124140 ttttcaaaca tgaattcgcc ggcattaact gtcaacatat taaaattcct ctcaaaagaa 124200 agcgggcttt tacacccgca ttatatcaca ccaggattta ttagaagtcg tgctttgaag 124260 atgtttcaag gacaaatacg tatgcagtat tgattccttg gaattgagca gcgcccttag 124320 aagaaatatt gattttgtaa tcggcaataa cgacactgac gttttcaagg ttgataacga 124380 agctgaagtt gttggtgcct tcatacggac agactgtcaa agaatatcgg gttcgtgcat 124440 tatcaccgtc ttcgactgca aatgcatcaa taacgatatg gtcattgcga ttagtaatcg 124500 cgatgcggtc tgcaccaacg gctcgagaga ttttgagaat ttctgctaaa tcttcggctt 124560 tcaggtcaaa ctctacatca gccggtggca tacgcagccg ttgcttcgga accacgatga 124620 ctgaagattc agcatcaggc agatttactt ttgcacgacc attttggatg acaatttccc 124680 cgtttgagag attgatttca gaaccttcac ccagttgacc aagaattgac aggaagttag 124740 gaaggtcata gatgttcagc tcggaatcaa tttcatcagc gattgtagct tcagcgtatg 124800 caacaccatt taccgacttg gtcatgatga aattaccagg ggtaagtcgc agagatgggt 124860 tgatagctgc aaaattcttc attacggaca gagtttcttt tgtaagtttc atttcatatt 124920 cctttcagta tttgaaatat tataacacaa ctacgatata gcttattagt aatctgccat 124980 gactgtctga gcagcttgaa taatcaattc gtcagtgtcg tattggaact gtttggccag 125040 tacttttttg tcattcattc ctttaacgtg atatccgcca ttggccagaa tgctttctcg 125100 acggcgtacg agcaaatcgg tatacacgtc tcgaaccatt ttgtcgattt cggcatatag 125160 ctcgaaccga attttctgct caagagcttg caattggttt gcacgaatat cgctgataaa 125220 tgatacccag gcttttcgga ttttaacaga attttcaaac acgttatcgc tcatcgggcg 125280 gatatcggct ggtacgaaaa caacggcttg attacgcata catattcctc agtgtgttta 125340 taacgaacat tctaatataa tttctactca tgcaaatcat tagtcgaaaa tttcaactaa 125400 attgtaataa gcatggcgat ttgatttcaa cttgcggata tcttcttcac tgaagacctg 125460 tttcaggtcg tcatccgtga cgaccaaatt aacgtgacca tattcatcgg tcaaattata 125520 actccttatt tcaggagcag ctgttggaag attataaaac atcaaaaatt acctcattca 125580 ttacgctagt tctccctagc tttgacatta tgatgtgtct gtcaaatttc tgaggatcgt 125640 gttctccatg cgaaatgata aacacgttgg ctttcatgtt ttctatgatt gaaaacaccg 125700 agcgttgcgc atcatcatca gaaggaccgt caaatacttc atccataaac agcgcattaa 125760 catctacacc agaaacttcg gatgctaaat cacgccaagc aaacatgaca gccatgtcaa 125820 tacgagcttt ttcgccttga gaaaaactgt tataactgaa tgtgcttctt cctgaagatt 125880 ttattacttc tttaaattcg gaatcaagag taaatccaaa atctgcatcc attatatcaa 125940 gataatgaga gatgcgatta ttgaaatacg gaatatagcg ggccatgatg acggctttaa 126000 ttcccgaatc cttcaaaaga tcagctatca aagacctacg gtgcttctct ttttctaaat 126060 cagacttagc actaattttt agacgtaggt tattcccgag ttggtcgatt tccgatgtgt 126120 aatctgttct ttcatcttgc agacgctcga ttgcagcttt tgcagctttt gcttggttaa 126180 cataaagagc aatagactgt ttttcgttgt ttaacttatt ctgaagatcg cggaaattaa 126240 cagctgcttc attgaactct atcatttttt ggttgagttc atttatgcga atatcggctt 126300 tatcaagttg accttggatc tgcgacattt tatcacgcaa tttcactagc agttcaggat 126360 cgtcaaattg ctgcatgcat gttgggcacg ttccaccatc ttcatgcata tgagcaatac 126420 cggaaaattg ttcatgttgc gctgcggctt ttgctctagc cattgtaaac ttgccaagat 126480 cggatgcagg ggattcaggc atcacgaatt ctgtaatttg cgttgtgagc aaatcaatag 126540 ccgacttgat ttcttttgct ttttcgcgag cagtgtcata tactgcctga tggtcggata 126600 tagcagcagc attggatgca ttagagttat tctggtgatc ctggtatgtt ttcagctgtg 126660 agtttatatg gtttatttcc atatcaactg aagtgatatc ctggtttaac tctttaatcc 126720 tggctttatt gattttatcc atttgagcta agacggatac ttccagcaaa tcttccacca 126780 gtttgcgcct ttctggcgct tttagttgca taaacggcgt atatccagca gtgcccaaaa 126840 caactatctg tttaaaactg gtagaattca ttccaatcat ttcttcgaaa tatgactgaa 126900 aatctttaac tgatgctgca gcatctatag ccacaccgtc acaagttatc gaaaacttat 126960 taggcttaat tccacgtgta atgtgataaa ccttttcttc gtattccagc caaagttcca 127020 ctaacaaatt tttgccagtg ttttcattca gcagttggtt ttttgtaata tctcgaaaag 127080 gtttaccgaa taacgcaaaa taaattgcct ccagcattgt cgattttccg gcaccatttt 127140 taccggtaca caatgtttta gcatatttgt taagcgacat atcgatagga tcatcgccta 127200 cagacatgat gtttttataa cgaactcgaa taaatccaag ctgcttcttt ttaatttcaa 127260 tcatgacgca atagcctcag cataaagttc atttgccata attacgattg cttctttatg 127320 ttctgcaccg atactggaat ttgcgacact ttcggcgaat aaacccatta tggtcatcga 127380 actaccagaa gtatccatag atgaaacagt aagagtttca ccatcatcgg ttatatcaga 127440 tgaagaatca acttcaattt tggcagattt gttgatagtt ctcaaatcat gaacaatttt 127500 agacagaaga aattcaactt ttgtcaagcc ttcatcaact tcattagcaa tcaaacgaac 127560 tgaacagcca gagcactctc gaatttcttc tattgtaaca ccaggataag tcagtcgttt 127620 gtgccatgtt ttggaattcg gaataaattc aaattcacgg gtttctgtgt caagaaccca 127680 gaaaccgcga gggtcatctt catcaccggc tgtaatcgta taaggagtgc cgatgtagtg 127740 aatattttca ccgcctgatt gagtatgaaa atgtccagag acaacttttt catacttttt 127800 caaaaaatct ccactgtatc ccgaactcgg aatatttttg tagaaataga atccgcttag 127860 ttcccaatgg ccaagacacc acggggattc tgactttttg acaaactcga aaatgtctga 127920 tgcattttct ttacacaacc acggaataag gtcgtaatca agaccttcga aattgaccgt 127980 cgtcggttta tcaatcacga catacgtttc atctttaccc agaatttcgg ttacgctatt 128040 tggatgtatt ttatccttct tattcatgtc gtgatttccc acgatcacat agcatataat 128100 accagcttct ttcaatttgg gcgtaattcg agtcctgacg aattccattg tacgttgtgt 128160 tacagccttt ctaacgtcaa aaaagtcgcc actctgaagc cattgagtta tcccatttgc 128220 tttagaatat tcaacagcct ggtcaattat gtgttcagcg atgttttcat gccaagggtc 128280 atcatctttt acgccattgt gcatatcacc gagatgcaaa agtttcatgt ttaaatccta 128340 atacaaaaat aggctccgtg gagcctataa tagatcaaat agaacaaact ggaacagttt 128400 gcgattttgc ttgattattt ttctgtcggt tggatggcat tagcatatgc attagccatg 128460 tcaacaattt gttgacgact agtttcaaac atagtgatca ttgcggaatg cggaagttgc 128520 ttttgcttgt aaagggtacg aagtttactg atagcatatg catactgttc tttattgttt 128580 gcgaataaag ctcgttcggc gtgtttcttc agccgcttaa tttctctccc gtgagtttta 128640 agatgctttg cggctttttt ctcagcttgt ttttcaagat gttcttgtaa atccatgaga 128700 ttctggtcat aaacttcact cagagcttct gcaccagtgc taaggtcaac atcgtaatca 128760 ggcgacatat gaaatctcca ttgtcattgt gtctacatca atatgccaat cgagttggcc 128820 agtttctact tcgaacggct gccatgaaat attggcagga tttaaaacta caggaatatt 128880 ataatccaat aattggagtt ttacgaaata cgctaataat tctatttctc cgcatgttga 128940 atcaatgatg ggtaaaagat taatcttcag ggtcgtcttc atagaatgaa tccaaattag 129000 gaacatcctc tttatctttc tttttagatt taagggatga ttcataggct actagtttgc 129060 catggatgtc ttggatgaaa ttttcatcaa ccaatcgtga catatcctca tcatgctcgt 129120 catacacgtt ggtcaaaaaa taccggtatt tgattgccat ttcgtgtttt tcgtacttga 129180 tgcgtccaat aaaggcacgg taacaagcct gtgtgatata cgcgtgaggg tttttgtaat 129240 tatcttcgtc gaaatttatc aaacccttta caacagcttc gactgcatca gatatcattc 129300 cgtctttcca attttgtgta taaccagcaa atttgtaata tccggtaaaa ccttttgcaa 129360 tcttcataat gtctatacca attgcatctg gcatcttgat gtgatgtcct gcatcacgca 129420 tatcttgttt ccatttgcaa atattctggt atagaacttc attgtcaaca tatttcatag 129480 ggcaattcct cctatgattg attatatcat actaataagc ttgctaaact tatttaactt 129540 tactgcctgc aggttttggc cctgccaaaa cttatccttt atggcttaat agatattata 129600 actaaaagga taaaaagata agttcaagcg agcttgaacc tggagccagg atttctataa 129660 tcaaccaggt ttaaacaagg tcattagact aataacctat catacaaact ttccagtatc 129720 accaaaatca caccggtaat acctgaagtc acatacaacg aaggcctcat gtagaggcct 129780 tctttttggc tttttctcgt gttttgatta tccagtcctg gacaatttcc tggtcttccg 129840 cagaattgat atcgagtatt cgcccaagtt ttctcagcag atacttgtat ttgaaccttt 129900 ctttctcggt catttggtat agcgcttgat acgattctcg atttcttttt acctgtttgt 129960 gattttcgat tgaattaccg tcacatatct cagcgtgcgg caaatatctc aacatatatt 130020 gagctaattt catatcagga acatacaggt tgatgggttt tagcgaatgt tcatttcgga 130080 tatcacatct tgcgcaaagt tgaaatgcgg gttcaagata ctttgaaact atgtacgcgt 130140 caaccattgc actttcatct aagcctaccg actttgcgag ttctttcaaa attggaactt 130200 gccagggtgc cggattatac gaaaacatca caaccacatt ggtataatcc gaatagttgt 130260 ttagaccgtg cggattataa ggaacttccg tcccctttgg cattcttggc cgataagaat 130320 ttcgagtgta aatgaaatcg ccatttatga ttgtgtcgag agtattttcg atgcgagtgt 130380 aattcgaaat cccatctact tccttgtcgg ctttgtaacg agaccaatca tcatcaaaca 130440 ttacatgaat ttttacgcga gcagttttag gataaactcg gaaagctaac cgctcaacta 130500 gcggagactc ttcaaattcc catccgttaa aatgcttcat gatcatgccg gtaaaagtct 130560 gctcaaaatt tgcagaacag acagttattg acttgaattt tgcccaatca tcatttgacg 130620 catcattcac gtaataacac tgcgtcacac ctccctctac tgacagcctg acagggacac 130680 cagtcagcag tgctttatac aaaggaaaaa gcgttgaata aatgtcatca tttcctctaa 130740 agccatctat tgccattttt tggactgatt ttcgatgctc atcacgcagc tctaatagtc 130800 cagtttcatc tattttgcac aattcgagta tgtggctttc gactgatgtt gtgaaagtaa 130860 agcgctcgaa gcttgttaat tctggaacct cgtcgatata aagattaaaa tcttttaaag 130920 catcaatatc tcgaaggccc attaaagccg catgcgttat aaaaatcaca tcaaattctt 130980 cggatgcttt gataactgct tcatgtactg acttttggcc ttggcggtta tcggtgtcaa 131040 ctaactcgcc ttctccaccc agaccaacat agtattcgaa agattgtttc gataattgtc 131100 tagatatgct ggctataatt gccttttcat tattttcgac aatatgattt agaatagctg 131160 cagtttttcc tgcagctggt atagcggaga gagtgtaaag tttcacagat ccaaaaattc 131220 cttaagccgc tcaatgtcaa actgattgta gagattataa cactccacac cgtgacgcat 131280 tgcaagctgc caagcagtat ttgttcctcc agaaacccca ttatccgttg gaaccgaata 131340 acacaccaag aattctgaag gtgttttcag attataacct agaacttgat acacatttcg 131400 agtatgaagt gcaagagcac cacccgttaa tttacctcct ttggagtaaa ttgggtggac 131460 cgttttcatg atttgctcgg cgtcccactc attggcgctt ggtaaaatga ggttgtgacg 131520 agcatgtttt ggtgcaaaac ggccattgaa tcgtttccat ggcagataaa catcaaattc 131580 agccatattg tcgatggcta aactatcagc aactgccaaa aatccagttt caaatgcgtc 131640 atctgcttta tcggcaccac cagaacgtcc ggtatatcct ctgatcgcag caaccgccgc 131700 gatatctttc atcaaacgac aaatatgttc gggagtctcg cgactcccta caccagtata 131760 aaagcccttg aaattcattt taattattcc atgtagataa attcgctaac agctttctcg 131820 gcctggcggc tataatttct cgttatataa ctccgacaac gtgtgcacca gccggcacac 131880 gaatggcatt cagaatgtaa tgaacgtgcc ggtgaacttc gttgtacaat tcggggtcat 131940 aaccgtcagc atggaaaatg atatcagcac cagaagtagt acgtaaaata tgcatttcgc 132000 aaccacccgg agaaacgcgg tcgatatttt tcaaatccat aatatagcga tcaatcggac 132060 cagcgtgacg gcttgaaaca ataattttga attccattat gatattccta tttcggaaga 132120 cagcgaaagc cttcagatac tttatttgga gctaagaaaa ttatcgcttg ctgccgtaca 132180 tttcttggcg gattttgcga gcttttcctt gatatttctt gtacgcgtct tcggcgactt 132240 gcttgtaacc tgcgtgtgta ggagtgtggc caagcggctg ggtaccgaat tcatccgcga 132300 tatattgcac aataacactg cgaatcgctc ggcgtccaat gccagtaaca cccgcttcca 132360 tcatagcatc ccatacagtg ttttcaactt tgtcgatcat ttgttcggtg atttcacgac 132420 caagaatatt atcagcggtg aattcggcgg cagcagtgtg tacagcgaag ttacgaacgg 132480 caatgaacgc gttagacata tttgaattcc tctctaaaat ttgaatgctt gtttcggcta 132540 tattatctta tcacgattga cggtcattgt aaactgtttc agtctctctt aggagcagtt 132600 cggcggcaat agtctacaaa catttcaatt cgcgagattt cgggaatgcc agaataattc 132660 gacaactcac ccaatagcaa catttgattt gggcagctga tcgacatgtt atagcctttt 132720 tcaagcatga tattgataag cacgtcctcg gtaaatggac cattccattc tttgacaatt 132780 tttacttcag tttcgcggtt gtttaaagcg agtttagtgt aagccaattt tgtataaccg 132840 atatgtgaca actggggatg tgcagaacgc aggagtttga cgaatttgat tgcgtcacca 132900 acggctctga aatctgctac aggcaaaatg ttatgatgcg cgatatactt ttcaccatgg 132960 ctggcttccg acgtccgctt ccaccgccgt tctaccccaa tttgaatacc gccagagatt 133020 tgttcaaggg cagccgcagc agccgacatg ccagaaacag ttgaaagata ctgtgcgttc 133080 aaattcaaaa gatcactcgt tttaatctta ttgagtctaa gactatcagc agtttcagtg 133140 gctctagaca aagtttcata atccatttta gcactcccat catgctcttc atgttcaatc 133200 tgacgatctt tacctatcat ttcgcgataa gtctttttca tttcggaatt ggacagttcg 133260 agaaacgaat cgatcgtttc tttggcttct tcggttcggc tgatagtata tcccatagaa 133320 ccagcagtgt atgcgtcaat agattcgcct ttcgcattgg tatatgtcat tgtcgcttga 133380 ttataccaat agttagttcg aattccattt ggatcgacca gtgttactag tgttgagcaa 133440 atcattaata tactccattt tcaaggggcc tccgaggagg ccctttttaa ttatttcaga 133500 ccattgatat aattttcgat ttcgttaatt gttacagcgg tttgtttatc gccgttgaag 133560 gtttcgatgc gcatcataac atcgttgaca tcgaccttgg tgagaccagc caattcgata 133620 acatcttcag agcaagaaat accaagcgct tctgcattgc gagtttcacg aataaactcg 133680 agtttagcag ccaagtctaa gcgagaattg tcgagttcaa caaccgccag cttaatctcg 133740 tctcgcattt tttccaactc atcagctttg gcattcagcg catctgccgt acgacggtac 133800 agaatagcaa gtttaacatg agtttcgacg ggaacatttt gattcatgag catacgaatt 133860 tcattatctt ttcgccgcgc ctcaacttgc ttatcttttg catattgacg caaccgtttt 133920 tcttctgaaa cggatttcac gtgtgccgtt tccagtcggg tgatttggct aatcacttgt 133980 tctgctgctt tcgtatattg gtcttcgatt gaagtatttt tcttgacaaa cgagttgatt 134040 tttgtacgaa taaattcggc aatatttttc atagacatag tttttctcac acagttgaca 134100 taggattagc aatcaaacgc attgctttga tttgtttgtt ctttttgtca tacacaagca 134160 tatttgacca accaattgtt cgctggttgt cttttgcgaa cttgcgaact tcggccagtt 134220 gttgaggagt tgcagtaatt ccaaacagtt tctcatgctg acacaacggt gaccagatgt 134280 tcaagcctac cattttagca gtttgccaat tgattggttg gcggcctttg ccttctgcgt 134340 caacatagcc tgtccatgct ttgccattat tgggcttata cccaagaatc gcaaacattt 134400 tgttcatatt ttcaatgata ttcggtatat cgatcataat gtaaatctca ttcacttgac 134460 ttgtgactta tcttatcatc gcaaaaacac cttgtacact acttttacga aaaaggcctc 134520 cgaagaggcc tatgaatcca gataatccag gagagctttg gcaccaccga tgtatatccc 134580 attaacaaaa accttgggaa gctccaggga acctttgggt tgacctatgc gacgtctgag 134640 ctcatcaata acgtctcgtt tgtactcaaa accgagatca gttttagcat cctgtaaaac 134700 ggtttttatg gaatattcta tgccatcttc ttcaagacgt ttgacaataa agtcgcacgc 134760 tggacatttg cgcgattctg aaacaattcc gtatatttca atcatgccat ttctccgaat 134820 agatacagct ccatcggtct aacgtcgctt ccgttggttt gattcttgtt atttcgacat 134880 caggtctgta gccaactttt gctatccagt tataattagc tattcctact ccagttacga 134940 catcgccgcc gtctagcagt actcgatact ccactcgata agcatcgcct gggccattgt 135000 atttctgtat tttttccaaa atactgccta catgagtccc atcatattct ttcccaaaga 135060 aaagtttagg agggcggttt attaactctt tagcttcttc aaacatcata tcggagactc 135120 ccaaataaat tttcgtttgc atttacggca tcgcaaatcg actaccttgt gtgtccacga 135180 aactagttgg atttgatcag tatcgcagca tgggcaacga aatttttgtt ttgcgacttc 135240 ttttctgcgg tcaagcatta cgtcatattc attcgacgcc aaataattcg aaatagtttt 135300 agcaatatga tcttctgaaa taagttccga tttgactcgg ccagcttctt tttcttctgc 135360 gtatgcattt cgcaattccc gcattcgagt gtgttttgcc gtacgggcag accattcagc 135420 ttcgcgaatc tgcttttgtg cttcaatatg catttcaata tccactacat tctccaatta 135480 caaaaatgcc cagggtcatt ataacacctg ggcataaact attaacagct tctattcgtc 135540 tgttttagga ttttcggatt catcctcttt ttccggttct ggggccggga tgtcagttct 135600 gacgaacttt tgttggacta tgtatccttc cacagtatac ctcctcctat gtgaaaatcc 135660 atatttattt actgtgaatt ttcaggagat gttggtttcg tttgaacaat tcatcgtatg 135720 aattgccagc cctgacttga tcggcgtaaa ttttcacaac gtcacaataa ttttcccatg 135780 caaattcacg gaaccaacca gatgtaatag aagtgcatac tttctcaagg gccatttgaa 135840 aagctttata gggttgaact tttcctggga aaggaataag acagcgttcc agagccaaaa 135900 cacaagattc ttcataaaca cccatcaact gaatatgacg agagcaatta aagaattttt 135960 cttttgacgt cattacttca gcgccatcaa ccatgtatga tcgatatgct ggaataccgt 136020 caaccgccac agcttcgtga attgtatcat gatcataggt gtaaatgtca tctttgaaaa 136080 atgcgccttt accgacatta agcttcggat ggccataatt cagagattct tgttcacgct 136140 ttttgaaaat ttccacatgc tcgggcccca tgactacgcc aaattcgcgc aattcatgaa 136200 tgtgcatcat ggttttgatg aaattacgag tgttcttttt gaaccgatga gccattttca 136260 tggctagaag aatttcggga gtggcatata cgtctttacc gggaacagta tccatgagtt 136320 tgtaaatcat ctcatcggac gagccagact gaacaatata tgcttcgtga taacagcatc 136380 gagatttacc atcaccaacg acgaaagctc gaacattcgg gctttttact gcaatagtcc 136440 gaccttgcat tctggcttga tattcgttcc attcttcttc gtacgcaatg aagtcatggt 136500 ccatatttac tgtaggagca acaaatggaa ttagcctagc ttgaaaagca cgagagccaa 136560 caataatcat aacaaaatcc tcaaattagg gctccgaaga gccccttaat tagcaattac 136620 tttccatcca aacggagcca tccgcgttga cgccgaatgc ttcagaacct tcgccgtagc 136680 aactgcttga cagccagtca ctgaaatcaa cttcgttacc attgatttcc atgccgtaat 136740 cgtgttctgt tgccagcgct tcaacttcaa caagaagttt ttgaagttga actgcctttt 136800 ctaccaattc attagaacga gccatttctt ttctccttaa cacatatcag aggaactgag 136860 ccagtagcca ttctcggttc cttggccata ttcttcggca ttgctttctg tccaaaagcc 136920 gtgaccttta ggataatagg tgcggccata cccataatca ccagtcgaga aggaaatgca 136980 gaatcgatca gcaacggctt gagcgattga ttcaaattcc tcagacatag aattcagttt 137040 gcggattgcc tgttgagctt cggctttatc catcggggtt tccagaatgg acttaatatc 137100 ctggaatttc ttttcaaagg tttcaatact ttgcttaata tcagacataa taacctcatt 137160 tggactgttt agtttgtgca aatgtatatt aacacacatc tgcacaaatg taaacaagtt 137220 tttaaaaatt atttcacgtg cttgacacgt gatgaaacct cagcttgttt gcctttattg 137280 aatcctctcg ccaacggagc accaagatac ccacaaactc ttcgtataac tgacatcttt 137340 gccgagtcgt ggttaccaca gctcggacaa ctaaatcctt tcgaggtgca tttgaattca 137400 ccgtcaaaac cgcattcata gcatttatcg acaggtgtgt ttgttccaaa ataggaaaga 137460 ttttccatcg cgtaatccca aatttgctca agggcttcga gattgtttcg catattgggt 137520 agttcgacat agctgatatg cccgcctgat gcaatccaat ggaattcttt ttcggcatct 137580 attttgtcat acgggttcaa ctcggcatca acaggaatat ggaagctatt cgtataccaa 137640 tccttgtccg taattccttc gataacgcca tatttcttgc gatccaactg gcagaatctg 137700 tcgcacagcg attcagacgg agtagaataa aggctaaagt tccatccggt gttgagtttt 137760 gcttttgcgc atgaaaaatc gagatatgtt gcaatcgaaa gcgcaaaatt gcgtgcttct 137820 agatcattgg ctgtcgattt gccagtcata atcagagcag cttcataaag gccaatataa 137880 ccaattgaaa tcgaagctcg ttctttcaaa tgcggcaaaa actcttcttc cggattaaga 137940 tatagaccaa aggccccttc agtgtagaga attggggcgg cttttgcctt agcaccttct 138000 aggtgtttaa ttcgttcaag agatgcttca actgacaatt caaaacgttc ttgcagcagt 138060 ttaaagaatg attcctgtga tccgtttgct tcgatagcaa tccggggaat attgacagag 138120 acaacaccta aattgtttct gccatctagt tcgccagact ttataccagc caggaaagac 138180 cggcaaccca ttggactaac aggagtctta ctaccagtga tggatcggtt gtttttcgcg 138240 ctgataatgt cagggtacat tcgcttggct gaacattcca gagcaaggtg tttaatttca 138300 tagtttggat ctccaggatt taagtttata ccagcttcca tgaacataac gagttttgga 138360 aataccggtg tgatgccatt ctttccgaga cccttgattc gtactttcaa aatagctttt 138420 tgaatttctt tttcgaacca attggttccc atcccaaatg taattgtcac gaacggtgtt 138480 tggccattcg tggtaaacat cgtattgact tcgtattcga aagcttgcat accgtcgtag 138540 atttctttag cagtcatctc atatgcgtat ttttcaattt tctcgttgtc actgatgaaa 138600 ctacagccga cagaaaaatg cttattccat gacattatgg cgtatggcgc aaggacttgg 138660 tcaacgttgg caagagtagt cccgccatac tgatgagaag aaacttgtgc ggtaatttga 138720 gccatgatag ctgaagctac accaaaggat ttaggctctt caatttgggc atcacccatt 138780 ttgaagccgt ttttgaacat ttctttgaga ttaaccaagc aacaatttgt cattggaaga 138840 gtaaaagcgt aatctaaatc atgaatgtga atatctccac tatcatgtgc ttcgattaaa 138900 tgagatggca gaatgctttt agcgtaatcc tttgaggaga tagatgccat catatctcgc 138960 atagtcggga taacgtcagc gtttttattc gcattttcgt gatgcaggcc agattggcct 139020 tctactaatt gctttacaag tgatcgggta gtcattgaat ggccttctta aattgctttc 139080 tgaatttttt gactaaaaca gctttttgat ctttttcatc aaattcaaat cctcgttcac 139140 gtagttcagc cttcatttca ctcaagtttt tccgtgagaa atttttggtc atgtcggaaa 139200 cgtaattcgg gtgtattgga ttttttgaat gatctgaatc tacatattct aatagtgatc 139260 tcatccattg gatgtaatca acatcctttg cctttaatcc tgaccgtata aacttgtgct 139320 tcattatgcc ttcaagtaga ttgcatctac tgcaaagtag acctcgaatc tttccggcat 139380 tcgggccttg caatacgtga tcgtgatcca aatgctgttt attgtatgga ccgtcaaact 139440 cgtttccaca caatttacaa cacttatttt gttcttcaaa caatttctgt tttaattcat 139500 cagcagactt ggaatttaag agcataaaga ttcctccata tgctcttatt taattacacg 139560 gttacactgt acttcacgtt atcgttatca gtatatacga tttcatagct ggcaaggttt 139620 tttggatatt caccatcatg gcgtggccac catagcgttt caacaccgta tttttcccag 139680 atttctatgc tttcttcctc ttcgcagaaa tagcgatagt agtcgggaat gtcggtgaaa 139740 tcgtccagac cacccttacc gtttgggtat cgatttttgc atttttccag gaaaatggca 139800 agacgctcaa tttcaataga agcttcgttt aaattaacag ctggtagttc ccagtgaatc 139860 gttttatcat caaacttgtc actgaagttg atggtaactt taaacatatt acgttcatct 139920 tttgctttga attttctaaa cttgagggtc attttgccac cattataacc tgtttggtgt 139980 tgtagtctat tgttgcgtta tatattttac cgtcttgggc aaaatatttc gaatttccaa 140040 tttcaacttc ttctatatca ggaaatgccc aatatatcgt gtttttgatt tgttcatgat 140100 ctgtcgacaa aagattaact ctgatattgc caccgatcac cctggtgaat tctttggcat 140160 gattatgtat gcgcatacat actcgcgtca tgagggatta tgggcaaaat ggattgatat 140220 tcctgaaatg acaaataaac atattcaact tgcgggacag aaaaaactga acgcaattgg 140280 ttgattgttt cattgtttag tggatattcg tattggtcat tattttctag agcctttttg 140340 aattcatttc ttgtcagttt gatttgcatt actttcccac tccgcttttg acataacgat 140400 atgaccccat tcaatagaaa caataaagag tcgtaaacga tttaacttat acccgtcgta 140460 catttggccc caatatgatg gaagatgtcc gaattctcca tcaatcgaaa aatattttac 140520 cagatatgaa tttttccatt cgtagattat tttcttttta tacagccatt cttgttcata 140580 ccacttgata attttgttga tcatgatttc tccagtgtca aatgccctct tcggagggca 140640 tttgatgatt acttaattgc agtgcgctgg cggatttgag ccagattgct cttgaatttt 140700 tgaccttttt cggcgtcata ataacggacg aatgcatctt tcgacataag ttcaacaaaa 140760 ccgtctttga tgcttacacc gtacagcatt tgaccacctt caatagttcc ttcggtgtaa 140820 taacggccat catccatgat tcgcagtttg agctggcctt tcttggaagc tttccattca 140880 gcacctttcg ggcatttgaa tacgtctttc catacaccat tgattttgat ggcagacatt 140940 ttcatagccc acttgcaggt gtctcggttg accatttgca gaagaccgcc acccatgccg 141000 aacgcaatat tctctgcagc ccaaccgcga gctttcataa cagtcagaac acggtcgata 141060 acttcgggcc gtcgatgcca tcaccttgaa taatgcggca atgcttattc agaaccttgt 141120 agcccttgct gttggtttca taaccgaaga tttcacccag agtttccagg gcaaaactga 141180 tattgtcgat catatcacca ctgtcaggcc gagcgatcag agtaccaccc ttggcgataa 141240 cttcgtcctt atagctctca atttcgcgga ttgccttctt gaaatcggta gagtcgtaca 141300 caatggaata tgcaccagca ccaaagagtt caaccgagtt gaggtaggcg tctttttcac 141360 ggtcggcacc ccaagaggtt acggtggagt gctcacgggc tggtacagag atgcctgcca 141420 tttcggcgcc aaacagttgt tttgcgaaat acagcgactc gaaagtgtca gtacccatgg 141480 agttgtacag atgagcacaa ccgccgattg cagcagattc accagaacta acgccgcgag 141540 aaccaaaatc atgtagtcgg gtcatcagca caaagttgaa ctcaggactg cctacttcca 141600 ggtcagaagt ttcaatcagg tggcggcgaa tagatttgat acattcgcgg ctcagcgtgg 141660 caacagtaga agtgtaccag acagctctca aaatgattgg ctcaaaccag cccgccagcc 141720 aaacgaatgg tgctttgaca cgaacagtca gcacaacatt cttgactggg acaacagtac 141780 cttccggaac agcatcgatt tggatgggca gacagccatg ctgttcttga tattggcgga 141840 ctgcttccca accttcacgg ttgaatacgt cttggccaaa gtgagccttg ctcatggcat 141900 ccatttcgtc aatatcatct ttggtgatga tttctgcaaa cttggtcagc agatattcca 141960 cgccaccgat aacgatttca tcgaatttgc caccacgagc ttcgacgtag aaaactgctt 142020 cttcggtacc ttcaggcatc tggttccaat gggtgatttt gtaagaatca gtcattgcga 142080 tcagagggat acctttcacg ccggtgtgtg gacggatcat attcataatt aagccccaat 142140 tgagtttttg atgattttca tgttgtcttc gatttcttta cgtagtgctt gcaacttggc 142200 gatttcactg tcaatttcgt tcaaccgttt agagccaaag tggagtgcac ctcgaacagt 142260 gttgatagct tttccgatcg cttcagaaaa gaagatgctt tcgcaaattt ctttctcggt 142320 ttcgagatta acaggttctg ccgaccgtgt ctcttcgaca acgtttgcat cttcagcaac 142380 agacttgacg ggtttaattt cgcgcaagat gatgctgaat ctaactactt gatttctgcc 142440 attttcagaa atatcaattt ttacagcagc cccataatgc ctaagcagtt ccagtctcgc 142500 cgcaaaacaa tctgcttcaa acactgtgtt gagccaaata attcctttaa tcgtgacgtc 142560 gttttcggca tcaacattaa agtagtttgg cttgattttg gagatgccat tgtatttgcc 142620 caacgtcgat gtaggcatca aattcggcaa aatatcattt accagcttca tgaagtggtg 142680 ataatttgcc aaccgttcag ctacaggctt ataggtttta aagcgattat tggaagtatc 142740 ccgacgattt tccaaaaagt tcttaactgt cgcataataa ttcattcgca aattctcgca 142800 ataatggttg aaccaataac tgccatcgca catccgagaa cggtgtaagc atttccgata 142860 tacatcgaat aaaacaacgc aaatgacgct atgtacccaa tgttgattgc agcggttttg 142920 atggacattt aaattactcc gttcgtttac tggtgggaac attataacca atgttcccac 142980 cactgtacac taacttttca atcaaatacc gtaatttttc gaaagataat cgcggacatc 143040 ctgtcgtgta ttttgtagtt tatcttgcaa ttgggcaagt tcacgagaaa gaacgtcgat 143100 tcgtgattcg agtgccggga tttcttctag cagtttatcg atgctgatgt tacctttcat 143160 ggtatcaatc tcttcggtag tcgcgtaatg aatgttttca ggcttaggat gaacccgctt 143220 tgtgcgaagt tcggtattcc gacggttccg atagcgattc agaactggca aaactaacgt 143280 cattcctctt gcatgaattt caatttcaag aagtcgtgcg agcatcaata cgcttttgtc 143340 agtagaaaac gccaattcac cgactcgcga gacacctctc tcatacgcat atacggttat 143400 accggtgttg gctttacatc gcggaatatg gttttctctc ataattcggt caattttgta 143460 ccaaaaccat gccggaatcc tgactgtttt ttgatactta ctattccata ccgccgttgt 143520 ttcgacgttg aacattttgc aaaccagatt aagccaatcg cggtcatgat gttcagattg 143580 caaggtgttc aaaaaattgc gaacatgagc aatgtcgttg tgacgccggc gttggtgttt 143640 acgttgagaa cgaagggtag attttccact catgatttgt cttccttatc ggtaataact 143700 acaatagcct tggcgctttc ggaaacatag tcgtctacca taaacaccgt gatttcatca 143760 gaaacgtgac atttccggag aatttcataa cagaacgaac aatcattttc agaaatacct 143820 ggtgcatcat gcagaaatat aaagtcttcc ttcacccgcc aataggaatc gaaaatttca 143880 agttcgccaa ctttattacc gatgagtgat tcgacttgga gtttgctttc caagtacacc 143940 tttacgatat tcagttccat tcaatacccc aaaacgaaca ttttgttgat acattgaaga 144000 aatcaccaaa atgtgcagat acagaattga cgatttctgc ggagttctgt gcaaccattt 144060 ttgccatttc agcggcttta atcatttcat cagtcccttt ttcataacga ggaaagttgc 144120 gccagcaata ataccagcaa tgaagatttt acgagccata tcgatatcgc caataaagca 144180 cattgcagcc cctgctccaa cgattcctac ggtaataccg gcagcaatgg tttcgaatcg 144240 ggtaatttta acctctttgg tttctgtcgc tgccttaacg acacggccga cgaaatccat 144300 ggattgcagg ttagttgatt tagtgatttt catgacatac tccttgttga tttgatggga 144360 ctatagtaaa tcatagcccc atcaatgtaa actgtttagt ctactttttc acaaaacttt 144420 tcaaactcaa aggaggcaaa aggaaaccaa ccttctttcg aagaaacaag ttctttaaga 144480 gttttaccgt cgaaaacact cttaacttgg ctgtgtttgt tgattctagc aataaaaact 144540 gtgtttgcgc tgaaacctac tgcccaaatg tggcgtctga accgagtagt atactcagtc 144600 agcatttcct tacttttgaa tttaaagcga accaatttca ttatttgctc tccagatatt 144660 ctttcattgc ttcagcgtaa acctgttcga caaacgcttc ccatggcctc atgtccactt 144720 tatcaggcat tccgttcttt gatgcctctt ttgctgccat gtcaacagct tcaacgattt 144780 cttcgaggcg ttcttgaaca atagcgaaag acagtttgcc agctttaacc agtttgattt 144840 cttcagcatc agccaatgga tacttcaaat cgccagtttt gtaaatctca agcaactgca 144900 gaccacctcg caatgcgtga cttagagctt tccagtcgat accttcattt gcttcagctt 144960 tgcgagctcg atcgccgtat tcggcccata gcttgtcgac tgccccacag aattcagcaa 145020 tcttaacacc agccatgtac ttacggccca tcatggtgta atacgacatg gtgtcgggat 145080 tttcttcaat gtgagtccag aagcagaact cgttttgtgg aagaggaact ttgaggtctc 145140 gcagccttgg gttttcatga atctgaagag catccatgaa ctctttgact tctcgcaatg 145200 ccgctaaacg agaaccttta acaccatatt ttgccgcttg cttcataaca taacccatat 145260 aggaagtcat gttggtcgtg tagaaagcag atcggttttg gtggatatat tgccaaacag 145320 acgaattggt gatgattttg tcttttggag aatgcaacat atccagcgca taggtttcgc 145380 ccttggccgc atccagaatg aattgctgga gcgaaaacat ttcgatatcg atatcatcct 145440 tgctgttctt ggacttatcg ttgccagttg tgacggaata gctccttttg gctcggccaa 145500 gcagaatatc tttgggatcg gggatgaaaa taccctttat atccaagtca gattcaggag 145560 tattgagacc gtaaagatga gagccatgaa ggccctcaaa aactactttt tgcataattt 145620 ccaccttaag ataatttcat gtcatatgct ttaagttgat cacgatcgtt gcggttaacg 145680 aaaactgact tatgataatc agcatcccaa gcaattagag aaccgtcttc tgcgatgaat 145740 ttaaccacgt atcgtttatc atgattacga tggatgaatt cgtcgccgac ttgaatcggg 145800 gtgtaaacag tttcttcgtt ttctttcatc acgccgaaat gaccactgac gaatttgatt 145860 tcggaagttt cagacgtttc accccagctg gtaatacctt cgggagaaat ttctttaaac 145920 tggaaaaaca tttcgctgca gtcagtggca agttcgataa taacatgaat tcgactcatc 145980 tttttgcgta aaataatcat tggattttca gtgatgcaac aaactgttgc aacttcccaa 146040 cgagcatttt ggtatcgcac gtcatcaccg ggtgtaaggc gctcaaattt ttgctttttg 146100 attttcttgc gaatgcagat tgctttcatt tttattctcc tttagtgatg ttacaacatt 146160 ttccgtaatt gtatcctaga taccggtgaa gcgtgaaatg atttcagcat gatcgtcaaa 146220 catacgtgcc cgatttctct tgtattcatg cattggcatc caaaatgctg cttttgcatc 146280 atcatcagca cgaacttcag gcaaactacc gtcgtcattg ggttgaagta cgatataata 146340 agcaaccgtc ggtttgcaga actctgccgt tctctttggg tgatcaaata cttcgtgtgc 146400 ttttatagac ccaatgattt tttgacgatc gacatcaatc cgaacttctt catacaattc 146460 gcgaattgca caatcgcgga aggtctcatt ggaattcttg tgaccacctg gaagagcaag 146520 agcacctttg cctggtgcat gtttgcggct aataaccaga atatggttgt tgcacgttac 146580 tacggcatca gcagtattgc agttgagagc atcagcgtat ggataatctt taaactttgc 146640 aagttcattg tcccacatcg cacgttcttc catcaaccgg ctgcgtattt cggaaccttc 146700 ggtattccaa aatttcaaaa gaaatgaccg cactgacgga ttgataggga aatcgtcgtg 146760 gatagaaccg gttcgaagaa attcatcgcg cattggggta tttgagatgt cttttccgtg 146820 attctgaacg cccatgcatt gaatatggtc ccatccaaag gttttgatcc aataagaatc 146880 ttcatcctta tcgtatgcaa tcatcgcaac acgctcgccc ggttgctctt gcgcggcctc 146940 acgaacttct gtttgccagc gatcttcgtt ataacggtag tcaggaacat tacctaaaac 147000 aattctggcc tgttcgctag gagtgagatt gttactcatc cattctttga acattctgat 147060 tcgaaccagt gttggaagcg ggttgactgt gtttggataa caatgggatg acccgaagac 147120 aacagcaaca gtttcagcag tttgaagcgc tttgtaaatc agcatttcat gtccacggtg 147180 gaaaaagctg gaaaagcggc caataacaac agcacgatca taattataaa ccatgtcaat 147240 aacctcgacg aatcattgta ttaatttcta tctgattttg gcgccattca atgttggcgc 147300 gtcgaactaa tcctgctgtg ataaaaaagt cgacaaacca gccaagacca aacagaccgc 147360 aagtaaaaaa ccaaataact ccggtgacat aatttctggt gtagaaacgg tgaataccaa 147420 aaacacccag aaaaaaccaa agaacatacg ctaaagctgt agatttcatt tataccaacc 147480 gttcaagacg ttcaagacga ttttcaagtt tagacatgcg ttcccgcagg gccgcgtttt 147540 ctgcaagcaa ttgctcaaca tcgttatttt ccaatatctt ctgggatatc tcgtgagcaa 147600 catccccagc gcttacttct tccaaatatt cttttacttc gttagctaag aaaacaggaa 147660 aatactcggg aaacaaagta ataccgttga tttcgaaaaa aatctcatcg atagtatttc 147720 gtggcatagc tacgtaaaac acatgatcgc atacgctatt agcaatagca gcattgatgt 147780 cgcttatggc agcaaattca tgtcgagctt catcagattt gaaacgatat cttttcataa 147840 ttcctccaaa tggccccttt taaggggcca cgatcatatc agtgatacac tttgtgcgat 147900 ttttgcgcag gtttaacaag ttcttgagta gcaattactt cataaccata tgcttcgagt 147960 tcggcacata ctgtaatcca agggccgcga ctcattgcga agttgacatc cagaataatg 148020 gtgccaaaac ggtcgaaata gccaagatct ttgaacattt cgggagttgc aggttccaaa 148080 caagtaacga tgtcatagcg gtttttgata gcaggattct gaatactgaa catgttaact 148140 cgatgctcca gtacagctgg atgctcttca gaacaaacga taagaacagg gtgattcatt 148200 gctgccatat aggcagattt gattgcttcg gcggttttac cttcgcctgc aggcttaagg 148260 ataatttgca tattatctcc aattagttat cgcttcgcga tcgagcttcg ctcgagtttt 148320 tatttccagt ctttttattc taaaccattg tactggtaat atacactaaa atgactaaag 148380 cgttacacaa actgccaacg tgtgccatgt ttgcttttgt gaggttctac ttcgctcacc 148440 gaaacgatca tttcagcgaa acccataacc tcttcgttgt tttcgttgac aaattgagct 148500 ctatgccgct cagaatgaac tgcgatagta tagcccgttt ctttatgttc gtaaacagtg 148560 aattcgcgct caaatgaaag cccataggac cactcaggtt tgcgcacaat tttccaaata 148620 ggcgaaatct tgaattctga tgcttccaca cctatttgtt tcgacagctt gtcgatttcc 148680 tgaagtatag acatttttaa atcacaatat agttgagttc gagatcttca taaccatcat 148740 cgtaataaca gtcgtttgta cgccattcat cagcagtgtc atcatccatg aggatttcaa 148800 ccaccccgtt gttcaagcgc caggtttcag accagagttt gccgtcatat acccagacaa 148860 ctacaaactg accatttttg ggcatttcat taacacgttt catcggttgt ctccgttggt 148920 tgattatgat aacattctaa actcgtttaa cgtaagagta caaccatttt gaattttatt 148980 tcaaacggat acaaaaatgc cctggttcac accagggcat ttgaattagt gcaatgatag 149040 tttatacatt gtcatacgac aaagctcttg gatatcatct gaggtgtttt tgagaaccgt 149100 attaggtgca ctggcagata ccttttccgc catctgggca agttggttga caaatgactc 149160 aaaggttcca ttataaatgg acagtcgcgg ccgatatgta aatcctgaac ccatatacga 149220 ttcagcgaaa atatcaatca gccctggcat attgtcatag aaatattcgt atgctatatg 149280 cttttcatac gactttgtca taaagtgcgc ggaatgcgca tatgtgcttg acattaaaca 149340 cgcaccaata aactcatcaa aaatgcttgt tttctcggtt acaacatcac cgaatcttac 149400 ttccatgacc ttctctcttt gctatgaatg tctttgcttc aagatatcca gtttgataac 149460 aactcgaaga gcatttggcg gatttccatt tatcgttcaa atgctcaaga aattcaaccg 149520 aattatctag agatggcact atttcgttgc tatacactat taaagcgccg cgcatgtact 149580 catcataaga cccactttca gggtccgcct ttacaaagtg cattgaagct aataccaatg 149640 cgattattga aaatgttttt aacatacgac aaatgggcca ttggcccctc cttgatggta 149700 ttaaacaaag gcaaaaagcc tatttgatgc ctttgtcttt accgcatact ggtttaacca 149760 atatgacaag gcatctggcc aatccgtggc tttatactcc tatcatattt aacgcattat 149820 ggagggttta aatcatctgc agtttgtcaa ttttctacta catgtggaat aaatcgactg 149880 ttattgccgg taattcggct atcatcttct ctgataccca aacccacagc gtcgctacct 149940 accatccata cgccaagcat tgggtagcaa ccatcgaaat ctttccattc gatatattcc 150000 tggacgatac gcggttcttc tgcgtaattg ccatcggtga attcactttc tccaccatat 150060 tcaaaaatat gaacattgca accttcgcga gaaagaagag gctttgacac ccatttcgga 150120 ttttcataag tgaacagatt caatcgatca aaatcatctt ccatatacgc tggaaccaac 150180 cattcacagt taggataacg ctcataaaga agaaccaaaa gtgctttgtt ggaaagcatc 150240 attttccaag ttggttcaat aaatcgagtg ttgctccaac caatggcttt gccaaaatcg 150300 tcttcataca gccattccca tggatacagt ttgaagcaag tgtcgatatg ttggccttca 150360 atgtcataaa aattaccgtc atcgccgagc tgaatttcag cgatatcaaa cattttgaca 150420 ttcagtcctg cttcagaagc ggtttcagcc atgtatgcaa ttgtagcaaa atcatcaaca 150480 tgcgtagtag ctacaaagct gattttatca ccaattgcgt tataagtgct catatcacgc 150540 cagtgattaa ccaacgcttc atgaatttcg ttaaattgaa aagcttcttg atggaatttt 150600 tcacgttgat cattgaacca attccattga gaaattgcag attcaatgag aatggtgggg 150660 gtatcagcat tatattcgag aagcttgggt ccgttttcag tcatgatgaa atcaaaccgc 150720 ccataaaggc cccattcatc atcttcccaa ctgcgcatga tttgatcgcg agaatcatat 150780 gggatattga acatgttgaa aatttcgttt tgctttttag tgtcgcatgt gaacagccat 150840 tccattgtct caagacacat ttcatggatt tcgtttgcag ctttctcgag ttgctcttgc 150900 tctgcacgag tgaaagagta atatttaggc tgaaccatcg cttcggccca ataaggacct 150960 tcttcagtag tggtccacaa aacaccttcg gaagtcaact gcggcaacca atctttacga 151020 gcttcaatag atacgcgttt cattctactt tctccaaaac agtgtcaatc caaattcggt 151080 aagcttcgtg gtaagttttg ccgggaattt cttccaatgc gtctgggcac aaaatgtaac 151140 caatttcagt ttcatgccca tcccagtcaa ctgctggacc gcggatattt ccgtattcat 151200 cttctttcaa ataaatttcg tcaccttggc taatgcaacg atgattcata gagatttcgc 151260 caataatccg ataaattccg tcaatcattt aaacagcctc caagcacatt tcgacctttt 151320 cccagtattc tgctgcagtg tacgatcctt caaacatcag tataccgtta tatggatttc 151380 cttcgatatc aaccgaaata tccattgaac gcacgccatg ccaagataat tcagtgattt 151440 caataatgtc accaacccca acaatatggc aagaattcac aggggtggta attcgatatt 151500 tttgaccaac ataaatcatg atgtactcct tgctgatttg atgggactat cgtaaatcat 151560 agtcccatca ttgtaaaccg ctttttgaaa ttaaccaccg gaagagccga agccgccgga 151620 ttttccgaaa ccgccagatg acattctcac caccggttta gaagatgcta ctggtttggc 151680 aaaacttccc ttgccgaagg aagttttgaa agtgtttgcg ccgatagaac cttttccagg 151740 aggaacgtat gaaccattcg cggtgacgaa gccatttcga cgatcttcag atcggcttgg 151800 tgcatatact ggcatcgggc gagcattgct tgacatcagt tggccaacaa tcataccaac 151860 catagctgga acgaacacat cgctgaaact gccgtcggaa ttctgaattt gtgtttgggt 151920 gcatacagca cccgtgccag attcacatga tgtttggtca ttgaatttcg gtgcagctga 151980 ggtgtgttca tcctttgctt gcttaaatgc tagttggcat tgttccgtcg aaccaccacc 152040 cagttcttgg cattgctctg ccgaagtcgc ggtgacggta ggcgtaggtt ctccaccgag 152100 accattataa gaaaatgtat cagactgttg ctcgccacaa ccagaaagtg ctgctgctac 152160 gaatgccgcc atgatgtcca ttttgagttg cttttgcatt tattctccga ttgttagtgt 152220 ttgtttattg atcacttgat tttttcggca aacaagaatt tcttcgccat ttggcgtaat 152280 tgcggttgtt aacccatgag ggcatgctga atcgatcgga ttataaattt cgttatccga 152340 aaaagccggt attgttatgg ctaacagaat aataacaatc gccactaata ccatcaattc 152400 gattaaagta aaaccacggc taaacataat atattccaat ttaacaagtt atcttatcaa 152460 aattggctcc cgaaggagcc cgagttaaat tacttggaac gcatgtccat cagcatttgt 152520 ccatcataac cagcgccgac cacagtctgc ggtacaccac cttggtattt gttggcacga 152580 atcatttcga cttccagctg gcgccatttg atcatttcag gagtaatggt tttctgtagc 152640 agggagttag cttcagcttc tttaccagca gcatacagtt tagcgtcggc atcgcgctca 152700 ttcgcaatag cgttttcttc tcgagcagct cgagcagctt cagcggtctt aacttgctgt 152760 tgagctactt tttcggcttt atccagatcc gcttgggctt ggtttacggc ttcttcacga 152820 attttggttt gctcaacctg gtcttgaatc agcttcggca gagtaatctc ttgcaggaac 152880 acttcggtta cttcgtaacc aaacggcttg gagtagtcat tgacttcagt tttgatcatg 152940 tcttgcagca tggactgagt ggtagcatcg ccaaacagat cttgcgcttt cttgatgttt 153000 ttgccggatt cacgaacagt actctcgaat ttcttcgcaa cgtacttgtc aatggcctga 153060 cgttcggtac cgccgttgat gcgaaccatc tgggctttat caccgtcgaa tcgcagcatc 153120 agagtgatat cgacagaagt tttcagttta tcttgagaag gaacttgtac gtttgagaat 153180 tccatcttca gatcacgagt tgaataggta tcaactgatg ccagcgggtt gatgatattc 153240 agaccgggct gcatgatatt cgggctaact ttacccagga aagtggtggt tgcaacggaa 153300 ccatcatcga ccacagtaaa gatattcagg gcagtaattg cggtcagcag accggctgcg 153360 atagaaaggc ccattttctt ggtaattttc ggagttttgg acatagtacg cattatattt 153420 ccttttgatt gaattagggt tttgcagtta cgatgatata gctttcatta cgatgagatt 153480 cggtgcgaat ctcatatcca agagttctta gatagtcgac gatatctctg gtgtaaattc 153540 cagggaattt atcgcccgcg aaggtgattg taaaaactcg ttttgaaatc atttcgtcgg 153600 caacgaattt tccaaccgga gctaatctgc gtttcaactc ttcagtttca aaagcttgag 153660 caagttgaac ttgggcaaaa acatcagaac ttttcataat gtgtttctca tttcgtttaa 153720 cttgaggata ttctatacaa aacaaccttg ttgtaaacat ctttttgaaa ttattttgaa 153780 gattttccca atgtccagtg tttacgacat actgaaatat agcgatcatt gccacctatc 153840 gaaacacttg gcccccacac tttcttgcca ttctcatcga ttctcatgtt cattgtagct 153900 ttggtgccac accaacatat ggttttgtgc tcaacctttt cttctgccaa aaccatcagt 153960 cgttctgctg ccggaaatat gttaccattt gaatcagaca acaatccata gcacattact 154020 ggaatgtcca gttcgtctac aacagccgca agctggctga cttgttctgg aagcagaaat 154080 tgcgcttcat ctaccaaaac acaactaatg tgctgcccat tatgctcttt gctgattaag 154140 gcggtcaaac tatcgctttg cctcaccata atagcaggcc gcgatatacc aattcttgag 154200 gatacggttg aaccatcacg cgtatcaatc gcaggcttta tgataatagt acgcatgtca 154260 cgttcttcgt aattgtgtgc tacttgaagc aaatgtgtgc ttttgccaga attcattgca 154320 gcatagtgaa aatgaagact tgccatttag acctcgttga gccgcttgaa aagcgcatag 154380 ttggtgtgat attcatcatt ggtaacttct tcgccgaacc agcacggtgg aatgaatgca 154440 ttggcatctt cgacgttatc aaattcgatc tcgatatact gttcaccaca agcaaacata 154500 tcgagttcga tcgttaatcc atgaccatgc gggatttcgt accgagtttt aacaacacaa 154560 gttggtaaac cggcagcatc atgggcttcc catgcagtat tcttgtcgat ttcgttttcg 154620 acctcttcgc gaaccaaacc ggcgccagtt ttcactgttt ctatgaattt ttcacgaacg 154680 ccagtttcca tcgcacttcg atagcgttta ccatcaaagt agaattgtgc aatttgctta 154740 tgaggaaact gctccaaatt cttgtatgga acaaatttaa caagccattt acgttctatt 154800 tctttagcca ttgttcttcc acttgtatgc aattgtagtc acttcatacg gttcgacttc 154860 actgacatcc atcagatcag gttcattttc ccaaatcggg ctgtcctgct cttctgttgc 154920 accgacttca tatggttcgc ggaaatagcg ctttactcca tccttttcaa aggagaaaac 154980 aaagtcgtaa taaacagtcc agcgcccgcg gtcgacaact tcgtttacta aagtttcata 155040 tttgccacac agttctgatg gaagaccttc tcctgggatg atttccagcg attcgccaat 155100 gagttcaatc aaaaattctt ttggaaattt cattacggca ccattgaggt ttgaccaata 155160 aacactcggc cgtggtacat caactcgtaa ttcacgagaa ctacatcgcc ggcgtcacga 155220 tatgagtgga ttataatacc tttacattct tcgccaagta attcgactat tgcacattcg 155280 aagatacggt tcatcaccgg accacactgt tgccatttac cgactgccat cgaattccac 155340 cactgtaata tcaatatttg gagttacttc gttgatgatt gcttcaattt tgccccaatc 155400 acctcgggca agaccagcac ctattttagg aatacacata gtcggcttac cgaggccaaa 155460 atcgacagtt tcttgacaca tagtgttcaa ggtttcaaag catgaacggg ccgcatcata 155520 ggacaacata tcgctagggt cccagtaagt cgcctgagta tagaagttga aggcaaggcc 155580 agcatagggg taacttgtgg ccgagatcgt tccaagcttg gaacgatcac cttcaactgt 155640 cttttgatcg agttcccaaa gctcagggag gcgttcacga acttctttag caatgccaga 155700 acccattcgg ttaaaaatgt tacaaccatg cgcaaacatg tcatattcgc cgttcagaaa 155760 cagactgatt gcattacctt tgactgtgtt aacgatcata atgtgaactc tcctttgccg 155820 taaggtgtag taattgacat aactttgcct atcgggttga aatcgggatt atctttacgc 155880 caaataacga tagcggagcc agtccgaaca tagtcaacgt tttgaacaac tccgtcgaag 155940 ctaatcataa ctcgctcaga cccagataaa atactgtcgt cagatcgtgc agagtcaatt 156000 atccaataat cactattgaa aataatccca aggcaatcgt cacgtttctg tgcgtattgc 156060 atatcacatg aaacggacag agcagattca tacgtgccat tttcatcggt gaattctttg 156120 attactccag atttttcagg aaaccagaac atttcgttca tgtttgctac tgcaggagcg 156180 gctgcgccgc aaccataaat tgacagtgct aaaacagctg ctattgactt tttcatattt 156240 caccctcttg tgcgagaaca tcattgaaat cataactctg gaagccgact ccactcgaat 156300 gagccaagtc ataacggtca tttccattgc tgtaatggat acgattgaat tcgatatcta 156360 cggcgtccac atatggacgc ccagcaataa caaaagatga tattgcgctt tacctcacaa 156420 acagtattcc cgaatgaatc tttcagtttc tatgcggact tcagacgagt taaaatcggt 156480 gtgaatcata attcgggaat cggtgtgaat cataatttgg gaatcgtggg aatcgcgagt 156540 aatcaaaaac tcgtatccaa tagattcttc tggcatagct acgttcatat cgtaaagtga 156600 attgaaaaat cggcaacctt ccaatttagc acgatcaact tcaacagcca caataaacgc 156660 gataccgaac ttattgatga tgaattccat aacttactcc acatttgatt ggtttgttta 156720 actgaggtta tagtatccca taacctcaaa aatgtaaaca tttatttgta aataaagtcc 156780 gtttgtttga gctcttgatt ttttgccaaa acacgatcgg catatctcaa accagcatgg 156840 taattccaac ctgcgttgta tgaagccaga gcaattcgaa tgttaccttt tcgaaccttg 156900 agccagtatg agagttcatc catagcccat tcggcagaag aacttttacg ctccaaatcc 156960 cttttcagat accaatgtct gtacggaatt cctctattgt cgagtttaga tgtaaccgtt 157020 gtgtaaagat tttgaaacat cccatacgcg tgatgaccct ttttatttct accagtgttt 157080 attccagctg aggattcttc ccatgcgata gcagcgaata atgtgccaag atgacgatcg 157140 ttccagaaat tcggattatt gacatctcgc aattctcccg tcaagtcata agcttttcca 157200 tagttgtaag catacgacaa attgtacttt tgagtgtccg taaaatctgt taccgacgga 157260 ccggcataaa catgtgtggc aaatacgatc atgagaatca tcaatagcct cataacccct 157320 ccattttaat gactttcgta gttacgtttg aagttaaacg tcgcgaattg actattgcca 157380 ttcggcaggt caaagaagaa ctgtattctg atgatggcgg aattttggaa ggagtaattc 157440 caatccaaag cgatccattg gtgatttcta agcgaattgg tcgatattcg acaccttcga 157500 ctcgtttttc gtcaagatgc ggaggatacg gaagagacat gtattcgtca acttcatgta 157560 ttttttcctt caagcctttg atcaagcaca gcgtatcatc gacattgata ttgcgaagca 157620 aaaggtcatc tatgaaatga taggtgtatt ctagatgaaa acggtggcca tgaccagaag 157680 ccaaccgagc ttcttcgatt tttctgttga tttctttaaa ctctgcttcg aggattctcc 157740 gaagtttgta gcgattcatg ataatactcc atatgttatt gattcaaact cattctaaca 157800 tggatttttc gtgatgtaca ccataaaatg aaaatgggct ccgaagagcc cattgttaaa 157860 ttcccatttt ttgcttcaat tctgcaatgt ttttcggaac tcccgtaaaa cgatcggttg 157920 tttctacatt aatcattgta ggcaaacccc gaattgcgta ttttgctgct agagctatgc 157980 cttcgtcaga atcgacatca atatatttat agtcaacgtt agcgagcata ggttttacga 158040 gtttgcagtt tgcacaccat tcagcgccga aaagataaat catttatttt tcccgtataa 158100 taagctattg cagcaattcc ttccaaaaca aagaaagaaa tcacagttga aagtaatacg 158160 tcaattatat acccaaatcc aaaaagcgga ttgacataga caaaaattgc gcataaaact 158220 agaagttgta tcaagccgat tccttattgg gcctcgaaag gcccataagt cattgattta 158280 aacggattat ccttcgcacg ccaaacaggt tgattcacca gttgaagctt ttactccacg 158340 ctcggaacgc aaataataaa gagatttcag acgagggtca tccataaacg ctctatgaac 158400 agacgcaacg actgattctt tttcatcggc agcgaagaac aaattgattg attgcgcttg 158460 gtcaatgtgc cgttgacgag ctgaagcaag acgtatgatt gcatgttggt caatctcata 158520 agctgttttg aacaccattt tctcatggtc tgtcaaaata tccagatgtt gaacagaacc 158580 attatgatag gtggcaatat tttccatgag gtctttgatt tctttatcag aaagacggtc 158640 ggacaatact ttagccaata ccgggttcga gcgaacaaaa tcaccagcat ttgactgttg 158700 gatgaagctg ttacatacga gaggctcaac accctgagat acaccaccag ccaatagagc 158760 agaactcata tttggagcaa tagtgatcaa agtagcatta cgcatacctg ttccaacaca 158820 ccattctggt tcaccatgct cttctgctaa ttcccgagaa gcagcttctg cataaacctt 158880 gatttgcgaa taaatgctat tgttcagaat gtgggcggcg ccggattcga acgcagtatc 158940 gttcatttgg agataggtat ggaaacccag agtaccaaga ccgagcgcac gtgctttttc 159000 ggtaaatctg atagctttat gaagagtgtc atacgggagt tttttcgctt tttccaagaa 159060 ttctgagcat accgaatcaa ggaaacgaac agcccatttg atatcttcag cactaatttc 159120 atcccaacga gccaaattca atgagctcag gatacaggta aaagtatgca tatcgtcaga 159180 tggcaatgcg atttcggtgc acagctggct tgaacgaata cggatacctg aatttttgat 159240 tgcttgcgga gcaagatcgt tagcaatcca gttcttccac atataaccct taccagtgcg 159300 ggcgcgcata tagagcagtt cattccagcg tgccatatat tcaggatcgc gagccagaag 159360 cttttcataa tcttctttct caaataccca accaacgtgt gcagaagctg ggtttttcag 159420 cacatacccc tgaagttccc agaaatcacc atgcgagaag tcaacgtaac cggcccattc 159480 accacgtcgg ccagcagctg caacctttgt tttggtgtta acgaagttgt caaatacagg 159540 aacgagtccg tctgctttgt tgtggctggt cgagatatcg gatccacgag gccggatgtc 159600 tccaagatat gacgcagttc cgaaaccgtt tttagcgagc attgcgactt ctgtttggcc 159660 ttcgtagaag tcaaggacac tgtccccaac ataacttcct gcacaggaaa caggcattcc 159720 acgatctgtg ccggtgttac agaaaactgg ggtagccatc gccagcttac cggaccagag 159780 aaggtcgaaa tagcgctctt cagcttctgg tcggatatca tgctttgcaa gtgttgaagc 159840 gactcgcctg aatgcaccac gaacggtttc tcctttgtac tgataatttt tcaggaacat 159900 tgaataacct tgtgtggtga accactctgg catttcacca attgactgca tatgtttgcg 159960 ttcggctgac aaagattcga attttgaaat tttagacatt aaagcacctt gattttaaaa 160020 gattgccctg gtttaccagg gcagaattat tttaccagca atcagagaaa ccttctcggt 160080 tccaattgat attgtattcc gaacctgagc cagtgaagaa atcatggaat ttcttggcat 160140 taatggtgcg atagaaccaa tcagcgatag ggttattttc gatttcgaaa atgggctcat 160200 aaccaagatt ttcaagacaa agattaattc gagatttgac aaaaactcgt agctcgtcag 160260 cagttatacc gtcgatcggt tcagcgaaaa cgagatcgat aatgccagac tcgtgatcaa 160320 atacttgacg tgccatgttg ataatgtcat ttttcagttt tgcccgaaca tcttcgccgt 160380 atttttcttt catttcgcgg cacagtgttt gaaacaacat cgcaccgcca atcgagtggt 160440 gatgctcatc agcaaccgaa aggtcaacgc cgcgacaaat atttcgcatc aaatcttttc 160500 cgcactcttg ggcttggaaa tgcttgagga atgcgaaact ggaataaaga acggcacctt 160560 caataaatgt gaaagctgca aaagatttgg cgtcatcggg gtcattgact gatttaccaa 160620 caaattgaat acgacgagat agttcctcgc tttctttcca agaagtgtag aaagcctcgt 160680 catccagata aagaacttca ttgactttgt tataaaaagg tgcatgagaa ttaccttcta 160740 cggcagcaaa tagagttgcc atgcgattga tttcaggacg accgaatgtt cgagcgattc 160800 gggctgacca ataatcttca ccgactttgc gctcgtaaat tgtaaacagt ttaagaacag 160860 ttgtaatacc attcaactca ccaagtgtca attttgtgcg cagatcttga gcatcattat 160920 caacaaccgg ttcatcccat ggccaaaaag catgcatttg ctcatccgcc aatttggcaa 160980 actcggggta tttgataatc caaccttctt ggctttgata cattggaagg gttttataaa 161040 gttcgtacat ttaaaatcct ataagatttc tcaatttttg gacataaccg tcgcattgtt 161100 cgaggtaata cgccgtaaat tcagtagatt ttgaaaaccc agtctttgaa aataaagcag 161160 tgcgtatgct ctctacattg gcagaagtta caaatatgat tactggaggc ctatgcaaaa 161220 gctcaaaatg cattttatct ttgcaaaatg acaaagtatc taacattttc ggtttatcac 161280 atgcatgcca tatgtcatgt gcaatatctc tgtctgctac gatcagcgct cctccaggta 161340 gttgatcgta agataattta tgcatcaaac tggccgtata aattacgccc gatgttttaa 161400 caactttgat tgggtcatct gcactatcgc gattgtagtg ctcagtcatt atgtctttta 161460 gcatagtgaa aaataagcgt taaggccgct tactccaatt cgattacttt tgcttccaga 161520 accaaagtgt cattgactgg aaatttggta tttgtgggaa tcattgggtc atgactctca 161580 ataacattga aataatgacc agatttctga gcaacgattt taccaaaacc gaaatcgata 161640 gtgtgagtag ctttagacat ttttaatcct tgtaatgtgt gtttatttga tatggcaata 161700 ataacactag gcttgaataa tttaacagac tgcatcaagt ttttagtaca aattcggcat 161760 ttactaattt tgcccatttg taaaaatcgt gcaccctgtt ctcatcaaag agaataaatt 161820 cgctctcgtc aaccatgatg aattgaattt tttctaaatc cagaatctgc aattgtctct 161880 taatatcatt aaaagtcaga atatcgaatt tagctcccat acttttggtc attttcttat 161940 tttgggtgtt catgactacc attgcgactt tggcatgatt gcttaattcg ttaccaagcc 162000 tgataaatga agttgtttta ccggtttgcc gaccaacatt tatggatatt gttctattcg 162060 attttaaaaa atctgatcga tctttcaata cctccatctc gcaccccggt gggtaattga 162120 ccgaaacaac acgcattgca tttacgaaga aagagttata atcgaaatat ttgttcatgt 162180 tgaaacctcg tcgagagaat acgaaaaggg ctcccgaagg agccctaatt atgattgacg 162240 cttaattcgc cgttttagca tatcgtaata cctgtccatc gcgatatact gttgttccat 162300 gagaaacttc tcatcaggat caagagtctt gtaaatatca gacatgttaa tgaaatcgtt 162360 gagcttattc agtcgaacac ccaattcact cagctcatct ttcatacgtt gtaaatgaga 162420 catattaatt accttaataa attgatctga gcaattcctg ttgacgcctg cgaagcttct 162480 gttcatcagt taattgatct tctggaattt gttcttttac tactccgggt tttctatttg 162540 ggccggtgtt tttccacaat ggagaattat accaattctc gcttcgtgca tttccactgc 162600 cccttccctc tcgggcatga gatttttcgt gcatcatcgc catgacatca cctttaattt 162660 ggcagtccct attggatttg aaccaatgac ccgcggctta gaaggccgct gctctatcca 162720 actgagctaa gagaccatat gactaaaaag ccgcaatcaa gcggcttgga gtttatctcg 162780 aatacgatac agatttgaac aaaattcttg ttcagttaac actgtttcat tctttttact 162840 tttacccatt gaatgggtta acgaagaatt ccgggtggct agg 162883

Claims (7)

  1. 에로모나스 살모니시다 균을 특이적으로 사멸시킬 수 있는 능력을 갖고 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는, 자연으로부터 분리된 미오비리대 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP).
  2. 제1항의 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP)을 유효성분으로 포함하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증의 감염 방지용 또는 감염 치료용 조성물.
  3. 제2항에 있어서, 상기 조성물은 약욕제 또는 사료첨가제 형태로 사용되는 것을 특징으로 하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증의 감염 방지용 또는 감염 치료용 조성물.
  4. 제2항에 의한 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP)을 유효성분으로 포함하는 조성물에 사람을 제외한 동물을 담그는 처치를 실시하는 단계를 포함하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증을 방지 또는 치료하는 방법.
  5. 제4항에 있어서, 상기 조성물이 약욕제 형태인 것을 특징으로 하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증을 방지 또는 치료하는 방법.
  6. 제2항에 의한 박테리오파지 Aer-SAP-1(수탁번호 KCTC 12814BP)을 유효성분으로 포함하는 조성물을 사람을 제외한 동물에 투여하는 단계를 포함하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증을 방지 또는 치료하는 방법.
  7. 제6항에 있어서, 상기 조성물이 사료첨가제 형태인 것을 특징으로 하는, 에로모나스 살모니시다 균에 의해 유발되는 에로모나스 감염증을 방지 또는 치료하는 방법.
KR1020150149869A 2015-10-28 2015-10-28 신규한 에로모나스 살모니시다 박테리오파지 Aer-SAP-1 및 이의 에로모나스 살모니시다 균 증식 억제 용도 KR101723827B1 (ko)

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PCT/KR2016/010957 WO2017073916A1 (ko) 2015-10-28 2016-09-30 신규한 에로모나스 살모니시다 박테리오파지 Ａｅｒ-ＳＡＰ-1 및 이의 에로모나스 살모니시다 균 증식 억제 용도

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KR101859974B1 (ko) 2017-06-21 2018-05-21 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-2 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
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KR101875565B1 (ko) * 2017-08-22 2018-07-06 주식회사 인트론바이오테크놀로지 신규한 에로모나스 살모니시다 박테리오파지 Ａｅｒ-ＳＡＰ-2 및 이의 에로모나스 살모니시다 균 증식 억제 용도
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KR101859974B1 (ko) 2017-06-21 2018-05-21 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-2 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
KR101859973B1 (ko) 2017-06-21 2018-05-21 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-1 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
WO2018236085A1 (ko) * 2017-06-21 2018-12-27 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-1 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
WO2018236086A3 (ko) * 2017-06-21 2019-03-28 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-2 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
KR101875565B1 (ko) * 2017-08-22 2018-07-06 주식회사 인트론바이오테크놀로지 신규한 에로모나스 살모니시다 박테리오파지 Ａｅｒ-ＳＡＰ-2 및 이의 에로모나스 살모니시다 균 증식 억제 용도
WO2019039781A3 (ko) * 2017-08-22 2019-06-27 주식회사 인트론바이오테크놀로지 신규한 에로모나스 살모니시다 박테리오파지 ａｅｒ-ｓａｐ-2 및 이의 에로모나스 살모니시다 균 증식 억제 용도
KR102012227B1 (ko) * 2018-02-23 2019-08-21 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 Aer-HYP-3 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
WO2019164195A1 (ko) * 2018-02-23 2019-08-29 주식회사 인트론바이오테크놀로지 신규한 에로모나스 하이드로필라 박테리오파지 aer-hyp-3 및 이의 에로모나스 하이드로필라 균 증식 억제 용도
CN111742046A (zh) * 2018-02-23 2020-10-02 尹特荣生物科技株式会社 新型嗜水气单胞菌噬菌体Aer-HYP-3及其在抑制嗜水气单胞菌细菌生长方面的用途
US11844818B2 (en) 2018-02-23 2023-12-19 Intron Blotechnology, Inc. Aeromonas hydrophila bacteriophage Aer-HYP-3 and use thereof for inhibiting growth of Aeromonas hydrophila bacteria

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