KR102418861B1 - 포도상구균에 대한 사멸능을 갖는 박테리오파지 - Google Patents
포도상구균에 대한 사멸능을 갖는 박테리오파지 Download PDFInfo
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Abstract
본 발명은 포도상구균에 대한 사멸능을 갖는 박테리오파지에 관한 것으로서, 더욱 상세하게는 인간, 동물 등의 피부에 감염을 일으키는 황색포도상구균에 대하여 사멸능을 갖는 박테리오파지 SAP27에 관한 것이다.
본 발명에 따른 박테리오파지 SAP27은 병원성 세균인 황색포도상구균에 대하여 우수한 사멸능을 갖고 있으므로, 황색포도상구균이 주원인이 되는 감염성 질환의 예방 및 치료제, 항생제, 소독제 등으로 광범위하게 사용될 수 있다.
본 발명에 따른 박테리오파지 SAP27은 병원성 세균인 황색포도상구균에 대하여 우수한 사멸능을 갖고 있으므로, 황색포도상구균이 주원인이 되는 감염성 질환의 예방 및 치료제, 항생제, 소독제 등으로 광범위하게 사용될 수 있다.
Description
본 발명은 포도상구균에 대한 사멸능을 갖는 박테리오파지에 관한 것으로서, 더욱 상세하게는 인간, 동물 등의 피부에 감염을 일으키는 황색포도상구균에 대하여 사멸능을 갖는 박테리오파지 SAP27에 관한 것이다.
박테리오파지는 세균을 감염시킬 수 있는 바이러스 유사 물질로 알려져 있다. 박테리오파지는 유전물질을 감싸고 있는 외부 단백질 코트로 이루어져 있으며 유전물질은 DNA 또는 RNA가 될 수 있다. 생존을 위해 숙주 세균을 필요로 하며 모든 세균은 대상 파지를 가지고 있다고 알려져 있다.
박테리오파지는 1915년 Twort에 의해 처음 발견되었으며 1917년 d'Herelle이 Shigella dysenteriae 균에 감염된 환자의 검체의 여과액에서 분리하여 처음 Phage 분리하게 되었다.
황색포도상구균은 병원내 감염을 일으키는 대표적인 세균으로 정상인이나 환경에서도 쉽게 발견되는 상재세균이다. 이 세균은 상처나 면역저하환자, 그리고 외과적 치료부위에 오염된 의료기구 등을 통하여 감염하여 항균제로 치료하기 어려운 내성을 가지고 화농성 질환을 일으킨다. 특히 항생제 저항 황색포도상구균(Methicillin resistance Staphylococcus aureus)의 경우 항생제 저항으로 인해 감염환자 치료를 어렵게 하며 바이오필름 등 을 형성하여 치료를 어렵게 한다.
일반적으로 아토피환자의 50~100%는 병변 부위에 황색포도상구균이 상재하고 있기에, 황색포도상구균은 아토피의 대표적인 원인균으로 지목되고 있다. 피부염 환자의 황색포도상구균의 존재는 염증반응을 악화시키며 다양한 침투감염의 위험을 증가시켜 균혈증, 패혈증, 골수염 등이 수반될 수 있다.
황색포도상구균은 피부표면에서 생존하며 진피층까지 침투가 가능하여 면역세포와 직접 접촉하여 Proinflammatory cytokines의 생산을 유도한다. 또한 황색포도상구균은 다양한 타입의 독소를 분비하여 아토피 증상을 악화시킨다는 보고가 있다.
아토피 환자 피부에 존재하는 황색포도상구균을 제어하기 위한 다양한 시도가 이어져 오고 있는데, 한국등록특허 제2314731호는 황색포도상구균에 대한 높은 사멸 능력을 가진 재조합 엔도라이신을 개시하였고, 한국공개특허 제2020-0126262호는 황색포도상구균 특이적 억제를 통해 아토피 피부염을 개선하는 알파-비니페린 함유 아토피 피부염 개선 조성물을 개시하였으며, 한국등록특허 제1723089호는 시코닌을 포함하는 항생제 내성 황색포도상구균 억제용 항균 조성물을 개시하였다. 하지만, 항생제 처리는 슈퍼박테리아를 유도하는 문제가 있으며, Sodium hypochlorite 같은 염소 소독제에 처리는 피부에 존재하는 황색포도상구균 뿐만 아니라 공생하는 여러 세균도 함께 사멸하게 되어 피부 상재균의 다양성에 악영향을 줄 수 있다.
따라서, 기존 항생제를 대체할 수 있는 물질 또는 항생제 내성 세균제어 방법의 개발이 요구되고 있으며, 이에 대한 연구가 시급한 실정이다.
이에, 본 발명자들은 상기 종래기술들의 문제점을 해결하기 위해 노력한 결과, 하수처리장 시료에서 분리한 박테리오파지가 인체 피부 유래 및 환경에서 유래한 다양한 황색포도상구균 및 포도상구균에 대한 우수한 생육 억제능을 갖는다는 것을 확인하고, 본 발명을 완성하게 되었다.
본 발명의 목적은 인간을 포함한 동물의 감염성 질환의 주된 원인균인 황색포도상구균 및 포도상구균에 대하여 특이적인 사멸능을 갖는 신규 박테리오파지를 제공하는데 있다.
본 발명의 다른 목적은 황색포도상구균 및 포도상구균에 의해 유발되는 질환의 치료용 약학적 조성물을 제공하는데 있다.
본 발명의 또 다른 목적은 황색포도상구균 및 포도상구균에 특이적인 사멸능을 갖는 항생제 및 소독제를 제공하는데 있다.
상기 목적을 달성하기 위하여, 본 발명은 황색포도상구균에 대한 사멸능을 갖고, 서열번호 1로 표시되는 전장 유전체를 갖는 것을 특징으로 하는 시포비리대 과(Siphoviridae)의 박테리오파지(Bacteriophage) SAP27을 제공한다.
본 발명에 있어서, 상기 박테리오파지는 기탁번호 KCTC 14076BP의 박테리오파지인 것을 특징으로 한다.
본 발명에 있어서, 상기 박테리오파지 SAP27은 황색포도상구균(Staphylococcus aureus), 스타필로코쿠스 카프래(Staphylococcus caprae), 스타필로코쿠스 페트라시(Staphylococcus petrasii), 스타필로코쿠스 호르미니스(Staphylococcus horminis), 스타필로코쿠스 루그더넨시스(Staphylococcus lugdunensis), 스타필로코쿠스 해모라이티쿠스(Staphylococcus haemolyticus), 스타필로코쿠스 워네리(Staphylococcus warneri), 스타필로코쿠스 자이로서스(Staphylococcus xylosus) 및 스타필로코쿠스 에피더미디스(Staphylococcus epidermidis)로 구성된 군에서 선택된 1종 이상의 균주에 대한 사멸능을 갖는 것을 특징으로 한다.
본 발명은 또한, 상기 박테리오파지 SAP27를 유효성분으로 포함하는, 황색포도상구균 또는 포도상구균 유발성 질환의 치료용 약학적 조성물을 제공한다.
본 발명에 있어서, 상기 황색포도상구균 유발성 질환은 염증성 질환이고, 포도상구균 유발성 질환은 아토피 피부염, 지루성 피부염, 주사, 건선, 건성, 비염 및 액취증으로 구성된 군에서 선택되는 것을 특징으로 한다.
본 발명은 또한, 상기 박테리오파지 SAP27을 포함하는 항생제를 제공한다.
본 발명은 또한, 상기 박테리오파지 SAP27을 포함하는 소독제를 제공한다.
본 발명에 따른 박테리오파지 SAP27은 병원성 세균인 황색포도상구균에 대하여 우수한 사멸능을 갖고 있으므로, 황색포도상구균이 주원인이 되는 감염성 질환의 예방 및 치료제, 항생제, 소독제 등으로 광범위하게 사용될 수 있다.
도 1은 본 발명의 일 실시예에 따라 분리된 박테리오파지의 황색포도상구균에 대한 Spot assay 결과를 나타낸 사진이다.
도 2는 박테리오파지 SAP27의 황색포도상구균에 대한 용균력을 확인한 결과이다.
도 3은 박테리오파지 SAP27의 형태를 전자현미경으로 촬영한 사진이다.
도 4 내지 도 8은 본 발명의 일 실시예에 따라 제조된 박테리오파지 SAP27 조성물의 아토피 피부염 환자에 대한 치료 효과를 확인한 사진이다.
도 2는 박테리오파지 SAP27의 황색포도상구균에 대한 용균력을 확인한 결과이다.
도 3은 박테리오파지 SAP27의 형태를 전자현미경으로 촬영한 사진이다.
도 4 내지 도 8은 본 발명의 일 실시예에 따라 제조된 박테리오파지 SAP27 조성물의 아토피 피부염 환자에 대한 치료 효과를 확인한 사진이다.
본 발명에서는 황색포도상구균에 대하여 특이적인 사멸능을 갖는 박테리오파지를 하수처리장 시료에서 분리하고, 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 공지된 박테리오파지와 유전자 서열이 상이하다는 것을 확인하였다. 또한, 분리된 박테리오파지는 황색포도상구균 뿐만 아니라, 포도상구균에 대하여 특이적인 사멸능을 갖는다는 것을 확인하였다.
따라서, 본 발명은 일 관점에서, 황색포도상구균에 대한 사멸능을 갖고, 서열번호 1로 표시되는 전장 유전체를 갖는 것을 특징으로 하는 시포비리대 과(Siphoviridae)의 박테리오파지(Bacteriophage) SAP27에 관한 것이다.
본 발명의 박테리오파지는 서열번호 1의 염기 서열로 표시되는 유전체를 가진다.
황색포도상구균은 피부감염, 식중독 등을 일으키는 주요 원인균이고, 국내에서 조사된 항생제 메티실린에 대한 내성률이 평균 73%로 세계 최고 수준인 매우 위해한 병원균이다. 이는 항생제를 써도 죽지 않는 황색포도상구균이 73%가 된다는 뜻으로 내성이 매우 강한 병원균이라고 할 수 있다.
본 발명에서는 하수처리장에서 얻은 하수처리 시료로부터 황색포도상구균에 대한 사멸능을 갖는 박테리오파지를 선별하였고 이를 “staphylococcus aureus phage-SAP27”로 명명(약칭: 박테리오파지 SAP27)하였다. 또한, 선별된 박테리오파지를 2019년 12월 13일자로 한국생명공학연구원 생물자원센터 (기탁번호 KCTC 14076BP)에 기탁하였다.
본 발명은 선별된 박테리오파지 SAP27 유전체의 핵산 분자 서열을 제공한다 (서열번호 1).
본 발명에서 사용된 "핵산 분자"라는 용어는 DNA (gDNA 및 cDNA) 그리고 RNA 분자를 포괄적으로 포함하는 의미를 가지며, 핵산 분자에서 기본 구성 단위인 뉴클레오타이드는 자연의 뉴클레오타이드 뿐만 아니라, 당 또는 염기 부위가 변형된 유사체(analogue)도 포함한다(Scheit, Nucleotide Analogs, John Wiley, New York(1980); Uhlman 및 Peyman, Chemical Reviews, 90:543-584(1990)).
본 발명에 있어서, 박테리오파지 SAP27은 황색포도상구균(Staphylococcus aureus) 뿐만 아니라 스타필로코쿠스 카프래(Staphylococcus caprae), 스타필로코쿠스 페트라시(Staphylococcus petrasii), 스타필로코쿠스 호르미니스(Staphylococcus horminis), 스타필로코쿠스 루그더넨시스(Staphylococcus lugdunensis), 스타필로코쿠스 해모라이티쿠스(Staphylococcus haemolyticus), 스타필로코쿠스 워네리(Staphylococcus warneri), 스타필로코쿠스 자이로서스(Staphylococcus xylosus), 스타필로코쿠스 에피더미디스(Staphylococcus epidermidis) 등의 포도상구균에 대하여 특이적인 사멸능을 갖는 것을 특징으로 한다.
한편, 박테리오파지 SAP27은 피부 유익균으로 알려진 락토바실러스 종, 류코노스톡 종, 와이셀라 종 등의 유산균에 대해서는 항균활성을 갖지 않는 것을 특징으로 한다.
상기 락토바실러스 종으로는 락토바실러스 루테리(Lactobacillus reuteri), 락토바실러스 플란타럼(Lactobacillus plantarum), 락토바실러스 브레비스(Lactobacillus brevis), 락토바실러스 사케이(Lactobacillus sakei) 등을 예시할 수 있고, 류코노스톡 종은 류코노스톡 시트레움(Leuconostoc citreum), 류코노스톡메센테로이데스(Leuconostoc mesenteroides), 류코노스톡 락티스(Leuconostoc lactis) 등을 예시할 수 있고, 와이셀라 종은 와이셀라 시바리아(Weissella cibaria), 와이셀라 김치(Weissella kimchii), 와이셀라 코린시스(Weissella koreensis), 와이셀라 콘퓨사(Weissella confusa) 등을 예시할 수 있다.
본 발명은 다른 관점에서 박테리오파지 SAP27를 유효성분으로 포함하는, 황색포도상구균 또는 포도상구균 유발성 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.
본 발명의 조성물에 포함되는 박테리오파지는 일반 항균제보다 내성세균 출현의 문제가 적고, 세균에만 용균작용을 나타낼 뿐 진핵세포에는 작용하지 않는 선택적 독성이 우수하므로 인체와 동물에 무해하기 때문에 감염병 치료에 이용될 수 있다.
본 명세서에서 사용된 '치료'라는 용어는 황색포도상구균 또는 포도상구균에 의해 유발된 질환의 예방; 황색포도상구균 또는 포도상구균에 의해 유발된 질환의 억제; 및 황색포도상구균 또는 포도상구균에 의해 유발된 질환의 경감을 의미한다.
상기 황색포도상구균 유발성 질환은 유방염, 아토피 피부염, 패혈증, 화농성 질환, 식중독, 폐렴, 골수염, 농가진, 균혈증, 심내막염, 장염 등의 염증성 질환을 예시할 수 있고, 포도상구균 유발성 질환은 아토피 피부염, 지루성 피부염, 주사, 건선, 건성, 비염 등의 염증성 질환과 액취증을 예시할 수 있으나, 이에 한정되는 것은 아니다.
본 발명의 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다. 본 발명의 조성물에 포함되는 약학적으로 허용되는 담체는 제제시에 통상적으로 이용되는 것으로서, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산 칼슘, 알기네이트, 젤라틴, 규산 칼슘, 미세결정성 셀룰로스, 폴리비닐피롤리돈, 셀룰로스, 물, 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘, 미네랄 오일 등을 예시할 수 있으나, 이에 한정되는 것은 아니다.
본 발명의 약학적 조성물은 상기 성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥내 투여, 복강내 투여, 근육내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사는 소망하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다. 일반적으로, 본 발명의 약학적 조성물은 1×103 내지 1×1010pfu/㎖의 박테리오파지를 포함한다.
본 발명의 약학적 조성물은 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 약학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화 됨으로써 단위 용량 형태로 제조되거나 또는 다용량 용기내에 내입시켜 제조될 수 있다. 이때 제형은 오일 또는 수성 매질중의 용액, 현탁액 또는 유화액 형태이거나 엑스제, 분말제, 과립제, 정제 또는 캅셀제 형태일 수도 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수 있다.
본 발명은 또 다른 관점에서 박테리오파지 SAP27을 포함하는 항생제에 관한 것이다. 본 발명에 따른 항생제는 화장품용 및 의약품용으로 이용될 수 있다.
본 발명의 박테리오파지 SAP27은 황색포도상구균에 대한 우수한 사멸능을 가질 뿐만 아니라, 아토피 병변부위에 바이오필름을 형성하여 증상을 악화시키는 것으로 알려진 포도상구균에 대해서도 사멸능을 갖지만, 피부 유익균인 유산균에 대해서는 사멸능을 갖지 않는 장점이 있다.
본 발명의 박테리오파지를 항생제로 이용하게 되면 기존의 항생제를 이용하는 것과는 달리 황색포도상구균의 내성 내지 저항성(resistance)을 유도하지 않는다는 중요한 장점을 갖기 때문에 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 제공될 수 있다. 대부분의 항생 물질들은 내성 증가에 직면함에 따라 갈수록 사용범위가 줄어들 수밖에 없는데 반해, 본 발명의 박테리오파지를 유효성분으로 포함하는 항생제는 항생제 내성 문제를 근본적으로 해결할 수 있기에 그 만큼 항생제로서의 제품수명이 길어질 것으로 기대된다.
따라서 황색포도상구균을 사멸시키는 본 발명의 박테리오파지를 유효성분으로 포함하는 항생제는 항균 효과, 살균 효과 및 방부 효과가 뛰어난 항생제로서 유용하게 사용될 수 있다. 본 명세서에서 사용된 '항생제'라는 용어는 방부제, 살균제 및 항균제를 총칭한다.
본 발명의 또 다른 관점에서, 박테리오파지 SAP27을 유효성분으로 포함하는 소독제에 관한 것이다.
본 발명에 따른 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 또한, 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 축산산업의 축사 소독제로서 유용하게 사용될 수 있다.
또한 본 발명의 소독제에 사용되는 박테리오파지는 자연 분해되므로 친환경적이고 액상으로 준비 가능하기 때문에 일반 환경 또는 의료 기구에 존재하는 황색포도상구균을 제가하기 위한 소독제의 용도로서 매우 유용하다.
[실시예]
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.
실시예 1: SAP27 박테리오파지의 분리 및 동정
경기도 소재 하수처리장으로부터 얻은 하수처리 시료 50ml를 원심분리(3000 Xg, 15분, 4 ℃)하여 세균 및 큰 입자를 제거하였다. 상등액을 0.2 ㎛ Pore size membrane filter를 이용하여 제균한 이후 4 ℃에 7일간 보관하여 불안정한 박테리오파지를 제외시켰다.
박테리오파지의 존재유무를 확인하기 위해 Host 균인 황색포도상구균 KCTC 1621를 Luria bertani broth w/CaCl2 10mM의 배지에 접종하고, 35 ℃에서 24시간을 배양하였다.
제균이 완료된 분리 시료 100 ul와 증균된 황색포도상구균 100 ul을 Soft agar(Luria-bertani agar(0.5%) w/CaCl2 10 mM)에 넣고 혼합한 후 Luria-bertani agar 위에 분주하여 굳힌 뒤 35 ℃에서, 24시간을 배양하여 Plaque 형성유무를 관찰하였다.
형성된 Plaque를 따로 취하여 SM buffer (10 mM MgSO4, 100 mM NaCl, 0.01% gelatin, 50 mM Tris-HCl, pH 7.5)에 현탁하여 단일 파지집락을 선택하였다 (도 1).
선택된 단일 박테리오파지를 생명공학연구원의 유전자은행(KCTC)에 기탁하고 (KCTC 14076BP) "staphylococcus aureus phage-SAP27"로 명명하고, 본 명세서에서는 약칭인 '박테리오파지 SAP27'로 기재하였다.
실시예 2: 포도상구균에 대한 Plaque 형성
실시예 1에서 얻은 황색포도상구균 저해 파지 Plaque의 항균활성을 확인한 결과, 총 84주의 황색포도상구균 종에 대해 항균활성을 보이며, 포도상구균 17종, Staphylococcus caprae 3종, Staphylococcus petrasii 1종, Staphylococcus hominis 2종, Staphylococcus lugdunensis 3종, Staphylococcus warneri 2종, Staphylococcus xylosus 2종, Staphylococcus epidermidis 4종에 대해서 항균활성을 보였다.
실시예 3: 박테리오파지 SAP27의 황색포도상구균에 대한 용균력 확인
박테리오파지 SAP27의 황색포도상구균에 대한 용균 활성능을 확인하였다. 황색포도상구균 KCTC 1621균을 Luria Bertani broth + 10mM CaCl2 배지 10 ml에 접종한 후 35 ℃에서, 24시간 배양하여 Seed culture를 준비하였다.
테스트군과 대조군으로 각각 500ml 삼각플라스크에 Luria Bertani broth + 10 mM CaCl2 배지를 100ml 준비한 후 Seed culture 1ml를 접종한 후 OD600 흡광도를 측정하였다. 2시간 배양 이후 테스트 군에는 박테리오파지 SAP27 (2×109 PFU/ml) 0.1 ml을 접종하고, 8시간동안 배양하면서 흡광도를 측정하고, 그 결과를 도 2에 나타내었다. 도 2로부터 박테리오파지 SAP27를 처리한 테스트 군에서는 황색포도상구균의 성장을 관찰할 수 없었으며, 용균활성이 지속됨을 확인할 수 있었다.
실시예 4: 박테리오파지 SAP27의 형태관찰 및 분류
박테리오파지 SAP27의 형태관찰을 위해 박테리오파지를 PEG 정제하고, Plaque assay법을 이용해서 박테리오 파지의 농도를 측정하여 2×109pfu/ml의 농축액을 분리 정제하였다. 박테리오파지 solution을 Copper grid에 올리고 2% 우라닐 아세테이트(Uranyl acetate)로 염색하고 건조하였다. 염색된 시료를 80 KV의 전압으로 에너지 여과 투과 전자현미경 (Hitachi, H-7600)을 이용하여 관찰하였다.
도 3에 도시된 바와 같이, 박테리오파지를 형태적으로 분류하였을 때 비교적 둥근 Capsid head와 Flexible하고 긴 sheath와 말단 spike를 보이므로 시포비리데(Siphoviridae)에 속하는 것으로 판단하였다. 머리의 길이는 약 95.21 nm 이고 sheath의 길이는 약 210.34 nm이다.
실시예 5: 박테리오파지 SAP27의 유전학적 특성
박테리오파지 전체유전자 염기서열분석을 위해 DNeasy Blood&Tissue kit(Qiagen)를 이용해서 전체 유전자를 추출하여 준비하였다. 전체 염기서열 분석을 위해 ㈜마크로젠에 의뢰하였다. 염기서열 분석결과 전체 염기의 개수는 142,661 base pairs이며 GC 함량은 30.2 % 이었고, 219개의 ORF로 구성되었다.
전체 염기서열을 미국 NCBI의 Blast 검색을 한 결과 SAP27파지의 게놈은 기존 황색포도상구균 파지인 GCA_003328845.1_S.phage_SA3_와 93.5 % Query coverage를 나타내며 가장 가까운 파지로 나타났다.
실시예 6: 황색포도상구균 및 포도상구균에 대한 항균활성 및 유산균에 대한 감수성 조사
황색포도상구균에 대한 박테리오파지 SAP27이 갖는 숙주균에 대한 항균활성을 조사하였다. 숙주별 감수성은 해당 숙주로 사용되는 황색포도상구균 및 포도상구균을 10mM CaCl2가 첨가된 Luria-bertani broth에 접종한 후 35 ℃, 24시간 배양한 균을 10 mM CaCl2가 첨가된 Luria-bertani agar에 접종하여 Lawn을 준비하였다. 유산균의 경우 유산균을 배양하는 MRS agar 배지에 각 유산균의 lawn을 준비하였다. 준비된 배지에 각각 박테리오파지 SAP27을 107pfu/ml로 준비한 용액 10ul를 떨어뜨려 plaque의 형성 유무를 관찰하였다.
또한, 일반적으로 피부에 유익균으로 알려진 유산균에 대한 항균활성도 함께 조사하고, 그 결과를 아래 표 1에 나타내었다.
| 균주 | 항균 활성 | 균주 | 항균활성 |
| S. aureus KCTC 1621 | +++ | S. epidermidis MGSE3 (인체분리균) | +++ |
| S. aureus KCCM 12103 | +++ | S. epidermidis MGSE4 (인체분리균) | +++ |
| S. aureus ATCC 13565_SEA | +++ | Lactobacillus reuteri | - |
| S. aureus ATCC 23235_SED | +++ | Lactobacillus plantarum | - |
| S. aureus ATCC 19095_SEC | +++ | Lactobacillus plantarum | - |
| S. aureus ATCC 14458_SEB | +++ | Lactobacillus brevis | - |
| S. aureus ATCC 27664_SEE | +++ | Lactobacillus sakei | - |
| S. aureus ATCC 6538 | +++ | Lactobacillus sakei D501 | - |
| S. aureus ATCC 3881 | +++ | Lactobacillus sakei D520 | - |
| S. aureus RN4220 | +++ | Weissella cibaria | - |
| S. aureus Newman | ++ | Weissella cibaria | - |
| S. aureus 35종 (식품 유래 분리균) | +++ | Weissella cibaria B005 | - |
| S. aureus MGSA1 (화장품 제조실 분리균) |
+++ | Weissella cibaria B248 | - |
| S. aureus MGSA2 (화장품 제조실 분리균) |
+++ | Weissella kimchii | - |
| S aureus 29종 (국립수의유전자원센터 분양균) |
+++ | Weissella koreensis | - |
| S. caprae ATCC35538 | +++ | Weissella confusa | - |
| S. caprae MGSC1 (화장품 제조실 분리균) |
+++ | Weissella confusa | - |
| S. caprae MGSC2 (화장품 제조실 분리균) |
+++ | Leuconostoc citreum | - |
| S. petrasii (화장품 제조실 분리균) | +++ | Leuconostoc citreum | - |
| S. horminis J2 (인체분리균) | +++ | Leuconostoc mesenteroides | - |
| S. horminis J1(인체분리균) | +++ | Leuconostoc lactis | - |
| S. lugdunensis 1 (화장품 제조실 분리균) |
+++ | Leuconostoc lactis D101 | - |
| S. haemolyticus 2 (화장품 제조실 분리균) |
++ | Leuconostoc lactis D121 | - |
| S. warneri ATCC11224 (인체분리균) | +++ | Leuconostoc citreum B093 | - |
| S. xylosus MGAJNZT01 (화장품 제조실 분리균) |
+++ | Leuconostoc citreum D340 | - |
| S. epidermidis MGSE1 (인체분리균) | +++ | Lactococcus lactis | - |
| S. epidermidis MGSE2 (인체분리균) | +++ |
표 1에 나타난 바와 같이, 박테리오파지 SAP27은 표준균주를 포함한 인체피부, 식품, 축산 유래의 황색포도상구균(S. aureus)에 대하여 항균활성을 보였으며, 기타 인체, 화장품 제조원료 및 환경 유래의 포도상구균(Staphylococcus sp.)에 대해서도 항균활성을 나타내었다.
이 중 S. horminis균은 인체 액취증을 유발하는 세균으로 알려져 있으며, S. warneri, S. epidermidis 등의 균은 정상적인 경우 S. aureus와 대사에 있어 경쟁을 하면서 황색포도상구균을 억제한다고 알려져 있지만, 아토피 병변부위에 바이오필름을 형성하여 증상을 악화시키는 것으로 알려져 있다.
한편, 박테리오파지 SAP27은 피부에 상재하면서 황색포도상구균에 대한 항균활성을 갖고, 유해균에 대하여 경쟁적인 유익균으로 알려져 있는 유산균에 대해서는 항균활성을 갖지 않는다는 것을 알 수 있었다. 따라서, 박테리오파지 SAP27은 향후 피부 보호용으로 유산균을 사용할 때 영향을 주지 않을 것으로 예측된다.
실시예 7: 아토피 피부염에 대한 효과 검증
황색포도상구균 및 일부 포도상구균은 아토피 피부염의 유발과 병증의 악화를 야기하는 것으로 알려져 있다. 실시예 6에서 확인한 바와 같이, 박테리오파지 SAP27은 황색포도상구균 및 포도상구균에 대한 항균활성을 갖고 있으므로, 이는 아토피 환자에게 처리시 아토피염 치료 효과가 있을 것으로 예측되었다.
따라서, 아토피 피부염으로 판정된 성인 남자 5명을 대상으로 박테리오파지 SAP27을 포함하는 조성물을 제조하여 그 효과를 평가하였다.
조성물의 구성은 박테리오파지 SAP27 106PFU/ml, CaCl2 10mM, 20mM Tris-Cl(pH7.5), 100mM NaCl, 60mM MgSO4·7H2O, 0.01% gelatin으로 구성하였다.
박테리오파지 SAP27의 자체 효과를 검증하기 위하여, 피부 보습제, 방부제, 유연제 등의 화장품 기본 구성을 이루는 성분을 제외시키고, 기본 버퍼 조성을 제조하였다.
팔 안쪽, 발목, 팔꿈치 뒤, 복부 및 손목 병변 부위 각각에 박테리오파지 SAP27 조성물을 오전 9시 및 저녁 9시 하루 2회 도포한 후 건조시켰으며, 해당 부위에는 기타 보습제, 화장로션 등을 처리하지 않았다.
치료 효과를 확인하기 위하여, 매일 결과를 확인하고, 그 결과를 도 4~도 8에 나타내었다.
평가 결과, 처리 전 아토피 병변 부위에 있던 가려움증이 처리 후 30분 이내 개선되었으며 처리 후 1~2일 후에는 염증부위가 가라앉으면서 서서히 병변 부위가 사라지는 것을 확인하였다. 또한 복부 병변부위는 염증반응 초기단계 붉어지는 부위에 도포하였을 경우 염증반응이 줄어들어 회복속도가 매우 빨라짐을 관찰 할 수 있었다.
이상으로 본 발명 내용의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적 기술은 단지 바람직한 실시 양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다고 할 것이다.
SEQUENCE LISTING
<110> Microgiene Co., ltd
<120> Bacteriophage with growth inhibition activity against
Staphylococcus sp.
<130> P21112
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 142661
<212> DNA
<213> Bacteriophage SAP27
<220>
<221> misc_feature
<222> (58658)..(58667)
<223> n is a, c, g, or t
<400> 1
tgttattgcc atttaaaatc actccttatt tgttatgtac taatcatatc atagtaagtc 60
atatttgtca acaaaaaaag aagaactttt taaagttctt ctaaatgagt ttcgtatata 120
accttttgaa ttttatttag tggttctaaa tctaaattcc taataagttt ttcgtatttt 180
cttgagttct tgaagttaat agtattaggc atagcaagag cttcatcaac gtctttagta 240
tagcttacaa catctgaata gatatctact tcttttacat atagaccttg agttaaactt 300
ctaaatacta cctcattatg tgctataact tcttctttct tttctatgct catttgtaaa 360
cctcctggtt tattctacac aaacaagtac gtactctaag ctagttaatg atactgattt 420
aatattattt aattcttgca atttcttaat atctacatca tagtttttac ttatagtcca 480
taatgtctct cctgctctta ctttatggta atacttattc ccctctttaa taaggtcatc 540
caatattacc tacctccttg agtaataatt agcctgtaga taacatataa gtataagaac 600
aaagtttaca aattcagtag ctataatatg aacataggta tgtgataaaa ccatacttac 660
tatcaacgaa gctaatccta atccaataat aaggaataga aatctgtttg tcccttctga 720
acttttagtt ttataaaatg ttgttatctg agttacatac gcaaggataa tagtaatagt 780
tgctacagtt tgtgttaagg ctgtaaagtc acttaataaa aacagtaaca atgagaacac 840
aataataaaa ggtatagaga aataatcctt ttttctatat gaagctacta ataagcaaac 900
aatacctaga gttaaattaa gaccaactga tactacttga aacattgtag catcagttaa 960
tagtaaattg taaaaactaa tacctactgt agctacaatt aaataccaaa aataactact 1020
aactccttta acactatccg atttaactaa agctattaga cccggtatat aacctactgt 1080
aactaatata gcatataata tactcaagta atgtgataaa ttatccatct tgttctccta 1140
atttctctaa tctttctaaa acttcttccc aagagataaa tccttctcca ttggtcaggc 1200
ttagcacaca tccgtagata aactggttcg tactaaattc agctctatca gggtcatcat 1260
aaccttttcc atgtccttgt cgaatatccg agcaataaat taaaacaggt ttatttaaaa 1320
tattttcaag tttttctacg attaattcct cttcttcact taaccaagtt tcaaatctat 1380
ctgatatata attaaagtgt tcttctccat tatcatatat atggttaata gtttcttgtg 1440
cttgatgctt catacctagt aaaataccaa gttctgcaat cgttcctagc ccctcattaa 1500
gtatatcaaa cacaaatata tctgagtctt gcatagcttt aaagtcattg tttaaaatgc 1560
gctctgctaa accagtttgt tctgcattag ccttatcatt aattgattta tctttatgag 1620
ggctgtaagg agtgactcct acaatacttt ctacttgctt atgctgtttg tctctatatt 1680
ctaccattgc atcatttaaa atatgtccac ccatataaat tactttgtct ttaatataat 1740
taaccattta tagtatctcc tttttcttct agaatacctc ttaaaacgtg tggcatcttt 1800
ttcttaattt gtttttctat aattttcatc atattttctt tttcttcttc cataatatca 1860
tcaacaaaat tttgacctac ttgtttcata attaaaccaa aattttctaa ttctaaatca 1920
tcttcagaca atctgttttc ttctatagct ctaaaaatca ttttttccat tcttgatttt 1980
gtgatagcat aatctgccac agaatcatta cttctaactt ctgatttcat tttcttacga 2040
ctaaactctt taaattcctt agatactaat ttaaagtaat catcatgttc tgacttacca 2100
tctaaatatt taataacaat accttctcct gtattaggtt taacagtcat atctgattgt 2160
cctactaaat cttgaatttc ttgagggttt aatccattaa gataaaaaga tggttctaca 2220
atcattaaag tttttacagt tttcaaacct aatgtttctg ataaagaaat gacttctgaa 2280
tgaggtaagt aggtttcact atccttatcg tatacatcga atacataaaa attattataa 2340
caatcttctt tataatttac cttatgttta actaaccatt ctccaaatat aataatacct 2400
tctaatatag ataaatctaa cttatctgtc atgttttcat gtacccaatt ataaaaaccg 2460
tttaatgttt cgttttcatt taattttttt ctacgagaga aacagactaa ctcaccattc 2520
tctgtagtaa aacttgcgtt gcttccatct aatttttctt gaattacaaa acctctatct 2580
ttaaatttgt ctaaagataa tcctttattt tttactttag tataagattt cattaattag 2640
ttatcctcct ttgaattatg tactattgaa aataaaataa gacttacact tgataaaaat 2700
gctaatacca ctaaaccagg taaatttaga actgttgata agaataatga tattgcactt 2760
ataatataaa ctaaaccgct tagaaataaa gttaataata caattgttat aagctttacc 2820
aaccaattat tattaataaa taccttagct aaataattca taaaaaatcc tccttagtta 2880
ttataaagta agtataccat aactaaagag gtttgtcaac atattatttt accatttaaa 2940
attgtctgca tactgagcta acttagaacg gaaattaact gtaaaattat ggaataccgc 3000
accatcataa tttttaaaat attccatata atctccaaaa cctgatttac tttcattttt 3060
taaatctatt tgcttgaaat ttccttcaac tattactgta gaattttttg tatgaatcct 3120
tgtaagtact ttcttaagtt cacttcgttt aaagttttgt gcttcattta taattatagt 3180
agcatccctt aaattaccgc ctcttaaaaa taaatgtgat atttgggata cccaacattc 3240
acctaattta tcttctttga cattatcttc catcattaac atttcggtta tttgttgttc 3300
aggactcata ttaagttcaa taagggcatc atgtaatccc atgaaataag ccatttcttt 3360
ttctgtttgg ttaccaggtc tactacctaa atcttctgat acaggtgaaa ttacaaatac 3420
taattttctg ttcttattta gataatcagc ataagcacaa gctactgaac acattgtttt 3480
acctgtaccg gcttgacttt cattccaaag tatttcaaca ttatcattaa agaaatcctc 3540
acagaaatct aattgctcag ttgtagcttt ttcaaggaat tcattgaata ctagatgttc 3600
tcccatgtta tatcttacat taggataatc ttttaactta aagtctaact cttttagttg 3660
tattgccata ttttaaagtt cccctatcta taaatagttt tactctcttt taatatagta 3720
ctaattacct atatattcac ctgttgaaga acaatagtta ctgcagttac attcaggata 3780
attttcacaa acttcttcat cttcatcatc aaataagtct tcatgataaa tactagaatc 3840
aaaatctaca atacaatttt ctcctttacc tttagatatg cctgtgtaaa taacttcatc 3900
aaccatatcc caatcattac ctactaagta atttacagta tttgatactg aatcattatc 3960
aggtaagtag atatcaccat ctgtaaactt aattaaaata tctccttgag gtaatacatc 4020
attaattaaa tcaatttttg tatcttcttc aatagtaaat acagttccct ctagcttttc 4080
aggagtagta tgtgttaaat gtttaacatc ttctcctgat tcttcataaa atccgactgc 4140
attcatttcc ttgttatact ttgcaataaa tttaccatta tcactgacta aatattgact 4200
gcttgcatta taatcttctg catcttctaa agtcatagat gggttgtggt ctttaacata 4260
gtaactaatc tttctaacat ctgttgtttg aattttcttt ccttcacctt taattactga 4320
attaattttt ttcataatat tttctccttt ttatatatca attgattttt ttgcaagatt 4380
atcagcgtag tcattccatt tatcatttga gtgacttttt acttttacaa agtttatatc 4440
tattactttt tggtattctc gtatcatatt aatatatgtt ttacttagaa tatttcttgc 4500
agaccaagta ccttcatacc aatgtattaa accaatataa tctatataaa ctattgcctg 4560
attgtatcct agttttatag cctcttcgat accgtaacaa caagctaata tttcacctgc 4620
aacattatta tactttatca atcctggttt gtcaacactt ttactaattt ccgctattat 4680
atttccttct ttacttacta agacagcacc tgagcctact ttacctttat tataagatga 4740
gctaccgtct gtgtatatat ttacactatc ctgcatattt ataatcctcc ataaattgag 4800
ggaattcaca atctgaatat acttctctgc agaaagatac tgaaatataa ttaaaatcaa 4860
aacatttgaa acagtgttct tgaacttctt ttttgtcttt agcaatcaca ttaaatttaa 4920
aaccatcagc tattactgta aatactcctt ttttcataaa acaaatacct ccactaattt 4980
tattttaaat taataactaa ctcaataaac gatttaatag ttttattttt accttcatca 5040
atatctgaaa agaaattaat taaactatca tcttcatcaa ataaatcttc aacatcatca 5100
aatttattta atatgtctgt aacactataa ccttcttctg atatatactc atgcaagtct 5160
tctgcatcct ctgacagagt tgcttctatc ttaccattct tactttcaat taaatacaaa 5220
gtatttaata ctttaataga atctattact acactgtaat tactaatagt aggatactct 5280
gtataaagta tttccacatt agtattcata taactatcaa ttacagaatt aactgtgtcc 5340
ctttttaatt cagatacatt atgttttcgt atagtaggga attcttcgtc atattctact 5400
aattcttttc tatctgtatt caataatttg tctaaagaag ataataatac tattttatat 5460
tgattgtccg gtagactatc tgtaatttcc ataatggtta aaaaagtatc ttcacctaaa 5520
actttattta tatcctgtaa ttcaaatgaa tctaccattt caatagtatc atctatatca 5580
tctgtagtca ttaaaaaatt aactaaatta ttattctcca tcgtcttcct ccaattcttt 5640
aaatagctct ttacctggag tatttaacgc tttctctaac ctcattaaat tagcacttct 5700
tggtttcttt ttaccatact cccaataaga tataagagag taatgtaccc ctatctcaga 5760
agctaggctt cttaatgtat gtcctttctc tactctaatt ttttgaagat ttagaggttt 5820
actttccttt ttttcatcca taactatttc tcctctactt ttaaaaattt aaaatcctca 5880
gatgcttttg cattttttag tatatactcg tgtgatttgt ctcttgcctc tgctttactt 5940
ttagcatata actctatata gaatacatga ggttttttta aagatggtga ttcatatctc 6000
caataaactt taaaaagtag tgtttctttt tttagaacat taattctaaa ccatctttta 6060
aatttattca ttcattatcc tcctttattt atttgttaaa ctaattatag catagttaac 6120
ttatgaagtc aactataata tacaaaaaag actaagaaat taatcttagt cttaatatat 6180
taataactat tatgtgcgtt gtggtatgca agagctcctg atgttgaacc gtaacggtca 6240
atcatatatt gttttgcacc tttagtttgt tctgctatag aacccccact ccatgattta 6300
cctaatcctt ggaatagtcc ttgagctcct gatgatgcat taacggcatt aggattcatt 6360
gtagattcac gcatagcaat ttcaatcatt gcctcgtctc cgcctgcttg tctaatttgt 6420
tctgctacag aacctcctgt agaactagtt gattgtgtag gttgtttagt ttctttttga 6480
actggtgctg atgttggttg tacttctttt ttcgtatctt gtttattttg agtatcaaat 6540
tgcgcttgtt gttggtctac tttttgttca ggtgtttgtt cttctcctgc tagtctagat 6600
actgtgttat ctacttgagt tgaacctgag tgatattcgt atccaaaatt accattataa 6660
ttatagaaat gataagtaaa ttctccgtca ctgaatgaga aatcatagtt accttcttga 6720
attggttttg tatttacttc tactgaattt gatttagctt gttctgctaa cttattataa 6780
tcaatttcgt ctgcactagc ttcgtttgta gcaatacctc caaaagtaat agccgtacct 6840
aatgctaatg ttgcaaaaat tgttttcttc ataaatttaa aactccttaa ataatttttt 6900
agaattgttt atttgtaaat cgacataagt aatcataaca tatatcttta aataacgcaa 6960
gtataatata gcactaatta gtgtaatatt attaaagttt tattacaaac attacagtta 7020
tcagataatt aaagacaaaa aaagagaggt attaacctct ctaatttatt atttccctgt 7080
tacgtctacg atagttccgt ctccgccaat ttgaataggt tgtttaccat cccatttttc 7140
aattaactgt tgacgtaata tcttatcaga taaagaagat tctctaatct cattggcttt 7200
tttatcacca ttagcttcta cttctttttt cttagcattt tgttcagcaa tttgtttatc 7260
aactttagta cgttctaact cttggttagc tttaacacgg ctgtcaattg ctttttgagt 7320
attcttatct gctttagggc tagataatgc aatgtcctca attacaaatc cttgtttttc 7380
taagttatca tttaagctat ctaaagtatc ttttttaatt tctcctgtct taacaccaaa 7440
tgcatcaatt acagaatact tagatactgc ttgacggaca ttatcttgta cacgtgaacg 7500
taagtatcct ttttctagtt cttcaatatc tgcactacca aaacgattaa ataaatctac 7560
agctttagtt gcatctactt tataagatac atcaatatcc atttgtaaat ttttgccgtc 7620
tgaagttgct acgtttaaat ctttatactt atgtgtttgt gttttagttg ggtatttatt 7680
tactttatca aaaggcgctg ttagatgcca accaggtgat ttagtatctt ccttaacacc 7740
gtttactgag tatacaactc caacatgacc ttgtggaatc tttgtaatac acattaataa 7800
aataataaat cctataattg ctaaaaatcc taatactcct gaaataacta ctgactttct 7860
cattacattt ctcctttttc tatttctttt attaagctat ttaaagcttt ttcctcttgg 7920
tctatttctt gtttatcggc tctagttaca attgattgtc tacggtcatt taaaaattgt 7980
tttttatact ttacatattg ttctaacccg tattcatcta atgtaccttg cctaactaat 8040
tccctgtatt gttttcttat gttacttttc ttctctttca atgaaagaaa atcgaataca 8100
taacttatac caaaacctac aaggactaga aaaacaataa aaatagcaaa gtatgttaaa 8160
aataatgcca tgtaattcct cctttatttg attacatata taactataca ctatgtattt 8220
aattttgtca acactttttt gcaaaaaaaa tagacggatt taaaatccgt ctaaatttct 8280
attctatttg aatactcccc aagcaacacc aggtacttga ttaggtggaa caccttgaca 8340
agttctaaca ggacaatata ctctgttacc attgtaagca ttataaccta tccaaatgtg 8400
acctgcttgg atacaaactt cgtcatatac aattgtagct cctgccggta agttacctcc 8460
tactggagca tttaagaatg gagaacctat tctagttact ataggttggt taccattaac 8520
aaatgttgca ttttccggtt tgtaccaagt tccgtactgg ttctttttcc aagagcccgt 8580
tactggtcta gttgccggtg tacttgcgct acttgtttta ccatctttaa ctactgtaga 8640
acttgaagtt cctttatcca tgtagttttt aatttgttta atgaaataat cttttagttt 8700
attcattatt gcttgagatg gtcttccttg tgttactgga ttaaatcctg tatgaagaac 8760
catagaacga tgaggacaag ctgttggaac aaattccata tgcaatctta cagttttacg 8820
attaggagta agaccccatt ctttaaattt ctctgcagta aattggaata ctgcttgttc 8880
gtttttaagg aattgagcat cactagcact cattgattga cagacttcaa tacctgcaaa 8940
tctaaagtta cctgagtttg ctcctgttcc atctcctgtg tgccaagcaa tttgattctt 9000
agcatctatt gcttcccata cataaccttc agagccgtag taatgagcaa taccattagc 9060
atatctagca taacctgcgt tagctaatga attctcgtat tgttgccctg aagaacgacc 9120
tgcatcgttg tgtattacca ttccttcagg tttcttacca cgtttatcca ttgtatagtt 9180
aatatggttc ttagaaactt ttagtgttgc tttcttttta ggtgcaggtg ttttacttgc 9240
acttttctta gctgtttctt ttttaacagt agttcctact tttacaggta tctcaataaa 9300
atgagttaat ccgtaataat tatctacacg ttttgtaggt tttttattag cgtaaccgtt 9360
ccagttttgc tctaaaatag taaatgtaga agtattacct ccatcatata caatacctat 9420
atgaccccac tgttgataac taccggatgt aaatacagca atccaacctt ttttaggtac 9480
tgtagaaggt ttattttcat gtattttaaa tccagtacca taactttgtt tgatttggtc 9540
tttagcatta ccccaagttc taactttatt atctgttaac cataatacat aatcagtaat 9600
taaatcttga cactgtgcat gatagtaacc atctgcgtca attgctcctg cttccattac 9660
accaaacgat gggtcatagc ttgtagcttt tttaattcta taaggactgt ctactgtacc 9720
ttttgcataa gcgtctaaac gtttatttat ttctgcttga gtcttagcca ttacttaact 9780
tcctcctctg caaatacttt accgtgttcc tcggtatctt cttcatcttg agaaggtgct 9840
gaaccaccat caatttcatc ttcaatagca ggtacttcat cactatcatc tgtatcaggt 9900
tctgcattgt tttcgtagtt gtctaattcg aaagtgctag ctgtgtttgc atttgcttgc 9960
cattgaacaa attcattagg gtctttacta tcacgaggtt ttatataatc tgtttgaaca 10020
atatcactat ctttaagacc tttagtattg ttatcaacaa taatacctaa acctgctaat 10080
aatgttagta tagaacctac gatattgaca ccttgctcaa tttgagctga gtagtctaaa 10140
ccaaaagcac ctgtaatttg attagcaaat aatgctactg ctgatataat tgctacccaa 10200
aatgttttac tcttagttct tgtgctaagg tttattcctc caacaacttt aggttgttta 10260
gtttcattag ccattaaaaa accgaccttt ctattatatt tatttctaac aataatataa 10320
cagtaggtcg gtcatgttta tctatattaa tttaacactt actcattaat ttgatttagt 10380
tttttgataa cttcagacat ttgtttgtta tctaaatctt ctaatttagt ttcaggtaat 10440
aactctaatt tatcccaaac ttcttcttta ttagatactt tattattaat aattgcctta 10500
ccaactaaac tttccgtata atataattgc tttgctgatg ccatttgtat ctctcctttt 10560
aaatatgtaa agtatatagc tagtatcgta tcctaggaac aaacacttgc gctatatact 10620
caatgaaact ctaccctcat tcgaggacac agcaaaccga ttcgtcaacc gcacatgtga 10680
attctcaagt ttcatttatg taacacaccc tctttgattt gcacaaagac taagggtttt 10740
ggagaccctt gtactactaa ttatactaag ggtgtttatt atggtttcta ttggatttga 10800
accaatgaca cctagagctt caatctagtg ctctaccatc tgagctaaga aaccttgtaa 10860
cgactcatac gagactcgaa ctcgtactct ctgccgtgac agggcagtgt gttaaccagt 10920
tacaccaatg agccaaaata aatgctatac cctaacctta ccttgatgta tagcaggttt 10980
tcatataagc tcgaagcaac gattattacc actcataaca actatatatt aagtgaaagg 11040
aggtgaaatg aacaaaacgt ggtaattggt acttatatag gaagtatgta taatctacaa 11100
ggagtaagtt attggttcat aaaggagtgt gaacaataaa tacatgaaag agtgaaagtc 11160
tactccttgt agattctttt ttaattatca atcaaaggag gaaactgata attgttaata 11220
ataaactata aagaggaaaa tatttatagt cacattctga tataatgcaa ctaaatatcc 11280
aagcataacc cgtctcacga ggaacctacc tataagacct gttattaagt gaatcactac 11340
gattgactct attaaggagc taccttaagt ccatctcacg caatttaaaa gggacttaca 11400
aaccgtataa cgatagtaag tttattaaat aatgtgatat taacatatta gttaataact 11460
ttcacatggt cgaagaaaag taaatttatt tgatttccaa attattttta tcaaatatag 11520
cttcttttga acctgtagat ttatgctact catactaata acctctatta tctaacacat 11580
ttctgtgctc caactacagt tagtcgttac agcgtatctt tctaggattc cgctaagacc 11640
ctagaaagaa attaaaccct agccgttatc atactctaca gaccttataa gtaagtacca 11700
agtataccaa tcgtatttaa caatactaat gacgacccat cctaccgata tatttccgat 11760
aggttttgat tcgtttgatt atcttgtacc ttatgactac caaatcatta ttcagtcact 11820
atgctcagat atttagttgt attattatat attaattata acataatttt tagtacttgt 11880
caagttaatt ttaaaaaaaa ttatagaagt aagataaaat tcttacttcc aattaaaatt 11940
ataaggatga tacacattgt tattgtttaa actggaaaac aatgtaagaa aaaacagtga 12000
tgtgtaaggt atttgtttta ttgttaatta cattatagca tatactgata cctttgtcaa 12060
gttaatttaa tacttttttt aaaatattag ttatcttttg ttagttcttc ctgaatagca 12120
tcccatcttc tttctgcttc actacgatta tcttctatat gttttgtagt tttacaacat 12180
ttgatacagt atatatcttt gatatgacct tcttctcttt tatttgctct ttttcttggt 12240
actttgaata cattaccaca ttctttacat attaaacttg agtaaaacat tttttgtctt 12300
ttcataatta atcaattcct tttcttgttt tatttgataa tttaactata tactatattg 12360
ataaataagt caacagtttt ctaaaaataa tttaaattat tttgaagaat cctttaatac 12420
caagggttac aagagaaaaa gtacgtattt agaaaataag gagtactcct attatatata 12480
attatattct gatataagta attaataata ttaaatatat aattataatt aataaggttg 12540
ggaaaattga attaaatata atctgatact tggtaaaact actcaatata gaagtaaaat 12600
cctttagtat cagtacttac agacaaaaaa gtacgtattt agaaaataag gaactctcct 12660
attatagtta tatatactta ttaattatta ttaattacta tctaaatata taattataat 12720
taataaggtt agagagtcaa caaaaagaca aataaaaaag tgactactta aagtcacttg 12780
ttaatttaaa aaactatttt aaatgattca atcattcttg ggttaatata aattaaacta 12840
gaactagcat cttcagttgt attaactttt attgatgctg aatcagaacc actaatcata 12900
tagtctatat cttttctagt gtaacccttt tcgtcagatg atactaaaaa atatttagca 12960
ccacttaaca ttgttatttc aatatgtttt gacatctaca atctctccta tgcaaatttg 13020
ttaaagacaa aggatagtat agcacctaga acgagtaaaa gaaccttctc agtagtatcc 13080
ttcttcctag tatctttagt ttttgtactt tcagcaagtt ctgaaatctt ttcatcaagt 13140
ctttctaatt ggacgtaaat tgctgattgt ttttcactat tgacagctac atctttatct 13200
atactaacta tcatttttct tagttcagct acctcaactt ctaaatcttt gaaagttcct 13260
ctatctatat aattaccttc ttgtatctta gacttaatag tttctacttg agaaacaagg 13320
ttgtttatct ccttatccaa ctagaatcac ctctaaggtc taaccgtttc agattcagaa 13380
tggatatcat aattttctaa gaaatcattg ataatctcca tataattatc cgtaacgact 13440
tttccgtaag atgtttttgt atcaatttca aacctaagct taccaaaact ttggaggtct 13500
aattctttta ttacaatatt agggtcatca gaaggaaggt aataatagtc gaagtatata 13560
attgagccat ttattaatac tctgtctatt ctatagacgt ggaaatagcg tctgtctctt 13620
ttaaaatggg ctagtgcatc tttaaactct aacttaagga tatccttata tttagtcaaa 13680
gtggtaacct ccttactatt aatttttaaa tttacttatt ttgtggtata atagttatga 13740
taaaggcagt tattataatt atattaagaa taatgataat aattattttt tctgagaaaa 13800
taagccaaat actaaaaaca gataaagcat agatagctga tagatatact atattaagag 13860
ttaccttact tttatcttct ttatagatag aataacctaa agacgttgta acaccactaa 13920
gtataaaata atagaaacaa aaaagaggta tagacagaaa aaaagatacg ataatcattg 13980
ttaaacacct atttcttttt gacctattat ttatagaact tttagattac accactaata 14040
taacattaaa agccagtcat aaaagtcaat tgttagatta ataatataat aaaaaaagac 14100
aataggaggt taaagtggtt gaataataac atagctatat tcatattcaa aacactggtt 14160
atcattatat tcttactact aattttgtct gttattaatt ccttgtccct tatttattca 14220
ataagaccga gtgtagttat gacatacttt atatttggtg gtattgtttc taatgtcgca 14280
cttactataa cagataagtt cttactgaag aaagaagacc ccctacctga atatgttctt 14340
aaaaaagtag agataaatga taaagaaata agaataatca agaaaatcat agaaagtaac 14400
tacggtataa cagcagaaga gataaaagtt agggctaaag cacaaagaag aatagaggaa 14460
gatagtaaaa aggaagatta cgatgaaaac aaagaaagaa attaaagaac aaaggaaaga 14520
gcttaaggat ggtgctacat ctgtttcttt agtaaaaaaa ggagataaga gaatagctag 14580
ccctagtaga atttgtagcc tatgcggtca gcagttatca ggtatgaatt acactaaagg 14640
aaaagcatta tcaaaagtta atcattttca tttacagtat tctaagtata tttattttga 14700
tatttgcgca gatatcaaca attgttataa gaatttaaga aaaagaggtg aaatggattg 14760
agtgcagaaa atattagaga tataattaac aagaaaaagt tagaagaaga ggatacaaga 14820
aaatatatag ctgatggatt tatgaatggt ataggtaaat taatgtatga attcaataaa 14880
aaagtagata ataaagaaat agaagttaaa gaccctaatg atttatataa actattcgtg 14940
atattctctc aaatgcaaaa tatggttaat gaaacttctg aaggtggagc aatacctcag 15000
ctatctagac ctcagcaaga attatttgac gagattacaa cagaagatag taatggagaa 15060
tctacagttg atttacagaa gatacaagaa atgacagcag aagatattac agcaatgatt 15120
tctgaaaaag aaaaagtaat gaatgaggaa aattcagaaa cattctaagg agaaagatat 15180
aaatggatgg aaaagaacta attaagatag cacaagaaac atttcaaact gaaaaaataa 15240
caagagaaca gatagaccat ataatcaata tgttaaaccc ttctacctat atgcttaagt 15300
atcacacact aagaggacac cctataactt tcagcattcc taatagagat agaagtaaag 15360
cacaggctca tagaccatgg caaactagga ttgtaaacga tactcatcct aataaggctg 15420
taataaaatc acgtcagtta ggtcttagtg agatgggtgt aatggaaatg gttcattttg 15480
cagatatgca tagttatgcc aatgcaaagt gtttatacac attccctaca aatgaacaaa 15540
tgaaaaaatt tgttcagtct cgtttgaacc ctgtattaga aaaagaatat tttagagata 15600
ttgttgattg ggataaagac tctttaggtt ttaaaaagat aagaaactct agtttattct 15660
ttagaacaag ttctaaagca agtactgtag agggtgtgga tattgactac ttatccttag 15720
atgagtatga tagggtaaac ttattagcag agtcatctgc attagagtca atgtcttcat 15780
caccttttaa gattgtgaga agatggagca caccatctgt acccggtatg ggtatacaca 15840
aattatatca acaatctgac caatggtatt atggtcatag atgtcaacat tgtgattatt 15900
taaatgaaat gagttataat gattacaacc ctgataatct tgaagaaagt gggaatatgt 15960
tatgtgttaa ccctgaaggt gtagatgaac aggctaaaac agtacagaat ggtagttacc 16020
aatttgtttg tcaaaaatgc ggtaaaccac tagatagatg gtataatggt gagtggcatt 16080
gtaagtatcc tgagcgtaca aaaggtaata aaggggtacg aggataccta ataacacaaa 16140
tgaacgctgt atggatttct gctgatgaat taaaagaaaa agaaatgaat acagaatcta 16200
agcaagcgtt ttacaattat attttgggtt atccatttga agatgttaaa ctgagagtta 16260
atgaagaaga cgtttatggt aacaaatcac ctattgcaga aacacaatta atgaaacgag 16320
atagatattc tcatatagct attggtatag attggggaaa tactcattgg ataactgttc 16380
atggtatgtt acctaatggt aaggtagact taatacgatt attctctgtt aaaaagatga 16440
caagacctga tttagttgaa gcagatttag aaaaaatcat ttgggaaata tctaagtacg 16500
accctgatat tataattgca gataacggag attcaggaaa caatgttcta aaactcatta 16560
atcattttgg aaaagataaa gtatttggat gtacgtataa atcttctcct aagtctacag 16620
gacagttgag acctgaattt aatgagaaca ataatagggt tacagtagat aaattaatgc 16680
agaataaaag atatatacaa gcacttaaga caaaggatat aagtgtttat agtacagtag 16740
atgatgattt aaaaactttc ttaaaacatt ggcaaaatgt tgttattatg gatgaagaag 16800
atgaaaaaac tggagaaatg tatcaagtta ttaaacgtaa aggtgacgac cattatgcac 16860
aagcaagtgt ttatgcctat ataggattaa caagaataaa agaacttctt aaagaaggaa 16920
atggtacaag cttcggttct acatttgttt ctactgatta caaccaagaa ggaaataagc 16980
aattctactt tgatgaatag aggtgaaata gacttgacaa ataaattatt ttatggtaca 17040
attagtaatg aagaaattaa taaaagtgta ttgaatttgt tattaggtga ggaattatct 17100
ttagattatg tttctaaaaa tagtgatacc ttagatgtta aatatgaaca tgtttataaa 17160
tctctaggat tcgataattt ctttgattgt tttttatatg ctaatagaga acctgaaata 17220
gtccataaag gtggagataa aaatcttggt gggctaaata aggttaaacg tactgttatt 17280
cgtaatggta aagaaatgga aatgacagtt tacgaagatg gtaataaaga aaataatagt 17340
aaagaaaaac aagagggcaa agaagaagtt agtagaagtg cagtaggagc aagagctatt 17400
tctaatggtg aagaaggaaa ggtaaaccct aaaaaggtag caaactcatt atctagttta 17460
agtaaaaaag gtgtcgatgt atcacatgtt agtacaaact cgtcattgta taaagagttt 17520
gttgatgata atggtgatac attaggaatt acatctttta aaagaactga aaatgatata 17580
atattagaat cttatgcaag ttcacctgat tcagatggtg taggtgctag agctattatg 17640
gagctattac gtttaagtat taaggaaaat aaaaatgcag ttgtgtatga catagaattg 17700
cctgaagcta tagagtattt aaaaacttta ggatttaaac ctaataaaga tggatacatc 17760
ttaagaaaaa aagatgtaaa acaattctta ggtgattata gtgattttat ttagcactgt 17820
agtcatctat tctattgtat ttattgtcta tattatatta aaaacaattt atgtaaagtc 17880
taatatgaat agaatagata acacaactga attattaaaa atattacagg aagatattga 17940
aggaaagata aaaaaggaag gaagaaataa atgactttag aagaaaataa attaacatta 18000
gaagaatcaa taactccact tagtaaagag gagaaagagg atagtattaa agaatttagt 18060
agtttattat gtgaaatggt aaatagatta tataagtctt acaatgtatt tagacaagac 18120
cctatggatg aaacgcaacg tttagatggt tctctaatgg tctttcaaag tagactaaat 18180
gaccctttaa caggagattt acatgacaag atgtataaac ttgctttttc aaaacgcatt 18240
gatatttttg aagctaacaa gcaattcaga aaagatgtag aatcaggtaa agcaattgaa 18300
ctaggtgatg tagctattat agatacagca ttaagtaata ttctttcagg taacgagttc 18360
caaggaagta tttcgtttat gcttagaaaa gactttgaag aaaaagaaag aattagaaaa 18420
gaagaagaag agaaacttaa taacttataa aagggaagaa ttatgagact atataaaatg 18480
aggtatcata attgaaaaag aaaccacaag gcaatgagat aatcataacc ataataacgg 18540
ttatgatagc aatatttgta gtcattatga ccatattttt taataaatac caagatgcta 18600
aagaagataa agatagatat cagagattag ttgagattta taaaaaagca gatgataatg 18660
atggagagac taaaaagaaa tacgtaaaaa gattaaataa agctgaagaa gaacttaaaa 18720
aagtaaagaa agaaacaaat tataaagact ataataagaa gtcaaataaa gaaagacaaa 18780
aggaagataa agaaactaga gagaaaatat atgatgtaac tggtgatgat gacttaatat 18840
tagtaaaaaa taatattgag tttagtgata aggtagataa acctgaaata cttattagtg 18900
aagatggaat tggtacgata actgttccta caaacagtgg ttatgaaaaa caaacagtag 18960
gttctattat tactagtgta ttaggttccc cgttcttatc aaatgattca cccggtatag 19020
atagtttagg tatcattaat agtaatgttt atccaaatac agtagatagt atagtagaag 19080
acacaaatac ttctactgat aatgtactaa aggataatac tattataaca aatccagttg 19140
aaccaaccac accttcagat atattacctc ctattgataa tccgtcagtt cctatattac 19200
ctgaaaatcc tgtagacaat aattcaggaa atatagataa tacggataat ccaaaccctc 19260
cacctccagg atatacagat gaagatggag gtagaggctc aggtggtgga ggtaatgttg 19320
aacccccacc aacggaagaa ccttcagata acggtaatac agggggagga gattgggaag 19380
aaaaacctga cccaggagaa gagccatcag ataatggtaa tacaggagac aatgaaggag 19440
aggtaactcc tgaacctgac cctacacctt ctgagcctga acaacctaat gaaaaacctg 19500
atgagggtaa tggtaatgaa gaaaaaccat ccgaaccatc agataatcct gatgaaaatg 19560
gaggatggga aactgagcct tccgaacctg aaacaccttc tgagccggac gataaggtgg 19620
acgaagagga taaaaacgaa gatacaacag aggataaaca acctacagaa caaccggacg 19680
ataataatac agataatgag gataaaactg aagaggagta attactcctc ttttttgttt 19740
gctatattaa ataagagata aatataaaaa aaattgaaca ttacggtggt gaaaactttg 19800
ataggaatga atgttataac gtcactatca gtagtattta cctgtttaag tcttttaact 19860
ttaatgattt ttgttcacag taagttctcc agtaaaaacg tttttgtttt gtatgtaatt 19920
tatgctataa taggaatagg tacatacata gttttaacta tgtttcaaac aacatctgta 19980
cttattaaga atgatgtaat agattccata gaaaatactg aacattatat tggattcaat 20040
gaccctataa ttatatttac tataagtttt ataggggcaa tacttggagg aatttggtac 20100
aagatgatga aaattattaa aaagagtaac tttaaagata aaaaataaaa aagacggtga 20160
ataggttgat attctctaaa gataagaaat gggatgaagc aaaagatttc atcaaaggtc 20220
aagggatgca agataattgg atagagattg tagattatta tagacagata ggtggaaaac 20280
acgtagctgt ttttattgct ttaaacaaag taaaatacat gattctagaa gcaacaaaag 20340
acaataaagt aatattagta gataaagata ataatatact attagaagat tatgatattg 20400
ttatggaaag taaaaaaatg ttttattaca ttgaagaacc gttcgaggtt aaaataaata 20460
tccctcaaca tattagagat gtaacttata ataatactgt tgtattaact acagtaagag 20520
ggagtagagg tgactagtaa ttggcagatt tatttaagca attcagatta ggtaaggact 20580
atggtaataa tagtaccatt gctcaagttc ctattgatga aggattacaa gctaacatta 20640
aaaaaataga acaagacaat aaagagtacc aagacttaac taagtcttta tacggacagc 20700
aacaggctta tgcagagcca tttatagaaa tgatggatac taatcctgaa tttagagata 20760
agagaagtta catgaagaat gaacataatt tacatgatgt tttgaaaaag tttggtaata 20820
atcctattct taatgctatc atacttacac gttcaaatca agtagctatg tattgtcaac 20880
ctgcaagata ctcagagaaa ggtttaggtt ttgaggtaag attaagagac ctagatgcag 20940
aaccaggtag aaaagaaaaa gaagaaatga aacgtataga agattttatt gttaatacag 21000
gtaaagataa agatgtagat agagattcgt ttcaaacttt ctgtaagaaa attgttagag 21060
atacttatat atatgaccaa gttaactttg aaaaagtatt taataagaac aataaaacta 21120
gattagaaaa attcatagca gtagaccctt ctactatttt ttatgcaaca gataaaaaag 21180
gtaaaattat taagggcggt aagaggtttg ttcaagtagt agataaaaga gtagtagcta 21240
gttttacttc tagagaatta gctatgggta taagaaatcc tagaactgaa ttatcttctt 21300
cagggtacgg attatcagaa gtagagatag ctatgaaaga atttattgcc tataataata 21360
ctgaatcatt taacgataga tttttctcac atggtggtac tacaagaggt attttacaaa 21420
tacgttcaga ccaacaacaa tcacaacatg cattagagaa ttttaagcgt gaatggaaat 21480
ctagtttatc aggtatcaat ggttcatggc aaattccagt ggtaatggca gacgatatta 21540
aatttgttaa tatgacacca actgctaatg atatgcaatt cgagaaatgg ttaaattatc 21600
ttattaatat tatatctgct ttgtatggta ttgaccctgc agaaattggt ttccctaata 21660
gaggaggagc tacaggttct aaaggtggtt ctactttaaa tgaggctgac ccaggtaaaa 21720
aacaacaaca atctcaaaat aaaggtttac aacctttact tagatttatt gaagatttag 21780
ttaatagaca tattatatca gaatatggag ataaatatac attccaattc gtaggtggag 21840
atactaagag tgctacggac aaacttaata ttcttaaact agaaactcaa atatttaaaa 21900
cagtcaatga ggctagagaa gaacaaggta agaaacctat tgaaggtgga gacattatct 21960
tagatgcttc attcttacaa ggaacagcac aattacaaca agataaacaa tataatgatg 22020
gtaaacagaa agaacgttta caaatgatga tgagtttact agaaggagat aatgacgatt 22080
cagaagaaag tcaatcaaca gattctagta atgctgataa agaaatagga acagatgcgc 22140
aaataaaagg tgacgataat gtttacagaa ctcaaacatc aaataaaggt caagggagaa 22200
aaggagaaaa atcttctgac tttaaacatt aattaataag cctagaataa atctaggctt 22260
tgtttatttt ttttgtaatt taattttgat aaaggtaata actatgatat actatatgta 22320
attgatatta atacataaaa aatattaata tttcacttac aagttattat tgttatatta 22380
ttaacgtaaa agtaaataaa ataacaagtg gaggtgtaga cacctttgga agaaataaaa 22440
tttaatgctt ttgtacctat ggatttgaag aaatctgtat caacagcttc tgataccaat 22500
gagtattcta tagtttcagg atgggctagt actccaagta tggatttaca gaatgatata 22560
gttaatccta aaggaataga tatagagtat tttaagtcac aagggtacat taattatgag 22620
catcaaagtg ataaagttgt aggtatacct acagagaatt gctatgtgga tatagaaaaa 22680
ggtttattta ttgaagcaaa gctatggaag aatgacgaaa atgttgttaa gatgcttgat 22740
ttagctgaga aattagaaaa atcaggtagt ggaagacgtt taggtttttc tattgaaggt 22800
gcagttaaaa aacgtaacat aaatgacaat agagttattg acgaagttat gataacagga 22860
gttgcattag ttaaaaaccc tgctaatcct gaagcaacat gggaaagctt tatgaaatca 22920
tttttaactg gtcatggtac atcacctgac actcaagttg atgcaggagc tttaagaaaa 22980
gaagaaatag catctagcat tacaaattta gcttacgtca ctaagattaa agatttaaaa 23040
gagtttaatg atgtatggaa tggcgttgtt gaagatttga gtaaatctaa cagtatggga 23100
tatgaggaat cagtccttac gttacaacta gctaaaggtt tatctcgtaa agatgcagaa 23160
ctagcagtaa tggatataaa caaacaaaaa ctagaatagg taaggagaat acattctatg 23220
agtaaagaaa tgcaaaatat tttagaagag tatgataagt taaatgctca agaggcagtt 23280
tcgaaatctg tagaagatga tgaaaagaat acagtagaat ctaccgaaga acaagtagca 23340
gaaacaactg aagaaccggc taaagaacct gaaaaggtta ctgaggaaga tgctaaagaa 23400
gcacaagagc aaggtgaaaa agttgaatct gaagaggtaa cagaggacac tgaagatgag 23460
gaagttgaaa aatcagctaa agaatcaaaa gaccctgtag accaaaaaga tactaaaaca 23520
gaaaataaag acaacgagaa acgtaaaaat aaaaaagata aaaaagaaga ttctgaatct 23580
gacgatgatg aagacaaaga tactgacgat gataaagata agaaagaaga taagaaggaa 23640
aaaacttcta aatcaatttc tgatgaggat atcacaacag tatttaaatc tatcctaaca 23700
tcttttgaaa acttaaataa ggagaaagaa aactttgcta ctaaagacga tttaagtgaa 23760
gttagtaaat ctattaatga gttatcagca aaaatttctg aaatccaatc tgaagatgtt 23820
tctaaatcag tagacactga tgaagaagaa gctgtagaaa aatcagtaac atctacaaat 23880
ggggagcaag aaaaagtaga aggttatgtt tctaaatcag tagacactga agagcaagct 23940
gaaactggtg aagcaaaatc agaagatgct gaagaagtac aagaagacaa cacatttaaa 24000
ggattaagtc aagaagaaag aactaagttc atggattctt ataaagcaca agctaaagac 24060
cctagagctt ctaaacatga cttacaatca gcttatcaat cttacttgaa cattaacact 24120
gaccctacta acgcatcaga gaaagatatt aaaactgtaa aagactttgc acaaatttaa 24180
ttaatgcaca aagttgtgtt atattatacg gtgtaactaa agaatataaa tagggtacat 24240
tttactgtac cctacataaa ataaaaagaa cacaaatgaa aggtgataaa tttatatgac 24300
tatcgaaaag aacctgtcag acgttcaaca aaagtacgct gaccaattcc aagaagacgt 24360
agtaaagtca ttccaaactg gttatggaat cactcctgat acacaaattg acgcaggagc 24420
tttacgtaga gaaattttag atgaccaaat cacaatgtta acatggacta acgaagattt 24480
aatcttctat cgtgatatct cacgccgtcc tgctcaatct acagtagtaa aatacgacca 24540
atatttacgt cacggtaacg taggtcactc tcgtttcgtt aaagaaatcg gagtagcacc 24600
agtatctgac ccaaatatcc gtcaaaaaac cgtatcaatg aaatacgttt ctgatactaa 24660
aaacatgtca attgcatcag gtttagtaaa taacattgct gacccatcac aaatccttac 24720
agaagatgct atcgcagttg ttgcaaaaac aattgagtgg gcttcattct atggtgacgc 24780
ttcattaact tctgaagttg aaggtgaagg tttagaattt gatggtttag ctaaattgat 24840
tgacaaaaat aacgtaatta acgctaaagg taaccaatta actgagaaac acttaaacga 24900
ggcggctgta cgtatcggta aaggtttcgg tacagctaca gatgcttaca tgcctatcgg 24960
tgtacacgca gacttcgtta actcaatctt aggtcgtcaa atgcaattaa tgcaagacaa 25020
cagcggtaac gttaacactg gttacagcgt aaatggtttc tactcatctc gtggattcat 25080
taaattacat ggttctacag taatggaaaa tgaattaatc ttagatgaat cattacaacc 25140
attaccaaac gctcctcaac ctgctaaagt tacagctaca gttgaaacta agcaaaaagg 25200
tgcttttgaa gatgaagaag accgtgcagg attatcatat aaagtagtag ttaactcaga 25260
tgacgctcaa tcagctcctt ctgaagaagt aacagctaca gtatctaacg ttgacgatgg 25320
tgttaaactt tcaatcagtg ttaacgctat gtaccaacaa caaccacaat ttgtttctat 25380
ctaccgtcaa ggtaaagaaa caggtatgta cttcctaatc aaacgtgtac cagttaaaga 25440
tgcacaagaa gatggaacaa tcgtattcgt agataagaac gaaacattgc ctgaaacagc 25500
agacgtattc gttggtgaaa tgtcaccaca agtagttcac ttattcgaat tacttccaat 25560
gatgaaatta ccattagctc aaattaatgc ttctattaca tttgcagtat tatggtatgg 25620
tgcattagca ttacgtgctc ctaaaaaatg ggctcgtatt aaaaacgttc gttatatcgc 25680
agtttaatag aataagaaaa actgaataca agagaatagg gataaactta gggtttatcc 25740
cttttttatt aaaataaact tgaagggact taataaatat gttatactat aagaaattac 25800
taaatacaaa aatggctacc atttatggta cagtagatat tgacaaagat ggagtagtta 25860
aaggattaac taaggaacaa gaaaaagagt ttgcaaacgt tccaggtttt gaatttgaag 25920
aagaaaagaa aactactaga aaacaatcag cttctactag taaagaagaa gaacctaaag 25980
aagaggaaaa gaaagcctct actagaaaaa ctacaagtac tactagaaaa tctacagcac 26040
gtaaaacaac agccaaaaaa gatgaaaata agtaaagggt gaattaaatg gttaactcaa 26100
tgtttggagg ggacttagac ccttatgaaa aatcattaaa ctatgaatat ccttatcatc 26160
ctagtggtaa tcctaaacat atagacgtaa gtgagataga taacttaaca ttagctgatt 26220
atggatggtc acctgatgca gttaaagctt atatgtttgg tattgtagta caaaaccctg 26280
atacaggaca gcccatgggt gacgagtttt ataaccatat attagaaaga gcagtaggta 26340
aagctgagag agcgctagat atttctatac tacctgatac tcaacatgag atgagagatt 26400
atcatgagac agagtttaat agttatatgt ttgtacatgc ttacagaaaa cctatattac 26460
aggtagagaa cttacagcta caatttaatg gtagacctat atataaatac cctgctaact 26520
ggtggaaagt agagcattta gcaggtcatg ttcaattgtt ccctacagca cttatgcaaa 26580
caggacaatc aatgtcatat gatgctgtat tcaatggata ccctcaatta gcaggtgtat 26640
atccaccatc aggagcaacc tttgcacctc aaatgatacg actagaatac gtatcaggta 26700
tgcttccacg taaaaaagca ggtagaaata aaccttggga gatgcctcct gagttagaac 26760
agctagttat aaaatatgca ttgaaagaaa tataccaagt atggggtaac ttaatcattg 26820
gtgccggtat tgctaataaa acattagaag tagacggtat cacagaaaca ataggaacta 26880
ctcaatcagc tatgtatggt ggggctagtg ctcagatact tcaaataaat gaagatataa 26940
aagaactatt ggatggttta agagcttact ttggatataa tatgatagga ttataaggag 27000
ggttagaaaa tggaaaaacc gtatatgata ggagccaact ctaaccctaa tattattaat 27060
aagtcaacaa catacactac tacaacacaa gcagatgaac aggataaacc taagtatact 27120
actaggctag agtttgatac tattgatatg attaggttta ttaatgatag gggtataaaa 27180
gtactatggg aagaagcata tttttgtccg tgtcttaatc ctgacacagg tcatcctaga 27240
gtagattgtc ctagatgtca tggtaaaggt attgcttatt tacctcctaa agagactata 27300
atggcaatac agtcccaaga gaaaggaact aaccaattag atatagggat attagataca 27360
ggtactgcaa taggtacaac tcaattagaa aagagaatat cctatagaga taggtttact 27420
gttcctgaag tattaatgcc tcaacaaatg atttattttg taaataaaga tagaattaaa 27480
aaaggtatac cattatacta cgatgtaaaa gaagtaactt atatagccac tcaagatggt 27540
acagtctatg aagaagatta tgaaattaag aataatagat tgtatttaaa tgaaaaatat 27600
gagaaccata cagtaacttt aaagatactt atgactttaa gatatgtagt atcagatata 27660
ctaaaggaaa gtcgttatca atatactaaa tttaatcaac ctaaatcaaa atttgaaaac 27720
ttacctcaaa aattacttct taaaagggaa gatgttattg tactacaaga cccttataaa 27780
gttaatgatg gtatagaaga agacctagaa attcaagtag atgaccctaa agcttccgca 27840
tctaatccta gtaatttagg tggattcttc ggaggtgcat ttaaataatg ccagttcacg 27900
gaaagagacc taatttattt aaaaataaaa actataagca ggtaggtaag agaaccattg 27960
atggcatgcg ttcagaagtt cttgacaagc tacaagcaac agcacagcaa gtagagaata 28020
ctagtattaa acgtatgcct acttatctac aagtaacaga gaaaaagctt gaaaaagaag 28080
gagtagtaga ccttaaaaaa gcatttgctc actcatctaa aaagaaaact agtaaagatg 28140
gtggatggta tttaactgta ccaatacgta ttaaaactag tagaatgaac aacagtactt 28200
atcaagatat gaggacttta aaagtagata aaggcacagg ttcagtttct aagataactg 28260
attatctaga aggacgtaga aagaatgtaa gtcacccgtc aatgaaaccg gaacctatga 28320
ctcataacat gactaaagtt aaaagaggaa agcaatcttc ttactttata tttagaactg 28380
tttctagtaa atcacctgct agttcctgga tacttaatag agataaagtt aatgagaata 28440
atttctctaa aacaactcta aaaactgtta agcaactaat gaactggaag atgaaaaatt 28500
taaattaaga ggagggttag tattaaatgg caataacatc agttgattca tatttattat 28560
cagaaataaa gcctagactt aacactgtgc tagagaattg ttatattata gatgaagttt 28620
taaaagactt tgattatcaa actagagaga gctttaaaga agctttctgc ggtaagaatg 28680
cacaacatga agtaacggta ggatttaact tcccaaaatt taaaaataac tatgaagctc 28740
attacttgat acaattaggt caaggacaag agacaaaaaa ctctttaggg agtattcagt 28800
catcttactt tgaggcaaca ggagatacct tagtcgaatc ttctacagca ataagagaag 28860
atgataagtt agtttttact gtttctaaac ctataggaga attaataaaa gtagaagata 28920
tagagtttgc taaatacgat aatcttcaag ttgaaggtaa taaggtatca tttaagtacc 28980
aaacaaatga agattatgag aattataatg ctaatattat ctttactgaa aagaaaaacg 29040
actctaaagg tttagtaaaa ggattcacag ttgaagaaca agtaacagtt gtaggtctat 29100
catttaatgt agatgttgca cgatgtttag atgctgtatt aaaaatgatt ttaatatcta 29160
tgagagatag tatagaagag caacaaacat tccaattaca gaatttgtcc tttggtgata 29220
ttgcaccaat aatagaagac ggtgactcaa taatttttgg tagaccgaca attattaagt 29280
acacaagttc tctagacttg gattatacta ttacacaaga tattaataaa ctaactttta 29340
aagaaagaaa ggattggaag taggatggct agaaaaaaga cacctgaaaa taacactcct 29400
aaatttaatg gttatgttca tatagataca ttccttgata ctgcaaaaac cctttttaac 29460
atgagggatt cacaagtagc aggatttaaa gcttatatgg aaggtagtca ttatttgttt 29520
agtgagcaag aattcttacc atcattagag aagtatttag gtaggaaatt agatatataa 29580
taacattcag ataaggagaa ttaaatatgg cagtagaacc attcccaaga agacctatta 29640
cccgtcctca tgcatctatt gaagtagata cttcaggtat cggtggctca gcaggttcaa 29700
gtgaaaaagt attttgctta atcggtcagg ctgaaggcgg agaaccaaat acagtttatg 29760
aattacgtaa ctatgcacaa gctaaacgtt tattccgttc aggagaatta cttgatgcaa 29820
ttgaattagc atggggttct aaccctaact atacagcagg acgtatttta gctatgcgta 29880
tagaagatgc taaacctgca acagcagaag ttggcggact aaaaattaca tctaaaatct 29940
tcggtaatgt tgctaacaac attcaagtag gattggaaaa gaacacatta agtgattcat 30000
tacgtttaag agtaatattc caagatgacc gtttcaatga ggtttatgat aatatcggta 30060
atatcttcac aatcaagtat aaaggagaag aagctaacgc aactttttct gtagaatatg 30120
atgaagaaac tcaaaaagca agtcgtttag tattaaaagt tggagaccaa gaagttaagt 30180
catatgattt aactggcgga gcttatgact atactaatgc tattattaca gacattaatc 30240
aattacctga tttcgaagct aaattatcac ctttcggaga taagaactta gaatctagta 30300
aattagataa aattgaaaat gcagatatta aagacaaagc tgtatatgtt aaagcagttt 30360
tcggtgactt agaaaaacaa acagcatata acggtattgt atctttcgag caacttaatg 30420
cagaaggaga agtaccaagt aatgtagagg ttgaagcagg agaagaatca gctacagtaa 30480
ctgctacttc acctattaaa actattgagc cgttcgaatt aactaagtta aaaggtggta 30540
ctaacggtga accacctgct acatgggcag ataaattaga taaatttgca catgaaggtg 30600
gatactacat tgttccatta tcatctaaac aatcagttca tgcagaggta gcttctttcg 30660
ttaaagaacg ttctgacgca ggagaaccaa tgagagctat tgttggtgga ggattcaatg 30720
aatctaaaga acaattgttc ggtagacaag catcattatc taatccacgt gtatcattag 30780
tagctaactc aggtactttt gttatggatg atggacgtaa aaaccatgta cctgcttata 30840
tggtagctgt agctttaggt ggtcttgcaa gtggtttaga aatcggtgaa tcaatcacat 30900
tcaaaccatt acgtgtaagt tcattagacc aaatctatga atcaatagac ttagatgaat 30960
taaatgaaaa tggtattatt agtatagagt ttgttcgtaa ccgtactaat acattcttca 31020
gaatcgttga tgacgtaact acattcaatg ataaatcaga cccagttaag gctgaaatgg 31080
ctgttgggga agctaatgac ttcttagtaa gtgagcttaa agttcaactt gaagaccaat 31140
ttattggtac tcgtactatc aatacaagtg cttcaattat taaagacttt atccaatctt 31200
acttgggtcg taagaaacgt gataatgaaa ttcaagactt ccctgctgaa gacgtacaag 31260
ttattgttga aggtaacgaa gcaagaattt caatgacagt ttacccaatc agaagcttca 31320
agaaaatctc tgttagcttg gtttacaagc aacagacatt acaagcctaa tctaggtgat 31380
ggagtacctg gattaggtac tcctattaat ataatttgaa tactttagga gagtgaatac 31440
agatggcatc agaagctaaa caaaccgtcc atactggtaa taccgtccta cttatgatta 31500
aaggtaaacc ggtaggaaga gcacaatcag catcaggtca acgtgaatac ggtacaactg 31560
gtgtatacga aatcggttct atcatgcctc aagaacacgt atacttacgt tatgaaggta 31620
caattacagt agaacgttta cgtatgaaaa aagaaaactt tgcagattta ggatatgctt 31680
cacttggtga agaaattctt aagaaagata tcattgatat tttagttgta gataacttaa 31740
cgaaacaagt tattatctca tatcatggtt gctctgcaaa taactacaat gaaacttggc 31800
agacaaatga aattgtaaca gaggaaattg agaattttac actctgctca tagagtaatc 31860
tgtgagtatt aagggttaac tgctatgaaa cttctaaagc tcaatcaacc acataggaat 31920
tggaaacaat aaactagaag gttacgaaag tagaaaaaat gattgagata ctctaaggtt 31980
aaatcctaag gagaagtaca atgggtgtat agcatcgaat actctaagtg atagtaaatc 32040
ataagaggaa cgttcaacga ctatctcatt ataagatgag agtaaagctc caagctattg 32100
ggagaagaaa aatccttgcc ctactaatta gggataacaa atagtctagt cacgtagtga 32160
aagctagtgc atgtgaaata acacaggttt acaaagtagc gtttgtaaat aaataaatcg 32220
ttttcgtact tgaccgcatc agataaggct agaacataag ttcgtattta ttatagaata 32280
tagacctaac aataaaagtt aggtcttttc tattgacaaa agactaatga tatagtatca 32340
ttagtatata ctttaataga agaggtgttt taatatggga attgaaaaat tagcaaaaga 32400
aaaacatata aaaatagtag aatatagagg tagagcaaaa gatacaaaac atttaggtgt 32460
tgttttggaa ggtaaattta aaggttgtga atgttacgtg tcctacaata acttaaataa 32520
cttaaaacaa ataagactaa cacaacttac agaagaaggt aaaaagaaat atttttcttc 32580
ttacgctaaa agtagagggt atagtattat aaactatcct gaaaatctgc aatcaacaaa 32640
gagatgttta ttattatccc cgcaaggaaa taaatgggat gttatatgga atagttttga 32700
gaacaatact aataataatt gccctcaaga ccatatgaaa agtattggag agagaattat 32760
acagactata cttaaagaaa atggtatcga atttatatgt gaaaaatcta tctacacagg 32820
attagagaga ccacaaagat tagattttta tatagaatta aatggtaata aatatgctat 32880
tgaatatatg gggcaacaac atattaaaca agctactgga acatggagta cgcccttaga 32940
aaagatacaa gagctagatt cactaaaaga aaaatactgt aaagataata acataaagtt 33000
actatatatc tattatccta atgaagacaa aaaggacata ttaaatacta taagttcgtt 33060
cttagaaatt aatttaaatt atactgagag aatagaactg tttacaaaat ataaagaaaa 33120
tgaaaaagag attatagaat tctataaaga acactcttca gaagaaactg caaataaatt 33180
taatatgagt gttggtaatg ttaaaggttt aatgaaacgt agaggggtta agaaaagatt 33240
taaacctgta gtaggattaa atattaagac actagaagaa attagatttg atactttaaa 33300
agaagcacaa gaatatttta gtaatttagg attaccttca tcaagtatta gagggtgtgt 33360
atcaggaagt aaaaagcaat catgtggtta tctttggaga tatgaagatg aagacttttc 33420
agaagtagct aaaacaataa cagacaaaag aattaaagta tatgtagcaa ctaaaggttc 33480
agaagatatt aagttgcctt tgcatatgat gacaaaaaga ataagttcag atgtagcatc 33540
cattgtagat tgtgctaaag gtaaaagaaa cactgttaaa gggtacaata ttagagaagc 33600
tacagaacag gaaaaaagtg atacactaaa aagtataagt tatattgact atatacaaaa 33660
ttataaataa cccttgacca atatcaaggg ttatgctatt ataataaata aggagggatt 33720
atcttgacaa atagaaaaac aataggtaaa atgagtaata caagggcaac atggaatatt 33780
aaccctgtaa ctaaagttaa gaaagataaa actaaatatt ctagaaaaaa taaacataaa 33840
ggtattgaca attataatta gatacagtat actaagatta taacaaataa ggagatggat 33900
tatatgagta cattttggtc aaaaagaaga acaaccggta aagacaggca agtaaagaaa 33960
cattatactc aaatgtcttt acaagaaaag aagcagtgtg ttaaactatt acaagataca 34020
attaatacac ataaatattt agaactatca aaccattgta aaactaaaat taaaaatgaa 34080
atcaatttta gtaagttagt aggatttata tttaaaagta ataatgcacc ttttaatatt 34140
attgaattta atattacaga ttttcatggt aaaaagcaaa gaaggattat ttttaaaagt 34200
cctactattg taactataga aggagtaagt agttatcagt acttagttat taacctggaa 34260
gatggtaaaa taataactac atactataat ggcattacag atacacacaa aacattagat 34320
ttagattatt atgataaagg cttgacaatt aaataaggag gagttataat gggattaaca 34380
atagtaaata gttattttat tctatcaagt attatattta ttgtattaag tatattaaat 34440
ggtagaggta cagttacaaa tgaatcacta gctatgagta aagcattagt ggtaataaca 34500
tcagctcaat ttttagcatg tttaatcatt aatggtgttt attactcatt aaaatatatg 34560
taataaaaag gagtacaaat gaaaatatac attgtaatag atttaagagg gagtacagaa 34620
gaagaaacaa atatggattt taaagctttt agagaattac aagatgctat agaatatgta 34680
aatggtagta ataatataga tttacacata atgcctttag aattagaata aaagtattga 34740
caaattaaaa ataataaatt ataataaaga tataacaaat taaaggagaa gatataaaat 34800
gacacaaagt aaattaagag cagtatacac agaaatgaaa gtagaattac aaaaattccc 34860
gcaagaggta gatgtaacaa gtaaatcaac tgcaattgca atcaatcaaa ttttagatag 34920
atttaaaaca ttaactgaac aagcaggaaa gattactaag aaatatttag aaggtcaaga 34980
aatattaact attgattatg agtattatga ttcattacaa gaatactaca tttatttact 35040
aagaaatagt gataaaatta aacaaagttt agaggaaatt ttaacaagca cagagaaata 35100
cttaaagtaa ttttgattta aaaacaaaat atgatatact atatttaaag tagtaagcct 35160
acactagtcc gtgttatatt aatattgaat cggataagcg taggctttat taatatttaa 35220
aaaaggaagg tatattatat tatggctgaa gaaattaaaa aggaacaaga tgtacaagaa 35280
acaaaagaag agaaaaaaga tgttagtaaa atgacacctg aagagataga tgaattaaaa 35340
taccaagata ggaaagaaaa agaaaaagtt attaacaaag ttattaaagg tgttaatgat 35400
acttgggaaa aagaatataa ctttgaagaa ttagacttac aatttaaagt taaaattaaa 35460
ttacctaatg cacgagagca aggtaatatc tttgcgttac gttctgctta cttaggtggt 35520
atggatatgt atcaaacaga ccaagtaatt agagcttacc aaatgttagc tacattacaa 35580
gaagtaggta ttgaagttcc taaggaattc caagaccctg aggatattta taacttatat 35640
cctttaactg ttatgtatga agattggtta gggttcctaa actcctttcg ttactaatag 35700
tatagaaaca ttagatacag atatagaacg attgggtggc atggaatcaa ttgttaaaca 35760
acctttatct aggaatctat gggctattat gaaagagttt aatgttttac ctacagagca 35820
aagatttaag gacttagatg actatcaaat agagtttatt atcggtaata tgaacagaga 35880
tatttacgaa cataataaac aacttaaaca agctcaaaaa ggtggcaagt acgatagtca 35940
attcgaagat gatgatagta gttggtggaa tgaatctcat gaagactttg acccggtacc 36000
tgatttctta gatgctgatg acttagcaca acagatggaa gctaaattat ctgatagaga 36060
taaggaagag agagctaaga gaaatgatgc agagttgaat gatgagacag aaggacttac 36120
tacacaacat cttgctatga tggaatacat tagaagaaaa caagaagaat tagatgacga 36180
agtaggaaat ggtaaaacta gtgaagagga tgctacgata tcacaggata gcgttaataa 36240
agcactagaa gacctagatg atgattggta tatgtaaagg gtggtaggtg atactaccat 36300
ccttattttt ttaaaatgga tggtgaataa tgatggcaat gaatgacgat tatagattgg 36360
tcttatccgg tgatagttcg gatttagaaa atagtctgaa ggcaatagaa ctttatatgg 36420
attccctgga atctaaaaat attgatgccc ctttaaacaa tttcttgaag aaattaaaag 36480
taattgctaa agaagttaaa aatgtacagg actcgatgga taaacaggaa ggtaaatctg 36540
ttatatcttc taaagatatg gatgaatcta ttaaatccac tcaatctgct acaaagaata 36600
taaatgaact aaagaaagct ttagatgacc ttcaaaaaga aaacatttct aaaggtatag 36660
cacctgaccc tgaagttgaa aaagcttatg ctaagatgaa taaagttgtt aatgagacta 36720
gtgaaagtct tgagaaaatg tcttcacaaa aaataggctc agacgctagt attcaaaata 36780
gaattaaaga acagaaaacc ttaaataaag taacagaaga atacaataaa attagtaaag 36840
attctagtgc tactagagat tatactaaac gtttaagagc taaccgtaat atgactagag 36900
gttacatgga acgttcagaa ggaacaggac gtttaacata tgaccaagga gcaagagtta 36960
gaagtgaact aggtaaggta gattcttatg aaagtcaaag aaaacaaaac caacgtaatt 37020
taagtcaagc aagagagcaa tatactaatt atggaaacca acaacaagac ctaactaaac 37080
gtagagctag tggtcaaatt aataaagctc aatatgaaaa agaactagct tctattaaaa 37140
tggaaatgaa agctagagaa gaacttatat ctaactatga aaaattagga gcagagcttg 37200
ataaaactgt tcaatactat aaaggttcag ttcagaaaga tttccaatct agagatgtag 37260
accaacaacg aggaacattt ggtagaatgg ttcaagagcg tttaccatct atcggttctc 37320
atgctatgat gggaactaca gctatggcta cgggtttata catgaaaggt gcttcattaa 37380
gtgaaactaa tagaccaatg gttacatcac taggtcaaaa ctcagataat atggatatag 37440
attctgtaag aaatgcatat ggagacttgt caattgataa caaattaggt tataatagta 37500
ctgacatgtt gaaaatggct acttcatatg aagcatctgt aggacataaa agtgatgagg 37560
atacaatggc aggaactaaa caacttgcta ttggaggacg ttctttaggt attaaagacc 37620
aagaagctta tcaagagtct atgggtcaga taatgcatac tggtggagta aattccgata 37680
acatgaagga gatgcaagat gcattcctag gcgggattaa acaatcaggt atggttggtc 37740
gtcaagatga acaacttaaa gcattaggtt ctatagctga acaatcagga gaaggaagaa 37800
ctttaactaa agaccaaatg agtaatctta ctgctatgca atctactttt gcagagtcag 37860
gaagtaaagg attacaaggt gaacaaggtg ccaatgctat taatagtata gaccaaggac 37920
ttaaaaatgg tatgaatagt tcttatgctc gtatagcaat gggatgggga acacagtacc 37980
aaggtcttga aggtggatat gatttacaaa aacgtatgga tgaaggtata tctaaccctg 38040
aaaacttgac agacatggct gatatggcta ctcaaatggg tggtagtgaa aaagaacaaa 38100
aatacctatt caatagaagt atgaaagaaa taggtgctaa cttaactatg gagcaatctg 38160
atgagatatt taaagatgct caatccggaa aattatctaa agaagagtta gctaaaaaag 38220
ctaagaaaat ggaaaaagaa ggtaaaaaag aaggagaaga taacgccact gattataaag 38280
aatctaaatc aggaaaaaat gaccaaaata aatctaagac tgatgataag gcagaagata 38340
cttatgatat ggctcaacca ttaagagatg ctcatagtgc tttagcaggg ctacctgctc 38400
ctatatattt agcaatagga gctattggag catttacagc atcactaatt gcatctgcaa 38460
gtcaatttgg ggcaggtcat ttaataggta aaggagctaa aggacttaga aataaatttg 38520
gcagaaataa gggtggtagc tccggaggta accctatggc aggaggaatg cctactggag 38580
gaggttcacc taaaggcgga ggctctccta aaggtggcgg tactcgttct actggaggta 38640
aaatacttga tagtgctaaa ggattaggag gattcctagt cggtggagca ggatggaaag 38700
gtatgtttgg tggagaatct aaaggtaaag gatttaaaca aacatctaaa gaagcctggt 38760
caggtactag aaaagtattt aacagagaca atggtagaaa agccatggat aaatctaaag 38820
atatagctaa aggtactggt agcggtctta aagatattta taatgatagt atatttggaa 38880
aagaaagaag acaaaatcta ggagataaag ctaaaggttt tggtggaaaa gctaaaggtc 38940
tctatggtaa atttgctgat aagtttggtg atggtggtaa aaatggtatc ctttcacaat 39000
caccaaaagc aggcggtagc gggctaggaa aactaggaaa acttgcaggt ggacttggaa 39060
aaggagccgg agttttaggt gttgctacat ctgccttatc attgatacct gctttagctt 39120
ccggtgatag taaagctatc ggcggaggta taggctctat gggcggagga atggcaggtg 39180
catcagcagg agcttctatt ggagctttat ttggtggtgt aggtgcaata cctggagctt 39240
taataggcgg agctataggt tcttttggtg gaggagctgt tggtgaaaaa gtcggagaca 39300
tggctaagaa ggctaacact aaagaaggat ggaacctagg atggactaat ggagataaag 39360
acggtaagaa taaattccaa gattctttat taggaaaacc tatatctaaa gcatggagcg 39420
gtataacagg tctctttgat aatgacgctg aagcatctga agaagatagc aaagataaga 39480
aaaaaggcgt taaaggtgtt aaaggagata ctaagaagaa agaaaaaatg acagcagaac 39540
aacttagaga aaagaataac caatctgaaa ctaagaatct taaaatctat agtgatttac 39600
ttgatagggc tcagaaaatt attgagagtg ctaaaggtat taatatagat ggaggaactt 39660
ctgatagtgg ttctgatagc ggaggctctg catctgatgt aggtggagaa ggcgcagaga 39720
aaatgtataa gttccttaaa ggaaaaggac tatctgacaa tcaggtagga gctgttatgg 39780
ggaacttaca acaagaatct aatcttgacc ctaatgctaa gaatgcctct agtggtgcat 39840
ttggtattgc tcagtggtta ggggctagaa aaacaggatt agaaaacttt gctaaatcta 39900
aaggtaaaaa atctagtgac atggatgttc aattagatta cctatggaaa gagatgcagt 39960
ctgattatga aagtaataat cttaaaaatg ccggatggag taaaggcgga agcttagaac 40020
agaatacaaa agcatttgct accggatttg aacgtatggg agcaaacgag gctatgatgg 40080
gtactcgtgt taacaatgct aaagaattca agaagaaata cggaggctcc ggtggcggag 40140
gaggtggagg agctctatcc tctacttacc aagaagctat gagtaaccct gtattaacta 40200
ctggttctaa ctataaaggc tctaatgatg cttctaatgc ttctacaact aatagaataa 40260
cagttaatgt taacgttcaa ggtggaaata atcctgaaga aactggagac attatcggag 40320
gaagaattag agaagttcta gacagcaaca tggatatttt tgcaaatgaa cataagagaa 40380
gttactagta attttgtatt gacacaagag tagtatcata gtatactact cttatacata 40440
taaaaataaa aggaagtatg tgtatatgaa aagattaaga agacctaagg taagaataga 40500
gatagttaca gatgataata catttacatt aagatttgaa gatacacgtg actacaatgg 40560
tgatgagttc ggagctaaac ttttaggttt ccaaactaaa aactctatgg aagatgatag 40620
ttctgtattc caaatcaata tggcaggaga tacttactgg gataagttag ttatggctaa 40680
cgatataatc agaatattta ttacacctaa tgatgaccct aatgataaag aaggtcgtca 40740
agaacgttta atccaagtag gtatggtatc acaagtatca aaagtaggta gttatggtaa 40800
tgaccaaact caatttagga taacaggtca atcttttgta aaacctttta tgaaatttgg 40860
attaggagtt attcaggaag ttcaagctgt attacctgaa gtaggttggc ttattgatgg 40920
tgacggagat aatgaagtaa aatttactgg tagctcagcc catgaagtaa tgacaggaat 40980
tatacgtaga ttcataccat atatgaagta taactatact gaaaaaacat ataatacaat 41040
tgataactat cttgattatg atgatttaag tagttgggat gagtttgaga aacttacaga 41100
agtttctgcg tttactaatt ttgatgggtc attaaaacag ttaatggata tggttacagc 41160
tagacctttt aatgaattat tcttcaaaaa ctctgaaaaa acaccaggta aggcacaact 41220
tgtattaaga aaaactcctt ttaatcctac tgagtggaga gctttagata tgattaaagt 41280
acctactgaa gactttattg aagaagatgt aggtaaaagt gacgtagaga catattctat 41340
atttacagct acacctgcag gtatgttaaa agaacttaat ggtgatgtat tttctaaacc 41400
acaatttcac cctgaattga ctgatagata tgggtatact aaatttgaag tagaaaatat 41460
ctatcttagt actaaatcag gttcagctac tgaagactca gattcttcgg gtgatgacaa 41520
tggtactgaa agaggaactt actctaaaat tatgaaagat ttaagtaact atggaagaga 41580
taatatatct aaaggtatag ataagtatac aagtaaatta tcttcaaaat ataaaaactt 41640
aaaaaaagct caagctaaaa aaattataga gaaatttgtc aaagaaggaa aagtaacaga 41700
aaaagaatac gagaagataa caggtaataa agtagatgat gaattaacat cagataacag 41760
accgaagttg acaaaggata aattaaagag tatactaaaa gagaagttta aaacacaaga 41820
tgattttaat aactctaaga aaaagaaaaa agctaagaca gatgcactta aagaattgac 41880
aactaaatat cgtttcggta acaaaacaca cgctacaact ttgttagatg aatatattaa 41940
atacaaagga gaaccaccga atgatgaagc ttttgataaa tatcttaaag ctattgaagg 42000
tgttagtaac gtagctacag acacaggttc agatgcaagt gatagtcctt tagttatgtt 42060
ctctagaatg ctatttaatt ggtatcatgg gaaccctaac ttctacgcag gagatattat 42120
tgttttagga gaccctaagt atgacctagg taaaaggtta tttattgagg ataaacaacg 42180
gggagatact tgggaattct atattgagtc tgtagaacat aaatttgatt ataaacaagg 42240
ttattataca actgtaggag taactagagg tttaaaagat gctatcctag aagatggtaa 42300
gggtagtcct cataggtttg caggtttatg gaatcaatca tcagacttca tgggaggtct 42360
tatgggtgaa gatacttcta aagaactcaa agaaaaaggt gtagcagaga agaaaagtag 42420
tggagataaa gacggtggct ctgatagtgg tggagcacaa gatggaggtt ctctagattc 42480
acttaaaaaa tataatggta aacttcctaa acatgaccca agtttcgttc agcccggtaa 42540
ccgacattac aagtatcaat gtacttggta tgcttataat agaagaggtc aattaggcat 42600
tcctgtgcct ttatgggggg atgccgccga ctggattggt ggtgctaaaa gtgcaggata 42660
tggagtaggt aagacaccaa aacaaggtgc ctgtgttatt tggcaacgag gagacaaagg 42720
tggttctaat gcttatggtc acgttgcctt tgtggaaaaa gttttagatg gtgggaagaa 42780
aatattcatt tctgaacata actgggctac gcctaatggt tatggtacta gaacaataga 42840
catgagctct caaataggta aagaagctca attcatttac gataagaaat aaaggaggat 42900
agtctatggc aacagataaa gaagctaaag atgttattga taaatttata gataatgtgt 42960
ttaattttga tgtattaact acggaaagag ttaaagaaaa agatgaagaa atcaaaaaaa 43020
taactacaga tgatatgtat gaaaaagttg tgtatatacg accttatgtt ggagtaatac 43080
aaagtcttaa ccctcaacat gtacaatatg aatcattttc taataatggt tacgatatag 43140
aagcagaatt aagttttagg aaagtaagtt atttagttga taaagggtct atacctacag 43200
attctttatc cactttaaca gttcacttag tagaaagaaa tcaggagtta ttaatagatt 43260
actttgatga gatacaagat gtgttgtatg gggagtatat ggaagaagaa tatgtatttg 43320
atgaagatgt accattaagt actatactag cattagactt aaatgataat cttaaatcct 43380
tatcaaatat aaagtatatg ttcaaaggag cccctaaaga taatcctttt ggaacagata 43440
aagatgttta tatagatact tataatttat tatattggtt gtatttaggt gaagatgaag 43500
aattagcata tcctatgaat attaactatt tctttacaga aggtagattt tttactgttt 43560
ttggtaaagg tcataagtat aaagtagatg ttagtaaatt tatagttgga gatatattat 43620
tctttggtag aagtgatact aatataggta tttatgtagg tgatggagag tttatatcta 43680
tgataggtaa atttccaaaa gatgagacac ctataggaaa atacaaactt gatgattact 43740
ggaatgaatt taacggaaga gttatgagat tcgatgaaga ggtgtatatt taatggtagt 43800
aagattccaa tcttccatgg ggagaagtct aaaaagagta gattcagatg acttaaatgt 43860
aaaagggtta gttttagcta cagttagtaa aattaattat aagtatcaat cagtagaagt 43920
taaagttaat aacttgactt taggaagccg tataggtgat gatggtagct tagctgtacc 43980
ttatcctaaa tctttcatag gtagaacacc tgagggaagc gtattcggta caaaaccact 44040
tattactgaa ggttctgtag tattaatagg gttcctaaat gatgatataa atagtcctat 44100
aatcttgagt gtttatggtg ataatgaaca aaataaaatg attaatacta accccttaga 44160
tggaggtaag tttgatacag aaagtgttta caaatacagt agttcactat atgaaatttt 44220
accatcttta aattataaat atgatgatgg agaagggaca agtattagaa cttataatgg 44280
taaatcattc ttctctatga catcaggtga agaagagaaa ccgcaggcaa cagattttta 44340
tactggaact gagtatcaag atttatttac ttcctattat ggtaataaaa cattgattga 44400
acctagaata caaaaggctc ctaatatgtt attcaaacat caaggagttt tttatgatga 44460
tggcacgccg gataatcaca taactacttt atttatatct gaaagaggag atatcagagc 44520
ttcagtttta aatacagaaa cacagaaaag aactacacaa gaaatgtcaa gtgatggttc 44580
ttatagggtt attaaacagg atgacgattt aatgttggat gaggctcaag tttggattga 44640
atatggtatt agtgaagata ataaatttta tattaaaaat gataagcata aatttgaatt 44700
tactgatgaa ggaatttata tagacgataa gcctatgcta gaaaatttag atgagagtat 44760
agcagaggct atgaagaatt taaatgaaat acaaaaagaa ctagatgata taaactatct 44820
tcttgagggt gtaggtaagg ataatttaga agaactaata gaatccacaa aagagtctat 44880
agaagcgtct aaaaaagcaa cttcagatgt taatagactt acaactcaga tatcagaggt 44940
tagtggtaga actgagggta ttataactca attccaaaaa tttagagatg agacttttaa 45000
agacttttat gaagatgctt ctactgttat taatgaagta aatcagaatt tccctagtat 45060
gaaaacagat gttaataatc taaaaactaa agttaataac ttagagaaaa ctgagatacc 45120
aaatatcaaa aataggttaa cagaactaga gaataataat aacaatgcag ataaaataat 45180
ttcagataga ggagagcata taggtgctat gatacagtta gaggaaaatg ttactgtacc 45240
aatgagaaaa tatatgccaa taccttggag taaagttact tataataatg ctgagttttg 45300
ggattctaat aaccctacta gattagtagt acctaaggga ataacaaaag taagagttgc 45360
aggtaatgtc ctatgggatt ctaacgctac aggacaacgt atgttgagaa tattgaaaaa 45420
tggtacttat agtttagggt taccttatac aagggatgta gctatatcta ccgcacctca 45480
gaatggtact agtggagtta ttcctgttaa agaaggagac tactttgagt ttgaggcttt 45540
tcaagattca gaaggtgaca gacaattcag agcagaccct tatacatggt ttagtattga 45600
agctatagaa ttagaaactg aaaccatgga gaaagacttt atgcttatag gtcatagggg 45660
agcaactgga tatacagatg aacatacaat aaaagggtat caaatggctt tagataaagg 45720
tgcagattat atagaattgg atttacaatt aacaaaagat aataagttat tgtgtatgca 45780
tgattctact atagatagaa caacaacagg aacaggtaag gtaggggata tgactttatc 45840
ttatatacaa actaacttta catctcttaa tggtgagcct ataccatctc ttgatgatgt 45900
attaaatcat tttggaacaa aagttaaata ctatatagaa actaaacgtc cttttgatgc 45960
taatatggat aaagaattat taactcagtt aaaatcaaaa ggattaatag gaattggttc 46020
agaaagattc caagtaatta ttcaatcatt tgctagggaa tcattaatta atattcataa 46080
ccaattttct aatatacctt tagcttattt aacaagtaca ttctctgaaa gtgaaatgga 46140
tgattgttta agttatggtt cttatgctat tgctcctaaa tatacaacga taactaaaga 46200
gttagtagat ttagcgcata gcaaagggct taaagtacat gcatggacgg taaatacaaa 46260
agaagaaatg caaagtttaa tacaaatggg tgtagatgga ttctttacaa attacctaga 46320
tgaatataaa aagatttaat attaaagacc tattaattta ggtctttttt tagttgtaat 46380
ttaaactagt tcgtgatata ttagtagtat gagatttata tacatactga aaaggagagg 46440
ataaaatgcc acaatcagat ggaataagta atcttcatag aatagcttta cgcttcccta 46500
aagaaggcgg tggttatgat atgtataggt ttaaagttaa tcctgagaat tacacaatag 46560
attcaccaca acgtacgaca gcaattaaaa caaaatcaga tattgtaata gaagattatg 46620
gtaaagacat agaagttatt aacttcacag gtacaactgg ttttagacct gttagagaag 46680
cagatggatt aaaaacaggt aagcagaaga tggaagagtt acagagtaga gttagtgaat 46740
atgctatgca aggtggtagt ggtaacgtaa gtggctctta tttacaattt tttaacttta 46800
cagatgatag ctactataaa gttcatttag cccctcaagg gttaaaggta actaggtcta 46860
aggatgaacc gttacttttt agatatgaaa taacattagt agtcatcggt tcattaacag 46920
aagcagatag aagtgctgta acaacagaag agtttggtaa tgttaaacct aacgcttctc 46980
aaagagtaga tgaaggcata aaagaactag ataaaaatgc tcgtaaaacg agagatagaa 47040
ataaccaaga aatatctaga agagaaaata caatacctaa atctacagga gataatacaa 47100
acgagggtaa taggttaaag caaagtttcc ctagtagttc tatatataat cctagacaat 47160
ctactaatgg attaaaaggt aatattgaca atatggcttt aataatcggt tatggtgatg 47220
gaggtgtatc tagctaatga ataattttat accacaacct caagggttac ttaggttttt 47280
aaacgcccta gatacagatt taacttcttc tcatatgaat ttacttgatg aagaggtatc 47340
atttgtatct aaattttata caccgcaatt acaattaagt gaattagcaa aaaaagtatt 47400
gacaaatata aagacagatg atatacctgt attagaaaga gaatttaatg acaatacaat 47460
tattcataaa gctaacgata cattactaaa agtacaagcc cctagaatgt atatgattct 47520
acaatctatt gtacttgaag cgtatgctat tgttaattgc tttgtagaaa atccaagttc 47580
tttaaaatat ctaactgaag aagatgttag aataacacga gaaaatttaa attatgtagc 47640
agactattta ggtaactatg atgattacaa tagtgttgtc ttagatttac gagacctaga 47700
tttatgtttt agtgctatag agttacaatt acctctaatt aaaaaggagg ctaacgtata 47760
atgagattta agaagcatgt tgttcaacat gaagaaacta tgcaagcaat agcacagaga 47820
tactatggtg atgttagtta ttggatagac ctagtagaac ataataactt aaagtatcct 47880
tacctagtag aaactgatga agaaaaaatg aaagaccctg aaaggctagc ttctacaggt 47940
gatacattga ttatacctat tgaatcagac ttaacagatg tatcagcaaa ggaaattaat 48000
tctagagata aagatgtatt agttgagtta gctttaggaa gagatttaaa tattactgca 48060
gatgaaaagt attttaatga acacggtact agtgataaca tactggcatt tagtacaaat 48120
ggtaatgggg atttagatac tgtaaaaggc atagataata tgaaacagca gttacaagca 48180
cgtttattaa ctcctagagg ttctttaatg ttacacccta actatggctc agatttgcat 48240
aatttatttg gtcttaatat acctgaacaa gctacattaa tagaaatgga agtattgaga 48300
acattaacat cagataatag agtaaaatct gctaatctaa ttgattggaa aatacaaggt 48360
aatgtttatt caggtcaatt ttcagtggaa ataaaatctg ttgaagaatc aataaatttt 48420
gttttaggac aagatgagga aggaattttt gctttatttg aataggaaag gattaaatta 48480
tgaaaactag aaaattaact aacatattat caaaattaat agataagaca atggcaggta 48540
caagtaagat aacagatttt acccctggtt cagcctctag gtcattatta gaagctgtat 48600
cattagagat agagcaattt tatatcttga caaaagaaaa tattgattgg ggtatacaag 48660
aaggtattat tgaagctttt gatttccaaa agagacaatc taaaagagct tatggtgatg 48720
ttatcattca attttatcaa cctttagata tgagaatgta tatacctgca ggaacaactt 48780
ttacttcaac acgacaagaa taccctcagc aatttgaaac attagttgat tattatgcag 48840
agcctgactc tactgagatt gttgttgagg tttattgtaa agaaacagga gttgcaggta 48900
atgttcctga aggaacaatt aatactatag catcaggttc tagtttgatt agaagtgtta 48960
ataatgagta ttcttttaat acaggaacta aagaagaaag ccaagaagac tttaaacgta 49020
gatttcactc ttttgtagaa tctagaggta gagcaactaa taaatcggta agatatggag 49080
cattgcagat acctgatgta gaaggtgttt atgtttatga agaaacagga catattacag 49140
tatttgcaca tgatagaaat ggtaatttat cagatacttt aaaagaagat ataattgatg 49200
ctttacaaga ctatagaccg agtggtataa tgttagatgt tacaggtgta gaaaaagaag 49260
aagttaatgt ttctgctaca gtaactatat ctaataaatc tagaattggt gatacattgc 49320
aaaaacatat tgaaggtgtt attagaagct acttaaataa tttaaaaact tctgatgacc 49380
tgataattac agaccttatt caagctataa tgaatattga tgatgtatta atatatgatg 49440
tatcgtttga gaacttagat gagaacatta tagtaccacc acaaggaatt attagagcag 49500
gagaaataaa agtagaatta aagtaaagag aggtgaaact taagtcgtgg ctaatttttt 49560
aaagaatctt catccattat taagaagaga tagaaataaa aaagataatc aagaccctaa 49620
ctttgctctg atagatgcac tcaatgaaga gatgaatcaa gtagagaaag atgctataga 49680
aagcaagtta caatcttctc taaagacagc aacgagtgaa tatttagaca aatttggaga 49740
ttggtttggg gtttatagaa agaccgatga aaaagatgat gtttatagag caagaattat 49800
aaaatactta ctcttgaaaa gaggaactaa caatgctata atagatgcta taagagatta 49860
tttaggtaag gatgatattg atgtaagcgt gtatgaaccc tttaccaata ttttctatac 49920
taacaaatca tacttaaatg gtgaagacca tttaatggga tactattata gatttgctgt 49980
tataaatgtt tctataggtg actatttccc tatagagatt atagatgtaa ttaacgaatt 50040
taaacctgca ggtgtaacat tatatgttac ttatgatgga gcttctacta tcagaggtgg 50100
agcaattatt aagtggttag atggactacc taaaattgaa acatatcaag agtttgatag 50160
gtttacaggt tatgatgata cattttatgg tcatattaat atgaatcaaa gtaaagatac 50220
tgataatagt tcatcagaca tttttaaaac aaatcatagt ttaattaata gtttagatgt 50280
tttaacaggt tcctctagtg taggtagaca atatgttaac tatggatatg taacatcata 50340
tgtttataat ccaggtatga catcttctgt aaaccaaata agtgctagta cagaaggtag 50400
aggtcaggaa gtacctactg attattatat gtatactagt accaagaata ataatacagt 50460
agaacttaat atgcaaacta cttccggtgt atcttatctc tataataact ttaattttag 50520
agattatatg agtaagtata gacctcaagt agatttacaa tctgatgagg ctagaagaat 50580
tgtatctgat tatataaaag aattaagtat tgattattat ctcagtgctg ttatacctcc 50640
tgacgaaagt atagaaatta aattacaagt ttatgacttt tctattaata gatggcttac 50700
agtatcaatt agtaacttat ctttctatga aaaaaatatt ggtagcaata taggttatat 50760
aaaagattat ttaaatagtg aattaaatat gtttactaga ttagagataa atgcaggtaa 50820
aagagactca gtagatatta aagttaacta tctagattta atgttttatt actatgaacg 50880
aggaatttac acaataaaac cttataaagc attagtagaa aattacttag atatatctag 50940
agagacttat gtagaggcgt ttaaaatagc atcattattg aatggagaca ttataactaa 51000
aacaggtttc caacctatag gatacttaaa attagttggt agttatgaga atacaagacc 51060
tagcgcagta aacatagtag ctaaagatac agataataat cctatagaat ctactgagtt 51120
agatgtgtat agtacaatag aaaacaggaa tctattacag tcttataaag gtgtaaataa 51180
tatagctaga gaaataacat ctacggaaga gtttaccgta tcaggatggg ctaaagagat 51240
atattcaact aattatttgt ctaaagtact aaaaccaggt aaagtataca ctttatcttt 51300
cgatatggaa ataacaaata atgacctgac tcttaaatct tattctgata atcatggtat 51360
atatttatac agtaatacca aaggaattgt tgttaatggt gttaaatcta tggagcgcac 51420
cgtaggtaac aaagtatcta taactcagac ttttacagca cctactatta ccgaccacag 51480
gttattaatt tatactggaa gatatacatc tgatgggaaa gcatcaaccc ctccagtgtt 51540
ctttaataca gttaaaatta ctgaactaaa attatctgaa ggtgactcta aattagctta 51600
ctcacctgcc cctgaagata aacctaatgt aatagaaaaa ggaattcaat ttaataatat 51660
caaaactaat atacagactt taaatatcaa ttcagatatt aatctaaaga atgtaacttt 51720
atactattct tactatggtg atagttgggt agaattaaaa actataggta atattagtac 51780
aggagaaaca acagaaacta ataatttaat agatttatat ggattacaga cagtagatta 51840
ctctaacata aatccaatgt caaaagtatc attacgttct atttggaatg ttaaattagg 51900
tgaacttaat aatcaagaag gttctttatc taatatgcct aatgattatt ttaatgctgt 51960
atggcaagac atagataaac tatcagatat tgatttaggt tctatgagaa tggtcaaaga 52020
cactgaaggt ggagtatttg atggagctac aggtgaaatt attaaggcta ctttatttaa 52080
cgttggtgtt tatactgatt tagatatgtt agcttatact ttgactaatt acactgaacc 52140
attaacttta ggttctagta gattgataag tgagctaaaa gaagaattac taacatcaga 52200
atcatttaat gttgataata gaattaaagt aattgactca atctctgagc aattacctaa 52260
taataatata ttgagtaact cttatcaaac acaaacgatt acacagaatg gatttgctaa 52320
atataatttg aaagaaccta tagaacaaag aaaacaatac aacctaagaa tacatggaga 52380
ttttaaagaa ggactagaaa gattagctat aggtaattct aatgggtcat ttaatgaagt 52440
atttgtttat cctgaaaata ttaaagatgg tatagtagat attacttata cttctagaga 52500
tgataattat gcagaaggaa aacaaagact taataatgat tatagagttt atgctcaacc 52560
atatgatagt ggtgtagtta caatttacag tctagagtta ataaaagttt aataaataag 52620
ttgacagaaa gttaataata tggtatactt ataaagtaat atttagtggg tataccatgt 52680
tatattaata aagaaaacaa cagatgaaag gaattaaaaa aatatggcaa ttgcaacgta 52740
taattctcat gttgagttag caaaatatct agttagtaaa gctgattcag tttacttaac 52800
aattggaaag agcacaccgt ggtctaatga aacaaaccca ccgcaacctg atgaaaatgc 52860
aacagtatta caggaggtta ttggatacaa aaaagctact aaagttactt tagttagacc 52920
ttctaaatca cctgaagatg ataataagaa tttaatttct tatggtaata aatcgtgggt 52980
agaagtaaca cctgaaaatg ctaaggctga aggagctaaa tgggtttatt tagaaagtag 53040
tattgttggt gacgaactac ctcttggaac atatagacaa gtaggatttg ttatggactt 53100
agtagcaaaa agtggtatta gtaaatttaa cttagtaccg agtgaagtag aatcaattgg 53160
aacactatta ttctttgaca ataaacagtt ccaaaataga agtgagcaaa caactgctaa 53220
agaaagattt attgtagaag tttaaagaaa gggagataat tctaaatggc aattaatttt 53280
aaaggttcac cttatttaga tagatttgac ccgtctaaag atagaacaaa agtattattt 53340
aatcctgata gacctctaca acaggcagaa ttaaatgaaa tgcagtctat agaccaatat 53400
tatttaaaaa atctaggaga cgctattttt aaagacggag ataagcaatc aggacttgga 53460
ttcacattgt ctgaagataa tgtattgaca gtaaaccctg gttatgtata tatcaacggt 53520
aaaataagat attacgataa tgatgattca gttaaaataa ctggtgtagg taaagaaact 53580
atcggtatta agttaacaga acgtattgtt acacctgatg aagatgctag cctattagac 53640
caaactagtg gggtaccaag ttacttctcc aaaggtgcag atagattaga agaaaagatg 53700
tcattaacag ttaatgaccc tacttcagca actatttata ctttcatgga tggagattta 53760
tatatccaat caactaatgc tgaaatggat aaaatcaata aagtattagc tgaacgtact 53820
tacgatgagt caggttcata taaagtaaat ggttttgagt tattctcaga aggtaacgct 53880
gaggatgatg accacgtttc tgtagttgta gatgcaggta aagcatacgt aaaaggtttt 53940
aaagtagata aaccagtatc aacaagaatt agtgtaccta aatcttatga cctaggaaca 54000
gcagaaaacg aaagtactat atttaataag tctaataatt ctattagttt agctaatagc 54060
cctgtaaaag aaattagacg tgttacaggt caagtactta ttgaaaaaga acgagttaca 54120
agaggagctc aaggtgatgg tcaagacttt ctttcaaata acacagcatt tgaaattgta 54180
aaagtttgga ctgaaacaag tcctggagtt actacaaaag agtataaaca aggagaagac 54240
ttcagattaa cagatggtca aactattgac tggtcacctc aaggtcaaga accttcaggc 54300
ggtacctcat actatgtttc ttataaatat aataaacgta tggaagccgg taaagattat 54360
gaagtaacaa cacagggtga agggttaagt aagaaatggt acattaactt tacaccttca 54420
aatggagcta aacctattga ccaaacagta gtattagtag actatactta ctacctggct 54480
cgtaaagatt cagtgtttat taataagtat ggtgatattg caatactacc tggtgaacct 54540
aatattatga gattagtgac accaccgtta aatacagacc ctgagaattt acaattaggt 54600
acggttacag tattacctga ttcagatgaa gcagtatgta tttcgtttgc aatcactaga 54660
ttgtctatgg aagacttaca gaaagttaaa acaagagtag ataacttaga gtataaccaa 54720
gcagtaaatg ctctagatga tggtgctatg gaaggacaga accctttaac gctacgttca 54780
gtatttagtg aaggtttcat tagtcttgac aaagcagata ttacacatcc tgacttcgga 54840
attgtattta gttttgaaga cgcagaagct actctagcgt atacagaagc agttaaccaa 54900
cctaagatta ttactggaga tacaaccgct catatttggg gtagattaat ttcagcacca 54960
tttactgagg aacgtacaat ctatcaaggt caagcatcag aaacattaaa tgttaaccct 55020
tataatatcc ctaataaaca aggtgtactt aagttaacac ctagtgagga taactggatt 55080
gatactgaaa atgttacaat aactgaacaa aaaactaaga aagtaactat gaaacgattt 55140
tggagacaca acgaaagtta ctatggtgag actgaacatt acttgtattc taatttacaa 55200
ttagatgcag gacaaaagtg gaaaggtgaa acttacgctt acgatagaga gcatggacgt 55260
actggtactt tattagaatc aggaggacag cgtactctag aagaaatgat tgaattcatt 55320
agaattagag atgtatcctt cgaggttaaa ggtctaaacc ctaatgataa taacttatat 55380
ttattatttg atggtgtaag atgccctatt acccctgcaa ctggttacag aaaaggttct 55440
gaagatggaa ctattatgac agatgcaaaa ggaacagcta aaggtaaatt tactattcct 55500
gcaggtattc gttgtggtaa ccgagaagtt acactcaaga atgctaactc tacaagtgct 55560
acaacttaca cagctcaagg acgtaaaaaa atcgttcaag atattattat tagaactcgt 55620
gtaacagtaa acttagtaga cccattagca caatcattcc agtatgatga gaacagaact 55680
atatcatcac tagggttata ctttgcttct aaaggtgata aacaatctaa cgttgttatc 55740
caaattagag gtatgggtga ccaaggttat cctaataaaa caatctatgc agagacagtt 55800
atgaatgcag atgacattaa agtatctaat aatgctagtg ctgaaactag agtatacttt 55860
gatgacccta tgatggctga aggcggtaaa gaatacgcta ttgttattat tactgagaac 55920
agtgattata caatgtgggt aggtactaga actaagccta agattgataa acctaatgag 55980
gttatctcag gtaacccata tcttcaaggt gtgttattca gttcatcaaa cgcatcaaca 56040
tggactcctc atcaaaactc tgaccttaaa tttggtatct atacttctaa atttaatgaa 56100
acagcaacaa ttgaattcga accaattaaa gatgtatctg cagatagaat cgttcttatg 56160
tctacgtact taactcctga gagaacagga tgtacatggg aaatgaaatt aattctagat 56220
gatatggcat cttctacaac attcgaccag ttgaaatggg agcctatcgg taactatcaa 56280
gacttagatg ttttaggtct agcaagacaa gttaaactaa gagcaacttt tgaatcaaat 56340
agatatatct caccattaat gagttctagt gatttaacat tcactacatt cttaacagaa 56400
ttaacaggtt catatgttgg tagagctatt gatatgacag aggctcctta caatacaata 56460
agatttagtt atgaagcttt cttacctaaa ggtactaaag ttgttcctaa gtattctgca 56520
gacgatggaa aaacttggaa aacatttact aaatccccta caactactag agccaataat 56580
gagtttacac gctatgtcat tgacgagaaa gtaaaatcat caggaacaaa tactaaacta 56640
caagttagat tagatttatc aactgaaaat agctttttac gtcctcgtgt tcgtagactt 56700
atggttacta ctagggatga ataaactaga ggggttgatt gacccctctt tatttaataa 56760
ggagagattt atatgcctag agaagttaga gacccttatt ctcaagctaa gctatttata 56820
cctacagttg aagaaaaatc aattaaggaa ttagaaagaa catataagga aaaaattaat 56880
gaagttgata gacttcttaa tgaattaaag aaagagagag gagaaaaata gatggcattt 56940
aattacacgc ctcttactga aacacaaaag ttaaaagata tgtacccgaa ggtaaatgat 57000
attggtaact ttttaaaaac agaggttaac cttagtgatg taaaacagat atcacagcct 57060
gattttaata atattttatc atctatacct gatagcggta actattatgt aactaattca 57120
agaaatgctc ctgcaggaga agcaacagca ggatttgtaa gattagataa aagaaatgta 57180
aattattaca aaatatatta ttcaccttat agcagtaata aaatgtatat taagacttat 57240
gctaatggaa cagtatatga ttggattagt tttaaattag atgaaggtag tttatataat 57300
gagggtaata ctattaacgt caaagaactt actgaatcta caacacaata tgcaacacta 57360
gttaatcctc ctaaagagaa cttaaacact ggatgggtta attataaaga aagtaagaat 57420
ggtgtttctt ctttagtaga atttaatcca gttaactcta cttcaacttt taaaatgata 57480
agaaaactac cagtacaaga gcaaaaacct aacttactta gagatagttt atttgtttat 57540
cctgaaacaa gctcttctaa cattaaaacg gataattggg ctacacctcc attttgggga 57600
tatacagcta atagtggtcg ttcaggagtt agatttagag gagaaaacac tatacagatt 57660
gatgatggta atagcacata ccctacagca atgactaata gatttaaaat gggtaatgag 57720
ctttctgtag gggatactat aactgtatca gtatatgcta aaattaatga ccctgcttta 57780
cttaaagata acttagttta ttttgaactg gcaggatatg atactgtaga tagaacagat 57840
aatccttata caggtggtcg aagagaaata acagcaagtg aaataactac tgagtggaaa 57900
aagtattcat ttacatttac aatacctgaa aatacgattg gtgcgtcagg tgttaaagtt 57960
aattatgtgt cactactttt acgaatgaat tgttcttcta gtaaaggaaa tggtgcagta 58020
gtatattatg ctttacctaa attagagaaa tcatctaaag taactccgtt tattacacat 58080
gtaaacgatg ttcgtaaata tgatgagatt tggtctaatt ggcaggaagt tattagtaaa 58140
gatgaattaa agggtcattc ccctgtagac attgagtata atgattactt caagtaccaa 58200
tggtggaagt cagaagttaa tgagaaaaac ttaaaagatt tagctatgac tgtacctcaa 58260
ggctatcata ctttctattg tcaaggttct attgaaggga cacctaaagg acgctctatt 58320
agaggaacta tacaagtgga ttatgataaa ggtgaccctt atagagctaa taagtttgtt 58380
aagttattat ttacagatac agaaggtata ccatatacat tatattatgg tggttacaac 58440
caaggttgga agcctttaaa acagcaaaga acatctacaa tactttggga aggcactttg 58500
gattacggtt caaaagatac tattccttta aatgattcat ggactaacta tgacttatta 58560
gaagttgtat atctgactca atcatcggga cattataaaa caatgttttt agatttaaga 58620
atacctacga ctccgtattt atatataaga gattttannn nnnnnnnatt tatctaacaa 58680
ctctacaggt tcaggagtag acttctttga aggatattta actttcccta caaatacttc 58740
agcaacacca actatggtta aaaaggttac tttaaatggg tctactaata aaacatctgt 58800
aacagatttt aatgcacaag gaataataac tatatataga atagcaggaa ttaacacact 58860
ttaggaggtt agataaaatg gctagacaat ttgatattgg tagagacgaa atagtattac 58920
accttagaga tggtaaatat attacaggat ttacaacggc aggagcttat gatgaagact 58980
ttggtcaggt taaggttaat agagaaattt tacctgctta cttctttgat aactttgctc 59040
ttgatagata tctatactat aaaaaaccgg aagaggttat agagaataaa aactatgtac 59100
ctcctcaaat taataatagt gatgaggaat ctcaacaaaa tactgtacct aaagaacaat 59160
atgatagttt aaaagaagag ctagaactta tgagacagca acaagaagct atgatgaaaa 59220
tgcttcaaca actcttaggt caaaaggggt aataataaat ggcattaaat tttactacaa 59280
taacggaaaa caatgttatt agagacctga ctattcaggt caataacatt ggagaagaat 59340
taacaaaaga aagaaatata tttgacatta cggatgattt agtttataat tttaataaat 59400
cacaaaaagt taaattaaca gatgataagg gtttatctaa atcttatggg aatataactg 59460
taattaggga tataaaagaa ccaggttatt attatataaa tgcaagaaca ttagctacat 59520
tattagataa acctgatatg gaatcaatag atgttttact tcatgtacta cctttagatt 59580
catctactag agtagtacag catatatata cattgtctac taataacaat caaattaaga 59640
cattatatag gtttgtttcg ggaaactcta gttcagaatg gcagtttata actggattac 59700
ctagtaataa aaatgctgtt atttcaggaa ctaatatcct ggatatatct tcaccaggta 59760
tttactttgt tatgggaatg acaggaggaa tgccaaaagg tgtaagttcg ggatttttag 59820
atttgaatat agatgctaat gataatagat tagctaagtt aactgattct gaaacaggta 59880
aagaatacac tagtattaaa aaacctacag gtgtatacac agagtggaaa aaagaattag 59940
aacctcaaga tatgcaaaaa tatttattaa gtagtatcag ggatgatggt agtgcatctt 60000
tcccattact tgtgtacact agtgataata agacttttca acaggctgtt atagaccata 60060
tagatagaac agggcaaaca acctttacct tttatgttca aggtggtgtg acaggttctc 60120
ctatgtctaa tagctgtaga ggattattca tgtcagatac acctaataca tctagtttac 60180
atggtgttta taatgcagta ggtactgatg gtagaaatgt aacaggctca gtagtaggta 60240
gtagttggac ttttcctaaa acatcaccgt cacataaaga attatggacg ggagcacaat 60300
cattcttatc cacaggtact actaagaatt tagcagatga tattagtaat tattcttatg 60360
tagaagttta tactaaacat aagacatcag agaaaactaa aggtaatgat gatacaggta 60420
caatttgtca taaattttat ctagacggta gtggtaccta cgtttgctca ggtacatttg 60480
tatcaggaga tagaaccgat acaaaaccac caattacaga attttataga gtaggtgtat 60540
cctttaaagg ttcaacatgg actcttgtag atagcgcagt gcaaaatagt aaaactcaat 60600
atgttacaag aattataggt attaatatgc catagactag gaaacttatc ctagtctttt 60660
tttcttgact tgagaaggat tatgtgatat actataactc gtgtaaggat ataaggagat 60720
taaaatgaga ttaagaatta agaacttata tacctatgta gaatttgagg aggatgataa 60780
atacttaaaa gatatatttt taaagagagt tcatacgact ataggagcaa ggcaggaggg 60840
attccagtat agccctgctt acaaaagagg tagttgggat gggtatgtag acttttatgt 60900
ttatgaagaa gataaatttc ccactggact tttatttaag attgagttat tattagggga 60960
gttacaatca agatataact tccagtttga aacaattgat gagcgtgatg aaagtttctt 61020
agctgaggaa gatattgatg atgaaataac attacttgat aataatattg gtcaaattac 61080
tttaagagat taccaatatg aagcagtata taatagctta acattttaca atggtattgc 61140
tcacttagcc actaacggag gtaaaacgga agttgctagt ggtattatag accaactatt 61200
acctcagtta gaaaaaggag aaagagtagc atttttcaca ggctctacag agatattcca 61260
tcaatctgca gatagattaa gagaacgttt aaatattcct ataggtaaag ttggtgcagg 61320
taagtttgat gttaagcagg ttacagttgt aatgatacct acattgaatg caaaccttaa 61380
agaccctaca caaggggtta aggttacacc taaacaaaat attagtaaaa aaattgcaca 61440
agagatatta cctaaatttg aaggtggtac aaaccaaaag aaattattaa aagtattact 61500
tgataataca acacctaaaa caaaagtaga acaaaatgta ttaaatgttt tagaattaat 61560
ttaccaaaat agtaaaactg atgcagaggt cttgttaaac ttaaaaaaac ataatgcaca 61620
tttccaaaaa gttgttagag aaaagaatga aaagaaatat gataaatatc aagatatgag 61680
agacttttta gattcagtga ctgttatgat agttgatgaa gcacatcact ctaaatcaga 61740
ttcgtggtat aataatctaa tgacatgtga aaaagctttg tataggattg cattaacggg 61800
ttctatagat aaaaaagatg aattactatg gatgagattg caggctctat ttggtaatgt 61860
tattgcacga actactaata agtttttaat tgatgaaggt cattctgcta gaccaacaat 61920
aaatattata cctgtagcta atcctaatga catagataga attgatgatt acagggaagc 61980
ttatgataaa ggtataacaa ataatgattt tagaaataaa cttattgcaa aactaacaga 62040
aaagtggtat aatcaagata aagggacatt gattattgta aacttcatcg aacatggaga 62100
tacaatatca gaaatgttaa atgatttaga tgtagagcac tacttcttac atggagaaat 62160
agactctgaa actcgtagag aaaaattaaa tgatatgaga agtggtaagc ttaaagtaat 62220
gatagctaca tcacttattg atgagggtgt agatatatcc ggtattaatg cgctaatatt 62280
aggtgcagga ggtaaatcgt taagacaaac attacaacgt attggtcgtg cgttacgtaa 62340
gaagaaagac gataatacaa cacaaatatt tgattttaat gatatgacaa atagattttt 62400
atatactcat gctaatgagc gtaggaaaat ttatgaagag gaagattttg aaataaaaga 62460
cttaggaaaa taggagggta agagatggca acaagaacac aacgaaagtt ataccaatat 62520
ctagaagaaa atgctacaga aaataaattt catatttcta ctaagaaaga gttagcagat 62580
tctctaggcg tttccatctc tgctttatcc aataacctta aaaagttaga agaagaaaat 62640
aaagttgtta ctgtttctaa aagaggaaaa aatggtggag taataataac tttagttagg 62700
gaatatgaca cagaagaatt gaaagaattt aataattcta cagataatat cattacttct 62760
gatttacagt atgctaaagc attaagagaa aagcactttc cttcttatag atacgagagg 62820
aaagaacagc gtagacgtac taagttagaa atggcacagt ataatgctat taaagatgaa 62880
aagagaagaa ttatagcaga tatgaacttt cattcagaag gtcttcctta tccttctaaa 62940
gatatattta atatgtctta tgacccggaa ggattttata aagcatacat tctatgtaag 63000
ttatatgacc aatatgctat ttctcatatg gatgctaaac atacaagcca tcttaaagca 63060
atgagtaagg caacaactaa agatgaatat gattaccatc aacatatgtc tgaatactat 63120
agaaataaaa tgattcaaaa tttacctaga aatagtgtta gtgataattt cttcggtagt 63180
aaaatgttta atactttcta taatttttat ttaaaaataa aagataaaaa tattaatgta 63240
tttaaatata tgcaaaacgt atttaagaat gtaacatttt attatgagaa tggtatgcaa 63300
cctaatccaa taccttctcc taacttcttt agttcagata agtattttaa aaactataat 63360
aattatatta aaggaataaa aaaaggtgtt aatagtacaa atagacactt aggggataca 63420
gatagtatta ttaattcatc agattatgtt aagaaccctg ctgtattaca tttacatcaa 63480
ttatatacta caggattaaa ttctacttta catgatattg atactatgtt tgagcaagcc 63540
ttagaccttg agaatgcttc ttatggacta tttggagata tgaaacatat tattttacta 63600
caatataatt ctatgattga agaagaaatt aagaacttac ctacagaaga gaaaagtatt 63660
attaataaat atgtaaaaca atgcataatt aatgattact ccccaacaag catatcacca 63720
tctgcaagat tatcaatgtt tactatgcag aaagagcata tagtttataa taaacagtta 63780
aacagaggaa tcaagagaga agatttatta ccattaagtc taggaggtat agtgaataaa 63840
gattcactaa gtggtatgga tatacaaaac ttagagcaga atggtaatga gtacctatat 63900
atgagacaac atacttcaac ttattatata ctaagaatgt ttggtgatta tctaggatat 63960
gaagtaaact taagagaagt aaaatatatt gtagagaaat ataatttaat tgataaaata 64020
ccattgacaa aagagggtat gttggattat aataaactta tacatttagt agaggaagag 64080
gttaataact atgagtaaga agataaagga gcttatcctt cataaatcaa tgaaggatat 64140
acattttgca agagaagtac tagataactt acctaagaac ctattttcag cagaatctga 64200
agatatgggt tacttattta cagctataaa aagaacagca catatttccg ataagatgtc 64260
taatgaagca ttagcaatta aagtagaaca gcttatggga aataataagg aagatgaaga 64320
aaaagtaacc aagacattga cttacttaga agatttatat aaagtagatg ttaatgaaaa 64380
agatgaatct gttaattatg aaatagagaa atatattaaa acagaaatgt ctaaggaagt 64440
attagttaag tttattgcag aaaataaaca agaagactca gacaatttac atgaacttgt 64500
agataaatta aaacaaatag aagtaagtga tatttcagga ggtaacggag aatttattga 64560
tttcttcgaa gacactgaaa agaaacaaga attattaagt aatttagcta caaataaatt 64620
ctctacagga tttaactcta ttgataatca tattgaaggt ggtatagcaa gaggagaggt 64680
tggattaatt atagctccaa ctggtagagg taaatcatta atggcttcta acttagctaa 64740
aaattatgtg aagagtggat taagtgtttt atatattgca ttagaggaaa aaatggatag 64800
aatggtatta cgtgcagagc aacaaatggc aggagcagaa aaaagccaaa ttgtaaacca 64860
agacatgtct ttaaacagta aagtttatga tgcaatacaa aaccattatc agaagaatag 64920
aaagttacta ggtgactttt atatttctaa acatatgcca ggagaagtta caccaaacca 64980
actagagcaa attattgtta atacaacaat caagaaagat aagcatattg atgttgttat 65040
tattgactac cctcacttga tgagaaatcc atatgctaaa tatcactcag aatcagatgc 65100
aggaggaaaa ctgtttgaag atattcgtag attatcacag caatatgggt ttgtatgttg 65160
gactttagct cagaccaacc gtggagctta tggttcagat gttattacaa gtgagcatgt 65220
agaaggttct cgtaagattg tcaatgctgt tgaggtttct ctagcagtaa accaaaaaga 65280
tgaagaattc aagagtggtt tcctaagatt atacttagat aaaattcgta acagttctaa 65340
tacaggggaa cgatttgtta atcttaaggt agaaccaact aagatgattg taagagatga 65400
aacaccggaa gaaaaacaag aacatataca gctattatct gacaatggaa aagaagatac 65460
aagtaaattc caaaataaag ataataaaat agaagctata aataacacat tcggaggatt 65520
accgggagtt taaattttta ctatatacca cttgacattt tatatgttag gtggtataat 65580
tattttataa agaataaaag gagagattaa tatgaaaatt aaacaaatat tacctagtaa 65640
taatccaaac aaatatcacc ttttgattga gagcaagcta atacctagtt actactcaac 65700
aagagatgat gtttataatg attattatga tttaaatcta tatggtatgt ttgatgatag 65760
tgaaaattta ttatgttcat gtgcaataga aaagtataat gaattagtat ttatgaaaag 65820
gtttgttatg gttggggaac atggtaatgg atattttaaa cagatggttt ctcttataat 65880
aaaagaagaa cctcatatat gtttaactat aaataaagat aatattaaag tagctgatat 65940
cttaaatgaa ctaggattta ttaatgcagg agaagtaatt gatagaacag gaaagtatac 66000
ttatgaatta taccaaggag gaagagctta atgaagtttg tattttttac agatagtcat 66060
tttcatttat ttacaaacta tgcaaaacct gatgatgaat ttgtaaatga tagatttaaa 66120
gagcaaatag aagcattaca gaaagttttt gatattgcta ggaaagaaaa ggctaatgtt 66180
attttcggag gagatttatt ccacaaacgt aattcagtag atactagagt atataacaaa 66240
gtatttagta catttgctaa aaataaagat gtccctgtat tattacttcg aggtaatcat 66300
gatgctacaa ctaattcatt atataccgat tcaagtatag atacatttga gtatttatct 66360
aatgtaagtg taataaagtc attaaataca attttaaaag ataatgttaa tattgtattt 66420
acagcttatg gagatgaaac agaagaaata aaaacctaca ttaacagtaa ctatgataaa 66480
gatatggtta atatactagt aggtcatcta ggtgtagaag ggtcattaac tggtaaaggt 66540
tcccatagat tagaaggagc ctttggatat caggacttat tacctgataa atatgatttt 66600
attttactag gtcattatca tcgtagacaa tatttccaaa acccaaacca tttttatggg 66660
ggttcattaa tgcaacaatc attttctgat gaacaagaag ctaacggtgt tcacctaata 66720
gatacagaaa agatgaccac agaatttatt ccaattcata cacgtagatt tattactatc 66780
cagggagaag atatacctga aaactttgaa caattaatag aggaagataa ttttattaga 66840
gttattggta cctcaaacca tgctaaagtt ttagagatgg atgatagtat gaaggataaa 66900
aacgttgaag ttcaaattaa aaaagaatat actgtagaga aacgtataga tagtgatgta 66960
tctgatgacc ctctaacaat tgctagcact tatgctaagc aatactcacc tgaatcagaa 67020
caagaaatac ttgaatgttt gaaggaggtt ttatagtgag aaaatataaa gaatatctaa 67080
acaagtcaga tgaagaaaat ttagcagaag attgggaacg gataaaagaa gatttatgga 67140
aagtgtttaa agatatgaaa cctaaaatta atacattaga catcagtaat gtagtaagta 67200
aagacttaga taaaagtaag cctattttac aatttcaaga ttcagacaga gtaatagaga 67260
acatttgtaa tgttgaaggt ttagaagatg gtttatctaa aatgaaaaag atttttgacg 67320
atagtaattt tgaaaaacat tactataata gaattgtaga acatgatgaa tattattgga 67380
ttgattatgg ttctcatcat tgtttcttta gggttacgaa aggagataag taatggtcgt 67440
atttaaacaa gtagaagtta ataatttttt agcaattaaa gaggctacac tagagttaga 67500
taatagaggt ttaatactta ttgaaggtga aaataaatcc aatgagtcat tccattcaaa 67560
tggttccggt aagtcaactt taatatctgc cattacttat gctttatatg gtaaaactga 67620
aaaaggatta aaagcagatg atgtagtaaa taatattgag aagaaaaata catctgttaa 67680
acttaagttt gatattggag aagatagcta tttaattgaa cgttatcgta aagataaaga 67740
gaataagaac aaagtaaaat tatttgttaa tgataaagaa attacaggct caacaaatga 67800
tgttactgat aaacagatac aggatttatt tggtattgag tttaatacgt atgttaatgc 67860
tatcatgtat ggtcaaggag atattcctat gttctctcaa gcaacagata aagggaaaaa 67920
agaaattctt gaatctatta ccaagacaga cgtatataaa caagcacaag atgtagcaaa 67980
agagaaagtt aaagaagtag aggaacaaca gaataatcta agacacgaaa tagataaact 68040
aggatatcag ttatctacaa aagatgaata ctttcaaaag gaaattgaac agtataatca 68100
atataaagaa caattggctc aaatagaaaa tagtaataag gaaaaagata aattaaggga 68160
gcaagaggag aagcaaatag aagctcaaat agagcaatta acttcacaga taccaacaat 68220
acctgaagat gaatttaagc actcagagga gtataataaa gcttctcaaa gcctagattt 68280
actttctaat aaattaactg aactaaatca agtatatgca gagtataata ctaaagagca 68340
ggtactaaaa tctgaaatag ctacattaag taatagctta aatcaattag atacaaatga 68400
ccattgtccg gtttgtggtt ctcctataga taattctcat aaattaaaag agcaggaaaa 68460
tattaataat cagattgaga ataagaaaca agagattact agtgtactag aaattaaaga 68520
tacgtataaa gaagctattg ataaagtaaa taataaatca caagaaatta aagacaaaat 68580
gtctcaagaa gaccaacaag aacgagagca caacactagg attaataata tcattcaaga 68640
ggcttccaag attaaatcag atattagttc attagagaat aataaaactt atttaaaagt 68700
gaaatatcaa catcaatctg ttcaaggatt agaaagagaa gaaccaagta aaaagaaaca 68760
tgaagaagat aaaaaagaat tacaagaatc tattgacaaa catgaagaga atgtagtaca 68820
attagaaact aagaaaggta agtatcaaca agctgtagac gcttttagta ataaaggtat 68880
acgttcagta gtgttagact ttattacacc cttcttaaat gagaaagcca atgaatatct 68940
tcaaacttta tcaggttcag atattgaaat agagtttcaa actcaagtga agaatgctaa 69000
aggagaacta aaagataagt ttgatgttat tgttaaaaat agtaaaggtg gaggctcata 69060
taaatcaaac tcagcaggag aacaaaaacg tattgactta gcaattagtt ttgcaatcca 69120
ggatttaatt atgagtaagg atgagatatc tacaaatatt gcactttatg atgaatgttt 69180
tgatgggtta gacactatag ggtgtgaaaa tgtaattaag ttattaaagg atagacttaa 69240
tacagtagga actatatttg taattaccca taatacagaa cttaaaccac tgtttgagca 69300
aacaattaaa atagtaaaag aaaatggagt atcaaaactg gaggaaaaat aatgaaatta 69360
aagattttag atagagataa tgcaacactt aatgtgtttc atcgtaataa ggagcacaaa 69420
acgatagata atgtacctac tgctaactta gttgattggt atcctttaag taatgcttat 69480
gaatataagt taagtagaaa tggagagtat ttagaattaa aaaggctacg ttctacctta 69540
ccttcttctt atggcttaga ggataataac caagatatta ttagagataa taaccataga 69600
tgtaaaatag gatattggta taatcctgca gtacgtaaag ataatttaaa gattattgag 69660
aaagctaaac aatatggttt accggttata acagaagaat atgatgctaa tattgtagaa 69720
caagggttta gagacattgg agttatattc caaagtctta aaactattgt tgttactaga 69780
tacctagaag gtaaaacaga agaagaattg agaattttta acatgaaatc ggaagagtca 69840
caattaaatg aagcacttaa agagagtgat ttttcggtag atttaactta tagtgaccta 69900
gggcagattt ataatatgtt actattgatg aaaaaaatta gtaaatagta aggaaggata 69960
ttatgaggtt tgaagacttt ttaacccaag aattaggaga accaaaagaa aatactatag 70020
gtgaactaag atactgttgt ccgttttgcg gagaaaaaag ttataagttc tatgttaagc 70080
aagctttaga ctctagtaat ggtcagtatc actgtaaaaa atgtgatgaa tcaggtaatc 70140
ctattacatt tatgaagact tattataaca ttacaggtaa acaagctttt gatttattag 70200
agtctaagaa tatagatata gagagagccc ctttacttac aactaataat aaggatttaa 70260
cagaatcaga gaaacttata ttaatgctta gaggcgtaca ccaagataaa ggaaacacta 70320
atcttaaacc tcctagatta cctgagggat ataagttatt aaaagataac ttaaataata 70380
aagagattat acctttttta aaatacttaa aaggcagagg tataacttta gaacaaataa 70440
ttaataataa tataggttat gttattaatg ggtgcttcta taaagttgat ggagaatcaa 70500
aagtctcatt aaggaatagc attatatttt ttacgtatga taatgatgga aactaccagt 70560
actggaatac acgaagtata gagaagaacc cttatattaa atctatcaat gcccctgcta 70620
aacaagatga agtaggaaga aaagatgtca tatttaattt aaatatagca agaaagaaaa 70680
aattcttagt tataaccgag ggtgtctttg atgctttaac ctttcatgaa tatggagtag 70740
caacactagg taaacaagta acagaaaatc aaataaaaaa aataattgat tatgttagca 70800
tagatacatc aatatatatt atgttagata ctgatgcgtt agataataat atagatttag 70860
cttataagct aaaaacgcac tttaacaaag tttattttgt accgcatggt gatgaagatg 70920
caaatgatat gggaacaagg aaagcttttg agctattaaa acagaaccga gtactagtaa 70980
cacctgaaag tatacagagt tacaaaatac aacaaaaact taaactttag gcttgacctt 71040
agagaagttt tatgttatac taataattaa gtaattaata aaggagaaaa aataatgtca 71100
aataataaaa aagatatttt agaatttgta gatgaataca ttacagcttt aagagttggt 71160
aatgagcaac gacaacatca attagaagaa atgggtaaag aagaaacagc aacattaaca 71220
gatgtagcta aagctattac taaccttatg ttaggtgtta atgagcaaat gacagacttg 71280
gaatacaaca atgagttaaa tttaaatatt ttaattgacg ctttatataa agcagaactt 71340
attaatgaag atgtactaga ttacatccaa gaatcaattg ataaatcaca agaagaacct 71400
aaaaatgaag aagaaaaagg agaacaagaa taatggaaaa aaatattagc acacacacaa 71460
aaggtattag tcaagcagac atggagaaat ggattgaagc tgtagtccaa ggaactgttg 71520
atggtaaaca agttgatgaa aaaacagcta aacaactaga tagaattggt tcacgcagtg 71580
tttctttaga agaagcaact cgtattgcta aagtcattaa tgctgttaca gttcaagaga 71640
tgtcaggaga ttttaatgac gcatttaacg caattgactt aatgatgatt gttatggaag 71700
atgagttagg agtaactcaa gaacaagttg gaaaagctaa agataagtta aatgagaaac 71760
gagaagctta tttaaaagag aagcaagaag aattacgtca aaaacaacaa gaagagacac 71820
aaaaagaaac tgaatctgac agcaatgaaa aagtaattca gttgaagaaa aatgacgaac 71880
agtaagaaaa aaggagatac attcgaacgt aaaatagcta aagaattaac tgcttggtgg 71940
ggataccaat ttaataggtc tcctcaatca ggtggtgcct cttggggtaa agataataat 72000
gctgtcggag acatagtagt acctcaggaa gctaattttc ctttagtagt agaatgtaaa 72060
catagagaag aatggactat agataacgtt cttttaaaca atagagaacc acatacatgg 72120
tgggaacaag taattaatga tagtagcaag gtgaataaga caccttgctt aatatttact 72180
agaaacagag ctcagagtta cgttgcttta ccttatgatg agaaagtata tgaggactta 72240
agaaataatg aatatcctgt tatgagaaca gattttatta ttgataatat tagaaaagat 72300
aaattttttt atgatgtcct tataactacc atgaatgggt tgacctcatt tacaccttct 72360
tatattatat cttgctacga caaaaaagat ataaaaccat acaagaaggt tgagtctaat 72420
ttatctgagg taagtaagca tgaagatgaa ttgattaatg accttcttaa tgatatataa 72480
ggaagggtaa gataggtatg acaagtaaag aaagaccatt aattgtatat ttttcaggta 72540
cagggcagac agaaagacta gtaaacaaaa ttaatattaa taactcattt gaaacgttta 72600
gggttaagag tggaaaagag aaaataaata aaccttttat actaataaca ccgacttata 72660
tgaagggtgc aatacctaaa caaatagaaa gattcctaga aattaatggg agccctaagg 72720
aagtcattgg tacaggaaat aaacaatggg gctctaattt ctgtggagca agtaaaaaga 72780
tttcagagat gtttaagatt cctttaattg ctaaagtaga gcaatcagga cactttaacg 72840
agatacaacc aatattagaa cactttagta ataaatataa agtagcgtaa aggatgagag 72900
atatatggca acatatggaa aatggattga gttaaataat gaaataactc aattagatga 72960
caatggaaaa aataaactct ataaagacca agaagcttta gatgagtatt taaaatatat 73020
tgaagataat acaagaaagt ttaataatga agtagaaaga attagagtat tgacaaaaga 73080
aggaacatat gataaaatat ttgataaagt tcctgatact attattgatg aaatgactaa 73140
gctagcttac agttttaatt ttaaatttcc tagttttatg gcagggcaaa agttttatga 73200
gtcttacgca tcaaaacagt atgacgagaa taaaaaacct atttttgttg aagactatga 73260
gcaacataac gttcgagtag ctttatattt atttcaaaat gattatgtaa aggctagaga 73320
gttattagta caacttatgg agcaaacatt tcaaccatct acacctacgt ataataactc 73380
agggcaagct aatagaggtg aactaagttc atgttatcta tttgtagtag atgattcaat 73440
tgagtcctta aattttgttg aggatagtgt agctaatgct agttctaatg gtggcggagt 73500
tgcaattgat ttaactagaa ttagaccgaa aggtgctcca gtacgtaata gacctaattc 73560
aagtaaaggt gttattgctt ttgctaaagc tattgaacat aaagtaagta tatatgacca 73620
aggcggggtt cgacaaggta gtggtgcagt ctaccttaat atattccata atgatatttt 73680
ggatttatta agttctaaga aaataaatgc tagtgaatct gttagacttg ataaactatc 73740
tataggtgtt acaataccta ataagtttat ggaattagtt aaagaaggta aacctttcta 73800
cacgtttgac acttacgata ttaacaaagt atatggtaaa tatttagatg aattaaacat 73860
tgatgagtgg tacgaagaat tattaaataa tgataaaatt ggtaaagtaa aacatgatgc 73920
tagagaagtc atgacagata ttgctaaaac acaattagaa tcaggttacc cttatgtatt 73980
ttatattgat aatgctaatg acaatcaccc tcttaaaaat ctaggtaaag ttaaaatgag 74040
taacttatgt acagaaattt cacaattaca agaggtatca gaaatttatc catattccta 74100
tagtaatcag aatgttatta atagagatgt tgtttgtaca ttaggttcac ttaacttagt 74160
taatgtggtt gaaaaaggtt tattaaatga gtccgtagat attggtacaa gagcactaac 74220
aaaagttact gatattatgg atttaccata tctacctagt gttcaaaaag caaatgatga 74280
cattagagct atcggtttag gttcaatgaa tttacatgga cttttagcta agaatatgat 74340
tagttatggt tctagggaag ctctagacct agtaaacagt ttatatagtg ctattaactt 74400
ccagtctatt aagacatcta tgttaatggc taaagaaaca ggaaaaccat ttaaagggtt 74460
tgaaaagtct gattatgcta caggtgaata ctttgtaaga tatattagag agtctaacca 74520
acctaaaaca gataaagcta agaaagtcct aagcaaggtc tatattccaa cacaagatga 74580
ttgggatgaa ttagctaaag cagttaaagt atatggactg tataatgggt atagaaaagc 74640
agaagcacct actcaatcta tatcatatgt acagaatgct acaagctcaa ttatgcctgt 74700
acctagtgct atagagaaca gacaatatgg agacatggaa acatactatc caatgcctta 74760
tttaagtcct ataactcagt ttttctatga aggagaaaca gcttataaga ttgataataa 74820
acgtattatt aatacaagtg cagtagtgca aaaacataca gaccaagcag tatctactat 74880
actttatgta gaatcagaaa taccgactaa taagttagta tcattatatt actatgcttg 74940
ggaacaagga ttaaaatcat tatattatac acgttcacgt aaactttctg ttattgaatg 75000
tgaaacatgt tcggtttaga aaggaaatag atatggatat tacacaaaaa gtaaaacaac 75060
ataataaaaa tgcagtatta aaggcaacaa attggaatat tgaagatgac gggatgtctg 75120
atatttattg ggagcaagga atctcccaat tttggactcc tgaagagttt gatgtatcaa 75180
gagatttaag ttcttggaac agtttaactg agagtgaaaa gaacacttat aagaaagtcc 75240
ttgcagggct cacagggctc gatacgaagc aaggagggga aggtatgaac ttagtatctt 75300
atcatgaacc aagacccaaa taccaagctg tatttgcgtt tatgggtggt atggaagaga 75360
tacatgctaa atcttatagt catatcttta caacactatt aagtaataaa gaaacaagtt 75420
atttactaga tacttgggtt gaagaaaatg actttttaaa agtaaaagct cagtttattg 75480
gatattatta tgaccaatta ttaaaaccta atcctactgt atttgataga tatatggcta 75540
aagtagctag tgccttttta gaaagtgcat tattttactc aggattttat taccctttac 75600
ttcttgcagg aagagggcag atgacacaat caggagctat tatttataaa attacccaag 75660
atgaagctta tcacggttca gcagtaggat taacagctca atatgattac aatcttttaa 75720
cagaagaaga aaaaaaatta gcagatagag aaacttatga attattaaat attctttata 75780
ctaatgaagt agcgtataca catagtctat atgacccgct agagttaagt gaagatgtaa 75840
ttaactacgt tcagtataac tttaatagag ctcttcaaaa ccttggaaga gaagattatt 75900
ttaatcctga accttataac cctattgtag aaaatcaaac taatgtagac agattacgaa 75960
atgttgattt ctttagcggt aaagcagact acgaaaaatc tacaaacatt aaagatatta 76020
aagatgaaga tttctcattc ttagatagta aagagtatag tactgctaag gaattcctat 76080
aaaaaggaga aaagatatta tggatagaaa agaagcaatg gatttattaa gtaaaacaga 76140
aatattattt aaaaaacatg atgagttttc atgtgtgagt gatatcaatg accctatgaa 76200
gttatttagt aactctaaag atgccaaagc tgatgatacg tctaagtctt ttcagttaga 76260
gtttatgcat gatatgacta tgtatacttt atcttatggt tcaggacagt taaaactcat 76320
tgatttatca gaaggttatg aagcacaaaa agctacagca gttaactcat ttcccgaaat 76380
tattaaaaca ttagaaaagg atgattcaga agatggaaaa aatgaatagt ttagtagatt 76440
taaatacagc aattagacaa aagaaagatg ttattgtcat gattacacaa gataattgtg 76500
gtaagtgtga aatcttaaaa agtgtaatcc ctatgttcca ggattcagga gatattaaga 76560
aacctatttt aacacttaat ttagatgcag aagatgtaga tagagaaaag gctgttaagt 76620
tatttgatat tatgagtaca ccagtattaa ttgggtataa agacggtcag ttagttaaaa 76680
aatatgaaga ccaagttaca ccaatgcaat tacaagaatt agagtcactt taatttggaa 76740
tttcctacta tctgtgctat actataatag tacaaggtag taggattttt ttaatgaaag 76800
gaagatgaca tatcgcaaag aataaaacat taacgatata taatagtgat agatatttta 76860
atatacacac aaaagataaa gataaaatta atgaggctat taaagtcaca cacggtaatg 76920
aagaagaaat tgaaaagaat atggatgaac taatatctaa atctagacga tatattatga 76980
gagatgaaaa tcattatatg ttatttaatg agaaatacaa taatgatagg ctcatagaga 77040
aagtatgtaa acatggtggt aaagttacat actatactga ttcagtatta ccttattatg 77100
ttttaaaaga cttatctagt caccctgatt cagaagttgt ttatcgtatg cgtaacggct 77160
ttactgcaaa agaagtagat aatatagctt tatcatttat gggaacaaaa gttattattg 77220
atatttctgt ggtatttcct tatgtaaatc cttatgatat tattagaagt ttacatgata 77280
ttaaaacaaa tgtagatgaa gttcatttat catttcctcg tatattagaa gtagatgaaa 77340
aacaagaaaa attttatttc tttgatggtg aagcttatga tttaaaacct gaatataaag 77400
ttgattttgc agataaaatt agagtgtccc tatcagtatg gaaaatgtat atctatatct 77460
taacaagtag tcgtgatttt gaagatgtag acaatgtaat tacgaaacta aaacaacaac 77520
gaaagattaa gatataaggt gattatatga gtacagcaaa tagaagagat atagcaagga 77580
agatatcaga gaacacaggt tattatatac aagatgtaga agagatacta agtgcagaga 77640
cagatgctat ttctgactta ctagaagaag ggtatactaa agtaaagaat cataaattta 77700
tgcaaataga agttattgaa agaaaaggta aaaaagcttg ggatgggctg aataaagaat 77760
atttccattt acctaataga aaagctataa aatttaaacc acttaaagaa ttagaagagg 77820
ttattgatag acttaatgaa gaagagaaat aattctcttc tttttttatt gacaagattt 77880
aaaatatatg gtatagtatt attaagttaa aaaaggagag gaattaaatg aaagtattaa 77940
tcttatttga ccacattaga gaagaacatt tttctgtaag taaagatggg agtgtgaaat 78000
ctaatgtatt aaatacacct aatggaaaaa cacttaagaa attacttgag aagtgttcta 78060
acttaaagag agataaaaca aacagagact atgatattga ttttctctat aacgcagtac 78120
ctacacctat tagaaatgat tatggtaaaa ttattaaata ccaagatgtt aaacaagcag 78180
aagtaaaacc atattatgaa agaatgaata acattattat tgataactcc tatgatatga 78240
taattcctgt tggtaaacta ggtgttaaat acttattaaa tgttacagct ataggtaaag 78300
taagaggagt accaagtaaa gtaacaattg aaaatgaaat atcttctcat gatgtatggg 78360
tactacctac gtatagtatt gaatatacga atgtaaataa aaatagtgaa cgtcatgttg 78420
tatcagattt acaaacagta ggaaaatttg tagaacaagg tgaagaagca tttaaaccta 78480
aagaagtatc ttacgaatta gtagataaca ttgaaagagt aagggaaata tttaataagg 78540
aagtaaagaa tgataattat gatggtgtag atatcaccgc atgggactta gagactaact 78600
cattaaagcc tgataaggaa ggaagtaaac ctttagtatt atcactatca tggagaaatg 78660
gtcaaggtgt gactatacct ttatacaaat cggactttaa ttgggaaaat ggtcaagaag 78720
atattgatga agtactagaa ttacttaaga attggttagc tagtaaagaa gatattaagg 78780
tggcacataa tggtaaatat gatattaaat ttttaatgag tactgagaac tttaaagatt 78840
ttgagaacat tcaagatact aaagtaggtt ggtatttagc tgtcacacaa gaagttaaag 78900
aatctttgag attatctgac ttagcttacg aggtaacaga tgtcggaggt tatgataaac 78960
cactagaaga ttttaaatta tggtttgtta ctaagttatt aagatttttc tctgataaaa 79020
ttaaagaaat acagaaagaa aataaaaaaa ttgctaagaa agagtatgat gttaaagctc 79080
ctgaatacaa agagtggtta gagactaaat taaatgaaac aatagtagaa ttagatgata 79140
ctgagaagaa atttagagtt agtgaattag agaaaaaata cattcagtta ggtctttcac 79200
ctgaaattgt aaacatgaat ttagttatga acaacgatga atttattagt attgcagagc 79260
aatcacctga atatatggga ttatctgatt acgctaaatc ttacacactg aatactgcaa 79320
ttgatttaat taacaagtat agagatgtaa aagatgtaat taatgatatt gatggaggta 79380
actttaacta tgattggttc cctattgagt taatgcaccc gtacgcatca ggagacactg 79440
atgtatgtag aagaattcat tgtgatgttg ttaagaaact taaagagcaa gatagaccta 79500
agtcaatgca tttattagaa gttaattacc caagacttac taaatcatta gctagaattg 79560
aatcaaatgg tttatactgt gatttagatt acatgaaaga aaatgatgag tcatacgaat 79620
ctgagatggc taagaaccac gctactatga gagaacattg ggctgttaaa gaatttgaag 79680
agtatcaata taacctttac caaatggcgt tagaagagca tgagaaaaag ccaaaagata 79740
gagacaaaga gattcatcag tatagagata agtttaaaga tggtaaatgg atgttttctc 79800
ctagctcagg agaccataaa ggtagagtaa tttatgatat tttaggaatt cagttacctt 79860
atgataaaga gtatgttaaa gaaaaaccat ttaacgctaa tgttaaagaa gcagacctta 79920
cttggcagga ttataaaaca gataagaaag ctattggtta tgcattagat aacttagaat 79980
taaaagatga tgttaaagaa cttcttgaat tacttaaata tcatgctagt atgcagacaa 80040
aacgtaactc atttactaag aaattaccta atatgattaa taaacaaaaa cgaacattac 80100
atggttcttt ttctgagaca ggtacagaga catcaagatt aagtagtagt aatcctaact 80160
tacaaaactt acctgctcat acatcagatg taaacaagtt tgattataaa catccaatta 80220
aacgttcatt tgtttctaga tttgaaaatg gagtactact aggagccgac tatagtgccc 80280
tagagatgcg tattattgga ttatttacta aagaccctga tatgctacaa tcattcttaa 80340
atggtgagga tattcataag gctacggcaa gtattgttta taataaacca gtagaagaag 80400
taactaaaga agagagacaa gcaactaaag cagttaactt tgggctagcc tttggagaat 80460
caccattctc atttgcaggt aaaaataata tggaagtaag tgaagcagaa gaaatatttg 80520
aaaagtactt ccaaacaaaa cctagtgtaa aaacttctat tgacaatgta catgaatttg 80580
tgcaacaata tggttatgtt gatacaatgc acggtcatag aagatttata cgttcagcac 80640
aatcaacaga taaaaagata aaaaatgaag gtctaagaca atcatttaat actattatcc 80700
agggttcagg tagtttccta acaaatatgt ctttaactta cttagatgat tttattcagt 80760
ctcgtaactt gaaatcaaaa gttattgcta cagtacacga tagtatctta attgattgcc 80820
ctcctgaaga ggctaagatt atggctaaag tgacaattca tattatggag aatttaccgt 80880
ttgatttctt aaaagcagaa attgacggga aagaagtaca atacccaata gaagctgata 80940
tggaaattgg tttaaattat aatgatatgg ttgaatacga tgaagaagaa attgatacat 81000
ttaattctta ccaaggttat attaagtaca tgatgaattt acagacttta gaagattata 81060
aagagtcagg taaattaact gatgaacaat ttgaaaaagc tactaatgtt gttaaaagtg 81120
aaaaacatat ctatcaagaa atttaataaa agtattgaca atatgtttca cttatgttat 81180
actatatagg taataagtat aaggaggaaa aaagagtgaa tacaggagag attagattta 81240
atcgttctat ggatgaatgg attataacaa gtatgtacca ggatgaatta ggtgaaatga 81300
atattgttgt tacattctat aatagagaag aaaataaaca tggctctacc gttttaccaa 81360
cagagtcatc tactggagaa gtaacagaag aattagcaag tcttgaagaa gaatatcctt 81420
tagctttacc gttaagtagt atttcagtta atatttaaaa ggaggaactg ataaatggag 81480
atacacattg attccctaga ttttacaaat tttactatta aagatagaaa cgggaactca 81540
caagagtttg atattacaga tgaattaaag attacagaat atacaataca agaagatttt 81600
atgcaacaat cagctaagta cgctttttgg gcttctatat tagagaaggt cagagcatat 81660
tctgaaatgg agcaaagaaa tttagaaaca attggtagta agcttaatct cacaattaga 81720
caagagtatg aacaacaagg taaaaagcct actaaagata tgattgagtc tagtgtgtat 81780
attcatgatt cctatcaaca acaacttaaa gttgttgagg cttggaatta taaagttaaa 81840
caacttcaat atgttgtaaa agcttttgaa acaagaagag atatgatgat tcaattaggt 81900
gcagagttac gacaaacaaa taaaaatggt ggaattacta acccattttc acattaaaaa 81960
agaaagtaaa gaatataatt gacaaatata aaaaactatg ttataataaa taagtaaatt 82020
aattaaaagg agaaaagata attatggatt tcaatcaatt tattaacaat gaggcaagca 82080
aattagaaag taataacagt tcttttaaca acaatgtaga gagctataaa cctaaaaacc 82140
ctgtattacg attaggtaat attaaagatg caaatggaaa taaagttact aaagaaaatg 82200
cttttgtacg agtattacct cctgcacaag gaacaaatgt tttctttaaa gaatttagaa 82260
caacaggtat taactactct aagaaagatg gttctcaagg attcacagga ctaacattac 82320
ctgcagaacc aggttcatct gtccttgacc cttacattca ggactggata acaaatggcg 82380
ttcaatttag tagattccct aataaacctg gagtacgtta ttacattcat gttattgaat 82440
actttaataa taacggacaa attcaaccta aaacagatga gcaaggaaat gtaatgattc 82500
aacctatgga gttatcaaac acaggatata aagaattggt agcaaacctt aaggatacta 82560
tgttaaaacc gtcacctaat gcacctcata gttttatttc agcaaatgaa gcattcttag 82620
ttaatattgc taaagctaaa aaaggtgaaa tgtcatggaa agtaagtgtt tatcctaatg 82680
ctcctttagg tgcattacct caaggatggg aacaacaatt atcagactta gaacaattag 82740
caaaaccaac agaagaacaa aaccctaact ttgttaactt cttaatcaat aacgttaata 82800
acacagagtt aagtcatgat aactttaaat ttaaccgtga gtctaatgta ttaggtgaag 82860
aaccttcaga acctaaacaa gctcctactc aacaagatat tgatagtcag atgccaagta 82920
atattggagg tcaacctaac caaccacaac aaggtcaagt aggtcagtat actcaacaag 82980
gtcaaaataa tggtcaagga cagcagttac aaggtaacca acagccaatt agtaatactc 83040
aatttggtca aggaacacct tcaggacaac aacctaataa tacaggttca gttgattggg 83100
ataacttagc tcaacaacaa tcacaaccgg attcaaatcc ttttaatgac tttgatgtaa 83160
acagtgttga tgattcacaa gtaccttttg agacacaacc tcaaaacaca caacaagcac 83220
ctgaaccaca acaaactact caggagcctc caaaacaaaa acaaacacaa agtattgacg 83280
atgtattagg tggtctagac ttagataacc tataagatat agagtgcctt agagcactct 83340
tttatttgag atataattac taggaggata ttaaatggca agagcaaaaa aaggtaaaga 83400
agtagattta acagatttaa atacaattga tttaggtaaa gaattaggat taacattatt 83460
atcagataca aatagagcag atattaagaa tgttatacct acaatggtac ctcagtatga 83520
ctatatttta ggtggaggta taccgttagg tagattaaca gaggtttatg gtttaactgg 83580
tagtggtaaa tcaacatttg cagttcattt gtctaggatt gcaacacaat taggtgttat 83640
taccatttgg attgatattg aaggaacagc agacaataat cgtatggaac aacttggagt 83700
agatgtttca aaattattct ctattcaatc aggagaaggt agacttaaaa atacagtaga 83760
attatctgta gaggctgtag gtaaagaatt agagtactgg attgacacat ttaatgaaaa 83820
gatacctgga gtacctattg tgtttatttg ggactcacta ggagctacac gaactcagaa 83880
agagattgac ggcggtattg atgagaaaca aatgggtctt aaagcatcag ctactcaaaa 83940
agtaattaat gcagtaacac ctaaattaaa tgatacaaat acagggttaa ttgttattaa 84000
tcaagcacgt gacgatatga atgcaggtat gtatggtgac cctattaagt ctacaggtgg 84060
tagagcattt gaacatagtg ctagtttacg tattaaggtt cataaagcat cacaattaaa 84120
acaaaaaagt gaattaactg gtaaagatga atatcatggt catatcatgc gtattgaaac 84180
taagaaatct aaattatcga gaccgggaca aaaagcagaa gcagacttac tatctgatta 84240
tatggtaggt aaagaagatg accctatatt attaaatggt attgacttag aacatactgt 84300
atataaagaa gcagttgaaa gaggtttaat tactaaaggt gcatggagaa actatgttac 84360
attgaatggt gaagagatta aacttagaga tgctgaatgg gttcctgtat taaaagataa 84420
tagagagtta tatttagaat tattcagtag agtatatgga gagcatttcc ctaacggtta 84480
ctcaccattg cttaataata aagtaattgt aactcaacta gaagagtatc aagcccttga 84540
aaattactat aaagaatggg ctacagataa taaacaagag gaacaagagg aagaactaaa 84600
aggagaatct caagaaaagg attctgaata atagatggat aatttaatag ataaaaacat 84660
gaatcaggta aaagaatctt tggggaatgc aaattcctca gatgttcttc ctttacctta 84720
taaagatata gcaaagaaat ttgaagaagt aaaagaaaaa ggtgaatcaa ttatcattga 84780
agaaggtgga ttcccttaca cagattctac agtgatgtat atagaacatg taacagatag 84840
atgggcagga ggatactcct taattagaca tgaaggtgaa gaggttaaag tgcctaaaac 84900
tatccatttc tctgatatat atgttaagga taagtcacat aaagtaagaa taatcttcga 84960
gggggctaat ccttatgaag aaagctaaca atggtaatag atatgtaata gatatagatg 85020
gtattcctgt tgattttgaa agagacttgg atagtttact taacaggtat aaaaacctta 85080
gatggtcgtt gtatcataga tatgcaggta tattatctaa tgactttgaa agacaagaat 85140
taagagaata tattgatgag caatttatta aactagttaa agaatataat attagaagta 85200
aagtagattt tccagggtat attaaagcta aattaacttt gagagttcaa aatagttatg 85260
ttaaaaagaa tgaaaagtat aaacgtactg aaattatcgg taaaaaagat tatacggtag 85320
agtccttaac agaagattta aatgaggact ttgaggataa tcaaattatg agttatgtat 85380
ttgatgatat agaatttaca gaagttcaaa gtgagctact taaagaatta cttattaatc 85440
ctgaaagaga agatgatgcc tttatagttt ctcaagtagc ggagaagttt gatatgaaaa 85500
gaaaagaagt agcaagtgaa ttgacagaat taagagatta tgttagattt aaaataaatg 85560
catatcatga gtactacgca aagaaagaat taaataatca tagagttaat actgaaaatc 85620
atatttggga aaactagtta cagtgccttc cttgtgttat attattatcg agaattcaat 85680
aataaagcat agggaaggct tttttctatg tcttatagaa tgctttaaaa tagattacta 85740
aaataaagat tggagattaa gcttatggct aaaaagaatg ttaatgatgt attacaacaa 85800
gaatctgtta cagtagcaga taagtattta caagttaaag ttaaccgtga cggttatact 85860
cgtacacacg aaggacaata tgcgtacaaa gtagtttcag agggagaaga gttattctta 85920
tacccagtac aaacagatgg taaaggtaca ttaaatgtaa tgaagaaatc acctattgct 85980
tacactgatg gagacaatat ccattttgta gtaaatacag tagtagaccc ttataatcac 86040
tcatttatcc gtactgaaga tattaaagga ttagataaag gtaaacaact tattcaagct 86100
ttcttagctt tcgttgaaga ccgtttcaaa tttggtgttt ataacgtatt tgttgcaaat 86160
aacaaagaag atgtattatc tatcgtagac cctgcagata atgatgcaga tgaagttaaa 86220
gatagtttag agcatgcaca tgaagatgta attgcggatt tccctgctag ccctgctcgt 86280
aaggacgtta aaggcgtaga ttcaggagaa ggtcaaggag acacttcaga accatcagca 86340
cctaagaacg ttcaagttac tcctaaggaa gacggagcag acgtatcagc agaataatat 86400
agataaagga tggtaaattt ggctaagtta aatttataca aaggtaatga gttactaaac 86460
agcgtagaga aaacagaagg aaaatcaaca atcacgattg agaatttaga tgctaacaca 86520
gattacccta aaggtacttt taaagtatca ttctcaaatg attcaggaga atcagagaag 86580
gtcgatgtcc ctcagtttaa gacaaaagca attaaagtta tttcagttac ccttgacgtt 86640
gatagtttag accttacagt tggagatact caccaactat caacaactat cacgcctagt 86700
gaagcatcta acaaaaatgt gtcatttgaa tcagacaaat caggtgttgc tagtgtaaca 86760
tcagaaggat taattgaagc agttagtgca ggaacagcta atattactgt aactactgag 86820
gatggtagtc atactgatat tgttgcggta acagttaagg aacctattcc tgaagcacct 86880
acagatgtaa cagttgaacc tggtgaaaat agcgcagata ttactgcata ggaggacaat 86940
aaagaatgga aaagacatta aaagtttata gtaatggtga agttgtaggc tctcaagtag 87000
ctaataacga tggagctact acagtatcta ttacaggctt agaagccgga aaaacttatg 87060
ctaagggagc ttttaaagta gcatttgcta atgattcagg tgaatcagaa aaagtagatg 87120
ttcctgaatt tacaactaaa actcctgctg aagaaccttc agaagaagca taataattaa 87180
gaccaactaa aaagttggtc tttttttatt gacaatttat aatatctatg atacactata 87240
taagaattaa gaaaaggagg gaaagtaatg gatattccaa caatattatt tagaaatcca 87300
tatgattaca caaaagtaaa aaaattaatg gaaaacaaag aacagtacat tgtagtaaaa 87360
tttgattcag tttctgttca taatttaaat gttcaaggta tgatgaatgt tattcaagat 87420
tacctgcaca tctatggtta cagagtcaaa gaatacggac aagaaaatgc ttctaaagat 87480
gatgaaagag acgttaaagg ttacttatac gaaagagtag gtgagtaagg tatgggtgtt 87540
ataataaatt ctaaccatat tcagtcagat actttatatg agtacgatag tttttttgat 87600
attgagaaag tagatacgtt tgaagaagga ttactatcaa tacaggatga accaactgtt 87660
ttagcaggat ttatctatga tgatattaca tttaataagg ttattaactc taattcaaat 87720
attgataaca atattaagaa taatgatatt tattatgttt ctgatatagg gttacttccg 87780
gatactttta tcactgttga ttctaataaa aaatactatt cattattaca gcagatagtt 87840
gagttaagta aagacccttt ccctaaatgg gtagaaacgg atgcaaaaga tttaactagg 87900
tattataact ttcaagattt tgaagatgta ttcgatttaa atagttttta taaaaaagaa 87960
gttgacatgg taagagaaaa gtgctataat aatggtaatg tatatttatt atatgaagtc 88020
ttgcctgatt ataaattacc tctagcttat agtttacttt caaataaaga gcatggtatt 88080
gttattatcg gttcacagac acgttctaat aatgatatac tgacttttta cgttaaaggt 88140
atggatgcta aggcaatagc tagcatgttt aatgtagaac atgattatga ttctaatatt 88200
tttcatacat tcgtaaatag tcacattaat attttaggaa atcaaataac taagtttata 88260
agagagaaag gaagcagtta tgagtaacta taaaacaata gaagaagtac aagcagttat 88320
tatcggagta ttatttaaag atgaaggtaa aattgtaaca tctaagttta ataaaattac 88380
taaagagttt ggtttagata gaattggtaa agacgacctt aaagaaattg ttgaagatat 88440
tagacaagat gcctatctaa atgagcttaa gaataaagca attaaaggta aggtaacttt 88500
aggagacctt aaagatgttg cagataatca agtattcgaa ggtaataact atcatgaaga 88560
agtctctact tatgtagtag ctaaagaaaa agaactatct cacttgagag aacaacgtaa 88620
gcacaacaga cataccgcat accctcaaat tatgtttgat gaacttaaag aacatatggt 88680
taaagaatta caaggggaaa cattagtaga gcatcatgga agtaaagtta acattaatga 88740
tacagagtta attgtattac tatcagattt ccatattgga agtattgtat ccgatatgac 88800
taatggtaaa tatgattttg aagtattgaa gtcaagacta aatcacttta ttgatacgac 88860
agttaaagag attgaggata gagagatttc taatgtaact gtttactttg ttggagactt 88920
agtagaacat attaatatga gagacgttaa ccaggcattt gaaacagagt ttactttagc 88980
agaacaaatc tctaaaggta ctcgattact tattgatatc ttaaatgtac tatctaatgt 89040
agttacagga gaattaagat ttggtattat tggtggtaat catgaccgta tgcaaggtaa 89100
caaaaatcag aagatttata atgataatat tgcttatgta gtactagact ctttattgct 89160
attccaagag cagggattat taaacggtat agatattatt gataatcgtg aagatattta 89220
tactattagg gataatttcg gaggtaaatc tattatcgtt aaccacggtg atggattaaa 89280
aggtaaaggc aatcatatta ataaatttat cttagatagc catattgatt tactaattac 89340
aggtcacgta caccatttct cagtaaaaca agaagatttt aatagaatgc atattgtagc 89400
ttcatctccg atgggatata ataattatgc taaagagcta catttatcaa aaactaaacc 89460
ttcacagcaa ttattatttg taaataaaga aaataaagat attgatatta aaacagtatt 89520
tttagattaa ggatggttaa taaatggata caatttttat tataggtgta gcgtttataa 89580
cttttgcaac atttaatata gtctttagat tatttgattt atggactaca gagaagaaaa 89640
tggtaagtca aggacaacct ccactaagta attttgagta ctatcatgtg atagtaccct 89700
acttagttgg tgttattgtt attatactga gtattatttt tagagattcc ttgtattctg 89760
cgcaatcagg attcggtgtt attattacaa gctttattta tatgctagtt tatgttataa 89820
tcggtcttgt agggtcgttt gtacttacaa tattccaagc tagaaaggct agacagtatc 89880
aaacacagga ggataataat gaagttcaat gatatttatg agcaattaat taaaaatgat 89940
acaatacaaa acattcatga atctcaagat gatgaaggaa atatttatac aatacaattt 90000
gataaaggta atgataagta tttatttaat gttatcaatg atggattctt gaaagaaatg 90060
acaaatggta tggtagacca tcctaaaggt caaccatatt cagtaagtct aatcaataaa 90120
gaaactccta gtatgtcagt gaaacaatat ttaacagacg tagaagatat tgtacctact 90180
attagaaaaa tggaaaagga tttcttatag agtcaagtct ttacttgact ctttttacta 90240
tatatggtat attaatatag aggtgactta aaaatggatt ttaattttag tgcttttgat 90300
aatagctcat tagcaatgag aattagtgag ggtgtatact atttcaatga taccccttat 90360
tactttattg aacatataga agaagaaatg tctgagtatg ttattgtgta tgacatacat 90420
gatagagagg aaaaagaaaa tcctcagaag aaatatagag tagaacctta ccaacggaca 90480
atacctggag gtacacctct tagtaatttg attaagagta tgatgcctca acgtaaatat 90540
cctaagaagg ttgtagaaga ccctatattt gtagctaatg ttattccttt aggaacagat 90600
acagttacag gtaaaactgg aaaaggtttt tttgaaagag ataaggatag aactatttac 90660
tcacagaaag aaccaactaa ggtagtccat ggtcaataca caggtgtttt cataggtcta 90720
acaagtgtta aatggaatag aacatatact cctttagaaa gtgttgttga gtattgcaag 90780
agagtaaaag gagataggtt aaatgtctaa tgatgtagtt aagttttatg aaaaagatat 90840
taaagacctt ataagaacta aaaaacacat gtttaaagac gatgagataa ctagtgatat 90900
aaatgatata cgtatattta atgagaaagt aatttgtcaa ggtaagtgta gaacagattg 90960
cttagtacta gaccgtaatg gtactgtcat gggtatagaa ataaaaacgg aaagagattc 91020
tacacagaga ttaaataacc aattaaaata ttatagtcta gtatgtaagt atgtatatgt 91080
aatgtgccat gataaacatg tacctaaagt agagcagata cttaaaagat ataaacataa 91140
tcatgtaggt ataatgagtt acattaattt taaaggtaaa cctgttgtag gtaaatataa 91200
agatgctaca ccatcaccac atagaagccc ttatcataca atgaatatac tatggaagac 91260
aaatttaatg acaatactta ggttgattag agaccctcat acttatagaa cagggtatag 91320
ttataatgct agcggtaggt atagtggtgg ggaaggcaac ttctctcaaa caactcaaag 91380
taaaagaatg aaaaaacctg ctattattaa ccaaataatt cattatgtag gggtagataa 91440
tacttataaa ctctttacaa gaggtgttat ttatggttat aataatagat gggaagttat 91500
agaagaagat ttctttaata ctatgaaaaa tggggtaaga gtaatcaatg agcaaagaca 91560
aaccaaatag acgtaaagag atacagcatc aacctgttaa ctttgcccca acaaatactt 91620
taacaggagc taataatagt ttctttgcta aaaagccctc agaacctaag gatacaacat 91680
ctgttattga atatagaata ctttttatta aaagatttga taatgtaaca agtacagatg 91740
ttaagttaca aaaaaaatat gcattaaatc ttattagtga ggcacttgat gttaaagaaa 91800
cttatctatc tcttaaacaa aaaggaaaga aaacagaatc tattttacac acagatagag 91860
tttattatgt gcatagaggt aaaaaactta ttggaaaatg tagtattagg gagcaaagaa 91920
catttaaagg taaacatttg atatttatat ttaagacaag acatagagtt aaagcagaaa 91980
ggaaagataa ataatgttaa aaggattttc agaacatgta gataaaccta caactattaa 92040
aaccttatat aagaccttaa caagtggtaa agtagaatta ctaggtgtat cttatggtag 92100
tgattacttc ccttcaggtg ttacagtaca agcttatatt gaagatatag gtaatgaaga 92160
tgaaggtctg cagtttgtta ataaagtaaa cgtagtggaa tcaatgaaac aggctgtagt 92220
aggtatgaac aatcaattag gttcctcagg tcttggatat gttagaactg aacaacttaa 92280
aaaagagcta gaagaaactg gattaatgac agatttactt gctagaggta ctaacttaac 92340
ttctactaag aaagtggata ttgtaagtac ttttattgag cctgaagtaa catatcaaga 92400
cattactata gctaaagata ttaagttacg tctatacaaa ctagaagaag agtcaccatt 92460
aaacggttat acacatattg tatatcttct tactacagag aaattatatg atggtcaaac 92520
actatttggt atgctatcta agaaagataa gttatctaaa ggagatactg ataaattatt 92580
agcattcttt agaaataata gtttaataag taaaagtgta ttttgtgtta agttattaag 92640
taaagactac tacttcaatt tatataatac acatgaaaca ggtatattct ttttagaaga 92700
tacggatatt attactattg cttgtggtca gtcatacgtt aaagttaata ctaaagatat 92760
taaatctagt catgttaaaa ttgaagatga gactcataaa ttaactgagc tagtaattaa 92820
cttaaaaggt gacgacacat taactatttt attctaatag aatgttataa atatgtgata 92880
attaagtata aatatacgtt atatagaaag ttttcataat gtttttaata cagaaactag 92940
ttaagttttt tacacttgtc ctagtttctg tgaaattata tttatgaaaa gttaaaatat 93000
cttttaggta aaggctttgt aaatagttaa aaaatatatt aaaattttat acaaagtagt 93060
taataaaatt atattacatt tatatattat gaaataataa cagaaattgt gatatattat 93120
atagtgtaac cttgaaacag ttgatgttgt agggtttgtt tatgttcgtt aaactggttt 93180
cagaacatca gttaccataa ataaatgaca gttaaggaga gctatataat ggctagaaaa 93240
aagaatttac gaaataaaaa cagtgatata aaagttgttc ctgataaaga aaaagaaagt 93300
atattatcta agctatacca taataaatta ctacgctcaa aggtagataa tgctttagat 93360
gaagatatga gttatgatga tattatagaa ctatgtaaag aatatgattt agaattgtct 93420
aaatcagcta ttacaagata caaaagtaaa agaaaagaag ctattgaaaa tggttgggat 93480
ttaggagaat taattgataa acgtaaaaaa acaagcgtaa aagatattaa ggaaaaagaa 93540
actcctatat tagaagagga gcaactttct ccatttgaac aatcaaaaca tcacacacaa 93600
acaatctatg atgatattca agtactagat atgattattt ctaaaggtgc aaaaggatta 93660
gaatttgtgg aaactttaga ccctgcttta atgatacgtg caatggaaac taaagataag 93720
attaccggaa accaattaaa aggtatgtca tttattggac ttagagaatt acaattaaaa 93780
caaacagctc aagatacggc tatgagtgaa gtattattag agtttatacc tgaagaaaaa 93840
catgaagagg tattacaacg attagaagaa ctacaaaatg aattctacaa aaatctagat 93900
ttagatgaag aaagtagaaa attaaaagaa gctcttgata gagtaggcta tacaatttag 93960
atagtgaggt tagagtaatg gcagatgaga ttagtttaaa tccaatacaa gatgctaagc 94020
caattgatga tatagtagat atcatgacat acttaaaaaa cggaaaagta ctgagagtta 94080
aacaagacaa ccaaggggat atccttgtta gaatgagtcc agggaaacat aaatttactg 94140
aagtatctag agacttggat aaagaatcat tctactataa aagacattgg gttctctata 94200
atgtatctgt taactctctt ataacatttg atgtttacct agatgaagaa tactcagaaa 94260
caactaaggt taagtatcct aaagatacta ttgtagaata tacaagagaa gaccaagaaa 94320
aagatgttgc tatgattaaa gaaatactta cagataataa tggtaattat ttctatgcac 94380
ttacaggaga aacaatgctc tttgatgaaa ataaattaaa taaagttaaa gattagggtt 94440
gacagttctg aaagtatatg atatagtata tgtatactaa aaataaagga gctaacaatt 94500
atgtttattt cattaaatca agaagagaaa gaattattaa ctaaagagga aaacaagtat 94560
acaccattag aaacatcaag agagtttaac acacctaaag aagaattcat tgtaacaagt 94620
tataatgaag gtaaaccttt agattacatt gcaaaagaag ctaaagtaag tatgggatta 94680
atttacacag tcttaaacta ctataaagta ggtaagcgta acaagaaatc acctgtagaa 94740
gaaagaattg cacatatctt gaaagacaaa aacttagtta aagagattat taaggattac 94800
cagtatatga atttacagga catttatagt aaatataatc ttcataagaa tggtttatat 94860
tacatcttgg atttatacca tgtggaaaga aaatctgaac ttaaggacaa agcattggaa 94920
gaggataata ttgtcgttga gtaagtaaag aggttataat atgagaaata aaaaatcatt 94980
tcaagagcaa ttaaatgaca tgcgtaataa agagaaatgg gtatctgaag aggagttcac 95040
tgaagaagtg actccttctg aagaacctga agtagaagaa gaaaagttat atactttaaa 95100
tgagttaaaa gaaaatttat tggatgctca gggattaaaa gatgttgtcg ataattttcc 95160
tgcatctaag ccagtatatg aatctaataa gctttatatt tgtacaatac caaaaggata 95220
tcgttctaca gaagtacaac caggtcaata tattggtatc agtacagggt tattatcaga 95280
atcagaagat tttagtcatt taagaggtca aatgcctaga aatctttatg aaacttctca 95340
tgttttaaaa cctttagtac gtattaataa tacaaatctc gaatatcaac agcatgagtt 95400
acttgaagat attaaagatg acaagaagat atatgatgtt gaattagaag acctgaggtt 95460
agtaacagga gaagaaatat cccatttaga aattgtcgat agtaagtttt ttgaaagtcg 95520
tattaatgaa attctcgacc gctatactga attaacggat tccgatgatt tgcttatata 95580
ctatagtaaa ttacgagaat tagtaggcag tgacaaaatg atttattgct cacttctaga 95640
taaatgtgtt aaaattatag attaatagtt agtctcctct tatattataa ctgtaagagg 95700
agacattttt tatagaggtg ttaattatgt caagaaaagc aagtatattc tatatactag 95760
tagttattgt tttggctttt tctatttcat cttattatat atcttctttc atgtatcacg 95820
acaaagcaaa gaatgaagtc tctactgagt tatcaaacac gggaaagatt aaagaagaaa 95880
agaacgtaga atttgtcggt gactatacac ttaaaaaagt ggaaaataat aaagcttact 95940
ttatggaaac attacctact tacctacccg gtagaacagg agataacagc atagatatga 96000
ggtactacaa aacaagtaga tttaaagaag gggtaaattt caagcttatt agggtatata 96060
ctgaagatgg ggaagataat ccaattcata agtataggtt tgaagcagta ccaaccaaaa 96120
agtaataagg aggtgactta aatgacaaca ttaattgtcg tcatctttat tgctatcatt 96180
tattacttat ggaacagtga ttgagtcaag ttaattcttg actctctttt tgttttatgg 96240
tatattaata tatagaaagg agagattaat tatggaaatg gcagatttag aaagatttga 96300
tacgtttgta agattagttt cagacgatga gctttcggag gaaagaatat tagaattgag 96360
tgtagactta ttaaatccga tactagaagg aggtacagct taccaagcta aaaaacgcat 96420
tagaagtaag ttcggtaaaa tagaagcaaa aaactttaaa agaaattata aattcttact 96480
caagtcgata gctcaaatag accaagggag ataggacaat gacagaaagg gaaaagttag 96540
ttaaagagat tgaagatgct aatagggaca tacaattaag gttaaaagaa gtagatgatt 96600
ataaggatag tatacgttct aaaggaacaa gaaactatgt atctactaag gtattagatt 96660
cagttatggt agggctaatt ataagtttct ttattcttgt aatgttacgt gtacttgaat 96720
attttgtaac aggtaatgct gtttattcac ctttagcgcc tgcagttatt attatgtttg 96780
ttttagcctt aggtacatgg aaagtaagta aaatgaataa aatagtatcc tacaggggaa 96840
ctattaaaat gtattgggaa ttaagtaatg ctgagcagaa ccaagctaag atatttaagt 96900
atcctaatga tgaagtagat atcgtatcaa aacataactt aagacaaata acttttagtg 96960
agattaatat ccttcatctt aaatatatga gatataataa ggcagtagaa cagcatacta 97020
agttatctaa agaacttttt aaaaaagata aagaaactat tgacaagaac aaataagtgt 97080
agtatagtat tactaaagga ggagagatat tatggttata cctagtatta aagcacaaaa 97140
taaattcaag aatgaattag agtattataa gcaaggtcac attagtgaaa gtaaaatgtt 97200
agaattagct tttgattaca ttcaagaatt agaacaaaat aatgaatatg ttactaattt 97260
gctagaagag gagagatatg gtgagtaaat ttatcggagt gtacttattt aatttattag 97320
tagtagcgct aatttataca gtaggatttt tattctttta tggtgtagct agtttagtta 97380
ttattataac tcatgccact attgacccat ttgtattagc tactttctta ggaataggat 97440
tcttggttat tagaactgca cacagaatca tggcacgagt aatcaatgat gcagtagccc 97500
aagccattaa ggataaagaa aatgaataaa ggggaattta ttatggataa aacattacca 97560
aagtttagtg tatatgaagt tattgtaaag actgtaatta tgacaccaac agaaggaagt 97620
tctgaccgag aatcatttta cttttcaact caagagttag cagaaagatt tgttaaagaa 97680
aaccaagtag aaacaaaaga tggaaagcgt gtatcttttt ctattaaaga gcgtaaagta 97740
aatcaaccag gctaacatta atttgttagc tttttttatt gacaaatcat tttatatagt 97800
gtatagtaat attatactga aaaggaggaa ttattatgaa agtttcagaa gaagtaaaac 97860
agagctactt agagaataaa gctaatacta aaatggataa gataagttgg tctgagttaa 97920
ggtctagtcc tgcaggtaga acattaggag acttaatata ctttagtgta gttataataa 97980
ataatatcat agctatagca ttaacattaa tgcttggaga tattatcaaa gatttaacgg 98040
atagtaccct agtaaaaata ataagtatat tacttattat catcgttgta tacggtatac 98100
tatcggcttt aatacctata ctaatattta aatctgtatt tcctggatgg gaatatactg 98160
aatggaataa ttcttactat ttgagattac ctggagaaaa agattataaa tactatagct 98220
actggtattt aaatttatta ggtgttactg agttttatcg gacaaatgat gagggtaaag 98280
aaattaaaga aactagttta agttgggttt tttatactaa ggttgataga cctgaggata 98340
ttgaccattg gaaaaatcaa ttaataacta atagaccttt aacaatttct gagtacaaaa 98400
aactaaagaa gctagataaa gaaagtgaaa ttagaaaaca agaagattta gaagaataca 98460
agcaatacaa tagtaattaa agaggtgaaa aaccaatgat aagttcattt gatagtgtat 98520
tacttgtaat atacattatt atagcttttg cagtagctat ggcaatactt tatttagtat 98580
ttaaaggtat gaccctttta ttagataaac taatgatgtt attactaagt aaaactacct 98640
tagatgtaga agcttgctcc atgataatgg cagtagtcag tacaattgtg tttggaatta 98700
ttgtactttt aatatggtta gcagtaaata atattttatt gtaaggagtt ttactatgga 98760
ttttaatgac tttataaaca gtgaatcaga tagagtgggt aaacctaaac aaaagaagaa 98820
ggtagaaaat aaactacctt cttctactcc tattgaagag aaggaaaaaa tgttgaaaag 98880
aataagagaa aaatcattat acattgattt aaggagaaaa agaaatgact aaagaaacaa 98940
atgtacttta caaagataag tatagagatt atactatagt tgtaagacta gtaggtaata 99000
ttattgttac tgaagtagat aagaagcata aaacaaaatt ttcacctatt atatttgata 99060
atggtcgaga aggtgtagag cttgtaatgc gtatcggctc agaagaactt gatatgaaag 99120
aacttagaga atttactaaa gaggtatcaa cagctcagaa agctttagaa tattttaata 99180
aaaaacttta cattaaaggc ttgacagatg aagcctttta atatatacta agattataac 99240
taaaacaaag aaaagaggaa tgattattat gttattagga attttatggt ttatatgggg 99300
atttgtatct tattttgtag tgatgtttgg aattgaattt tggaaagaca gatggttacc 99360
aggagttatt ggtgcaggag ttttattaat attcttattt tggattatga agtctattca 99420
taatgctatg acagtagttt acttgtatta ggaggtaata tagatgaata tattagttat 99480
ccattatgaa gaaacaaata aacgagttct aaaagaaaca ataaaaacaa tacaaaatca 99540
tttaaacgat gaacatggtt tggttaaaat gacagcaaca agacttagta gaaaagccat 99600
agaagaagag tttaatgatt acaatatagt tattgcagaa aatgaccctg atagttttta 99660
cagctactca gatgcagtag acgatgtaga ttttgttata gatataccaa tttcatattt 99720
agatatacat gcaggtgtag agtgggatgt tgataatcct gtagatatgc tagataggaa 99780
ccctgatttt atagaagcta tgggtcaatt aaacgaggac ttaatgttat aaggaggaaa 99840
taaaatgtta aatgaaaaac taaaaaattt agaagatacg aaagtgtata tgattaatag 99900
tattgcaagt ttactaagtg caagtacagg taaatcaagt aaagtatttt ttgatgaagg 99960
aactattaaa attgtaagtg gtgatacaaa agcggtagaa gttattgata atttagttca 100020
ccctcattca ggacgtttac ctattaaaac aacagaacgt attgctcttg gtagactaac 100080
agattcttta cagtttgtta tttcagaaat agagtcggtt aaagaccaaa ttatagatga 100140
agaaaatgaa gcttacattg attttgtaat ggaagactgg aattgggatt aatgcctatg 100200
gacttaatga caatagcttc tgttgccttt atagctgtcg ttattattga tttaattaat 100260
gatgatatga gctatatgtt aactggtact gcaatattaa taaacatttg ggcaggtttt 100320
tatggatggt tctttttact acaagcaggt atgctacttt tcttactctt agctagaaaa 100380
gttaaagatg ataaggaatc aatactatac tcaggtgctt cgttaatatg tgcattaggg 100440
atgataataa atcttcttat attttcttaa aaataagtgt tgacacttct aaacttttgt 100500
attatactat aagtataaca agtacaggag atgattaata tgagtaaaga aacaattaga 100560
agacaatttt caaacgcaat tgagattatg gcaacaacta aggaatggtg gaatttccct 100620
aaaagcttta atacaaataa agagtttaaa attaaaactt ttaaaaatga cacacttgta 100680
tttgaagttc gagaaggtaa tagaaactta ggaagctttg tagttttcac atgtattgac 100740
tttgattatg ataaacttga aggaacttca acacagtata tgattaatta ctttgctaag 100800
aaattaacta aagatatgtt taactatcat aagttacaac tatagtagga ggtggaaaga 100860
tgagagagga attaaaacct tttaatagaa aacaagttaa tgttaaaggg tacttagatg 100920
atgttaagta ctcaaagcgt agaagacata aaggtaatca acatggatgt gtaaaaataa 100980
cagttactga cgtaaagatt aatggtatat ctattgacca tgttaatatt gaagttggaa 101040
tttcttttta tgaaaaacta aaagaattac aaggaaaaag aattcaattt gtaggtactg 101100
tctacaaata cgttaaacat gctagaggtc ataaaggtag aattaaagga ttttataaag 101160
aggattatag tgtaactttg gataagaagt tacaaaagga ggaaaaataa tgattaaaag 101220
aagaaaacat ttagaccata cagtacaacc tgagaaagga tggagaacag taccttttaa 101280
tggttactat gaagcccacc cttcaggttt aattagaaat aaagtaacaa gaaaactaat 101340
taaaggaaca cagacaagga aaaatcatcc taagtggact gctcatgaga ttgtatattt 101400
aattaaccct aagaaaacaa gttattcacg aggtgttgtt attgcacata cctttcctga 101460
aatgattagc caatcacgag gagaccttaa gaacggtcac gtatgtttta aagatggtga 101520
cagaagtaat tgtcatgtaa ataatatgtt tattggtaaa ggtaatgtta ataagaatat 101580
ctacaaatta aatgattcct atttgactag aaaagatatt gaagaggata tcaacaactt 101640
agttaatgag agactattct ctcagttaga gttacttatt aagaaaaatg aacctgaaag 101700
aattacacct agcaatcact ttattaaaag agataataat gtattcagta tcacggattt 101760
atctaaaaac tctttagtag aatttgaatt agaaatcaaa aatattaaat aaggtggcta 101820
tataaatgaa tgagtggtat gctttatgtt actatgataa agtaggtaaa aagaaaatac 101880
ctaggcaagt tagagcacac agagatattt cagtattaga agagctaaaa gaaagattag 101940
aagaaagaaa tcctagtaca gaatactcta taaaaacaac aaaagaattt gatgaggaga 102000
gatagggatg ttaacaccac agcaaaaaga ttcattaaaa aagcaacaaa agaaattaag 102060
taaaaagaag aaataactgt tgacaaatga gtgtacatag gttatactta agttaacaaa 102120
taaagaggag gtatgaccta tgttattcat aatttttttc ttagcagtat tctttgtatt 102180
aggatttatt aacggatgga actcagaaga ctaaaaaagg agtggttata gtgaagttag 102240
aagataaagt attagaaaga attgattctc ttggaggtaa gttaggtgat attagccaac 102300
atgcttggga agctttagta aagtatcaaa ttatatatgg tattatagac cttatagtag 102360
gtattatagt tatagcatta actgtatttt tatggaagtt atttattaac caacataaaa 102420
aggtaaatga tatagataga gatgatgatt atagtttact atttgaagat tgtgaagatt 102480
tatcaggtat aggtttgttt tatgtaatag ctacatcaat catatcacta tttgcattta 102540
tatacttagt atatggaata cctatggata ttataaaaat actgaaccct gaggtatttg 102600
cagtaaaaga tttaatcgaa caagctaaag gaggaaacta aaatgaaaca aagagatttt 102660
gaatttgagg aagattttgt attaacttac gagtgtgagg attgcaaaca ttttgaagat 102720
tggggtcatg atgaagagcc tgaagaatgt agtgaatgtg gtagtagtga cttaattaac 102780
aatacaagtc atgaagacac tgagtgtgac atgtgtaaag ggtacattga tatgtggcaa 102840
gatggatata gatacatggg agataataaa gcataccttg aaaaagaaga ttcaggttta 102900
atttgtgaag attgttatga gaaattagat atttaataag gaggaaatta aaatgaacaa 102960
agcagtagag caagcaagta gtgcattagg gcaaggtttt tcagctatgg tatggcacca 103020
ggtgttagta ggtttaggat ttattttact aggggtgtta ttatctttat tagtttgggt 103080
actagtaaaa aaattacagg taccatttaa ccatccaaca gcttttgtag tatactcaat 103140
tatgttagtt agtattgttg ctagttttat ttggggtggt ttacacgtaa ttaaccctga 103200
gtattatgct attttagaac ttaaagggtt tataaagtag gaggaattct atgactaaag 103260
aagagttaga gcaaagagta aaagaacttg aagcagagaa taaagaactt aaaaaacaaa 103320
tagaacgttt tgaagacgag ggaggaaaaa caaaagatga atagtagaca aaagaaaatt 103380
ctaacattaa caataaataa ttttttaatg ttagccttag atactgtagc actaattaga 103440
tataaaaaag gtaaaattaa acaagagaac tataatacag gacagattac aagaacaata 103500
gttacaacag ctaactcatt aggtattctt tacttagaag aacaagagcg taaagaagtt 103560
aaagatatta aaataggtac ttttgaaact ggagacctta aaagatttat gaatacaaat 103620
aaataaaaag tttaagaaac ctattgacat taggtttctt ttattatata ctaatattat 103680
aagaaataag gaggttaact tatgaaaggt attattatat tttacaaaga agagaccaaa 103740
gaggatttag gatattttct tgggtttata aactttaagc tagaaggatt atcttacaca 103800
actgaaggta ctttagtaga taatgatgta gtagttttaa aggataacca aattaatgag 103860
gataatttag aacagtttag tatgtcaaac aataatttag ttattggaat actaggtcat 103920
tcatctcttt cagtacgtat ctatgaaaaa ggtattagac aagaaattga aagagtagaa 103980
gaatatttag aggagttgag acaataatgt tagcaatatt tgcattaatt tttggtttac 104040
tatttatttt atctttatta ggtattttta tttattctat atttttacga aagaaaaaac 104100
aattaataga agaaagagaa tcatttggta tttataatag aacgaaagaa aaactgggtg 104160
atgtaacacg tttagggtat gaggaagatg tatataagtt aatccataac caatctaata 104220
agacaatcat agaggataaa aagagtaaag ttgtagatac aattaaaaag atgtatgaat 104280
tagaattaac atctgtagat gtttctaagg tagaaggatt atctccactc gatacagaac 104340
ctatgacaaa tatgaaatta ctttcatata agctagatag agaaggatta tatagtttga 104400
gtaaatttat ttaggagtga tacaatggaa tttatagata aaaataatgt gattaaagct 104460
tacgatatac caaatgttta tttaaaaggt tatgtattac aggcatgtga taaaaatgga 104520
gatacaacag cttatgatgg ttatgaccaa atacactata aaaaaggtag agtattaaca 104580
ttcccttttg ataaaccatt aagaaagata aatgtactat caggatatta caaactattt 104640
aaaaaggagg acataatatg atttattttg ttagtgattt acattttggt catgataata 104700
ttagagaatt tgaagcacct acaagaagtc actggaactc agtagaagag atggatgaag 104760
gtttaattga gttgtggaat aatacaatta caaataacga tattgtttat aatattggag 104820
acttcttttt caatatgaaa ccgtctaaag tagaagatat acttaataga ctaaattaca 104880
aagagatgat actgattgca ggtaaccatg accataagaa acttataaaa ctatatgaac 104940
gtaatggtat tacagtaaag tacgcagata tgattaaaaa ggatggtaaa agattttatc 105000
taagccatta ccctacgcta ataggtagaa aaaacatgtt taatattcat ggtcatatac 105060
attcacagtt aatggataca gagtatcaca ttaatgtagg ttatgatgta gagggtaaga 105120
ttgcctatag ttttgatgat attataagta gagcaggtga atataatgga gaaattcaaa 105180
ggtaaagatt tatataaaac tagaattaga aagcaaacaa ttaaaaattt agttataaaa 105240
acagagaagc tacataataa acatggaaag tatagaccta tcggtcatgt ctattattac 105300
ccgaaaacaa aagagtttac tttatccaaa cctgagcaga aaatatttat agagtacatg 105360
aaggcattag gttttagtgt taaacacaag agacgtaaga aaataattat agtatacaag 105420
aatgtgttag atgaatatct tagtatgtat caggaagcaa ttgaaagtac gtgttgacaa 105480
ttaaggtata ctatgttata gtatagaaaa ggaggttaac tgatgaagca ttttattttg 105540
attttaggaa ttgtaattct agttattgca ttaggtattg ttttacctgc atggatttta 105600
caattagtgt tatctgcatt tggtgttaaa gtaagtattt gggtatgtat cgggatattt 105660
atcttaatca gtgcagtagg aagtatgttt agtagaaatt aaaggaggaa ctataaatgg 105720
caaaatatga atcaaatatc aacggagaaa attatattgc aacaccatca caagctttaa 105780
gagaggcact agcagaatta attaaagaag aaaagaactt tgcagattac caaactaagg 105840
gtgaggaaca gtatgaatca cagttacaac taagacactt cgatgcaatg atttctcagt 105900
atgaagaagc tattcgagta ttagaggata gatatttatc tcagattttt attccaaaag 105960
ataataagga ggaaaagtaa ttatgaaagc agagtcaata gcacgatttt ttcaggataa 106020
ggtattacaa atagaagggt ataaggtaag attcactcaa gctagttcat catatatttt 106080
agatatagat actatggatg aatcagtatt gtttttagat actgtagttt tcactctatc 106140
aggcaagtac ttattagata cacatattac gattaataaa cctgaaacac taagctctaa 106200
ggaattatac acagagattg gtaataaact acaagagatt gtaggagacc aaacgaaaac 106260
agatatcgaa ttaactcgat actttaagga ggtaaaataa atgaaatcag atgctattat 106320
aaattcatta ttaaatatga aacatataaa tatacaaaaa cacaatataa aagtaacact 106380
tgagaaaggt agatataagg gtgtagggta tctaatagag tttgaaacct caatacaata 106440
cagaaataat tataaattac aatctccaat aattatatct tacgaaaatg aagagcctaa 106500
agaaatcatt actcaaatta aagataaagt attgaaaatt gtagaagagc agataaagac 106560
agatgattta tttattgaag caattgatga tattaataag gagacagctc ttagaaaact 106620
aaagccttat attaatgaag aatactactc agtgtttaaa tcatctattg ataagggagt 106680
acctgtagtt ttaccttctg aacttttaga tagatgcaca ggaaaaacat caacaatggc 106740
ttatttagct atagaatatg atttacctct tatagtatca aacacagtca tggttagagt 106800
gctattaaat gattatccga ctattaaagt tacatcgaaa aaaagagaag gttacaaaga 106860
ctcaatagtg ttaattgacg agcctgactc tgaaatacta aatctttact taggtatgcc 106920
tgagtgtgat attattggta ttacgaaaaa ataaataaat ttataaatac ctgttgacaa 106980
caggtatttt ttatagtata ctttagatat aaagaaaaag gagaggttaa catgaataac 107040
aaacaaattg aaagattaca caagaaagca aacgaggtag taagtaaatc agaagatatt 107100
gaagatttag gttatgtgca ggcacataaa attattaaag gatatcttga tttaccagtg 107160
tctgattttg aaaagagaga tgtaatgact gaattactat tagcgttaga taaagctaat 107220
aaatctatag attaataagg gggtagtaat atggtagata ttataatttt aattgtcggt 107280
ttaatattat ttttagctag cggatataaa ttagttttag gtaaatatta tgataacaca 107340
gatttaaaaa tgttatttac aatctttggt atcggtacta tactattact tgtaggattt 107400
atattataaa ggaggaaatt ataaatgaac tataaagaag tactagaagt tattaaaaag 107460
aataagccat gtaaggttag atttactgga agtattttag caattgttaa taaggaattt 107520
aacgcagata ctgataaagg tgtgttacaa attgatgtat caaatattaa taaaaatgac 107580
tacattaagt tacaacagta ttgtttagaa agagatgatt atactgtagc aggagctatt 107640
ttattttaag ggggagtaat tatgaattat agagatttta ttacggattg tattagcggg 107700
ggttataacg tccacattag tgttactgag aaaagagttc atattatttc agaaatgaca 107760
tcagcatctt atccgaagaa agaaattaat ttggatgaac tgcaagctta tgtttattat 107820
atgaataatt ttggaagtca gattacaacg gagggattat aaatggaatt agttattaat 107880
attatagcag tattaattgg tatgtacggt atttactttt atgttacaaa atttagtact 107940
ggtctatcag gtattttaat tgtactaggt atggctgtag gtctttactt ttacttagat 108000
tacttaaatg ttagagagaa tgttattcga ttagtatctg taatgtttgg tgctttctta 108060
tttagtatcg agatgattta taataagatt atgttcgaaa ttaaaaaatc taagtatgat 108120
aagactgtta gaacgtacag aggagaccaa taagaatttt actataaaga gtacttaaaa 108180
taggttaagt gctctatatg gtaccttaaa atggcttaga attgaaatta aggagatgaa 108240
aagttatgta tcctgatata ggtgagttag cttataaatt aaaaagtact agagaaagac 108300
tagaaggtat tatgatggag gaagtttggg aaatacatca tagagagaca ggaaaattag 108360
tttttaaagg tggatactta gaagtaaaag aaatattaag aaaaatgtat aaggagaatt 108420
taacattagt agatgtagac acaatgttaa atatcggtca agggtttttt gatgttgcta 108480
aaagtatatc agcagaaaat gtatttcaaa taaactataa aaaggagtta ccacgatgat 108540
taaagtattt tcagaaatgg atacaaaata taaaacgatt gtaccggaga aattccctaa 108600
tggagaaatt aattttaaat atgatgacct aaaatattta gtagaaggag aactatggtt 108660
tgatgttttc tttaaatggg aaactgatgc agacttaatg catttgtata tgtttactaa 108720
gtatctagaa caattaggta ttaaaaataa tgtttccttc ctggaaattg cgtatttacc 108780
ttatagtaga atggatagag tagaagaagg tcatagcaat atgtttagtc ttaagtatat 108840
tgcagaattt attaacaatc ttaattataa atctgtgttg atagcagaag ctcatagccc 108900
tgtcacagaa aatctaatta aaaattctgt ttctataggt gtcacactta aattattaga 108960
ccaatatatt gaaatgtctg aagaacctgt aacaattgta ctaccggata aaggagctta 109020
tgacaggtac ctatctgatg tggaagacat cttaagggat tccaatattg aaaattattc 109080
aattgtatat ggtgaaaaga aacgtgattt tgaaacaggt aaaattaaag gtattaaaat 109140
tgttaaggat aaaaatactt tatatgataa ctgtattata ctagatgatt taacaagtta 109200
tgggggtaca tttgtaggtt gtaaaaaagc ccttgacaat cttaaggtaa atagtgtatc 109260
attaatattg acccatgcag agaaagtatt taaaaacggt aaattactcg attcaggatt 109320
taaagatatt attgtaacag actcaatgtt acctgatagc cagtgggaaa aagctattgc 109380
taaacataga gcacaagaaa acggaacaga attacaaata aagagtatcg aaagatatct 109440
ataaaaggag aagaataaac tatgctaaat ccaacattaa tgtgtgactt ttataaatta 109500
agtcacagag aacaataccc tgaaggtaca gaaattgtat acagtacact tgtacctaga 109560
agtaataagt actatgaaca tagtgataat attgtagtat ttggtattca atcacttgtt 109620
aaaaaatatt ttattgatat gtttaataaa gaattcttta atagacctaa agaggaagtt 109680
attaatgaat ataaacgtac agttaaattc acattaggac aagaaaaccc tgacgctaaa 109740
catttagagc agttacatga cctaggttac ttacctattg atgtaagagc tttaaaggaa 109800
ggtacagtag ttcaccctaa tacacctgtt atgacaattg aaaatactca ctcagatttc 109860
ttttggctaa ctaactattt agaaactatt attagtactc aaacatggca agcaatgact 109920
agtgctacac tagcatatga tatgcgtaaa atgttagata agtatgcatt agaaacagta 109980
ggtaatattg aagcagtaga tttccaagga catgacttta gtatgcgtgg aatgagttca 110040
ttagaaacag ctcaattaag ctcagcagga catgcaatta gttttaaagg tagtgacact 110100
gtacctgtag tagacttttt agaatcttac tacaatgcag atgtagaaaa agaaatggtt 110160
gttgcttcca tccctgctac tgaacattcg gttatgtgtg caaatggtga ttacgagaca 110220
atggatgaat atgaaacata caaacgtatg ttaacagaaa tttatccaac aggagtattc 110280
tctattgtat ctgatacttg ggacttttgg ggtaatatga ctaaaacttt acctaggtta 110340
aaagatatta ttatggaacg tgacggtaaa gtagtaatca gacctgatag tggagaccct 110400
gttaagatta tttgtggtga ccctgatgca gatactgagt atgaacgtaa aggtgctgta 110460
gaagtacttt gggatacttt tggaggtact gaaactgaaa aaggatataa agtactagat 110520
gaacatgtag gattaatcta tggtgattct attaactatg agcgtgctca gcaaatttgt 110580
gagggattaa aagcaaaagg ttttgcaagt attaacgttg tattaggtgt aggtagtttc 110640
tcttatcaat ttaatactcg tgatactcat gggtttgcaa tcaaagcaac atatgctaag 110700
attaaaaatg aagagaaact tatctataag aatcctaaaa cagacagtgg taaacgttca 110760
cataaaggta gagtagctgt ttacaaagat ggttcatggg aagataacct aaatcttcac 110820
cagtggttaa ataaacagaa tttaaatcaa ttagaacgag tatttgaaga cggtaaacta 110880
tacagagacc agtcactaag tgaaattaga gaaagaatta aaaataatta ataaatattt 110940
aaactcccta ttgacaaagg gagtttttta ttatatagta taactatagt aaataaagga 111000
gtgaaagaga tgatttataa aatatcaaaa cataattatt atagtaggtt tgagtattct 111060
acttaccctc ctgatgaagg gtttgcgtat gtagattatg tagatgtgat tcttatcggt 111120
gtagataatc ctaagaaaaa aaaggttatt accttaaaag taaatgagtt caattcggat 111180
gactataaag taggtcataa gtacaatatt ataaaaatac tatggtttga aaaatgggaa 111240
tggttaaagc cataagtaaa aggagagaaa taaaatgatt atagataaat taaatggagt 111300
taaactagaa ataagcggtc atgtcgtatc atttagtgta agaaagtttg atacaattaa 111360
tggtgagaga caattaatag actaccatca tattaaaaga aatagacaaa agtactttag 111420
aactactgaa gaattttata atgaatataa agaaattaag cctgacaaaa atgaaataga 111480
tgaaatgttt gaatctctag gttacgtaga tactgagtta gatgatgtag taagacacct 111540
ggaaaaggtt actgaaatat taggagttag tgaacaatat ttaaatcagt tatcttataa 111600
agctatagaa gagtatgtag ataaagtagt tacacttgaa attaaagagt tgaaaggaga 111660
gaaatagcat gaataataac tgggaaaaag aaagggttaa ctattgggaa aacgaagact 111720
gtccgaggga atacttagaa aaagcattca ttgacctagt agaatatgtc gaaggagtta 111780
cagtatcatc taaagatgtt aagcagttaa gagaagataa acttagagaa gatattgggt 111840
tttatgagta cgtagctgat aaataaatta gtatctacct attgacttag gtagatatct 111900
attatataat agtatacaag gagatgaaaa tatgaaaaag ttaatagtat tacttacaat 111960
tactatttct ctattactag gaggttgctc tcctgataac catgagggta aagtagtagg 112020
ggtaggtgaa tacagagaac caactactta tataaaatca ggtagcgtta ctgtcccagt 112080
cattggtgaa atgaaatatt atgtagattt agagacagat aaaggagaag accgtgtata 112140
tcttaataaa gaggtctatc ataagtttga taaaggtgat ggtttctcta atgtaggtaa 112200
gaaagtgtac aagaatgatg aattaatata taaaggagac taagtagtat gacacaattt 112260
atacatgata agaaagatag ttataatagt acaaatcgta attttgatac tcaatattat 112320
aaaaatatac ctttacaaca aattgatagg ggctatggtc aagcaaaagc taggaggttt 112380
acaataaata atacgaacca aaatatatgg atacctatga catatttaag acctaacggt 112440
actcttaaaa ataatattga tatagattgg atatttgtta aagaaaaaaa tagtttaaag 112500
aaagcaggat tagaaataaa aatagaaatt acagaaggtg gattataatg tatatactag 112560
agagaacaat taaaggtttt gtaggtcaaa aagatgatat cttaccttat tacttcagaa 112620
gtaaaaggga aattgttcat ttcttaaaat taatggaatt ccgtaagaaa gaaacaaatt 112680
attgggttaa aaagaatggt gattttacta ttataataag agctaaaaaa ttattatata 112740
ttgaagaata tatacaaaaa ctaaaggagt gggaaaatga cttatgatgt gtttgtatta 112800
tacaaaagaa gagaacctat tgcacaaggt agtatggaac attgtttaga tgtctattat 112860
tgggaaagat tacatggata tagtaataaa gggtatgagc tattacctat agaatatgac 112920
caggaggaac aattatgaat agtacaaaat tagtagatta ttttacaagt aaacaaggta 112980
aatatctaat attacctgat gaaactaaag ttaggttatc taatgtagat ttaatgtctt 113040
acattatgag actcactttt acttataaca cagaagttgt gtctatagat attgataagt 113100
tatactcaga ttctatagaa atgcatatac cacaaggtct ttatatgaca actgttgtta 113160
aaattcctaa tacacagagt gttagttcag ttcttcataa ggtattagag gaatgggtaa 113220
gacaagtaca aaatgatggt atattcggat tcgtatggga ggaattttaa tgtatagatt 113280
tttattgttt agctattctg attattaccc ttgcggtggg atggatgatg tagagcttaa 113340
gtttaatggt ttttctgagt taataagtaa caaagatgat ttgtatttaa gtgaaaatat 113400
tgaaatatac gatactaagt atgacaatat actatatatt agtaacaaag aaacgatatt 113460
aagtgaattt agagactatt taggataatg gtaaaaataa ttaaaaaata aaggagaaat 113520
gtaaaatggc aagagaagct aaacaaacag taaatacatt attacaaaga tacagaacag 113580
cattaagagc aaagaaaatt atttttaact taacagatga ccaaattgaa gaaatggact 113640
tagaagtaac acttactaca aagtatagta atagtgtgac aaatcaggta attaaaggta 113700
ctgacaagga tgtttcaatg cttatcctga ttttaagtaa cgaagaattt aatgataagg 113760
ttattaatat tgaaattgaa gaaatcaata ttattttata aaaactttaa ctctattaag 113820
agaagggcaa ctagtattta attttaaatg ggaggaatta atatgataaa tagatataaa 113880
aaggtatggg atgaaataac ccaacaaatt gttaatgtag aaattattaa ctttaaaaat 113940
gaaacagtaa caatagaatc tacagatgat tcaggattat cagagataag aggttttgaa 114000
gaagtagagt ttatagatta ctatggataa gatgtttaaa gtatataatt tataaggagg 114060
aaacatatgg acttgtttgc aaaaataatt attatgtcta taggagttgt ccctttaatt 114120
acatttatgg tatgtttagc tataacagat tattataata gacattagga ctaataggag 114180
tatgttgact aataaggaag atatatagga gaggagttaa tcaagtaaaa ccaataaaat 114240
caattaaaac caagtaaagt aactaaacaa tacctagagc ctgggaaaac ttttacctct 114300
cccactcagc ctattactta ctaccgactt ccctaactat gtattctata gttataatat 114360
tcatttatta tacaatactt aaactatagt attgtaacct taatctatac tgaagcggta 114420
ttaatctatt gttattatat aataatctta tataatggtg gtataatcta ggttattaca 114480
ttagaatcat tctaatctag aattttaatc tttagaccct aggaaaagtg gtactaaaat 114540
atagaaccct ataggtatgg gattcttatt tttaaaatta ctaaaaagta ttaggttttc 114600
cctagggtaa agttttaatg tacctaaaat cgtaagtagc tccttatcat ttaggtctgt 114660
ttaattgaga atattagaag atatccgctt caattacaat taattgttga caactatgaa 114720
gcggtctgtt atacttagta tataaggaga tgtataatat gattgatatt tatttacaca 114780
gtagatatag taaagataag ttaaaattta tccttaaagc aataagggat ttttctccta 114840
gagaattaac ctacgatttt aggaatccaa aagcggatgt tcgtattgag gaactactag 114900
gagatgacat agatgtattt gaatctatag cattagatta ccctaataat attaatatcc 114960
ttgtgggaga tagtggatac tcgatagttt atcagaatga ttttcttaca attaatgaat 115020
tgagtatagc tataaaggag gtagtaagat gataggtcaa attatactat tagctattgt 115080
tagtatagtt acaataggtt gtgtaggatt atttttctat gagacgttca agagtattaa 115140
gtatgatgct aatgataaaa tctttatgat tactggaagt atattaatgt tagttattat 115200
cgttagtggt gcattagcta tacttggcat ttagagctca tttaagaagc ggttaagtag 115260
ttcatgataa attggtctag aaatatatga ccgcttctct atggaaggct gagagggttt 115320
agaattgaaa ggagagatat aatgtatgat gatattataa tgaaggttat ttgtttttca 115380
ttatttacaa tattttatat gaagttaata tatgaaataa ttgatactat ggtagagaaa 115440
gatatgaaga tattatgggt agtattcact agcttatttt tatttgctat ctacatatct 115500
atattaatag taacagcttt gtttagagtt gtttagaatt gaaaggagga gatataatga 115560
aagcaattat atattgtgct aaaagatata gtaagcatac actgaagcat atcttagagg 115620
aactagaagc ggagaataga aacttaacat atagtactga catctcagat atggaggaag 115680
tggatgttat tatacaacac actagtctat ctttctcaga gttaatggat tcttgtgata 115740
gagtaagtaa agggtctgac cgcttctatg tatttgtagg taatcactca gggtattata 115800
taaacgggga tttatatatt aacgaaataa ataagtttat tgtacctaga gaaactaatg 115860
ttatgatgta gaggaggaga tataatgatt catatatttg taaaagaaga ttataataaa 115920
gaaacattaa agactatact ttggcatatt gatactactg tagataggga attaacttat 115980
ggtattaata cagactatga taaggatata gtagttgaaa cagatgaccc aatagatgag 116040
gaagatgcac ttgagttatc aggtatgagc gggttcaaag gtgacttact tattcttgta 116100
gggacgggat actgtcaggc attccttaat ggtcacccta ctagtatacg tcactatgta 116160
gggaggatga tataatgatt aaaatattta tcgggaagcg ggattataaa cacactttaa 116220
aagtagtatt atggtttatt gataatgagt cctcaagaga gtttacctat agtgtagata 116280
atgctatggt tgatgcagat gtacatgtat atgtaactaa gttatttagt agtgagtata 116340
ttagagagca ctcaggagaa gtaccggagg atatatttgt acatatagaa gaaggtatag 116400
gtatatatgt agatggtgag gtaaggtctc ttgatgtact tgaagaatat atagagagga 116460
tgaaataaat gtttaatgtg tattatacag tttatcataa gcaaagtatg aagacgatta 116520
aggataagtt agatagggat agtttaatct atttcttata tgaaacttgg tataaagata 116580
taaataatgt atgtccttct aattataatc cggaatttgg tagtcttaat aaagatatag 116640
acataaatag gttaattgaa gcggttaatg aagaagggat actacttatt aaccgtgggt 116700
atgatataga gttataggat gttgacaaat tgtaagtagt gtggtatgat taagatagaa 116760
attttaggat aaaaccgtag gataaaaccg taggataaaa aggaggataa aataggatag 116820
gatgaacgat ataataaaaa caattgatat tgaatgtatg aaagctaaac ctatattcaa 116880
gatgtttgga gcaaattggg ttgagatggg tttaactaat aatacgtgcc cttctaagat 116940
atattatata tcagatactg gtatgatagc tgtaaaggat aaggacgttg ttaaaactct 117000
atttagtctt cataatacta aacaaaaaga tgattactat tgttggggct taaataaaag 117060
aacacttcta attcataggt tagtagctag ttactttcac catgtaccct atagtagtaa 117120
tttacaagta catcatttaa ataataattc taaggataat aggtctgata atttacattg 117180
gtgtagtcat gaagagcata tgttattaga gatagaagcg ggtattagag aacctattaa 117240
taactttaat attcatggta gaaaatttac acctgaacaa gttagagaaa tgcgtaagtt 117300
acattctgaa ggtcacagta ttggttctat atctagggag tttaatactt ctcatgggac 117360
agttagacaa gtagttaggt atttatcata taaggatatt caataagtag ctcccttgtt 117420
tttaggttag aataattagt aagtagctcc ctagtaattc actaagtagc tctcgatttt 117480
ttgatatagt tgtaagtagc tccctggtaa ttgactaagt agctccctgt cttttcccct 117540
agtttacccc aaccgcttca agcagaccgc aaaaagaatc cccaggaatt atattcccag 117600
ggatttctat aattttttta tagaatattc ataacattat attcaaattg acctacttca 117660
tgttgtgatt taattaaatt tttaactaat ccgttttgtg ttttgtacga tttaattagt 117720
ttttcatttt ctataattaa attattaaat tctttttcag ttgtttcttc ttctatataa 117780
aatacacttt catatatttc ataatatttt ttatcttttt cagactctaa atcatctgat 117840
atttgataat ttttgaatac aatttctgta gattctaatt cattttgaat taattccgtt 117900
tttgcatatt gtaacacatc ttcattttcc cacattggta tataatttat tttcatttaa 117960
atcaaatcct tttcttataa tttttttata taatttctgt aaggtgcttt gtttcttccg 118020
tttgattacc ttacaaatac tattatagca gattgaaata taaaatcaat agttttttac 118080
aaattaaatg agaagtttta cactttatga caatttaaaa aagtgtaaaa ttggtgcttg 118140
acaaatcggc ttttatcctt tatcataata attggagggg tctgtctgtc ttatatatag 118200
gttaaggtcg atcgataggt tgtgcacaat taaattaatc tactatacta tttatttttt 118260
gcttaatttc cagtttcttc cattagaaac aaaaaaaggg ctttaaaagt tttttaaaaa 118320
agttgtctaa acctattgac ttattaatca tatggtagta atattaaggt acagcaaggg 118380
aacagcaaca agatattaga attatataaa aaaattattt aattggagtt ggtttaaatg 118440
gatgtaaaag aaattgcaga cactataatg gagttgtggc aaatggacgg atacagatgt 118500
acagaaccgc cattatatga aagcacatta aaccacacac gcacatatac ggctttaatc 118560
gtaagcatta agggaaacta tgacactgtt caaatgttcc gtaaaacgcc tataatgagc 118620
atgagagggc aagcgcaacc ggctagcatg ttagtaaatg taattgatga cgtgattata 118680
atcgtatatg aaaatacggt ttacggggta cagaataaag aaataaaatt tattgaagaa 118740
atttaaaaat aggggttgca atacccctta agatgtagta atataataga tgtaagggat 118800
agcaacacac cttaaaaaac tttttaaaaa agttaaagaa aagtgttgac accttacaag 118860
atacatgtta atattagtat agaagttaag acaagccaca tagcaaataa cgaaattaaa 118920
taaaaaaatt atagaatagg atttgattat tatgacaaac aaaaattact tatacgaaga 118980
aactcacaca gtacaagggc aagacattac ggctttcaga attccaaatg acacaaacgg 119040
caacccacgt tatgtagtgc atttcatgga tttagacatt aaactagcag actatgacaa 119100
catcaataag ctatacggat ttaaaaaata tactgctaaa tggtttggcg gtggtgtagt 119160
attccaaagc tataatattg aagatacatt aaattacgca ctatctaatg ttaaagaaat 119220
agaagcggtt aagaattaaa accgcttctg aattaaataa aaaaaattat ataaaaagga 119280
tatgatatta tgaaatttaa aatagaaaaa aataacagtg atataaaaac tttatggaat 119340
ttagctaaaa atggatatat gagttatcaa actgtacaca atatatttaa aaatgaatca 119400
gatgaattta ttatatttaa cagtaaacaa acttataata aatttatgga attaagatat 119460
aatagaagtg caattcaata gtataaaaaa gttatataat tccctaggat taaattccta 119520
gggattttta tttgttttaa tttatataaa aaaattattt aataaataaa ttagtgtaaa 119580
attgactgtt gacaaggttg tattttttat ggtataatga agtgaagacc ttttttagta 119640
taaaaaaatt attatataaa aaatttatat taaatggttt taaaaccgct ctttctcccc 119700
accttgtcat atttatagtg gaagggttag gcgggttacc actgttttac tttctatata 119760
tagtatacta tgaataatgg taattgtcaa cacctttcag aaactttttt tactttcttt 119820
tattattata taaaaaaatt atacatattt tagggctcca cttccattat ataataattc 119880
ggtcttaatg tcaatacttt tattcaaaaa agttttttaa attaatttca acaaatctat 119940
tgacttatgt ttttttctat agtaatatat aggtatacca acaagggagg caatacaaat 120000
gctaaaattt aaatggaaaa acaaaacaat caaatcaact caaaaaacgg ataacattat 120060
tttacttctt ataggtggtt tagttgcaac agtcacgcct aaacttgtaa actggttttt 120120
actactacaa gataatataa atattttttt aagataacta ttgacaactt agaaacaacg 120180
tgttaatatt aagatacaag gtaagggaag cggttgaccg cttccgacct aaataaaaaa 120240
agtttaaaaa aactattgac agtcacttga aaccatgata ttattaagat aacaaaaaac 120300
aaacagaaaa ggaattgatt ataatgaaat ttatcaaaac tatcgaaaac ttattagaaa 120360
aagcagaaaa caaagggcaa gcaattttaa acggtcgtta ctttgacggg tatagcaaag 120420
gtgagcttga ggaaaaatat gcaattgaaa ttgatggcaa caaattgatt atgcgtcact 120480
ggggtacaca aacaattgag attgacttaa gcataaatga gattgtttca tattacggtg 120540
aaagcaattc agaccgtgac agtttaaaca cacttgtata ttgcttagga attgcgccaa 120600
actttagata cttaccaagc aaaaacttat tcatttacga aaattaatta aataaagggc 120660
ttgacttcca agccctacca tgttattatt aaattgtaag gtaatcaagc acaacgacaa 120720
aataaactga aaaggaattg atgaaaatga caaatactaa ggattttaat aaaaatttct 120780
taagattatt aaaagttaaa aatgtaaatg ataaaagggt gcaaggtttc ataaacaagc 120840
atgatattaa acttaaggat aaagaagaaa gttcacaagg atatgttaac gtattataca 120900
aaggttatga ttttgtaata tcaaaagact atgcgggtca aacggcgtta tatgttaaca 120960
tgcgtaattt aagggttgac tacaaacatt ttaagcattt agattttaat aatattgttc 121020
aagcattaga aagaaaaaat aacaatcgta ttgagtgcaa ggaaacaaaa acacaacaat 121080
ataaagaatt taaacaccgt caaaaaacag aaaaagaaat gttaacatac tatgaaaagg 121140
atatcgaaaa actaaaagaa gaattggaac gcaaacaaaa attctataat gacataacaa 121200
agaaaattga aaattatgat aaaaaaatat ctagactaaa aaaatcaaaa taaggcttga 121260
cactctcaag ccttaatggt atacttagta taacaaatca aagagaaaag gaattgatga 121320
aaatgttcaa attacaaaat aaagtggaaa ttatcgtacc taaagaggat aacaacggtg 121380
ttgagattgc agacaaacgt attaaagaat atgtaaacag tattacaatg gaagcgggcg 121440
gttgcactat tacagaaatt aagggacaat ggtattcaga agatgaaaag cgtatcatgg 121500
aagataacaa cttaaatctt gaatggtact acattccaga ccgtgcaaaa ttcatgacag 121560
ttgaattaaa aggcattgta agacgtttaa ttgaggttta cggacaagag gctatcagta 121620
tcaaagttaa tggcacattg tacattgtag accaatcaga cattgaagaa ttacacacaa 121680
cattattaaa tatcatgaaa taaaaaattt atataaaccg cttcggatta aattcttgaa 121740
gcggtatttt tgtgtaaaat ttatgcttga caaatgtatt aaaaaatgag ataatagagt 121800
gacgactttt tttagtataa aaataatatt atataaaaaa gttatagagt ttttagggct 121860
ccaagtccat tatatcaatt ttgctactag ttgtcaatac tttctttttt tatataataa 121920
tttaattatc ttaaagatac cgtccacctc cattatctca aattttgccc ctaaagtcaa 121980
gaactttctt tcaaataatt tatttaaaaa agtttacaaa aagggttgac ttattttgta 122040
ctatggtgta atatataaag tgtagtaagg aagcggagga aataacctaa aaaaagaatt 122100
taaaaaactt ttaaaaaggt gttgacaaac ttccaaatac atgataatat taagatagtt 122160
agaaaaacaa aaaaacgaaa aggaattgat aattatgaac agattagaaa tagtaaaaga 122220
tacggcaatg gaatatatcc ttatgatgga taatagcgtt atggacggcg ttatgacaca 122280
agaggaatac aacgaagcgg ttagctttga aaaggtgtat gactacactc tatcagaagc 122340
aaatcaagaa tgtaaattct taggtggtaa ggttttaact ttcctagtac atgaagcaat 122400
cgaagaatac gcataaaaaa acttaataaa aggggttgac attcaacccc taccatgtta 122460
atattaatat ataccaaatg agagggattg ataattatga gatacgaaat tgtaacgcta 122520
gttaatcaag aattgtttat gtatgcaaca ttcaacaagc aggaagcaga agcaaaatat 122580
agtgaatggt gcgacctgta cggtcaagaa aatgtaagca tggaaaaaaa ttaaaataag 122640
cggttgacaa actaaccgct tcatgataat attaaactat actaaagaaa aggaaatgat 122700
tacaatgaca aaaacaatca aacaattaga aagccaatta gagagtctag aaagaaaatc 122760
agatgaggaa ttagcaaacg gatactatga cagatttgaa agaacttgtg cacagattag 122820
agaattagac ctacaaatcg aattaaaaaa gaactcagaa actgtttaaa aaaatctaaa 122880
taaggggttg acacttaacc ccttacatgt taatattaag atagttaaaa aatacaaata 122940
agaaaaggaa ttgatacaaa tgaaattaat caatagagat aatgaaatcg taattagcat 123000
agcaacactt gagagcgtaa aacaagccct aatttgggag tacatcgacc acttagataa 123060
taacatccta gacagtaaaa tttacgacca agaagcggtt gtggtgactt ctgacactct 123120
acagtcaatc aaatttgcgg acactatgga agaactagaa gaatatgtaa acgacatcgg 123180
ttggaaatta atttaaaaaa ggtattgaca ccctagcata tagatggtaa tataagagta 123240
tagaaaaaat aaaaaaagaa aaggatttga ttattatgac aaatacaata caagcatttt 123300
tacaaggaca agaagcaagc acagttaagg acgtagcaac tcatggagta caaagcggag 123360
caattggcaa attaatctac acatcagaca tagtaaactt ctttgataga tacgagcagg 123420
acattgaagc cgtcatcact gaatacattg aagaggttac gggacaacaa tattatgact 123480
tattgaacta tgagcttatg agagacctcg agaattatgc aaatgtagaa tttgaagacg 123540
aagacgaata taataacatt caatttgacc tagcagaaaa cattgcttct gatgaggttg 123600
aaggatttga agacatggac gaagcagacc aggcggaagc aatctatgag gctatggatg 123660
atgttgaatt agaactacaa gaaacggaca aggttcaata tgttaatcta gcggttgaga 123720
ttgtagcgca aagaatggca ctataggaag cacacagaca cacacagaga agcttaaccg 123780
cttctctaat acaattaatc aggagatgtt gaagatgaaa attaaccaat taaacaatgc 123840
taaaaaacta tacgaaacat tatttgctat cgagtttgat agtactatcg aggaagattg 123900
gacaatagat aatgactctc tagaagctaa actattcttg gagttatcag atgagggcaa 123960
aaaggtttat gcaatgagtc acgctaagca atgggcaaat attgttatgg atatggaaga 124020
agaggaatat agaagctatt acggaaatga tttagattat attttagagg agatgtaaaa 124080
catgaataca agaagggtaa acaaagcgtt aaacgaagcg gttcgattat tagatgagca 124140
aatagcagac actcaaaaga ctatgcagga gttgaataaa caactcgaga agcaaataaa 124200
ggctaagcaa gagctaatga tattagttga tgttatgact ggtgatgatg agtaatgagc 124260
attagagagg ttcataatgt cgttaagagt gcaaagagca aactcctgca ggaacataat 124320
aatattaata atgtaatcat agatgactac atcacagaag agctacacag acgcacacag 124380
ggaagcggaa ccgtacagat gaacaataac accgcttcat atagtaatgt ctcatatggt 124440
agcttagaag agcttagaga ggcttatgac ctctcttctc tatctactgg tgagattaga 124500
gaactgattg aaacatttgt ttaaaaaagt tttatcaaaa cactttacaa ctatttaatt 124560
tgtatgctat aatgaactta acaaattaaa agaaaaggaa atgatgaaca tgaaagaaca 124620
aatcaaacaa tttgaaagag aacttgaaat ggcagtgaat aacttattcg tattacatga 124680
ttgtggagta tcacaagcag agcttgaaga acaaaaccaa aaggttatct acttaaaagc 124740
tatcgttgag aacatgaaag cttatgcaga agttagagta gagccaaaga gtgaagaaca 124800
atttttcaaa gaacttgaag aagaacttgc agaagaagaa agaattttaa aaggaattta 124860
agaggagggc aaacgccctt ctttattttt atcctattat ataatttttt tatattatac 124920
gggggcaggg gtaaaatgcc actcaatggg ggtgggtcta tataccccta cggtctaccc 124980
aggtacttat tttttgggga aaattatgaa aataaatatt taaaagtcaa cacataaaat 125040
acagaaagta agtcaacatc ccttataata agtcaacatt ataaccttac tcgataagtc 125100
aacaatttat agtacaaata taaagcctct aaatataaag tcaacatatc taaaataaga 125160
agagaggtat atcctctcct ctcttaacta gataagtacg attctattat ttagttcctg 125220
ttctactcta ttcaagtgtt cccaaacctc aatccagttt actcttgaat catcataata 125280
aaggtggaaa tcttgagggt tttctaaata tgcttctagt tcatcatagt atagaacatc 125340
aaaagctgtg tcatcaagac ctatttgaat ctttagtata tctttatatc ctaattgttt 125400
attaccgcaa taagctgtat cttctaaccg tttctctagt ttattaaata gtgtttgtat 125460
accttgtagt tcattcataa tgtatgacct cctaattgat tatatactta gtataaagga 125520
taggtgttag aatgtcaacc tttatatata aaaaaaagag aaagaatatt attcttcctc 125580
taaggtatta ctaataactt ctaattcatg aatagtaatc atatccattc tatcgaatcc 125640
tctcgggtct cctttaatga actcttgttc tcctctatgg gttatacttt ctttgtatcc 125700
ttcttcttta atacgtttaa ttaagttctc cttatttgtg tatatctcat cttctctgaa 125760
atggaaatta tcttcatagg gttcacaatt atcatgttct acttgatata gtttcattca 125820
tttatcctcc ttttcataag tccactcacc gtattctgcg ttaaaatgag ctgtgtctgt 125880
tccctcatct tcatattcta cactatacca tgcatcttct tctgtttctg catctatata 125940
tcttacttct tctgtagtaa tagtacgttt taccttaaat ctctccatat gtttttcctc 126000
tcccctacct tcatagatat tacctataac acataattct aaggtatttg tatatgattt 126060
taaatagaaa tcactaagca aagtaatctt gttaccttca taattttcta taaagaaaaa 126120
ccccttacct tttttaacga tacctgagtt tatatagtta ccactaatat cttgtatttc 126180
tacaatatct ccctcaaata tttctacact atttctatca ctaagacctg tgaattgcat 126240
aatttcaagg ttttctccta aataaccatc acaagcaaat agatgtgaat atactgtgta 126300
atctgcaaag tcaaacctag caatatcaaa cattctttgt gattcttcat cccacgctct 126360
aaatttaatc atctacttta ctctccttta tattctcttc taatatttgt tttaatgttt 126420
gacaatcttt ttggtctagg gtgtcccaac tctctagatt ctgtaattga tagtagaatt 126480
catttacaat ttcatcaaat gcttctgctt tttgatagac ttcttgtagc tcttctaatt 126540
ctttttcatt atcaatacac cagtagttct cgttgtcagt tataatatct tgaattttat 126600
ttttatattc ataagccatt atttatccct cctatcttct atcctttgtt ttatctcttc 126660
tctattgcgg tgatgttctt tactcatttc tttacgttcc ttatttgtta atctgattct 126720
ataaataaga tagttaatat ataatgttcc ggctgaccat agtagtagga atgatattag 126780
gtaagtccat gagacactta tttctatcat tgtgagccct ccttatattc tttataactt 126840
ttaataacaa tcttacatat acctctatta acagctaaaa ataacataaa tgataataga 126900
gttataactg ctctaatgtc tccagtaaag ggtaataatt taaatagtaa aacactttct 126960
aaaacacttg tagctgtaat aattgtaaga tataagatag atagtaaata atcctttaat 127020
tttagtttaa cgaaaggttt tttattatct tgagttcttg ttataccata tagaattata 127080
aaccatgcaa caggtatgag ctgagttata aagtcattgt ttatgcctaa tacatataaa 127140
ccataaatga taccggcagg aataccaata atgaatgcta agaatacaga gaatataatt 127200
agcattaaag gaagagctac aagtaatcct agaccttgta ttgaatactc taatgtattc 127260
tttcctaagg ctttaaagaa tgttttattc atataattct tcctcttctt ctatagaatt 127320
actttccgta atagttactt ctagcatatt attgtaatac tcgttctttt ggttaatatt 127380
atagttatca ttatattcat tgaagtctac ataaatgtat tcatttgttc catcttcata 127440
aataatatct atagctgtaa tatctgagta cgctgtaatc atttcataag catttgtatt 127500
atcagggtaa gcaaaaccga cttgaggtat ttctttaggc ttattaatga gaataccaaa 127560
gtaagtacaa tgacgtgttc tattcatatg gggagtccct ttatacgtac catagtaatc 127620
tattccttct gtaatacctt ctatatggaa cctgtttaca tctttaggtt ctaatcttac 127680
tacatcacaa ttttctaata ctaagtctat atattttata ttcattttaa ctctcctttt 127740
atattaataa ttctttccat tctttatcaa tctttttaag ttctttttta ttatagtctc 127800
catctttagt tgtcacagca ttccattgaa acttttgtaa taaactaaag ttgtttataa 127860
tccatatatt acttttacta taatacatgt tatcttcaaa tcttatatct ttttctataa 127920
agtatttata tattttatat cttctttcat ctgcacctga tattttaata atttcattag 127980
tatttaattg agtggataac tggaagataa tatcttttac ttttaatagg tctttaacat 128040
tacctcttcc tacatggtca ttatagtaat cgtacttagc ttttttcttt tgttttctat 128100
cattgactac gataaatatg ttataaataa tataagcttt aaaatgggta taagaagtag 128160
gtgcctctga gtcatcacat tcttttctta ggtctgtaca ttgtatcttt aacgtaatat 128220
tatttgatat gttaattacg gtagaaccat cgtgtttttt attaagattt atcttatcca 128280
tcttataatt acctacttat tatagataca gtgtactcga acatcttcca ttactttacc 128340
taatagattc tgacctttcc agttactctc atctaatatt ttagggtcac ttgctttaag 128400
acctactccc catattttat cataaggtga tgcctctacg aaatctttac atacatctgt 128460
atctaatatt ttttgtttta agtgtgtagt cataaattta tctttaacca cttctaccat 128520
aatgtcatat cttaccttat tccattgctc ttcattaaaa ttacgaactt tacgacctag 128580
acttttagca tggttcggat ttttagcatt taatatttcc cctgctattt gccagtcttt 128640
aaaatattgc gctttgcgcc acataaaagc ttgttctgag ttattaaatg ttcttccttt 128700
atgtttaaat gctattgggt aaaagttaga ataaatatct tccttacccc aaaacataat 128760
gtatctgctt gtttctctca taatatctcc cctttaattc cataatgatg gtaacacaat 128820
tttgaaatta tctaatattt tattttgtac ttgttcaagc tcatcatact tatccatatc 128880
aaaatcatcc atttcttcat gataatattg tattaagctt aaaatatgtt ttatcatatc 128940
tatttgtgtt ctctcttcac catctacatc tacaaaagta ttccattcca tatctataca 129000
agaacgttca ctactttcta taaaggcatt taaatcggca tataattgaa caaaaaagga 129060
catatcatag ttccaatact taggttcatt tcttcctaat tttttattca tttttttata 129120
ctttctattt ctctttaaac caaaaacttc tttttcaaaa tcatttaatt ttaaaccttt 129180
aaaatatttt ttcttcatat ctaatcctcc aatttaataa gtggtaaatc tatatctcta 129240
aatacagaac ctacgtcaca tagcagtata tcattatgtt cttctacttc accactacta 129300
gtaggtgtat gaccacatac atatataaat ccatcttttc taggttggaa gtctctagac 129360
catattaact ggtctactgt ttgctcttct ataggtttcc aactaactcc tcctgaatgg 129420
gaaaatatat acttaccttc tttataatac cttctacaat taaccataaa tattttaaat 129480
tttctataat cttcagattc tttaagtttc tttagttcac ttttaataaa atcataatga 129540
tttcttaaat tatcttctac acttttatat tttaaagtta cagtactaac accgtaagag 129600
ttaagtgttt ctatacaata ccttgataac cattcaatat catagatact taaccggtct 129660
acgttttcca taatactata aaactcatca tcgtgatttc ctaataaagc tactacatta 129720
tcatcatttg ataataaatc aaacatgtag ttaacaacgt cttttgacct tttacctcta 129780
tctacataat cacctagaaa tactactgtt tcttcaggtt ttctctcttc atttatctta 129840
tccataattt tcagtaattt attgtattct ccgtgaatat ccggaaccac gtatatagcc 129900
atttaatctc ctccttattg tatataacta tcttaccata cttatttata aaagtcaata 129960
aaaaaacacc tattaatgaa aataggtgtc cgacagagct cccgtactta gattacggtt 130020
aataatattt tacgacaatt atatgagacc ctctgtcgtt gaaacgctcg tcactgcgtt 130080
agatacggaa tggagggata ctaccatccg gagtctacgg tcagatacaa agcctctgcc 130140
gggcaacata cggtatctct cgtacattag gttgactaga cctttagaga ttttcactcc 130200
ttctcttata accagtaact taagagaaat aggttttact tagtagatat gaaacaataa 130260
atccacatat aatattaaac catagtcaag tgattgcaca tatgtctaat acctataagt 130320
tttttgctag cctggtatat ggactctgta ggattcgaac ctacagtaaa accgttatga 130380
gcggttggct ttacctttaa gctaagagtc ctagaaatat cctgagagag gactcgaacc 130440
tcaacgacta ggtagctaca actagccaat gccattactc aggattgcta gtaacgctaa 130500
atagagtcat aacgttaccg tagacctttt ctacacttgg tagataggta aaatataatg 130560
atttcaaagt acctatatag tcaggctctt actctcatta taaggttaaa aaggttaact 130620
gtgtttagca ttatataaga ggctttagtt aactactata ctaatagtat atcataaata 130680
gtacttagtg tcaagataat ttatcaattg aatccataat tttggatgta cttcttatat 130740
ccgcttcttt actgtgttta agaagatatt ttaatttcat tagaaaataa ttcttttcct 130800
tttctatagt atctttcttg ttactatatt ctgaatacat cataaattct ataaatatac 130860
tatttctgtc agatgaaaac atatctatag aaaatggaca atcaaaactt atgtcatctt 130920
tattaatact aaaacattca gtaacattta agtcatttat ttcatatacc tcgaaatatc 130980
catcaactct tttaagttct atagcactat tatatctata ataacgttgt tcctctatta 131040
acttatcttt tgttagataa ggatattcat ttataaatat aggattactt gttccatagt 131100
tatttttaat atattcagca tcttctaagg aatcagtata acctaaaact tcgtaacttg 131160
ttgtatacac agtatcttct tcccacaagt catagtccat ttcctctatt tcttcctcta 131220
atatataaat ttttttcata tattactccc aaacaccaat aagattttta agtttagcta 131280
taacctcttc ttctgtttga taagaaaata ctcctgtaat gtgttcatag ttacctacaa 131340
tttcataatc ctgcgtacca tgtctgtcta ctagatacga gttacccata acatttaaac 131400
tatcctctga ataactgaaa tttatattat agtctactaa aaaattaata acttttttca 131460
tttacataac ctctcctatc ggatattgtc ctaacattct tgttccattt tcattataaa 131520
aagtatattc tactacaata atattcatca tatctacata tatagcttct atataaggtg 131580
taatattttc ttcttcttgt atatgcttac ctataatatc atataataat tcagagtgta 131640
ttcttttatc tctcattgta gacctccgta agaaatgcta cagttttatc ttttaaagat 131700
ttttctacta gttccatagc atctttatag tgttttatat tcgattcatt agacttcagt 131760
ttatctttta cctcttgaat taagggttca actttagtaa ctaaatcttt tttattttcc 131820
atacttacat tacttctctt gttatctaat acttcttttg gcatatactt aacttttgca 131880
aagtctgtat agctaacatt taagttatct aaatcatcta ataaatcatt atagtattct 131940
aagtgattat agaacgtgta aaacttaaca aggtctttac ctgttagttc ttctcttttc 132000
aatatagaat taatattacc tataacggaa taagctatag ttttgaaatt agctctcaca 132060
taagtcagaa atataaaatc atcatagaat aaatctagaa cagttttatt gaatctagta 132120
ttctcagctt gttctaattg agcacataga ttaagaacat tgtcgaaacc actttttagt 132180
attaaagaaa taaacctctc taccgcatag tacctagata cttctgtatg tttgcttgct 132240
ttttcactat ttctaaaaat agtatctgat aaaggttgaa ctactaggct catataatct 132300
ttatctgaat actcatccga agttccttga taggtacttc caaattctat tgttgataat 132360
aagaaacttt tttctaaatt cattataaca tcctcctttt acttgttatt ataatattaa 132420
cacatatgtt tattaatgtc aaacattaaa tatcttctgt tgtatcaact tcatcttgct 132480
tatacttaaa gtactcataa actttaaata atataactcc taaagttatt aaccctaaaa 132540
tatatttcat aacaatcctc cttaataacc gtgtttagtt acccatcctg ctaaagcatc 132600
catagccata tcatattctt cttcattttt aattcttata atttcctcta tttcttcttt 132660
tgcttgttca gaactaataa aatcaatatc ggtagcctct aggttagtta attctaaatt 132720
ttctctaata aaattctttt gacctggtgt tatagaatta actcgtacat tttcgtgatt 132780
taaaaattga tagaagtcca tattattcac cctcttttaa acagtctgcc atatctttta 132840
aagtattaag tacatatttc aaatctctat agtggatgtc agaagaataa ataatggaat 132900
aaggtgccat atcactgtaa tgtgcacaat caaaccctaa taccctgtaa tcacctccat 132960
gttcatcata cgtaatacct ccatgagaaa agctttctat agcattaaac ttctcttcag 133020
ttatatcagt aggtacatta atatacccat tcaaatgccc catgtcaggg tgacgcttaa 133080
ccgttaattc tataccttta taatctatat ttaaagttaa atcctctcct aatatattat 133140
cctctttggc tatagttttc ataacatgtt ccggtgcttt ttcaaacata atgtatacct 133200
ccttttattt ataattctac tatacactat tttttatgtt ttgtcaactt ttatttctta 133260
ctccaccttc aacataaatt cctaaagact taactaaatt tttgatggca gtagcactta 133320
aatcatactt agaacctata cttttatatc cctcaccctg caggtatctt ctttttacat 133380
cctcagtatc taccttatta taagttatat taaacgttaa ttgattcttt atttttcttt 133440
cgttaactaa taaaaaaggt aattttgttt ttaaatcact tataagtgat tttatattag 133500
ttgaaaagta attaatctct ataagaacta tattattatt tttacaaaat tcttttttta 133560
ttttatcatt ttcaataata gattggtggt caaatctacc tgagtaggta tcttctatat 133620
gctgtctccc ttgcacttca atacaatatt caatgtcatt atacatgaaa taaaaatcaa 133680
atcttaaatt aaatccttta ttacttttta gattcataaa tgttttttca gttatatagt 133740
ctacactatt atcaattaat atagtttcaa ctgctttttc ccctttagac cttctatcgg 133800
agcacatacg acatcctaaa ccataattat ataaatcagt tagcttcatc ttttttgtat 133860
cagaacatct aggacaggtt accttaacaa ccttattaga ttgtaagggt aaatctttta 133920
cctcttccca attactatgg aatagctcct tcatattttc attatcagac agtcttttct 133980
cgaagaggtt tttaaccctt acttctttta aattcttacc acatatattt atagttcttt 134040
tattaaaatc gttataaagt tctaaataat gtgttttatt aaaataatac tttattacat 134100
taatattgta tacttcatta ttataaacta ttttaatatt tttccctggt aattcattcc 134160
attttaagtt accattatca tatattgatg ataggtctac agaatttatt tctctacctc 134220
tgtcacagta gtatacacct tctatattat atctttttat agtcataccg tacactctcc 134280
tgttatctta aataatcttt aagctgttct tctttataga atcttctatt agtaggtgtt 134340
ctatacgcca ctaatatacc ctctctatcc catctttgta atgttttaac agtaactcct 134400
aataacttag ctacttcttt tggtttaagt cccatatttg attacctcct gtttttttat 134460
ctatacataa tataacacaa ataaacacat tttaacacct ttttttttaa aataaaaaaa 134520
taggcatgaa taaacatgcc taataaagta ttacttttgg tagtatttcc atttgaagta 134580
accatttttc tgtgagaact catagtgaaa accatcgtag tcaaattcaa tattatagtc 134640
tccatcttga agcggttttg aatttagtac aggactatta ctctttgcca attctgctag 134700
aaactcatga tttacttttt ccataaggtt tattcctcct agttattctt acagtattaa 134760
tatatcacag gtctttttct aggtcggttt taaacttctc ttcatatgag ctagcataag 134820
ttacttcata tcctattatc ttagtataat ctatacatag taatttgtaa ttggatttta 134880
ttttaatgtc ttctgcttgt tctattttgt tgataatttc atctagttca ttcgaagagt 134940
aatgctcatt atctaccttt attgtttttc cttgggtata gatatcaatt tcttgtatca 135000
tcatttcatc cttttgatta ttcattattt gattataagt ttctaaatca tcaatattat 135060
ctgtatctga accttttact aaccattctc ctctcttttt aaggaggtca tcaaacttct 135120
catgctcttt aattatcttc tctacttcac ttggtattag aacagctcta gcgtaattta 135180
tatgccacat agacatatta tcaataagat aattaaccat tcttataagt tccttctcat 135240
ttgccatata ccaacctcct tatatctaat actaatataa gagaaaagca gacttattaa 135300
aagtctgctt ctgtacctaa ttctaatctt ctatttttca tatgaggaat cgtttttcta 135360
tctcctgtta atagagataa ttctctagct ttttctttag ataatgttaa tagtccatta 135420
taattatcta ctttactatt atattgtctg actaagtact ctagttcatc ttctatacct 135480
gatagttctc ctgatttaac tccaagtaac tttctataca tatcataatc ttcagaaaga 135540
ctttctactt tatttttaga tacagaatca taaactgctt gtaaattacc ttcttcaata 135600
agtttaaagt tatgttcacc tatgattaat tcttcctcat aagaatcaag tgtcactaat 135660
ccacttgtat tacctgtaaa gtcaccttta taatctacaa caataccttc agttactttg 135720
tcacctaatt caatagtccc atcttcattt tctttaaatt tatgagcatc atatacttct 135780
actttgtcac ctaatctcaa atcttgagtt aagttatgtt taccaataat tctatccatt 135840
actcaatctc tcctttatta atagggtctt gtgttaagaa catttctaga ttttcttttg 135900
taataggcaa ccaaaaatat ttactttccg gaattgtaac tgtatagaaa tcctcatcat 135960
tgttaacttt aatattaaca tctgtaaact catcctgcat taaccaatga gttacagtta 136020
agttatatga accatcacta acataaccta aatcaatatc atgtctaaaa gctaaatctt 136080
ctaagtattc taataaatca ttcttctcac tttgttcttc ttctgtatta tttttgattg 136140
gattaattaa ctctgtacaa acgatatcat acaactcacc atctgtaact tcataattct 136200
tttctattaa tacatcttgt attttattga ttgaatttgt aactactgct ccatattctt 136260
cttctgtaaa attacattta tctaaatcaa catctgtaat taattctgca atccatttat 136320
ttaaaattga taccgccatt gttctagaaa taatactatc atataccata tttatttaat 136380
ctccttgttt aggtgaatgt ggtcttctaa tgaaaaatca aaaggcgcta caccgtttct 136440
tttattgttt gtttcttttt taagtataac acaagttagt gaaaaagtca agatagttac 136500
tacaactatt gatagaagtt taattaggtt cttcataatt attctaactc cttaagttta 136560
ttttttattt tatctttgtc atagttgtat tgtttttccg tttctttgtt ttcatcatct 136620
tcttttttag catctatttc tctgtattta gcttcttcta ccttactgcc atctttctta 136680
ttaggttcat atttatctaa atatgaatta ggtttatttt taccattgta atttttactt 136740
ttatttttta aaaataacca aagtattatc attataataa gtaagatgat gatgctcaat 136800
actacagccc aaatattatt agtcattata gtctacctcc aaatagtttt tttatagctt 136860
ttaagttttc tgatgactca ttgtttatat gaatacctgt acttgaatcg aaaataacag 136920
cattatcaag taagtgttct ttaagttcat tttcataact tcctttacct acgacactac 136980
cataaccatc gtgtgttaaa tcagtcatat cagattcaac ttctaatact ctaaacgata 137040
ctctacgtaa aaatgatggg tttactaagt aaaaggatga tttaaaaaca tttaatcttt 137100
gataagaatg ttttatatta acaacaaacc cagtaagttt atcattataa cttgagtttg 137160
atagcttacc taaatataaa tttatactat accctttcgt ttctagagtt tgtatagcac 137220
taagcagtat agctcctcta taagcaagat tctcagggtc ttccatccaa cttatactag 137280
aattatagaa tacatcaata actttcttct ctgctttaac tctctgttga gacatcatag 137340
aattaggtaa accttttata gcgttaggta catgaggttg ataaccttca ggagccacaa 137400
ctggttttct ttttacagat ttatccattc tgaataatgc atctgtcatc tttttaagct 137460
taacaaccat atcataggac tctctatctc ctttaaccat taagttatag gcttcattaa 137520
agctatgagt gcctgtgaag tcgtagctac ctgtatctga tgaattgtcc ctacctgaaa 137580
ctctattctt ttttaaagca gaaaagaaat caggtagacc atcatattta attacattta 137640
attctgagtt atctattaat cgtctaccca ttgtttttcc tcctattcta gtcctagttt 137700
atccatgata gtgtcaaagt ccattgaatc actagatgaa ctttgagttt ttcttggttc 137760
ttgtttaggt tcttgtttga tacctaaaag attttttgtt gcttctgtat atctgttatc 137820
ttcaggtaaa gaactaataa attgattaat ttcatcttta ggtacagact tgaagatgat 137880
actttctaca acaaactcat cgtccattac tccatctaat ttacttccat taataattgc 137940
acgcattgaa aagacataag gtaatccttt ttcatcgttc tcatatctta atttttgtac 138000
aaagtttact aaatcctcat tacttgatag ttggtgttct accttattat cataatcaaa 138060
ttcaacttga gcaaaacggt ctaatgtagc tccatccagt tgctgtcttc ctacataaat 138120
gtggtctgct ccagttccca tagtattacc tgctgatact actctaaagt cttcatgtgc 138180
tgtcacacga ccaataggga agtcaaagta tttatttgca atagctgagt taagaattaa 138240
taatacttca gggatagatg catccatctc atctaggaag aataatcctc catttgtaaa 138300
tgctttataa aactgagttt catgaaactt accatttgca tcaataaatc ctgttaattt 138360
aaattcttga gtaattgcat tactgaaata gaaatctaag tctagagctt ctgctacttg 138420
ctctaataca tggttctttc ctgaacctgc tccacctttt aaaaacactg gaatattttg 138480
attaactagt tttaatatat cttgatatct ataatggaag attcctgaga tatctttaat 138540
tgttttacct tcttgttgta attcaatctt aactggtaaa ttattaagtt gctcctctac 138600
atattcttca atttgttttt taacatcagt aataattatt tctctactct cagttcctgc 138660
tttctctaca attgcatcca caattgcttg ttcataaggg ttagagtttt tctctcctag 138720
tttatctgct aagtctttcg ttgtctgcat ttgttgttct actaatctct ctaatctttc 138780
aatagtatct tgctttgcca tatttatcat tctcctttga tttgttatac atttattata 138840
atacaagtat tttcatttgt caacaacttt ctaaaacttt tttagttgtt aataaaaaaa 138900
ttaccttaca cctataactt aacatagggt aaggtaattg tcaacacttt tttaaaaata 138960
cattaattta aaaaagtcat caatgtcttt agttccatgt gtatccatat catacataaa 139020
catacaatta tatgtatgtt tattcactat ttctagcata ttgtgcatag aagttgcatt 139080
attgaattcc tctaaatcaa tagttatcgt aagttcttga ccttcataaa taatgtttgc 139140
tatataatat tttttaacac cttccattgt tccatgggaa gtttcattat gattaagaac 139200
ttctatacct agtgaaggta aataatctga aaaatagtat ttgcagaaat atataaaatt 139260
gtctgttctt ttagacacga gtactatccc catattttat atttctttct aatcttacat 139320
aatatgtttt aatcttttga acttctttgt ctactgcatc ttttcttcct aatcttgtag 139380
tatattttac aatattaaat atcatagaat caacaaaacc gtcataagaa aagtgttctt 139440
ctagaaaaga aataacatcc ttactacctt tatagtgctc aggtaaatgt gcatctactt 139500
gtatattata gtaatcttct aaaagaccta tactttcacc aagactagat aaagcataac 139560
ctaaatcatt ggaatcatta gaccattctt tagatactga taacgcatct tctataattg 139620
ttatttttaa tttatctaag taatcttcta cttgagcttg tgttttcata aattcttttg 139680
cattcattta ataacctcct aaattgtata aaaaaaacac cctgcttgga tacaagcaag 139740
gtgaaaaagg aaagatatta tggaagtgta ctatctaagt acacctcata atataacagt 139800
tttccttagt ctaaccctgt tgaaccaaac ccacctctag aactttcatt ttcaaaggta 139860
tctacaactt caatatcggg ataaacaaca ggtgctacta ctaattgagc tattttttta 139920
cctttttcga taaattgatg tctatctgat atattgtcaa caataacttt gacttcttga 139980
tgataaatag tatctactgt tcctataaca actcttttag gagtcttaac tgaaatacct 140040
gatttaggtc ttacttgggc ttcataccct tcttctaaat aaacagctac tcctgtagga 140100
actaatacag tactatgagg aggaattgtc atatcctcaa ttgcatataa gtcagctcca 140160
ctatctttag ggttagctct acttggaatt acagcatctt tgtgtattaa ctttactttt 140220
aatttattca ttctatatct cctttaattt ctgtatcttt tataattaga ttatcagaat 140280
cacttattac atttaagtta tcttcgacta attcatgtag gttattagta atatcttctt 140340
catacctgta acctacacga acataagctt tcaccctgac atctatatta acataacctt 140400
cttggaattt ttccatctct aacttccttt attataccat attgttatac ctttgtcaat 140460
taatctgaat agttcccttt agcaagttga tactttttgt gtaattcttc atataattct 140520
ctcatacctt catagtttct catatcatct tccaagaaac taagataatc taataataat 140580
ttagtctctt ctacttctaa agttataact ggtttgacca tttatgcaac ctccttaaat 140640
tcttctttat ttattttctt aatatctttt tctaatgctt cttttagttc attaggtaat 140700
ttatatgcat caattgattg ttgctgtcct aacacataac cattatctgt aatacgtatt 140760
tcaactgtaa accatgaatt atctaaatct tcttctaatc ttgctaataa tattaaacag 140820
ctattcttta gaattctatt agcatatcct ccaacacaat gagataacat tcgaccttca 140880
tcttttaatt tacttacagt atctgcagga aggaatttta cttttctacc atcttttaat 140940
ttataagttt tatcaattat tttttctaac ttattatcat acttagcttt aagttctgca 141000
tcatctaatt gttgttgaat ggattgtttt tcatctgtaa ctatatcatg ctctagcttc 141060
agtgaaaaag gagttaagtt aacactctct aatgttctat acccttctct gattagtatt 141120
gataaatcct gtaaatagtc aaggtaatat ctatctagtg catatcctgt tatacgttgt 141180
ctatcttgag catctacatc taaatagtga gtcatctttt tataattagc aaaagatata 141240
gataatattt catttacaat aggttttact tttaaagcat cagtaacata tcttgaatct 141300
cgaaccatta aaaaagtatc atcaaataat tggtgtaaat taacctcatt gtgtaaatga 141360
ttatagtact tatatagagt attagcaaat cttaagtaat taccttgctc aaatttattt 141420
aaagttagta attttttata agtctgtttt gtaagattga aagcttcatg aactttccat 141480
ttaggatttt taggtatatg aaatagtaat gcatttcttt caaataatcc aaattcctct 141540
aagttattta ttttgtcaat atttttaaca atatctgtta aagttgttaa gtaattagaa 141600
gttgaatttt ctcctataaa aatcctatat ttgtctcctc tataatttat atgaccataa 141660
acatctatat tatccggaca ccaactagaa aaatcaaaat tatggtgttc taatgtttgt 141720
tctattatct ttattataac ccctctattt aagttaggtt gtgagtaatt ttttaaaata 141780
acatttaata aaacagataa tgtcaattca tttttatatt cacttttact tatatcatct 141840
ttatacaaat ttaaagttag ttctttatta acaaggctat ctgttaagaa aactttaacc 141900
tcccctgttt taacatcaaa tgaactttta ttttctaaaa cccacttatt acccatatta 141960
tgtttatctc tgatatgtct aactttaaga ccgaaagatg aattattctc agtacctgga 142020
tgcatgtacc aagcactact atacaatgaa tctgacattt ccttataata cttactagag 142080
cctttttctg tatcttcatt catataagaa gtaatagatg attttattaa accgtactta 142140
ccttggtcta gaatatccat aatatcatca tttaaattat ctactacttc cttatactca 142200
tctaattgtc tagcttcata cccccataat cgggtttcat ttcctaattc tttgattttt 142260
tcttctgcat aacctttaga ttttatttgt cttctgctct tattaccata taaaggaaat 142320
tcttttcttt cttctctact ggactcaata tattctttgt aatttcttcc tttattttct 142380
tcaactacac cttcaactaa tttttcaact gtttcataag gattacctgt aaagtttgtt 142440
acttctttat taccacatag tgctaagaat aaatgtattt ctgtagcagt atcaaaacta 142500
aatatattat gaatatctct aaataattcc ttagagccta agttaattat attatttttc 142560
ttcttcttaa ggaatacatc ttcttctcct atgtagatac atcctttatt aactttaggt 142620
aaattaataa tttcttgttc tgttaatcct ttttgtttat a 142661
Claims (7)
- 황색포도상구균에 대한 사멸능을 갖고, 서열번호 1로 표시되는 전장 유전체를 갖는 것을 특징으로 하는 시포비리대 과(Siphoviridae)의 박테리오파지 SAP27(KCTC 14076BP).
- 삭제
- 제1항에 있어서, 상기 박테리오파지 SAP27은 황색포도상구균(Staphylococcus aureus), 스타필로코쿠스 카프래(Staphylococcus caprae), 스타필로코쿠스 페트라시(Staphylococcus petrasii), 스타필로코쿠스 호르미니스(Staphylococcus horminis), 스타필로코쿠스 루그더넨시스(Staphylococcus lugdunensis), 스타필로코쿠스 해모라이티쿠스(Staphylococcus haemolyticus), 스타필로코쿠스 워네리(Staphylococcus warneri), 스타필로코쿠스 자이로서스(Staphylococcus xylosus) 및 스타필로코쿠스 에피더미디스(Staphylococcus epidermidis)로 구성된 군에서 선택된 1종 이상의 균주에 대한 사멸능을 갖는 것을 특징으로 하는 박테리오파지 SAP27.
- 제1항 또는 제3항의 박테리오파지 SAP27를 유효성분으로 포함하는, 아토피 피부염의 치료용 약학적 조성물.
- 삭제
- 제1항 또는 제3항의 박테리오파지 SAP27을 포함하는 항생제.
- 제1항 또는 제3항의 박테리오파지 SAP27을 포함하는 소독제.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100759988B1 (ko) * | 2006-08-04 | 2007-09-19 | 주식회사 인트론바이오테크놀로지 | 황색포도상구균에 특이적인 항균 단백질 |
| KR101643235B1 (ko) * | 2015-06-03 | 2016-07-27 | 서울대학교산학협력단 | 황색포도상구균에 대해 숙주감수성을 나타내는 박테리오파지 시포비리데 패밀리 sap4 및 이를 함유하는 조성물 |
| KR20180042748A (ko) * | 2016-10-18 | 2018-04-26 | 주식회사 옵티팜 | 신규한 포도상구균 특이 박테리오파지 sa7 및 이를 포함하는 항균 조성물 |
| KR20180074584A (ko) * | 2016-12-23 | 2018-07-03 | 주식회사 옵티팜 | 신규한 포도상구균 특이 박테리오파지 sa3 및 이를 포함하는 항균 조성물 |
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- 2021-12-15 KR KR1020210179590A patent/KR102418861B1/ko active IP Right Grant
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100759988B1 (ko) * | 2006-08-04 | 2007-09-19 | 주식회사 인트론바이오테크놀로지 | 황색포도상구균에 특이적인 항균 단백질 |
| KR101643235B1 (ko) * | 2015-06-03 | 2016-07-27 | 서울대학교산학협력단 | 황색포도상구균에 대해 숙주감수성을 나타내는 박테리오파지 시포비리데 패밀리 sap4 및 이를 함유하는 조성물 |
| KR20180042748A (ko) * | 2016-10-18 | 2018-04-26 | 주식회사 옵티팜 | 신규한 포도상구균 특이 박테리오파지 sa7 및 이를 포함하는 항균 조성물 |
| KR20180074584A (ko) * | 2016-12-23 | 2018-07-03 | 주식회사 옵티팜 | 신규한 포도상구균 특이 박테리오파지 sa3 및 이를 포함하는 항균 조성물 |
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