KR101592177B1 - 대장균에 대한 광범위 항균 활성을 갖는 박테리오파지를 활용한 대장균 감염을 방지 및 처치하는 방법 - Google Patents
대장균에 대한 광범위 항균 활성을 갖는 박테리오파지를 활용한 대장균 감염을 방지 및 처치하는 방법 Download PDFInfo
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Abstract
본 발명은 대장균에 대한 광범위 항균 활성을 갖는 자연으로부터 분리된 박테리오파지인 박테리오파지 EK88P-1을 유효성분으로 포함한 조성물, 및 본 조성물을 이용한 대장균의 감염을 방지 및 처치하는 방법에 관한 것이다. 본 발명에 따른 조성물의 유효성분인 박테리오파지 EK88P-1은 대장균에 대한 광범위 항균 활성을 갖고, 유전체의 특징으로 서열번호 1 내지 25로 특징지어지는 부분서열을 가지며, 약 49 kDa, 53 kDa, 94 kDa, 및 103 kDa 크기의 주요 구조 단백질을 가지며, 형태학적으로 미오비리대에 속하는 박테리오파지인 것을 특징으로 한다.
Description
본 발명은 대장균에 대한 광범위 항균 활성을 갖는 자연으로부터 분리된 박테리오파지를 유효성분으로 포함한 대장균의 감염을 방지하거나 처치하는 데에 활용될 수 있는 조성물 및 이 조성물을 이용한 대장균의 감염을 방지 및 처치하는 방법에 관한 것으로, 더욱 상세하게는 유전체의 특징으로 서열번호 1 내지 25로 특징지어지는 부분서열을 가지는 박테리오파지, 및 상기 박테리오파지를 유효성분으로 포함하는 대장균의 감염 방지 및 감염 후 처치 목적으로 활용될 수 있는 조성물 및 이 조성물을 이용한 대장균의 감염 방지 및 감염 후 처치 방법에 관한 것이다.
대장균은 간균에 속하는 장내세균으로 그람 음성균에 속하며, 대부분의 대장균은 상재균으로 병원균이 아니나, E. coli O157:H7이나 장내독소형 대장균 (ETEC, enterotoxigenic E. coli) 등은 병원성 대장균으로서 사람에게서 식중독을 유발하거나, 소, 돼지, 염소 등의 여러 동물들에서 설사를 일으킨다. 병원성 대장균은 60℃에서 10분간 가열했을 때 활성을 잃는 이열성독소 (heat-labile enterotoxin, LT)나 100℃에서 30분간 가열해도 저항성을 나타내는 내열성독소 (heat-stable enterotoxin, ST)를 생산할 수 있다.
병원성 대장균 중에 장내독소형 대장균은 동물에서도 심각한 문제를 초래하는데, 신생자돈이나 이유자돈에서의 설사증은 축산산업에서 큰 문젯거리다. 그 중에서도 K88형 대장균, K99형 대장균, 987P형 대장균 및 F41형 대장균이 주요 장내독소형 병원성 대장균의 형태로 알려져 있다.
이러한 병원성 대장균의 폐해로 이의 감염을 방지할 수 있고 또한 이들의 감염을 효과적으로 처치할 수 있는 방법의 개발이 절실하다 할 수 있다. 이러한 병원성 대장균의 감염 방지나 처치 목적으로 다양한 항생제들이 사용되어 왔으나 최근 항생제 내성균의 발생이 증가함에 따라 항생제 외의 다른 효과적 방안의 확보가 시급한 실정이다.
최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 자연친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 박테리오파지는 세균에 감염하는 아주 작은 미생물로서 보통 파지(phage)라고 줄여서 부르기도 한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다.
박테리오파지는 1915년 영국의 세균학자 Twort가 포도상구균(Micrococcus) 집락이 어떤 것에 의해 투명하게 녹는 현상에 대한 연구에서 발견되었다. 또한, 1917년에는 프랑스의 세균학자 d'Herelle이 이질환자 변의 여과액 중에 적리균(Shigella disentriae)을 녹이는 작용을 가진 것이 있다는 것을 발견하고 이에 대한 연구를 통해 독립적으로 박테리오파지를 발견하였으며, 세균을 잡아먹는다는 뜻에서 박테리오파지라고 명명하였다. 이후 이질균, 장티푸스균, 콜레라균 등 여러 병원성 박테리아에 대한 박테리오파지가 계속적으로 발견되었다.
박테리아를 사멸시킬 수 있는 특별한 능력으로 인하여 박테리오파지는 발견 이후부터 박테리아 감염에 대응하는 효과적 방안으로 기대를 모았으며 관련하여 많은 연구들이 있었다. 그러나 Flemming에 의해 페니실린이 발견된 이후, 항생제의 보급이 일반화되면서 박테리오파지에 대한 연구는 일부 동유럽 국가들 및 구소련에 한정되어서만 명맥이 유지되었다. 그런데 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
특히 최근 항생제 사용에 대한 정부 차원의 규제가 전 세계적으로 강화됨에 따라 박테리오파지에 대한 관심이 더욱 높아지고 있다.
이에, 본 발명자들은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖는 자연으로부터 분리된 박테리오파지를 이용하여 대장균의 감염을 방지 또는 처치하는 데에 활용될 수 있는 조성물을 개발하고, 또 이 조성물을 이용하여 대장균의 감염을 방지 또는 처치하는 방법을 개발하고자 노력한 끝에, 이에 적합한 대장균에 대하여 광범위한 항균 활성을 갖는 박테리오파지를 자연으로부터 분리하고, 이 분리된 박테리오파지를 타 박테리오파지와 구별하여 특정 지을 수 있도록 유전체의 부분서열을 확보하고, 이 분리된 박테리오파지를 유효성분으로 한 조성물을 개발한 다음 이 조성물이 대장균의 감염 방지 및 처치에 효과적으로 활용될 수 있음을 확인함으로써 본 발명을 완성하였다.
따라서 본 발명의 목적은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖는 신규 분리된 박테리오파지를 제공하는 것이다.
본 발명의 또 다른 목적은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖는 신규 분리된 박테리오파지를 유효성분으로 포함하는 대장균의 감염을 방지하는 데에 활용 가능한 조성물 및 이 조성물을 이용한 대장균의 감염 방지 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖는 신규 분리된 박테리오파지를 유효성분으로 포함하는 대장균의 감염을 처치하는 데에 활용 가능한 조성물 및 이 조성물을 이용한 대장균의 감염 처치 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 조성물들을 이용한 대장균 감염 방지 및 처치 목적의 소독제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 조성물들을 이용한 대장균 감염 방지 및 처치 목적의 음수첨가제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 조성물들을 이용한 대장균 감염 방지 및 처치 목적의 사료첨가제를 제공하는 것이다.
본 발명은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖는 자연으로부터 분리된 박테리오파지를 유효성분으로 포함하는 조성물, 및 이 조성물을 이용한 대장균의 감염 방지 및 처치 방법을 제공한다.
본 발명의 조성물의 유효성분으로 포함되는 분리 박테리오파지는 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 갖고, 유전체의 특징으로 서열번호 1 내지 25로 특징지어지는 부분서열을 갖는 것을 특징으로 하는 박테리오파지 EK88P-1이다. 박테리오파지 EK88P-1은 본 발명자들에 의해 분리된 후 2014년 4월 10일자로 한국생명공학연구원 생물자원센터에 기탁되었다 (기탁번호 KCTC 12574BP).
또한, 본 발명은 대장균의 감염을 방지 또는 처치하는 데에 활용될 수 있는 소독제, 음수첨가제, 및 사료첨가제를 제공한다.
본 발명의 조성물에 포함되는 박테리오파지 EK88P-1은 K88형 대장균을 포함하여 다양한 대장균에 대하여 광범위한 항균 활성을 가지므로 K88형 대장균을 포함하여 다양한 대장균에 의해 유발되는 다양한 질환의 예방(감염 방지)이나 치료(감염 처치)에 효과를 나타낸다. 따라서 본 발명의 조성물은 K88형 대장균을 포함하여 다양한 대장균에 의해 유발되는 질환에 대한 예방 및 치료 목적으로 활용될 수 있다. 본 명세서에서의 K88형 대장균을 포함하여 다양한 대장균에 의해 유발되는 질환이란 K88형 대장균을 포함하여 다양한 대장균 감염에 의해 폐사, 설사 및 성장 저하 등을 수반하는 증상을 총칭한다.
본 명세서에서 사용된 “처치” 또는 “치료”라는 용어는 (ⅰ) K88형 대장균을 포함하여 다양한 대장균에 의해 유발된 질환의 억제; 및 (ⅱ) K88형 대장균을 포함하여 다양한 대장균에 의해 유발된 질환의 경감을 의미한다.
본 명세서의 “분리” 또는 “분리된”은 자연 상태로부터 여러 실험 기법을 활용하여 박테리오파지를 분리하는 것과 타 박테리오파지와 구별하여 특정 지을 수 있는 특징들을 확보하는 일을 지칭하며, 이에 더하여 생물공학기술로 박테리오파지를 산업적으로 활용할 수 있게끔 증식시키는 것도 포함한다.
본 발명의 박테리오파지는 박테리오파지 EK88P-1과 이의 변형체들(variants)을 포함한다. 본 명세서의 “변형체”란 유전체 서열(genomic sequence)이나 유전정보가 코딩(coding)하고 있는 폴리펩타이드(polypeptide)에서의 작은 변이(minor variation)가 있지만 전체적 유전자형(genotypic) 및 표현형(phenotypic) 특징이 박테리오파지 EK88P-1과 같은 박테리오파지들을 의미한다. 상기 변형체에는 다변형성 변형체(polymorphic variants)도 당연히 포함된다. 이러한 변형체들은 박테리오파지 EK88P-1과 같은(same) 또는 동등한(equivalent) 생물학적 기능(biological function)을 가지는 것이 바람직하다.
본 발명의 조성물에 포함되는 약제학적으로 허용되는 담체는 제제 시에 통상적으로 이용되는 것으로서, 글루코스, 말토덱스트린, 락토오스, 덱스트로오스, 수크로오스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산칼슘, 알기네이트, 젤라틴, 규산칼슘, 미세결정성 셀룰로오스, 폴리비닐피롤리돈, 셀룰로오스, 물, 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘 및 미네랄 오일 등을 포함하나, 이에 한정되는 것은 아니다. 본 발명의 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다.
본 발명의 조성물에는 박테리오파지 EK88P-1 또는 이의 변형체들이 유효성분으로 포함된다. 이때 포함되는 박테리오파지 EK88P-1 또는 이의 변형체들은 1× 101 pfu/㎖ 내지 1× 1030 pfu/㎖ 또는 1× 101 pfu/g 내지 1× 1030 pfu/g로 포함되며, 바람직하게는 1× 104 pfu/㎖ 내지 1× 1015 pfu/㎖ 또는 1× 104 pfu/g 내지 1× 1015 pfu/g로 포함된다.
본 발명의 조성물은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 약학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화 됨으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수도 있다. 이때 제형은 오일 또는 수성 매질 중의 용액, 현탁액 또는 유화액 형태이거나 엑스제, 분말제, 과립제, 정제 또는 캡슐제 형태일 수도 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수도 있다.
본 발명의 조성물은 활용 방식에 따라, 이에 국한되지 않지만, 소독제, 음수첨가제, 및 사료첨가제로 구현될 수 있다.
본 발명의 조성물 및 이 조성물을 이용한 K88형 대장균을 포함하여 다양한 대장균의 감염 방지 및 처치 방법은 기존의 항생제 등의 화학물질에 기반을 둔 방식에 비하여 K88형 대장균을 포함하여 다양한 대장균에 대한 특이성이 매우 높다는 장점을 제공할 수 있다. 이는 다른 유용한 상재균에는 영향을 주지 않으면서도 K88형 대장균을 포함하여 다양한 대장균의 감염 방지 또는 처치 목적으로 사용할 수 있음을 의미하며, 이의 사용에 따른 부작용이 매우 적다. 통상적으로 항생제 등의 화학물질을 사용하면 일반 상재균들도 피해를 함께 입게 되어 결과적으로 동물의 면역력 저하 등을 초래하여 다양한 부작용이 나타난다. 한편, 본 발명은 자연계에 이미 존재하는 박테리오파지를 분리하여 조성물의 유효성분으로 사용하기 때문에 매우 자연 친화적이라는 장점 또한 제공할 수 있다.
도 1은 박테리오파지 EK88P-1의 전자현미경 사진이다.
도 2는 박테리오파지 EK88P-1의 주요 구조 단백질을 일차원 전기영동법으로 분석한 결과이다. 레인 M은 단백질 크기 마커이며, 레인 1은 박테리오파지 EK88P-1의 단백질 시료이다. 주요 구조 단백질을 *로 표시하였다.
도 3은 박테리오파지 EK88P-1의 유전체를 주형으로 한 중합효소연쇄반응의 결과를 보여주는 결과이다. 레인 1은 서열번호 26 및 서열번호 27을 사용한 중합효소연쇄반응 결과이고, 레인 2는 서열번호 28 및 서열번호 29를 사용한 중합효소연쇄반응 결과이고, 레인 3은 서열번호 30 및 서열번호 31을 사용한 중합효소연쇄반응 결과이고, 레인 4는 서열번호 32 및 서열번호 33을 사용한 중합효소연쇄반응 결과이고, 레인 5는 서열번호 34 및 서열번호 35를 사용한 중합효소연쇄반응 결과이고, 레인 M은 DNA 크기 마커이다.
도 4는 박테리오파지 EK88P-1의 대장균에 대한 사멸능을 보여주는 대표적 실험 결과이다. 맑게 생긴 투명한 원은 배양 접시 위에 자란 대장균이 용균되어 결과적으로 형성된 용균반이다.
도 2는 박테리오파지 EK88P-1의 주요 구조 단백질을 일차원 전기영동법으로 분석한 결과이다. 레인 M은 단백질 크기 마커이며, 레인 1은 박테리오파지 EK88P-1의 단백질 시료이다. 주요 구조 단백질을 *로 표시하였다.
도 3은 박테리오파지 EK88P-1의 유전체를 주형으로 한 중합효소연쇄반응의 결과를 보여주는 결과이다. 레인 1은 서열번호 26 및 서열번호 27을 사용한 중합효소연쇄반응 결과이고, 레인 2는 서열번호 28 및 서열번호 29를 사용한 중합효소연쇄반응 결과이고, 레인 3은 서열번호 30 및 서열번호 31을 사용한 중합효소연쇄반응 결과이고, 레인 4는 서열번호 32 및 서열번호 33을 사용한 중합효소연쇄반응 결과이고, 레인 5는 서열번호 34 및 서열번호 35를 사용한 중합효소연쇄반응 결과이고, 레인 M은 DNA 크기 마커이다.
도 4는 박테리오파지 EK88P-1의 대장균에 대한 사멸능을 보여주는 대표적 실험 결과이다. 맑게 생긴 투명한 원은 배양 접시 위에 자란 대장균이 용균되어 결과적으로 형성된 용균반이다.
이하, 실시예에 의거하여 본 발명을 보다 구체적으로 설명하지만, 이들 실시예는 본 발명의 예시일 뿐이며 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.
실시예 1: 대장균을 사멸시킬 수 있는 박테리오파지의 분리
대장균을 사멸시킬 수 있는 박테리오파지의 선별에는 자연 환경으로부터 확보된 시료들을 이용하였다. 한편, 박테리오파지 분리에 사용된 대장균은 본 발명자들에 의해 미리 분리되어 K88형 대장균으로 동정(identification)된 것이다.
박테리오파지 분리 과정을 상세히 설명하면, 수집된 시료를 대장균을 1/1000 비율로 접종한 TSB(Tryptic Soy Broth) 배지(Pancreatic Digest of casein, 17 g/L; Papaic Digest of Soybean, 3 g/L; Dextrose, 2.5 g/L; Sodium Chloride, 5 g/L; Dipotassium Phosphate, 2.5 g/L)에 함께 첨가한 다음 37℃에서 3-4시간동안 진탕배양 하였다. 배양 후, 8,000 rpm에서 20분간 원심분리하여 상등액을 회수하였다. 회수된 상등액에 대장균을 1/1000 비율로 접종한 다음 37℃에서 3-4시간동안 또 다시 진탕배양 하였다. 박테리오파지가 시료에 포함되어 있었을 경우 박테리오파지의 수(titer)가 증가될 수 있도록 이러한 과정을 총 5회 반복하였다. 5회 반복 후에 배양액을 8,000 rpm에서 20분간 원심분리 하였다. 원심분리 후, 회수된 상등액을 0.45 ㎛의 필터를 이용하여 여과를 해 주었다. 얻어진 여과액을 사용한 통상의 점적 실험(spot assay)을 통하여 대장균을 사멸시킬 수 있는 박테리오파지가 있는지를 조사하였다.
상기 점적 실험은 다음과 같이 실시되었다. TSB 배지에 대장균을 1/1000 비율로 접종한 다음 37℃에서 한밤동안 진탕배양 하였다. 이렇게 하여 준비된 대장균의 배양액 2 ml (OD600이 2.0)을 TSA(Tryptic Soy Agar) 평판배지(Pancreatic Digest of casein, 17 g/L; Papaic Digest of Soybean, 3 g/L; Sodium Chloride, 5 g/L; Agar, 15 g/L)에 도말(spreading)하였다. 도말한 평판 배지를 클린벤치(clean bench)에서 약 30분 정도 방치하여 도말액이 건조되게 하였다. 건조 후 앞에서 준비한 여과액 10 μl를 대장균이 도말된 평판 배지 위에 점적하였다. 이를 30분 정도 방치하여 건조시켰다. 건조 후 점적한 평판 배지를 37℃에서 하루 정치 배양한 다음 여과액이 떨어진 위치에 투명환(clear zone)이 생성되는가를 조사하였다. 투명환이 생성되는 여과액의 경우가 대장균을 사멸 시킬 수 있는 박테리오파지가 포함되어 있다고 판단할 수 있다. 이러한 조사를 통하여 대장균에 대한 사멸능을 가진 박테리오파지를 포함한 여과액을 확보할 수 있었다.
대장균에 대한 사멸능을 가진 박테리오파지의 존재가 확인된 여과액을 이용하여 순수 박테리오파지의 분리를 실시하였다. 순수 박테리오파지의 분리에는 통상의 용균반 분석(plaque assay)을 이용하였다. 이를 자세히 설명하면, 용균반 분석에서 형성된 용균반 하나를 멸균된 팁을 이용하여 회수한 다음 이를 대장균 배양액에 첨가해 주어 37℃에서 4-5 시간 동안 함께 진탕 배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액에 50분의 1의 부피로 대장균 배양액을 첨가해 준 다음 다시 37℃에서 4-5 시간 진탕 배양해 주었다. 박테리오파지의 수를 증가시키기 위하여 이러한 과정을 최소 5회 이상 실시한 다음 최종적으로 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액을 사용하여 다시 용균반 분석을 실시하였다. 통상 순수 박테리오파지의 분리가 상기 과정의 1회로 달성되지 않기 때문에 이때 형성된 용균반을 이용하여 앞 단계를 전체적으로 다시 반복하였다. 이와 같은 과정을 최소 5회 이상 실시하여 순수한 박테리오파지를 포함한 용액을 확보하였다. 통상적으로 순수 박테리오파지의 분리는 형성된 용균반의 크기 및 모양이 모두 유사하게 될 때까지 반복하였다. 그리고 최종적으로는 전자현미경을 통하여 박테리오파지의 순수 분리 여부를 확인하였다. 전자현미경 조사에서 순수 분리가 확인될 때까지 앞에 기술한 과정을 반복하였다. 전자현미경 조사는 통상의 방법에 따라 실시하였다. 이를 간단히 설명하면 다음과 같다. 순수한 박테리오파지를 포함한 용액을 구리 격자(copper grid)에 묻히고 2% 유라닐 아세테이트(uranyl acetate)로 역염색법(negative staining)과 건조를 수행한 후 투과전자현미경을 통하여 그 형태를 촬영하였다. 박테리오파지의 전자현미경 사진이 도 1에 제시되어 있다. 형태적 특징으로 판단할 때 미오비리대(Myoviridae) 박테리오파지라고 확인하였다.
이런 방식으로 확인된 순수 박테리오파지를 포함한 용액은 다음의 정제 과정을 거쳤다. 순수 박테리오파지를 포함한 용액 전체 부피의 50분의 1의 부피로 대장균 배양액을 첨가해 준 다음 다시 37℃에서 4-5 시간 진탕 배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 충분한 수의 박테리오파지가 포함된 액을 얻기 위해 이러한 과정을 총 5회 반복하였다. 최종 원심분리로 얻어진 상등액을 0.45 μm의 필터를 이용하여 여과한 다음 통상의 폴리에틸렌 글리콜(Polyethylene Glycol; PEG) 침전 과정을 실시하였다. 구체적으로, 여과액 100 ml에 10% PEG 8000/0.5 M NaCl이 되게 PEG와 NaCl을 첨가한 다음 4℃에서 2-3시간 동안 정치한 후, 8,000 rpm에서 30분간 원심분리하여 박테리오파지 침전물을 얻었다. 이렇게 얻어진 박테리오파지 침전물을 완충액(buffer; 10 mM Tris-HCl, 10 mM MgSO4, 0.1% Gelatin, pH 8.0) 5 ml로 부유시켰다. 이를 박테리오파지 부유액 또는 박테리오파지 액이라 지칭한다.
이렇게 하여 정제된 순수 박테리오파지를 확보할 수 있었고, 이 박테리오파지를 박테리오파지 EK88P-1로 명명한 뒤, 2014년 4월 10일자로 한국생명공학연구원 생물자원센터(기탁번호 KCTC 12574BP)에 기탁하였다.
실시예 2: 분리 박테리오파지의 주요 구조 단백질 분석
얻어진 박테리오파지의 주요 구조 단백질을 일차원 전기영동을 통하여 확인해 보았다. 이를 위해 박테리오파지의 겉 외곽을 구성하는 단백질을 획득하기 위해 실시예 1에서 얻어진 박테리오파지 부유액 200 μl와 아세톤 800 μl를 섞어 격렬히 혼합한 후 10분간 -20℃에 정치시켰다. 그 다음 4℃에서 13,000 rpm으로 20분간 원심분리를 실시한 후 상층액을 제거한 다음, 자연 건조(air dry)시켰다. 이를 5배로 농축된 전기영동용 시료 완충액(5× 샘플 버퍼)을 50 μl 가하여 부유시킨 다음 5분 정도 끓여 주었다. 이렇게 준비된 시료를 일차원 전기영동을 통하여 분석해보았다. 그 결과, 도 2에서 알 수 있듯이 약 49 kDa, 53 kDa, 94 kDa, 및 103 kDa 크기의 주요 구조 단백질들이 확인되었다.
실시예 3: 박테리오파지 EK88P-1의 유전체 분리 및 특성 분석
박테리오파지 EK88P-1의 유전체를 다음과 같이 분리하였다. 유전체 분리에는 실시예 1에서와 같은 방법으로 얻어진 박테리오파지 부유액을 이용하였다. 먼저 부유액에 포함되어 있을 수 있는 대장균의 DNA와 RNA를 제거하기 위해, 박테리오파지 부유액 10 ml에 DNase I과 RNase A를 각각 200 U씩 첨가한 다음 37℃에서 30분간 방치하였다. 30분 방치 후에 DNase I과 RNase A의 활성을 제거하기 위해, 0.5 M 에틸렌디아민테트라아세트산(ethylenediaminetetraacetic acid; EDTA) 500 μl를 첨가한 다음 다시 10분간 정치시켰다. 그리고 이를 추가로 10분간 65℃에 정치시킨 다음 박테리오파지 외벽을 와해시키기 위해 proteinase K (20 ㎎/ml) 100 μl를 첨가한 후 37℃에서 20분간 반응시켰다. 그 후 10% 도데실 황산 나트륨염(sodium dodecyl sulfate; SDS) 500 μl를 첨가한 다음 다시 65℃에서 1시간 동안 반응시켰다. 1 시간 반응 후, 이 반응액에 25:24:1의 구성비를 갖는 페놀(phenol) : 클로로포름(chloroform) : 이소아밀알코올(isoamylalcohol)의 혼합액 10 ml를 첨가해 준 후 잘 섞어 주었다. 그리고는 이것을 13,000 rpm에서 15분간 원심분리하여 층이 분리되게 한 다음 분리된 층들 중에서 위층을 취하여 여기에 1.5 부피비의 이소프로판 알코올(isopropyl alcohol)을 첨가한 다음 13,000 rpm에서 10분간 원심분리하여 유전체를 침전시켰다. 침전물을 회수한 후 침전물에 70% 에탄올(ethanol)을 첨가한 다음 다시 13,000 rpm에서 10분간 원심분리하여 침전물의 세척을 실시하였다. 세척된 침전물을 회수하고 진공 건조 시킨 다음 100 μl의 물에 녹였다. 상기 과정을 반복하여 박테리오파지 EK88P-1의 유전체를 다량 확보하였다. 이렇게 얻어진 유전체를 이용하여 서울대학교 농생명과학공동기기원(National Instrumentation Center for Environmental Management)에서 차세대 염기서열 분석(Next Generation Sequencing; NGS) 방법을 통하여 박테리오파지 EK88P-1의 유전체 서열분석을 실시하였다. 이를 간략히 설명하면, 슬라이드 위에 DNA 단편을 고정시킨 후에 브릿지 증폭을 통해 최대 1,000 분자까지 증폭시켜 같은 서열의 DNA 단편 집단(cluster)을 형성시킨 다음 이 클러스터를 주형으로 네 종류의 형광 표식 염기를 사용한 일 염기 합성반응인 SBS(Sequence by Synthesis)를 수행하였다. 이 방법의 특징은 DNA 서열을 다른 기법들처럼 용액 안에서 증폭시키는 것이 아니라 판 위에 고정시킨 후에 판 위에서 구부러지면서 증폭되어 서열집단을 형성한다는 것이다. 그렇게 형성된 클러스터는 집단 별로 sequencing이 이루어져 각 read의 염기서열 정보로 전환되고 분석과정에 넘어간다. 확보된 유전자 서열을 이용하여 일반적인 방법으로 다양한 크기의 콘티그(contig) 25개를 확보하였다. 최종적으로 확인된 박테리오파지 EK88P-1의 콘티그 서열들은 서열목록 1 내지 25에 제시되어 있다. 이들 서열은 박테리오파지 EK88P-1의 전체 유전체 서열을 구성하는 부분 서열(partial sequence)들이라 할 수 있다. 이러한 부분 서열로도 박테리오파지 EK88P-1을 다른 박테리오파지와 구별하여 특정지을 수 있다.
실시예 4: 중합효소연쇄반응을 이용한 박테리오파지 EK88P-1의 유전체 특징 분석
분리된 박테리오파지 EK88P-1의 유전체 특징을 규명하기 위하여 중합효소연쇄반응(polymerase chain reaction; PCR)을 실시해 보았다. 이때 사용한 PCR용 프라이머(primer)는 서열번호 5의 부분서열을 참조하여 제작하였다. 사용한 프라이머의 정보는 표 1에 제시되어 있다.
PCR 반응 | Primer | Sequence |
PCR 1 | F-1 (서열번호 26) | TATCACCCATGTTCCACGCT |
R-1 (서열번호 27) | TGGTATTACTCGTCCGCAGT | |
PCR 2 | F-2 (서열번호 28) | CCAAGTGCCAGTCCTAAACG |
R-2 (서열번호 29) | ATGGGTCGGGTTACTGGTTC | |
PCR 3 | F-3 (서열번호 30) | ACCCAATCTCCTATTCTGTCCA |
R-3 (서열번호 31) | TGACTGATATTGATTCTGGCGA | |
PCR 4 | F-4 (서열번호 32) | GGTTTCAACTCGAGCAAGGG |
R-4 (서열번호 33) | TCGGTTGTATCTTGGGCTGA | |
PCR 5 | F-5 (서열번호 34) | CGGAATTTGTACATCACCGCT |
R-5 (서열번호 35) | CTTGATACGCAGGACCAAGC |
한편, PCR은 실시예 3에서 준비한 박테리오파지 EK88P-1의 유전체를 주형(template)으로 사용하고 (주)인트론바이오테크놀로지사의 Maxime PCR PreMix Kit (i-Taq; Cat. No. 25026)를 사용하여 제품의 사용 설명서에 따라 실시하였다. PCR장치로는 GenePro PCR machine (BIOER)을 사용하였으며, PCR 반응 조건은 94℃로 10분 가온한 다음, 94℃에서 1분 가온, 56℃에서 30초 가온, 72℃에서 1분 30초 가온하는 단계로 구성된 일련의 과정을 총 30회 반복한 후 이를 72℃에서 4분 추가 가온한 다음 4℃에서 최종적으로 방치하는 조건으로 하였다. 이를 통해 얻어진 PCR 산물은 1.5% agarose gel 상에 통상적인 방법으로 전기영동을 수행한 후 gel을 Molecular ImagerGelDocTM XR+ (BIO-RAD)을 통해 최종 확인하였다.
PCR 결과는 도 3에 제시된 바와 같이 “PCR 1"에서는 이론치인 834 bp와 유사한 크기의 증폭 산물이 확인되었으며, “PCR 2"에서는 이론치인 885 bp와 유사한 크기의 증폭 산물이 확인되었으며, “PCR 3"에서는 이론치인 893 bp와 유사한 크기의 증폭 산물이 확인되었으며, “PCR 4"에서는 이론치인 645 bp와 유사한 크기의 증폭 산물이 확인되었으며, “PCR 5"에서는 이론치인 562 bp와 유사한 크기의 증폭 산물이 확인되었다. 이렇게 표 1에 제시된 PCR 프라이머를 사용했을 때, 특징적으로 834 bp, 885 bp, 893 bp, 645 bp 또는 562 bp의 증폭 산물이 발생되는 것은 박테리오파지 EK88P-1의 특징이라 할 수 있다. 이러한 특징은 타 박테리오파지들과 박테리오파지 EK88P-1을 구별 짓는 수단으로 활용될 수 있다.
실시예 5: 박테리오파지 EK88P-1의 대장균에 대한 사멸능 조사
분리된 박테리오파지 EK88P-1의 대장균에 대한 사멸능을 조사하였다. 사멸능 조사에는 실시예 1에서와 같은 방법으로 점적 실험을 통하여 투명환 생성 여부를 조사하였다. 사멸능 조사에 사용되어진 대장균들은 본 발명자들에 분리되어 대장균으로 동정된 것들로 총 10종이었고 형태적으로 K88형, K99형, 987P형, F41형, F18형 각 2주씩이었다. 박테리오파지 EK88P-1은 실험에 대상이 된 모든 대장균들에 대하여 그 형태에 관계없이 사멸능을 발휘하였다. 대장균을 대상으로 한 대표적 실험 결과가 도 4에 제시되어 있다. 한편, 박테리오파지 EK88P-1의 엔테로코쿠스 패칼리스(Enterococcus faecalis), 엔테로코쿠스 패슘(Enterococcus faecium), 스트렙토코쿠스 미티스(Streptococcus mitis), 스트렙토코쿠스 우베리스(Streptococcus uberis) 및 황색포도상구균(Staphylococcus aureus)에 대한 사멸능 조사도 실시하였는데, 결과로 박테리오파지 EK88P-1은 이들 균종들에 대해서는 사멸능을 갖고 있지 않았다.
이상의 결과로 박테리오파지 EK88P-1은 대장균에 대하여 광범위한 항균 활성 범위를 가진다는 것을 확인할 수 있었으며, 이러한 사실로 박테리오파지 EK88P-1은 대장균의 감염 방지 및 처치 목적의 조성물의 유효성분으로 활용 가능함을 확인할 수 있었다.
실시예 6: 박테리오파지 EK88P-1의 대장균의 감염 예방에 대한 실험예
9 ml의 TSB 배지를 담은 하나의 튜브에 1× 109 pfu/ml 수준의 박테리오파지 EK88P-1 액 100 μl를 넣어주고, 다른 하나의 9 ml의 TSB 배지를 담은 튜브에는 동량의 TSB 배지만을 첨가하였다. 그 다음에 각 튜브에 600 nm에서 흡광도가 0.5 정도가 되도록 실시예 1에서 사용했던 대장균과 동일한 종류의 대장균의 배양액을 넣어 주었다. 대장균을 첨가한 후 튜브들을 37℃의 진탕배양장치에 옮겨 배양하면서 대장균의 성장 상태를 관찰하였다. 표 2에 제시된 바와 같이, 박테리오파지 EK88P-1 액을 첨가해 준 튜브에서는 대장균의 성장 억제가 관찰된 반면에 박테리오파지 액을 첨가하지 않은 튜브에서는 대장균의 성장 억제가 관찰되지 않았다.
구분 | OD600 흡광도 값 | ||
배양 0분 | 배양후 30분 | 배양후 60분 | |
박테리오파지 액 미첨가 | 0.5 | 0.8 | 1.4 |
박테리오파지 액 첨가 | 0.5 | 0.4 | 0.2 |
이 결과로부터 본 발명의 박테리오파지 EK88P-1이 대장균의 성장을 저해할 뿐만 아니라 사멸까지 시키는 능력이 있음을 확인할 수 있었고, 이로부터 박테리오파지 EK88P-1이 대장균의 감염을 방지하는 목적의 조성물의 유효성분으로 활용될 수 있다고 결론지을 수 있었다.
실시예 7: 박테리오파지 EK88P-1을 이용한 대장균의 감염 질환 처치예
박테리오파지 EK88P-1의 대장균에 의한 질환이 유발된 돼지에서의 처치 효과를 조사하였다. 생후 25일령의 이유자돈 4마리를 한 그룹으로 하여 총 두 그룹으로 나눈 후 실험사육돈방(1.1m × 1.0m)에서 분리 사육하면서 14일간 실험을 실시하였다. 보온시설 하에 주위환경을 통제하였고 돈방의 온도와 습도는 일정하게 유지시켰으며 돈방 바닥의 청소를 매일 실시하였다. 실험 개시일로부터 7일째 되는 날에 모든 돼지들에게 대장균(K88형) 액을 경구 주입관을 사용하여 경구투여 하였다. 투여한 대장균 액은 다음과 같이 준비한 것이다. 대장균을 TSB 배지를 이용하여 37℃에서 18시간 배양한 후 균체만을 회수하여 이를 생리식염수 (pH 7.2)로 1010 CFU/ml가 되게끔 조정하였다. 대장균 투여 다음날부터 실험군 (박테리오파지 액 투여군)의 돼지들에게는 매일 2회씩 109 PFU의 박테리오파지 EK88P-1을 대장균 액 투여와 같은 방식으로 경구투여하였다. 대조군 (박테리오파지 액의 미 투여군)의 돼지들은 어떠한 처치도 하지 않았다. 사료와 음수는 대조군과 실험군 모두 동일하게 급이하였다. 대장균 투여 후부터 매일 모든 시험동물들을 대상으로 설사 발생 상태를 조사하였다. 설사 발생 상태 조사는 설사지수를 측정 방식으로 실시하였다. 설사지수 측정은 통상 사용되는 Fecal Consistency (FC) score (정상: 0, 연변: 1, 묽은 설사: 2, 심한 설사: 3)를 측정하는 방식으로 실시하였다. 그 결과는 표 3과 같았다.
대장균 투여 후 경과 일 | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
대조군 (박테리오파지 액 미 투여) | 1.0 | 1.5 | 1.5 | 1.25 | 1.0 | 1.0 | 1.0 |
실험군 (박테리오파지 액 투여) | 1.0 | 0.5 | 0.25 | 0.25 | 0 | 0 | 0 |
이 결과로부터 본 발명의 박테리오파지 EK88P-1이 대장균을 원인으로 하는 감염 질환의 처치에도 매우 효과적이라는 것을 확인할 수 있었다.
실시예 8: 사료첨가제 및 사료의 제조
박테리오파지 EK88P-1 액을 이용하여 사료 첨가제 1 g당 1× 109 pfu의 박테리오파지 EK88P-1이 포함되도록 사료첨가제를 제조하였다. 사료첨가제의 제조 방법은 박테리오파지 액에 전체 부피에 대한 중량비로 40% 말토덱스트린 및 10% 트리할로오즈를 첨가한 다음에 동결건조시켜 제조하였다. 최종적으로 고운 가루 형태로 분쇄하였다. 상기 제조 과정 중의 건조 과정에는 감압 건조, 가온 건조, 상온 건조도 대체 가능하다. 대조 실험을 위해, 박테리오파지가 포함되지 않은 사료첨가제도 박테리오파지 액 대신에 박테리오파지 액의 제조 시에 사용한 완충액(buffer; 10 mM Tris-HCl, 10 mM MgSO4, 0.1% Gelatin, pH 8.0)을 사용하는 방식으로 제조하였다.
이렇게 제조된 2종의 사료첨가제 각각을 중량비로 1,000배의 양돈용 사료와 혼합하여 최종 2종의 사료를 제조하였다.
실시예 9: 음수첨가제 및 소독제의 제조
음수첨가제나 소독제는 그 활용에서만 차이가 나고 제형은 동일하므로 같은 방식으로 제조하였다. 박테리오파지 EK88P-1을 이용하여 음수첨가제 (또는 소독제) 1 ml당 1× 109 pfu의 박테리오파지 EK88P-1이 포함되도록 음수첨가제 (또는 소독제)를 제조하였다. 음수첨가제 (또는 소독제)의 제조 방법은 박테리오파지 액 제조 시에 사용하는 완충액 1 ml당 1× 109 pfu의 박테리오파지 EK88P-1이 포함되도록 상기 박테리오파지 EK88P-1 액을 첨가하여 잘 혼합해 주는 방식으로 제조하였다. 대조 실험을 위해, 박테리오파지가 포함되지 않은 음수첨가제 (또는 소독제)로는 박테리오파지 액의 제조 시에 사용한 완충액 자체를 그대로 사용하였다.
이렇게 제조된 2종의 음수첨가제 (또는 소독제)는 부피비로 1,000배의 물로 희석하여 최종적인 음수 또는 소독제로 사용하였다.
실시예 10: 돼지 사육에서의 사양 효과 확인
실시예 8 및 실시예 9에서 제조한 사료, 음수 및 소독제를 이용하여 돼지 사육 시의 사양 결과 개선 여부에 대하여 조사해 보았다. 특히 본 조사는 폐사율 관점에서 실시되었다. 총 30 마리의 자돈을 10 마리씩 한 그룹으로 총 3개 그룹(사료로 급이한 그룹-A; 음수로 공급한 그룹-B; 소독 처리한 그룹-C)으로 나누어 4주간 시험을 실시하였다. 각 그룹은 다시 5마리로 구성되는 소그룹으로 나누어지며 각 소그룹은 박테리오파지 EK88P-1이 적용된 소그룹 (소그룹-①) 및 박테리오파지가 적용되지 않은 소그룹 (소그룹-②)으로 나누었다. 본 시험에 대상이 된 자돈은 20일령의 이유 자돈이었으며, 각 시험 소그룹의 자돈은 일정 간격을 두고 위치한 격리된 각각의 분방에서 사육되었다. 각 소그룹은 다음의 표 4와 같이 구분되고 지칭되었다.
적용 | 소그룹 구분 및 표시 | |
박테리오파지 EK88P-1 적용 | 박테리오파지가 적용되지 않음 | |
사료로 급이한 그룹 | A- | A- |
음수로 공급한 그룹 | B- | B- |
소독 처리한 그룹 | C- | C- |
사료 급이의 경우에는 실시예 8에서 제조한 사료를 표 4의 구분에 따라 통상적인 사료 급이 방식을 따라 급이하였으며, 음수 급이의 경우에는 실시예 9에서 제조한 음수를 표 4의 구분에 따라 통상적인 음수 급이 방식에 따라 급이하였으며, 소독 처리의 경우에는 일주일에 3회씩 기존 소독과 번갈아 가면서 실시하였다. 본 발명의 소독제를 분무하는 날은 통상의 소독제를 이용한 소독은 실시하지 않았다. 시험 결과가 표 5에 제시되어 있다.
그룹 | 폐사율(%) |
A- | 0 |
A- | 20 |
B- | 0 |
B- | 40 |
C- | 0 |
C- | 40 |
이상의 결과로 본 발명에 따라 제조된 사료 및 음수의 급이와 본 발명에 따른 소독 처리가 동물 사육에서의 폐사율 감소에 효과가 있음을 확인할 수 있었다. 이로부터 본 발명의 조성물의 적용이 동물의 사양 결과 개선에 효과적이라는 결론을 내릴 수 있었다.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.
<110> iNtRON Biotechnology, Co. Ltd.
<120> Method for prevention and treatment of Escherichia coli infection
using a bacteriophage with broad antibacterial spectrum against
Escherichia coli
<130> KP090343
<160> 35
<170> KopatentIn 2.0
<210> 1
<211> 29227
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 1
gcaaaaattg cagcaaagat aaattttttc atgataatct cctcagtagt ttatgtttat 60
agtatctcaa ttttcaacaa aagtaaacac tagtagaagc aaacagacaa attacaataa 120
ttggtgattt cagtttcatt cttctcctcc atgttgatga acatattctt tttcaagtct 180
agagcacaag ttttcatatt caactaataa aaatgaatca agtgcgttat ttctatgctg 240
acaccgttct tgtaaagaat ccatctctga acgttgttct tgtgttaata attgataacc 300
tgatacttta gacattttat tctccattta ctcgtttgtt ttgataggtc tataataaca 360
tgtttaaaac aaaagtaaac tattttattt cctcaagttc gttaatcaat aaaagttctc 420
tgacgctaaa aacaaagaaa aatgtgttcc catcaaccag aacatgaccg ctaatagaac 480
accctctgcg gaatttagaa acttcacaat ctagaactgt aaagggtttt aatcctatga 540
ctttagctgt gcgtctattc agttcacaac cactcgcgaa tttttccaaa tcttcttctg 600
atttaaactg atattctcta ttaactagca tcattttctt ttctccgcga ttagctgata 660
gaattactat aacacaactc tatcagcttg taaactacta ttttaaaact tctgtataat 720
cacatgttac aaactgtttc tctaacttga cgattttacg aaagtatctt ttgcattgac 780
gaatctgtcg cttcgtaggg cgcacagcaa acttaataaa ttccactcga ccaaatggag 840
ggctttcttc tgccggaata tctaatacta attcccacgt atctgcaata agtgctttga 900
attgagtatt tttcctgacg ttatatggag taggtttaaa taaaacaata tgcatattat 960
cctcggcaat ccacttcgca tactttcttg tcatcaatga aagctttaac tagcgcttta 1020
ttaacttcag catattgatt agtagcccat tgaacgtcat ctttcatcat tgtggtttct 1080
ttagtaaaca tgctttcatt cttaaaccac cccataaaaa ctacctttac caattccata 1140
acaatctccc catttaacca acaagactac tataccatag tctcgtcagc ttgtaaacta 1200
aaattttaat tcatttgcca aagcatctaa ctgagctcga gtcgattcgt ttctttgata 1260
gcgattctgc tcagcctgaa tctgctgtga acctgctact tcgttcactt cagttggagt 1320
agaatcttgt tcaatttcta cccatttctg atttcctttt tgaacaccca tcaaaaactt 1380
attccattta ttcttatcac catatcgtga tttgatttgc ttaatgagtt gttgttcagc 1440
agctgctaac tcctcggttt caatgaccgc aagcataaaa tcagctgtcg ctggaagacc 1500
agcagattct gcgatatcac tcatgttaac atcggaagag tcccaagctt gtttaccaac 1560
ctgtgctgca gtccaaagaa cagtttcagt ttcaacagcc agagcacgca attcttctgc 1620
gatggcttta acagttgtgt aactattttc tgaataaact ctaatgcggc aagatttaca 1680
aatacctaga tagtcaacaa taatgattgt tggaacaaaa ttcttcttga gctttaattc 1740
atttaaaagt gatcgaaatg tattagcgtc tgctccacca gtaggatatt gcttaacgat 1800
taaacgacca agggtagatt tctcacgcca tttttccatt tttcctttat attcagcgta 1860
agaaatatgt ccatcatcaa tatcgtcaag agaaacatcg agcatgttag catcaatacg 1920
tttagcacag acttcttctg ccatttccat ggagatataa agaacgttat gaccaagctg 1980
caaataatct gctgctaatg aacaaagtcc taatgattta ccaacgttaa cgccagccat 2040
taaaacgttc agtgttccag tctcagctcc gcctttagta attttgttta gaattctgag 2100
tttaaatgga accttacgag ctttattcat ataagatagc caacgtgctt cgtagtcatc 2160
catccaatca tgaccaacgt agctatcaaa tgaaattgat aatgcttgcc gcatgatgtc 2220
aggaatagca ccaacatccg gcattttctt atttcgtttt tccggaggaa gctcagcatt 2280
agtttgaatt tcaattattt tagacgtagc attaaacatc gccctttgct gaacatattt 2340
ttctgtttct tttactaacc agctgtggtc ttctggagaa tcggctagtt ttgaaataag 2400
tgtttttaca ccagaatatt ctgtttcagt aaatgaacta ttttctaatg caacatttaa 2460
cgcattaata gatggaacgc tatgatactc attaacatga gatttaatta atttgaatgt 2520
atttttagct ggaccacttt caaaatattc tgaatccata tatggccaaa cttttgaaaa 2580
ataagcttga tcaaatatga gatgagaaag aataatttct accacactta ctccttaaaa 2640
gaatttaaat tttttctttg accttttatt aaatgcatct tgtagttgca ttgtaataca 2700
tttttctaca tgaggagcta actcagcttt tctttcttgg tcaagaacag caaagtccat 2760
tacaaccttt ccatcaaccc aatctaattt tgtcacatac acaatgtgtg tagaaccatc 2820
ttctagttta atgacaatct cctggataac attttccatg gcagatttaa ttatcttaag 2880
agactcgtta aaaagacgtt cttttctttc ttcttccccc tccgaagagg gggattcatc 2940
gataatttct agatctaagt ctaaatcatc tttattcatt aaattcttcc atatcactta 3000
actgttcgag gtcagtttct aaatcagcag ctgatttact tttactttct ggagatttaa 3060
atttttcaac ctttgagtta atcaattcat caacttcagc ttcaataatt tcattactat 3120
caatagcacc taactgataa gcacgtttaa tagcatctcg gaatggttga tgcttaaata 3180
aaggacccca gaatgtagtg cagttagtat cttttgcacg ccaagatttt tcttcgcgaa 3240
tcatctcgcc ggtttcttca tcaagaaatt cacgagcata ccagccattt ttaggtttta 3300
ccacgaatcc taattctaga gccatatcta acaatccaga ataaggatcg ataccaccgt 3360
caaatttaac atcaataaaa aatttacttt tttctttaac ggtacgagat ttttctacat 3420
ttagaacaaa ttgataccct tgaagatcag aaccatcttt aatctgacgt ttaccgataa 3480
tgaatacagt atcagccgaa tacattacgc ctgtattgtg tgtaacgata ccattttcta 3540
aaacataatg ctctacgtca gcaacagaca aatcatagac ttctttttta ccaacagatt 3600
taacagattt aattttcata ctttaccttg tgtttcgtag tagctagttt caatatacat 3660
atttcatgaa agcataatct tgattgtcgc gttcattcca aattctttta ccatatcttc 3720
gaatgtagtg cgaacccgta aagaactcgc attggaatgc cttaaccacg tgcatctact 3780
gcataagccc atccttttgt gttagcttta attttgttga taattgtgtt aggattaatt 3840
cccagcgctc ttgcagcagg tctgacgccc cggtattcaa taccgtttat gataacgcct 3900
ttttgtctag gatgagaatg ctttaatctt ttctttgctt tttctgatat ttcattaatt 3960
gtttctttgg tgtgtttctt accatagaac ccattgtttt ctccggtaat accttctgat 4020
atgtgcttac ggtgttcatc agaagatttc acgccttttg tgacgccaac atacacacca 4080
gatttaacaa gcggatggtt tctttcaaga cgaatacatt tacctgttat atgatgcttg 4140
tatgatgcaa aatcagcatt agcatatgaa ttatgtccac aagcataatc caaattaaaa 4200
taatctggat ttgttttaac gtttacttgt ttctgataga aattttcgcg ctctagcagt 4260
ttagcatgtt taatatcatc atattgctcc agtatttcaa cagtaacatt attgataaaa 4320
tcatgatatc cgggatatct cgatgagcca tagtactcgc gaccacgggc gtcaataatc 4380
ttaccgtcta cataagaagc atttgtcttg cttcctatgt agtaatacgg cggagtgccg 4440
tttttaattc tatcgttgaa cacaatttta tagacaaaat tcatatgggt acctcaaaaa 4500
tatacattag tccggtaccc atatttatta ccttacaaca caatccattc cagctactaa 4560
atctttagct tcaacccaag ttggaatgtc tttaaccatt accaggaact tgtgggtatc 4620
tgaagtagtt actttataac cgtcttcgaa ttcaatttcg aaacattcag gagtaccttc 4680
agccagagtt tctgggtccc aaacataagt tacttcatta tcaccgacca tggttttaac 4740
acgttcacct ggacgaatat cttcaactgc tttagtagaa ccatcggaca tctggatttt 4800
agtaccagca ataacacaac cacctgtcat cacggtttta ctaaacattt caattgtttc 4860
aattgtatgg ttaaccgcaa cacatggaat atttttaatg ctaaaataag gagtaacaat 4920
acggaataat gacttcagtg atttagcacg agtcatatct gccacagatt tttcattcaa 4980
ggcatcttcc gtttctttct tagaagccat attaccaatt gagtcgatga atacaataac 5040
cttttcacca cgctcaatag cttcaagctg gttcaccata tcaattttca gttgttcaac 5100
tgactgaatc ggcgtatgaa ttactcgttc cgggtcaact cccatggatc gcaaataagc 5160
tggagtaata ccaaattcgc tatcatagaa tagacaaacc gcgtcaggat atttgttcaa 5220
atacgctgca accatagtca aagacatatt tgatttaaag tgtttagaag gccctgcgaa 5280
aatagttaaa ccagactgca taccgccatc aatcgcacca gaaatagcaa tattaagcat 5340
tgggattttt gtacgaatta catccttttc attaaagaat ttagatgtag tcagttcagc 5400
agtcatttta gaagtggaag ctttaatcaa acgggatttt aaatctgcaa tagacattca 5460
ttttttccat aggcatcatt atattttcct cactggttaa agatagagta attataacac 5520
aataaattta ggcattaatc aactgctatt ggatgaatag cattaaactt atgaaatgct 5580
tctgattttt ctttacgcga aacacacatg cgaagaacct ttaatggctc gtcttcttca 5640
cccaacgatt ttcgtttttc aatattcgat gttttccaac gagcttgctc tggaaactct 5700
ctattgattt gttcaagcgc tctattatgt ttagaattac tacgaattga actacaccca 5760
ccgggagcct gtgattttcc agatacaact agatatttga acaaggccaa atgtggataa 5820
ccttgattaa ttaaattgag aaatgcatac atatcttcgc ataaatcaat ttttccatac 5880
ccaatttgtt ctgtcgtaag ttttccgagg tcataccatg tattcgtgaa tccatatgag 5940
ttttcacgat aattacccca agatgaagta attttaaaaa ttggtagacg agcatgacca 6000
tgataatacc cgcaatccat ggcatcttca acgtattgaa tcaattcata gaactgttca 6060
cgagttaatt gattaatttt atctacacgg cgtttatcgt ctctctttcg tattgaactc 6120
atacgaatag tagtatcatc atcaatcatc cagattcgtt gacctgcata catatcagta 6180
attgctttac gagtaccggc aattccgttt acatcatcag gaatagttac aattttagct 6240
ctagacccat aagcatcata ataagctttt tcttcgtgtt cacgcactac aatatggggt 6300
tcataatcag tcggaaacat atcaagggca gaaactgccc ctacacgttg atagcttgga 6360
attacgaatt gaatcattta agtgccttac atttgtcaaa atggtatctt gtcatatttg 6420
gcccacgtcc ttttagtccg caatgcggac atattttttc tatcaaatta tgaggttttc 6480
ctttacgatt tttagacatc gtttctttaa ttattttagc tttttctgcg ccaaaaattt 6540
cttcataagt tttaccagaa ttttcctttg ctcgatttat aattccatat gcctgctcat 6600
ttttaccata cattggatta ccttcgcctt tcattctttt agaatgatca ggacgcttga 6660
ttccacgaaa ggcatttccg cacttatatc tttcttctgg agatagtttt ttaccgtaca 6720
ttccatttaa tttgcctgga aaacttcctc cccatgcttc attctttaaa ttatatgaat 6780
ccggacaatt agcagcatct aaacaagtta aaataatttc ttcaacctgt ctaaacattg 6840
gtccttcata taatatttct ttattaaagg attttattcc atatttcttt ttagcatgtt 6900
gccaaactac acccgaacca tcataattcg ggttgtgacc atcatgactt cctatatacc 6960
actttttagt tttaggatgt ttatacttat aaacatgtgg cacatttact tccattttcc 7020
agtataatcc tttttagcaa tatgagtttc accggtgttc caccaatggt caactaaata 7080
aaactgattt tcgtacacat gaagacttcc aacgttccat ataatagaac ctgctttata 7140
ttgccgcgat gggtcgcctg cattcaaatc agatactaat ttatctagta cgtatttttg 7200
ccaagcataa tcattacgat agcctgccca gcaatcattg cttctcatgc taacaaccgc 7260
attgattttc ttgtcacgaa ttaagtattg tactgtattc gtacacatga aatctgacat 7320
accatcttta ttatagtcaa attgcataga tggacgagta taaatcatga taccacgtcg 7380
agaatcagga ttttgaccaa gttcagctaa acacatatca tactgggcat agttatcttc 7440
tgaccagata gcccaaccat aattcgagtt aatttcacct ttagaagatg ctacttgttg 7500
ccaaatcttc ggtgtttcac ccggaatatc tttaacgaac aagctcttag atttatacca 7560
ttcaagttca cgctgaatgt attcatcatt aagagcgcca aaaataaacg gttcatctgc 7620
tacaaatgat gcgccaataa tttcaatagt tttaacgcca gttttatcaa ctacgaaatc 7680
tttttccttt aatgcaagcc ccaaatgaag acggatttct tcaactgtca tagagtcact 7740
aatcatttaa acctcaattg atacattcat atttaacttg taacagtaat aaactccaac 7800
ctaaaacaat agttggaatc ataagaggaa ccgttacact atagtatata cttattataa 7860
ccatcaagat taaaagcaat gctgctataa ttttgctttt cattccttct ctctgatgat 7920
aattacctga tttggctgcg cagacttttt agtttcacct gcaattgacc aaataaatgt 7980
aataaaccaa ccaataattg accagttaaa cagtaaagat gtgaaaaaga ttcctactgt 8040
tgattttgac ccacgcatca aagcaataaa ccatggaagc gtgtatataa taatagccaa 8100
cacacccgaa actaaaacca taaaaattga acctgctact aaagtttcca tgttttcctc 8160
acttagtcaa attttttaca catgaattat aagaattcac tacatactcc atcggagcat 8220
ttttacctgt gcgccattgg taattattag cccaatttgc ccaaagttca gcgcagtaat 8280
tttcaatttt ttcttcgcgt gtaattacat ccgaattacg atatgcttga gcggattcat 8340
ctggacgaat agcctcgtca aaattcgcct gcatttgttc tactgtctgt tttggagctt 8400
ctttataaca cttgacatta ggattataaa atttgcttga acagtttaca atttttcctg 8460
catcagactg atttactacc ggtccttgag ctacacaacc agtaagacct aatgcaataa 8520
ccaaaatagc gattttcatt tcattctcca aatccgtatc agttgatagt tgtatagtac 8580
catggaagaa cagggatgta aactgttttg tgaaaaaatt tttagggaat tcaaagggtc 8640
cagaatcatc tgtttttcat aagtatagat ttatattact tgtatgaaaa agggacccgg 8700
aggtccctag atttattcta tcagccaaac aggaagtcta acgaagcttt ttcttcatag 8760
tccataccag ccgattcaca catacccgca agcggtttaa caaacgattt ttggaacaaa 8820
gttgagtagt caatccaaga tagtacatca gaacgaattt cttttggaag ttctgtaccc 8880
gatggccaag caatgcactt gtcaccaaat ggatttcctt cacgtaatgg aagaaccatt 8940
actttatttc catccaaaat tggagctaca cccagaccac taacagctcg acgataagtt 9000
agcacaccgc gaatatggaa cgggcattta aatcctggcc aacctttatc atcatatttc 9060
gctatatcgt tcgcagtttt tacttcagca ataactttat agtcaagttg acgatattct 9120
ttctcgaagt tcttgtagta ttcttggaca gactcttcac cttcttgaag aatacgacga 9180
atactttctt cgagagcttc ttgcactgct tttggtgttg aactctgctg agtttccata 9240
cccatgattt ttagatgcgg ttcagcaaat cgtttatctt ccatatcata aacgttcaga 9300
gcataacgct ttttcgcttt ccaaaatcca ccaacgccct ttgaaccaag tggagggcaa 9360
gaaatagctt cacggtccat atgcatcaga tgctcgcggt tattcatata atcacataac 9420
tcacgatatg caacatcaat cataggttcc atctttttct taccgaactg attcatgaat 9480
tcaactaaat cattttgttc tttaaagcgg tcaagaccta ctttttcaat aactttatct 9540
acacagacat ataccgaatc agtatcacct gctgcgatga aatcttcacc atcagttcca 9600
cacaccttat tcaggtattc attaatttta cgagcaatcc actgaatacc gacttgacca 9660
aaaattgtga tagcagtagc atttcgcaaa tcatagtaac ggaaatgaat attaccaaga 9720
gcaccataaa gactgttgat aagaatttta cggttcagct gatttgtgtt agcaagtgta 9780
gcagcttttt cacattcttc aatcaaacta ttaagaacag attcagtgta attcgataat 9840
tcgtttaaga aatcatcact gaacttaaca tatcgttcaa cttctggttt agttgagcaa 9900
gaccctgcac ctttcataat aatcttttta atagcttcgg cattcatttc ttcagcgaac 9960
attttctttt tccaatcttt acgctggaaa aatactttag cgatttcctt tggaatgata 10020
ccttcttggt gcttatcata catccatcca ttcggagagc aagaatattc atcacttggc 10080
ttaggagctg ttcctgcgat atattcatga attggatgaa ctttaaactg cccacgaata 10140
gtctcaggac taatgttaac ctgacgaata atgctaggat acagagacgt caagtcaaaa 10200
ctcataatgt atcgacgagc aatcggttta ggttcaaaca caaatgcgcc tggaaaactc 10260
tgtttaacgt gcgaaccttg ttgaggaata accttatgtt cacctttcag cgagttaaaa 10320
ataatagcat cccaagtttt aataggactc attacaccag aaaaaggcat tttagcgtaa 10380
taagacatac ttaaaactag atcgataaac ccacgaattt tatcaattgc ttgaactgat 10440
tctacgtcaa tgatgttata actaatgtat cgttgatgat tagtctcacg aagtttatta 10500
ataggaccat cgtacggcaa tttacctttt ttggtttcat gttgagcaac tgattccaaa 10560
gagaacgatg gcaaattagt aaatgcgaac ttcttgtata aatctaaata atcaagaata 10620
gatacgccat caatagaata aatttctttg ctaccgtaca tattttgaat tagtttagat 10680
tttactcgac cgattggaga gaagcgtttc atactgcgtt caccgagaac cattttaaca 10740
cgattcatga tatacggaac gtcaaatccc tcaatattcc aaccggtaaa aatagcaggt 10800
cgtttctgtt cccagagatt aatatattcc atgagcatat cacgctcatt atcaaatggc 10860
atataaatta ctcggtcaag aatttcttga ggaacttcat caccaccttc acagtcaagc 10920
ttagcagcta actttgcatc ccattttgat actgaaccgt acattgaatt caacaaatca 10980
aagacgtaaa aacgatcgtc aattgaatca taatgagtga tagcatcaat ttcatattct 11040
gctttcattg ggtcaggaaa tttatcacca gtaacctcaa tgtcgcagtt agctacacga 11100
acaaattttc ggtcataaac aatttctgaa ccatatgtat cactgatata agcgagttta 11160
aaatcgttca taccgagagc ttcgagaccg atgtcttcca ttcgtttcat ccaatctcgt 11220
gcatctttca ttgatggaaa tttttgagga gcacaatttt taccataaat gtctttgtat 11280
tttgactctt ccttacagtg cctaaacata gtcggaagat attctacttc acgagtacgt 11340
tcctttccat tttcatcaat ataacgttca acaatgttat ttccgactgt ttcaatagag 11400
atataaaatt ctttcataga tattccttag tttatagccc gagttattag gctcttgata 11460
tattatactc caaataaggg gccgaagccc cttgcttaat taccaatcgt atatttagga 11520
acgagtttcc attcatgttt ttgtttaaaa gaaataactc ggaagttatt agttaaatct 11580
ttcataaaag ttctttgacc gggaacgatt tcaatcagtc cccaatcttc taacagccat 11640
gcaatcgaat cacgacgaac ttcatcttct tctgtcattt caacttgacg gccatccata 11700
cgaagcattt ctttaaaatg aacgatatag tatagtcctt ttttctgaag aatatgacag 11760
gactgataca gaactttatc tttattatta gcaattccca tacgagtcaa agtttctttt 11820
actttcagaa aatcttcagg ttttttaaga gtaatttcaa tcattttacc attccaatgc 11880
tagttttttg agttgtttct gttcttttac gttcttagtc acttctttca aaaaatcatc 11940
cgtgactaat cctttaagtt cttttaatac taaaggtagt tttccatttt tagtaagaat 12000
tgatttatag ttaattgcat catttgtgtt aacttgatac cgcttagcaa gtaacttaat 12060
aatcaatact tcggtggaat cttcaactag ttttgcccat ttaccatatc ttttaccacg 12120
aggaacagca gccatcagat aattaaaatg ggcttcatcg cttaagcctg atccaattaa 12180
attcatagca tatacagctg gcatgcactc tggaaattgt gataatgcat tttcaaccat 12240
gaattttgaa taatcttttt gagcaataga gcatttagtt ttattattaa tagctccaat 12300
tatttcaaaa aattcatttt cagctttttc tttaaaagaa tcagcagcgg attggacagc 12360
tgtccaatct tttgaatacc aagcaacttg atgctcgttt aattgaatat catcttcaaa 12420
taagctcata tcacttccac tgcatttcgc atgctaattg aatgaaaaga taagctaaat 12480
gtaattcagt attagctgca ataccatgat actgattatt ttcgccgaca atttcgtaca 12540
tacgaataat actctgtgga gttacacgtg aatagatttc ttcggcaagt ttacctacga 12600
accacgaata atcagctgca tattttggtg ctaaagctct gagctgttta acatctttat 12660
ttttgagaga ttcaagaaca tcatcaatag caccacgatc gttagtaacc agtgataaaa 12720
taccagcatc caaaacacct ttagatgaat aactatcgag ctcgccaata gttttacgaa 12780
aatcaggaaa attcttttta accaaagctg ctacaacttt catatcagct atagcaattc 12840
cttcatgctt acagatttca gtcaatcgac gaatcatctg cttcatcatt tcaattttat 12900
cttcatcagt cggttgaccg aatgtaataa ctcggcagcg cgactgaagc ggtttaataa 12960
taccatcaat attgttagca gtaataataa tgctgcagtt tgaactataa gcttccataa 13020
aggaacgaag atgtcgctga gactctgcta accctgaacg gtcaaattca tcaataacga 13080
ttactttttg acgaccatca aatgaagctg cactagcaaa attagtcaaa ggaccacgaa 13140
cgaaatcaat tttacagtct gatccattca caaacatcat atcagcattt acatcatggc 13200
acaatgcttt tgctacagtt gttttacctg ttcctgaaga aggagaatga agaataatat 13260
gtggaatctt acctttactt gtaatagatt taaaggtttc tttatcaaag gcgggaagaa 13320
tacattcatc gatagtagat ggacgatatt tctgttcaag aatgtgttct ttttcattta 13380
cagtaatcat aatttcctca ttcaagtttt agtgtaaatt ataaagggcc gaagcccttt 13440
attaaaagtc gtgggtagaa tcagcttcaa gagctactac ataattcgca tgttcacctt 13500
caaatttagc agcgccttgt ttaccttttg cccagagcag aagtttataa tttcctggtt 13560
gcattttcat atttgccata ttgataatga aattaaatgt attttcacca tcataatcac 13620
caagagtcaa agaatattta acacgggtca aagcagaatc ttctacttta ttaaaaccgt 13680
taattacgat tttaccttct tttactgtga tagcaattgt atcaatctgc agaccgcgag 13740
atacacgcaa tagctgttga aggtcttcag ctttaatttc ggtaacaaca gatgctaccg 13800
ggaatggaat cggtttatta ggagcaacta ctgtactcgg atcggctgct ggccaaaaaa 13860
ttgttgagcg agcatcagca attttaatat taccatcttc tgactgggaa atttctgcat 13920
catcattaac taaagacaga ataccgagaa aaccgttcaa atcgtaaatt gctacatcaa 13980
aatcaataac gtcagaaata tttgcttccg cataagttgt accattaact gcgcgagtca 14040
taataaattg accggattta agcataatac cggagttaat agtagcgaaa tttttcaaaa 14100
tattcagtgt atctttagac agtttcatgt aatttccttc aattcaaatg agatttaatt 14160
ttataactaa tttaataaag caattaacga ttaaaatcgg cagcaattgt ttccgcaaca 14220
agttgagcag caacaattag acgttcatct gcattaccac aataatcgtc ttcaaggcgt 14280
tcaccacatg aagtcataat aaatttagca ccagcattta gagattctgt agtatgtttg 14340
cgcattagtt caatccattt attacttact tcacgatcga tagcttcata atacgcatga 14400
cgagcaggtg cagatttaat tttattctga ataacttcca tcgcgttatc agaaagagac 14460
aaaacccatg ctcgacgaat tttattttgg ttttgtggat ttgattcaga acgcacgtgt 14520
tttggctgaa tatcttttac atcaacagta taattcacag taattttagt cataatacgc 14580
ctttagtcat aataatcagt aacagtccaa gcttcatttc tattggacat tatttttgta 14640
tattctgatt taaatgcatt cctaagcata gattcagtaa ctatatgctc ttcattagaa 14700
aaattatttc tcagaatata tcgttttatt tcaggaatag ttaatagatg ctgtccagtt 14760
gaatattcca tgtttttcct ccatagagat tatactctaa taaattaaag cataatctct 14820
tataaattaa accattacag taaatcgacc aactttcttc atttgaagat gctgaccata 14880
tgcttgtggg tcgtggtctc tatgtgaaat aacaaaaaca ttagtatttt ttaaactatc 14940
taaaatagtt gaaatagctt ttacaccttc aacatcagtt gctgaatcaa aaacttcgtc 15000
aagaattaac gtgtttattt taacacctga aactttttca gcaatatcac gccaagtaaa 15060
taaaagagca atatcaattc gtgctttttc gccttgactg aatgaagcat aactaaaatc 15120
ttcacgaccg cgggatttaa ttgtctcatt aaattcttca tctaatgtaa acacataatc 15180
agcttccatt attttaagat aatggttaat ctgcttatta aataatggaa tgtacttttt 15240
aatgatagca cctttaatac cagaatcttt gagcatatca gtcaaaattc ctctgtggta 15300
tttttccatt actaaattag tttttgtctt aacaatttta tcaagttctt cttgaagcag 15360
tgctatttca tcagcatggt caataaactc agatgatgct ttttctatag ctgctttaac 15420
ttttttagct ttatctaccg tcgtgattag agattgcttt ttattgcgaa tatcattcgc 15480
caacgtctgc tgggttttaa tattatctcg gtattcatca acgagaactt ttaaattatc 15540
acgatgtgtt gaaagctgtt caaacgaatg cgtgcattca gaaactttat ctttaatttt 15600
agaaacaact ttatcaccgg aacttaattg tgacaaacaa gttggacata atccaccttc 15660
gtgatacata ttaatgactt tattatacga gtcaattttt gatttaatta aaaatgcttc 15720
ttgaccgatt ttattaaatg catcagtcgg gtcttcatcc aaaacaatat taactaatct 15780
ttcattagct tcttctattt ccgattttaa cgttctagct tcttttgcca aatcatcata 15840
catattctgt agacgagtaa ggttatcacc agttaatttt ttctggcgtt caacgttatc 15900
attatatatt ttaatttgtt ggataatact atctttttta acatcaagca cttggttttg 15960
tgaatttaat tcacgtatta gtgctttatt aagcttatcc atttcagcta atgttcctac 16020
ctcgagcagg tcttcgacaa gctttcttct tgcaggagtg gataggccca taaaaggggt 16080
atatccagcc gtgccgagga cgacgatctg tttgaaactg gcatatgaca ttccgataag 16140
ctgttcaaat tctgcttgga aatctttact gctggcagat tcattaagac gtgtaccgtt 16200
aacggtgatt tcgaaaacat ttggtttttg tcctcttttg atatagtact ttttctcatc 16260
atattccatc cacagttcaa ctaaaagttc tttcttattc gtgctgttta ttaattgacc 16320
tttctttacg tcacggaatg gcttgccaaa aagcccaaat gtgatggctt ctaacatagt 16380
agacttacca ccgccatttc gcccggtaat aagagttttt tgaaccttat ctagttgaat 16440
gtcaatagga tttccaccta ctgacattat attttgatac ctaactcggt ttagtttaaa 16500
attcttcaca aaagattcct tttaatgtat cttttagacc attctatcat atcatcataa 16560
tctaaaaagt attcatcaaa ttcagccatg caaacaacgc cttgtgctgc ttttgatgtg 16620
atataaatta ttccaacata tctagaatct tcttcggtgt aatcaatatt tgctatgaat 16680
tcatcattaa tgtcaaatgt cgaaaacttc acagtatgca tccttaatac aagatacagc 16740
catatcttgt aatgatttag gtgtgtcatt atctaaaatg ttgaagttaa aagatacagc 16800
ccagtcagtg cagaccgtaa cctttttaat ataattatct tcaacctcta gcggttcaaa 16860
ccaatattca ataatttctt tatgcccaat atcatctttt acttcgcatt caaaatgctg 16920
actcatcata acatttttaa attcatcaaa agtcattgtg ttgcctctac atataactga 16980
tttgcatatt gaataagtgc ttcgcgatca gaatcagtga tgtctggaat tgcattaatg 17040
tattcttcca tcaacgtctg aagagattga acttccactt cttcgttatc atctgactcg 17100
acagagttat caatctttga cacaactcgt aatgaatgca caactttttc tagttcagat 17160
tcgaacttcg ttagattttt gtctacttca gttactataa cacgtactga tagatttgta 17220
aaatctttat agtcaatttt tcccttaaat ggatattgaa ttcgacgatg ccaggtggtg 17280
ttgtttggaa taaattccat tcgttctgtt tctgtatcaa acatccagaa cccacgaggg 17340
tcattctcgt cacctgcagt tagtgtccat ggtgtcccaa tatatctgac gttagcagcc 17400
tcagagatag tatggaagtg accagaccac acctctttat aagtcttaag gaaatcaggt 17460
tcaagaccgt gagatttcat tcctttataa aaataaaatc cattcagttc ccagtgacca 17520
acacaaaaag aagcagatga agttttaata tgttcaagaa tttcaccagt attttcttca 17580
cacatccaag gaattaaatc aatcaaacat ccgtcaaaat ctactgtagt aggcttatca 17640
tatactttaa cattaggata tttagccaaa agctcagtag aagcatttgg agttaaagta 17700
tttttaaagt gcatatcatg gtttcctaca acagtatgta gggtaatacc agcatcatca 17760
agcatttgaa ctatttcacg agcgaactcc atagttttat gcgtgatcgc ttttcgcaca 17820
tcaaaaatat cgccgtattg aatccataca gtaattccat ttttcttaga atattctatt 17880
gcttgtttaa ttccatccag ctgaatagat tgaacccact catcatcggc tttaacacct 17940
aaatgccaat cacctaaatt taaaattttc atatatcaag aaccgtcatt gaaatgcaaa 18000
ataaaattat tgaaataaat ccatctggag tgctaaagaa cccaatccaa catgctctag 18060
tgaatagata aaacgcgaga aaaagtatca catatccaag aaatatcatt atatcaaact 18120
ccgtataaag ctaaagggcc gaagcccttt attttgtaat aatgtcaaac tgttctttaa 18180
agcagaagct tgaatcttga tgctgataca aaaattcata agctttttcg cgttcacggt 18240
cataaagagc tcggtcagat gacagttctt taatacgctc aaatgttgat tccatgtcat 18300
tttcatcaaa ccaaacgata ccgctatcgt gtgaaattag cggagtatta tcaacacgga 18360
attttaaatt ttcaccagta gatttccaaa atactggaat tgttccgcac gcgccaagct 18420
cgagatgagt atattctaaa gaacgttgta gatatttttt gtccaactta ctcaactgat 18480
aaccaaatcc ggatttactc atgcgttcaa gcatttcgct atttacataa cggtcaagaa 18540
tttgcgttgg caaattagga gcaattttaa tttggtctac ttgatgaaga cgataatact 18600
cgtatggaat tcctttttct ttaataggaa tgaacgcagg agaacgttcc agaccttcca 18660
taatagtact tagcccagca ggtttaagat gtttttcgtg aaaatcaaac atctgataaa 18720
aacctttcca tgtagtcgta cgaccaatcc aacggttgac attcatgtta atttcagaaa 18780
catctttcca gtaggttgat cgaactttcg caatatccat aggaggctga aagttgtata 18840
cggtcggtgc ttcttcaata tcatcaaaca gtgaaacagt ttctggatac cattctttca 18900
tcagaacttt attaaaatcg ccattatcag aatgactaaa aataacatca gctcgacgaa 18960
cagtttcttc taatcccaaa tttcggcgca aagaaagaga agaatggtca tgttgataaa 19020
ctacaacacg aactgaaggt ttaatgttat caataatttt tttatagtta ttaatagtgt 19080
cttcttcgac tgaagtagca ggaactgaat tgataattag aatatcacaa tcatttacca 19140
gcttaagcgt tttatcgtat tcttttgcca ataaaactgg aattgaaaat gacttataat 19200
catgcgcgca attacgagta aatgatttat ctttagcata aaccaaagtt acttcatgac 19260
catttttaat aaaccaatca cgttgctcaa gagaaaattt agttacgcca caaccttcaa 19320
gacctcgagc cataaaaatg catactttca tttaatatcc tcattgtttt ggtttatttt 19380
accaaaaatt tataaagcaa tataggagcc gaagctccta tccgcataat acaccataca 19440
gaggctcatt agagcttcta aattttatac gtttatgtgt tatagttcct tctgctttag 19500
ctttatcatg agactcttta aagcgcctca tcatttctac tttagaggaa cgaattttat 19560
tataatctat ttcacaagtc tgggcgttca tctttcacag ttgccaccat tttttgactt 19620
gataggaatc aacccacact ttcatattag ggtctgctct tacaatagga ggattaactt 19680
ctttaattga actatcgtgg tattcttttt cagaaatttt cacgcaaaga tgaccattca 19740
aagattcagt aaatcctgca ttaattttaa gacgcttgaa ttttacgtgt gtaagcatca 19800
atcatatcct caatctgtga tctagtagtc ttccaaagaa tactaatgag ttcatcgtta 19860
tatggctgtt ttagaatatc ccgacttttc ttgatagcat attcgtattg agcaaaatta 19920
ttgttttcag ctgcaatctg agcgtgctta taaagacggt tcagttcgcg tttattttta 19980
gacaataact tatttgcttt tctttctgct tcaagacggt tcttttcttc aatagaagaa 20040
ataagctttt ccacttcatc attaatttcg ggtttatcag tcatattatt tctctaatat 20100
aaaataaaaa tcatcatctg ttaaatgata ccgatagttt aattctacac cattagattt 20160
aaaagcggta tcatacggat tttctggatc aatatcaatg tcaagagcta aaacttccct 20220
gagatacatt ttaagtaaat agggaatagc ttcaacttca ggtatttctt ccaagaatcc 20280
ggagaggtta atcgttagcc tcatataaaa aatccaaact aggagaatcg tctacaacac 20340
ttttcttttc agcccccggt gttctatagg ttgattcttc gtaatgcgtc attttatcgt 20400
agatgtcttg aataaaagtt tcatctacta acgcaaccat atcgtcgtca cgactgtcat 20460
agacattgtg aacgaagtaa ctgtatttct ttgcaacttc cttacgttct tttttaatac 20520
gttggacgaa tgcattaaaa caagcttgag ttatatatgc atgtgggttt ttatatttcg 20580
tttcatcaaa attgtgaagc cctttaatag aagcttctat accgtctgca atcatttctt 20640
gtttccagga ttgggtgtat cctgaaaagt tgaaacgttt agataagcct tctgcaataa 20700
gcataatggc taatccgata gtatcattct ggcgaactac tttatttggg tctttattat 20760
ttgctaattc tgttttccaa tcaataatag cttgtaaaag ctctttattg tttacgtaat 20820
tatatttagg cttagtttct gacattttca cctcttagct caattcatag atctattata 20880
ttataatatt tgaagatcta tcttaaagca tagaggatat cagttatcta agtaagcagt 20940
atgcttggaa cactttctcc atcatctttt taaattcatg aatatctatg taatgatcat 21000
taatatcagc gcgatataaa aagtctaaaa actttttatg ggtattagaa tatttacttc 21060
cagttaattc agaaacatgg ctttcccaat atccaacacc agttttattt gggaaaaatg 21120
aaattttcat gtattggtca acatagaaaa taccaaaatt ttcaatagca atagaaatat 21180
taattaattt catacattca tcaacttagc cgcttcaaga gctgcatcta gtgaatcaaa 21240
ctggtcaacg tattcaatca attcgccata attggcatat aaccaccatt ggctaaattc 21300
atactcaagg atgaatccat ttccttcaat ttgagttaaa ccaatgccgt ttgtatttac 21360
ttcatatccg gcaagacgca aatcgttaat aagagcttcg ttcataatta tgccttagta 21420
attttcaggt cagcaaattt tttcttgcgt tgatttttca tacgacgaat agttttatcg 21480
gaaatttcat gtttttgata agatttagat tctacaccaa aagctttaac atcaaattct 21540
gacaagatat attgaaccaa caattcacgg acagtattgc gtccaatctt ctgatcattc 21600
tgtttcatca tctgatgaag ctctttttcc catttatcca aaatttgagg agttacaata 21660
tcgccttttt ctagcaaaga aactacttta tcatatgcgt aagaattaat gacgttttta 21720
atttgaatag tcatacatta tcctcaattg cgttaaaatt ttattatcca aaaagggccg 21780
aagcccttag ctaaactgtt tggcgccctt ccagccttcg tacatcattg cggctgatat 21840
taatattgct cctgagcaac ttgaatattt gtgattccaa aaccagttta gaaaaacttc 21900
gtcatcaata ccttgggcta tcatattttc aaagaactga cgacgagctt cagcaattcg 21960
ttgcgataat ttagattcag gattcattta aattttccag ttaccatttt catcaataaa 22020
tttaatccag tcatttactg accacttggt cgtatcgccc tttggagcaa catttaaagt 22080
gtataatcct tgtttaaaaa gcattcgttt gatattcata ttttcctcag ctgtaacgat 22140
agcactcgtt tgatttacgc ttagcaactc gttgagaagt attataatca aaatcatcgt 22200
caatgtaaac tgattttttc aactttctta cttcaccacg taattggcga tttagctcat 22260
ctttaacttc tgaatcaatg cctttcattc tacgccattt atcagagcga aaaatgtttt 22320
cgaccatatc tttatgactt acaccatcag gagctttacg ctttccgaaa tagtcataat 22380
cacgaacttt caagtcttta cgacgatacg ttttacccat ggagtttaat ttccttagca 22440
actgaactaa atacagcacg gtcacaaatc atgtgtttat gtaacttaag tataagataa 22500
taaacttcaa aaccgtttac ataagtaaca cgaacaacat taccattaat aaaataatat 22560
tgtccctttt taatttcttt atcaaccaca accatatcaa atcctcaaag gcaattcatg 22620
tgttaataat accacagttt gaacttcttg taaacaactt tgtgaaaatt attttaggga 22680
atgataagaa gggaacgata gcttagaatg gtaatataca gaatgtgaga aagaaaggcc 22740
cagagggccc gtcttagtct tctatgatat ctctatcata tccaagtgaa atgagagttt 22800
ctttgaagtg tttaatgttc ttttgtctag aatcattaat gaaaatgact ggataacgaa 22860
tgttaagaga tgtaaatcca gcgcgtttag caagagatac aatcagtgga cgatcatact 22920
cgatcttacc attatttgta ataactttat agaaagtaaa aggagcattg agctccttta 22980
gaagttttgt aactgattga catccaggac aacgaccaac ttcatctgga attccataga 23040
cttcaatctt attctttaag ttcgagtttt gttccacgag aaataattcc ttgataagcc 23100
caatatggcg ggttaacaga atcatcgcca gaattttctt caggaaaata aacctggata 23160
acaaatccag attcatcaaa ggtaaaataa accgtaggta attcacctaa caattcagca 23220
cgattattaa tttcttcgag ttctcgttca cgtccggccc aaaaactagg atttagacta 23280
cattcataga aataatagtc attaccgaac atatcaaaac cattccaact ctctaccaca 23340
taccgctcaa aactaatcat aattaagcct ttttatcaag aacagaattc agtttgttag 23400
taattttatc cagacgctca ttgaactcgc tagaagacag tcctttttct ggagaaatta 23460
agctaatcac gaaaaatata gcaataaaag gaataagaaa aatagctcca actgccataa 23520
acaaaaagaa tgttacggtt gtaagaaaat cagctaaacc tttacgaaat ttatacatat 23580
ttacccttaa ttgattaacc aagcattgat aagcactaaa ctatattgcg aataaaattc 23640
tggaccaaaa tgaaaaatca tatcatttat agtgtccata atataattca atttaatcat 23700
gtttccacac cccatcggta tttgaccaaa gtcgctgatt atctgatcct cgccacagct 23760
ttttggtcgg aagatttttc tcatacttcc catcaataat aacatcaaca tatttaagca 23820
tttctagttg tttaatatct tcaaacttat atcctgtcca caaccaaatg cttttattgg 23880
gataaagatt ttttactgtt tgaacaatgc aatgaataac atctcggtta tcaggataga 23940
gagggtctcc tccagttata gttaatcctt ctatataatc attattcaaa cattcaatta 24000
attgttctag tgtttcacca gtgaatggaa caccatttct agcattccat gttgatttat 24060
tataacaccc ttcacattta tgcaaacaac ctgtaacgaa aagaacgacc ctgcatccag 24120
ggccattcac aaaatcacag ggataaaatc tatcataatt cattggtgtt taaccctatg 24180
catgatttct ttatttttgc ctagattaaa tccgcgttca ttcggatttc ccaaataacc 24240
acaagttctt cttattgtgt tcatcttttt aggatcagtt tctccacaaa tagaacaaac 24300
aaatccgttt tcagtaggag tcatttcatg agtgcttcca cacgtaaaac atttatctac 24360
tggcatgtta acaccaaaat aatctaaatg ttgtgcagca taatcccata cagcctcaag 24420
accttttagg ttatttttca tatcaggaag ttcaacataa gaaatgtgac cgcctgttgc 24480
aatgaaatga tatggggctt ctcgagaaat cttttcaaac ggagtgatat tttcttctac 24540
tgaaacgtgg aaactattag tgtaccatcc tttatcagta acatccttta cacttccata 24600
tttctcagta tcaagtttac agaagcgata gcacaggttt tcagcaggag tagaatataa 24660
gctaaaagca aaaccggttc tttcagtcca ctgcttaaga cgagcattca ttttagtcaa 24720
aatttcctgt ccaatatcac gaccgacaag aatattcaat tcgtgaatac caatgtatcc 24780
tagggacact gaacttctac cgtttttaaa taactcaatt atgtcatcat caggtttaag 24840
acgaaccccg aatgcacctt cttggtaaag aataggagca acagtcgctt taactccttt 24900
taaggaacta attctacaca tcaaagcttc aaaacataaa tccattcgct cattgaataa 24960
ttcagtaaat ttctgttcat tgaattgtgt tccaatataa gaatctaacg caatgcgagg 25020
aagattcagt gttacaacgc caagattatt acgtccatca agaatttcat taccagtcga 25080
atctttccat acactcaaga aactacgaca acccatcgga gaaacaggaa tagatgaacc 25140
agtgatagct ttattgttct tagctgaaat aatatcagga tacattcttt tgcttgcgca 25200
ctctagagca agctgcttaa tatcatagtt cggatcgtct ttataaagat taacaccttc 25260
ttcaacgaac ataacaagct tagggaaaat aggagttatc ccatcacgac caagaccttt 25320
aatacgattt ttcagaattg ctttctgaat cattcgttca gtccagtcag ttcccgtacc 25380
aaatgtaatt gttacaaaag gagtttgtcc gtttgaactg aaaagtgtat ttacttcatc 25440
attatattca gcatgagtcg caaattcatg cccgtttata tgaaacaaca aaatttggat 25500
agtccataga tatgcaacgt tcttttatag tgctaggatg aaaatttagc gctttagctg 25560
cttctatata agacgtatac ttaataccgt caacaaccac atattcagga actttatgaa 25620
tagtagtctt aatactcaaa acaagaggat gagtttcgac ttcactttca gtgcaattta 25680
aatattccgc tgctttttta aaacttctaa aagttttatt tttaagcttt atcgatactt 25740
gttttttact ttttcgacta ttgatattat tttgcacatg ttccttagat cttccgtttt 25800
tagcataata ttcagctaca gaagatttta tattgttttt atgatattcg gataacactt 25860
tacccttatg agcatctctt aatttttgaa tatgttcttc agtatccgga tgcttataaa 25920
actttttacc gcctatggat ttatttaaac attttttgct ataaaaatat ttacgtatga 25980
cctcttcttc atgttttaat gcatctttat aactatcaaa tgtttttaaa attatccatt 26040
tagtaggtgt atcagttttt aagcgttcat ttatatactt agatgacgtt gtgtaagttt 26100
tccagtttgt gggcttgttt ttaattgttc taaatttttt ataaccgata taaatgtcgc 26160
cattagaaaa cttaactaag tatgtaaatg cgtctttatc ttttatttta gtacaacgtc 26220
tttttatcca tttcattgtt tcacctcgta ttcataagat aatcttattt atacaagatg 26280
actgctgcat gtcgccatgc agattagact atatcttcat ctttcgatgc cggccgtttc 26340
gaatagcatt agcttctatt ctacaccgct acattcatca cggttagtcg ttaggcattt 26400
agttcaaaag aacatttagc acgggattgt ctactagaga ggttccccgt ttagaccggt 26460
tttacatgag cctgaattaa attaactcat acgcttggaa tgcatcgtat acatcttttt 26520
ctgttttgga ttgagcataa ttcaacgcat cagcgatttg ccatttttct gcatcctcaa 26580
tatgttttgc ataggtgcgt ttaacataag gagaaagtac tttatctaca ttcgcaaaag 26640
tcgttccgcc atattggtgg gaagcaacct gtgcagtaat ttgcgccata attgcagtag 26700
caacaccgat tgatttagga gtttcaatct gtgcattacc gagcttaaat ccgttctcaa 26760
gcattccttt taaatctact aaacaacaat tagtaaaagg caatgatata ctgtaatcta 26820
aatcatgaaa atgaattaat ccaacattat gggcatttac aatatgactt ggaagaatac 26880
gacaagcgat atgtttagaa acaataccgg ccattaaatc tctttttgtt ggaaagacgc 26940
gagaatcttt gttggcgttt tctgtattta attctttatc tttatttgaa ataaaattta 27000
aaacatcttt ttctaaagac ataattctaa tttatccttt tgaaattctt cgtctaaata 27060
tgggttccaa cccattttaa accttttgat gaaattatca attctaaatt tcggtaagtt 27120
taaatccgca aaaatagatg atttactttt aaaatctgga cctaaataat catataaaat 27180
ttctgcgtat tttaaccata atatacaagt accagattta attgcgttcg gagttttcca 27240
aggttttaca ccatacatcg gatttccact tcctttatgc ctgatagaag atgaaattcc 27300
aattttaatt ttagcttcct ttgtatgcga aaatccacga tgcggatttt ctttccagta 27360
ttttttagaa gcttctgata ttttctttct ggctaaatta gtatgatgct ttccataaaa 27420
tccatgattt ttgcctttat tacaatttct tttaatcatg gttattgatt gcttttctct 27480
agtttcttta gaaggagaaa taccatatgt cgtaaatttg ccatcagcat atgctaaatt 27540
aaaatactct ttattccata catctttttc tatattcttt tgaaattcag cttcaatgct 27600
agttatttgt tcatctccga ctaattgaaa atataatatt tcaactttcg gcgtttcttt 27660
caataaggct ttttgaaatt cggaagatga cgaagacgaa taataaaatt taccattttt 27720
atcaataata ttcgttccgt caaaagtgca attggtttta cttccaatgt aataatatgg 27780
tggggtttta gcattaattc tattaataaa tgatagttta tatactacat tcattttaaa 27840
ctctttctaa gctgcttctt aaatgaagct attaattgtg ttttagtgtc agattcatta 27900
tattcaaatc ctctttgaag catctcagcc atcatttcct cttttcctaa acgagaaaat 27960
tcctttgatt tatctccaac gaagttaggg tgaatattat tttgggtgta atcggatttt 28020
aaataagtaa gtaaattttc tagccattca agataatcaa caccttgtcc ttttaagcca 28080
gaacgattaa atttatgttt catttgacct tctgcagcat tgcagagatt acagagcaat 28140
ccacgtacct ttccagcttt cggtccattt aattcatggt catggtcaag atgattagct 28200
tgaacatcag gatttaattc tcgttggcaa attaagcatt taccgttttg tgcattataa 28260
aatttttgtt tttcttcttt gtataatttg ccagtcaata acataataaa acccttacct 28320
tgaatagata agggtattta ttattttcaa gtattaaaat gctcggtcag aaaaagaaat 28380
ttgagtttca agccattcaa tatattctgc cgcagcttgc atcaaatttc cttcataacc 28440
atcgttattt tcttgtgcag ctaatttagc taatgcatat gaaatgcgtt caccttgaaa 28500
agcggcttta ggtttatgaa tagcttgatc aactcgttct acaacttctt caatttcgcc 28560
attttctact gattcagtat tccataagca ccaataggca gttggcttat cgtagatgtt 28620
aataatcttt ccatcagaaa gttcaatttc aataattcca atatcaggtt ctatatcatc 28680
ttcacattct tttacaagtt cacgaacttt aaatacagta cctgcgctaa gttccggcca 28740
gtaattacac agctctttat cagcacgatt aattctaaac cacttatcta ctgtaatcat 28800
gtcccatctc catatcaatt atgtcattta ttataggttc attatatact gtttcttcat 28860
cagtgtaaac cggttcttcc ggctctggct ctacagtttc ccatctaacc gcccaccagg 28920
gtttaactcc gaagcttatt aagttcttca taatcaatcc aggattctag tcctgatggc 28980
aaatcagatt caatttccca aagaagttct tcaattttat gaagacgatc taattcttca 29040
gcaggaatag taaccattga cggagctctt gctacattaa tatcgtaaat catatttacc 29100
ccagtttgac catacaatcg ccatatttcc atttagaaat agacttttca ccgttagaat 29160
aataaacttc gagtttagca cggttatttt taatttgaat aaccttggct gtcatcaaag 29220
ttccata 29227
<210> 2
<211> 545
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 2
tattctggta gaaaatacac gccttcaatt ccagatgcca gtaaacttcc taccgacaca 60
attaaaatga ttgatcgcat actagaccaa tctaacagca tttataaaga aatgcctcca 120
gccattcaaa gcacgataga tgatattact gggatgtttt accagagtaa gtatcttctt 180
tccctcgaat aacattagtc tccttcggga gacttttttc attttaccgg tttacttttc 240
gtttgagccg tggtactata caaccatcgg ataaagagga gaacatcatg aaaattgaag 300
cacttaatca agaaggaaat atctacgtca tcattaatgg tgattttttc gtcgacatgg 360
atgaagttac tagtgaagaa cttgtagaac ttcttaagaa acgttataat atgtgtgatg 420
aagttgcaac tcacatggcg tgtgcaatat tctctctttc atatgtggtg gaataatgat 480
tagtatcgaa caagcggata agattaaaga attggtagct ttaattcgta aagcagatga 540
ggaac 545
<210> 3
<211> 4686
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 3
gaacttgaag ctaaagttga taatgcttta gaagcgttag atatgtttct tgatgaaatt 60
atcgatcata atacgagagt ttaagtatgc taacacgtga acagtttgaa aaaatcatta 120
aattagcacg tgatattgaa atagattcat atcaattagc agttgagcat tgtgaaggat 180
attcatacga cggtatagaa gcagctaaaa aggatttgga taaatccaaa gctaagttag 240
ttcaatacct tgaaatgatt aggtggaata atgaaaactg aaaagcagat gtttttaatg 300
aaactaattg aagaatatgc taatgcagtt tctgaatatg agtattctgc tcgggaaaga 360
ggtacagctt tcgcaaaaga agaaatgaaa atcatggttg atgctcacac aaagcttcag 420
aattttattg aaaacgtcat ttaatggttt acaagttggc aaggttatgg tatagtaatc 480
ttgtcaactg tcaaggagaa gagaatgaaa attttgtttg ttgtgtatgt gatgattcaa 540
tataattacc caatgtttac ttataatctg gtgaacaaca ttattgatat tgaaacgatt 600
agtattagaa gttagttcac tttttggtga attggctata gaaaaagtaa ataatatgta 660
tcgtttgacg caagaagacg atatgctata ttttacgcct agcgaaatta ttcatttaac 720
ccaaattgaa aaaccttaca ctgataaaat tgtaagcatt aatgatgagc ataaaattca 780
tttctattct ttatgcccag gatttaatat tgaaagcgag tcaatatgct tatcaattaa 840
taattgggat aattttataa cttacattaa atatttttat tattctaatg aaagaaaaca 900
tagtttaaaa tggcttaaaa attgcaatgc tattattact aacgcttgcg atcagaatga 960
tgaaattgtt ttaaatgtat caaaatgcta tgaagaagga gatgtcttaa ctattcgtca 1020
aattgatgat tctcgagcgc atattgtcac atttaccaaa gacgaagcta ttgcgttaaa 1080
gacttatctc gattctgtta ttccaactat gatttcaaag tgaggaaata tgtttatttc 1140
aagtggaaca gacatgtgtt ataaatgcaa agcaaaatta aatgagacga agaaccaatg 1200
aattatacta aagtatataa taatttaatt aagaaaggaa aactcagaaa attagataaa 1260
tctaaattaa atttttatac ggaaaagcat catattattc catcttgtat tggtggtaat 1320
gatgattctg ataatctagt tttattaaca gctagagagc attttatagc ccattggctt 1380
ttagctaaaa ttcattataa ttcgcctgga ttaatttatg catggtggtc attttataat 1440
tttggagaag attctttagg aagaaatctc aaattaactt caagaggata tcagttagtt 1500
agagaaaaat tttcaaaaat acattctaat acaatgaaag aaatgtggaa gtctaatgaa 1560
tacagagaaa aacgttcgat aacattaagt cttcctgaaa taagggctaa aatttcagaa 1620
tcccagttag aagcacaaaa caaaccggaa gttaaagaaa aaatatctaa aggggtgaaa 1680
gctgctttta aacgaccggg agttaaagaa aaacactctg ctgcagtcaa aaaatctttg 1740
aataattttg aaactaaaaa gaaacaatca aattcatcta aaattagaca aagaactggt 1800
aaacattggc aagactatga cttactttat aagttatgga ttaaattaaa tagacctaaa 1860
cgtgggtcat tcggaactta tataagtaaa ttaggatatc caaaatctaa ttatcatcga 1920
ttgattgtac aatttaatga agattatgaa aggtctaata atgaaaactg tagttaagtc 1980
ttattttggt agtcatcttt atggaacttc tactccagaa tctgatgtag attttaaaga 2040
aatctttgtt cctcctgctc gcgacattct tatcggaaat gttaaagagc atatgagtaa 2100
aaacactaac aacacatcat ctaaaaacac taaagatgat attgaccatg aactatatag 2160
tcttaaatat ttctttaaat tagcagcaga tggtgaaact gtggcattgg atatgctcca 2220
tactccacct gaactggtag ttaaatctga tttacctgat gtatggaaat ttatccaaga 2280
caatcgttca cggttttata caactaacat gaaatcctat ttaggatatg tccgcaagca 2340
agcttctaaa tacggtgtca agggttctcg tttggccgca ttacgtgatg tattgaaagt 2400
agttaatcaa atccctgacc agtgggttga ttaccaagaa gacggttcca ttaagcagcg 2460
tcgcactaaa gttgaagata ttaagcatcg tcttccagaa aacgaattct gtgaatgggt 2520
gttccataat catgagaaaa caggcccgca aacgttctac actgtgttgg gtcgtaaata 2580
tcagacaacg ctttctctta ttgagcttaa gcagtcactg aacaaattag atgctgaata 2640
cggtgaacgc gctcgtaagg ccgaagccaa tgaaggtatt gactggaaag ctctgagcca 2700
tgcttgtcgc ggtggactcc aactattgga aatttacaaa actggtgact tggtttatcc 2760
acttcaagac gctccattta ttctcgacgt gaagttgggt aaacatccat ttaaaacagt 2820
tcaagagttt ttggaagatg tggtcgatca agtagaagca gcatctactg aagcttctaa 2880
gaacggtatg cctaaaacag tagacatgag tttctgggat gacttccttg agaaggtcta 2940
tcttgaaaac caccgaagtt attataaatg atagggagcc ttcgggctcc cttttttatt 3000
tcaaaaattt tttcacaaaa ctgtttacaa gcataaagct ttatggtact atacaactat 3060
caactgatac ggatttgggg aataaaatga aaactacgtt aattgaagta aaaaagttga 3120
ttgacacaga agaaatttca gcttattttg aaaatttctt agaagatgca actgaagata 3180
acgcagttta tctcgctcag aaaattatag aaacatattt ggagcagaat caatgacagt 3240
ttacgtagat gttttaatga atcatggatg gaaacttcgc ggtcatccaa ctaaaaattg 3300
tcatatgttc actgatggag atattgaaga gcttcataaa atggcagaag caataggaat 3360
gaaacgttct tggtttcaag ataaacgcat taaacattat gacttacatg ctcggcgacg 3420
ccaaaaagcc gtagaacttg gagctgtaga agtatctcgt cgcgaagcag taaaaatttg 3480
gcaaacatta aaataaattg tttacagtag ggtagtagtg tgatactatt accctatcaa 3540
aacaaatgtg aaattggaga ataaaatgaa aactgtaact atcaataagg gtatctactt 3600
tggtaaagaa atctctggaa cttttgagct cttaggtgaa tggttccctg ataatgctcc 3660
ggtagatgca caaggagatg gcaaagtttt tgttgaaatt gacggtaaac gtcgtggtgt 3720
ttgggtttac aaatcagaca tttcatatga tggtgtaaaa gttgaagaag ttaaagaatc 3780
gtatgaagat atgaaaaccc gcattaataa aagatttaat gttatgggaa tgatgacgaa 3840
tggtattatt aacggaaaca ttcgttcatt aattatctct ggtgcggcgg gtattggtaa 3900
aacgtattct ttagataaag ctttgaataa agcaaatgat aatggataca ttgaatataa 3960
aagcattaac ggtaaaatct ctggtatcgg tctttatgaa cagctctgga ataatcgtga 4020
agagaattct gtccttttga ttgatgatgt ggatgttttc tctgatatgg acattcttaa 4080
tcttctgaaa gctgctctgg acactggaga gacccgtaaa gtctgctgga gcactgcatc 4140
ttcttactta gaagaaaaag gcattgagcg tgagtttgaa tttaaaggaa cgattgtttt 4200
tatcacaaac gttgacattg accgtgaatt agaccgtggt actaaacttg ctccacattt 4260
acaagcatta gtgtcccgct cagtttattt ggatttgggt gttcacgcta atgaagaaat 4320
tatggtaagg gttgaagatg ttattctttc aaccgacatg atgcaaaagc gcggtctttc 4380
tgatgaagaa acttataaag cattatcatg gatgaaagtc aatgttaacc gtttacgcaa 4440
tgtttcactg cgtactgcac tttatcttgc tgactttatt atgactgaca aaaacggttg 4500
gcaagaaatc gctgaggtta ctcttctgaa ataaattcat aagaggcctt ctaagacaaa 4560
aaggcagttc agaaatagat tatatggact gccattaaaa agatgactag aattaaactg 4620
gtaaatggag gtaatgatgt tatactcaaa ggctcgtgaa atttacgaaa ctaaaattaa 4680
agaagc 4686
<210> 4
<211> 2468
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 4
aaagcctatc ccaaaatttt agaaatagat aaaaccacta ccgagtacgg ttctcgtgat 60
aaattaggcg atatgtctat tgtttttaaa cacagtccta caggatttgg tatatgctat 120
aacctttata cgcaatacga accgggtcct aatcttgatt atggtgcttt agtaaactgc 180
atgatagaat taaatctaca ggcagaaacc cttttgttta aaccagtaat ttatattcca 240
cgcataggtt gcggtattgc tggcggtgat tgggataagg tttctaaatt aatcgacatg 300
tttactcctg atattgattt aatagtggtg gattatgaaa gcacattacc cgcatccgtt 360
tgaccctaaa aacaaagcag aaattattcg tcaatgggaa cgcatttgtc gtactaaatg 420
cccaattaat agtccgcatg atgtagataa agactacatt ggaacattcg ttgaatatac 480
ctttattgat aagaaaggtc gtaaacaaca cgtagaagaa tattgcttaa aggttacatg 540
gttatgagcc aaactagtat tcttaaaaat gcccattgtg aaaagtgtaa atggcctgtt 600
gtttttgctt tatgtaatga tgaaatggcc tgtgatttcg actattggtg ctattgttct 660
aataaaggat gcatcaatca taaaggtgaa ggattttatt caggatttta tccttatcct 720
gatttcgtta aagaaggtaa accaaaatga atgatgattt aaaatatcaa ttattacgtg 780
aacttgatgt tttgattgaa ctttctgcac aaaaaggatt tataattgga tcgggtcaaa 840
aagaccccaa cggtcattca atcgtagcgg ttatgaatca gaaacgagtc attttaaaac 900
ttttggggat tgacatactg tgagcctaag caaagaacaa aaagataaat tgtttgagct 960
tatccatgaa cttctagatg agcatacaga agcaaacacc ttttatgatg aatacggccc 1020
gctatctccc gaacagcaag aagaatttgc tgaccggttt gataagaaag aaaacgaatt 1080
aatagcttat gtgaatacgc tttaagaagg tgatatggcg agtttaattt ttacttatgc 1140
agcaatgaat gctggaaaat ctgcttctct tttgactgct gcgcataatt ataaagaacg 1200
tggaatgagt gtattagttc ttaagcctgc tattgatact cgcgattctg tctgtgaagt 1260
cgtttctcgc attggaatta aacaggaagc gaatattatt acggatgata tggatatttt 1320
tgagttctat aaatgggctg aagcacaaaa agatattcat tgtgtatttg tagatgaagc 1380
ccagttttta aaaactgaac aggtgcatca attaagccga attgtcgata catataatgt 1440
tcctgttatg gcttatggtc taaggactga tttcgctgga aaattatttg aaggttctaa 1500
agaacttttg gcgattgcag ataaacttat tgaactaaaa gcagtttgtc attgtggtaa 1560
aaaagcgatt atgacagctc gattaatgga agatggaaca ccagttaaag aaggtaatca 1620
aatctgtatt ggtgatgaaa tttatgtttc tttgtgtaga aaacattgga atgaattaac 1680
taaaaagctt ggttagtaca aaagttataa ataggtttat ctaactaaag gggtatatat 1740
gctacaatta actgaaaagc aacttcgcaa tcttactgtt cttcaattag atgaaattcg 1800
tagggaagtt ggaaatatca tttcagcttt gcgtcgagaa gtatcgctca accaatctcc 1860
ggcagactat actagattgc gaaattttga aaaatacctt gataaagtta aggccgtgca 1920
tcggcataaa gtaaatacag gacaaaaatg ataggaggcc tttatggcct taaaagcaac 1980
ggcactattt gccatgctag gattagcgtt tgctttatct ccaccgattg aagcgaatgt 2040
cgatcctcat tttgataaat ttatggaatc tggtattaga catgtttata tgctttttga 2100
aaataaaagc gtagaatcat ctgaacagtt ctatagtttt atgcgaacga cctataaaaa 2160
tgacccgtgc tcttctgatt ttgaatgtat agaacgaggc gcggagatgg cacaatcata 2220
cgctagaatt atgaacatta aattggagac tgaatgaaat tcagcgactt ttcacaaagt 2280
ggaaaacctt caaaggcaga tgaatactta ggtttattaa tggctgcaca agcttatttt 2340
cattctgcac attttgaaac taaaagttat gctagacaca aagcatacga ttttattttc 2400
tccgagttgc cagatttgat tgataaattt ggtgagcaat atttggggta ttctggtaga 2460
aaatacac 2468
<210> 5
<211> 13192
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 5
aggctttcag cataattctt tgcgaattcg cagtcttcac aattatctaa tgcttcccag 60
aattcatcat ataaagcatc aaagataagt cctaaacgaa cttcagcgtc tttgatagca 120
ttcactttac cgattttctc ttcagtgtgc ggcttataac ctttaatatc ttcaatcata 180
ttttacttcc tcaccagtac ataaatcata ttcaactaaa cgaataggtt catgaatgcc 240
atatccttga acagaaattt ctgtcgtagg ataaattcca ctaatatcac ccatgttcca 300
cgcttcatta aattgctgtt cgcctgaatt actaaaccat tcggcgaaag catttagcac 360
atctttagaa ccttcaataa ttatctttgc cattacagac tctcagtaaa ggtacgagcg 420
ataacgtcgc gctgctgttc cggagtcaga gagttaaagc gaactgcata accggataca 480
cggatggtta gctgcggata tttttccgga tgcttaactg catcttccag agtttcacga 540
cgcagaacgt taacgttcag gtgttgacca ccttcaattt taactgtagg ttgtgtttca 600
atttcaattt cacgggcatg caaaccatag aaaatttctg ggtctacaaa agagtcctct 660
ttaaaggttt tagaaacaat aattcgcgct tgaataccat cttcaaaata aatagtacct 720
ttatgtgtgc cttcaagaat ttgatatgct ttcatataaa cctcaattag aaaataaatt 780
tatccaagat tgttctttaa ttaaaaatgg ctcagaatca tatgccatta aactctgtgt 840
gattagtcct ttaaaaggcc catcaataaa ttccatagta aaatatggaa ttttattcat 900
tagccgtgca ttaggagccg tgcacaaaac tctgcatcct ttgaatacgc ctttttgtaa 960
tttgtattgc ttaggataaa attcgctcaa aatgttattt tttgctaaaa tttcaaaatg 1020
attcaccaat ttatttttaa tagtttttgg cgaaaaatag agatattcga aaagctgagt 1080
gtctgtcatc attgcattcc gattacgaaa aactgcggac gagtaatacc accaatgcaa 1140
catttactat tacagcagta gtgtacagtg tcaatatgga cactataaat cttatccata 1200
tcaggagatt tgacaggctc atcaattata tacaaaattc gcgaaagcga taaacctctg 1260
aacttgcttc ctttattacc gataaaacta cggacagaat cagtaaataa acgaaaacgt 1320
atatcatcat tagaataacg cgaaaattcc tttttaatgt tatttgcaga aattttagcg 1380
taagctgaag tattagaaag aacaataact gttccaccgt catacaacca attagcggca 1440
aaattagtta ctgcagttga tttaccggat tgacgtccac catctagtcg aagtgtgcaa 1500
tactgcttaa gtaagtcttc aaatggcggg atataatcgt ttttacaaat ttcttctact 1560
ctagcatcag aatggtgtgt aaaagcattc atcagggata gataaggacc agttaaaaat 1620
gttctcattt cttctctcta agtttgggcc attccgtggc gcatgaattg tccatttctg 1680
tatttacccc tccaagtaat tatgaatata ctatcacaat tccaagagaa agtaaacagc 1740
tttatagatt tttatacgcg tcccaagtgc cagtcctaaa cgtagcaatg actcgttttg 1800
cgcgattagg tgtttgatta taccatctac ttttagctaa gttaactgct gcttcatccc 1860
agcgtttttg ttggagcata cgtaaagaat tagtaaatcc tgctacgcca gtttctccca 1920
tttggaaaac catgttaatc aatgcacagc gccgaacagc atcaagagaa tcataaactg 1980
gttttaattt agcatttctc agaattccgc gaacagcagc atcaacatcc tgattaaaga 2040
gtttttcagc ctcatctttt gtaattacac cattgcaatt acgcccaata gctttatcta 2100
attcagattt agcaacatta agtgatggac ttttagtaag caaatgacca atgccagtag 2160
tgtaatagcc ttctgtgtct ttatagattt taagtctaag accttcatct atacgtaaca 2220
tttcaaatat attcataata cctcctaagt atttatagaa ggtatttata aattaaaaga 2280
ggttgttcat tattcggtaa agtgaaggac ccatcacata ttgccactga gtacgaggaa 2340
taagagcaaa agcgtccatc tctggaatca taacaccatc tttattttca aaataagact 2400
cgcaatggca atttctaaac atctcatgct ctactggaat cgtataataa aatagctgta 2460
agtctttatt actagaatat ttaaatacac ctaggtcttc tagaaggtct ggattataat 2520
tgctaaaacc ggtctcttct aagcattctc tttttgcagc ttccagtgca ttcaaatcag 2580
aactttctac acgtcccttt ggaatatccc agcgatgtgc catcattcca ggcttacgag 2640
aaccagtaac ccgacccata aataaatctt tatcttctgt catgaagata ataccagctg 2700
ataatgtttt cattttaatt tcctgcattc agtgataaag ttatttaaat tttgagcata 2760
tttcttttca tcataaatct tttgctgtct gcgtaaacgc catggcattt caatgaacac 2820
acgccatatt cctgataata ctgctgctgt aaaaatatta acaagtatag ttaaaagaac 2880
ccaatctcct attctgtcca ttggattttt tataaaaaaa taaaatacga atgatgatat 2940
aggaagacta atgatatacc acagaagaac cttcttatct gtgaaccaat cagcatttgt 3000
taacttagcg cgaccatttt gaatacacac gaatttatca tctgttacag taaatggctt 3060
agctgcttga taccccattc taaactccct aattaatcgt ttctttgtat cttcggaaca 3120
accattccaa tcaactctat caactggaat gccatcatcc ccatcgtcta agtcatacca 3180
gcgagttttt aaaatcatct gattttcctg caatcactca caaactcttt cattgcttca 3240
ttttcaatat aagaaatgta gctattatat tcttttaatt gtattttgta atcctttttt 3300
ctttgccaat ttattttaaa gttatcataa tgaaaatata aaatgatacc aaagaatgaa 3360
aacaatgaaa taattttagt ataacaaagc tcactccaaa cttctattat atctactgtg 3420
ccgtcgatgt ttaaaataag acagtcaatt aacaatccaa aaagactacc cgcaagagct 3480
gcagccaacg ccacagcaaa aattaaaaat gactcagaaa acgaatattt gactttattt 3540
agttttggct tttgcatcgt gattccttaa caaatttcat aatttcatca aattcatacg 3600
cggcaagttt aagctgatgt tcatttttaa tctttttaca ctgtgctttc caatcacgta 3660
cacgtttacg ataatgtctt ccttgatacc aatatcctat ccaatttaca ggtactaata 3720
aaagtggaac tattaatgga agaattagca ttaacacaag tatttcgcca gaatcaatat 3780
cagtcataac atctaaaaca cctccaataa tcaatagaat tacaaatgat atgagtataa 3840
caggacctat taacacatca gtaggaatta tctggcgctt taattcatac tttaagggtt 3900
tacttggaag atacattgat ggctttgaca tattctctac attccttaac aaatttttct 3960
agtaataaat cactttcaaa attaggattt tccactaatt tatcaaaaag atcatcaaca 4020
atattcaaga tatttctttt actaagaata cgtttatttt catgcttcgt ttcagaatca 4080
actataagag taaagaaata tttctttccc tgaaatttta ctgtagtatc aatatagaat 4140
aaatttgact tttgtaagtt acgtttaaac catgcgtcac ttaaactata aacaccgaga 4200
taatcaaaat cgtcgtttaa ataacatact gtccattcag gagaaatgaa atcagtaaat 4260
tcaacatcaa aatcacacgt caatgaatga attgattcaa tactgttaat aagtattcca 4320
ggacgtatta aagacttttt acctctggaa aatcttccag aaagactttc attagtttca 4380
tatgaagaac cccaataata attacgccct tctgccatac gtttaagaac atttagtaat 4440
tggtctggaa catcaacttg tctttggaat tcttcaaaca ttgaattgaa atcactttgc 4500
attttcattc ctatttactc caagtaatag gggccgaagc cccttatcat tatttcagag 4560
aattaatgta ttcctggaca tcggcagagg tggtttcaac cccagaaata ttaccattaa 4620
aggtttcaac tcgagcaagg gtatcttcaa tatcaacctt agtcagtgct gcaatttcaa 4680
ctacatcatc ggcagtacta attccaaggg catttgctgc acgagtttca cggatatatt 4740
ccaatttaac tgcaagttct tggcgagcat catctaactc aactactttc ttggcgattt 4800
caattcgcat ttcagcatac ccatcagctt tagtagtcaa ctgctcagct gttcgacgat 4860
atagtaaacc gagtttagcg tgcattgtta catcttgacc ttcagaaaga agcttgcgaa 4920
tttcacgctc ttttgattcg gcctgtcgat tcttttcgac aataagttca cgaatacgtt 4980
tttcttcatt aatagattta acagaagcag tttttaggtc tttaatttta tcaagtagtt 5040
ttgctgctgc agcagtatac tgttcttcaa cagatagatt tttagccata gcagaaccaa 5100
gtttagtgcg aataaactca acaattttct tcagtgtgtt catagtattt cctttagtta 5160
attaagggtt ttataatcca tgggagtatt atactccgga taggttgtaa actatttcaa 5220
catcgccttt tgctgcttta taaccttcag cccaagatac aaccgagttt ttatccgaag 5280
attcaaattc tggcattggg ctttcgccaa tgttcacgca gtatgtttct tcattttcgt 5340
caaaccaaat aattaaagta gtcatttatt tctccgtttt ctgtatttgt tttgataagt 5400
ctataataac accgtccttg gtgtttgtac acaattattt catattattg aaatattctt 5460
ctgcgatttc gtcgttatca tggtaaactt tagaagacag tttaacataa ccttcagcag 5520
tgaacatgtt aatcacaacc tttacagtat accactgacc atcttcatta cccattactg 5580
cgtaagtttc aaacatcgga tgatcaggac cgataacttt aatatcattc actgtacgac 5640
caaaatcttc tgaaacacat ttcataaaga agttgaacag ttcaccgtaa ttatccattt 5700
cattctccaa gttgttttct gtatcagtag ttggaagaac agggatgtaa acagttttgt 5760
gaaaaaattt ttaaaaagtt ttagggaatt ctagggcagg gaggggaaat caaaggatag 5820
gataatatat tataaagggt ataaactaaa tgatgtctag agaggcccgg aaaggcctag 5880
ataccaaaaa gccctatcat ttagataggg atttaaaatt atttacctag tttagttatt 5940
atagcttcgg cagcagcttt tagcttagat gcagtgttaa tacgattttt aatttcagta 6000
tacgcatcgc caagaacatc aaggctatca gaataaacac ttacactatt gcgttcgcta 6060
tttgaaatag aacctttagt tttacgatca aaatcggtat acacgtcttg aagatcgcgt 6120
gctgccttct ttgcatcatc caatgcatca agagctttat tcaaagcatt aacgtatttt 6180
ttagtatcga acatattctt agaaattttg acaggtgcgc gttcaggagt agctaaggca 6240
gatttaggaa cctgtttacc agatgccagt ttcttagaaa ttttgaaaaa tgctttattg 6300
aaattatttt cttgactcat cgtaaaagaa ctattatcga tgttatacat ttcaatagct 6360
ttagctttcc acttaagaaa atcgccccgg tcttttgggt ccaagtggaa gaatacttta 6420
gtaagatctg cttcagatgg taattttgct gcttcggtta aaaattcggc ataggttttc 6480
atttaaaatc cttgaaataa tttattggtt attaattatt tattatccgt aacagcattc 6540
tctgtgttat tcaaactaaa aagccccaac ctttcggcta gggctaagaa tgttatttga 6600
tttgtttagc agaccaaatg cggtctttaa taattttttg gaggtcttca acatactcta 6660
ggtcatgagc atgtggatta tctttgaaac tatgagctcg cgcaagtttc tggccttcgg 6720
tcttaattat caaaagttct ttaagaattg cttcatacct agagataatt cctttagcaa 6780
tatttttttc ttgtgctgct ttagggtcag ccttaggagc aggtttacca gaaggttttt 6840
cgaaagccgc accagtagca accaggcttt tccaggcggt ggtaacatag ttacccacaa 6900
agccttcagc tctcatatcg tcatagaact tgtaccgaga ttcgtcagaa gcatctttat 6960
aagaatattt accagcttta atagcagcag ttgctacagc gcgaacatct gaagcggatg 7020
cttctgtcat taaaaattga gcataagttt tcattgttat ttcctatgtt aattaactca 7080
tctatttata ccaaaaagcc ccaacctttc ggtcagggct aagccttgcg gcaaccttgt 7140
cggggttcca cctgctaagg caagtgtttg tacgaaacgc cgggattcga acccggttat 7200
taagtagttg acgctactca atatttttaa aaggccatat ctcgaccata tccgaacgtt 7260
ccgtcaaaaa cgctactcgg cttacggcaa agatatttcc tcgaatcgat aattcggtgc 7320
gccgtttctg ctgtgatata agagggcatc aacaaatcat aaaaatttat taacacaatt 7380
ccttactcag ggaacatcag tccgacgact tgccggtagc gacccggctt cttgtctggt 7440
cgaggcagaa ggattctaac cttcaaccta cggattagaa gtccgttgct ctatacaatt 7500
gagctatgcc ccgtaattaa aatttcattt ttcgaccttt aaaccatcct tctggaattg 7560
ggtcagtttt cttaatacgt ttagaaactt tttcatctaa tgaatgaatc cacatcatac 7620
caaattggga attcttttcg ccctgttggt gtttatttct ggcgtgagat tctttcattt 7680
tattttccta attaattttg atgagataat agtaccacaa ccctatttaa aagtaaactc 7740
attttaaata aattgcgtat tttttataac ccgctgactc atgacgaaga cccttatcat 7800
tagcaaaacg ctcaatgttg ttaatttgat tctggtcaag ttcagagatg tcaaacacga 7860
aaaagttacg tttgttacca actgttacat agtcagttaa atcaatatca tataggtaat 7920
tgatgtcagc aatcaaagtc ttgacagctt tgctaatttt tactttttcg ttaaaagtag 7980
cttcattgat aaattcttta aatgttttca ttttattctc caatcactca tttgttttga 8040
tagggtaata gtatcacaac taaaaccccg tgtaaataac tttgtgaaat tattttaaat 8100
catctgccca atcgagttta agaggctctt tgtattcacg atctaatacg accggaattt 8160
gtacatcacc gctaaatgat aagggtccaa cattataaga caatgttata tgcggtgtgt 8220
aatcatcaaa atcatgtgta gcacctagtg cccgcgcata catgtgtcga cagcgcagat 8280
attcagaatc tagcacaagt acaagagtcg atccatcttg tgttttccat acttctaaat 8340
gtccagaaga agctacttca aaacttccac ttgatggaac atatggaaca tttactctcg 8400
aataacatat agtcgaatga attttttctc taggaactgg attaggaaca cgtaaagagc 8460
gctggagttc ttccagcgcg tcaagtgtta attctgaaaa cttagctgct acataaagac 8520
ccgttgaaaa gtctttaaat tccattattc ttcatctttt gcttcatctg cagattcagc 8580
agtaagattc ttaacagctt caacgatttc ttcaactttg atggtatcgc cagtgatacc 8640
tactacacga gcaatttcag ccaaagttcc ttgcagaatt ttggattctt ccatcagacg 8700
agccgcttgg tcctgcgtat caagaatacg agatttcaga gttacgattt cagcagacag 8760
tttttgttca atagtttgtt cagacattat agtaccttta gtgtattttt aattttagaa 8820
aaaagttctt caagagaacc atcgtttgta attactaaat cgccatcacg aattggcaat 8880
ccagcttctg taatatgagt atcattggat ttttgaccag gacgaactac atgaattact 8940
gtagcaccca tcgccctagc cgcatccatt tcatgatctt gacgagtatc aggaacgata 9000
taataatcat aacctgagtt aaatttatca agataatcta aagcaaataa ttttacccaa 9060
tacatgcggt cgaagttatt aacaatcaaa tccgtaccta gggcttgcat cagacgacgg 9120
actgaccatt gatcttcaat attatttata acgtcaataa tcttgttaaa tgctacggaa 9180
ttaactgatt cttgtccttc gtcatcaaaa aaaacaaaca cgcctttaat tgggctttta 9240
ctattaagat agcaaaatgc ttgttccata atcgtaatta cttctaattt agtcagattc 9300
aaattagtct cacgatcata gtcaattcct tcaaactctt tacgagttaa acaaggatag 9360
tcagtgtttg ctgcgaatac accccatgca taagccaatg catctttaat aggaccagca 9420
agttgatatt tagctgcaga ataattattc atgataaaat ctgcagtagt atcttttcca 9480
ctacgcttta caccactcaa aaagattagt ttcatatgtt tctcctcaaa tttagttaag 9540
attataacac atgaaactta agcattaaac ttctgctata attttaccat ctttttctac 9600
ttgaaaatac gtataaggaa tcgttgctgt acatactaaa gctgggtctg aatcttcagt 9660
gtagctaaat tctacttcag acaggtcaga aacccaaggc ttataaaagt ttattgacat 9720
cacgatttca gttttactgt tatctaaaat gtaaagcgta atgtattcag gacctgtttt 9780
ttgggcagta ttttcgcctg taagatagtt actagttcct aacatccatt catacattcc 9840
tatccacgac ttaagctctt catcaactat aaatctcacg atgagtggat cgtactcaaa 9900
tgtaactcct ggacgctgtg ctcgacccag tccaaatggc ccagtcacag tatcagtaac 9960
aggtatccta attcccggaa taggaactga ctgagcattt aaagtaaaag cagatgtagt 10020
attactatgt ggtattgata ctacaaagtt agttgtattt gcttggttaa aaatttgttg 10080
cagagcttgt gacatatatt cctcataatg ctttataaat gttggtggta taatgggtct 10140
aagtcccttc cattcaattc caattagaac aaacaataga aaagaatgga agataataga 10200
attaatttat tagacttctt aaacgagcag aagtcataaa tggaaatttt tctaaagttg 10260
gctttcgcca atatcttgga tgacaagttg atttaaaatc aagaacaatt ttctttgctt 10320
catcaatagt gttaactcca aagttatcta acattatttt cttttctttt tcccaccgtt 10380
tattagctaa agcagattga agctttttgt ttttaaatgt gtcatttttt ctagaatgag 10440
ttgttccttg tgtcggactc catcctcttc ctaaaataaa tccctcagga attatatctc 10500
catcatgcaa ttttatacat cttttaccat tattataata ttttcgtcca gtttgtgtat 10560
ttgaaatatt atttgcatgt tttcttttta accaaccata aactttatta tttctcctaa 10620
catatttagt tgaaaccgtc atttttatgg ctgcataaga taattttaaa gaatttgggt 10680
gtatttttac taatagctga tgtgcaacat aatgctcttc tggagttaaa tcaaccaagt 10740
tagaagcatc attactaccg cctaaacatt tcggaataat atgatgtctt tctttatatc 10800
cagtaagggc tctattgcga gccctatcaa ttagtgaatt ataaattttt tcataattca 10860
tcgtacattg ccccaaactt tgtttgcaga gaaacgtttt cctttggagt agaagctttg 10920
gagtggcatc aacacaacgt tcgcccagtc tttcggggcg atttcaacaa ggctacccat 10980
aatattaccg ggtatatatg ccttaatcat ttggtctgca cccctaaatc ctttcacttg 11040
actccaatca atttttaatt tcgttttatt agtaatagta ggtgtatttg aatattgctt 11100
taaaagctct tctagaaatt gctgacgagc tttaggtgga atatagtgca agtttaatcc 11160
gtacattaaa ttatgcttac ctaaaccaag gtaaattatc aaaggaaatt tatcccagta 11220
aggaagagtt tccttgtgtt tagcatcata agcaaaagca tatattcgtc ccggctgcgg 11280
gcgaataact ttatgtcctt ttacttgctt aatagtttca gcaaaccact ttctggtttt 11340
attattaatt gctgcgcctt cattacgaat tttatcacgc aatgtttgtc tgaatgaatt 11400
tatcataagc agttgtcttt cttgcttatt gagtttattc attggttttg attcaaattt 11460
ttgaatcttt tcagccgttt taattcctga agcatatttt gacattgctg aagtaaacgt 11520
agagtatttg attcctcttt cttcagcaaa ttgctttcct gtcattcctt ttgctttggc 11580
ctttttgtat tcaagaccta tctgaatcca tttcttttcg tttaatgatt gcttaacctt 11640
tggaacttgg ggagtgcttt cattaattat ttgaaaaata gccattatgc ccccttaaag 11700
ccaagagctc gtaatccatc ttctgttaga attctaaatt ttattccacg cttttcagct 11760
aacgattgtg ctgctttcca tttatcagtg ttaacagaat atgtataaat ttcattcata 11820
aatcttttct tcgctgcggt tgttagatgt gctggtttaa ctggtggttg tgtttctttt 11880
ttaggtttta tttcaataaa aaattcttgt ccagaagaat ctttcatcca aatatccatg 11940
aagtatctac gttttttccc ttctgcatta caaaaataag gaattactgc tgtttcacta 12000
ccccatgcaa taatttctgg atttttatct aaccattcaa aaaagaattt ttcccaattt 12060
gatctatacg taattttttt agggtcacct ctgtattttg atatattttt aggaacccat 12120
tttccagaat atgccattgg attctcctta taaatagata atatatttat aaacaggagg 12180
gcccatgctc tttacatttt ttgatccgat tgaatatgcg gccaaaacgg tgaataaaaa 12240
cgcgccgact attcctatga cagatatttt tagaaactat aaagactatt tcaaacgcgc 12300
tcttgcggga taccgcttac gtacttatta tattaaaggt tcaccacgcc cggaagaatt 12360
agcaaatgct atatatggaa atccacagtt gtattgggtt ttattgatgt gtaatgataa 12420
ttatgatccg tattatggat ggattacttc gcaagaagct gcttatcaag catctataca 12480
aaaatacaaa aacgtaggtg gagaccaaat agtatatcac gtgaatgaga atggtgaaaa 12540
attttataat ttaatatcat acgatgataa tccatatgtt tggtatgaca aaggtgataa 12600
agctagaaaa tatcctcaat atgaaggagc acttgctgcg gtcgatacgt atgaagctgc 12660
tgttcttgaa aatgaaaaac ttcgtcaaat aaaaataata gcaaaatcag acatcaattc 12720
atttatgaac gaccttatac gtataatgga gaaatcttat ggaaatgata agtaataacc 12780
tcaactggtt tgttggtgtt gttgaagata gaatggaccc attaaaatta ggtcgtgttc 12840
gtgttcgtgt agttggtctg catccacctc aaagagcaca aggcgacgta atgggtattc 12900
caactgataa attaccatgg atgtcagtta ttcaacctat aacttctgca gcaatgtctg 12960
gaattggagg ctccgttact ggtccggtag aaggaactag agtttatggt cattttttag 13020
acaaatggaa aactaacgga attgttcttg gcacgtacgg tggaatagtt cgcgaaaaac 13080
ctaatagact tgaaggattt tctgacccga ctggacagta tcctagacgt ctaggaaatg 13140
atactaacgt attaaaccaa ggcggagaag taggatatga ttcgtcttct aa 13192
<210> 6
<211> 660
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 6
tccaactgat gataatccaa atatgtcaat ggctgaaatg cttcgccgtg atgaaggatt 60
aagactaaaa gtttattggg atactgaagg atatccgaca attggcattg gtcatcttat 120
catgaagcaa ccagttcgtg atatggccca aattaataaa gttttatcaa aacaagttgg 180
tcgcgaaatt actggaaatc caggttctat tacaatggaa gaagcggtaa ctttatttga 240
gcgtgatttg gctgatatgc aacgtgacat taaatcacat tctaaagttg gcccagtttg 300
gcaagcagtt aatcgttctc gtcaaatggc attagaaaat atggcattcc aaatgggcgt 360
tggtggcgta gctaaattta acacaatgtt aactgctatg ttagccggag attgggaaaa 420
agcatataaa gccggtcgtg attcattgtg gtatcaacaa acaaaaggcc gtgcatcccg 480
tgttaccatg attattctta cagggaattt ggaatcatac ggtattgaag tgaaaacacc 540
ggctaggtct ttgtctgcaa tggctgctac tgtagcaaag tcttctgacc cggctgaccc 600
tcctattccg aatgattcaa gaattttatt caaagaacct gtttcttcat ataaaggtga 660
660
<210> 7
<211> 1367
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 7
gaagtatcac cgtcaggaag aagaacaaga aaaactgttg ataatttgta tgatataaca 60
aatgctgatg gtaatttttt agtagccggc gataaaaaga ctaacgtcgg tggatcagaa 120
atttattaca acatggataa tcgtcttcac caaatagatg gaagcaacac aatatttgtg 180
cgtggcgatg aaactaagac agttgaaggt aatggaacta tcctagtcaa aggtaatgtt 240
actattgtag ttgaaggtaa tgctgacatt acagttaaag gagatgctac tactttagtt 300
gaaggaaatc agactaatac agtaaatgga aatctttctt ggaaagttgc tgggacagtt 360
gattgggacg ttggtggtga ttggacagaa aaaatggcat ctatgagttc tatttcatct 420
ggtcaataca caattgatgg atcgaggatt gacattggct aatatacttc caatgagcgc 480
tgatttagga gaatccatgg aaggttcttc tatcgacgtc acctttaccg ctcaattaga 540
aacaggtgaa acgttagtat ctataaatat aactagttac gaagaaactc ctggggtttt 600
aatagaagaa aatcgtttat atggaacgta tgaatctgta tttggatttg gaaatgatgc 660
gttgaaatat cgtttagata atgaatttaa aaccgctgct tcatgggaag accttccaac 720
tgattctaat actcagttat atttatggaa agctcctcaa aacctccaga agacattcac 780
ttacgaagta acattaatat atgactacca agaacaaagt gaatccggag gttctggcag 840
taattctagg tcatcttctg atactactga accgacgaat cctccagctc caataagaaa 900
aactcttgtt aaaaattaca caaaaactat agttggaaat tggagtcgtt gggctaataa 960
attgagaagc tatgtgtatg agaggccata aatgtcagga ttaagttatg ataagtgtgt 1020
tactgccggc catgaagcat ggcctccaac ggttgtgaat gctacacaaa gtaaagtatt 1080
cactggagga attgctgttc tcgtagcagg tgatccaatt acagaacata cagaaattaa 1140
aaagccatat gaaacacatg gcggagtgac acaacctaga acttctaagg tatatgtcac 1200
tggaaagaaa gctgttcaaa tggctgatcc aatatcatgc ggtgatactg tggctcaggc 1260
atcatctaaa gtattcatta aataggattt aaaatggcaa atacccctgt aaattatcaa 1320
ttaacaagaa cagcaaatgc tattcccgag atattcgtcg ggggtac 1367
<210> 8
<211> 1820
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 8
ggatatttac ctacttcaaa atcggctgct caaactgaaa ttatgctaac ttgtacagat 60
gcattgaata gaaattacat tactattcct cgtggtactc gctttttagc atatgcaaag 120
gatacttctg ttaatcctta taactttgta tctaccgaag atgttattgc tattcgcgat 180
aaaaataacc aatattttcc gcgtttaaaa ttggcccagg gacgtatagt aagaactgaa 240
atcatttatg acaaattaac acctattatc atttatgaca aaaatataga tagaaaccaa 300
gttaaactat acgttgatgg agcagaatgg attaactgga caagaaagtc aatggttcat 360
gctggttcta catcaacaat ttactacatg cgtgaaacta ttgatggaaa tactgaattt 420
tattttggtg aaggtgagat ttctgttaat gcggcagaag gagcattgac cgctaattac 480
attggaggtc ttaaacctac ccagaactct acgattgtta ttgagtacat cagtactaac 540
ggcgcagatg cgaacggcgc agtcggattt tcatatgcag atacattaac aaatataact 600
gtcatcaaca ttaatgaaaa tccaaacgat gacccagatt ttgttggggc agatggcggc 660
ggtgacccag aagatattga acgtattcgt gaattgggta ctattaaacg tgaaacccag 720
caacgctgcg taactgcgac tgactatgat acattcgttt cagagagatt tggttctatt 780
attcaagcag ttcagacttt cactgattct actaaacctg gttatgcatt tattgctgct 840
aaacctaaat cagggctata tttaactact gtacagcgcg aagatattaa aaattatctc 900
aaagactata atttagctcc tattacacca tcaattattt ctcctaatta tctttttatt 960
aagactaatt taaaagtcac atatgcttta aataagctgc aagaatccga acagtggctc 1020
gaaggtcaaa taattgataa aattgatcgt tattataccg aagatgtaga aatttttaat 1080
tcatctttcg ctaaatctaa gatgttgaca tatgtagatg atgcagatca ttctattatt 1140
ggctcatcag cgacaattca aattgttcgt gaagtacaaa acttctataa aacgcctgaa 1200
gcaggtatta aatacaataa tcaaataaaa gatcgttcta tggaatctaa tacgttttca 1260
tttaattccg gacgaaaggt tgtaaatcct gatactggtt tagaagaaga tgtattatat 1320
gacgttcgta tagtatcaac agaccgagat tctaaaggaa ttggtaaagt tattattggt 1380
ccatttgctt ctggcgatgt tacagaaaat gaaaacattc agccatatac aggcaacgat 1440
tttaacaaat tagcaaattc tgatggacgc gacaaatact atgttatcgg cgaaataaat 1500
tatccagctg atgtgattta ctggaatatc gctaaaatta atttaacatc tgaaaaattt 1560
gaagttcaga ctattgaatt atattctgac ccaaccgatg atgttatctt tactcgcgat 1620
ggttcactga ttgtatttga aaatgactta cgtccacaat acttaactat cgatttggag 1680
cctatatcac aatgacagta aaagcacctt cagtcactag tctcagaatt tccaagttat 1740
ccgcaaatca ggtgcaagta cgctgggatg acgttggtgc taatttctac tattttgtag 1800
aaatcgctga gacaaaaaca 1820
<210> 9
<211> 1128
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 9
tgggaatatt tgtggtcaga gatatataaa agaaacattt atttaaatgc tgacaaacgc 60
gatgctgttg caagattttt tgaatcacgt agctatgatt tttattccac taaaggaatt 120
gaagcatcat acaaatttct ttttaaagtt ctttataatg aagaagttga aattgaaatt 180
gaatctgggg ctggtactga atatgatata atcgttcaat ctgattcttt gaccgaagac 240
ttagtaggac aaacgattta taccgctaca ggaagatgta atgttactta tatagaaaga 300
agctattcta atggtaaatt gcaatggacc gtgactatac ataatctttt ggggcgttta 360
atagcagggc aagaagttaa agcagaaaga cttccaggtt tcgaaggcga aattattcgc 420
ggggttaaag gaaaggattt gcttcaaaat aatatagact atattaatag aagtagatca 480
tattatgtaa tgaaaattaa atccaattta ccttcttccc gctggaaatc tgacgttatt 540
cgttttgttc atccagtagg atttggattt atagcaatta cacttttaac aatgtttatt 600
aatgttggtt taactcttaa acatacagag actataatta ataaatacaa aaactataaa 660
tgggattctg gattgcctac tgaatatgct gatagagtag ctaaattaac tccaactggt 720
gaaattgagc atgattcagt aacaggcgaa gcaatttatg agcctggccc aatggccggt 780
gtagaatatc ctcttcctga tgactataat gctgaaaata acaattcaat atttcaaggt 840
caattgccgt ctgaacgacg taaattaatg agtcctttat ttgatgcatc tggaacaaca 900
tttgcgcaat ttagagattt agttaataaa cgtctaaaag ataatatagg aaatccaaga 960
gaccctgaaa atccaacaca ggttaaaata gatgaatgat tcaagtgtta tctatcgtgc 1020
gatagttact tcaaaattta gaacagaaaa aatgttgaat ttttataatt caattggaag 1080
tggtccggat aaaaacacta tctttatcac atttggaaga tcagaacc 1128
<210> 10
<211> 3888
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 10
tatcgttgtt tagatgttcc tgacacagga atgtgttcaa ttgagtcttt aactaataag 60
gatgaatgcc ttaagttagg tggaaaatgg actccttctg ttaggtcaat gactcctcct 120
gaaggtcgag gagacgcgga aggaacaatc gagcctggag acgggtatgt ttgggaatat 180
ctttttgaga ttccgcctga tgtgtctata aatagatgca cgaatgaata tatcgtggtt 240
ccttggcctg aggaattaaa agaagacccg actagatggg gatatgaaga taatctcaca 300
tggcagcaag atgattttgg attaatttac cgtgttaagg caaatactat ccgttttaaa 360
gcatatttag attcagttta ttttcctgaa gctgcactgc ctggaaataa aggatttaga 420
caaatatcaa taatcacgaa tcctcttgaa gctaaagctc atccaaatga cccaaacgtt 480
aaagctgaaa aggattatta tgatccggaa gatttaatga ggcattcggg cgaaatgatt 540
tatatggaaa ataggccacc tattatcatg gcaatggatc aaacagaaga aatcaatatt 600
ctgtttacat tttaacttaa gggagcccat gggctccctt tttctttata aatactataa 660
actcataagg aaaccgctat gttcattcaa gaaccaaaga aattgattga taccggcgaa 720
attggtaacg cttctactgg tgatatctta ttcgacggtg gtaataaaat taatagtgat 780
tttaatgcaa tttataatgc gtttggcgat caacgtaaaa tggcagtagc aaatggtact 840
ggagcagatg gtcaaattat ccatgctact ggatattatc aaaaacactc tattgcagag 900
tacgcaactc cagtaaaagt tggcactaga catgatattg atacctctac tgtaggtgtt 960
aaagttatca ttgaaagagg cgaacttggt gactgcgttg aatttattaa ctcaaatgga 1020
tctatatcag ttactaatcc tttaacgatt caagcgattg attcaattaa aggtgtttct 1080
ggtaatttag tagtaactag cccatatagt aaagtaactt tacgctgtat ttcatctgat 1140
aattctactt cggtttggaa ttattctatt gaaagtatgt ttggacaaaa ggaatcacca 1200
gctgaaggta catggaatat ttctacatct ggatcagttg acattccatt atttcatcgc 1260
actgaataca atatggctaa attgctagtt acatgccaat cagtagatgg aagaaaaatt 1320
aaaacagcag aaataaatat tcttgtggat actgttaatt cagaggtaat ttcttctgaa 1380
tatgctgtca tgcgagttgg gaatgaaacc gaagaagacg aaatcgctaa tattgcattt 1440
agtattaaag aaaattatgt aacggcgact ataagttctt caactgtcgg tatgagagca 1500
gcagttaaag ttatcgctac gcagaaaatc ggggtggctc aataatgaaa caaaatatta 1560
atatcggtaa tgttgttgat gatggtaccg gtgactacct gcgtaaaggt ggtataaaaa 1620
taaatgaaaa ctttgatgag ctttattatg agcttggtga tggagatgtt ccatattcag 1680
ccggtgcctg gaaaacttat gatgcttcat ctggtcaaac attaaaagct gaatggggaa 1740
aatcatacgc tattaatacc tcttctggaa gagtaactat aaatcttcca aaaggaactg 1800
tcaatgatta caacaaggta attagagcta gagacgtatt tgctacatgg aacgtcaatc 1860
cagttacact agtagctgct tccggcgata cgattaaagg ttctgcagta ccagttgaaa 1920
ttaatgttca attcagtgat ttagaattag tgtattgcgc cccaggacgt tgggaatatg 1980
tcaaaaataa acaaattgac aaaattacca gttcagacat tagtaatgta gctcgtaaag 2040
aatttttagt cgaagtccaa ggacaaacag actttttaga tgttttccgc ggaactagtt 2100
ataatgtaaa taacatcaga gtaaaacatc gtggtaacga attgtattac ggcgatgtat 2160
ttagtgaaaa cagcgatttt ggctctccgg gcgaaaatga aggtgaatta gttcctcttg 2220
atggatttaa tattcgatta agacagcctt gtaatattgg tgacactgtt caaattgaaa 2280
cgtttatgga tggcgtatca caatggagaa gttcatatac aagacgtcaa attagactgt 2340
tagattcaaa attaacgtca aaaacttctt tagaaggaag catttacgtt actgatttat 2400
caacaatgaa atcaattcca ttttcagctt ttggattaat tccaggtgaa cctatcaatc 2460
ctaattctct tgaagttcgt tttaatggaa ttttgcagga attggctgga acagttggaa 2520
tgccattatt tcattgcgtt ggtgccgatt cagacgatga agtagaatgc tctgttttag 2580
gtggaacttg ggaacagtct cataccgact attcagttga aactgatgaa aacggcatac 2640
cagaaatttt acatttcgat agagtatttg agcatggcga cattatcaat atcacctggt 2700
ttaataatga tttaggtaca ttattaacaa aagatgagat tattgatgaa actgataatc 2760
tctatgtatc gcaaggacca ggagtagata tttctggtga tgtaaattta acagactttg 2820
ataaaattgg ttggccaaat gtagaagcag ttcaatccta tcaacgcgaa tttaatgctg 2880
tttcaaatat ctttgatacg atttatccta tcggaactat atatgaaaac gctgttaatc 2940
caaataaccc tgttacatat atgggattcg gctcatggaa attatttggg caaggaaaag 3000
ttttagttgg atggaatgaa gatatttcgg accctaactt tgctctaaat aacaacgatt 3060
tagattcggg tggaaatcct tcacatactg caggcggaac aggtggttct acttctgtta 3120
cattggaaaa tgctaatctt cctgcaactg agacagatga agaagttcta atagttgatg 3180
aaaatggatc agtcattgtt ggtggatgtc aatacgatcc agatgaatct ggtccagttt 3240
acacgaaata ccgtgaagct aaagcatcta ctaactctac tcacactccg ccaacatcaa 3300
taactaacat tcaaccatat attacagttt atcgttggat aaggattgca taatgagttt 3360
acttaataat aaagcgggag ttatttcccg cttagccgat tttcttggtt ttagacctaa 3420
aactggcgac atcgatgtaa tgaatcgtca atcagttggg tcagtgacaa tttctcaatt 3480
agcgaaagga ttttatgaac caaacgtaga atcagctatt aatgatgttc ataatttttc 3540
tataaaagac gttggtacaa ttattactaa taaaactggt gtttctcctg agggtgtttc 3600
tcaaactgat tattgggcat tttcgggaac tgtaacagat gattcgcttc ctcctggttc 3660
tcctgttact gtgttagtat ttggtcttcc agtttcagca acaactggaa tgacagctat 3720
tgagtttgtc gccaaagttc gtgttgctct acaagaagct attgcgtcat ttactgctat 3780
caattcatat aaagaccatc caacagatgg tagtaaatta gaagttactt atttagataa 3840
tcaaaaacat gtattaagca catattctac atatggaata actatttc 3888
<210> 11
<211> 3970
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 11
gcacaaactg taactttaga taatcagcag actcctacag tattttatca ttttgagaga 60
acagcatgag taataataca tatcaacacg tttctaatga atctcgttat gtaaaatttg 120
atcctaccga tacgaatttt ccaccagaga ttactgatgt tcaggctgct atagcagcca 180
tttctcctgc tggcgtaaat ggagttcctg atgcatcgtc aacaacaaag ggaattttat 240
ttcttgccac tgaacaggaa gttatagatg gaactaataa taccaaagca gttacaccag 300
caacgttggc aacaagatta tcatatccaa acgcaactga aactgtttac ggattaacaa 360
gatattcaac caatgatgaa gccattgccg gagttaataa tgaatcttct ataactcctg 420
ctaaatttac tgttgccctt aataatgcct ttgaaactcg tgtttcaact gaatcaaaga 480
atggagttat taaaatttcg tcattgccgc aagcattggc aggtgctgat gatactactg 540
caatgactcc attaaaaaca cagcagttag ctattaaact aattgcgcaa atcgctcctt 600
ctgaaaccac agctaccgaa tcggcccagg gtgttgttca attagcgaca gtagctcaag 660
ttcgtcaagg aactttaaga gaaggctatg caatttctcc ttatacgttt atgaattcat 720
ctgctactga agaatataaa ggcgtaatta aattaggaac acaatcagaa gttaactcga 780
ataatgcttc tgttgcggtt actggcgcaa ctcttaatgg tcgtggttct acaacgtcaa 840
tgagaggcgt agttaaatta acaacaacag ccggttcaca gagtggaggt gatgcttcat 900
cagccttagc ttggaatgct gacgttatcc accaaagagg cggtcaaact attaatggaa 960
cacttcgcat taataacacg cttacaatag cttcaggtgg agcaaatatt accggaacag 1020
ttaacatgac cggtggttat attcagggta agcgtgttgt aacacagaat gaaatagata 1080
gaactattcc tgtcggagct attatgatgt gggcggcaga tagtcttcct agtgatgctt 1140
ggcgcttctg tcatggtgga actgtttctg cgtcagattg cccattatat gcttctagaa 1200
ttggaacaag atacggcgga agctcatcaa atcctggatt acctgatatg cgtggtcttt 1260
ttgttcgtgg ctctggtcgt ggctctcact taacaaatcc aaatgttaat ggtaatgacc 1320
aattcggtaa acctagatta ggtgtaggtt gtaccggtgg atatgttggt gaagtacaaa 1380
aacaacagat gtcttatcat aaacacgctg gcggatttgg tgagcatgat gattctggag 1440
cattcggtaa tacccgtaga tcaaattttg ttggtacacg taaaggactt gactgggata 1500
accgttcata cttcaccaat gatggatatg aaattgaccc agcatcacaa cgaaattcca 1560
aatatacatt aaatcgtcct gaattaattg gaaatgaaac acgtccatgg aacatttctt 1620
taaactacat aattaaggta aaagaatgac agatattgta ctgaatgact taccattcgt 1680
tgacggccct cctgcagagg gccagagccg catttcctgg attaaaaacg gcgaagaaat 1740
attaggagct gacacacagt atggaagtga aggttcaatg aatagaccta cagtttctgt 1800
actaagaaat gttgaagttc ttgataaaaa cattggaata ctcaaaacat ctttagaaac 1860
cgcaaatagt gatattaaaa caattcaggg catcttagat gtatctggtg atattgaagc 1920
tttggcccaa ataagtatca ataaaaagga tatttctgac cttaaaacgc taaccagtga 1980
acatacagaa atattaaatg ggactaatag tacggttgac agcattcttg ctgatattgg 2040
tccatttaac tccgaggcca actctgtata cagaacaatc agaaatgatt tactgtggat 2100
aaagcgtgaa cttggacaat acacaggtca agatattaat ggtcttcctg ttgtaggaaa 2160
tcctagtaca ggaatgaagc atcgcattat taataatact gatgtcatta cttcacaggg 2220
aatacgttta agcgaattag aaacaaaatt tattgaatct gatgtaggtt ctttgactat 2280
tgaagttggt aatcttcgcg aagagcttgg accaaaacca ccgtcatttt cacagaacgt 2340
ttacagtcgt ttaaatgaaa ttgacactaa acagacaaca gttaagtctg acattagtgc 2400
tattaagacc tcaataggat atccaggaaa taattcgatt atcacgagtg ttaatacaaa 2460
cactgataat attgcatcta ttaatttaga gctaaatcaa agtggaggta ttaaacagcg 2520
tttaaccgtt attgaaactt ctattggctc agacgatatt ccttcgagta ttaaaggcca 2580
aattaaagat aatacgactt caatcgaatc gctaaatgga atcgtcggtg aaaacacttc 2640
atctggttta agagcgaatg tttcatggtt aaaccaaatt gttggaactg attctagcgg 2700
tggacaacct tctcctcctg ggtctctttt aaaccgagtt tctacaattg aaacttctgt 2760
ttcaggcttg aataatgatg ttcaaaacct acaagtagag attgggaata acagcacagg 2820
aattaaagga caagttgtag cgttaaatac tttagtaaat ggaactaatc caaacggccc 2880
aactgttgaa gaacgcggat taaccaattc aataaaagct aacgaaacca acattgcatc 2940
agttacacaa gaagtgaata cagccaaagg caatatatct tctttacaag gtaatgttca 3000
agctctccaa gaagccggtt atattcctga agctccaaga gatgggcaag cttacgttcg 3060
taaagacggc gaatgggtat tgctttctac ctttttatca ccagcataac atggggccgc 3120
aaggccccaa aggattttaa atgtcaggat ataattctca gaatccaaag gaactcaaag 3180
atgtcattct aagacgttta ggggctccaa ttattaatgt tgagttaaca cccgatcaaa 3240
tctatgattg catccagcgt gccctagaat tatacggtga ataccatttt gatggactta 3300
acaaaggttt tcatgttttt tatgtagggg atgacgaaga aaagtacaag actggagtct 3360
tcgatttaag aggttctaac gtatttgcag taacccgcat tttacgcaca aatattgggt 3420
caataacatc tatggatgga aatgctacat atccatggtt tactgacttt cttttaggaa 3480
tggctggtat taatggtggc atggggactt cttgcaatag attttatgga ccaaatgcct 3540
ttggagctga tttagggtat tttacccagc ttaccagtta catgggaatg atgcaagata 3600
tgctttcgcc tattccagac ttttggttta attcagcaaa tgaacagctc aaagtcatgg 3660
gaaacttcca aaaatatgat ttaattatcg tagaaagctg gactaaatca tatattgata 3720
ctaataaaat ggttggaaat acagtaggat atggaacagt cggtccacaa gatagctggt 3780
cattatctga acgatataat aacccagacc acaatttagt cggtcgcgtt gttggtcaag 3840
acccaaatgt taagcaaggc gcttataata atcgttgggt gaaagactat gctacagctt 3900
tagctaaaga attaaatggc caaattttag cacgtcacca aggcatgatg cttcctggcg 3960
gtgttacaat 3970
<210> 12
<211> 952
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 12
ttttggtagg ttaatatggc tacttatgat aaaaatcttt ttgctaaatt agaaaatcgc 60
actggttatt ctcagactaa tgaaactgaa atactaaatc cttatgtaaa tttcaatcat 120
tataaaaaca gccaaatatt agctgatgta ttagtggctg aaagcattca aatgcgaggt 180
gtagaatgct attatgttcc aagagagtat gtttcccctg atttgatatt cggcgaagac 240
ttaaaaaata aatttactaa agcttggaaa ttcgccgcat atttaaattc atttgaagga 300
tatgaaggag ctaaatcgtt ctttagtaat tttggtatgc aagtacagga tgaagttact 360
ttatccatta atccaaactt gtttaaacat caagtaaacg gaaaagaacc taaggaaggc 420
gatttgatat attttcctat ggataacagc ttattcgaaa ttaactgggt tgaaccatat 480
gatccatttt atcaattagg ccaaaatgct attcgtaaaa ttacggcagg taagttcatt 540
tattccggtg aagaaattaa tccagttcta cagaaaaatg aaggaattaa cattccagaa 600
tttagtgaat tagaattaaa tcctgttcgc aatcttaatg gcattcatga tattaatatt 660
gatcagtatg ctgaagtaga tcaaattaat tctgaagcta aagaatatgt tgaaccttat 720
gttgttgtca ataatagagg caaatctttc gaatctagcc catttgataa tgatttcatg 780
gattaataaa tattataaac taattaaagc ccagattagg agaaatcatg tttggttatt 840
tttataattc gtcttttaga cgatatgcta ccttgatggg cgatttgttt tcaaatatcc 900
aaatcaaacg tcagttagaa tctggtgata agtttatacg tgttcctatt ac 952
<210> 13
<211> 1887
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 13
aatttacgag cggctacgag gtcgtttgat ttaatagctt caattaaacc ttccattaaa 60
aatcctcttg ttcttggtcg gggtcttgga aacgagcctc tttagactct tcttcaattt 120
gcttggcttc ttgttctatt tcttcatcag tcatctgcaa aatatctttc atagcagttc 180
tgtgagaaat atatttacca ataaatggtt ctgccatggt tagcatatta attcttcgtt 240
ccaaaatttc tgcttctttg agctcagcaa agtagctatc ccgatgaaat tctatcttaa 300
tattatttat ttcatcattc cactcatctt ctgtgattat acctttaagc aaaagatttg 360
ttttaagcgg atctaggaaa acttcttcaa atttatgctg aagctcacga ataaatttag 420
caaacgttaa ttcatcacgt gtagtgctag ttccagaatc aaacattaca ccgccttgtt 480
ggtcttgcgg aatgcgtgaa agaggaacac gtaatgccat ataaagagct tgtctaaacc 540
aacgaatatc ttccatattg ccagtattat cagcaccagg aagagtatca acttctgtca 600
cagctttacc atcacggcgc tgcaaccaat agtcttcggt catagacata ttatgctgtt 660
gattttttat tttacctgtt gatgcatcat atactacacg gtttttcatc gtgttcatga 720
catgttgcat gtgctcggca gctttacgag caggcatatt acctgtatct acataccaaa 780
cacgacggtc aggagcacga gtaatgcgat aaatgactac agcatcttct aataatttta 840
attggttagc aggtttaaca gcacgatgta aatacccgat gatattttta ccgcaacaat 900
cgactaatcc agaatgggca taaactacgg cagctttagg aatttttatt tttgtgccag 960
cttcatacat tctaccatca catgcatatg actcatgggc agtatcatat ataaaatatt 1020
ctttgtaacc tttaactatt tttgtgccag cttcagtttc tgttataatt tcacgaacat 1080
actgaacttg gcgagggtct aatctacgta attcttttat gccttctttt ggacgtttta 1140
gatcaatgat tttatgaaag aaaattcttg aatcaacata ccaacgtcta aaatgatcag 1200
aaccttttcg ttgaaacgat agatgattta atacatcgct aaattcatct aacatcatat 1260
ttttaatttt tgggctaaat ttagatttat ccaaatttaa cgctacgact tcagtatcat 1320
cttcatagac gatagcgtct gaaacgattt ctgaaactgc attatctact tcatagttat 1380
tcatgagatt acgatatgta tcaataagct cacgagtagt tttcattcct ggttcatatg 1440
aaccaaaaat tgtttggaat gcagcattat aaggagaagc agcttcgttc gagcttactt 1500
caaattctct tgctccatca tcaagctttg gggctgtaat ggaaacaaga tcttcttttt 1560
cttggtcttt aaaatttcgt tcgtccattt tagcccatgg agcaaacaaa cttaatacat 1620
taaatttcat tgtattctcc aaatgggaat tatagttata tttataatgg acttctctgc 1680
tttaagcagg atggggattt ctccccattc attttattcc caataatcga gagcgagagt 1740
tacttcaaag gtttggattt cattgtttga atcccaatct aattgaagtt cacccacgtt 1800
agtaggccac agacctttaa tttcaatttc ttttgttact gttttagcgt cacgagcata 1860
ttggcgaaca atagcgctct ttttata 1887
<210> 14
<211> 823
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 14
gtaatttcgt ttccttgccc agcagcaatg ctttgccagt caacaaactt ctgacgtgca 60
tcatgcgcct cgtcattcat tactgtaata gtccagtcat cgaatgtacg atcgcctgct 120
acgttaattt tacggttcat aaatccgact ggaatttttt ctacaatacc agccggtaaa 180
gcagtggctt tacattgaaa cgtaaaattt tgtccaagat aagaaatttc tacttggaat 240
aagttaggtc gagcaaaatc accagattca aacgctcgtg ttacatcatc tacaaacata 300
ttagcctctg tagtatttat atccctatgt ttaacctagg gcatatagaa ttaaagaatt 360
aaggatatag tgtatttata tggcctgccg aaacaggcct ttagaatgca ccgtattaac 420
ctgcaagacc agttaactca tcgaaatctg caccagtagc agttgctacg aagtttaagg 480
taatgtagtt aatgcttcta gccggttgga tgtagaatgt tgcaacaaac tcatttctat 540
caattactga cggagtgtta tttgttgtat cgcaaactac acgatattca taaattccac 600
cgagagcttt aattccctgc aagtactggg aagtttctgt gcggaacgat gaacgagtaa 660
acgcgttgtt taattcgaac aaacgatatt ttgaactacg tccgatattc gttttcaaca 720
tattaaacag acgacgaacg ttaatacgat caaatggaga aggaacagaa gtagctgttt 780
tatcaccata caatacgtaa ccatcaccac ctgtaccagt tac 823
<210> 15
<211> 2893
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 15
taggcatttt gtgaaagata tttgtcatct tctggtttat gttttaacca acctgatgca 60
gcaagaatcg cagcggcacg agctgaagca acacagaacg ttgcagtata agttgattct 120
ttttggatat gcgaaaccat ttcacatacc attcggtata atgaacgacc agcttcaggt 180
gcagatgcat aactcaaatc aatgaatcca gtatcagtaa ttcctgtaac tttatagcgt 240
tttgacactg taatcaaaga ctgcagaata tctttattga tttcatccgc catttcagtt 300
gcaagcaaat cttccaagaa attaggagca tcgaatccat ttgcttctaa atcttgtgct 360
aattcaactg tgatgccagt tttaagttta cgagatttaa ctgcggtttg ccatttatta 420
atctggaatc tagcatccgc aatttcacta tcagagcttt caaatttgct tgttactgca 480
gcatcagaaa atagacgaac ctttaaaaga acgattgcaa tctgaagagc taattctaaa 540
tcgctttctt caatatcagc aaatggtgta tcttctaata ctttataaac gatattatta 600
tatttgaata aatcgccttt attgagagtt aatttagact cttctgttaa ttctgtgatt 660
tgttctcggt ctacgtatcc agcttcgccg gcgtaagtag caccagtttt aaatgtaaat 720
tcgttatctg ggttaaggta tttgatacca taaaaagcag caacaggttg attagttctt 780
tgcgttgcta caatgtcaga atatattaat ttagtggtag cgcgagtcaa agcaacgaga 840
tttgggcgac cgattgagtt gctattcgtt gtggttgatt cgcgcagaag ttcgttgatt 900
ttagccattg cgctttcctt ttggtttata tgatttattt ataccataaa aacaactaaa 960
gggacccgaa ggtcccttaa atcgtcaaag attagatacc tttaacatat acacggcgga 1020
agtaagcgtt tttaccaagg ctattcagaa tagaaggcat accgctctgg atgcgagaag 1080
ccggagcctg agcagcggat tctgcaaatg ggttgatacc gataccgtaa cgagttttga 1140
atcccattac tggttggaag ttcttcggat cggaaccacg cagcggagtc agagctacat 1200
atggagcgta gtaaatacca gcatccattt cgttcggacc tttataacct acagtgaaat 1260
aatcctgttt agcatactgg tcgatatata cacggtattt accacccaga acaccagcaa 1320
atactgactt ggtagtatca gtgttaaagc cggtagccag accctgtgca gcataagaaa 1380
tgccagtatc aactgaagcc agaacgttaa ctacgttacg ggaagcgata atgaagttac 1440
cttcaccacg accggtctga cgagcaattt caactgcttc tttgtcaatc tggaacaaca 1500
gagctttaaa ggattcacct gcccagcgag caccacgaat gtcaattgga tcctggaagt 1560
cgaatacgcc agctttagaa cccggagtca gggtcatacc agatttacca acctgagctg 1620
agtagttaat ccaatcaaca acttcacggt tgatttccag cataatttct gtagccagaa 1680
tgccagacag ttcagcatca gcatccatac cgtgaacagc gcggaggtct tgtgctaatt 1740
caatagagta agcagctttc agctggcgag atttagcttc gataacttgt ttatcgatac 1800
ggaagcccat ttcattccat gggttatcgg tagaaccgtt gaaaccttcc tggagttcag 1860
cgatagaagt agccatacct tcagcgattt ctaccagtgc accagcttcc atttgtttct 1920
taatttcagc atctaattta tctgcatcag ttgcgcttga actaattgtt actacagcgg 1980
aagcttgcag atacacagta ccagtgtcct ggaagaagtg agtatagata tcacctgctg 2040
tggtttgtgt gctagcagcc agagctggga atttcttagc agcaccctga ccagagaaca 2100
ttgcatctgg accatacatt gggtggaatg cttctttagc accagaagcg accgggtctt 2160
taccgtatac tgcacgcagt gcgaatacct ggccagtcgg gctgttcatc ggctgaacac 2220
cacaaatatc gaaagcaatc aggttaggaa tagcacgacg taccataccc ataacagctg 2280
ggccaatctg agttactgcg ccagaagtct gacctgcagc gatgttggta gcattgtaac 2340
cgtggtcacc accgatttca gcttctgtta agaaagaacc gaatgcctga gcaatttttt 2400
cgtctttata ttccggagct gtctggaaat ctttttcctg gttttcaaag attttagcga 2460
taatcgcttg tttgctatta gcaatttccg gtaaaccttc accttccagt aatggcttcc 2520
atttgttcaa aagttcagct ttagttttga tagtcatttg tgttaacctt taaaattaga 2580
aacgagatgc gactttcgca tatacactta caatatcttc tgcaccctgt gcagctttat 2640
cttctacagc ttcagtgacg aaattcagtc cggctgcttc agtatcagga gtatttatac 2700
cctcagtaat agtgctttca tctttattag acttcttcac catttctacg attgcactca 2760
atttacttga gaatgcatct gaataatcca taccttcgac cagagcagag actttttctt 2820
tttgagactc agtcagatct ttagtacttt cgctcaatgc cacttcacgc tgcacataat 2880
tgatatatgc gtc 2893
<210> 16
<211> 728
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 16
atgaatttag aagcttgctc agcgattttc ttctcagctt tttcttcggc ttcttcttta 60
tttttttcta cttcttcttc tgctttttca gcaattttag cgatatgaga ttcagctaat 120
ttaacggcgt gctgcttgac ggtagcttcg aatacagtgc cgaaagtttc ttttgcttcc 180
ggagaaatat taactgattc gaaaatacta tcaagagcaa cggaagcatc aattttctgc 240
gcttcggcaa tcagttgttc tttaagcatt ttgtagtcct gttgtttaga taataatatt 300
tataacgctt ttttcatggc ctctgcgaga gccatatagg cgtcatcggc acttgtatcg 360
gcttccgccg tctgtgattc ggtaatttcc ttaggagtta cccatgcatc tggagcactt 420
ggaccccata ctgcatcaac acctacagtt aatttgaatc cttcgtttac gatacgataa 480
cctttatttg tgtcagtcaa tgaacctaat ccacgagaag aaactcctgg aatccatccg 540
gcacgaatat tagctgctaa tttatctcca ggaccatggt caccttcaat aacacgagct 600
cgtccgtata cgtcatttcc tttccaccac atatcttcta taatgatagc ggcttgcatc 660
gggtcaacat tagcgcgtgg aggatgattt aattctccga gagcttgttt agttaaaact 720
tgctcatt 728
<210> 17
<211> 3865
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 17
gtaataaata tatctatatt tatactgagg aaatattatg atagataaag attatattgc 60
agagctgaag gctcttgatg ataataaaga agctaaagct aaattagctg aatatgctga 120
acagtttggt ataaaggtca aaaagaataa atcttttgat aatatcgtta atgatattga 180
agaagccctc cagaagctcg ctagtgaacc tatgccagag actgatgggt tatctattaa 240
agacttaatt aatgctgctg atgctgcaga gggattaaaa tatgacgatg aagaagtcaa 300
tccagaggca gcacttctga ttgattctcc ggttaaatct gacattaaaa ttgaagtagt 360
agaaacggat aaaattcccg aaaataccga tgttttgatt gaagatactc cttttgttga 420
agaaaaattt gaacaggctg tagctgagat tattgaatct gaaaagccgt ctgtatttac 480
tcttccggaa aactttagtc cgaatcttca gctgattgga aaaaatccag gattctgcac 540
tgttccttgg tggatttatc aatggatagc tgaaactccg gattggaaat ctcacccaac 600
tagttttgaa cacgcgtcag cacaccaaac tttatttagc ttaatttact acattaaccg 660
tgacggatca gttttaattc gtgaaacacg caattcttct ttcgtaacat taaaataagg 720
ataacttatg acttttacgg ttgataactc ctaaaacacc tactggagtt atagatcaga 780
ctcagcagtt tactgctaca cccagtggtc aaactggaga tggacctatt acatatgctt 840
ggagcgtaga taatgttcca caagatggag ctgaagcaac ttttaattat gtattaaaag 900
gacctgctgg aacaaaaaca attaaagttg ttgcaacaaa tcaagttgcc gatagtagtc 960
ccgaaacagc agaaattact acgactatca cggttaaaaa taaaactcag tcaactacgt 1020
tggcagtaac tcctgatagc cctgacgctg gagtaatctg aaccccagtt caatttactg 1080
ctgccttagc ttctcaacct gatggagcat ctgctacgta tcagtggtat gtagatgatt 1140
ctcctgtgga cgaagcaact agcgctacat tcaattacat tcctaccaca agcggagtta 1200
aaaaaatcaa gtgtgtagct caagtaaccg cgacagatta tgatgcacta agcgttactt 1260
ctaatgaagt atcattaacg gttaataaga agacaatgaa tccacaggtt acattgactc 1320
ctccttctat taacgttcag caagatgctt cggctacatt taccgctaat gttactgatg 1380
ctccagaaga agcgcaaatt acttattcat ggaagaaaga ttcttctcct gtagaagggt 1440
caactaatgt atatactgtc gatacctcat ctgttggaag tcaaactatt gaagttactg 1500
ctgtcgttac agcaactgat tatgatagca aaacagttaa aacaacaggt caagttcagg 1560
taactgataa agttgctcca gaaccagaag gtgaattacc ttatgttcat cctcttccac 1620
atcgtacttc agcttatatc tggtgcggtt ggtgggttat ggatgaaatc caaaaaatga 1680
ccgaagaagg taaagattgg aaaactgacg atccagatag taagtactac ttgcatcgtt 1740
acactctcca gaagatgatg aaagattatc cagaagttga tgtccaagaa tcgcgtaatg 1800
gatacatcat tcataaaact gctttagaaa ctggtatcat ctatacctat ccataatcat 1860
aaggggcttc ggcccctttc ttcattttga aagcacacaa aacacaatca gaaaatgatg 1920
tatataatgg caccaactcg ataacatgag attgattatg agaactgagg ttgtggtgtt 1980
tactcttcat gagtctggaa agtcattcat tgaaattgct cgtgaattaa acttacaggc 2040
aaaggaagtg gctgtattat gggctcgagc tatgactgct aagaataaat ttgagactcg 2100
agaaaaagtt gtctatagaa aaagacatat caataaaaag gtgaaaaatg gaacagtatg 2160
atctttatga aaatgaatct tttgctaatc aattgcgaga aaaagcactt aaaagtaaac 2220
agtttaagct agagtgtttt attaaagatt tttcggaact tgctaataaa gcagctgaac 2280
aaggtaaaac acattttaat tattattgta ttgctcgtga taaattgatt actgaagaaa 2340
ttggtgattg gctgagaaaa gaaggattta gctttaaagt caatagtgat cagcgtgatg 2400
gtgattggtt agaaattaca ttttgaggat taattatgtt taaaaagtat agcagtcttg 2460
aaaatcatta caactctaaa tttattgaaa aactttataa cctgggattg actggcggcg 2520
aatgggtagc tcgtgaaaag attcatggaa caaacttttc gttgattatt gagcgtgata 2580
aagtaacttg cgctaaacgt actggtccta ttcttcctgc tgaagatttc tttgggtatg 2640
aaattattct aaagaattac gctgattcca ttaaagcagt acaagatatt atggaaacct 2700
cagcggttgt atcttatcaa gtctttggcg aattcgctgg acctggcatt cagaagaatg 2760
ttgattatgg cgataaagat ttttatgtat ttgacattat tgtcactacc gaaagtggtg 2820
atgtaactta tgttgatgat tacatgatgg aatcgttttg taattcattc gggtttaaaa 2880
tcgctccact tttgggtcgt ggtaaatttg aagatcttat taaacttcca aatgatttgg 2940
attctgttgt tccgtcttat aattttaccg tagataatgc aggtttaatt gacgctaaca 3000
aatgtgtttg gaaagctgaa gtaaaaggcg aagtatttac cgctgaagga tatgtattga 3060
aaccttgtta tccttcttgg ctgcctaatc gcaatcgtgt agccatcaaa tgcaagaatt 3120
ctaaatttag tgaaaagaaa aagtctgata agcctattaa agctaaagtt gaactgtcag 3180
aagctgataa caaattggtg gggattttag cttgttacgt tacactgaac cgagtaaata 3240
acgttatttc taaaattggc gaaattggtc ctaaagattt tggaaaggtg atgggactaa 3300
ctgttcaaga tattttggaa gaaacttctc gtgaaggtat tactctgact caagcggata 3360
atccttcttt gattaagaag gaattagtta aaatggtaca agatgtactt cgtccggctt 3420
ggattgagtt ggtgagctaa ataaaaaggg accgaaaggt ccctttgttt tattcatcaa 3480
cgataatttt tggtagctta acacctaata aaacagacaa atctgaacga cccgccattt 3540
tatccatgtc tccaccgtca attattcttg cttctttttc atcttttgct acggtataag 3600
gatttgctga taaagcatat ctaactaata aaccgataga tggttgtaag ctttctggat 3660
caacaacaac tttaaatgcg cctacatgtt cagggtcatc taagtcgaga ccttctgtat 3720
acggagcata gaaaattgat ccaacaattt ctttttcacc gatattttct actacaccaa 3780
cgattacata atctaatggg ctgttagtat cgcaataaag cggtaaacca ttagctaaga 3840
acccgtaggc attttgtgaa agata 3865
<210> 18
<211> 12358
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 18
ttcaaaaagg caaaagagaa atataacgta atttgttata ttgacgatct cgctcaccac 60
tgcgatcacg cgagtgaaat attaaatgtt cctgtttatt ggatggctcg aggggaacgt 120
gacagtattc caaaaactgc tcagcgagtt tatacatgga acgatgtaga gaataagctt 180
ttttcaccaa aggaaaataa agaaagtttt gatagtgaaa aagctataaa agatgtaatt 240
gaaaagatga ttaaaaacga ttcttttcct tggaacacta cctggagaac tcctggattt 300
aatccttata atccatatca tccatattat acacactcac atcagatgca tccattccat 360
acgtggagtt atattaagcc tggcgatgca gggtatttta atagacttac tagtggtagt 420
gatgataata ttttccaagg agcattttaa tgtttgttgt tcacactatt tatgaaaatg 480
aaggtaatac tacacgtgat tacggtcacg taaatcaatt ttttagatgc aatccagaat 540
tccgagctca aaaagacgaa cgaattttta aaaaaatgtg taaagcaagg tttcatttac 600
gtcaagcact gggtgcaagg aaataaagtt agaaccacgt accacaggtc tttgactgag 660
cttaatgatg tattgattta taatagagct gtaaaccaaa ctctaaagga tgaacaatga 720
ttcttaaaat tctgaacgaa atagcatcta ttggttcaac taagcagaag caagcaattc 780
ttgaaaaaaa taaagataat gaattgctta aacgagtata tcgtctaact tattctcgtg 840
ggttgcagta ttatatcaag aaatggccta aacctggtat tgctacccag agttttggaa 900
tgttgactct taccgatatg cttgacttca ttgaattcac attagctact cggaaattga 960
ctggaaatgc ggcaattgaa gaattaactg gatatatcac cgatggtaaa aaagatgatg 1020
ttgaagtttt gcgtcgggtg atgatgcgag accttgaatg cggtgcttca gtatctattg 1080
cgaacaaagt ttggccaggt ttaattcctg aacaacctca aatgcttgca agttcttatg 1140
atgaaaaagg cattaataag aatatcaaat ttccagcctt tgcccagtta aaagctgatg 1200
gagctcggtg ttttgctgaa gtcagaggtg atgaattaga tgatgttcgt cttttatcac 1260
gagctggtaa tgaatatcta ggattagatc ttcttaagga agagttaatc aaaatgacta 1320
cagaagctcg ccagattcat ccagaaggtg tgttaattga tggcgaattg gtataccatg 1380
agcaagttaa aaaggagcca gaaggcctag attttctttt tgatgctcat cctgaaaaca 1440
gtaaagttaa agaattcgcc gaagtagctg aatcacgtac tgcttctaat ggaatcgcta 1500
ataaatcttt aaagggaact atttcagaaa aagaagctca atgtatgaag tttcaggtct 1560
gggattatgt tccgttagta gaaatatacg gtcttcctgc atttcgtttg aaatatgatg 1620
tacgtttttc taaactagaa caaatgacat caggttatga taaagtaatt ttaattgaaa 1680
accaggtagt aaataaccta gatgaagcta aggtaattta caaaaagtat attgatcaag 1740
gtcttgaagg tattattctc aaaaatatcg atggattatg ggaaaatgct cgttcaaaaa 1800
atctttataa atttaaagaa gtaattgatg ttgatttaaa aattgtagga atttatcctc 1860
accgtaaaga ccctactaaa gcaggtggat ttattcttga gtcagagtgt ggaaaaatta 1920
aggtaaatgc tggttcaggc ttaaaagata aagccggtgt aaaatcgcat gaacttgacc 1980
gtactcgcat tatggaaaac caaaattatt atattggaaa aattctagag tgcgaatgca 2040
acggttggtt aaaatctgat ggccgcactg attacgttaa attatttctt ccgattgcga 2100
ttcgtttacg cgaagataaa actaaagcta atacgttcga agatgtattt ggcgattttc 2160
atgaggtaac tggtctatga aagcttactt agaaacaatt gtcattgctc aaaaagaagg 2220
tggagatgtt tctacttctg tatcacaagt cattctcgaa tttgtagatg cgtatgctta 2280
taataaattt acagaaacat ttgatgccta tgaaaaaggt ccaaagtttg aaatatatcg 2340
tactctctta ccactagatt attaaaggcc ttcgggcctt taattttata aatagaataa 2400
acactagaga ggatatgatg gaactaatta cagaattatt tgacgaagat actactcttc 2460
cgattacaaa cttaaatcca aagaagaaaa taccgcaaat tttttcagtt catgttgatg 2520
acgcaattga acaaccgggc tttcgtttat gtacctatac atctggaggt gatactaacc 2580
gtgatttaaa gatgggcgac aaaatgatgc atattgttcc ttttacatta actgctaaag 2640
gttcaattgc taaattgaaa ggtcttgggc caagcccaat taattatatc aattcagttt 2700
ttactgttgc aatgcaaaca atgcgtcaat ataaaattga tgcttgtatg ctccgtattc 2760
ttaagtctaa aaccgctggt caagctcgac aaattcaagt tattgctgat agacttatcc 2820
gtagtcgttc aggtggcaga tacgtccttc ttaaggaact ctgggactat gataaaaagt 2880
atgcatatat tcttatacat cgcaaaaatg tatcactaga agacattcca ggagttccgg 2940
aaattagtac tgagctcttt actaaagttg aatcgaaggt cggtgatgtt tatatcaata 3000
aagatactgg agctcaagta actaaaaatg aggcaattgc agcatctatt gcgcaagaaa 3060
acgataaacg ttctgaccaa gctgtaatcg ttaaagttaa aatttcccgt agagcaattg 3120
cacaaagtca gtcattggaa tcttatcgta atgaaagtga attattccag aagtatgaat 3180
ctactgcagc taatttcaat aaacctgcta ccgctccttt aattcctgaa gcagaagaaa 3240
tgaagcttgg aattaattca ttagcttcta aaactaaggc agcaaaaatt attgccgaag 3300
gaactacaag tgaacttcgc tattactata aattcgtttc aaaaagtgag gttgatgagg 3360
tttctgaaaa aattaaagat gtaattctta atgcgatcaa aaatgaacca actacttcaa 3420
taaaatgttt agagaaatac gcagcagctg ttaatcaatt ctttgaagaa tataaagata 3480
aatggcttga tacacataat aaaacccgca aaggacagcc agatgaagtc tgggaagaaa 3540
taactaaaaa ttgctggaac gcagcaaaaa ctgtattcct caaacgaatg atttatagtt 3600
tttctggaat tggtgcaggt ccaatgattg atattactat tgcccgtgat ggttctaaat 3660
ataccccatc acaaaagcgt ggcattagag agtattgtgg ttcaggatat actgacatca 3720
ataatcttct tttgggtcgt tacaatccag aacgatatga tgtaatgagt gaaaaagaaa 3780
ttgaatctgc cataaataac ttagattcag cttttgaaaa tggtgaccgt ataccggaag 3840
gcattacagt ttatcgtgct caaagtatga ctgctcctat atacgaagca ctagttaaaa 3900
ataaagtgtt ctatttcaga aattttgtat ctacttcttt aactcctatc atttttggac 3960
gttttggaat tacacatgct ggtattggtc ttttagaacc agaagttcgt aatgaattga 4020
cagttgataa aaatgaagaa ggaataacta ttaatccaaa cgaaataaga gcgtataaag 4080
aaaatcctga atacgttaaa gttcaaatag gatgggcaat tgatggagct cataaagtta 4140
atgttgtata tccaggaagt ctaggaatag caacagaagc tgaagtaatt ctaccgcgcg 4200
gattgatggt caaagttaat aaaataactg atgcttctaa taatgacgga acaacatcta 4260
ataacacaaa actcattcaa gctgaagtta tgactacgga agaactcacc gaatcggtaa 4320
tttatgacgg tgaccgtcta atggaaactg gtgaagtagt tgcaatgaca ggtgatattg 4380
aaatagaaga cagagttgac tttgcatcat ttgtttcatc aaatgttaaa caaaaagtag 4440
aatcatctct tggaattatt gcatcttgca tagatattgc aaacatgcct tacaagttcg 4500
ttcaaggata aatcatggaa cttattacag aattatttga cggcgcttcg gcgccggttg 4560
ttaacttaaa tcctaagcat aaaatacctc aaatttttgc tattcaagcc ggtgaagaaa 4620
gcgtgcttcc tggatttaga ttttgtacat acacctctgg cggtgataca aataaaaacg 4680
ttaagccagg cgataaaatg atgcatgtcg taatgatagg tgttaatgag aaactatcat 4740
tagttaagct taaaaacttg ggtggaaatc caattggtgt cattaatgct gtttttgata 4800
ctgctcttca aacaatgaaa cagtataaaa tcgacgcatg cctattacgc gtactaaaaa 4860
gttcaaaatg tagtttacaa gtccctcgtg ttgtgttata gtagtcttac tgacataaca 4920
tgaggaacac aaaatgaact cttctttacg ctttttaggt caagaacttg tagttgaagg 4980
cgttattcct gctgataatg cttttaacga agcggtttac gatgaattta ttaaaatttt 5040
tggaacagat aaaaagttca gaatttttcc ttctgaaaat ttttcaaagc cagaacagac 5100
tgaaagtatt tttcagggtg tagtaacagg taaatttgag tcagaagctc cggtaaaaat 5160
tgaagtttat attgaagaca gtttagttgc ttcagtttct gctttcattt cattccgcaa 5220
ataaaaatat ggggaccgaa aggtccccgt tgttatattg ctcctaatat tttactctgc 5280
gaattgacaa tccctgtcat agtatactaa tatttgaaat gcttcctgag gttcctccta 5340
gtctactaag tcgtgaaagc gaattagata gtccagtgac acctccacta tttccgagaa 5400
cgctttgaat accatttata gcagcagatt caagccattc aagcgcagct tgcctatcaa 5460
ccgctccagc ctgcatcact ctatacgcaa aagtaacatc aaatgtagtt atttggttat 5520
ctccatcata tgataactca ggagcgctca ctgatattgg aatgcatcca gtgaacatca 5580
ccgcagtatg aggcaatcca ttgcgagaat gaagattaac ctgaatatct gcctcgacat 5640
cttgcggcaa agcacgcagt ccagttactg ggtcttgaac agagttaacc cagtcttgca 5700
ttgcacgata gttacaagct tctgaatcca ttctaaatga aataaccaaa gggtctaatt 5760
ctctcccagt tatacgaata ttaggagaat tatagttcca gtcagtttca taggataatc 5820
tattctctgg catttttaca gagtatatca tcaatccaga tgagttatat gccatgttaa 5880
agaagtcaat taaatatgta ccaactgtaa atgagcctaa taaactctgg acagtacgtt 5940
gactcatggc accaataaga tatttactaa cccctgattt tcttatcagt ttttgtgtgc 6000
cagctgtaat tagcgtggta attccctgat taatatcacc ttgagttaat cctaaccaat 6060
ttgaatttag gcccaagtta ttataagaaa agttgctaat tgaacttatc aacgaagagc 6120
ttttagttga tggagttgtt gcaaaaacgc agctaaacat attattacgt tggaaatctg 6180
cgtttattgc ttgattatta aattcctcta aagaatacat taaaaagtcc ccgcatataa 6240
agaagcacgg tttaacgtga taatttctct catagtaatc tcgagagtaa atgtactagg 6300
gaggtttgga gcaatagcta atccgttaaa gttaccatta ggtgttttat caaatctaat 6360
gctctgtatt tggcatggac caaatatttc cgtttttcca tcaaacttag atgttgcacc 6420
aaagtttttc accatccaaa ctgtcgggtt tgaaactaca agaacgttcg ttaaacttgc 6480
tgtcattttc tcaaatagtg ttttattttt agctgcgtct tccggagata aaggttcaat 6540
taacgtagaa cgataccaat catctaaata cccctttatt tcagcagcgt attgagattt 6600
acctgtttca ccataagaaa aatagttaaa atattgatag atattaataa tagccattaa 6660
atcttctgtt gaacgtggag tcaaatccca tgtaaacact ttagttctat tttcagcacc 6720
accatacata cttctggctg tcgtataaat ctgttcatta ttatcagcca ttataccttg 6780
tgttatactt tccagtgccc caaatactgc ggttgaagca acattactta gcacaccagt 6840
agcagtacct ccgcctctac tgataaggct ttcttgaaca tcattaaatc tatgtgatga 6900
tgtgtcaaca tcagatttag atctcggtaa aagaatgttt gcgacaggag ctttacttat 6960
tgttcctgaa ttattatttg atattaatcc atttgatagt tttgatactg tactactaat 7020
agtgtttcta gctgtactta aaatactcga agatgaagaa gagtagttag atctcatcga 7080
tctaagactt ccagaatccc tagatgacat attgtatgca gtaaataata atccattctt 7140
atatagatct gttacctgga agtcccctgt agtgtcatta ccactagcac gcccagttgg 7200
aaactgggca gtgtatgttt tagttactac ttctgattta gtgctctgtc cggctgaaat 7260
tttctcaccg gactttttaa ttaaatcagt agtcatttct ttaacaattg ccatattatt 7320
ccttaattaa ctccagtcgc atcaaataca ccaggagcag ttgtgcttgt gacaggtgtc 7380
atattatgaa cgacagtatt tttcttaata acattattag tattattgat tgaaggagat 7440
gcttgctgaa caggagcttg ctgtgctttg ttcttttcaa taacctggac ctgtttcgct 7500
tctggcgatt tagcagaagt ttcaggtttg gcattaggct gatttttctt gagctcttga 7560
taagtagcat caattttaga aaatctagca gcaagttctt ttttaactgc cggtgaattg 7620
tttaaatccg ggtcatccat ccgtttttta aggtcttcat aggcagattc aactgattta 7680
accgttgagt ctttactcat atcagctgaa tcagcatatt tttcaaaacg aatcatcgcg 7740
gcacgtgctt cattagcctt cattaaagca ttttttcttt cttcaggtga aagctgcttt 7800
aatttttctt cttctgctgc acgttcttcg tcggtagtta gtgcttcttt attatcaaca 7860
ccgcgaatcc aattagatgc acgagttttc cagttcgcaa ttttatctaa tccttttgct 7920
atcggaccaa ggtctccgtt cattcgttta tcttgataat ttgcaacttt ttcttggtct 7980
tctttattga gagatgctcc agtagaattt tggaaatttt ctaatgctct tccttctact 8040
tcatcagcgg tatccttcat accaggaatg actcgaagaa ttgcagcaga taatttagcc 8100
atacctaatt gaataagttc tcctaaatta taaagaacct ttccaagccc ttcaacaata 8160
gctactgtca atccacccca atctcccgct tcccagaact ttttaatttc atcaatagaa 8220
ctaaagatgc tctgtaataa aggaccccaa gttccggttt cgctagagaa tttagtaaag 8280
tcagtactaa acaaatccca agcctgcgaa aatttatctg accaatattt aaagtgaacc 8340
atcagaagat ctattccaac aacaacagcc aatatcattg cagtcatttt agcggcttca 8400
atagcagcac tgacggtgta cttaaatagc atgcttgata ttttatcagt aattgaaata 8460
gatttcttaa atccaaaatc aactgtcttt gttaatttat ctaaagcttg agataatttt 8520
aagttaaatg cttctttttt ctgtttttct tctggtgatt cttgtttggg ttcaactggt 8580
tgaggggtag ggaaaaaatc agcgtcagga tcattattaa ctgcttcggg agctggtaat 8640
aaaggaccca cagattcagc agtatcatcc tcaacgactt taacaggaat agcgctttca 8700
accgtggcta aactagtccc agtctgttga attccagctg tctgaatttt ttgttctaat 8760
aaactcgtta atttatctaa tttgcttccg agtgattcac caatttcttt attaatattg 8820
ttgccaattt cgacagtttc agcaattaac tcagaaccgg cagtagtatc actcactgcg 8880
ctttctacgt tatcaattgc tccaattatt tcattcgatt tttcttcgac agtttgagct 8940
attaattcag aggcagcttg agcatcatcc aatttcgtag atatatcatt aagtccagat 9000
aaagtattag aagcggattt agccgcttcc tgtgttggtt tattatctga aataactttt 9060
ctacgcatcg tttgcatttc ttgtggcttt ttcattcaaa taatccaata atattgccaa 9120
ttccagttat tggaccatta gggccaggaa ttgctaaagt tgtaaaaata tcatttgccc 9180
attttaaaac gaatgctggc atctcaagaa aattaatttc tttaacttca tcattgacct 9240
taagcaagca tttagataac atatcgctca ccgttaaaaa ttgttcaaat tttccaggag 9300
gtctaaaata aaatgtattt ccttggtatt gaaattctaa tctttggcat acatagacat 9360
cattaatgtc ataagtatag ccatctattt ctttacgaga tttaatcttt ccattaaatt 9420
ccaataaatg aatagaaacg aaatcaactt ctgccggtga taaattcgga caaatagaat 9480
caataagaag ttttaaattt tcatcaggac ctttaacatc ctttaaaatg ttataatgtt 9540
taagacccat tttaggaata gaaacttctt tattacttat tggaagaact actttcttca 9600
gtggtagtat cagatttaaa ttcattttta accttaactg ggtctattgt ttccagtttc 9660
gttgcattag tgaacatata tagatgagtt actgaattat tattggataa ttcatggatg 9720
acttcatcaa cgtaaaattc tgttttaaat tggtttttac tatcattaaa aataatttta 9780
acgccaggtg tcaagttaaa attaccgaca gtagaacatt tagcatagcc atcatattgc 9840
gccatagttt gaagacgaat agcttcttca tagccatttc tataagtcat ttcagaataa 9900
gcacctgacc ttgacactac aatagagttt tcaccctttc ctgtagtaat cattggcagt 9960
gaagaatcta aaaacgaatg agcatagata gtagcatttt tcattgggtc acgtttgtga 10020
ggattcgatt tagtcaacca aacgaaatca tatgctaatg gatattttaa ttcttggacg 10080
aattgaccta ttaaagttgg ctcacctaca atcattggat atggttcttg atttatcatc 10140
atatcatagt ccatcatgtt aactcccatg atgtcttgcc atacaaatac aaatttgtcg 10200
cttcctacag ctagagcaac ttctcttaca tatgacaaat agttttcaaa tgtgctagtc 10260
catggaatat caggaacata agcatttata gcatttattg gtggagttaa taatgtgcga 10320
tcctgataaa ttacgccaag catttccttt atagattcac cggcatcagg gaaaaatggt 10380
ctaccaaatt taagattttc tatagaatga atagttccta attcaatagc aatgatgtta 10440
tcaccttttg aatctactga cacggaaaaa tgcttacatc cataaattcg tgttttaaca 10500
ttattaatat catttgcatt agctacagaa atctgaatta tttcatttcc atccattttt 10560
gtatggatgt ttttagaatc ataaaactgc agcattcctt catttcgacc ataaagagaa 10620
tcacgcatag ttaatgtagt aatagtagca gctaattcaa caaatctatt attactccaa 10680
gcatcgtaac tctcaaataa tttaacgctg agatttggat atccggggcg ttgcaacata 10740
ctcattattg tttatccttc tcaatcagtt ttaatacgaa tccgcgctcg gcaggaatca 10800
ttttcattat tgaatttaag ctataattac tttttacaag cgtgtgatta atttgataaa 10860
aagtaaatat ctcatctgga ttaactaata gcttaaacac atctactata tcagtgtatt 10920
ttttaatgta cttatcacaa cacgacatgt gcaatgttaa attaatagga ttcattgcat 10980
cgagaatttt ttctaatgtt tctatctcga tggcgtcaac aagttctatt tgacttgatt 11040
cactaatttc cttccaatca taccacattt catctacttg aacagaatga atattttcag 11100
taatcatctt tgctttattt tcataaaact cagaaggaaa ctttaattta attttaacat 11160
tagctacatc aaaaacaggt tcctttaatt ctttttgata tatttcaaat ggaactgtct 11220
tttctttttt acattttgga catacgaatg tgactggtac ttttgtttta cctattgacc 11280
ctacaaatac ctgcaaaaat ataaatggtt gccaagtctt tggatagtct ccaaaataat 11340
cagcaattaa atcagcaatt acttcttttt gttcttgtgg tgaccgatgt tctatatcgt 11400
ttcgaactaa caaaaaatct cgataatctt ctaccgtaaa tggtttaaaa cgatgaacac 11460
catctggtaa tttacaacga ataatgtttg ccatagatgc tccttttatt ctatttataa 11520
atatgataaa taaaggagct aaatatgtat gaatacaaat ttgatgtgag agttggttct 11580
aaaataatca actgtcgcgc atttactctt aaagaatatc tagaacttat tactgctaaa 11640
aagaacggtt cagtagaaga gatcgttaaa aagctaatca aagaatgcac aaatgcaaaa 11700
gatttaaacc gccaagaatc agaactatta ctgattcatt tatgggcaca ttctcttgga 11760
gaagttaatc acgaaaactc ctggaagtgc acctgcggaa ctgaaatacc aacccatata 11820
aatctattac atacacaaat agatgcacca gaagacctct ggtatacact gggtgacatt 11880
aaaattaaat tccattaccc taaaattttt gatgataaaa atatagccca catgatagta 11940
tcatgcatag aaacgattta tgctaacggg gaaagcattc cagttgaaga cttaaatgaa 12000
aaggaactag aagatttata ttctatcatc acagagtcag atattgtagc tataaaagat 12060
atgcttttaa aacctaccgt ttatttggct gttccaatta agtgtccaga gtgtggaaaa 12120
acccatgctc atgtaataag aggcctcaaa gagttctttg agttactata atggcaaata 12180
ttaataagct ttattctgac attgacccag aaatgaaaat ggattggaac aaagatgttt 12240
ccagatcact tggattaaga tcaattaaaa acagtctttt gggaattatt acaacaagaa 12300
aaggttcaag accgtttgac cctgaatttg gatgtgattt atcagaccag ctttttga 12358
<210> 19
<211> 3307
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 19
agagtataat gcttcacgta taaacgtggt ataatgaatc taagtccatc caataacaat 60
tgaatagaga acaatatgag attagaagat cttcaagaag aattgaagaa agatgtgttt 120
atagattcga ctaaattaca gtatgaagca gctaataatg tgatgttata tagtaaatgg 180
cttaataagc attcaagtat taaaaaggaa atgcttagaa ttgacgcaca gaaaaaagtt 240
gctcttaaag ctagattaga ctactactcg ggacgaggag atggtgatga atttagtatg 300
gatcgttacg agaaatcaga aatgaaaaca gttctatcag ctgataagga tgttttaaag 360
gttgatacct cgttacagta ttgggggatt ttattagatt tctgtagcgg agctcttgat 420
gctattaaat cacgtggatt tgctattaag catattcaag acatgcgagc atttgaggct 480
ggaaaataat gagatatagc attgatgatg cttttaatta tgaagaagaa tttgaaacgg 540
aaattcaatt cttaatgaaa aagtataatc ttaagcgtca ggatattcgt atcctggccg 600
atcactcgtg tggtgaagat gtcctttata ttaaaggaaa atttgccgga tatcttgatg 660
aatattttta ttctaaagat atgggcattg atatgcatat gagagttgta taaatagata 720
tataattcag aggagacaat catgtcagat aagatttgtg ttgtctgtaa aactccaatc 780
gattctgcat tggttgttga aacagacaaa ggtcctgtac atcctgggcc ttgttataat 840
tacattaaag aactaccagt ttcagaaagt tcggaagaac aattaaatga aacacaactt 900
ttgctatagt gtgaccttta gtctatagtt ttggcccttc ctttttggtt gggccttttt 960
taatttaaaa gctttcttct acttcatcgt ctgaatcttc taattcagct ctttttcctg 1020
ccaaagcatc tctcacagag atgtcatcag tatcttttaa ttcagtttct ttgactcttt 1080
tcttgtaata agcttcaagt tcttctaaac cttctaatgt ttgacaagag gcaattttac 1140
ccataaattc atcaatagaa gcttcataaa gaaattgttt aaatcctagt aacatctttt 1200
tctccaaagg gccgaagccc ttataaatta actgtttttc taagtattct tagtttgtac 1260
attgataatc cagtagcttt agaagcatct ttcatacatt tatatttaac accatttact 1320
tctataggtt tagcagctgg gttattagct cctgaattat ctggcatgtt atctttaatt 1380
ttctgaatag atttagcaga atgtttcctt ccatacatgc cgttattttt acccgattga 1440
ttgattgaat gtaatctttt agcttcttca gtccatttcg ttgggttcat tcttttagtt 1500
ttactaattt tatttcccca tgtaattgga cgacttttca tgagttttga catatattgt 1560
ttatgttctt ccgtatggtg ttttccgtaa aatggattac cttcgccgga ttgaagttct 1620
gccattttac gacgttccca tgcgtaagat ttattaacgt gtctttcatg agtatttgaa 1680
ttcatcccca tacatataac agctttaatt ataccgtaat ggtttggatg aattttagct 1740
aaaagtttat gggctataaa atgttcttca gccgttagtt ctactaaatt acacttatca 1800
tttgtaccac ccatacatct aggaattata tgatgtgttt cagtgtatcc attaaggcga 1860
gcccgattct gggctctatt aattaaatta tcatatatta atttataatt caaagtttaa 1920
cctctttcat cacataatta aacttttcat cagcataacg ctgaatacga tcaagtccat 1980
gttttaaaag atagtttaaa tgcgagtatt ttttagaaga tgtttttgat ttagaaacta 2040
cgcccgcgtc atctatgagg tcccagactg ttgcgattgt tttagaacca tgcttacgta 2100
atacacgacc gattgtttgt aatacaataa tttttgattt aacgccgtgc gctaaaacaa 2160
catgatgcag atttttaact gaaataccag tagaaaatac accataactc gctactataa 2220
ttattccttt accattttca gctaaggttt tcattacgtt gcgggtttcg gtatcaactt 2280
cccctgatac gtaataaact ttatcgtatt catttttaat taaatcgaaa atagctttac 2340
catgtgatac atgtttaaac atgacaaaag cgttttcatc tttttgcgca agcttaatag 2400
ctaatttagc gatccattta tttcttttac taagccccgt aataattttt atttcttctt 2460
gataagtttt tccctttaat ttagtagtga actcatcggg atagcgaaga aaaatactat 2520
taatttttaa ctcagttact tgtccatctt ccattaattt agaggtcgtt actggcttaa 2580
atatttcacc gaacattcca acatactgca tgatattggc tttgccatca cgtaatgaac 2640
cagacaaacc aaatttaaac atacagttat ttaaacctga tatgatagat gaaatacttt 2700
ttcctgtggc aagatggcat tcatcattca tcatcattcc aaactgtgag aaccattctt 2760
ttggctgttt tactacagtt tgccatgtac caacaacgac tggtgcatca tttttatatt 2820
tatcatcttt tgatgctccg ccaccaattt tctttatcat tgcatgactg aataaacgat 2880
agtcaacaaa gtcatcagcc atctgagttg tcagagcagt tgttggaaca atgataagaa 2940
ttttaccttc ataattttcc aaataatacc gagcgagcaa agcttgaatt aaagatttac 3000
ctgcggatgt tggaagatta agaattctac gacgattaac taatccttcg aacactgcat 3060
ctttttgata ccaatgcggt tcaattcttt tatttcctga atagatttct aatttagaaa 3120
gccattcatc aaaatctttt cttgataatt cttctttttc gttaatttgt gggtcaatcc 3180
aggctttata gccaaagtta tcacagaact ttttaatttg cccaactaag ccgaacggaa 3240
gaaggcgatt ataatctaaa agacggattc gtccatccca gttgccatat ctgaagcgag 3300
gattaaa 3307
<210> 20
<211> 2793
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 20
aacttaaata tgctaagcct ttggcttctg ctgcacgaaa agcagttcgt cactttgtgg 60
taacactgaa gtaattcatt ggagattcac tgccttagtg tgagctaaaa tcgaggagcc 120
gtcgaactgt ctgattaatg atttgcgaat cattatagtt ttaagacccc ggcagtttta 180
cggtgtacct cttgaatgtg aatgatgacg ggtttatggt tatcctggtc gttaaatatc 240
caaaaaccta tgttcccctt gagggcttgc gcaggcaatg ccaataagtc ctgcattttc 300
atttaaaaga gaatttataa tggcaaaaca agctaaagca aagaaagcag ttgaaaagaa 360
agttggtgat tctaaacgcg ctggctacaa gcgtgggtcg aactctcgta tcaatcaaac 420
tgttgagaag atcatgcgcc gagcacgtgc ggttcttcga gatgatgctt ctcgttttgg 480
taagcagaaa gcataagtta aggactcctt cgggagtcct tttttatttt ccaaagattg 540
cacaaagttg tttacagtat ggttcctttg tgatagtatt atcttacaca aacaaaggag 600
aataaaatga aaacgattaa tctgaacgct acagttaaaa ctaaatgctt caatggtaaa 660
tatgatgaaa ctatgtggtt cttaatggca gttgaaggtg atattattga agtagaaaca 720
acagaaggta tgggaacaga tttcaccttt acaattcaag ttcataattt ctttactggt 780
tggatttatg aattgaatac agtaatcgtt ggaaaaattg aacaaaatga attaggtgaa 840
tggtattatg ttacagctcg ccaacgtgcc gaacgcttaa ttgagaagat gaaaaaagtt 900
ggtaaacttg acatgcagca ttggaaagta gtaaaataat tgtttacttt ggtacaggat 960
atgatattat atacctgtac cgcaattaaa catctcggag aataaaatga actacatcaa 1020
ctttgaacgt aaatatgttt ctaacggtat tgcaggttct attgatacta tttgcctttg 1080
gaaacatcaa aatggatcag tatgcgaaat tgaacagtat atgactccta actacgttta 1140
tatgcgattt gaaaatggca ttacggtttc aatcacgaaa gaaggttctt cttttaaaat 1200
cgcattagat gatgattttc gtcaacgtga tttagggact catccttgct ggaatggcgt 1260
taatcgtaag cttctggtta aaacttggat tcgtcatatt ctgagtaata gagctaaacc 1320
tgagcatctt gaagcaatct ttgatgtagt tcttaacgaa tttgatattt aaaataaaat 1380
gaggggcttc ggccccttac tgaggaaaat actatgttta tgactactta ttttgatacc 1440
cgcaaaaatt tctgtgaagt ggttttctct aaggcaccta aagaccttcc tgctcatttg 1500
cagcctacta gtgaatcgat taaaaattac gttaatgcag tctgcccttt agagttccgt 1560
actgtaaatg gacgcgatac tttagctatc actaaactca atcgtgaaat tgacattgac 1620
ccttcaattg cgcgcgaaat taacatttct gatatcggcg gcggtaatgt taaatcacac 1680
ggttttcaga tgagatttta ataaaatgtt taagaaatta atccagaaat tactgggcac 1740
ggaaatggtc gaagttactt atcgtgtgac tgatgtctct ccgctcactg aagaccattt 1800
agagccatat attatgacaa ttaaaatgct taaacatgat ggcggattat ctattgaaga 1860
ccgtttacca agttatggtc attgggctga tattgaaatt ataagtatta aagatgtctg 1920
agttagagat tagaagcaat tttagatggc catcatgtgc attaagtaat ttcgcccaat 1980
ggccttttgt tatggacggt atccaatttg gaggtctcga aggattcctc caaggatgca 2040
aggtgaaaaa tgttgaacaa cagcgtcgta tatttgggtt atccgggctt gccgcccaac 2100
aagctggacg agcttatgct agagctcagg accgtggcac gttgttctgg cttggaactc 2160
cgttttcaag atattccgaa gcatggaaag aattatacac aaatgcatat tttgaagcag 2220
cgatccaaaa caggggcttt cgcgatgcat tacaagcctc gaaaggaaaa gttttgaagc 2280
acagcatggc tagtggtcta acaaaagatg atacaatact aaccgaagct gaatttattg 2340
atgtgttaaa tctattaaga gactctctat gaagcctact attttgactg atattgatgg 2400
agtatgttta agctggcaat caggccttcc ttattttgct cagaaatata atcttccgtt 2460
agaacatatt ttaaaaatga tccaagatga gaaatttatt tctccaggta aactatttaa 2520
ttgtgatgaa gaacttggcg tcaagttaat tgaaaaatac aatcgttcgg attttattcg 2580
ttacttgtct ccatataaag atgccctgtg tgtgattaac aaattaaaag aagattataa 2640
ttttgtagct gttacagcat tgggtgattc tattgacgct ctgttgaatc gtcaatttaa 2700
tttgaatgct ctttttcctg gtgccttctc agaagtaatg atgtgtggtc atgattcttc 2760
aaaagaagag ttattcaaaa aggcaaaaga gaa 2793
<210> 21
<211> 455
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 21
ttactgacat aacatgagga ctttatgatg gatttgcagc ttattactac tgagatggtc 60
gttgaagcat acggtgatac tacagatggg atttctgtat ttaaaggaaa tcgtcgagtt 120
ggatatatca ccgatcttaa gaaagattta gctaagcaag tcaagcggaa aacgaccatt 180
aaagaatatc gaaatcgtcg tcttgagcaa gcccgtgata tgcttcctga tgcggttgag 240
gagatgaaag tctttttaga aaatcagctt gcgaaatatg attgtgatgt gttcattaat 300
cagactcaac ctaatgttca tattaacaac tgtaaatgct atatcatcgt taatcctttg 360
acgggaaaac atcgtcttgg aatcagtaat ccaaatcgta gcgcatcgga tatggcagaa 420
gatgttgagg catgctttaa aatttctaaa tctcc 455
<210> 22
<211> 4455
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 22
aattcagtat aattatattg atgcgatgaa taataaaaat cgtgaggcaa ttgctgctat 60
tgagcgtgaa aatgaaaaac tgcgcaaaga cgcaaagaag gcggatgtgg tggctcataa 120
gccaggattg gttgaaaaac aaatcaacaa ctccttcaac aagttcgcag aagacatcca 180
ggacctttct aaatgattaa attatcagca gtaatattat ctattggtct tctagttggt 240
tgttcgacaa agcctctaga agtaaagaaa gaaacagttc atcctaattg gcctgtacaa 300
ataaagtcat atgacgaagc taaattatct tggcaagtta aagttattga tggtaaagct 360
tgggttggta tgccatttga agattctcag gaatttcgta tttggcttaa tgatgtaaaa 420
cgatatgtac atgaccaaaa aactatgata tgttattatc gtcaagagtt aaaagaggat 480
aaatgtaaat gatttcatgg catcaatttg aacatctcaa aggattgatt tatgaatccg 540
agatggctgc aatgatttat ggacgccaga ttcagcggtt agaatcttta cctccaacta 600
atgatgtttt attagctcaa tcacgtgcta atctcaaaaa tgaatatcaa aataagtggg 660
gtaaagcatc taaagaccta catgattata ttcaatcact ggttgagaaa aaataaatga 720
aaaagattat tttgactatt ggctgtcctg gttctggtaa gagtacctgg gctcgtgaat 780
ttattgctaa gaatcccggg ttttataata tcaatcgtga tgattatcgt caatccatca 840
tgggtcatga agaacgcgat gagtataagt ataccaaaaa gaaagaaggt atcgtaactg 900
gtatgcagtt tgatacagct aaaagtattc tgtacggtgg tgattctatt aagggcgtaa 960
tcatttcaga tactaacttg aatcctgaac gtcgcctagc atgggaaact tttgccaaag 1020
aatacggctg gaaagttgaa cataaagtgt ttgatgttcc ttggactgaa ttggttaaac 1080
gtaactcaaa acgcggaact aaagcagtac caattgatgt tttacgctca atgtataaaa 1140
gcatgcggga atatctcggt cttccagtat ataatgggac tcctggtaaa ccaaaagcag 1200
ttatttttga tgttgatggc acgttagcaa aaatgaatgg tcgtggtcct tatgaccttg 1260
aaaaatgcga taccgatatt attaatccaa tggtcgttga actagctaag atgtacgata 1320
agcaaggata ttacattgta gtcgtttcag gccgtgaaag tggaactaaa gaagacccaa 1380
cgaaatatta tcgtatgacc cgtaaatggg ttgaggacat tgctggcgtt ccattagtta 1440
tgcaatgtca gcgcgaacaa ggcgatactc gtaaagacga tgtagttaaa gaagaaattt 1500
tctggaaaca catcgcaccg cattttgatg tgaaattagc tattgatgac cgaactcaag 1560
tagtagaaat gtggcggcgc atcggtgttg aatgctggca agtcgcttcg ggagattttt 1620
aatggcttgg caccatgaaa ctttgtctat tattgattgg cttgaagaaa attatgtgag 1680
gtaaatatgt ttccgactta ctctaaaatc gtagaagtag tgtttagcca aattatcgct 1740
aataatatgt ttgaaaaact tgataatgca gctgagcttc gaatccatgc tcaagtgact 1800
catgtattga atactttgct tccagaccag gtggattctg ttgccatcac gttgtatcca 1860
ggttccgcgc atatcattgt cgtatttggt cttgatgctg agctagttat tacaggcgat 1920
attcgctttg aatcacagac atcagaattc aaagcaattt aacagtttac tttacggtag 1980
agttgtgata ttatagctct accaaacaaa tgaggaaaac aaaatgctgc taagtgaaaa 2040
accaattact gttaaagaat tccaagaaaa agttaaacta tttgcacagg aattagtaaa 2100
taaggtttct gaacgatttc ctgaaacatc ggttcgtgtt attaccgaaa ctcctcgttc 2160
agtattagta attgtgaatc caggtgatgg cgatcaaata tcgcatctta aactggattt 2220
tgatggatta gttgaagcac aaagggtgta tggcgtacta tgatgaattt aactgatata 2280
attgataatt gtcttgaaaa tgatactggt gatcatagag cgcttgattc tgaaacagca 2340
aagttcatta gaataacttt aatgaatgat actctagtga atagtattca tccttctgtg 2400
tatgatgcta ttattgtgac gaagtatcca gttgagcttc acaaaaagat gactggcgca 2460
gtttttattg ataagaaaaa ccgctttaaa gatgggcaga atataattag ttctgttatt 2520
aaaagtataa ctaaacttcg tcacgaaatt tatcgtgttg aaactgctaa atctgcttat 2580
ctggtgatta tgaaatgaaa gcgagtacag tacttcaaat tgcatattta gtatcgcagg 2640
aatcaaaatg ttgctcctgg aaggtaggag cagtaattga aaagaatgga cgtattattt 2700
ctactgggta taatggttca cccgcagggg gagtgaactg ttgtgattat gctgctgagc 2760
aaggttggtt gttgaataag cctaaacata ctatcattca aggtcataag cctgaatgcg 2820
tatcatttgg ttcaactgat cgttttgtct tggcgaaaga acatcgtagt gctcactcgg 2880
aatggtcatc taaaaatgaa attcatgctg aactaaatgc aattttgttt gctgcacgaa 2940
atagttcttc aattgaaggt gctactatgt atgtaacact ttctccttgc ccagattgtg 3000
caaaagtgat agctcaatct ggaattaaaa agttggttta ttgtgaaaca tacgataaaa 3060
ataaacctgg ctgggatgat attctgcgaa atgcgggtat tgaagtgttt aatgttccta 3120
agaaaaactt gaataagtta aattgggaaa atatcaacga attctgtggt gaataatgaa 3180
atttcgtttg gtacaactca cagcaattag ttcttattct aatgagaata tttcatttgc 3240
tgtagagtat aagaaatatt ttttctctaa atggaagcag tattataagt cagaatgggt 3300
ttgtattgat agaccatata gttggaaatc tgatttagaa aaatgccaaa aattgctttc 3360
cactcttaaa gaacgtggaa caactcatat taaaactgta ataggtaaat aaatgaaact 3420
gacaactgaa cagaaagtag caattcgtga aattttgaaa actaaattgt ccatgggtat 3480
ttcaaacgta gtttttgaaa agtctgatgg tactattcgt actatgaaag gtactcgtga 3540
tgcagacttt atgccaacca tgcaaaccgg taaattgact gaatctactc ggaaagaatc 3600
tactgacatg attccagtat ttgatgttga gcttggtgca tggcgaggtt tttctattga 3660
caaattgatt tctgttaatg gtatgaaagt tgagcatttg cttcaattta ttggtaaata 3720
aatgctttaa gaattatttg ttattattaa ttcatctgtt aacaaaaagg aaaaacgatg 3780
tctgaagtac aacagctacc aattcgtgct gtcggtgaat atgttatttt agtttctgaa 3840
cctgcacaag ccggtgatga agaagttaca gaatcaggac ttattatcgg taaacgtgtt 3900
caaggtgaag ttcctgaatt gtgtgtaatt cactctgtcg gtcctgatgt tcctgaaggt 3960
ttctgcgaag ttggtgattt gacttctctc ccagttggtc aaattcgaaa tgttccgcat 4020
ccttttgtag ctctgggtct taaacagcca aaagaaatta aacaaaaatt tgttacctgt 4080
cactataaag ctattccgtg tctttataag tgatataaat aataatatga attgggtgtc 4140
ggaataataa gttaaccgaa caattctatg tggtagtcta caactgagag atctgtcgaa 4200
agaagatgaa attcagaaga acgtgactac cgagttttaa tctctaacga gaatttttaa 4260
atgattaaac aactacaaca cgctcttgaa ctgcaacgaa acgcatggaa taatggtcac 4320
gaaaactatg gcgcatctat tgatgttgaa gccgaagctc ttgaaatcct gcgttatttc 4380
aaacatctga atcctgctca aactgcatta gctgctgagc ttcaggaaaa agatgaactt 4440
aaatatgcta agcct 4455
<210> 23
<211> 14383
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 23
tataattcat ataaattacc accgcgtggc aaaatttatt catattttgt aaaagcgggt 60
ctttctaaat taactaatag cattaatgaa ttttgaggtg aataatggct aaaaaagaaa 120
tggttgaatt tgatgaagct atccatggcg aagacttggc taaatttatt aaagaagcat 180
ctgatcataa actgaaaatt tctggttata atgaattgat taaagatatt cgaattcgtg 240
ccaaagatga acttggtgtt gatggcaaga tgtttaatcg tctgttagct ttgtatcata 300
aagataatcg tgatgtgttt gaagctgaaa ctgaagaggt agttgaactt tatgacacag 360
ttttctctaa atgatattcg tccggtcgat gagaccggtc tttcagaaaa agaactttca 420
attaagaaag aaaaggatga aattgcaaag cttcttgacc gccaagaaaa tggatttatt 480
attgaaaaaa tggtagaaga gtttggaatg agttatcttg aagctacaac agcattctta 540
gaagaaaatt ctattcctga aactcaattt gctaaattta ttccttcggg tataattgaa 600
aaaattcagt cagaagctat tgacgaaaat cttttacgcc cttctgttgt tcgttgtgaa 660
aaaactaata cattagattt tctattatga ttaaactccg catgcctgct ggtggtgaaa 720
gatatattga tggtaaatca gtttataaat tatacttaat gataaaacaa catatgaatg 780
gaaagtatga tgtaattaag tataattggt gcatgcgggt gtctgatgcc gcttatcaaa 840
agcgaaggga taagtatttt ttccagaagt tatcagaaaa atataaatta aaggaacttg 900
ctttaatctt tataagcaat cttgttgcta accaagatgc ttggattggt gacatctctg 960
acgctgatgc acttgtgttt tatcgtgaat atatcggacg cttaaagcaa attaaattta 1020
agtttgaaga agatattcgc aacatttatt attttagtaa aaaagttgaa gtttctgctt 1080
ttaaagaaat ctttgaatat aatccaaagg ttcaatcaag ttatattttt aaactgcttc 1140
agtcgaatat aatttcgttt gaaacgttta tcttgcttga ttcgttttta aatataattg 1200
ataaacatga tgaacagact gataatttag tctggaataa ttattctata aagttaaagg 1260
cttatagaaa aattttaaat attgattcac agaaagctaa aaatgttttt attgaaactg 1320
tgaaatcttg caagtattaa ttgcttatta taaatagatt ataattatct cactgaccag 1380
ctatgaggtc atacatcgtc atagcaccaa ctgttaatta aattaaaaag gaaataaaaa 1440
tgtttaaacg taaatctact gctgaactcg ctgcacaaat ggctaaactg gctggaaata 1500
aaggtggttt ttcttctgaa gataaaggcg agtggaaact gaaactcgac aatgcgggta 1560
acggtcaagc agtaattcgt tttcttccgt ctaaaaatga tgaacaagca ccattcgcaa 1620
ttcttgtaaa tcacggtttc aagaaaaatg gtaaatggta tatcgaaaac tgttcatcta 1680
cccacggtga ttacgattct tgtccagtat gtcagtacat cagtaaaaat gatttgtata 1740
acactgacaa taaagagtac ggtcttgtta aacgtaaaac ttcttactgg gctaacattc 1800
ttgtagtaaa agacccagct gctccagaaa atgaaggtaa agtatttaaa taccgtttcg 1860
gtaagaaaat ctgggataaa atcaatgcaa tgattgcagt tgatgttgaa atgggtgaaa 1920
ctccagttga tgtaacttgt ccgtgggaag gtgctaactt tgtactgaaa gttaaacaag 1980
tttctggatt tagtaactac gatgaatcta aattcctgaa tcaatctgcg attccaaaca 2040
ttgacgatga atctttccag aaagaactgt tcgaacaaat ggttgacctt tctgaaatga 2100
cttctaaaga taaattcaaa tcatttgaag aacttagcac taagttcagt caagttatgg 2160
gaactgctat tatgggtggt gctgcggcaa cagctgctaa gaaagccgat aaagttgctg 2220
atgatttgga tgcattcaat gttgatgact tcaaaacaaa aactgaagat gattttatga 2280
gctcaagttc tggcagttca tctagtgctg atgacacgga cctagatgat cttttgaatg 2340
acctttaata gattatatta ctaattaatc ggggacccta gaggtcccct tttttatttc 2400
aaaaaatttt ttcacaaaac ggtttacatc cttgtccttc catggtacta tacaactatc 2460
ggcaatactg ctgatgatta aagaggaaaa taatatggct aaagttgata ttgacatcgt 2520
tgattttgaa tatattgaag agattattcg taatcgttat cctgaactta gtatcacaag 2580
cgcgcaagat tctaagtttt ggagtattca aatcgttatt gaaggtcctc ttgaagacct 2640
cacccgcttt atggctaatg aatattgtga tggtatggat tctgaagacg cagaatttta 2700
catgggattg attgaacaat aattatcaag gggttatcaa gcccctatta aaatgaggaa 2760
aatcaaaaat ggaaatcggc aaaaaatatg agttaaatcc acaccgtatt aaatctttca 2820
ttgatattag ttcatcaaat gctaatatgg tcggcatcat tcaagaaaat ggtggttggt 2880
ttgaagttaa atcaatatca agtttagatg gatttgatta tgtaaccgaa atcatttgcg 2940
ccaatggtga aatctataat gatgatggta tgggtgatga ttattttgaa cttagtgaag 3000
aagagtttta ttgttttcgt gagtataaag aaccgacttc tgaagaagat gaaatcgaag 3060
acaaggtttc tggcgtaaca aaaattcact gcattgttga cgaaaacaat gtagatgaaa 3120
tcattgaact tttgcgaaaa actttcaaaa agtagtttac agaagggtag tagtgtgata 3180
ctattaccct atcaactaag gagaataaaa tgagattaca acgtcagagc atcaaagatt 3240
cagaagttag aggtaaatgg tattttaata tcatcggtaa agattctgaa cttgttgaaa 3300
aagctgaaca tcttttacgt gatatgggat gggaagatga atgcgatgga tgtcctcttt 3360
atgaagacgg agaaagcgca ggattctgga tttatcattc tgacgttgaa cagtttaaag 3420
ctgattggaa aattgtgaaa aagtctgttt aaggaaaata atatgatttt tgtatttgaa 3480
tttatgaatg atgaattcga ttatgcaatt tttaacgcat tgcataatcc tgatttaagt 3540
gaatttaatg aaatgttttc tgacgctttg agtatgtcag aagaatactg tggagagtgt 3600
caacgtgttt gtgtgacagt ctttgaaaac aaagaaaaga catatgaaga attattcttt 3660
gatgctaata aagccactga atggtttatt gaaagggggt ttgcgtaatg attaaattgg 3720
tattcgctta ttctccaacc aaaacggtcg aaggctttaa tgaattagca ttcggtttag 3780
gtgatggttt accatgggga cgagttaaaa aggacctcca gaattttaaa gctcgtactg 3840
aaggtacaat tatgattatg ggtgctaaaa cgttccagtc attgtctaca ttacttcctg 3900
gtcgtagcca tattgtagtg tgtgaccttg cgcgtgatta tcctgtaact aaagatggcg 3960
atttagcaca tttctatatt acatgggaac agtatataac ttacatttct ggcggcgaaa 4020
ttcaagtgtc aagccctaac gcaccattcg agactatgct tgatcagaat tccaaagtaa 4080
gtgtaattgg cgggcctgct ctgttatatg ctgcgttacc ttatgcagat gaagtagttg 4140
tttctcgcat cgttaaaagg catcgtgtta attcaacggt tcaattagac gcaagttttc 4200
ttgatgatat aagcaagcgt gaaatggttg aaacgcattg gtataaaata gatgaagtaa 4260
caacccttgc ggaatcagta tataaatgaa acaataccaa gatttaatta aaaacatcct 4320
tgaaaatggt tatgaaaccg atgatcgtac aggcacagga acaattgctt tgttcggtac 4380
taaattgcgt tgggatttaa ccaaaggttt tcctgcagta acaactaaga agctcgcctg 4440
gaaagcttgc attgctgagc tactttggtt cttatcagga agtactaacg taaatgattt 4500
gcgattaatt cagcatgatt cattaattca aggcaaaaca gtctgggatg aaaattacga 4560
aaatcaagca aaagatttag gataccatag cggtgaactt ggtccaattt atggaaaaca 4620
atggcgtgat tttggtggtg tagaccaaat tgtagaagtt attgatcgta ttaaaaaact 4680
accaagtgat aggcgtcaaa ttgtgtcggc gtggaatcca gctgaactta aatatatggc 4740
attaccgcct tgtcatatgt tctatcagtt taatgtgcgt aatggctatt tggatttgca 4800
gtggtatcaa cgctcagtag atgttttctt gggttaattg aggcctgagt ataaggtgac 4860
ttatacttgt aatctatcta aacggggaac ctctctagta gacaatcccg tgctaaattg 4920
taggactgcc ctttaataaa tacttctata ttcaaagagg tatttatgaa aagcggaatt 4980
tatcagatta aaaatacttt aaacaataaa gtatatgtag gaagtgctaa agattttgaa 5040
aagagatgga agaggcattt taaagattta gaaaaaggat gtcattcttc tataaaactt 5100
cagaggtctt ttaacaaaca tggtaatgtg tttgaatgtt ctattttgga agaaattcca 5160
tatgagaaag atttgattat tgaacgagaa aatttttgga ttaaagagct taattctaaa 5220
attaatggat acaatattgc tgatgcaacg tttggtgata catgttctac acatccatta 5280
aaagaagaaa ttattaagaa acgttctaaa actgttaaag ctaagatgct taaacttgga 5340
cctgatggtc ggaaagctct ttacagtaaa cccggaagta aaaatgggcg ttggaatcca 5400
gaaacccata agttttgtaa gtgcggtgtt cgcatacaaa cttctgctta tacttgtagt 5460
aaatgcagaa atcgttcagg tgaaaataat tcattcttta atcataagca ttcagacata 5520
actaaatcta aaatatcaga aaagatgaaa ggtaaaaagc ctagtaatat taaaaagatt 5580
tcatgtgatg gggctatttt tgaatgtgca gtagatgcag ctagacattt taaaatttcg 5640
tctggattag ttacttatcg tgtaaaatct gataaatgga attggttcta cataaatgcc 5700
taacgactat ccctttgggg agtagggtca agtgactcga aacgatagac aacttgcttt 5760
aacaagttgg agatatagtc tgctctgcat ggtgacatgc agctggatta taattccggg 5820
gtaagattaa cgaccttatc tgaacataat gctaccattt aatattgcat catatgctac 5880
gttagttcat attgtagcta agatgtgtaa tcttattcca ggagatttga tattttctgg 5940
tggtaatact catatctata tgaatcacgt agaacaatgt aaagaaattt tgaggcgtga 6000
acctaaagag ctttgtgagt tggtaataag tggtctacct tataaattcc gatatctttc 6060
tactaaagaa caattaaaat atgttcttaa acttagacct aaagatttcg ttcttaacaa 6120
ctatgtatct cacccgccaa ttaaaggaaa gatggcgata taattttaat ttaattgcga 6180
ggatatatga ttttacgatt taaagatact tctggtgtcg ttctttttac acttcctaac 6240
ccaagtgagt tagaagttcc aggaccaaat cagcctattg tcatttatgg caaaaaatat 6300
tatactcata aaatgactcg tgagtatttt gataataaaa tttctacagt taaaacttct 6360
tcagattgtt actatgatat tactgtatta acggaaaaac aatatgaaga atgtagaact 6420
ttagcagtat aaatatgatt cccaacaatc tagagcacat cttttagata taagttttct 6480
gcttattccg gtttgacgca cagcttctgc tattgttgga tattctaccc catctatact 6540
tactcttaga tggggtttct ttttacctct ttgtgagtca gaaattcgtt ttctaacttc 6600
attggtatgt gtctgtccat aatatggatt attgatgcct ttcatattaa gcgcagcgtt 6660
tctttcttgg aactttttgc ttagttctat agcacgatct aacccatagt gttcttctat 6720
agttttacct ttgatatctt taggtctacc atgtttttgc ttaagttctt ctggtgataa 6780
ttttgaatta ttatttttaa ttgcatttga aattttatta aggatttctt gctttcttgg 6840
gtgatgagat aaggtatccc caaacgatgc gtctgctata ttatacccat tttcctttga 6900
gtcatattca tgtatccaat aattttcacg ttcaataatg atagattttt cgtatggaag 6960
ttcttctatg attttacata cgaaagcatc tttcccatgc ttattataag aacgctgcag 7020
ctttattgaa tgatgatttc cattatctaa atctttaaag tgtcgtttcc atcgttcttc 7080
aaaattaatt gcacttccta tatagtgctt attggtttta gtgtttataa tagcatatat 7140
tccagatttc attatattct cctatataaa attatattta tatggggtaa cttactacag 7200
aggacttatg caattaatta atgttatcaa aagtagtggt gtttctcaga gctttgaccc 7260
acaaaaaatt attaaagttt tatcttgggc agctgaggga acatcagtag atccttatga 7320
attatatgaa aatattaaat catatctccg tgatggaatg acaactgatg atattcagac 7380
tattgtcatt aaggccgctg cgaattctat ttcggttgaa gaacctgatt atcaatatgt 7440
agctgcccgc tgtttaatgt ttgctcttcg taagcatgtt tatgggcagt atgaaccacg 7500
ttcatttatt gaccatattt cttactgtgt aaatgaaggt aaatatgacc ctgaattatt 7560
gtcaaaatat tcagcagaag aaattacatt tttagaatca aaaattaagc acgaacggga 7620
tatggaattt acttattccg gggcgatgca attaaaagaa aaatatctag ttaaagataa 7680
aaccactggt caaatttatg aaactccaca gtttgcattt atgactattg gaatggcact 7740
gcatcaagat gaacctgttg atagattaaa acatgttatt cgtttttatg aagcagtatc 7800
tactcgacag atttcattgc caactcctat tatggctggt tgtcgtactc cgactcgaca 7860
gtttagttca tgcgttgtta ttgaggcagg tgattcatta aagtctatca ataaggcttc 7920
cgcttcaatt gttgaatata tctctaaacg cgctggaatt ggtattaacg ttggtatgat 7980
tcgtgccgaa ggttctaaga ttggcatggg tgaagtacgc catactggtg ttattccttt 8040
ttggaaacat tttcagactg ctgttaaatc atgctcacag ggtggaattc gtggcggcgc 8100
tgctactgct tattatccta tttggcattt ggaagttgaa aatcttctcg ttttgaaaaa 8160
taacaaaggc gtagaagaaa accgcatccg tcatatggat tatggtgttc agctgaatga 8220
tttgatgatg gaacgattcg gaaagaacga ttacattact ttgttcagtc cgcatgaaat 8280
gggtggcgag ctttattatt cttattttaa agatcaagac cgtttccgtg aattatacga 8340
agcagcagaa aaagacccta atattcgtaa aaagcgtatt aaagcccgtg aactatttga 8400
attgctcatg actgaacgtt caggaacagc aaggatttat gtacagttca ttgataatac 8460
gaataactat actccgttta ttcgtgaaaa ggcacctatt cgtcagagta acttgtgctg 8520
tgaaattgct attccaacaa atgatgtgaa tagccaacaa acccgtttaa tcaaaattaa 8580
gaagtcggat gtagctaagt tttatgaagc taatcctggc ggtataattc aaagcaaata 8640
aagtacacag accgttaata aataatccat aacaagagga aaagttatgg attattctaa 8700
aatttacaat aaccttattt ctaaagctaa gaacagaaaa ttagattgct ataccgaatc 8760
acaccatatt atacctctgt gtattggtgg ttctgataca aaggaaaacc tggtagattt 8820
gacacccgaa gagcattaca tagctcatca attattagta aagatatatc cagataatca 8880
taaattggta tttgccgcta atatgatgtg tgtttattct gaagataata ttgaacgaaa 8940
gaacaccaat aaacgccatg ggtggcttag aagaaaattg gctatttctg tatctgaaaa 9000
taataaaggc aaaccagctt ggaacaaagg tattcctatg tctccagaag ttaaatctcg 9060
acttcaaaca tcttgggtgt ttacatttcc ggatggtcat gaggaaattc atcgaggtct 9120
taacgaattt tgtaaagagc ataatttaaa tccatctgca atgtcagccg tttgtaaagg 9180
taaacgggcg catcacaaag gatttaagtg taagaaattg gataagattt cagagcttga 9240
taatttagtt ttcgtcagta aacctcatcc aaagggatta aaaccccata acttaattgc 9300
tgtaaaaata aacggtatag aatatcaatc aatacatcga gcatctaaag ctttaggaat 9360
tactagaaaa aaggtagaag aattaaatga atattgatta tgaatttgta gatgaatttt 9420
acgaagatga tgagtatact acaataaaag ttattgaaaa cagaggagaa gtggggcttt 9480
gtactctctc tgcattcgta ctagataatt ttgactggca agaccaagat aaaattaatg 9540
aattagcaga agttcaagtt cgcgctcttg ataatctttt ggattaccaa ggatatccag 9600
ttcctgaagc agaaaaagct aaaaagcgtc gtaaccttgg tgtaggtgtt actaactatg 9660
cagcttggct ggcaagtaat tttgcttctt atgaagatgc taacgattta acacatgaac 9720
tgtttgagag attacaatat ggccttatcc gagcatcaat caagctcgcc aaagaaaaag 9780
gaccttgcga atattattca gacactcgtt gggctcgagg cgaattacct atcgactggt 9840
acaataaaaa gattgaccaa atcgcagctc cgaactacgt ttgtgactgg gcgcagttgc 9900
gggaagacct ggttgaacat ggcatccgta atagcacatt atcagcactt atgccttgtg 9960
agtcatcttc ccaagtttct aacagtacaa acggtatcga gcctccacgt ggaccagtct 10020
ctgttaaaga atcaaaagag ggctccttta atcaagtcgt gcccaatatt gagcataaca 10080
tagacctcta tgattataca tggaaattag ctaagaaagg taataaacct tatcttacgc 10140
aagtagctat tatgctgaaa tgggtatgtc aatcagcttc agcgaataca tattatgacc 10200
cgcagatttt tccaaaagga aaggttccaa tgtcaataat gattgatgac atgttatacg 10260
gatggtatta tggcattaaa aacttctatt atcataatac tcgtgatggt tctggtactg 10320
atgattacga aatagaaact ccaaaagccg atgattgcgc agcgtgtaaa ttgtaatgaa 10380
ttatcaaaaa atctataacg acctaatttc ccgagctcag gctcgggaat ctttatcaga 10440
atataaagag acacatcata taatccctag atgtatggga ggttctgatg ataaggaaaa 10500
tttagttgaa ttaacagcca gagaacattt tatagctcat ttactactat gtaagataaa 10560
tgaaggccat tttgggcttg cctctgcgtt aacgttaatg gcaacagata aagctggcaa 10620
tagaattaat aacagattgt acagcttaca cagaaaatta tttgctaaag ctaattctga 10680
gttctttaag aaatattgga aaaataatcc tcatcctaaa ggaatgttag gcaagcacca 10740
taaaaacgaa actaaacagc atgtatcaaa agtgaataga tacgcatgcc catctataga 10800
aatacataaa ttctcattag atggggattt catagaaacc tttcactcta ttgcggcagc 10860
gtcccggtca gttaatggaa acgggtcaaa tatcaaatat tgtgccgagg gtaaatttca 10920
atatgcttat ggatttagat ggtcatatca acttgatgca aagtttgaca aaataaaacc 10980
aagagattat aaaggaatcc gcggtaagaa atggattaat aatggaagtg aatgcacgct 11040
tataggtaaa gatgatatta taccgccagg ttggaaacac ggcagaattt taaagaggaa 11100
aattaatgtc tacagttttt aatacaaatc cagttgatgt tttaacagaa cctatgttct 11160
tcggttcagg tcttggaatt gcacgttatg atattcaacg acataaggta tttgaagaac 11220
ttattgaacg tcagctctcg tttttctggc ggcctgaaga agtaaactta atgatggatg 11280
ctgcacaatt taacaagctc ccagaacatc aaaaatctat atttatcaat aacttaaaat 11340
accagtcatt gttagactcc atccaggggc gtgcaccatc tgcggtactt atgccattgc 11400
tttcagatcc ttcattagat acatgggttg ctacatggac ttttagtgaa actgttcaca 11460
gtcgttcata tactcatatc atgcgtaact tgttcaatga ccctgctaag gtatttgatg 11520
agattgtatt agacgaagct attatgaaac gtgctgaatc tattggtcgc tattacgatg 11580
atgttcttaa gaagacccgt gaatgggaaa atgctaaaga atttgtagaa ctagctaaag 11640
aatctcctga tgctgatttt cgtttaaatc gagctattaa gcaagaagcc gaagctaaac 11700
gtgctttaat gaagtctctt tacctctgtt tacacgttat taatgcctta gaagctattc 11760
gtttttatgt atcttttgcg taaaatgcgc ctttaaacgg taacgtttat cgaaaactcc 11820
tttaattgct ggaaagtcct ttataggaaa actagcagcc aaggttttgc ttgcaccttt 11880
aattagtata atataaatat gattatactt ttaagaggat gcacaattga actatagaaa 11940
aatttggata gatgctaacg gacctatacc taaagattct gatggaagaa catacgaaat 12000
ccatcataaa gacggtaacc gtgaaaataa tgatttagat aatttgatgt gcctttctat 12060
acaggaacat tatgatatac atttagctca aaaagattac caggcttgtc atgctataaa 12120
gcttagaatg aaatattctc ctgaagaaat ttctgaatta gcttctaaag ccgcaaaatc 12180
tagagaaatc cagattttta atatccctga agtacgagct aaaaatattg cctctattaa 12240
atctaagata gaaaatggta catttcatct tttagacggt gaaatacagc gtaaatctaa 12300
tttaaataga gttgcattag gtatacataa ttttcaacaa gctgagcata ttgcaaaagt 12360
taaagaacgc aatattgcag ctataaaaga aggtactcat gtattttgcg gtggtaaaat 12420
gcagtcagaa actcaatcaa aacgggtaaa tgacggttca catcatttct tgtcagaaga 12480
ccataagaaa agaacatcag caaaaacatt agaaatggtt aagaacggga cccatcctgc 12540
acaaaaagaa atcacatgtg atttctgcgg tcacattggt aaaggtcctg gattttatct 12600
aaaacataat gacagatgta aattaaatcc aaatagaatt caattgaatt gtccatattg 12660
tgataagaaa gatttatcac catcaacata taaacgatgg cacggcgaca attgcaaagc 12720
aaggttcaac gactagtctt cggacgtagg gtcaagcgac tcgaaatggg gagaatccct 12780
ctgggattgt gatatagtct ggtctgcata gtaatatgta gcagttcata agagaacggg 12840
ttgagaatta gcgagctcaa tcgaacataa cggtaccttt aacttccata agaacatgga 12900
aatcatggaa ggtaatgcca agattatgaa gttcattgca cgcgatgaac agcttcacct 12960
taaaggcact caatatatta ttcgtcagct tcaatccggt actgatggcg atgaatgggt 13020
taaaattgct caagagtgtg aacaagaagc agttgatatt ttcatggaag ttaaccgcca 13080
agaaaaagat tgggcagttc atttatttaa agatggtgat gttcctggat taaatacaaa 13140
tagcatgtgg agctttattg attacttaac tgtatctcgt atgaaacagt gtggtcttcc 13200
atgcccaatt accgatgctc cggttaaaca tccatatcct tggattcgtg aatatcttaa 13260
ttctgataat gttcaatccg cgccacaaga agtagaactg tcatcttatc ttgttgcaca 13320
gattgataat gatgttgatg ataaagttat gatgagtttt aaaaaatact tttaaggagt 13380
gggccgcaag gcccatttta ttatgaaaga aattgcaaca gaatattcat ttattaaata 13440
tactgagtta gaattagacg acaacggaag tataaaacaa ttatctattc caaacaagta 13500
taacgtaatt tatgctattg ctataaatga tgagcttgtt tatattggaa aaactaaaaa 13560
tttacgtaaa agaataaatt attatagaac tgctattaac cgtaaagaca aaacgtctga 13620
ttctactaaa tctgcattaa ttcatgctgc gctaaaggaa ggaagcaaag ttgaatttta 13680
cgcccgccaa tgttttaatc tttctatgac aaatgagtta ggtacaatga caatcgcaac 13740
gattgatcta gaggagccac tattcattaa gctgtttaac ccgccttgga atattcaaca 13800
caagaaaaaa tgatgcttcc acatggagtg tggtactata ttcaaaacac aaaagaggat 13860
acacaatgca agaacttttt aacaatttaa tggaactatg taaggactca cagcgtaagt 13920
ttttttactc ggatgatgta agtgcatctg gaagaactta cagaattttc tcatataatt 13980
acgcatctta ttctgattgg ttacttccag acgcattaga atgtcgtgga attatgtttg 14040
aaatggatgg agaaaaacca gtaagaattg cttctcgtcc tatggaaaag ttttttaact 14100
tgaatgaaaa tccattcacg atgaatatcg atttaaatga tgttgattac attctaacaa 14160
aagaagatgg gtctttggta tcaacttatt tagatggtga tgaaattctg ttcaaatcaa 14220
agggttcaat caaatccgaa caggctttaa tggctaatgg aattttgatg aatattaatc 14280
atcaccagtt gcgcgacaga cttaaagaat tagctgaaga tggatttact gctaacttcg 14340
aattcgtcgc tccaactaat agaatcgttc ttgcttatca aga 14383
<210> 24
<211> 28630
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 24
gataataatg aaggaaatat tcattgttat aactgtaact atcatgcacc aatcggaata 60
tatttaaagg agtttgaacc tgatttatat cgtgagtata tctttgaaat aagaaaagaa 120
aaaggtaaaa gtcgtccagt agaaaaacct aaagaacttc ctaaacaacc tgagaagaaa 180
ataattaaat ctcttccgtc atgtgttaga ttagataaac tggcggaaga ccatccaatt 240
ataaaatatg taaaagctcg ttgtattcca aaggataaat ggaaatatct ttggtttaca 300
accgaatggc ctaaattggt taatagcata gcaccgggaa catataaaaa ggaaatttct 360
gagcctcgtc ttgttattcc aatttataat gctaatggaa aagctgagtc gtttcaagga 420
cgtgcattaa agaaagatgc tcctcaaaaa tatatcacca tcaaagctta tcctgaagca 480
acaaaaatct atggagtcga acgagttaaa gatggtgatg tatatgttct agaaggacct 540
atagattcac tttttattga aaatggtata gctattacgg gtggtcaatt agacctagaa 600
gttgttccat ttaaagatag acgagtgtgg gttttagata atgaacctcg tcaccctgac 660
actattaaac gaatgactaa attagttgat gcaggagaaa gggttatgtt ttgggataaa 720
tctccctgga aatcaaaaga tgttaatgat atgattagaa aggaaggtgc aacccctgaa 780
caaattatgg aatatatgaa aaataatatt gcccaggggt taatggctaa aatgcggcta 840
tctaaatatg ctaagattta aattaaccca actaaagcaa atgctaaatc tacgaatgta 900
tcaagagtaa ttactggaat attaacacca tgagcaatag caactggcga taaaacaaaa 960
ttccaaagta aaattcctat catagcagaa atagtaaaag ctatacgttt cttattacct 1020
tttatggcat taacaagtgc cattaatttt tgtaccatat gtcctccttt aaattaatat 1080
ttatcataaa tttgtttact ttctcagctt gttatggtat tataaaataa attgttgagg 1140
atgatataat gattaataaa attgtgcatg aaatggcttt aaacggagat tcatataaaa 1200
tatctgccgt agttgaaaat ttcatactta ataaagtaaa agaatatttc actgattgtt 1260
cagttagtta tcaagaaaaa atggttttaa ccgatgatac tgaaaaatca aataatttgt 1320
tttgctctaa ttttataact aagaagcgta ctagaagatt tgatattgtt atttctcgca 1380
acggtaaaaa gcatataatt gaaattaaac atcaagttgg tggaggtaca gctattgatt 1440
cggttggaat atatttagaa gataaagaga aattaaaaga atacacaaaa actgaaaacc 1500
ccgtgtcatt gatgatatta gattttttgc catgcggata ttatccacgt aataaatgga 1560
caaaaagaga atcatttact gataatccaa ctatccaagc aaggtttaat gaatatgcta 1620
aatcacaaaa cgtgttagta ttactatcaa atacatatga tgaagaatta tataattcgt 1680
tttttgctgc aataaatgag agaatataat gctaggagct atcgcgtata caggtaataa 1740
acaatcatta ttacctgaac ttaagcctca ctttccaaaa tatgacagat tcgtggattt 1800
attttgtgga ggtttatcag tgtctttgaa cgtcaatggt cctgtattgg ctaatgatat 1860
tcaagaacca attattgaaa tgtataagcg tcttattaat gtatcatggg atgacgtttt 1920
aaaagtaata aagcaataca aattatcaaa aacatcaaaa gaagagtttt tgaaattacg 1980
tgaagattat aataaaacta gagatcctct tttactttat gttcttcatt ttcatggatt 2040
tagtaatatg attcgtataa acgataaagg aaattttact actccgtttg gaaaaagaac 2100
tataaacaaa aatagtgaaa aacgctttaa tcactttaag caaaattgtg ataaaataat 2160
ctttagttca ttgcatttta aagatgtcaa aattctagac ggcgattttg tatatgtaga 2220
tcctccgtat ctcataacag ttgctgatta taataaattt tggtcagaag aagaagaaaa 2280
agacctttta aatcttttag attctttaaa tgacagagga ataaaatttg ggctgtcgaa 2340
tgttttagag catcacggaa aggaaaacac tcttcttaaa gaatggtcta aaaaatataa 2400
tgttaagcat cttaataaaa aatacgtctt taacatatat cattccaaag aaaagaatgg 2460
aactgatgaa gtatatattt ttaattaatt gcttacacac tcaaatgata taattattta 2520
acttattaat gaattgaaag gatatatgtg aattaccaaa aaatttactc ggctttaatt 2580
acaaaagcta aatgccggca tcttgatgga tataaagaac gccatcatat aattcctaga 2640
tgtatgggag gagcagatga caaaaacaat cttgttgagt taactgcgcg tgagcatttt 2700
atagctcata gattattaac taaaatatat ccagatgtga gaggattgca ttatgctgta 2760
aatttaatgc gatataataa aggtgttaaa ttaacaagta gattaataga aacccttaaa 2820
atccaaaact ctgttctttt ctcgggtgaa aataatccta gatatggcaa gccgtcatgg 2880
attaaaggca aaaagactcc agaagaaact aaagccaaaa tgcgtctagc tcataaaggt 2940
aaaattatat ccgatgaagc caaggctaat atgagtaaag cccgaaaagg aagatttagc 3000
ggtaaaaatt cgcctcgata tggtttacca aatcctaggc gaggggaaat atggaatagt 3060
tatgatgcgc tttatgaatt atgggtttat aataatagac ctaagcgcac aaaatttaat 3120
aaaatagctg tcaaggcagg ttatcctaat atctgctata gacatatgat agaaaacttc 3180
ataagaaagg aaaaataaca tgccacattt caacgaatgt agtcaactga ttgaaggcgc 3240
ggataaagct caaaatgaat actgggatat tcttggtgat gaaaaagacc cgctgcaggt 3300
aatgcttgac atgcagaaat ctctgcagat tcgtttagca aatgaccgcg aatactgcta 3360
tcatccagat aaattagaaa ctgccggtga tgttgtttct tggatgcgtg aacaaaaaga 3420
ctgtattgat gatgaattcc gtgaacttct gacttctctt ggtgaaatgt cacgtggtga 3480
aaaagatgca tcggcagttt ggaaaaaatg gaaagcacgt tatattgaag cgcaagaaaa 3540
acgcattgat gaaatgtcac cagaagatca gctcgaaatt aaatttgagc ttgtggatat 3600
atttcatttc gtattaaata tgtttgctgg ccttggaatg tcagctgaag aaatctttaa 3660
actttattat ctgaaaaatg ctgaaaattt cgctcgtcaa gaccgaggtt attgatggct 3720
cgtttaaaat aaacgccaac tcaagaaagc ccgcaagaaa cgtattgacc agctatttaa 3780
agattatgac aaggagctca catatgagct cttatctaat cagcttcgta tggttgattg 3840
ggttgcagaa gaaggccctg acgaaatttt tgtaagtgaa gaagccttaa aattaattat 3900
agagcattca aaatgaaaat atccaaagaa gaatttatta gacgtcaaaa agctttaatt 3960
aatttacatg agtggtatgc ttatcaactt aaagtagata gctctaacat aaatgctgta 4020
atggctttat ataaacaaat tcaagatgag catgaattcc tggcacaagt tttcattgaa 4080
gattgatata aatacatctg taattaaaca ataaaggagt ttattatggg tggtttcgtt 4140
aacatcaaga cctttactca tccagcgggt gaaggcaaag aagttaaagg tatggaagtt 4200
tctgtagcat ttgatgtata ttcaaatgaa caccgtattg cagattctca ttatcaaatc 4260
tttccgtcag aaaaagcagc ttattctgat gtagtttccg atgcagcaac ttggaaaact 4320
aagaatgctg caatgtttac gcctacaaca ataggcggtt aataattcaa ggactccttc 4380
gggagtcctt tttttcattt tatggtttac tttccaaaat gagtgtggta taatagaatt 4440
atcttataga ggagagcact atgttaaatc gttggattaa accaaatgaa gaccttcaga 4500
aggttcttga taaagctatc tctgataaat ggggtatgaa aagctgggat tgtgatgtcg 4560
tcacgcattc attcatgatg catgcagatg gttcagtcga gttcaatgct gaaatgcgat 4620
atactgactg gggtggattt caaagagtcg aatttcaaag aggctttttg taatgtttat 4680
ctttaattgg tttaaaagtt tctttacgga ttttttctct acaactcccg gagaaggtgt 4740
agttcctatt tcaaatgact accttccttt aactgtagtt gagtatgttt atatgggaga 4800
tggaacagta gaagcagtta ctatgactta tgaagaagcc caagaatatt ataaaaatcc 4860
ttggcgctgg tcaacaccta ctacatcatc taatacgcag aatacacagt ctagttctga 4920
ttcatatgat actaatgttc ctgttcatgt atggacgggc gattcatgcg gaagttcttg 4980
tgattctggt tgttcatcta catcttgtga ttgaggaaaa ttatggaagc gattttattt 5040
gaaatgtata ttagcagtaa tagcatgtcg tttgctaaag atgttccaat tactgtagcc 5100
gtagtgattg ataagggtta ttgcaaccct atgtatctcg tagaaaattt cgtttcaatg 5160
ccagttccag aagatgttga aataaaactt aaaaagatcg gaattattga aactgtgcca 5220
aatagtccgt ttagagcaat tgaagcattt actaaatccg aatacattaa tgttagcgca 5280
gaacaatata atggtaatcc tttatctttt tattcgtacg attcagtata tgactggaaa 5340
ataaatgaag gaaataaatt tataattgcg agtgaagatg ctttatcata ctttatttat 5400
tatgtatgga ataatttaaa tccaaaattg ctaaaaattc atgaatttga cgatgctcct 5460
actattgttt taggtaaaac aaatgaaagt tctgaagaaa atgcttgaat ggttcaatag 5520
accaaactca atgtatattg atgatggctg ggttgaacaa gcaaataaag aaatgcagaa 5580
cgaatcagaa gaatggatga aatcaatgat tagtgctgag aaagaaaaga aattagaacg 5640
ctcagcgctt aaattgatga gagatatcta tggggataaa tcatgaacag agatatgacg 5700
ctagaagagg ccaaggctaa agcaaatgaa gcactggatt tgcttcttaa aattggtagt 5760
aaaatgatgg aagaaaatga gaaatacatt caggaaaaca aaattcctga cggcccatta 5820
gtaggcaaga ggaaatcaca tgattgaagt agcaaaacat tattcaatag aatttatgtc 5880
taaagaaggt aaatcagtaa atacacttga taaaaagtgc tcattaatta ttcctttagc 5940
agaaaatccg gatattttaa ttaaagatat aaaagaaaga aaatatccag aaaatgttat 6000
tctaattata aagcatactg aagatatttt gcagaataca gattcaccat tttcttcttc 6060
tgaagcttta actattaaag gctataaaag agctcatgaa tatggtcttt ttgacatgtt 6120
tgaagatgat aaggttaaat tagcgagtca accttctaaa agtaaaacat tcattattga 6180
agatattaaa gatataaatg catttgttaa gatggtctgg gctcattttg atgttggact 6240
acgttggaga atgtccgaag aagaaagaaa gattattgaa gctaatcgtc aatttggttt 6300
ttatcgctag gaattagtat ggatttattt gagatgttag aagataatca ttctacgaat 6360
atccagaatg attccagtga ttataagaaa gaataccgta tagtattaca gaattatgga 6420
attgaagccc cagatgctct tctagaagaa ctagcttcat accatcttga ccctccgcct 6480
tgggctccct gggcaaaata attcaaaaag ttgtttactt tcctttctaa cgatgatatg 6540
atagcttctg aagtatatgg aggctatcat gattattaat cttgcagatg ttgaacagtt 6600
atctataaaa gctgaaagcg ttgattttca atatgatatg tataaaaaaa gtctgtgaaa 6660
aatttactga ctttgagcag tctgttcttt ggcaatgtat ggaagccaaa aagaatgaag 6720
ctcttcatcg gcagttgaat aaaatcatta aaaagcattt aactaaatca ccttatcagt 6780
tatatcgtgg tatatcaaaa tcaacagaag aacttattaa agatttacaa gttggagaag 6840
tgttttcaac gaacagggta gattcattta ctactagttt actcatagca tgttcttttt 6900
cttatgctga atattttact aaaataatat tccgcttaaa aactgataaa gcttttaatt 6960
attctgacca tatcagcgat attatacttt cttctcctaa tactgagttt aagtatacat 7020
atgaagatac tgatgggcta gattcagagc gtactgataa cttaatgatg attgtgcgtg 7080
aacaagaatg gatgattcca attggaaagt atagaataac ttctatttca aaagaaaaat 7140
tacacgattc atttggaaca tttaaagttt atgatattga ggtagttgaa tgaaataccc 7200
agtaatgcaa ctaaaagatt ttaaaataaa atcaatggat gcatcggtgc gtgcttctat 7260
tcgtgaagaa ttactttctg aagggtttaa tttatctgaa attgaacttt taattcattg 7320
tattactaat aagccagatg accatacttg gttaaatgaa ataatcaaat ctcgtttggt 7380
tccaaacgat aaacctcttt ggagaggtgt tccagctgag actaagcaag tattaaatca 7440
aggaattgat attattacat ttgataaagt cgtatcagct tcatatgata aaaatatagc 7500
tctacatttt gcttccggtt tagagtataa cacacaagtt atttttgaat tcaaagctcc 7560
tatggtattc aatttccagg agtatgctat aaaagctcta cgctgtaaag aatacaatca 7620
aaactttaag tttccggata gccatcgtta tcgtaatatg gaattagttt cagatgaaca 7680
agaagtaatg ataccagctg gaagtgtatt tagaattgca gatagatatg agtacaaaaa 7740
gtattcaaca tacactatct atactcttga ttttgaagga tttaatctat aatggaagga 7800
cttagattca ttataccatg aaagttttaa agcatttttc ataaagttgt ttacaagtta 7860
aagtaaaaat gttatagtat aagtaattaa ccgtccgtaa gatgtgagaa aaatatgaag 7920
ctgtctaata atcaaattcg taaaattaaa cgtcgtctag agcatactca ggcatctgca 7980
aaaagacgtt ctaaagattt taacttagac ttcaattaca ttaagaacat tttagaccaa 8040
aaagtttgcg cttactcggg agaacctttt gataatcgta ttgaaggaga gaaattatca 8100
ttagaacgtt ttgataataa cgttggatac attaaaggga atgttattgc agtaaagaaa 8160
aagtataata catttcgttc tgattatact ttagaagagt tgattgaaaa gcgtgattta 8220
tttgctttgc gaattggtcg ttcatctgcg aaaaaagttc ataaactaaa tttagatgaa 8280
aagaaatggg ctaaaatcaa aaagacttat aatcaaatta aagctataca gaaaaaacgt 8340
gaaaaccgaa ttgaacacat ttctcagctt tctaaatcaa aacaaacttc tgacgttaag 8400
ctaacgatta tagcactcaa agctcgtatt gatggttctc gtatagcaga aggcgctgaa 8460
gttgttaaat tgaacgttct tcttaaaggc tcggattgga aaactgtgaa aaagttgtca 8520
gaagcagaaa tgcaatatga tatgtgtgat aaaattattc aaggtgtaga gcggtatcaa 8580
aacttgtctt ttattgataa acttaaactg aaaagaggat acccgctaaa ttgttcaatt 8640
tttaaactta tccgaggata atatgtttta tgtatatgcg atagtttacc gagacaaaga 8700
cggatttacg gcgccagttc ctcttgatga acatcgtcct gctgtatttt ttgaaaggga 8760
gattgctgat aaagtattta ctactcttaa agagcagtat cgactagctt taggtatggg 8820
aattccgaga ttagttgaga ctccacgcaa gttttggttt aataaaatag aagttaaaca 8880
tgttaagcct gacgtagaca cacaaagatt atatcagcga attttagata ctgggcgtat 8940
tgttagtatt ccaattgcag ggactttccg atgacatttg atgatttgac cgaaggccag 9000
aaaaatgcct ttaacatcgt tatgagggct atcaaagaaa agaaacatca tgtaactatt 9060
aatggacctg ctggtaccgg taagactact cttactaagt tcatcattga agctttaata 9120
tctacgggtg aaactggtat tattttagca gctcctacac atgcagctaa aaagattctt 9180
tcaaaactat cagggaaaga agcgagtact attcatagta ttcttaaaat taacccagta 9240
acatatgaag aaaatgtcct ctttgagcag aaggaagtac cagatttagc taaatgcagg 9300
gtattaatct gcgatgaagt gtcaatgtat gatagaaagc tatttaaaat tctgctttca 9360
actatcccgc catggtgtac tataattgga ataggcgata ataagcaaat tagacctgtt 9420
gacccaggag aaaatactgc ttatatcagt ccattcttta cacacaaaga tttttatcag 9480
tgtgaactta ctgaagttaa acgcagtaat gctcctatta ttgatgtagc tactgatgtt 9540
cgtaacggta agtggattta tgataaaatt gttgacggtc atggagtacg tggatttact 9600
ggtgataccg ctttacgcga ttttatggta aattattttt caatcgtcaa atctttagat 9660
gatttgtttg aaaatcgtgt aatggcattt acgaataaat ctgttgataa gttaaatagc 9720
attattcgta aaaagatttt tgaaactgat aaagatttta ttgtcggtga aattattgta 9780
atgcaggaac cattaattaa aacatataaa attgatggaa agcctgtgtc agaaattatt 9840
tttaataacg gacaattagt tcgtattata gaagcagagt atacatcaac atttgttaaa 9900
gctcgtggtg tttctggaga atatctaatt cgtcattggg atttaacagt agaaacttac 9960
ggcgatgatg aatattatcg tgaaaagatt aaaataattt catctgatga agagctgtat 10020
aagtttaact tatttttagg taaaactgca gaaacttaca aaaattggaa taaaggtgga 10080
aaagctccgt ggagtgattt ttgggatgct aaatcacagt ttagtaaagt gaaagcactt 10140
cctgcatcaa cattccataa agctcagggt atgtctgtag accgtgcttt catctatacg 10200
ccttgcattc attatgcaga cgctgaattg gcccaacaac ttctttatgt tggtgtcacc 10260
cgtggtcgct atgatgtatt ttatgtatga ttaaatttga ggaagctatt cgtggaaata 10320
actaaagaac agttttatct tcttcaggat aaagttagcg aaatttatga aattgcttat 10380
ggtaaaaatc gtaaaactgt aaaaattgaa tctagtaagt tgatgcttca attagaagaa 10440
attgaacgag atttaattgc gttagaattc ttttgcggtg aagtgaaaac tgttacaatt 10500
aatgattatg ttttaggcga aattagctat ctttatgagg cgattattaa tgattgagtt 10560
gagttggtac cagtttaaat ctcttatggc aaatgttaaa gctgtcattg aggaaaatcc 10620
aggacctgat aatgttacta ttcgcgaaaa agcttcaaag atagtataca gtcttgaaga 10680
gatacaaaaa gatattgaat ctatagcaaa atttattgat gagcccatta ataaagttta 10740
tatccaagat tatactgtag gtcaaattcg cgatttagcg aggaaaattt aatgtttgat 10800
tttattatag attttgaaac aatgggaagc ggtgaaaagg cagctgttat tgatttggct 10860
gttattgcct ttgaccctaa tccagaagta gttgaaacat ttgatgaatt agtttcgcgc 10920
ggcattaaaa tcaagtttga tttaaaaagc caaaaaggac atcgtctttt tactaaaagc 10980
actatcgaat ggtggaaaaa tcaatctcct gaagctcgaa aaaatattgc accatcagat 11040
gaagatgtaa gcactatcga cggtattgcg aaatttaacg attacatcaa tgcacataat 11100
atcgatcctt ggaaatctca aggctggtgc cgtggaatgt cgtttgattt tccaatttta 11160
gtcgatctca ttcgcgatat tcaacgtctt aacggcgttt ccgagaatga gcttgataca 11220
tttaagttag aaccgtgtaa attttggaat cagcgtgata ttcgtaccag aattgaagca 11280
cttctgcttg ttcgtgatat gaccacatgt cctcttccaa agggaacttt agatggattc 11340
gttgcgcata attctattca tgactgtgcg aaagacatcc tgatgatgaa gtatgctttg 11400
cgatacgcta tgggtcttga agatgctcca tcagaggaag agtgcgatcc tctgtctctt 11460
ccaacaaaac gataaaaaat tgtttacttc ctcggttagt tgtggtatta taacatcata 11520
gctactgagg ataataaaat gaaaatttat cgtgttgaat catcgtttag tattcttaat 11580
tatgaagatg ctataacaat acgtcgaaat ctttgtgttc aaataacgcc atacaggagt 11640
ataatagatt catggagcga agagtggcta ttacacgtag gttatgacag acctaatttt 11700
atgcatcata gcgataataa taaaagaatt cctttaccac acgaagataa actattagtt 11760
aaaaacgcta atatagtaat taatactaag ttcaagaaag attatgttgg agtagaatat 11820
catattccag ggtggtttat aggtctttat cattttgctt tcgctagtga atatgatatg 11880
atgagatggt tcacacgaga agagcgggaa gaattatctt ctaaaggatt ttatctcgct 11940
gtatacgaag ttcctgaaga tgaagttatc attggtgggc accaagtaat gttccgcaaa 12000
tcgcatgctg aactcgtaga ttttattgaa atgagataat tatgaaattt aattataatc 12060
ctgaatacac accgaatccg gtagctaaac tgattgattt tgatgttgta agcacttatg 12120
tatgccctgt taaaccactg gaaattaagg aacctactat gactaccgct attgaaatcg 12180
gcaaaaccta caaactggtt gaacctaaaa ttaaaactaa tgccttgatt tctggtcata 12240
aaactctgac tgatgttttt ggcgaaggcg aatttattgt tgaagaattt gccaaaagtg 12300
agtggtttga caaatcttac gtcatccacg gtcgccggtt agataataac aaaataaaga 12360
aaaacctggt ttatgaagat gagttcatcc tgttccaaga agttgaagaa caagacccta 12420
cagacctgtt gtgtgctgct gtgtctatcc gtcgtccttt tgataatcct atctgtggtt 12480
gggtaacaga ccagtgggta gaagatggtg ttgaacttct gaacgttgtt catgcaggtg 12540
attttagcgt agtacctcgt agtgcggtgg tagctatttt gaattaatag tttacaaact 12600
cttgggacca gagtataatg gtcctgtgga gtataaaatc tttttaacaa gtgagagata 12660
actatgatta ttaatattgg tgaaattgct cgtgtatctg ataaatcccg ctctaaagca 12720
gcaggaaaat tggtcgaaat tgtaagcatt cagcttaaac acggcgttaa agatgaagat 12780
tctgaagtaa aagtgcgtat cattcctaaa gatggaaagt ctaaacctca gtttggttat 12840
gttcgcgcga aatttcttga atctgcgttt ttgaaagctg ttcccgctaa aggaattgaa 12900
acgattgata cttcgcatgt aggtgtagac tttaagtgga aactcggtca agctattaag 12960
ttcattgctc cttatgaatt cgaatttact gaagatgagg aaggggttgt tcaaaaacgc 13020
cgtactcgtg ctatgtgcgc atacattact gatcaatggg tagaagatgg tgttaagtta 13080
tacaacgcgg tatttttagg aacatacaaa gtcattcctg aaagttggat taaacactac 13140
agcaaagctc gctatgcata aagtttaaaa ttttttcata aaactatata catcagtagt 13200
tgattatggt actatatcaa tatcaactac tgatacagaa aacaacttgg agaataaaat 13260
ggaaattcgc taaaggtgct gatactcttc tgaaacgcat cgctccaatg tttaattaat 13320
gaggaaattg taatgaaacg taaaattgtt cagaattgca ctaatgatga atttgaagat 13380
gtattatttg atccaaattt ggtagtagtt caaaaggaac atactagcaa gtttattcac 13440
ttgacttctg tttatgtgta tgagaaagtc ggtgataaac aaccaattta tggtgtattt 13500
cgtgaaatta ctgaaaatgg cacaacttat tggaaggaaa tttattaatg gctattaaat 13560
ttgaagttaa taaatggtat caattcaaaa ataaacaagc tcaagaaaaa tttattaaat 13620
atcatactga aaacggaatt tatgcacgac gtttaggtat ggaacctttt aaagttatag 13680
atattgacta tcttggtcgt cctactaaaa ttgtgacatc tactggaaga ttggcattat 13740
cctccggtaa agatattttg gatgaagatt ttatttggct ttctactagc gaagctgaat 13800
tctttgatga agttgaaaat ccataccagg cagctgaaga gcaagagcag gaagagaaag 13860
agcaagaaca aatagaagat ttcacagaat ttcctgtcat gaaagttact attgaaaata 13920
atgaacaggc atggtccttg tatcaaatgc tgaaagcaca ctttaaggaa taattatgcc 13980
aatgtatgat tataaatgcc aatccgaaga ctgtgcaaaa gaatacgaaa aaatcaagaa 14040
aatttctgaa agggatactg atgtatgtcc tgattgtcat cggattgcta ttcggttagt 14100
ttccgctcct aagcatgtga acggtggatt ttacgactta cttaaagggt aattatgaaa 14160
tatgttaatc gttctatcgc agcattagta ttagcagtgt ctttagtagg atgtactgat 14220
gctgataatg caaccaaagt tttgtcttca agtggtttta ctaatattga aatcactgga 14280
tataactggt tcggttgctc tgaaaatgat ttccaacaca ctggatttcg tgctgttgga 14340
cctactgggc agaaagtaga aggaacagta tgttctggtc tattcttcaa ggattcgact 14400
atccgtttta aataaaaggc cttcgggcct ttagctttat gattaccgga gtataatatt 14460
cccgaaacca aacgaggata agtgatgatt aagaatgaaa ttaaaattct gagcgatatt 14520
gaacatatca aaaagcgtag cggcatgtac attggctctt ctgctaatga aatgcatgag 14580
cgctttctgt ttggtaaatg ggaaagtgtt cagtatgtac ctggtcttgt taagcttatt 14640
gatgaaatta tcgataactc agtagatgaa ggtattcgta ctaagtttaa attcgcaaat 14700
aaaattaatg ttactattaa aaacaatcaa gtaacagttg aagataacgg tcgtggtatt 14760
ccacaagcga tggttaaaac acctactggt gaagaaattc ctggtccagt tgctgcatgg 14820
actattccaa aagcaggtgg taactttggt gatgataaag aacgcgtcac cggtggtatg 14880
aacggtgttg gttctagttt gacaaacatt ttttctgtga tgtttgttgg tgaaactggc 14940
gatggtcaaa ataatattgt agttcgttgt tcaaatggca tggaaaataa atcatgggaa 15000
gatattcctg gaaaatggaa aggaacccgt gttactttca ttcctgattt tatgtcattt 15060
gaaactaatg agctgtccca agtttatctt gacattacac tagatcgtct ccagacactt 15120
gctgttgttt atcctgatat tcaatttacc tttaatggta aaaaggttca gggcaatttt 15180
aagaaatatg cacgacagta tgatgaacat gctattgttc aagaacaaga aaattgttct 15240
attgcggttg gtcgttcacc tgatggtttt cgtcagttga cgtacgtcaa taacattcat 15300
actaagaatg gtggccatca cattgactgt gttatggatg atatttgtga agaccttatt 15360
ccacaaatca aacgtaagtt caaaattgat gtaactaaag cgcgtgttaa agaatgtttg 15420
actatcgtta tgtttgttcg tgatatgaaa aacatgcgat ttgattctca aactaaagaa 15480
cgacttactt ctccttttgg tgaaatccgt agtcatattc agcttgatgc taaaaagatt 15540
tcacgcgcta ttctaaataa tgaagcaatt ctgatgccga ttattgaagc tgctttggct 15600
cgtaaattgg cggcagaaaa agcagcagaa acaaaggcag ctaaaaaggc ttctaaagct 15660
aaggttcata aacatattaa agcgaacctt tgcggtaaag atgctgacac tacattattc 15720
ttaactgagg gtgattcggc tatcggatat cttattgatg ttcgtgataa agaacttcac 15780
ggcggttatc cattgcgtgg taaagttctt aatagctggg gtatgtcata tgctgatatg 15840
cttaaaaaca aagaactatt tgatatttgc gcaatcactg gattagttct tggtgaaaag 15900
gcgtttgaag aaaaagaaga tggcgagtgg tttactttcg aactaaatgg cgatacaatt 15960
atcgtaaatg aaaatgatga agtacagatt aatggtaaat ggataacagt aggtgaatta 16020
cgaaaaaatc tataatgact taataatgcg gggtaaaacc cgcgtttcta aatttaaggg 16080
tgaaattcat catatccttc caagatcaat gggaggttct gatgataaag aaaatttggt 16140
gaaactgact tttcgtgaac actttttagc acattttcta ctatataaaa ttcatcgtaa 16200
tcgtgaaatg gcatatgcga tgaatagaat gttaaacact gaaaaatatt tacgttctag 16260
taaattatat gaaattgcta gaatttacca tcaaagagca gtatctgaat ggtcaaaaaa 16320
ctttatgaaa gataaagttt taatgagaag tattaaatcg ggtaaatgcg ccttattaat 16380
taaaggatca tttaacccaa aggaatggtg cggtgttaat aaaggtgtta agcttcctgg 16440
aattaaaggc atgacatgct ttaaaaatga aaaaggcgaa gtttttcgtc ttcatgttaa 16500
tgatccacgc attaaagctg aaaaattagt tggtattgga aatactgttg ctgctactgc 16560
aaaagcagct gaacttgaaa aagcgaaacc atggtataat aaatcagcga caaatccaga 16620
ggctgtaaaa ttaataccaa atttatatga atggtacgtc acgaaatatg accccgatca 16680
ttataaacga acgggagttg ctaaatggaa atcagttaat aatataactg tgaattcaaa 16740
attattcggc cgagcattta atgaatttaa acgcggctgg attcctgatg aaaagttcta 16800
cgaggtgtat aatgaaattt gtaaaaattg attcttctag cattgatatg aaaaaatata 16860
aatcgcagaa caatgtccgt cgttctatta aatcctcttc aatgaactat gcgaatgtcg 16920
ctattatgac agacgcagat cacgatggat agccttcggg ctatccattg aaatacctca 16980
taattaagag attattggat taggttctat ttatccttct ctgctcggat tttttagtaa 17040
ttggccagaa ctgtttgaac aaggaagaat tcgctttgtc aaaactcctg taatcatcgc 17100
tcaggtcggt aaaaaacaag aatggtttta tacagtcgct gaatatgaga gtgccaaaga 17160
tgctctacct aaacatagca tccgttatat taagggactt ggctctttgg aaaaatctga 17220
atatcgtgag atgattcaaa atccggtata tgatgttgtt aaacttcctg agaactggaa 17280
agagcttttt gaaatgctca tgggagataa tgctgacctt cgtaaagaat ggatgagcca 17340
atagtttact ttaccacaag gatgtggtat aattaattgg gcaaatgagg atattgaaat 17400
gaaatcatat aaagtaaatt tagaactttt tgataaagca gttcatcgag aatatagaat 17460
cattcaacgc tttttcgata tgggagaagc agaagaattt aaaaaccgct ttaaagatat 17520
tagagataaa attcaatccg acactgcaac taaagatgaa ctactagaag ttgctgaagt 17580
tattaagcgt aatatgaatt aatgaggaaa ttatgattat caccactgaa aaagaaacaa 17640
ttcttggtaa tggttctaaa tcaaaagcat ttagcatcac agcatctcct aaagtattta 17700
aaattctgtc atctgatttg tatacaaaca agattcgcgc agtagtccgt gaattgatta 17760
ctaacatgat tgatgcccat gctctcaatg gaaatcctga aaaatttatc attcaagttc 17820
ctggacgttt agatccacga tttgtttgtc gagattttgg tccaggtatg agcgattttg 17880
atattcaagg tgatgataat tctcctggtc tgtataattc atacttcagt tcatctaagg 17940
ctgaatctaa cgatttcatt ggcggatttg gtttaggttc taaatctcca tttagttata 18000
ctgatacatt tagtattact tcgtatcata aaggtgaaat tcgtggttat gtagcttaca 18060
tggatggtga cggtccgcag attaaaccta cattcgtaaa agaaatgggt ccaaacgata 18120
aaactggtat tgaaatcgta gttccagttg aagaaaaaga ctttagaaac tttgcttatg 18180
aagtttctta tatcatgcga ccattcaaag atttggctat cattaatggt cttgaccgcg 18240
aaattgatta ttttccggat ttcgatgact attacggcgt aaatccagaa agatattggc 18300
cagatcgtgg tggattatat gctatctatg gcggtattgt ttatcctatt gatggtgtta 18360
ttagagaccg caactggtta agcattcgca atgaagtgaa ttacattaag tttccaatgg 18420
gttcacttga tattgctcca tctcgcgaag ctctttcatt agatgatcgt actcgtaaaa 18480
atattattga gcgcgtcaaa gagcttagtg agaaggcatt taatgaagat gtaaaacgat 18540
ttaaagaatc tacatctcct cgtcatacat atcgcgaatt aatgaagatg ggatattctg 18600
ctcgagatta tatgattagt aattcagtca aattcacgac taaaaatctg tcatataaaa 18660
agatgcagag tatgtttgaa cctgacagta agttatgcaa tgcaggagtt gtgtatgaag 18720
taaatcttga ccctcgactg aaacgcatta agcaaagtca tgaaacttca gccgttgcat 18780
caagttatcg tctgttcggt attaatacaa caaaaattaa tatcgttatt gataatatta 18840
aaaatcgtgt taatattgtc cgtggattag cgcatgcgtt agatgataaa gaatttaata 18900
acactttgaa tattcatcat aatgagcgtc ttctgtttat taatccggaa gtagaatcgc 18960
agattgattt actccctgat attattgcaa tgtttgaaag tgatgaagtt aacattcatt 19020
atttgtcaga aattgaagct ttagttaaaa gttatattcc aaaggcagtt aaaagtaaag 19080
ctcctcgtcc taaagctgct actgcattta agtttgaaat taaagacggg cgctgggaaa 19140
aagaggaact gtttacactt acgtcagaag cagatgaaat tactggttat gtagcataca 19200
tgcatcgttc tgatattttc tctatggatg gtactacatc gctctgtaat ccgtctacga 19260
gtattttgac tcgtatggct aatcttattg gcattaatga attttatgtt attcgtccac 19320
ttttgcagaa aaaggtaaaa gaacttggtc agtgccaatg tatttttgaa actctacgtg 19380
atttatatgt agatgctttt gatgatgtag attatgataa gtatgtaggt tattcaagtt 19440
cagctaaacg atatattgat aaaattatca agtatcctga gttagatttt atgatgaagt 19500
acttcagtgt agatgaagtt tccgaagaat atacacgact cgctaatatg gttagttcat 19560
tacagggtgt atatttcaac ggtggaaaag ataccatcgg tcatgacatc tggacagtaa 19620
ctaatctttt tgatgtatta tcaaacaatg cttcaaaaaa cagtgataaa atggttgctg 19680
agtttactaa gaaattccgt attgtttccg acttcatcgg ttatcgcaac tctttgagtg 19740
atgatgaagt ttcccaaatc gctaaaacta tgaaggccct tgcggcctaa taaggaaaat 19800
tatgtacaat attaaatgcc tgaccaaaaa cgaacaagct gaaattgtca aactgtattc 19860
aagtggtaat tacacccaac aggaattggc tgattggcaa ggtgtatcgg ttgacacaat 19920
ccgtcgtgtt ttgaaaaatg ctgaagaagc taaacgccct aaagttacta ttagtggtga 19980
tattacagtt aaagttaata gcgatgcagt tattgctcca gttgctaaat ctgacattat 20040
ttggaatgca tctaaaaaat tcatttcaat tactgttgac ggtgtaactt ataacgcaac 20100
tcctaatact cattcaaact tccaggaaat tcttaatctg cttgtagcgg ataagctgga 20160
agaagctgcg caaaaaatta acgttcgtcg cgctgttgaa aaatatattt ccggtgatgt 20220
tcgaattgaa ggtggaagct tgttctatca aaatattgaa ttgcggtctg gtttggttga 20280
tcgtattctc gattcgatgg aaaaaggtga aaactttgaa ttttattttc cgttcttgga 20340
aaatctgttg gaaaacccaa gccaaaaagc ggtatctcga ctctttgatt tcttggtagc 20400
aaacgatatt gaaatcaccg aagatggtta cttctatgct tggaaagtag ttcgtgacaa 20460
ctactttgac tgtcactcaa acacctttga taacagtcct ggtaaagtag ttaaaatgcc 20520
acgtactcgt gtgaatgacg atgatacaca aacttgttct cgtggtctgc atgtgtgttc 20580
taaatcttat attcgtcact ttggcagttc aaccagccga gttgtaaaag ttaaagtaca 20640
tccgcgtgat gtagtatcaa ttccgattga ttacaacgat gctaaaatgc gtacctgcca 20700
atacgaagta gttgaagacg ttactgaaca atttaaataa gggcttcggc ccttttgttt 20760
taagagaaat tatgattccg acataaagga aagtttaaat gcagaaaacg aatccgggtt 20820
tacagagact atttcagatt ccgacattta ccctatcgaa cagcgattta accaatgaaa 20880
tgaaggtcaa aattgctgat actgcaagat actctttaaa acaaaatccg aatcaggata 20940
aggcagaagt tatcgaaaga tgccgtatcg ctgtgtacgc agagtttttt gtagcagatt 21000
ggctgagcgg gtatgttaac aaaggtcaag aagatgtcga tgatccgtac acgtatgcat 21060
gggatgtttt agcacatcca aaatactgcg ggctccgtgt agaagttaag acacatcaaa 21120
ctgactcgcg ttggatttcg gtaacaacgg gatgcagcgg agaatatcca tatggttctg 21180
gaataaatct agggcccatt ctaaatcacc aggtcgcgga ctgtataatt atattcaaca 21240
ctaaagaaat tcatccaggt gtcatccagt acactccgaa gttcatcggt gacagagaag 21300
accttcgtaa ggttgtaaga aaaagcaact acaatggatg gtatctttcc atttaaaaag 21360
ttttcacaaa acagtttaca taccacaagg accgtggtac tatacaacta tcaactgata 21420
cggatttgga gaatgaaatg aaaatcgctg agactgagct atgagttcat tatggtggtg 21480
ttttgtttgg ttaattagta ttccattgat ttgtttaaca tttacttttg tgatgaggtt 21540
attatgaaaa tttttaattc tgtacttatt gcttgtgcgt ggtgggttgc gcaagtttcg 21600
gcagtagtga ttggtattca catttattac gaatattttt aaaaaagttg tttacaagac 21660
tgttcctctg tggtattatt accctatcaa ctacggagga acagaaaatg aaaaagattg 21720
ttaaagctat atggaatgta gttataatac taatagtttt gagtatattc ccaatcgttt 21780
taatgattga tatattaaac gcttactttg gatttatgtg aggaaaatat gaagcgtaaa 21840
cgcagtgctt ttacatttat tgaatgattt ttcgataata tttttccggc tttattcatt 21900
ttcatgctga ttttcgcctt gggttcagtt gtagttggaa tctatttgat ggcagttgtc 21960
ggaatggaca ttcatcaaaa tggtttaaaa tccgtagttg aaacaatttg gaatggcgta 22020
aaatgatgaa tttgctgagt ggttggtttt atattcttat gttttacatt ggtgcaaatt 22080
tcccatattg gatgggatgg tcaacaactg cgtttggatt ttatactcct tgaggtgaat 22140
tatgaaaagt tttaaagatg taaaagttgg tgaaattttc tgtttagata atggtgatca 22200
gttaattcgt atttcacctc ttaagagcac tagcgagaaa ccgacagtta atgctacttt 22260
agcaaataac agtaatgaac gtttctgtat tgaaaatgat actgaaactt ataccgtaga 22320
agagttttgg gaattgagcg tcgactgcga cgattaattt aatggccgtg tgtattcatg 22380
cggccttgga gtagaaaata atttagagga aattaatatg aaatatatga ctgttaccga 22440
tctgaacaac gcaggcgcta ctgttattgg tacaattaag ggtggtgaat ggtttttagg 22500
aactccgcat aaagatattt tatctaaacc tggattttac tttttagtga gtaaattaga 22560
tggtcgtcca tttagtaatc catgcgtatc tgcacgattt tatgtaggta atcagcgttc 22620
taagcaagga ttcagcgcag ttctaagtca tattcgtcaa cgccggtctc aacttgcgcg 22680
tactattgca aataacaatg ttccatacac agtattttat ctgcctgctt ctaagatgaa 22740
acctctgacg acaggatttg gtaaaggtca gttagctttg gcgtttactc gtaatcatca 22800
ttctgagtat caaacacttg aagaaatgaa ccgtatgttg gctgataact ttaaattcgt 22860
tttgcaggca tattaatgag taatttccac aacgaacatg tgatgcagtt ttatcgtaac 22920
aatcttaaaa ctaaaggcgt cttcggacgc cagtgaggaa aatatgaata tcgcaaaatt 22980
attaggagtt atttcattta tttgttggat agtagcatgt gttttaacta tctgtatcga 23040
tgctagcagt gtgttttcac aagctttagc ccagggtatg tgtgcatatt taacatttgt 23100
gttgttatct aatgattaag aaaatcttgg gctattcact agcccttgct actttattgg 23160
tagcgttata ttacggaata atgttcggat taattcaagt tgtgcttttc atttctgatg 23220
ttattatggc actacattca ctagtatggt aaatttatgc aactgaataa tcgcgattta 23280
aaaagtatca ttgataatga agcattggct tatgctatgt acacggttga aaatcgtgct 23340
atcccaaata tgattgacgg atttaagcca gttcaacgat ttgttattgc tcgagctctt 23400
gatttggcac gaggaaataa agataagttt cacaaacttg cttctattgc aggcggtgta 23460
gcggaccttg gatatcatca tggtgaaaac tctgcacaag atgcgggggc tttgatggct 23520
aacacttgga ataataactt tcctctgtta gatggtcaag gaaactttgg ttctcgtacc 23580
gttcaaaaag cagcagcaag tcgttatatt tttgctcgtg taagtaaaaa tttctataac 23640
gtatataaag atactgaata tgctccggta catcaagata aagaacacat tccgcctgct 23700
ttctatttgc ctattattcc tactgttctt cttaatggcg tttccggtat tgcaactggt 23760
tatgcaactt acattcttcc tcatagtgtt tcttctgtta agaaagctgt attacaagct 23820
cttcaaggaa agaaagtaac taaacctaag gtagaattcc cagaatttcg cggtgaagtc 23880
gttgagattg acggtcaata tgaaattcgt ggaacatata agtttacttc acgaactcaa 23940
atgcatatca ctgagattcc gtataagtat gatcgtgaaa cttacgtgag taaaatttta 24000
gacccgcttg aagataaagg cttcattacg tgggatgatg cttgcggtga gcacggtttt 24060
ggcttcaaag ttaaattccg taaagaatac tctttgagtg ataacgaaga agaacgccac 24120
gcaaaaatta tgaaagactt cgggttgatt gagcgtcgtt cccagaatat taccgttatt 24180
aatgagaaag gaaagctaca agtttacgat aacgtagttg atttaatcaa agacttcgtt 24240
gaagttcgta aaacttatgt ccaaaaacga attgataaca aaatcaaaga aactgaatcg 24300
gcatttcgtt tagcctttgc caaggcacat ttcattaaga aagtaatttc aggtgaaatt 24360
gttgtacaag gtaaaactcg taaagaactg acagaagaac tttctaaaat tgatatgtat 24420
tcttcttatg ttgataaact agttggaatg aatatttttc atatgacttc cgacgaagca 24480
aagaaacttg ctgaagaagc taaagctaaa aaagaagaaa acgaatattg gaaaactact 24540
gatgtagtta cagaatacac caaagattta gaggaaatca aatgagtcca tttataggta 24600
tcacaagcgc tgcattagta tctggtagca ttttactggc gggtttaggt gttgttccag 24660
ccgtagcagg aggtcttctt gcgttcggaa ttcaacgtgt tatcatgaca gttatcacag 24720
tcatgcagta attttaggga gagctgaggc tctccctttt ttatttcaaa aattttttca 24780
caaaacggtt tacaaccaaa gcatactgtg gtactataca actatcaact actgatacag 24840
aattacggag attagaaaat gtctaaagta acttacatca tcaaagcttc taacgatgtt 24900
ctgaatgaaa aaactgctgc gattttaatt actgttgcta agaaagattt cattacagct 24960
gcagaagttc gtgaggtgca tccagattta ggtaacgcag tagttaatag taatattggg 25020
gtattgatta aaaaaggcct ggtggagaaa tctggtgatg gattaatcat tacaggcgaa 25080
gctcaggata ttatttcaaa tgcagcaact ttatacgcac aggaaaatgc tcctgaactg 25140
ttgaaaaaac gagcaactcg taaagcttct gatatggaag aagataaaga cttcatgtta 25200
aaacttttag atgaaaatgg atttgttctt aaaaaggttg aaacttaccg cagtaactat 25260
cttgctattt tagaaaaacg cactcacgga attcgtaatt ttgaaattaa taacaatgga 25320
aatatgcgaa tttttggata caaaatgatg gaacatcata ttcagaaatt tactgacatt 25380
ggtatgtcat gcaaaatcgc taaaaatggt aatgtgtatc ttgacattaa acgctcggca 25440
gaaaacattg aagcagtaat caccgtagca tctgaactgt gaggaataaa taatgaacaa 25500
gttagaaatt atcaatgaac ttcgtcgttg tgcagaaccc actcaagagg ggtgggacat 25560
ctggtatcat ggagcttatc ttggaactat cgtaaagatt aagactggta aatacatgat 25620
tattcgtgaa agtaaagatg ctccagtagg tattcgcaat aattttatgg cagcgataag 25680
ttcatttacg gatgcagctt acgaaattta ccttgttgat tataaagaat tccaggaatc 25740
tcaaccagtt attcgttcaa ttggtgttaa caaagctcaa cagaaaactt tgtggcagcg 25800
tattaaagga tggtttaaat gaaaactttt aaagaacgtt tagctctgtt agataaagct 25860
ttgtcgcgtg agactccgga aagtctggct gctaaattag cttctcacgg tggtgaatat 25920
acagaacaaa atgttttaga tgaagttcct gaaatttgtt ggcagactgc gtactgggat 25980
gaaaaccaaa agtatcaacg acgaattgtc tgtgcagcca accgttttaa attaaaagat 26040
ggacgaactc ttattattcc aggtgctcgt cattattcta aagatatggc agaagtttta 26100
gatgtagtta aatctcaatt agttactcag caagtttgtg atgatgacca agggtttatt 26160
gaccaatata gtaattattg gacacgtgaa gaagcaatga ttattgcaac ttacgctgga 26220
caagtacgta ttgaacgtgg tggtagtgaa aaagaacttt actctgagga cctttactaa 26280
tgaatattaa acagtttcaa attgatggaa ttatgaatca aatccaggcg ctggaatatg 26340
ctaataaaat gatgtcaacc aaatggggaa tttatgccaa tgaaccggca tttcagttct 26400
gtaatatgga attcactaaa aagctcgtag gaaaagatta tgtgtgccca tttagttctc 26460
cagtaaatgg aatgctaaaa cctgctttac gcgatcttta tattgcgatg aacgaagaaa 26520
tgataaaaga attaaaacgt caactgaagg tgattcaatt tggccaggga aattaattca 26580
aaatctgatt attttaattc tctcaatgat aaagataaaa atctaataag gcattttatt 26640
gttgagatgg gatatactga tacacgtgat ttaagagaac atatatttga atgtggtgta 26700
gctaaaaagt tttcattcac atgcaaatgt ttaagagagg taattcagca ctatgaacaa 26760
tttagtcgca aaacataatt ttaataaagc ttctgttcat aaagataaga agaaagcgtt 26820
taaagaatct aatcgcaaac agaaacataa ggggaaggtc tatgattatt gattctcaat 26880
ctgtggttca atatacaatc aaaattgata ttctagaaaa gctatataag tttctaccaa 26940
atttatacca ctcaatttgg aacttataaa gacctctcaa aagcaggata tttctatgta 27000
attccagctc caggaaaaag tattgatgat gtattaaaaa ctataatgat ttatgttctt 27060
gattatgaaa ttgaagatta tttcgaatga gtcataatct tgaaaaggta atcgagcata 27120
atgtagctca ggaacgtgag tcgttcaaag aattcgtaga aaaaattttt gaagaaaata 27180
acacagacca gtttacaaat caagtgtctg atgatattat aataaagtca actaattgag 27240
tggtatagtt aatgaataaa aacattgata cagttcgtga aattattact gttgcgtcta 27300
ttttgattaa attttccaga gaagatattg ttgagaatcg tgctaatttt attgcatttc 27360
tgaatgagat tggagtaacg catgaaggta gaaaattaaa tcagaattca ttccgtaaaa 27420
ttgtttctga attaactcaa gaagataaga aaaccctcat cgacgaattc aacgagggtt 27480
ttgagggtgt atatcgatat ctagagatgt atacgaacaa ataattattt agcccttcct 27540
aatattcttg ccgcctgagc acatattgat tcaaggcggt cattacttat atgatcattt 27600
ctataccagt acatggttat tgttccagca tagatattat ccaaattgaa atatggacaa 27660
ctgtacatgt aatttatttc gggagtaggc tttttggttg gtaaaaaagc aaattttgag 27720
ttggaataat aatgacgtcc atttaaatga actgcatatt catccatagt tttatcaaca 27780
ggatatcctc caagtgattt ttcacttatt gttgaaggta attttccttc atatgctata 27840
atatcaacaa aatagtttaa gtttttaggg cggaaagaat acaccgcact aaagtctgcc 27900
tcagatgata tatgaactat ctggagttgt tccagggcga cagattcaaa gcgtgcattt 27960
ctttcctttt caataatttc actgtatgtt tcatactttg attgcttata gtactcaaat 28020
aaactatctc ccctatacca aacaatcgcc attataaaca aaagaattac gacagctacc 28080
cgggaagcaa gaactttccc ggtagcgtta tctttgaaca agcgatctag aacaccaaac 28140
agaatatcag agggcgaaaa tgatattcta ggtgctgcca tagaccctcc ttttaaggat 28200
atttattcaa aattatactc ttgaaccata tattgtacca actttagtcc aagttggagc 28260
attaccagta acagctttac ctgctgcgcc gccgttatat tctgatcctc gaccgcgaat 28320
attacattta cctcctgcat caccaccatt cccaccattc ccaccattat agataccgtt 28380
gacagaccct ttaccgggtg cagaaatagt accagcggta gcaccttgtt tcatattagc 28440
agaaccacca gcagcgccaa atggacgacc gcctcctccg ccgaaagtca atttcattcg 28500
tgaaaaagga gagtagtatc cgccgccacc gccgccaccg cctcctgcga taacaccatt 28560
gttgttaata cgtaatctag ttccaattcc gttatttatt gcagttcccc ctgctccacc 28620
ggcagagtta 28630
<210> 25
<211> 10309
<212> DNA
<213> partial sequences of Bacteriophage EK88P-1
<400> 25
acgtatgcat tagttaatga gctaggaaaa tctaagcatg gaacaccagt agattgagaa 60
acaatatttc ctgtaatagt aataacaaca ggagtacttc cttgggcttt tatccaattt 120
attagtgtgt ctttattata agaattgcta gcaccaatgc tgtaatatac ttctttagat 180
tgtccggcca ttgagctcat ccaaccagga actgaaacac gaactgctct catcgcagca 240
tccatccaac gttgtccagt ttcattcacg gcagattcgc caatccagcc aggaacacct 300
acaattgcca ttaaaaatcc ttagagggcc gaagccctct tttacataag tttagattca 360
agttctttta cacgagaaga aagtgttttc acagcttcaa ccagaagagc aatctgggct 420
tgagaagaaa cagtgagtat tttattaccc ttaatatctt caacttcgcg aactgcttct 480
ggtaaaacat cttgcagtgt ttgagccaca atacccgctt cagtctgaac aatttcaccg 540
cctatatagt cagctttatc atagattaaa ccatcaagct gttcaacctt ttcaagagca 600
ttttcaatag gtctgaaatt agatttcaaa cgaatatcag aacgaatata aacgtttggg 660
gcatttatat tcatgtcaga ataagtgtca cccgtctgga atctcattcg gcggtcggag 720
ttagtaatga tatcaagaat tccgtcaccg gattgtttaa ttccagtatc attatcacca 780
aatgctatac tatttccacc aagtgcgtta ttgatattaa taccaaatga attcattcgg 840
ttaacaccat ctacagtagc attatttact acaaagcggt tagctccacc tggagttttt 900
tcaaagtaag caatatagtt agtttcatct gcaatttcaa tgcggttacc gcgagaagca 960
tcgccagcat gaaatattct catatttctc gggttagcac cagacttatc aaagttaatg 1020
cttccattat ttttgatgtt aaggccattc caaaactctg ataccccaga aacgctcata 1080
gagtttgaaa tagttacttt accggaagca atattaatag aaaaaggtct caagctatta 1140
taagaacccg aggctttagt tttatcagta tcggtatttt tatctgttaa taatatgtgg 1200
aacgtagtac catcattata aaacagagca gctgcagagc cactttcgtc gccgttagat 1260
ttgtgacggt atcctatagt agtatttgcc acaaaagttg catttgtaga aatgttagaa 1320
ctacccgcgt caaaaacgcc tgagctatta ttaagaagtt taaaaacacg acctttaaca 1380
atatctacag gaagctcttc taccggcgat tgtgtaggtc catataatcc atgaactatc 1440
acagaagcat tttctgaagt gctatattct atagtaagtc tatttaaata agtgccacaa 1500
ctaatataaa catcatactc atcgcctgag gtattaatat acgcaatatc tttaatagca 1560
tctgtttcac gttgccataa aacaccgtta attcctttag gtgtattatt accagaacgt 1620
aatacaattt cattaattgt tgcttgtttg aaaataccaa cgttaaaacc ggaaccgcct 1680
gttattttaa attggaccgt agctacacct tgaggcatag ttactgttgc caatttatac 1740
caaccactta cagaagaata gttaatccag cccgtggtaa ctttgcggtc taaagtagta 1800
ttcaagttag caaagttacc agaaccaccg gtaatattac catcagtacc aagataaact 1860
ctgccgccag cggaaatacg tttaggagat acaaaatcac ccgatttagt aaattcccat 1920
ccgtaatcag caatctgagc accagtagaa ctaccgtctc cgccagcgtg ataatggaca 1980
cggaaattac cgttattcaa taaagtacca attgaataac agctattacc ctgaacatac 2040
cgctgtttaa tcattggaac ataagtgctg gtatcatcac ggtcaatatt catgtagaat 2100
ggtgctcgaa cgttttcgtt attctgggaa gcaaatgaac ctgcaccagc tgaacgacca 2160
tttgcatcca tcaaagcatt tatataagca ccgttttcta agtccatacg gaaattaggg 2220
ttaattttag aatgactgtt aaccgtaacc aggaatgcgt tggtatcaat atttaacagg 2280
ccattgccgc gagccgagtt gcctatcatt aaagaatggc ctatattaat tgaaccggta 2340
cctaattcaa tactaaacgg acgaaggttg cttattgcgc cattttcccc ttcatattgg 2400
ttggttggga taatatgcaa tgatgtttct gaacgacgga aaatggcacc ataccggtcg 2460
ttccaaattc tcaatgcatc gttaacaccg ccaattttaa cctgtcctgt tatattagag 2520
ccgcctctaa ttgttgcgcc gttttcaaaa gtaactccac ctttaaaagt acctttacct 2580
gatgtagtta tatcaccgag cccgacgata tgcccagttt ctacagttcc gttaaattta 2640
aagttaatcg gacctactgt ttgacctgat gcaggattag tacgttgagc gtagaaataa 2700
taaccttgtg aatctgaaac ttcgaataca gtttctctat tacctggagt tgagttaaat 2760
gagttacccc atgctttaat ggttacagta tttttattct gaccattacg agtgcctgca 2820
ccccagttaa tggtttttgt cccgtcaaca cctgtaggcg ctttaaataa caaagcattg 2880
gtattatcat cacctgataa aaataatcca gtacgcattg aaatacgttg ggttgagtca 2940
aatgtaccat ctgctctaat agcaactcta ttagacccag ttttaatgtc taaaatacct 3000
ggctcaacaa taagtccttc ggccatacca acagccatac gacctgtacc acggaaatag 3060
tgatacatct tggcattgct gctataacct atatgagtct gaccatcgcc gttattatta 3120
ccatcaatat cggtgcgtgc ggtaaacatt gcttggttgt tatttgggaa atcccaagta 3180
gaaccggaat ctcgactata accaaccatc aattttttag tactgttaat accgttattc 3240
aaaatagtcg cagaagaaat accgttagcc atcaggtcat aaacgccatc acggacccat 3300
ttaataccgg tgtcattatc accaattgca ataccgatag aaatggcaga atctaaagga 3360
taacgtccat ttgccccgtt atcaggaaga cctactgaaa tagatttacc tgcggtaata 3420
cgcccagtgg tatcaaacgc ccattggaaa gacgaaggcc ctacgccagt ccaccaagaa 3480
atttcttgcg gctttcctga acgacaatca actatttcat ggaaaatact agaagtattt 3540
gaagcccgca ttttacgcat gtagttcaat ccgtttgtat cacggtcaga accatctgct 3600
ggtggattat aaatccaagt aggtaaagaa acaatgtcat aacccgtgtc attattcggt 3660
ataaaggttt tagaactcag gttaatattt tttgtattga cgcgcggtgc agaaacaaat 3720
ccagttgccg agttaatatt acctgaagcc gaaatattac ctgcacggac ttcaatactg 3780
ccattattta caataaaact accgtttcga ttaaaagtcc aatattttga atcaccagat 3840
tcattgatat attgaatttt aaaacttcct tcgtttacta acgtaccaac agaaaaagtt 3900
ccatctttat agcgttgttt aattagcgga tggtattctg aagtagaagt agttgaactc 3960
aaatcggtaa agataggagc tttagtttta tgttggtttg cccaagcacc attaccagca 4020
gttttaggta aaaattcaat atattttcct gcataaacaa actggtttcc attaagatta 4080
tatgttccat tttgtaaata atcaccagtt tgagtgatat ttccactgat actaccgcca 4140
gcagaaatgc ttaagtcaat gatatttcct gaatcatctt tagtaaaaat tgttctatct 4200
tttaagttta tagccaattc accttcggct aatattgaag cagcaggacg tgcacctgcg 4260
gttttgcttc ttttaaattg tatttgtttt aaagtagcca taagtcctct taataatagc 4320
cgaaatcttg aacagaatcc ttaattacga tttggtcaaa tcgtggaaca tgtgaaggtt 4380
gagacgcagg attctgcgag aaaaagtttg gcgctgttaa attacctgtc atagtgtcac 4440
cagaacgcaa cactctagag ttcgcatttg ctgtaacagt atttattgct ccatcaacat 4500
agtcctttct agtaaggtca ttcgctgcta taggagcagc cgcattactt cttatttgac 4560
ctactgctgt cacaacgcct tttgtactaa tatcaccatt acgtgcatta attacaacag 4620
ttcggtctgc tgaaccttgc gatgatttaa aaccaatacc attccacgaa acgatgtcaa 4680
tacttgccat agcaaaagta gctgcatcac cgttacctgg ataaacaccg cactgttgac 4740
tactacctat agtaggaaca tgtactcctc cattaaatcg aacagtcgcg gcgtaagtac 4800
caccattagc tttagaaacg aaatcgttat cagcagcttg tggtttatta tattctgaat 4860
atattttaaa tgatttatag agtacatcgt caccggctgg attcaatgga aaatttcctt 4920
gatgccaaat gacagagcct ccggttgttg aacctacttt taaatcagcc attctatgcc 4980
cctttatttt aatagtattt ataaagaaaa agggaacccg aaggctccct caatttatac 5040
ttctctaaat tcttgcccaa atactttacc agctttagac gatgcttgcg taggaagtgc 5100
cattatatcc ggaggtgaag cagattcaca gatataatta acacgaatgc cgttgatacc 5160
aaattcagca ggtttcgaaa tacttccatt tcttgacact tccgaaaagc ttaaattcct 5220
catgccacct tgaccagctt gtgcagttct ttgcgcgtat atcgtaaatc ccacagcatt 5280
ttctggaaca actacataat cttcctttaa ttcccaagac ccagcttgtc cggtgaactc 5340
agcttgtgtc gaggaaatat atccatttga tgcgttataa aaacggatgg atatatttgt 5400
agttccaaga gcaagtaaat cggcatcagc atataactga gctttaagat aaagaacatc 5460
gccaggaatt aaattataat cagagagttt acttatggca gctgaagttg gtagacgtgc 5520
aatttcgtta ttagttccac caactgctga cataaattgc tcaacgcttt catacgttct 5580
tcttggaaac ccggtagctc cgacgtcttc taaactgtca aatacaacat ctaaaatagt 5640
ttgatagtca tctgtgcttt ttctattact tagtttaaca tgctctaatg caatagctct 5700
tttagaagaa gtgtaaaaag cagcatatga tacgtcaaat cttgacaata tagaatcaga 5760
tggaaaagca gacgttcctg cggttcttag ccaagatact acttcaggag gaaaattaac 5820
ttttccacta gttaatatag caacaagtct attattcgtc aaagaattca tgaaactaac 5880
aaaagcagct gatgtagtat catttgaagt agaaaaagca tatgacttac tatcaactaa 5940
tgctccggtg gaagggtcaa aaactcttag atgaagacct gcgctaaatg tttgatttcc 6000
gacaggatta tcttgaaatt taacatatgg tcctgctgta gaaagcgggc aagaacccgc 6060
tatacttatt ttgtatctta ctgaattact ttccgataaa aatggcgttt ggacatatcc 6120
ttgtccaaac tctgccataa atttttccat aatacctctt attcaatcca ttcaaattta 6180
acagatttat tcactgggtc aggaataatg cgaacattac caattcgtaa gaaatcacga 6240
atagtaagat tccccattgt agcattatca gatggtaaag caccgatatc agacggctga 6300
ggagggttac ctccatcaaa tacctgaaca aaacttgacc aagagttttt ggttttctgc 6360
catgtacgtg tccagcgagt ggtacgtgct tctggggtcg ttggataagt aatccaatct 6420
tggtaaagcg aatcaagtgt gttaccaaac tgagtcaatg taccaggaga tttaacctct 6480
tctccgcgtt ctaagtatgg aagtccagtc acttcattag ttttttcaac cattttaaaa 6540
taacctggga actggttata agtagctgaa tcattaatgt caattgacca gaatcctaca 6600
gtatcagatg ttggcgcacg ggtgtatagg tcagcagttt tagtgccctg agaacgaatt 6660
ctcgagttaa cagttaaacc acctgaattt atagtagcac ctttagcaat gattaagctt 6720
tcgccaatcg ttacttgacc ggatgcatta ttaatagcta aaggacgtaa tccattaaat 6780
ccgccagtct gatcacccga tgcagtgagc ataaaatatg tgcttccgcc atcattcctg 6840
ataaagaatc catgattacc atttattgct ctgaaagcat tcgatgattt actgataagt 6900
tcgccattag cagtaactga actaccaaat gttgcaacgc cgttcgcgtt caaagaaccc 6960
gaagcattga catttatcgg catcacagta ccattgatac taaacgttat attcccagct 7020
ttattacgct gagaataaaa gtgattagac gtttcatcac caacttcaaa tacagtagaa 7080
cgtgttgtat ctgaaccgcc gccaaactga tttccccaaa ctctgatagt catcgtctgt 7140
actgggttag ttccggtttg aggtcctttc tcaaaaatca gacgagttgc cgttccagta 7200
ttagaaatag ttaatgtact atttgccgaa actgatccac caaacgtagc agtactagat 7260
gatacaagag gggcactcag attcgtttgt tgggttaagg ttagtgaacc attaaccgtc 7320
tgcgcaatat ccctacgaat gaactgagat gaatctagac catctaataa attcgcgtca 7380
gcggcttttg cttttaatgg caaataattt gctaatacac ggtttaattc atatggtgat 7440
actgcatagc tatttttctc atataactct aagtcctgcg ttgaaccagc tgtatcatta 7500
ccaacgaatg taattgaacc agatgaagtt ttaacaaagc ctcttatcgc agtagtagct 7560
gcccaagtag gttcactctg tacaatccat tttaaatttt ttggagatac agcagtattt 7620
gctgacgttc cagttacagt ttcagactga gttgcaactt taataacacc ttcctgcgat 7680
tcggtagatt tagtacctaa aagcttttta ggagttatta aaacattatc taatgttcct 7740
gcagcagctt caacttgtgt agccacacga agtgtaccac gctgtgtctc atttgcttca 7800
agaatattaa gggtataatg gtcccagaga gttcctgatt caactaatcc agatagagca 7860
acaacagaag tacgatcagt actattaaat ctagttttaa tttttaatgg tgtagagata 7920
cgagtatcgt cgacgcctgc gtcgaattca acttgtgtag caatttcagc tataccactt 7980
aaactttcag ttgctttacg gtcatttaaa gttttaggag tgactgcgcg agtataatca 8040
gttcctgtat taacttcact ttgcgtagca atttcaatta aaccaattct tccatcagtt 8100
gatgtctttt tatgtaacgt ttctggcgtt acaaccgcat ttgcccatcc ttcttgactc 8160
tgtccagcaa ttacttcact ttcaactgct aaaattactg caccttgttg tgttggagta 8220
gctttatact gatccagagc tttaggcgaa acaactaaat tattaatgtt tttattataa 8280
acgtttgtac catttaattc acggctagaa gctggagtag cacctgcagt agatacaaaa 8340
gttacaatac cagataatga ttcagaacct tgacgagctt gaagcttttt aggagtaatg 8400
attgtagtat catcagtacc tgtattagtt tcttgctgcg tagcaatttc agcaacacct 8460
ctacgagttt ctgtagcagt tctttcattc agctttttag gagtaatgat aagatcatca 8520
gcaaaagaga atgtggtgtt ctgattcact tgagtagtag ttgctattct tgcaatacct 8580
ctacgagttt cagtagcagt acgattagct aacgtttctg gagtaattgc taattctttt 8640
tgcggagaat tttctaaatc gacattagct tgcgcttgtg tagctaaagc aatcacgcct 8700
aatcttgctc tagtagaatc atttaaagaa tcaactcttt ctacggttgg aacgttttgt 8760
tgtacaaccc agtattttcc atcagaatct tctatataag caagttgtaa aactggaaca 8820
taattagttt caccgttaaa aactaattct tgaacagtca cccattcagc ttcaggtgga 8880
tactctgaac gttttgggaa ttgcagcaat tgaactgaag aagcaatttt atcttcaccg 8940
gcagctttga ttttaactgt ttgtcctttt ctcatgtaat tcatggaaat tttaacagta 9000
tcaccaacag aaatattagt tggaagctga agctcaattg tttgagttgt tccattattc 9060
gcaccaaata ccataacttc ttcatttgga cgaatgtttg aattagttgt tatgatacgt 9120
aaacgtgctt tactgtcccc gtcaaataat ctccataatt tctcattatc atcatacatc 9180
aagaaaccgt caatcgatgt acggccttca atggaatgag ttccatcttc ttgcactgat 9240
gtcgtttcat catatgtagt aacaattgta tgataaagag ggtttaattt atccaaatcg 9300
acgaaattaa taatatcgcc gtgattagca aatctcggaa gtttaatatt tatcggtgca 9360
gcagaagtaa atctacgtac gataaaatcg ttggattgtg cttgataagt attcgctggt 9420
gttacaacta cagcttctct actataatca gctacataca tttgccacag acgattacta 9480
aaaattaaaa ctaactgtga ctttggatga gtcattagta ctgaacgtac ctgttcacct 9540
ctaaagttta caatactttg cactggagct acaattaaaa cttggttaac tccaggtttt 9600
cctccaatat cttggagaac gatagtatca ccatcaattg gagaagacgg taaagtaaac 9660
gtaatgtcat ttccagctgc agtgttaacc gaaatagctt caccggattt taattgatat 9720
gaaccagatg agactgtaat ccagttagca tcggtacgta atgctctcca gcgtccgcta 9780
ttaaaagttc ctgccggttt tggaatatca tttatagcag cccaaaagcg gttatcataa 9840
atgattacaa aatcttttaa atatccacga gttggatcgt attgttgaac tgtgttttct 9900
tgaattaggt aatcaacgtt aacaccgtca gttcctacgg cacgatcagc taaagctacg 9960
ttgattattt tatcgccacc tgcgtccaga ccatcttctg ctctgaactt tcttttaatc 10020
tcggccattc tcccgggctc ctattgtgtt ttcaataata agtatttata cttgtttact 10080
ttaagattcg gatggtatat aatagaaatc tcactaattg aacgaggttc atatggattt 10140
agaaatgatg ttggatgaag attacaaaga aggaatctgc ttaattgact ttagtcaaat 10200
tgcgctttca actgctctgg taaacttccc agataaagaa aaaattaatt tatcaatggt 10260
tcgtcatttg atattgaact caattaagtt taatgtcaaa aaagcaaaa 10309
<210> 26
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 26
tatcacccat gttccacgct 20
<210> 27
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 27
tggtattact cgtccgcagt 20
<210> 28
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 28
ccaagtgcca gtcctaaacg 20
<210> 29
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 29
atgggtcggg ttactggttc 20
<210> 30
<211> 22
<212> DNA
<213> PCR primer sequences
<400> 30
acccaatctc ctattctgtc ca 22
<210> 31
<211> 22
<212> DNA
<213> PCR primer sequences
<400> 31
tgactgatat tgattctggc ga 22
<210> 32
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 32
ggtttcaact cgagcaaggg 20
<210> 33
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 33
tcggttgtat cttgggctga 20
<210> 34
<211> 21
<212> DNA
<213> PCR primer sequences
<400> 34
cggaatttgt acatcaccgc t 21
<210> 35
<211> 20
<212> DNA
<213> PCR primer sequences
<400> 35
cttgatacgc aggaccaagc 20
Claims (7)
- 대장균에 대한 항균 활성을 갖고 서열번호 1부터 25까지 모두를 포함하는 부분서열을 가지는 유전체를 가지며 자연으로부터 분리된 박테리오파지 EK88P-1.
- 제1항에 있어서, 상기 박테리오파지 EK88P-1은 기탁번호 KCTC 12574BP인 것을 특징으로 하는 박테리오파지 EK88P-1.
- 대장균에 대한 항균 활성을 갖고 서열번호 1부터 25까지 모두를 포함하는 부분서열을 가지는 유전체를 가지며 자연으로부터 분리된 박테리오파지 EK88P-1을 유효성분으로 포함하는 대장균의 감염 방지 및 처치용 조성물.
- 제3항에 있어서, 상기 박테리오파지 EK88P-1은 기탁번호 KCTC 12574BP인 것을 특징으로 하는 대장균의 감염 방지 및 처치용 조성물.
- 제3항 또는 제4항에 있어서, 상기 조성물은 사료첨가제, 음수첨가제, 또는 소독제인 것을 특징으로 하는 대장균의 감염 방지 및 처치용 조성물.
- 제3항 또는 제4항에 의한 대장균의 감염 방지 및 처치용 조성물을 인간을 제외한 동물에 투여 또는 처치하는 단계를 포함하는, 대장균에 의한 감염을 방지 또는 처치하는 방법.
- 제6항에 있어서, 상기 조성물이 사료첨가제, 음수첨가제, 또는 소독제 형태로 인간을 제외한 동물에 투여 또는 처치되는 것을 특징으로 하는 대장균에 의한 감염을 방지 또는 처치하는 방법.
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CN201510226544.4A CN105176932B (zh) | 2014-05-07 | 2015-05-06 | 利用对大肠杆菌具有广泛抗菌活性的噬菌体防止及处理大肠杆菌感染的方法 |
US14/706,325 US9433653B2 (en) | 2014-05-07 | 2015-05-07 | Method for prevention and treatment of Escherichia coli infections using a bacteriophage with broad antibacterial spectrum against Escherichia coli |
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