KR102334893B1 - 신규한 캠필로박터균 특이 박테리오파지 opt-cj1 및 이를 포함하는 항균 조성물 - Google Patents

Abstract

본 발명은 신규한 캠필로박터균 특이 박테리오파지 OPT-CJ1에 관한 것으로서, 더욱 상세하기는 상기 캠필로박터균 특이 박테리오파지 OPT-CJ1을 포함하는 항균 조성물에 관한 것이다. 본 발명에 따른 박테리오파지 OPT-CJ1은 캠필로박터균에 대한 특이성이 매우 높고, 캠필로박터균에 감염하여 캠필로박터균 내에서 증식함으로써 용균 활성이 우수하며, 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 OPT-CJ1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는바, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 활용될 수 있다.

Description

신규한 캠필로박터균 특이 박테리오파지 OPT-CJ1 및 이를 포함하는 항균 조성물{Novel Campylobacter specific bacteriophage OPT-CJ1 and antibacterial composition comprising the same}

본 발명은 신규한 캠필로박터균 특이 박테리오파지 OPT-CJ1에 관한 것으로서, 더욱 상세하기는 상기 캠필로박터균 특이 박테리오파지 OPT-CJ1을 포함하는 항균 조성물에 관한 것이다.

일반적으로 캠필로박터(Campylobacter)는 그람음성의 세균으로 캠필로박터균에 의한 식중독은 국내뿐만 아니라 해외에서도 발병 비율이 높은 감염병에 속하며 살모넬라, 바이러스, 세균 독소에 이어 식중독을 가장 많이 일으키는 것으로 나타나 주요 병원체로 관리가 요구되고 있다. 그 중에서도 캠필로박터 제주니(Campylobacter jejuni)는 주로 온혈동물의 장관 내에 존재하며 동물성 식품을 매개로 인수공통감염병을 일으킨다. 발열, 두통, 근육통, 무기력증 등의 전구증상을 보이며 구토, 복통, 수양성 설사 증상이 나타난다. 체온이 높은 가금류의 장내에서 증식이 쉽게 일어나기 때문에 오염된 육류 중 특히 가금류의 섭취가 식중독의 주요 원인으로 나타나며 주로 여름철에 식중독이 많이 발생한다. 최근 2013년에서 2017년에 발생한 식중독 발생 건을 보면 5년간 총 67건으로 2,458명의 환자가 발생하였으며 이중 45%가 7, 8월에 집중되었다. 여름철 기온이 높아 캠필로박터균 증식이 쉽게 일어났으며, 삼계탕 등 보신용으로 닭요리 섭취가 증가하기 때문인 것으로 분석된다(식약처, 2018). 또한 유럽에서 캠필로박터증이 많이 발생되고 있는데 이는 닭고기 요리를 즐겨먹는 문화가 주 요인 중 하나로, 식중독 발생 보고의 40%가 닭과 칠면조에서 나타났다. 2014년 캠필로박터 식중독 발생건수는 444건으로 전체 식중독 발생 건수의 8.5%를 차지하였다. 미국의 경우 식중독 원인체 집중 관리 대상으로 캠필로박터를 지정하고 있다. 미국 질병관리본부 통계자료에 의하면 2014년 식중독 발생건수 중 캠필로박터균에 의한 식중독 발생건수가 전체의 5%를 차지하였다.

오염된 육류로 인한 캠필로박터균 원인 식중독 예방을 위해서는 생산, 가공, 유통 및 최종 소비자에 이르기까지 각 단계에서 적절한 통제가 필요하다. 양계장에서는 사육시설의 위생관리를 철저히 하고, 생산 및 가공공장에서는 교차오염 방지에 주의하여 HACCP 등 위생관리 프로그램 시행이 진행되어야 한다. 적합한 가공방법과 온도관리 지침이 필요하다. 급식소에서는 칼, 도마 등의 조리도구 및 용기의 세척과 소독을 철저히 하여 교차오염을 방지해야 한다. 그러나 현재 식품용 살균제로 허용된 소독제의 효능으로는 세균 오염을 예방하기가 쉽지 않으며 고농도로 사용할 경우 인체에 유해한 영향을 미칠 수 있다. 이에 따라 자연 친화적 방식의 인체에 무해한 소독제의 개발이 필요하다.

한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지의 활용이 크게 주목을 받고 있다. 자연 친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.

이에 본 발명자들은 박테리오파지를 기존 항생제의 대체 물질로 활용하기 위하여, 캠필로박터균 특이 박테리오파지를 분리하였고, 분리된 박테리오파지가 캠필로박터균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하게 되었다.

따라서 본 발명의 목적은 캠필로박터균 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-CJ1(수탁번호 KCCM12723P)을 제공하는 것이다.

본 발명의 다른 목적은 상기 박테리오파지 OPT-CJ1을 포함하는 항생용 조성물을 제공하는 것이다.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-CJ1을 포함하는 사료 첨가용 조성물을 제공하는 것이다.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-CJ1을 포함하는 사료를 제공하는 것이다.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-CJ1을 포함하는 소독제를 제공하는 것이다.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-CJ1을 포함하는 세척제를 제공하는 것이다.

본 발명의 또 다른 목적은 상기 박테리오파지 OPT-CJ1을 개체에 투여하는 단계를 포함하는 캠필로박터균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.

상기 목적을 달성하기 위하여, 본 발명은 캠필로박터균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-CJ1(수탁번호 KCCM12723P)을 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는 항생용 조성물을 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는 사료 첨가용 조성물을 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는 사료를 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는 소독제를 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는 세척제를 제공한다.

또한 본 발명은 상기 박테리오파지 OPT-CJ1을 개체에 투여하는 단계를 포함하는 캠필로박터균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.

본 발명에 따른 박테리오파지 OPT-CJ1은 캠필로박터균에 대한 특이성이 매우 높고, 캠필로박터균에 감염하여 캠필로박터균 내에서 증식함으로써 용균 활성이 우수하며, 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 OPT-CJ1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는바, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 활용될 수 있다.

도 1은 본 발명에 따른 박테리오파지 OPT-CJ1의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 2는 본 발명에 따른 박테리오파지 OPT-CJ1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 3은 본 발명에 따른 박테리오파지 OPT-CJ1의 캠필로박터 제주니에 대한 사멸능을 분석한 결과를 나타낸 도이다.
도 4는 본 발명에 따른 박테리오파지 OPT-CJ1의 pH 안전성을 확인한 결과를 나타낸 도이다.
도 5는 본 발명에 따른 박테리오파지 OPT-CJ1의 열 안정성을 확인한 결과를 나타낸 도이다.

이하, 본 발명을 상세히 설명한다.

본 발명은 캠필로박터균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-CJ1(수탁번호 KCCM12723P)을 제공한다.

본 발명의 박테리오파지 OPT-CJ1은 하수처리장으로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 박테리오파지 OPT-CJ1로 명명하고 2019년 10월 08일 국내 기탁을 완료하였으며, 2020년 05월 21일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 국제 기탁하여, 기탁번호 KCCM12723P를 부여받았다.

본 발명에서, “박테리오파지(bacteriophage)”는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.

본 발명에서, “캠필로박터균”은 그람음성간균으로서, 활발한 선회운동성을 가지는 균을 의미한다. 상기 캠필로박터균은 미호기성의 특징을 가진다.

본 발명에서, 상기 캠필로박터균은 캠필로박터 제주니(Campylobacter jejuni), 캠필로박터 피터스(Campylobacter fetus), 캠필로박터 라리(Campylobacter lari), 캠필로박터 파이로리(Campylobacter pylori), 캠필로박터 콜라이(Campylobacter coli), 캠필로박터 컨시서스(Campylobacter concisus), 캠필로박터 업살리엔시스(Campylobacter upsaliensis), 캠필로박터 라니에네(Campylobacter lanienae), 캠필로박터 쇼애(Campylobacter showae) 및 캠필로박터 무코살리스(Campylobacter mucosalis) 로 이루어진 군에서 선택되는 1 이상인 것이 바람직하며, 더 바람직하게는 캠필로박터 제주니(Campylobacter jejuni)이나, 이에 제한되지 않는다.

즉, 상기 박테리오파지 OPT-CJ1은 캠필로박터균, 특히 캠필로박터 제주니에 대해 용균활성이 탁월하다.

또한, 상기 박테리오파지 OPT-CJ1은 230 내지 250 nm의 크기로, 정이십면체의 머리와 수축성 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속한다. 상기 박테리오파지 OPT-CJ1은 캠필로박터균에 대한 항균능뿐만 아니라, 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다. 보다 상세하게는, 상기 박테리오파지 OPT-CJ1은 pH 3 내지 pH 11의 범위에서 안정하며, 특히, pH 4 내지 11의 범위에서는 2시간 동안 안정한 것이 바람직하나 이에 제한되지 않는다. 또한 상기 박테리오파지 OPT-CJ1은 온도 10 내지 60 ℃의 범위에서 60분까지 모두 안정하나, 이에 제한되지 않는다.

본 발명의 박테리오파지 OPT-CJ1은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 OPT-CJ1은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70%이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.

상기와 같은 캠필로박터균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 OPT-CJ1을 캠필로박터균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 OPT-CJ1을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.

또한, 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는, 항생용 조성물을 제공한다.

본 발명에서, “항생용 조성물”은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.

본 발명의 박테리오파지 OPT-CJ1은 기존 항생제에 비하여 캠필로박터균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.

또한, 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는, 사료 첨가용 조성물을 제공한다.

축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 OPT-CJ1을 이용할 수 있다.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조 상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 중량% 내지 10 중량%, 바람직하게는 0.1 중량% 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.

본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis), 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 동물의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae) 및 사카로미세스 세레비지에(Saccharomyces cerevisiae)로 구성된 군으로부터 선택될 수 있다.

본 발명의 박테리오파지 OPT-CJ1을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.

본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.

또한, 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는, 소독제를 제공한다.

다양한 캠필로박터균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 OPT-CJ1을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.

또한, 본 발명은 상기 박테리오파지 OPT-CJ1을 포함하는, 세척제를 제공한다.

본 발명의 박테리오파지 OPT-CJ1은 다양한 캠필로박터균에 특이적 사멸능을 가지므로, 상기 캠필로박터균에 노출되었거나 노출될 가능성이 있는 가축의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.

또한, 본 발명은 상기 박테리오파지 OPT-CJ1을 개체에 투여하는 단계를 포함하는, 캠필로박터균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.

상기 캠필로박터균은 캠필로박터 제주니(Campylobacter jejuni), 캠필로박터 피터스(Campylobacter fetus), 캠필로박터 라리(Campylobacter lari), 캠필로박터 파이로리(Campylobacter pylori), 캠필로박터 콜라이(Campylobacter coli), 캠필로박터 컨시서스(Campylobacter concisus), 캠필로박터 업살리엔시스(Campylobacter upsaliensis), 캠필로박터 라니에네(Campylobacter lanienae), 캠필로박터 쇼애(Campylobacter showae) 및 캠필로박터 무코살리스(Campylobacter mucosalis) 로 이루어진 군에서 선택되는 1 이상인 것이 바람직하며, 더 바람직하게는 캠필로박터 제주니(Campylobacter jejuni)이나, 이에 제한되지 않는다.

본 발명의 캠필로박터균의 감염으로 인한 질병은 캠필로박터 감염증, 식중독, 급성위장염, 말단회장염, 패혈증 또는 수막염일 수 있으나, 이에 제한되지 않는다.

따라서 본 발명의 방법은 상기 캠필로박터균의 감염으로 인한 질병이 발생한 개체 또는 발생 위험이 있는 개체에 박테리오파지 OPT-CJ1을 투여하는 단계를 포함한다.

본 발명에서, "개체"는 캠필로박터균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다.

상기 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.

상기 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위, 앵무새 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.

본 발명의 방법에서 상기 박테리오파지 OPT-CJ1 또는 이를 포함하는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.

본 발명의 방법에서 상기 박테리오파지 OPT-CJ1 또는 이를 포함하는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.

본 발명의 방법에 투여되는 상기 박테리오파지 OPT-CJ1의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.

본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술 분야에서 통상적으로 사용되는 의미를 갖는 것이다.

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.

실시예 1. 신규한 박테리오파지의 분리 및 배양

1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리

캠필로박터 제주니에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 진행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 하수처리장으로부터 채취하였으며, 박테리오파지 분리에 사용된 캠필로박터 제주니는 ㈜옵티팜에서 채취한 야외 시료로부터 분리 동정된 것을 사용하였다.

구체적으로, 채취한 시료를 균질화 한 후 캠필로박터 제주니와 함께 42℃에서 48시간 동안 배양하였다. 상기 배양액을 3,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.2 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다.

전배양된 캠필로박터 제주니 150 μl를 취해서 멸균된 튜브에 넣고 3 mL의 NZCYM 탑 아가[NZCYM 배지 (카제인 10 g/L; 카사미노산 1 g/L; MgSO₄ 0.98 g/L; NaCl 5 g/L; 효모 추출물 5 g/L) + 0.6% 아가]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% NZCYM 아가 플레이트에 중층하였다. 이를 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 42℃에서 48시간 동안 배양하여 박테리오파지의 유무를 확인하였다.

박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(캠필로박터 제주니) 배양액 150 μL에 혼합한 후 NZCYM 탑 아가 3 mL를 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% NZCYM 아가 플레이트에 중층하여 방치한 후 42℃에서 48시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM완충액(NaCl 5.8 g/L; MgSO₄7H₂O 2 g/L; 1M Tris-HCl(pH7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 NZCYM 탑 아가와 세균배양액 500 μL와 혼합한 뒤 90 mm 지름의 NZCYM 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 42℃에서 배양하였다. 배양이 종료된 후, NZCYM 아가 플레이트에 5 mL의 SM 완충액을 가하고 실온에서 4시간동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 3,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다.

1.2 박테리오파지의 대량 배양 및 정제

상기 실시예 1.1에서 확인한 캠필로박터 제주니 특이적 박테리오파지를 대량 배양하기 위하여, 실시예 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x10⁸ PFU/mL 로 희석한 후 전배양된 캠필로박터 제주니 1.0x10⁹ CFU/mL와 MOI(Multiplicity of infection)를 0.1이 되도록 혼합하여 42℃에서 48시간 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다.

분리된 박테리오파지를 “박테리오파지 OPT-CJ1(Bacteriophage OPT-CJ1)”으로 명명하고, 2019년 10월 08일 국내 기탁을 완료하였으며, 2020년 05월 21일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 국제 기탁하고, 수탁번호 KCCM12723P를 부여받았다.

실시예 2. 박테리오파지 OPT-CJ1의 전체 유전자 분석

박테리오파지 OPT-CJ1의 전체 유전자를 분석하기 위해, 박테리오파지 OPT-CJ1 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5%(w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3 M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2 회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL가 되도록 TE 완충액(Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSll 를 이용하여 유전자 시퀀싱을 시행하였다(마크로젠, 한국). 시퀀싱 결과로 얻은 박테리오파지 OPT-CJ1의 유전자 맵은 도 1에 나타내었다.

도 1에 나타낸 바와 같이, 박테리오파지 OPT-CJ1의 전체 유전자의 크기는 130,508 bp이며, GC함량이 24.62%, ORF는 175개임을 확인하였다. 분석한 박테리오파지 OPT-CJ1의 전체 유전자 서열을 서열번호 1로 나타내었다.

실시예 3. 박테리오파지 OPT-CJ1의 형태학적 특성

박테리오파지 OPT-CJ1의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 탄소 코팅 운모 플레이트(carbon-coated mica plate)(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30초 내지 60초간 염색하고 건조시킨 후, 투과전자현미경(Tecnai G² Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 2에 나타내었다.

도 2에 나타낸 바와 같이, 박테리오파지 OPT-CJ1은 230 nm 내지 250 nm의 크기로, 정이십면체의 머리 및 수축성 꼬리를 갖는 마이오비리대(Myoviridae)에 속함을 확인하였다.

실시예 4. 박테리오파지 OPT-CJ1의 다양한 세균에 대한 감염성 및 사멸능 조사

박테리오파지 OPT-CJ1이 다양한 세균에 대하여 용균 활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 1에 나타내었다.

표 1에 나타낸 바와 같이, 캠필로박터 제주니 및 다른 미생물을 대상으로 감수성 조사를 수행한 결과, 박테리오파지 OPT-CJ1은 캠필로박터 제주니에 특이적인 용균활성을 나타내는 것을 확인하였다.

또한 박테리오파지 OPT-CJ1의 캠필로박터 제주니에 대한 사멸능을 분석하였다. 구체적으로, 세균배양액(5.0x10⁶ CFU/mL) 10 mL를 준비하였다. 세균 배양액의 농도가 1.0x10⁸ PFU/mL 되는 박테리오파지액을 1 mL 넣어 MOI 2로 접종한 실험군과 박테리오파지액을 넣지 않은 시료를 대조군으로 하여 실험을 진행하였다. 42℃에서 48시간동안 배양하며 12시간, 24시간, 48시간 마다 세균수를 측정하였다. 박테리오파지 OPT-CJ1을 이용한 캠필로박터 제주니에 대한 사멸능력의 분석 결과는 도3에 나타내었다.

도 3에 나타낸 바와 같이, 박테리오파지 OPT-CJ1을 첨가하지 않은 대조군의 경우 세균의 수가 유지되고 있음을 알 수 있다. 반면, 박테리오파지 OPT-CJ1을 첨가한 실험군의 경우, 초기 세균 수에 비해 10⁶ CFU/mL 가 감소하여 세균이 효과적으로 사멸된 것을 알 수 있다. 상기 결과는 박테리오파지 OPT-CJ1이 캠필로박터 제주니에 대한 사멸능이 우수하다는 것을 의미한다.

실시예 5. 박테리오파지 OPT-CJ1의 pH 안정성 조사

박테리오파지 OPT-CJ1의 pH 에 대한 안정성을 확인하기 위하여, 다양한 pH 범위(pH3,4,5,6,7,8,9,10,11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 OPT-CJ1 배양액을 5.0x10⁸ PFU/mL가 되도록 준비한 다음 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2 시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계 희석하여 소프트 아가 오버레이법에 의한 역가 측정을 수행한 결과를 도 4에 나타내었다.

도 4에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-CJ1은 pH 4 내지 11의 범위에서는 2시간 동안 매우 안정한 것을 확인하였다. 이를 통해 박테리오파지 OPT-CJ1은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.

실시예 6. 박테리오파지 OPT-CJ1의 열 안정성 조사

박테리오파지 OPT-CJ1의 열 안정성을 확인하기 위하여, 다양한 온도 범위(10,20,30,40,50,60℃)에서 일정시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 OPT-CJ1 배양액(8.0x10⁷ PFU/mL) 5 mL를 멸균된 튜브에 분주하고 10, 30 및 60 분 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계 희석하여 소프트 아가 오버레이법에 의한 역가 측정을 수행한 결과를 도 5에 나타내었다.

도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 OPT-CJ1은 10 내지 60℃의 범위에서 안정한 것을 확인하였다. 이를 통해 박테리오파지 OPT-CJ1은 내열성이 우수한 박테리오파지임을 알 수 있다.

종합적으로 본 발명자들은 박테리오파지 OPT-CJ1이 캠필로박터균, 특히 캠필로박터 제주니에 대한 특이성이 매우 높고, 캠필로박터균에 감염하여 캠필로박터균 내에서 증식함으로써 용균 활성이 우수하며, 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 OPT-CJ1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서 본 발명의 박테리오파지 OPT-CJ1은 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 활용될 수 있다.

이하, 제제예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 제제예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 제제예에 의해 제한되는 것으로 해석되지 않는다.

제제예 1. 사료 첨가용 조성물

박테리오파지 OPT-CJ1 1x10⁸ PFU/mL

비타민 믹스 100 mg

미네랄 믹스 100 mg

스테아린산 마그네슘 2 mg

통상의 사료 첨가제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.

제제예 2. 소독제 조성물

박테리오파지 OPT-CJ1 1x10⁹ PFU/mL

에탄올 적량

멸균 증류수 적량

pH 조절제 적량

통상의 소독제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.

제제예 3. 세척제 조성물

박테리오파지 OPT-CJ1 1x10⁹ PFU/mL

에탄올 적량

효소 복합물 적량

멸균 증류수 적량

통상의 세척제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.

이상, 본 발명내용의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시 형태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의해 정의된다고 할 것이다.

한국미생물보존센터 KCCM12723P 20200521

SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Campylobacter specific bacteriophage OPT-CJ1 and antibacterial composition comprising the same <130> 1_87P <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 130508 <212> DNA <213> Unknown <220> <223> bacteriophage OPT-CJ1 <400> 1 acagctacta aacttaatgc ttataaaaaa gaactagcta atagaataac tatagcaaca 60 aaattaaaaa ggagaacaaa tgtataatta tataaaatat tttgaaagag atgatacagc 120 taatttggat aatgttataa aaaaacaaat acaaaaagaa tataacaatc atcatgaagt 180 taaaaatcat cttaatagaa tagaagcaaa tgaaaaatta ataaaatcat taaaggaata 240 taaatgaaat taatagttga acaaccatta aagttaaaag gttctataga attaaatgaa 300 tctgaggata aaaaaaatta ttatatacaa ggaatttttg caacaattaa tcaaaaaaat 360 ataaatggta gggtatatcc tagacctatt tgggaaagtg ctgttaattc ttatcaacat 420 cacattacta ctcctactac aaattcttta atggagtatc agcatccaaa tagacaatat 480 gttgatcctc ttgaagctgt tgcaagaata gtagacctta ggatagaagg tgattatgtt 540 ttaggtaaag ctaaattatt agataatcca aaagcaaatc aattaaaaaa cttaattgat 600 gaaggcatat ctataggtgt atcaagcaga ggttgtggag agttaatgaa tggtacagtt 660 acactttacg aacttattac atttgatata gttccaaatc catctgatta caatgcccac 720 actaaaggtt taaacgaatc ttttgataat ggaatattaa aagataaaaa ttatgttaaa 780 aacaaagatg gtgtgttagt agaatcaatt gaaaatgata ataatataaa tatgagtata 840 acttctcaat ttgcagagtt tttatcaaaa ttataaagga agaaacatgg aagaactttt 900 aagtaagctt gataaaaatg tttttacacc tgaagttgtt aaggaaatac aagaattatt 960 tgaagctgct gttgataata aagtagcaga agctttaaaa cttgcagatg cccatacaaa 1020 tgaagttaat gaacattttg aaagtgaagt taaaatgata aaagaaagtg ctgaaatgta 1080 taaaactaat cttaaaaaaa gaaacgagaa acttatacat gacgctatta caaaaatcaa 1140 aaaacattat aatggtatag ttgaaaatat cattaaagaa aaagttgatg aatttgtaaa 1200 acaaggttct aaaaatcttg aaaaacttgt tgagagtagt aacaaagacc ttataggtgc 1260 ttgtgaaaaa actgcagata aagcaggtgg ctcaaaagaa tttatcaaaa gaatgaatga 1320 aaatgctaaa aaagaaaaag aaaatagaag actagaattt caaaataaag agcttcaaag 1380 aaaattagat ttagcaaata aaaaccgtat atacgaaagt gttaaaaata ctttaagtgt 1440 tacaggtaaa gatatgtttg atgaacttgc aaaaaatata gcatatacag gaaatgaatc 1500 ttatagagaa aacttagaat caattgcttc taaagttaaa attaagtcaa atataacaag 1560 aagtggtaga tcagctttat ctgaatctat taatgataaa aacaataacc atgctaaaac 1620 aggttatagt aattttttat aaataaaata tattaaataa aggagaaaaa aatatggctg 1680 gtaaatattt attagacgag tcaacaaaag aaaaattcat taaaagtgag ttatacccac 1740 aaattagtga atctgaatta aaccttatga aaactgttct tgaaaatcaa ggaaaagaag 1800 ttgatatgct tatggaaagc actgtaagtg gagatatcgc acaatttaca ccaattttag 1860 ttccagtaat tcgtagagcg ttgcctatgt taataggcac tgaaatcgca ggcgttcaag 1920 ctcttaaaac tccaactgct tacttgtatg caatgactcc acattatgta ggtgatggta 1980 ttaatggtgt aaatccaaat actaatgcta ttgttttaaa acttaaaaca gaatctgcaa 2040 ataaaaatga ctttaattat actggaaatc ctattgaagt ttcatttaag acagctacaa 2100 ctgttaaagg tgaaatagta tatagtgaaa aacaagcagg tacagatgat gtggtaaatg 2160 tattacttcg tttaaaatct ggctcaactg gttctgttac tattggtgat caagttgata 2220 aagcagcttc atttactact aaaaaagcaa ctgttgaggc tgtatataca aacgaagctt 2280 tatggttaaa agttcttaaa aactatacag gtccttattc aactgctgca ggtgaagctc 2340 ttgcaaaaga tatgaaagaa ttaggtatta gtgtacaaag aattttagca gaagctaaaa 2400 ctagaaaagt aaaaggcgta tacactcttg aaatgttaca agacttaaaa gctcaacata 2460 acttagatgc tgaaaaagaa ttatcagcta ttttaagttc tgaagttgct cttgaaattg 2520 atagaactat tatagaaaaa gttaatgaag tagctacagt tgcaactgac ttcgatatta 2580 gtagtgctga tggtagatgg tttattgaaa aagctagagg acttagtatg agaattacta 2640 atgaagctag agaaatcggt agacaaacta gaaaaggtgg aggtaacaaa ttagtagttt 2700 ctcctaaagt tgctacaatc ttggatcaaa tcggttcatt tgttttatct cctgcaggaa 2760 gcaaaatcaa ttctatcaat agtggtatta aaccaaatgt tggtaagttt gataatcgtt 2820 acgatgtaat cgttgacaac tttgctgagt ttgaatattg tactgttgca tataaaggat 2880 caaactttga tgctggtgta ttctttgctc catataacat tacattacaa caaaacttaa 2940 tagaccctac aagtggtcaa cctgcaatga ttttaaataa cagatatgat gttgttgctg 3000 gtccattgca cccagaagca tatttcagaa catttgctgt taatttaaat agcttcataa 3060 tttcttaatt taataactag ggttaaatac cctagttcta tcaataatat ataacacaaa 3120 gattttatac aaaaattact acgaacaaaa gttaaaattc aaacaccgca cttaagaaag 3180 aaactaaaat ttaaaattta aaaatcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3240 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aataaaatat attatataag 3300 taagaaaaaa attttttaaa aaattttttt gtaaaatttt tattttaatt ttttttaata 3360 tttttaatta aatatatact atataaaaat atttttttta tattatttca agtaaaatat 3420 gatataatat atattaacaa taaatatata attaaataaa aggattgata tgaatgaaat 3480 taatgttgta aaaacatatg ttaatggtga aatagcatta tgtaatttag caagtattaa 3540 tttgtatgag tatgatttat tgaataaaga agaaaagtat aaattaatat atgatatagt 3600 aagtacaatg gataatacta tagatttagc tcattacatg gttaaagacg cacaaacatc 3660 aaataaaaag tatagatatt taggtatagg tgtttcaaat ctagctgtat tattagctaa 3720 acataaaata atttttgatt cacaagaaag cttagagttt caagctgaat tatttgatga 3780 tatattatat aattgtgtaa aagcaagtat gaacttagct attgaaagag gaaaagcaga 3840 aggttttaat gaaacaaaat gggctaaagg aatttatcct tatttaatag gaaatgaaaa 3900 agcaaaatct ttaattaagt tcaaacctga taaaaacaaa tggaatgaat taatggaaaa 3960 agtaaaacaa tgtggattaa gaaactgtgc tttgatggct atagctccaa ctgcaacatc 4020 aggtcgtagc ataaacgctt ctgaaagtat agaacctata caaaagctat tgtacaaaga 4080 agatggaaat atcaatgtta aaacattagc acctatgttt aaagaacaca atgaatatta 4140 taaattagca caagaatgta atcctataat gttaataaaa gccgcagctg ttagacaatt 4200 atttttagat caaagtcaaa gtgttaatat gtattcttat acatataata acgagccaaa 4260 ttatatacaa aaaagttcaa acaaattgtc tttattacat atgtatgcac atcagttagg 4320 tttaaaaact ttatattatt ttaaatcaga aaaagacaat ggcgttgaag cagaatgtga 4380 atcttgctcg taatataaat atattataat caaatattaa ggaaaattaa tggcaacaca 4440 tgatcaaatg caacagctta ttaaagtttg tttaaaatgt ggtattaatg aatcagttgt 4500 tacctattca aaattaatga gaagcggttt tgtagtttta tctggaaata atgaaagttt 4560 taaaaaatta aatgaaagtg aaacttgttt tgaagcaaaa caagttaatg aaagttcttg 4620 gcttataaaa gataaaacta aaaaattatc taatgatgaa tgggataatt tgaaaaatta 4680 ttatgacaaa aataatactt ttaacaagct tgataatatt aaattaaatc aaatatctga 4740 agaagtcctt aaagatattt ggtataaaaa tgatttagaa gaaaaaagaa acgaattact 4800 aaacataata aatgatttaa actataattc taaatcagtt caaaaaattg ttgaaagtgt 4860 aaaagaatca gatgatgagt atgttttaaa ctcaatagta acaaatttaa tttttattaa 4920 aaacaaggag aattaatgaa aaaaggtatt agtttaaacg aagctattaa aagaagagct 4980 aaaggtttaa gtaaaagaga tgttgcatct ttaaatgaag ctattaaaag aagagctaaa 5040 ggtttaagta aaaacaaagg tatatctata aatgaagctg taaaaaaagg gcatgttaaa 5100 tatttaagca aaaaactatc tataaatgaa tctgaaataa atggattaaa agaagcttta 5160 gaaaacatgg aagaatttgt agatgataat attatgggtt ctgttgtagg taaagattat 5220 gttatatctg tatttgataa agtatgtatt atattagtta atggtacaga acctttttta 5280 atagaaagag aagatgttga ggaagaagaa caaaatctaa tagatgatgt ttttgaaact 5340 ttaaatttag aactttctga tgacgaagaa gtaggctatg aagaaggatt agaagttgtt 5400 tcagatgata acattgatga agatgattca aaacctgaag aaattaatga aagtaaagta 5460 aaaaaaggaa gaagaaaatc aaaataaggt ggtaagttcc accttatttt ataaggtaaa 5520 ataatggcaa atagaagtaa agcaaaagga aatagtttcg aaagagttgt agctaaaatg 5580 ctatctgaaa attattcaga tatttttggt gtaaatcaat catttcaaag aaatatatct 5640 agtggttcta tatttggtgg aactaatcat cacagaggta aaaacatttt aaatgaacat 5700 acattttatg ctgctgatat tatatgtcca aatgaattta aatacactat agaatgcaaa 5760 cattatgcta atgcaccttc tttaaatagt atatttttac aagaatgttc agaatgggat 5820 aaatggatta atcaagttga atcagattgt gaagtatcaa aaaaacttcc tatgctaatt 5880 gttaaatatg ataaaattaa accatttgta tttattaaag aagaatttaa gaatattgtt 5940 gtaaaatata aaaattacaa tgtttataat tttgaaacat ttataaaaga aaacaaaatg 6000 gagttaataa atgtatagta aatatcttta cgaagcagca gattatcagt ttgaaactac 6060 agatcaagat atagataaat cttatttaaa atttaataaa gaattaaata ctaaattgtc 6120 taattgtata aaatataatt ttggaaatat tttatctaat acatttcaat caaaatatga 6180 tgatataaat gttataatta aactagaaga tactggaaat tataaagctt attctaattc 6240 tattgacaac atagataaat ttattatata tttagataca ttatatcaaa acgaataagg 6300 atttttaatg actacttctg gtgatattgc aggtgtttca aatagacttc ctttgaaaaa 6360 aggtaaaaca aactctataa aaccaaaaat aataaaaaat aaatcttaca aaactttaac 6420 tttaaagaaa tttaagtagc ttataagaaa aaataagata taatatctat tataataaag 6480 tatattatat cttataatat ccttttaaat attaaatgaa aggaatatat ggctacatca 6540 acattatatg atgaaaaagg aaaagtaaag ctacagtgga taaaaaatgg tggaaaagct 6600 ataccttcag aagatgtttt agaaagtatt aaattagctt gtaaagaaat aggaaaatac 6660 agttttaaac caaaacaaac tctaaaagga ctaactaaag attcaataac tgtttataac 6720 atatctgata tgcactttgg tatgttagct ttaaaagaag aaacaaatga tagtgattgg 6780 aacttagaaa tagctgataa aactttagat caattatcaa ctgaattaat caatggtgct 6840 aatagaacag aaagttgtat catttgtaat ttaggtgact taattgatat caacgatttt 6900 actcacaaaa caccaaaaag tggaaatgtt ttagatgtgg ataaaaaaat accacaaata 6960 ctatcagttg cttacaattc aattattaaa atgatttata aagcattaga aaaacataaa 7020 tatgttcatt acataaatat tccaggaaac catgatatcc taccatcaat aagcattcag 7080 tatattatca aagagcattt tattagaaat caaagagtaa tttgtgataa ctcattgatg 7140 aatatcaaat atcattcttt cggaaatgtt ttaatggcat ttactcatgg agattctatt 7200 aaaatgaaaa atgtaggtaa tgttatagca tttgataata gacaacattt ttctaatgca 7260 agacatgttt atgcttattt tggacattat cacaatgata gagttgtaga tactccattg 7320 tgtagatgtg aatcttttag aaacttagca ccattaaatg cttgggcttc ttcacatggt 7380 tttaggcgtg gtattggaac tataagttct ataactatac ataaagatta tggtgaaata 7440 aatagaaata cttataattt ggatatgata gatggaaaat aattttgtaa ctttaatttt 7500 aaataatggt aaaaagcacg gtgttatatt tgaaaaaaat actattgaaa atgaaacaaa 7560 atgtgagcta tctttaacta ctaaagatac tcaaaatgtt tgggctgatt tattaaaaga 7620 tattaaaaat gactttattg ttaattttgg aagaggtata aaaataacaa cttcaggcaa 7680 aaactctgca aatattaaag ttaaatcaga taaattatat gaaatcaata tgttttataa 7740 tttagaagaa aacaagttta ttattactat aacttattca aaagaaatta acgagtcaat 7800 aacacaatca gtatatgatt gttttctata agatacataa tagtatctta tagatatgtt 7860 ttaataaaat aaatataatt atatactatt attatactct tattatacta cattatactc 7920 atttataaat agataaaaga aataaagtta gaataccctt cacatttttt cagtgattgc 7980 agaattttat cctttagttc tttaaaaatt ctaattataa aaaggagaaa atatggcttt 8040 attaagtcca ggagttcagg taaaggaaat tgacttatct cttacggttt caagtgcttc 8100 atctagtttt ggggcgtttt gtggtatttt tccaaaaggt ccatgtgatg gtgcagtttt 8160 cataaatgat attccaacac ttgaaagtgt atttggaaaa cctacaaatt caaattataa 8220 tgattttttt caagcgtatt gttttttaag aagagcaggt agtttgtatg ttgtaagagc 8280 tattgataaa cttggaaaat ctacaagaaa agattcaggt ttaacaataa atgctgcatt 8340 aaatgaaaaa gcaaaagaaa tagctttaac aagtacaaca ggtttatatg ttggccaaca 8400 aattatgttt ggtgaaaaaa ctgatgctaa tgtttatact atttctagta ttcaagctaa 8460 tactaaaata actttcacac cagaaataca aacaggtgat ggtgctggta attcttcaaa 8520 aatttatatt tgtcacccat caatgaatgc aataggtgaa gttttaaaaa ctggttcaag 8580 taatactata acagatacca aactaaaaga aactcttaca ataattccta ataatgatgt 8640 ttatgaaact ttagagcctt ctattaagtt tagtgatact gaaacaaaat taaaatttat 8700 tgctaaatca gttggttctt ggggaaataa tatcaaagta gcagttgcaa caaaagctga 8760 ttttggagca aagaaaaata ttattagtgg tattccatta gatgataact ttgaatatat 8820 tccagataca gatcaagttg ctgtagttgt attagaaaac aacgaaataa aagaaacata 8880 tatggtttca attaaagaag gctctaaaga ttataataac aaatctaatt atattgaaga 8940 tgtaatcaat agacaatcag cgtatattta ttgtaaaaat aacactacaa tagctgatct 9000 accaaaatct gctttggatt ctggaatcat aacacttaaa tttggtgaag atggagctcc 9060 aacaaaagct gatattatta gtggttacac agataatttt agttcaaaag aagaaataga 9120 tatagatata gtaatagcaa atgaaaaatg taacaaagaa gttgctgatt tttgtgttac 9180 tcgtggtgat gttataggat acataggtgt tccttatgat caagttgtag gatttaaagc 9240 tgaaactgca gttcaaaatc ttttagaata cagagcaaca ggtgagttaa acattgataa 9300 caaatattgt tcatttattg gtaattatgg ttatatatat gacaaatata atgataaaaa 9360 tagatggatt aacttagcag gtgctacagc aggtttaaga gcttttacaa atgaatcaag 9420 acaaccatgg tttgcagcag caggtttaaa tcaaggtcaa tatttagata ttattaagtt 9480 agcgtttaat ccaaataatg ggcaaagaga tcttttgtac aaaagtgcta taaatcctgt 9540 tgttagtttt ccaagtttag gaatttgttt atggggtcaa aaaacttgta ctcaaaaacc 9600 tagtgctttt gatagagtta atgtaagaat gttatttaac tatcttgaaa gaaacatttc 9660 taattcagct agatatattg tattcgagca aaatgatact catacccaaa acatgtttgt 9720 aagtatgtgt actccattgt taacacaagt tcaagctgga cgcggaatag atgactttaa 9780 aatagtttgt gatgatagca ataacacgcc tttggttaaa tcaaacaatc agtttgttgc 9840 ttcattttta attaaaccta catacgcaat agaatatatt acacttaatt tcgttgctgt 9900 aggggctaca atatcttttg atgaggctat aggttcaatt taaaaaataa aggtagctta 9960 aatgctacct tttacccaaa caccttgacc gcaatcaaaa actttataat atccatttaa 10020 aagcatatta tgttgttcat ttagattagg atcaaacttt tctaatttat cttttagctt 10080 atgtttcata aattgtcgtc tgttataagc tattccattc ttaaaataaa aatatccagg 10140 tttagaataa tgactaaaag taaatcctag ttgtttatat atgttaccat tagaatataa 10200 attattagaa tacgatatta tagaatttcc tttgtgttct gtttcaaaat gttttaataa 10260 cttagaagct ccacctataa cattataacc aattttagta catagtctaa gtaactcaaa 10320 atcatatttt ttattaaatc ttgacttacc aaaactcatt aattgtataa gttctttttc 10380 atagtataat ccataacaaa ccttagaacc aatatatcct tgaagatgat tttgttttaa 10440 aaaatctttt tcttcaatat tagaagctat tttaatatca cattttctcg cataaacttt 10500 tgtgttaaca cctattttat tttttattat agaactccat atatttttat tttgtatcca 10560 attactttca aaaatatgta ataattgtat tccaatttct ttacatttaa tacttttatt 10620 aagatggtaa tctttatctt ttactttttc ttcagagtgc cagtaatctc cattgcactc 10680 tatagctaag ttatatttag gcaaataaaa atcaagttct aatttgttta aaagtgttct 10740 atcatttatt atgtaatcta ctccaaaatt atctaataat tttttaattt ctaattcaaa 10800 attagaactt ctaggataac aaataggaca tttcgtttga tttttatgtt ctactactgt 10860 gaaaggtctt tcaaatatat gtccattgtt acatttaaat atatacttag atgtaatatc 10920 ttcattaaca atatctaatc cataatagtt tgcaatgttc tttcttttta tttttttaca 10980 gttttcacat tctctacatc ccctagataa aaaacttgac catcctcttg taaacttata 11040 attacactta ttgcatataa attctctata atcattatta agtttgttat cagttaatgt 11100 aaaaccatat ttactagcta tatatttctt ttctaattct acacagttta gacatttata 11160 acactttcta ttataaaaac tattccaatc tctaataaaa ataatatcac atttattaca 11220 tttaacatga aatactttac taccatcatt ttttattacg cttaaaccaa gtttttttat 11280 gtaatccttt ctataatcta ttttacattt attacaccct acttctttaa taatttcatc 11340 ttttccttgt ttaaatatat gattattttt acattttaaa gtataacttc catttttatc 11400 agaaacatat gataagttca tattttttaa atgtgagttt ataacattcc atctttcaga 11460 ttctacacat tcaggacacg atatattttt acgagtgtta aaagcatacc atgttctatt 11520 aaaaatatga ttacattttt tacattttac agtacactta tctcctttta tagatatagg 11580 aataaatcca agttttctta atgatttata tttatcttca ataacacatt cactacaaat 11640 tatatcttta tcttctgtaa tattaatagg ttttttgtta aaaatatgtc catgtttgca 11700 ttttaatttt atgcttcttt ttgtataaga tataacatca aaaccaatat ttttaataag 11760 ttctattatt ttatctattg tcataattat ctcctgtata attatattta atccaaacac 11820 cctgaccaca atcccatact ttatgatacc catttaatct catattctct gattcagtca 11880 agtttggatc aaatctttct aatttatctt taagtttatg tttcataaat tgttgtcttg 11940 tatgtatcac accattctta aaatagtagt aacctggctc tgagtagtgg ctaaatgtaa 12000 accctaattg tttgtaaatt gatccattag aatatagtct atctgaatag cttattaggc 12060 ttcctttgtt atttttgtga aagcaactaa gtaatttact agcaccacct acaacattca 12120 tacccatttt tgtacatagc ctgatcaatt cccagtcata tttgttagta aatcttggtt 12180 taccaaaact catcaaacaa actagctcat cttggtagta gagtccatag cagatagaac 12240 taccagtaaa tccttggaga tgattttcat ccaaaaattc tttctctttt gttttagata 12300 cttctttcaa aacacatttt ctagccatta tcttgtctga tttacctaat ttattgttta 12360 ttatactaat ccaaatattt ttattttcat tccatgatga ttcaaaaata tggagtaatt 12420 gtattccttt agcctcacat tctaatgtct tacttaaatg gtaattctta gttttgttac 12480 aaggttcaga ataccagtag tctccattac attctatagc taatttatag tctggaatgt 12540 aataatcaag ttgtttttta tctagtattc tgtaagaatt tcgtatagtg ttatcaggta 12600 atatattaat aaattcattt tcaaatttac ttgaataagg attacatata ggacattcta 12660 ctataccttt taatacatta gaaaacattc tttcaaatat atgtccgttt ttacatttta 12720 aaacagtatt atgacctata ttttttgata tagcttctaa attatgtttt ttaagaatat 12780 ctaacttttt atcataatta cactctgaac aatttttatt tttcaaatca taaaatgttt 12840 tatttaatat gtgaccattt ttacatttaa ctttaatata tgttttatta acatttgata 12900 aaactatata tcctttatca tttaaaattt ttattttata atcttctaca catttattac 12960 aagaatgagt acctctttta aaatgattta atgttctctc gaatatatga ccattttcgc 13020 attctactat taaaatatta tttttaccaa aacccaaaaa cttaaaatta tttggtataa 13080 cattttcagc ttcacaatta gcacattttg tagcacctaa ttttaaagac cctagtgttc 13140 tttttatttc atgattattt ttacaagtta cagtgaaaac atttccattt ttatttttta 13200 tttcaaaacc atatttttta aattcttttt tagccacttc taaacgatca ttacatttag 13260 tacatccatt taatttttct aaatcataat aatttgaagt tcttaaatga ttattagaac 13320 atgtaacagt aaacatattt cctttgttgc tgataacatt aaaacctttt gtttcaagaa 13380 ctttagtttt ttctattata tcgcagttgt tacattttgt agaaccattc ataaaattac 13440 ttaactgtct tttaaattgt gttttacatt ttaaacaaac aaataaatta tttgatttat 13500 actcaaaacc taactcatta atatatttta ttttatcatt catttaatta tcctttatat 13560 tattttacat gacatatact ttaattttac ttaataatat aattaattta tttttaagtt 13620 atattatttt ataatcacaa aaatcttaaa taaaaggagt ttagtgtatg aaaaatgatt 13680 ttaatattct aattgcttgt gaagaaagtc aaactatatg caaagagttt agaaagctag 13740 gtttcaatgc ttatagttgt gatattttag aatgtagcgg aggacatcct gaatggcatt 13800 tcaatgatga cgctttaaaa gttattagaa ataaaggtgg agctacacaa agtggagaaa 13860 atgtaaaagt acaaaagtgg gatatgatga tagcacatcc tccttgtact ttcttagcag 13920 ttagtggtgc taagtggtac tatcatcctg atgataaaga tttggcagta gaaaaaagaa 13980 gaccacaccc aaaatttcca aatagagtaa aagatagaga agacggggct aagtttttct 14040 tggatttaat aaactcggat ataaaatata ttgctgttga aaatcctata ggttatatga 14100 atacaaatta tagaaagcct gatcaaacag ttcatcctta tatgtttgga gatgaggctt 14160 caaaagcaac ttgtctttgg ttaaaaggat tacctttatt aaaaccaaca aatattgtag 14220 gaaaaggaga agttattcag ttttcaagtg gaaagaaaat gcaaaaatgg tataatgatg 14280 ctttagttaa aactaaaaca aaagaagaaa gacaaagatt aaggtcaaaa acatttaaag 14340 gtatagctga agctattgca aatcaatggg gcaatttttt aattaataaa gaaaaggaat 14400 ttaaataatg tttaggcaaa acccaacata tcataatatc tatggattta aaaccataga 14460 tttaattgaa tcagctttat tattttctca taataaagtt atgaattata gtataggtaa 14520 aatgttagag tatgctttag aagtagaata tgttgatcaa cctataaaac atttagatat 14580 gatagcatgg catatgaata ggatatattc aaaagatctt aaaaaagaag aaaataatct 14640 tgattatgat attaattttt ttaattatat aagaaagata gaaaatcaaa atgctaacat 14700 atacgcttta gtagttaaca ttttagagtt taattatagt gtaaatgaat caacttatat 14760 aactttaaaa aatgatataa aagtattaaa acaacttttt gtttaaagtt tttttaattt 14820 tattttagta tgatacacaa aatttataag gaggaaattt atatggaaaa tataaaagta 14880 gaattgttgc attacacgcc aattgaaata gctatagatg ctattagaac ttgttgggat 14940 agtggctcaa aaaaagatag ttgttataaa gatgaagagt ttatagtagg tgatgctgat 15000 tgcaggctgg ttgataatat tgtaaatcat cataaacatc atagcactgt agaacacttg 15060 tttttcaact tttttataaa aggtatatct cgttctgttt tacagcaact ttgtagacat 15120 aggatagcaa gttatagtgt tgaaagtaca agatacactc taaaaaaaca cttaaaaaat 15180 gaagaagagt ttaaagaaaa tgattttact agagcttcta aatatgttgt tttaggaatt 15240 gataaggaag taaacttaga agttgttaaa acactagaaa atgtgagaaa attatgtatt 15300 gctaataaaa gtaatgacac aataaaatat gcattacctg aagcatttag aactaattta 15360 tattggacaa taaacgctag atctttaaga aactttttag agttaagaac atctaaacac 15420 gcattacttg aaataaaaat tttagcaact aaaatttatg aatcactacc tgatttatat 15480 aaaaagttat tgtttaaaga tgttgttaaa gagttaaatg taatgtggac tgaagataat 15540 aaaaatgtga gtgaaaataa agaaacaaaa aaagaagtag aaaaagttaa gcctatttca 15600 aaacaaaata caaaaaaatc ttctaaaaca aatgtgaaaa aagaaaaatt attaaaaaaa 15660 ttaaaagaaa ttatcaacga tgatgaaaaa gttgtagaag aagctattaa aaaagttaaa 15720 tctgtttcaa aacaaaatac aaaaaactct tctaaagtaa atacaaaaaa agttaaagtt 15780 gatactaaag cttcttctaa aacaaatatc acaaaaaaag aagttgataa caaaatgaaa 15840 tataagctta gtgatcttgt taaatcaaaa ttagaaaggg attctgtatg taagtttttc 15900 aaaaggaact tttctgatgt ttataataac caaagaaatc ttattaataa ttcaaaagca 15960 tttactcttg aagattactt ttttatgata aatgaaagtt taaaattaaa aaacaaagac 16020 ggattcaaat ataaatctgt aattttaaac cttaaaaaag agcttaataa gttaaaatct 16080 aaaaaatcaa aataatctta ttttataaaa cactcataaa catagtttcc ttgcgtttta 16140 aaaggaaact atttcttaca tatataaaca tactaataat ttactttttt taattttaaa 16200 gcattataaa tgcgttaaaa ctaatattga ttaaaaacaa ataaaatttt atttttaatt 16260 aatattttta tagatataat tagttaaaac ttttaaagga aattatatgt tattaaaagt 16320 taaatcaaaa gacttaaaat tattagttga caaactaagc attttttcta cagaaaaaaa 16380 tccttgtgtt tgttttgaag caaagcaaaa tagtttaaaa atttcattgc atcaattaac 16440 aaatcagatg gaaaatttta tagattttat tttagaagca gaagttttag aagaaggtcg 16500 tgctgttgtt gaacttacat ctctaaaaat agtgtttaaa aataaaacga atgagttttt 16560 agaaataagt ttcaagtatg gtgatgataa aactatcatc aaggataaag taaattataa 16620 attaaaatct tataacactt gtgaaatatt tgatgatttg tttaaacaca aaatactaga 16680 taaaacattt ttagatataa aaacatttac agaaaaatta agtaatgtta aatgtttctg 16740 tgataaaaat aatatgaagt ataatttaaa tggggtattt gttgatataa aacctaataa 16800 aattaatttt gttgcaactg attcaagagc actagcaata gaagaacttg aaagtaattt 16860 tgaatataac aatgaaaaag gttttatagt acataataaa agtatagaat gtttagagtt 16920 tttagaaaaa acatttaaag atgaaaatat aaaaatatca tttaatgata aaagaatgaa 16980 tgttttttgt gacaagttta attatacatt tgattttata gatgatgttt atcctaatta 17040 tgaaaaaatt atttttaaaa cagataatga aacaaaaaaa tctgaattaa attcaaaaga 17100 acttttagat attctaagtt tatttaaaat aggatatgat aaggtaaatt tttgttttaa 17160 ggataacgaa cttaaaatat caaatgaaat ttttgatgat atagaaatag aaaaagttat 17220 tgaagttaaa tcagaaaata attttacatt tataacaaag ctttcaagta taataaaatc 17280 catttcattt atagaagact ttgaaattta tacacaagat tacagaagat atattttaaa 17340 atctaaaaac agaaatagat taattatcat tgcatcattt aaataataaa ttaaaagata 17400 atcatttttg gttatctttt tttactcgtt aaaacactat aactttttta taaaattcaa 17460 acaccgcact taagaaagaa actaaaattt aaaaatcaaa aaaaaaaaaa aaaaaaaaaa 17520 aaaaaaaaaa aaaaaaaaaa aaataaaata tattatataa gtaagaaaaa aaaaaatttt 17580 tttaaaaatt tttttgtaaa attttaaaat aaaaataaaa taaaaattta gtattgaatt 17640 aaaaatattt tttattaaca cgcataaaaa ataatatctt aaatattaaa ctacatttac 17700 taactttatt tcttagatta tattttgtta tatcattaat tattttaatt caatactaaa 17760 tttttatttt atttttattt taaaatttta caaaaaaatt tttaaaaaaa tttttttttt 17820 cttacttata taatatattt tatttttttt tttttttttt tttttttttt tttttttttt 17880 tttttttttt tttttttttt tttttgattt ttaaatttta gtttctttct taagtgcgga 17940 tgatgaattt taacttttgt ttgtgtaaat ataaataaaa ataaaaaagg tttattttgg 18000 atatacaaaa aataaaagat gataaaatag agtatttaaa taatttatta cctaaaaacg 18060 aaaatggata ttatcttgat attaacaata aaaaagtaag ttatgacaac aatccattat 18120 tagcaaacct ttatacaaaa cttcctttaa cagaagaaca tattttagaa attcaaaaat 18180 gtagttcaga tataatttat tttattgaaa actatgttaa gattagaagt cttgatgagg 18240 gtttagtcta tcctgattta agagattacc aaaaagattt gataaaccaa tattatgaaa 18300 acagatttaa tgttgtatta gcaggacgac aaagcggaaa atctattaca acaatattgt 18360 ttatactatg gaaactatgt ttttgccctg atacaatagt aggaatttgt gctaataaat 18420 tttctatggc tgctgaaaat ctacaaagat taatggaaat gtattcggat ttgcctatat 18480 ggttaaaacc atctgtaaaa gtttttaata aagaatcttt tgcaaatgaa ataggatgta 18540 aagcatatat tagtgcaact acttctgatg cttttagggg tcttagtatt aatttgattt 18600 ttattgatga atgtgtttca ggagatacaa aaataacagt tagaaataaa aaaacaggta 18660 ttatagaaga attaacaatg gaagaattat ataatagaat aggttaatat tattttaaga 18720 atatttatta tatcattata aatataacat atacataaaa aaaaggatta aaaatgtcta 18780 ctctatatgg aaattttgtt gttcaatcta taaaggatag aattgagtat gttaaaaata 18840 agtttggatg ggaattccct tgttctgaaa tagaagatta ttttattgag tttataaaag 18900 aaataggagt tgactcagaa tctacacctt ctgaagtagt agataacgct atagttaatg 18960 gatcttatgg tatatatagc gatttttatg aaacagaaga agaagctatt aaagcatatg 19020 aagatggaga tattctttat gctgtagaat ctgatgatgg aaacttatat gttgttcaat 19080 atttttaaaa aaggattaaa atgaaaagtg tttattcaaa atatttatgt gaggggtctg 19140 agtatgaggc ctataaagaa tttagagatg tagaaacagc tggttatgag atggataaat 19200 tgttatcaag tattgagttt cttatgttta gaattaaaaa aatatttgaa aagaataata 19260 ttgatataac agaacctgtt ataaaagatg atgaagttca atttaaactt aaaaactata 19320 ctgatgaaga aaatgaaaaa gcagaaagaa tattatttga tatgagagat atagcttggg 19380 gtccattaag tggagatttt aatgatatga caaaaggtta tggtgtatct ttggatttag 19440 atgaggatta atatttaatt aaatgccaaa ttatttttct agtagtaaac caggttctaa 19500 tcaatctaat atagtagata gttctaaacc tggttttgtg tcttcttatc agaaaaaaac 19560 aaaagaagaa ccacaaaata taagtgagca atctaaaaat atagaatctg gtaaaaagat 19620 aatcaaagat actgttgatg atgctttaaa agaaaaaact acaaaagagc aggaaaaagc 19680 tgctcttgat ttagtaaaac aacttatgaa aaaaaataca agaaatttaa aagccgatga 19740 ttttagattt acaaatatga tttttatgag atatgatgct aaatacaaag ataaagttta 19800 tgataaaaca cctttgatct tagtattaag aacttcaaga agttatgttt taggtttaaa 19860 cttacattgg actcctgtac cacttcgtat agcattaata aaagtattat ttaaaattaa 19920 taaagctgta attaaaaaga ataaacaatt aaaaataaca tatgaaatgg ttaaaccact 19980 tttaacttca ctgcatttag gacctgtaat aaggttatat attaaaaaaa gaatagctag 20040 aagaggttta ataatacctc aagatttatg gcttgtagct gctagactta gagcagaaac 20100 atttagcggt ggttattcag ctaataaatt atatgcaaat gcaatagcag aatataaaaa 20160 atcaaaaact aaaaacattc gtaaaaataa aagaatattt taacaaaact taatatataa 20220 tatagcatta aattattaag agaatattat gacaacagat gaaaaaataa gttttattaa 20280 aagtttagga tatgaaataa tttctaatag tttaggaaat aatttacaag taagatgtaa 20340 aaatggacat atttttaaaa ggtcgtttgc tgattttaaa aaaggttcta aaaaatgtct 20400 tgaatgttta aagtatgaaa aaataaagtt tataacagat ttaaactatg aaattatttc 20460 agaaaatata ggagatcatt tagaagttaa atgcaaaaaa ggtcatatat ttaaaagacc 20520 ttttactaat ttcaaaaaag gtgctgtaaa atgtcctgaa tgtttaaaag aaacaaaaac 20580 aaacttatta catgatttag gatatgagat aatttcagaa gacttgggtc ataacactaa 20640 agtgagatgt aaaaacggac acatatttaa aagaaatttc aataatttta aaacaggtta 20700 tataaattgc cctgtatgct caatagaaaa taagaataat attttaaatt ctatgggtta 20760 taaaattata tccgataatt tatctgattg tttagaagtt aaatgttcta aaggtcacat 20820 ttttaaaaga agttttagaa catttttaaa aggtgctgta aaatgtccaa aatgtataga 20880 aaatgaaaag aaaagaatat taaatgattt agggtataag tttttgtatg atagttatgt 20940 tcaatgtaaa aatggtcata tctttgaaag atctattgca ttatttaaat caggttgtgt 21000 aggttgtgtt caatgtgaaa aagaatataa aactaaactt tttgatgatt taggatatga 21060 aattgtttca gaaagtttag gagataattt agaattaaaa tgtaaaaatg gacatatctt 21120 taaaagaaca tttagcaatt ttaaaaaagg tgcgttttta tgtcctgaat gttatccttc 21180 aaaaagttct tttgaaaagg aaatatctaa actattagat agctatatag aaaatgatta 21240 ttctgtttta ggaaataaag aacttgattt ttatatacct gaacataagt tagctataga 21300 atgtaatgga gattattggc attcagaaag caatggaaaa gataaaaact atcatttatc 21360 aaaaactaat aaatgtttag aaaaaggaat acagctttta catatttttg aatcatcttg 21420 gttagagaaa aaagatattt ggaaatctat tattaataat aaattaaaca ggtcaaaaag 21480 aatatttgct agaaaatgta ttttaaaaga agtttttaaa gctgaagaaa aagagttttt 21540 agaagaaaat catttacaag ggtatgtttc ttctaaaatt tgttatggtt tatattataa 21600 taacgaacta ctttctttaa tgtcttttgg aaaacctaga tttgcaaata agtacgattg 21660 ggaactaata agactatgta caaagaaaaa tataaatgtt ataggtggag caagtaagct 21720 attaaaacat tttcataaaa ataataaagg ttctttaata agttattcag atatgcttta 21780 ctctgatgga ttaatttata aaaaactagg atttaccttt agccattatt ctaaaccagg 21840 ttatttttat tttaaaggaa ataataagta ctcaagacaa caatttatga aacataaact 21900 aaaagataaa ctagaaaaat ttgatccaac acttacagaa tatgaaaata tgattttaaa 21960 tggttttcat agagtttggg actgtggtca aggtgtttgg attaaataaa gtttatttta 22020 agaataaata ttgtataatt ttattatatc aaaaaaagat atgggtatta agctaattgt 22080 tgattatttt tttttttaat cttatttttt tttcagctat tttcggctaa ttattttaaa 22140 ggatttatta tgagtaacga atttgacatt ctaactggtt tttcaggtgc agatttaatg 22200 aaaaagatgc ctcaaagctc tgttcaaaaa aactacaatg acactagatt ttggaaactt 22260 gcaaaaaata aagaaggtag tggtgctgcg gttattagat tagtaacaga taaaaataaa 22320 gtgccatttg ttcaactata tcactatgga tctaaaaaaa caataggtga taaaacattt 22380 tggctaattg ctaatagccc aagcagtata ggtttgcctt gtcctattca agaagaatat 22440 tttgatgttt taaatagtgg agatgaaaaa acagctaaag atttttattc aagaaaagta 22500 aaatattata ctaatattat ggttattaaa gaccctgcta atccacaaaa tgagggtaaa 22560 atatttttat ttgaatttgg aaacaagctt aaagaaaagt ttatgtcatg gatgaaccct 22620 gatgaaacac aaagatcttt aggtagacaa gaaaaagaat tatacaatcc tattaatggt 22680 tataatatag aattatctat aaaaaaagat ccttctagtg gtttttataa ctatgatagt 22740 acaactttag atatatctcc tacaaaactt ggaaatctaa aagataacaa ggatattgta 22800 gatgttattg taaacaaaac ttatgattta agtgaattta caagtcctga ttattttgaa 22860 acatatgatg agttaaaagc aaaattagaa agatttaaaa atccatttaa ttctaataga 22920 cagtcaagtg ttccatctgc tgtagaaaaa aatactaaag atgatgattc ttttgttgaa 22980 gtttctccaa aagaagtaga acaacctaaa caaactacaa aaaaagaaaa agttaaagta 23040 gaagctaaat cagatgatga agattggtta aatgatataa tggattaaaa taataaatgc 23100 tatttccaaa aaaaaatgga aatagcatat aaaaaggatt tttatggatg taacacactc 23160 acaatatgaa gtaatgacaa gtgcttataa aaaagatttt attccaagta ctaatgaact 23220 taacttacta aactctttca tgttatgtag atggatgagt aataatatag attcagttga 23280 atttgcaaac tttataaaca ataacacaga tattcctata aatgcacagt attggggtgc 23340 aaggtcaata atgaataaag tatcatatat aagcagacca caaaaagatg ataaattaaa 23400 tgagtatgaa gaatgcatta gaagatatta taatgttagt ttcgatgttg ctaagcaata 23460 ttgtaaaata ctacctttag aaaaaaaaga agaaatttta aatatgttta aaggagggat 23520 gataaaatga aaagagatga atccattata aagtcattta aaagggaaat aaatctacag 23580 acaagatttg ttaaaaataa aacaaaatat acacgaaaag aaaaacataa gaaagggagt 23640 gctataaatg gttctaattg attttatgca cttagctttt aaaagtttat atgtagcagt 23700 aggaaaagaa gcatatagta aaaaacaaat aagctttaaa aattatcatg gaatgtttgt 23760 acatttaatg tttaattatt taaaactaat tcaaacagaa tatgcaaaat attatggaaa 23820 tgaaatagtt ttagctcttg aatgttctaa ctcgtggaga aagtcttatt atcctgaata 23880 taaaaataat agaaaattat ctgaaacctt tgattggaaa aatgaaatat ttcctgcaat 23940 taatgaaata attgatgtta ttaaaaaaac attaccttat aaagttttaa gagtaaaagg 24000 tgctgaagga gatgatgtta tagcagtctt atcaaattat tctgcaagtc ctgttttagt 24060 agtatcagag gataaagatt ttattcaatt attattaaac aaaaatatta cattgtttaa 24120 acctataaaa aaagagtttt ttagaaatgt tgataaatct gaaattgaaa aaactttaaa 24180 catacatata ttaataggag ataaagttga taatatatct tctgtaatgg aggctactaa 24240 ttttacacct gattttataa agtttttaga atctaatgga atttttgaaa cagatgtaaa 24300 caaatttaat tctttagata tatcaaaaac actatatgat ctttattcaa gtaaaaatga 24360 aaaatctcca ttcaaagcac cacattttgg agaagtagga gctaaaaagt ttttagaaaa 24420 cttaaatgaa aaccttgaaa aaaataaagt agtatataac aattatataa gaaataaaac 24480 tttaattgat tttagagaga tacctgaaaa cattaaaaat gatattatag aagcttataa 24540 aaacgaaaaa cctacaatag acttaaatca tttacttaaa tttttcttaa agtataattg 24600 taaaaaacat gctgatagca tagctttatt taacagtggt aatgtagaat ctatatttga 24660 tgattggata tgatcttata aatataattg taattttata tttataggat tgtacaatga 24720 tagaaccaaa aagagagcct acacaagact tttttgtatg tttattaaaa gaacctagat 24780 gggttagtat tgatgattta tatgctatat tattaatacc aggagttaca tatccagcag 24840 aaatagctat gatgcatcct gattttttcg gtggtgatga tgttgtattt aaacctgaac 24900 ctccaattga tccagataat cctgatttat ctaactatta tacaaaacca gaaacaaata 24960 atttattggg tcagaaagca gataaaattg tattaaataa ttattatgat aaatcagaga 25020 ttgatcataa atttgaaaac ataactattg atgatattaa ttatgcgaag ttaggtgagg 25080 aaaatacttt tattcaagaa caaaacataa aacaagtaaa tataagtgat gaacctacac 25140 tagatactca tgtaattact ttaaaatatt ttaaagataa ttctagtggt ggtatttctc 25200 caggtgatta tgtaaccaag actgaattta caagtggtat taataacaaa gctgataaaa 25260 ttcatacaca tgttgtagct gatataacag atttaaattt agatagactt gctacaaaag 25320 aagaaacata tactaaacaa gaaatagata ataaaataga cgcaatagta ccacctgaaa 25380 ttgacttaac tcattatgca aagaaagatg cagctaatat ttttacaaaa gctaatactt 25440 ttacagaagc accttctgta aaagtagatg caacactaga taatcatgtt attagaaaaa 25500 aacaatttga caataacata aaagaaataa atgataaagt taaatctgtt gttggtgatt 25560 taaattcatt aaacaatgaa gtttctaaag ataatttagt taatgctata aatagtgtgg 25620 atgataagtt caaaacaaca gctaaaacta atgaatcaaa tacatttaca ggggatcaaa 25680 cttatttaaa taatatttta ctagaatctg ttccttctga aagaaatcat gcagttaatt 25740 tgggatatat tttagataat cctggaggta taaaactccc tgatcataca gcacttacac 25800 agagttctgt tacagaaata acttttggat atgcaaatcc agtagcatac tctgcacaac 25860 aattaaaaaa tgtattccta aaagatatat taggtaatga atataaagct attatggcag 25920 ataaaacatc atttacagca aatccttcaa aagaaatggt tgttatactt tctagaactg 25980 attatacaaa aaatatagat gttaagtttg acataactaa aacagttgat gagcttaaac 26040 aatataagct taaagaagga gaagttagag ttatactatc ttatgatgtt atatctgttt 26100 attctagtgg atatggttat ggagctatgt ttgctagaaa cgctaataaa aaagacggag 26160 atttaatata tgattattat tttggaagtc aaaatgatat aacaaataat agaaaagtat 26220 ctataaaaat agatgcacta ggaagtaaca ctccggatat tgtaagtata tctatgacca 26280 caaatggttc tgaaaaatta acagtgaaaa cagatacact agatcctgtg gaaaatacat 26340 acgaatctgc agatatgact tatattcata cccctgtcag caaaattgta ggagatgttc 26400 tttatagtaa tatatctcaa acaataaaat caatacattt attagaaaat aatatatgtt 26460 ctttaaagcc tgcagatatg gagttacaac ttgtaagact taaagaattt aaacaaacaa 26520 taaatgatat gttgcaatct atgtttgatg agagtcctgt aactctaaaa aatggagatt 26580 acataggtgt ttcatttagt ggcagtgcaa gctatggaac aggatattgt gggtatgtta 26640 atataaaaga tactataaga gatattacat ataaagctta taaagtatct tcaaatgctt 26700 ttgatacatc tagtggaact aaagttattg cagttctcac ttctgatagc agtaaaacaa 26760 atgtaactta ttctgatagc atatcaacat tagaatctta tgaagtagca gaaaatgaga 26820 tattattaga aatatcattt tcaactgcta agcaatattc tgctaaatac gggtatggag 26880 ctatgttaga gtattggggt tctttatctg atttatgtta tgattattac atgggttcaa 26940 atctagatat ggattgtcca tttaaaataa cactactaaa actaggaagt tctgttaaag 27000 cagatactat acaaataggt gctcctactt ttgcaggttc attagtaatg cacttaagaa 27060 aaaattcaaa cgatgttatt gattttcttg tatctacagg tgtgaaagta acaggaagag 27120 atggtactga aagcggatca gtatataatt tagtagataa agctttaaaa cctttaaaag 27180 ttctgacatc tgaagcacat caatctataa atggtataac taatttcaat aacaaagctt 27240 atctaaatat agatagtaat aaaattacag ataataagca gattataaat aaagaatatc 27300 ttgatggaag tatagagact acaactaaag atattataaa tgggactcct ataatacctt 27360 ttacaaatat tgaaggcaag aatactaaaa atataagact taaaatatat gcaaaaactg 27420 atagctctag ttactctact ggagatacag ttgtagtaag taatcttaaa gttaagctta 27480 aaggagatac tgagtttctt aaacctgttg gagttgaggt tactgacaga agtaatcaaa 27540 aagtaggatt aaacttaaca ggagatgaca ctgtatataa ggatgatagt gctattacag 27600 caacaaaacc ttcaggattt aatatctcaa gtattgattt atctagtggt agtaatgctg 27660 tagctacagt aaaaacaaat ggtgcatacg attatagtgg aacatatgag atttgtaatc 27720 ctttcagaga gtataataaa aaatattgcg tatttttaag ttctgatgga ttaaaaaaat 27780 ccttactatc aagtaatttt agaaagctct aaagaagtag aaaatataca attacaatta 27840 tatggaacaa gtgctaccaa tcctttatta tattctaaag aatgtataat agaaatatac 27900 actgatgata cacttataag gtcgtttaat ataaaaaata agaacgataa tacaaataaa 27960 cctgttaata ttaaactaga ttttaaagat ggaatttctt taattcctat agaagaggct 28020 gtatctaatt taaaaaacgt tatagataat aactcatctg ttttatctgg aaatggaaaa 28080 ccttcatttt cactaaaccc taataaaata ggctctctat actctgatat aactaataaa 28140 gctgtgtata tgtgtataga caattctttt ggtgctaata aatgggtgaa tatagtaaca 28200 ggggatgaaa ttaaaccaag ccttagaaaa atagaaatca cttgtaatgt aaactttaga 28260 agtggccaat acggtggttg tatgagcggt gttaaaatag gatttgataa cgggtatgct 28320 tctacaaaac aaatagttaa agggttaaat agcggtcaaa tattactatc tctagatggg 28380 ttgggtaatc tttctggata ttctgaagtt agttctttaa ctcctagcgg tcaagatata 28440 aaagttgatg tggatactac tgggatatat ggtgaccctg catatcattg cgttactaat 28500 atatttaaag agtatcttgg taatcctgat caatgctcgc tatggtatga tgctagtgtt 28560 aaacaactta aaataacttt actgtctgaa aagattccta ccaaaatatt atatgtagga 28620 aacggatatt atgggcaaac atctgtttct gatgtaaaag ctatatggta ttatgtaaat 28680 gctagtggag acaaaataga aggtaatgta gataataatc taaatgtaag tgataatgtt 28740 tctgaaacaa acgatagttc ttatatatat gcgttcaata taaattagat atgtaagact 28800 gtattaatga tagagccaac taaagacttt ttaaaagcta ttgtttggaa acatcattaa 28860 tactttcatt tatataagta aaccttaaga atttctatta tatactatca taaattataa 28920 ggaagtatta tgatagtatg taattataat gtagtgccaa ttataataag tttatataga 28980 aataatttta acacgcaaga gattaaaata tgtggttata atcaacttaa tgaatatatt 29040 aaagatggtt caaataagtt tgaaataata ggatttaata ctgattctat tgatttacca 29100 aagaatgtag taaatcttga aataaatttt aaagacatac caaaatactt acaaaaccca 29160 ttaaaatcat attatgaatg ggataaaaat aatcaaatgg attttttatt tggatattat 29220 ttagatatgt attttaaaaa atacaaaata ggatcactta tagacttact taaaaacaat 29280 aacgaagaag atatttataa tattgttaaa aataattttt tacaaatgga acacaattta 29340 aataatggtg taataagaga aaaaattatt aatgatgtat atattatgaa aggtaattat 29400 aattcctttg tatataaaat ggtaacatca cagcataaga catatatact agatgacgat 29460 ttaggtaagt taataatatt ttcaggtgat attaatatga tttatgatag gatatctcac 29520 ttaaaaatta atattattaa aaccgaaaat tgtattgttt taaataatgt tgataataaa 29580 aaacaaacag taaaattgat gttaggatta tcatgattag tggattaata ttaaaaaatt 29640 taattaaaga tgaagtttat tttgacaaag tttattcaat actaaaagat gaacatttta 29700 taggtgtaga tgctgatatt tataaaacaa ttcaaaagct tgttaaagaa tacaataaga 29760 agcctactgc aaaagaaata gctttaaaat taaaagataa ttttaaagat gaacaacaag 29820 aaaattgtat taatagattt aaagatatca tgctagatga tcaaaaaatt tctacagagt 29880 ttcttaataa tgaaacatca gagtttataa aacaagctga aatgagatct tgtattatac 29940 aaggtgcaaa acttatacaa gagaaaaaag atataggtaa aatatatgaa agattagggc 30000 aagcaatatc ttttagtatg gatacagata taggtatgaa agatattgat gcagaagaaa 30060 gagataggtt aagaagagaa aagaaaatag gtatctctac aggagttgca acattagatg 30120 aagtattagc aggtggctat atgcctagca cacttaattt tatttgttca gtaactcatg 30180 gtggtaagtc tatgttttta tcacatttct gtgctaatgc tatgataaaa ggttataatt 30240 gtctttacat aacattagaa atgccatcta taaaaatttg ggatagaatt gaaagcaata 30300 tttttagtat tgatattagt gagttaagaa attataatgt ttcagaagga tacaaaagat 30360 tgcctgattt aggaagatgt gttgtaaaag aatatggtgc aggaagtttt gataccttac 30420 aattaaaatc tttagttcaa aaagtagaat ctagtttaga aattaattta gattgcataa 30480 taatagacta tttagcactt atggcttcat atgctttaca acctagcgta ggtttatatt 30540 cttattataa gaagatcgca gaagaattac acgcatatgc taaagaaagc aaaaaatgtg 30600 ttttaagtgc agctcaactt aatagaagtg cttataataa ttcaagtgca gatacaagta 30660 caatttcaga gtctttaggt atagcacaaa cagctgatac tattgcaatg ttacatagat 30720 ctccagaatt agatgaatta ggacaagcaa taatatcttt tacaaagaat agaaatagtg 30780 gtaacttatc taaaaaatac ataggaataa actttaaaca atcaagattt tttgatatag 30840 accaacctga ttaatgaaaa cttaagacat ataatgttat aatagataaa atttatatag 30900 aaaggaataa aatgctttta aatagtaaaa caatttcatt aatagcttca ttacaactta 30960 taaatgaatc tattattttg tcttctaaat taacaggtat aaaagataat gctaatagta 31020 ttattgcatt tattgatatg gaaaaattag aaaacaaacc atttgaaaaa gatttcggca 31080 ttcttaaagt aaaagaatta atggatttaa ttaaaatagt tggagatgat tcaaatattg 31140 aaatagatga acaaggtgtt ctacacatat ttaaagatgg aattcattgt aaatatttaa 31200 caactagcgt agatgtttta gaagatacct gtggtgctaa acctacaata cttgatgttg 31260 ttaataaagc agaattagta acttcttttg aattgaatgt aacaacttct gataaaatga 31320 aaaaagctgc aactttatta ggatttgatg atatgatttt aaatatagat aaagataata 31380 atattttaac attatctaca tgtgaacaag gaactaatgg taatgagttt tcattaaact 31440 taacacctga ttttgtaaat atgagtacaa atatttttat tagtataaaa aatttaaaaa 31500 gaataccaac tgctgattat aatgtttgtg tttataaaca ttttgctaaa aacgataagt 31560 ttattttaaa attagttcca aaaaacaacg atgcacttac aattctaatt ccacctaaag 31620 taattttata aaaaaactaa tgagtaaaaa aaattactca ttagaatata ataaataatt 31680 taaacttcaa ataattatac aaatactatt ataataaaaa ttttacaaaa aatactaaaa 31740 acttaataca aataataaaa atattaaaaa ataaaataaa agttttaaca caaatatttt 31800 ttctaaaaaa ttaaaataaa aattttacaa aaaaattttt aaaaaaaatt tttttcttac 31860 ttatataata tattttattt tatttttttt tttttttttt tttttttttt tttttttttt 31920 tttttttttt tttttttttt tttttttttt tttttgattt ttaaatttta aattttagtt 31980 tctttcttaa gtgcggatga ttaactttaa cttttgtttg tgtagatata aataaaaata 32040 aaaaaaaggt ttattttgat acagtataaa gatttaaatc caaacgatat tgaaaaagat 32100 ataattaatg ttgacacttt ttatgtatca ttaaaaaata ttgttactac aatgatggga 32160 gatatatcag ggtttcctga gttttcaaat aacgcacaat tactttttga tcagtatagt 32220 tcaataacaa ttgacgctta taaaacatca ttgaaaacat ctattcaaaa atttgattat 32280 agaattatag ttgatagtat aaatatcaca aaaggaaata ctgataatag tgtgtatgtt 32340 gaaataaatt atagagtaaa aaatacaact atatcagaat cagttagtat aaaggttgga 32400 taatggcgga tatgataatt ccatatagtt atgatgatat taaaaatgaa gttataaaaa 32460 aattaaaaga aagagggtat aatgctgatg tacaaagttc taatgcaagt ttattagctg 32520 atatcttatc ttacttagca tatggtataa acatcaacac ttcatttcaa gcaggagaaa 32580 tgttattatc aactgctgaa tatagaaaaa atattttaat gggtgctaga caattaggtt 32640 atgaatcttc aagaaaggtt tcttatacct attctttaga aataaagcct ttaaaagata 32700 gtgaaaaaga tgacacaaat aaagataaaa gattatattc aatacctaaa tacactaaat 32760 ttactagcgg ttcaaatact tattattaca tgggtaatga tatagagttc gaagtgtcaa 32820 ataatgatat aacaaatggt aattatccta caactataat agatgttaaa gaaggaacat 32880 tatataaatg gaatgataat caaacttctc aagtgtttac attagacgct attcaagtag 32940 atggtattat aaagtcatct aataaaatag ctttatataa acaaaatata gaagaaaatg 33000 gattagaaat atttgttact tatatagatt caaatggaaa tagtaaagta gatgagtatt 33060 gggaaaaatc agatcaattt atgatagatg ctgatacaga tacaaataaa aaatattttg 33120 ttttaaataa tattgattat ggcggaatag atgtttattt taaactttca ggtataggaa 33180 ctaatttatt gccaggaagt gttataaaag ttacttactt agaatctaaa ggtagtggtg 33240 gtgttagtgg tgattcattt tatttttcag aaaacacata tccatttaat cttatggaaa 33300 tagatagttt tagtttaaaa gttattggaa ctgatgaaga aacaaatcaa tctattaaag 33360 aaaatgcacc tatttttcat aactctgcaa atagagctgt aacagctaga gattacacag 33420 caatttgtaa taggtataca aacatttatc aatcacaagt ttggggtgga gatgaagaac 33480 aagttgtgca attaggtcat atttggtttt catttattcc tgaatatcgt aatcaaactt 33540 ttaactttga tgaaacagct caaacatatt atttagcaga taaaaatgat tcatactatt 33600 taaaagaaag tgagataaga tctactactt tagatgctaa tggaaacatt ataaacaaag 33660 gtatatttga tgaattagat tcgtataaaa taatgactat ggaattacat aatagatatc 33720 ctatctacat ggattttgat tatgaaataa gaatagttaa acaaaatgta gttatatcta 33780 aacaagaaat ccaagataag ttatttgaaa ttttaaagaa ttattttaaa acaagtatag 33840 agttttttga aacttcttac tttcattcta atgttataaa aagacttgat acagaattat 33900 acgatgcttc tggtttacaa gtaacagtta atatgaatat accattatat attagaaaca 33960 aagaacccaa taaagatgta atatacattt atttggctat accttttgag caaataataa 34020 caaaaacaga agatgggcaa aatcaattac atcctgattt attaccacaa ctaagttctg 34080 atgattttgg cggagatgta gaagtagatt ttaatcatcc tgttggtggt tttacacttg 34140 taggaaattc agatgctata ataggaaact ttgtaatagg agatggaagt tctgcaatat 34200 ttgatggaga aaaccttgta acaactgatg gaattattgt aagaagtaca agcataagtt 34260 ttaatataat agttaatgga acagttatag gcaaatataa tatagtatat aatgatagaa 34320 gaagatttat agttatagaa ataacagatc ctgttttttt aagtgctctt gataatatta 34380 ctccaaagta tttaaaaata aaatattcag ctgataattt atctttttat aagaatacaa 34440 tacctagact atcatctgtt aaatttgtaa gcgaaagtga tgtgctatga taaatcgtgt 34500 agacttacct aatatttaca atgaaaacac tttaaataaa gatagtgtag aagttttata 34560 tgaagtatta gataaggtaa atccttatgg tttagatatt tataatgtat ttaaaaagcc 34620 taatgataat attactgaaa acataataaa aatatatgct gaagctttat attatggtat 34680 acaaaaagca ttaacaaatc ctgttataat tcaaaaaatg caggaaaaaa taggaacttc 34740 aagcaactat aaaccttttg atattattag aaagttttat aaaaagttaa taacagatta 34800 ttttattaac ttcacaaatt ttaaagagaa aaaaggtctt gatgtagcaa tagaatacgc 34860 atataatatt atgtttatgt caggaattca gcctggttta gatgtaaatg gttctaatgg 34920 gtttaactta aaatttggta ctgaagaaaa tcctaacgaa cctttttata ttagagttga 34980 aggtgtttta gaccctatac tttatgaagg tagtgtaaaa tcaatagctc atccagtagg 35040 ttttggatac agctatgtta taaacttagt attagaattt atagaatatg ttgatgattg 35100 gattacttat aatataagta ttttggaaat tgtatctaca aattatgtta aaccttttga 35160 tccgacttta gttgaagata tatatacttc aaaaaatata caagatcaag aaagaatagt 35220 tataacattt aatgatggaa aacaattaat aaaagatttt aatggattta taacctataa 35280 aaatgctgat ggaagtatta ttgaaacttg ggataatact tatattttaa gattagaata 35340 tgatatagat ttaaaattta tattagatga tatttttgat aactctgaat acaatacaat 35400 attatatgat tgtgtatgga atagatttaa tagttttgac acacctatta taggtcaagc 35460 tattgttaat aagtttagag tagctgataa atattactca tctataataa taggtaatgt 35520 tgatgataat acggtttata cattacctga tgatcctact caatacacac ctgaaacaat 35580 gcctgatttt ttaacaaatg caataaacag aggattattt gaacatatac acgatgatat 35640 gtcaacttat acaaatgatg agtttttaga taatattata gaaactacac aacctagcgt 35700 aataggaaat aatttaatag taggttcttt tattgtaggg tcagaagaaa gcggtatttt 35760 attaggtgat aagtttgaaa tagaaagaga agttaaaggt attgaatatt cagaaaatgt 35820 tactgaaacc ttaactacaa gtttatatgt aacacctgag cttctttttg atgaaacagt 35880 agttaatgaa acccttaaaa taactgtagg agattttaaa gttggggata taacagtagg 35940 tgcaaaaatt cttaataatg gtattttatt agatgatgct tttaatataa atattgtaaa 36000 aacaaggaat gataatggta gaaacagtta gccaaccaaa aggacatttt aaaattgaat 36060 tgttagataa agatagaaat gttatagaaa cttttgaaaa acataactta gttgtaaatg 36120 ggtcaagacc tgtgttagct tctcatatgg ctggtagaag tgctgtacct gtaaacaagt 36180 tagtattagg tacaaagggt cacataggta ataatttaat gatgcctaaa acagctaatg 36240 aaggatttac agctgctaga actcaattat ttgctgaaga agaaggtgct tttgtttatc 36300 atgttaattt tacaccacca caaacagatg gtaaagcagt tgtaacagaa gatgatgtag 36360 gtgcaggttc tacagttgaa gtagtaaata gtaacaatac aattgtatat aaaatagaac 36420 tttctactac agcaggtaac ggttcaacag gtgctgtagg ttatacagaa gcaggtttat 36480 atgcagggga taatttattt tgtatgagaa cttttgctgt tagaagtaaa gatgtctctt 36540 ctatattaag aattacttgg acactaatat tctaatatgt ctttgtataa tgtagatagg 36600 ttaaaagctt cgttaaaaca aggtggagct attaactcaa aatataaagt cgatataaaa 36660 atacctacat tattaaggta tttacctttt tttaaaacag tcgatgttgc aggtgaatat 36720 ttaagtgtaa tggctaatag aacttctata ccaggtaaat ctatgagtac tgttagggta 36780 tatcatcgtg gtcaaccttt tgttataaga ggtgctgcac agtttccaaa tactcataga 36840 ataacttttt ataatacacc tgatatggat atacatcagt tatttagtga ttggatgtat 36900 agaactgata gttttgacag tgtattaact aaatcatttt ttttaggtaa ctatgtagga 36960 tttaatagtg taggttcagg gtatatgact gatatagttg tatctcaatt atcttgtgat 37020 ggtacaactg aaacaaagtt taaactttgc tatgcttttc caatagaaat agctgaagtt 37080 gatcttaatg cttctggtaa agaattatca tcaacagaag taacatttgc ttacacatat 37140 tgggaaagat tataaataaa ttaaaaatgg agatttaaaa tgcctttata tacagttgat 37200 aaattagcaa atgctcttaa aggtggagca aaaagtgata agtattatat tgaaatagga 37260 acacctcttg gagcacctga agtagcattt acagaagaag atattatttt atgtaaaaat 37320 gcaagttttc ctgaaagaac tttaggagaa gtagaagcat ttgtacaagg tagaaaatta 37380 aaattaccag gagattctac atttgatact gcttggagtc ctgtattcta tcaaacacct 37440 gatcatgata tcagagctaa gttcttaact tggattgata aaatagatgt ttataaaaat 37500 aactatcata cttgtgaccc acatagctta atggttactt gtaaagtgca tcaagtaaat 37560 tgtaatggag atagcatagc aacttatgag ttctttaatg tatggccatc aaaagtaagt 37620 gaaattgaag tagcagcaga taaaattaat gctatacaag aatttacagt agattttaca 37680 tattctcatt gggaaaaaat agcataataa ctaggaatat aaatgagcct tgaaacaggt 37740 gaattaatta atgaagcaca aggtggatac aatccacctt ttgagctatc tacttataaa 37800 caccaagtaa aatttacacc acctgatgat tttgaaagtt atgtgaaatg ggaattatta 37860 ggtgatattc ctttacattt aaaaatagat gaaaaaactg gtttaataac tggtgatata 37920 gaacttctta gcaaacaacc ttcagcaaaa aatgatatat atgaatataa attaatgaaa 37980 atagatggta gcaattggag acatttaggt ttattaaaaa atggtcaaac atttacattt 38040 aattttcaag taaggttaac atatactatt acacaagaca caggtgtagg aggttctaca 38100 ttatcttcac aaactgttac agaagtaagt gatgttagtg ttacaatact tcaagataat 38160 gatataataa gtactttgtt ttgtaaaaat tatatagatg aagcaaaata tcctttaaaa 38220 ataggagata cagtatatgc agatgcagta gaatttatgg aaagccatcc taataggaat 38280 aattttaaaa taaatttagt ttaagtttac tttaaaaaac ttatgataga atattgataa 38340 gattatatca aaaggaataa aatcatgaaa aaaaagtaca ataatctttt agcatttggt 38400 tttagtctat tttaaacagg taacaaatgg ataaaataaa gtttttaaat aatttaggct 38460 atgaagttgt atctgaagac ttagttagaa atttgtatgt aaaatgtaaa aataatcata 38520 tttttaaaag agaatttagt gactttaaaa aaggatacat aaaatgttct aagtgtgaag 38580 aagagcaaaa actagaattt ataaaaggat taggttatga agttgttact atggataaaa 38640 aaggaaagtt attacttaaa tgtataaatg gacacattat aaaaaaatat tttggtaatt 38700 ttaaaaaggg aactactaca tgtaatgaat gtataaaaga agaaaaaatt aaatttatta 38760 aaagttgtgg ttatgagcca gcgtcagaaa acttagcaca tgacttattc ataaaatgca 38820 aaaacgggca tatttttaaa agagaatata atgatttaaa aaaaggatat atcaattgcc 38880 caaaatgtaa tgaagaagat aaggtaaaac ttataactag ttttggttat accataatga 38940 atcaatataa ctcagaagaa ttagaactca tgtgcaaaaa tggtcacata tccaagagaa 39000 tattccacaa ttttaaaaaa ttcccattat gtagtgaatg tgttgaagat aaaagaacat 39060 cattcataaa agaattaggt tataaagtag ttggaaaaaa cttgtttgaa tgtaaaaatg 39120 ggcatacttt tagcagagaa gtaaagagtt ttagaaaagg atatgtatat tgtccaatat 39180 gtagcccttc tattagctca tttgaaaaag aaatatcaga gctattaaca aactataaca 39240 aaaatgacag aaacatacta gatggcaaag aacttgattt ttatctgcca gaatataatc 39300 tagctataga atgtaatgga gaatactggc attctgagaa aatgggtaaa gataagaact 39360 atcatttata taaaacaaat aaatgtttgg aaaaaggaat acaattacta catatttttg 39420 aacactcttg gattgaaaag aaggaaatat ggactagtat cataaacaac aaattaggaa 39480 aatctaataa aataatggct agaaaatgtg ttttaagaga ggtatctaaa aaagaagaga 39540 aagaattcct aaacacaaat catctccaag gatttactgg tagttctatc tgctatggac 39600 tctactacca agatgaacta gtttgtttaa tgtcatttgg taagtctaga tttacagata 39660 aatgtgattg ggaattgatt aggctatgta caaaaatggg gctgaatgtt ataggtggtg 39720 cttctaaatt gttgaaatat ttcgaaaaag aaaatgaagg ttcattaata agttactcag 39780 atagacttta ctctgatgga tcaatttata aacaattagg attcgaattt agtcattttt 39840 ctaagccagg ttatttttat attaaaggta gtaataaata ctctagacaa caatttatga 39900 aacataaact taaagataaa ttagaaagat ttgatccaaa cttgactgaa tcagagaata 39960 tgagattaaa tgggtatcat aaagtatggg attgtggtca gggtgtttgg gtaaagaata 40020 ggaaggaata ttatgccacc agtaactaga ttaggagata ttgcattagg acatagttgt 40080 tatccacctt ctcctacaat agaagcaagt tctaatgttt ttgcaaattc aatagctgtt 40140 catagattag gtgattctat acagtcacac gcttgtcctg gaacaccacc acatggtaga 40200 aatagtgcaa gtggtagcac aagtgttttt acaaattcaa aagctacttg tggtataggg 40260 gacgctgtta attgtggagg tataatcgct caagggagta ataatgtttt tagaggataa 40320 taaacaacta tcaaaagttt taagcgataa tataattatc aaagaagata ataaaaatgt 40380 ttatattaag tttaaaaaga acataatatt agaaagtgat aataatgtta tttttttagc 40440 aaaagattat ataataaact cagctaaaga aatacattta aatcctgata taaaaatatc 40500 agttgatgat agtgttgatg atatagttaa aaaagtagat gatagtaaac ataaactaag 40560 cacacctaaa atagaacata atcataaaca ctgtaaacta aaatgtttta tcaaaaagat 40620 ttttaattta aattaatcct agaagctgtt acattgcatg ttccgcttac atttatattt 40680 gctgaacctg caactgtaac attataagat ccatttattg ttacattact attgccatct 40740 atagtaacag aattttctcc tttaatatgt tctgtattgt taccatcaat attttcgtta 40800 ttatctttta ctatattaat tgtaaccgtt ccttctttgt caattaatac ttctgttcct 40860 gttctatgaa aaatatgaat tctttcatct ccatttgaat catcaaattc catatagtga 40920 cctgattctg tttcaaacac ttgatttttt aaatattttt ctccccttga tttattatta 40980 gtatcaggtt gatttttata gttacttaaa ggatatttat ttgtagggtc tttaaatact 41040 tgtaattctt cgttttgatt attaacacct tttaatacac ccataataat aggttgattt 41100 ctatcatttt gaaataagtg tactaataca taagttcctt ttttaataaa gctagtaaat 41160 cccattcctg aaaataatga aaaatctaat gatgtggccc aaggcaatga ttcagtaggt 41220 atagtttcat catctattcc tatgattctt actctatatc tttgagattc taaaggatct 41280 ctatcatctt ctacaactcc tttataaaaa ggaaatgttt gagttatcat tttaagattt 41340 ttttcattta ttctcatgct gaacctatcc ttcctaatgt tattgtttgt gaaaaaacat 41400 taccagaaga tatatgatct attatcctag taataaaata ttctcctgta atgtaaggca 41460 tttttgcttt aaaactttct attgatgagt tagcattaaa acttacctta cacataatat 41520 tatgattaaa caatcctgct acttctattt caatagcaga actttctaat atttcagtat 41580 tatatataga atcaactata ttatgcaaat aaggaaatat ttttttacct tttattccac 41640 tactatcatc taaagttaaa gtagttttta aacagctttt ttcatgagat attttagtgc 41700 tatgttcttc ttttgtaatc ttttttgtat caacttgata tgttacacaa gatggtaaca 41760 tagcattttg tacaagcata tctccttgta atattttaaa gttttttaca gcataaggtg 41820 aatactcttg tgtttgcgtt ggagaaaatt ttactatatt agataaatca ggtgctaaac 41880 ttcctatgct atctgtaggc ataactacta taccttttct tgcatttata ataagtaaat 41940 catcaaattt ttgcatattg tttaaaacat ataataagtt tttatcccct tgtactacat 42000 aattttcata tgtatttttt ggagtatctt ttacagttat agttaatggt gtagatatta 42060 aatcagaact tgttaaaatg tcttttataa catctgttga tttaacattg ctatatcctt 42120 ttgatataaa agtattagct aacatgttat agtactcatc tactaattca aattttatag 42180 tacctactga ttgaccatta aaatccctat ctattttagt aactttaaat actctttcaa 42240 acttaactcc aaaatagtct ttaagtgaag ctttaaaaca tattccatta tgtggaggca 42300 aaagttcagt tactttttgc gtatcattaa atataacata accttctacg cataaatcat 42360 tataatccca aataaatgtg caatctgata tatttgcagg gtcaataggt atttcagttt 42420 ttttaccatt tgaatataat aatattgcat aataagcttc aggtaaattt gtaaaactag 42480 aatacattta gcatgccttt tatttcttct ttaaattgtg gtataaactc tctttttatg 42540 aatattactt ttcttcttgc ttcatttttg ttttgaactt ttgtaagtat ttgattatat 42600 aaatcatcag ctacaaaatt aggcgagtaa tattcttgtt gttgttcata ttgattatct 42660 gtattatcat ttacccatgt atcacttttt gcataattaa gtattccatt ttctccaaaa 42720 ttaagtatca ttaaaatatc ccaaagagat gaatcattat actctctcat agctaaaact 42780 tcaaatctta catcatcatt catttctttt acataaaata atgataaatt atttttcatg 42840 aattctctta gctttggaat atttacagca tatgtaggtg acaatgaaaa tccattaaaa 42900 cttacattta ttttattatt taatatagag tttttcatgt tataccttat aattgttctt 42960 gtgagtattt attattaaac tcttcttctg ttaaacctat atttgcttct ggtatttgac 43020 tactattttc gtttgtatta gtagttgttg tgtttgtatt attatcagaa gtcattctta 43080 atggtctttt ttcttcaaat tgtaaagaaa ccgctaaatc tctaggtaaa ccatttccat 43140 ataaagcaga agcttgcccc atataattta tattacacat tctaatattt aattcagttt 43200 ctcctgtttc actatgattt aattgtaaca tttcatttaa tactttttta agttgatcac 43260 ctttagtagg atctttagaa ccaaactcta tggtaaaaac ataatcttgt gaaattaata 43320 aacctgtttt atcagtacct aattgtgttc ctgtcattat tgattttagt tgtaacaatg 43380 ctttaactat atcttcagca tgtttagcat ttctaggcaa taacatagtt tcaaaattaa 43440 atattctatt tggtgttccg ttataaacac taataatatg tggatctgtt ctgatattat 43500 ttcgttttaa taacttatat ccaaaaggta gtgctgctcc agctgccata cctgctatac 43560 ctacaccttt tttaattcca ccttttattt ttcctttaac acctaatggt tttgtttttg 43620 gtgtaggtgg tgtttcaact ttattaaatt ttgatgattt attttttgtt ttttttaata 43680 atttactaag tattgacata tttttatcct attgcattac ctattggatc aacttcatct 43740 tggctgtatt catgactaaa tgcttctgct agtgctgatg gtataggaag tatccaaata 43800 tattcacaag gtacaccagg ttgtaatttt ggtccttgtt cccaacttac agggtctatt 43860 aaatttgata tattattttc tactagattt aataaatcat caaaagcttt agatggatca 43920 ttgtttacaa tatcattaat tgtatctttt attcctgaaa catcacttcc tattttatat 43980 gcttttattg caatataatc tctagctgtt gaatctccta ttaaatcata tatttgaata 44040 gtttgtccgt tatccataat ataccccttt actctttata aatatcactt tcttgtaatg 44100 aagtttgaga attgctttca ctagcattat atagtgaact tattttcttt tcccaatcat 44160 ctctccataa aggttttctt tcaataaatt gaatacttag tgaaaaatca ctaggattac 44220 catcatgcct aagtaataac tgccttgatc ctatattagt atttataagt gaaataaaaa 44280 atccttctgt aatatcccta gaagcactta ataatgttga tattaatggt ggtgtatcac 44340 tctgtaaaga tattatatca atacaaaaaa tatatttcat aactaaaaag ttcataggaa 44400 taacattgtt tacacttcct aaactgatag gatctctttt tgcttttgtc caatttttta 44460 atttacttat ttgttcaaca taagcatcat attgctttct tgatttaggt ataatattcc 44520 atgacatatc tatatttctt ggatttgaag acctataaac tgataaaatg ttaggatcta 44580 atcttatacc acttctagct aatgcttgtt ctgacatatc ttttatagat gtttttcctg 44640 tgtaattact tatttttgat atagcactac ctaataagtt catagactga acttcataag 44700 attgtaaata ttgatcagat aatgagttag gtaatggaaa ataaaaagtt cctactgcat 44760 cattagatat aactgcagaa tctctatcta tcattaattc aatagttctt tgtaatgtat 44820 tagcagaagt ttcagccaaa gaatctaaag atggattatc attgttttct tttatattag 44880 taatatcttc atcatttatt tgatttatta agttatccca agattccatt acttctttac 44940 ctatacctaa attatctata tcataagctg ttatttttag taaatgtttt tcttgttcca 45000 atccaggtat gtttatatta ttttccattt atactcctaa ctttttaaca aaatcaacag 45060 attcaacttt atttacattt ggtgttaaat tgtttgaaac tactgcttct tgtttattat 45120 ttattaagtt tatacctttt ttaaactctt ctttactaaa tcctgataac tcttcaaatt 45180 gttcgtttga accagtttca agcatatctt ctgttaactc tatgcctgta tttgttaaat 45240 agtactcttc tttagttcca tcatcatatt gtcttgtttt cttagttata aaattaccgt 45300 ctgatgagct ataggcatta tcatcaactt ttttataact tatgatagga taatttttgt 45360 taacaacttt aggtgatttt acaacttttt ttggttcttc tacatagtta gcatctcctg 45420 ttatagatac acctttgccg ttacctacat aattaggatc tactcctatt gctacacctt 45480 tggtgttatt tgtatagtta acatctcctg gtatagatac attaccttta ggtttaaatt 45540 catcttttaa tctattaatt tcagcattaa tttcttttgt atcttctgga gcatatttta 45600 atggtttacc accttgtttg ttaggttttt ctataaattt attttcttct ttaggtttaa 45660 attcatcttt taatatgtca acttcattat taatttcttt aggtttttct ataaatttat 45720 tttcttcttt aggtttaaat tcatctttta atctattaat ttcagcatta atttcttttg 45780 tatcttctgg agcatatttt aatggtttgt tattatatga aacttctttt ggttttgcaa 45840 tatcaatttt gttattattt gtataaactt tattctcttt ttgcttatta acattagaag 45900 cgtattttga accacctata tttatagaat aatatttacc actattactt gtagctacat 45960 tattagtttt aatatagtta ctatatttaa aagctttagg tttagttagt tcaggttttt 46020 tagttgtttt tgctacaaca tttttattat ttaattctag cataccatca ccgcttttgt 46080 ctgttatagt tgttggttga atatgccaac cttctttatt aggtatagga cgccaaaacc 46140 catactttga taacatacca tttgattcta actgctttgc ttcagtgcta ttgatatcaa 46200 ttgccattcc gtactcatgc aaagaataac caggtctatt agcaggattt cctttaccat 46260 taatataatc attgtacaac ttttcttgaa aagctgtact tctaaaccct gatgttacgc 46320 taaattgttt attatatttg ttataataat cataagccat taaatttaag ttatataata 46380 aatttccatc taagttgttt atagcagagc taaatggttc tgatcctaca taagaaaaat 46440 aaaagttaga tggatcaaaa tcattaaaca ttaaatctga tttttttgta cttattccat 46500 attttttagc ataactaaca ccgctttgag ttaattttgt agtttttatt aatccatctt 46560 taaacttaac attttctgtc tttattgtat tttcaactac attattagct tcaattatat 46620 tttcattagt agtgttaaca ttattagttg caggtataga ttgtgtatta gctttaaccg 46680 ctggtataac tttttcagtt acttgtgact taacatatgt ttcttcaaaa atgtttttag 46740 cttgtaattt tctattaaca ttaaaaaatt gtgcttttgt aagatttttt aattcattaa 46800 catcagctat gttataactt tgagatgcac ttttatcata tactacttta taaacttttt 46860 ctcctaaaaa gtttgtttta ggttttcctt ttttagtagt tataacttct aaagaattgc 46920 ttagtatcat atctttgaaa tcatttaaaa tatttggtgg taaaacatca tcaatatttt 46980 ctgaaaaatc atcataagta acttcataac tatttacaaa ataatacata gcattatgaa 47040 ctaacctgat aaatccttgt cttatatgtt gtttaccaat aattgatttt ttaaccatct 47100 catataaact aggatcatta tctttcatta aacttaaagt ttcaaaatag taatggtcta 47160 caaatttatt agttttagct tgtgtagtta tatattcaaa aattattaat aaatcaggtc 47220 ttaatttttt ataatattct atatttttac ttaaaatttc aatattaata ttatttaaat 47280 ctatgtagaa gtatataggt aaaccattta ctaaaacact accatctttt tttatttttt 47340 cagatatagt taatgctgtt ttaacaactc catctttagc tagtttaaat gtgtttacta 47400 taagctcatc ataagctaca atgattgcat tttttataac atttaaaaag gagtattctt 47460 cattattttc atccattttc attgtagtgt ctaataatac aaatgtagat gttattgcac 47520 cacctttact aaatattaat tttggaacta aggtaatagc ttttgtacca gaacttataa 47580 ttcgtatagg aggaaataat aaagcagtcg cacctaaaat ttttaaaaca ttaatactca 47640 ttgttttata taatgaatca tcattaaatc ttccatacaa tatcatatag taaggaatac 47700 catcatttgc catataatca gcaagtggtt taaacatttc ttctgtataa tttaaagttt 47760 ttaaaatagt ttcaattgaa gcatttttta attcttctgc atttattgtt acttctgaac 47820 cttgtaattg tattatatca ctcatcatcg tcctttttta acaatatttg tatttcaaaa 47880 gggtataaat tatcaaaatc agttttatta aatcgtaact catgtataaa atattttaac 47940 aatttataat agttttctaa atctaatctt atcacataat cactaaatag gtctactagc 48000 tctgtttcta tttcaacatt gttttcacac ataatacatt ttacagttgc attaagtttt 48060 aatacactat caccattact taattttgaa attatattat tataatcttt taatggcaat 48120 tgatcgcaaa ggtgtaaatt acttttagtt atattatgtt tttctccatt aataataact 48180 tcgacagcat ttaaaggcgt aaattttaag ttatccctta tttctattgc agtatcaata 48240 ggattattac aatgcgggca agtcattaat aaatctatac tatctccatt agcataagat 48300 gataataata ccataatata taaccttgaa atgtaatcta agtcttttgt ttcaggtatt 48360 aaaatatcag ctacactatt tatttgatct tccaaaggta actcatacaa atccataaat 48420 tgataaagca catttagttc atctttaatt ttccaaacat taactttata atcaattcca 48480 ctaatattaa tttttttaat caaaatagac tccttttaac agaatcaggt atctcattaa 48540 gttcaacatt tacttcttca ttacaattat tgcaagtgca tttttttatt aatttacatt 48600 ttggtaacat atcttgaaat aattttaaaa catcattaaa atattttata ggtatatttt 48660 caaaatagtt ttcaaagtaa acattatttc cttctagctg ttctccattt actaatattt 48720 tatcaactct ataatataat tctaacaatt gtttttcatg agttaacata tttttagttt 48780 tattaataag ttctaaggtt tcatcatttg ataaatcatt tttgaaacaa atagttatat 48840 tatcattacc tattttaaaa tctatagggt ttaattctat atctttaaaa actatatcat 48900 taatatcaaa ttcaacttca ttaggaatag cacataaagg acaactataa tctgcagtta 48960 ttttattatc aacttctgaa aagtattttt ttaaaaataa taatttagct tcatcatctg 49020 aaatatattt attttcattt aaacatttat atactaaaac atttattata tcactatcat 49080 aaacatagcc attttcatta tatattttgt taagtaaaat agaatgtttc cctttccaag 49140 tagttaattg catttaatct ctcctttata aatattatat attatttata aaggaatatt 49200 atggctatat taagcacagt tgttggtgct atatctagtt tttttggtgg agaagaaact 49260 aaatcatcta taagtcaatt agcacaaaaa atacaaaaaa catatagtat taattttgac 49320 ttagaaggtt tatatagtgt tgataccttt gctttaaaaa atgaagttac tggtgctggt 49380 agaattaata tacttagttt accaaatatt gatatattta tacaaagggt ttcaatagaa 49440 cctatttcat ttgctgaaat aaatgaatgg ataggttcta gttggagtta tacacaaggt 49500 aggcatgagt tacaacaagc aactataact tttagagata gcgatggagg ctttttatat 49560 tcagctttta ggaaactcac aggtcattta aaagatcaat accctgatga tcaaatgtgg 49620 ttattaaaag ttagaaaaag gactttaaga gaatcaagaa acaatataaa tcagtctata 49680 caaaatgatg agtttaaaaa aggtggtcat gtcgtattag atacacaagg tgctatgata 49740 agaagtttag gtgctttagt tttagatcaa aataacaatg gtttagcaac ttttgatgta 49800 acatttatat ttgatccttt cccaccagaa ataagttatt aaatataaat aaaaataaaa 49860 tggagttata aatggcaatt acaacttacg aacagtttca agcgttatgt ccaaagaatg 49920 gtgaaatagc agatcaagat gttttaggta aacctagttt acaattaaaa acagaacttg 49980 atacagttat atctcaagta aatttagtta taggagttca acaaccatca gactgggatt 50040 caggtacaac atatacacag aatcaaatag taaaatataa taattttatt tatgtttctt 50100 tgtctgatgc gaatgttgga aatcaacctg atacaaatcc tacaaaatgg aaaaaaataa 50160 gtggtggttc tatatcatca gcaattaata taacagttac agcaagtaat tataatacac 50220 ctgttacaga agtagttaat gcttctcttt catcaaaacc atctaaagtt tatgtaaatg 50280 gtacacttat tcaatcaagc aagtatacac atgattcagc tcaaacaaaa ataactttta 50340 caaatggaat gtcagtatat aaaaatgatg ttttaactgt agaatattaa taagtaggtt 50400 taaaacctac tttatatttt ttagtgctgt agttaagttt ttcttcaaaa taatccaatt 50460 cttttcatta gctaaaaatt ttatatactc gttagaatcg cataaattaa aactataact 50520 tttattatta acattaaatg tcaatacttt atttctatta tcatacttat attgaaatgt 50580 aatatttttt tcattttcta catatcctaa aactcctctt tttatttcaa caggggtttt 50640 atcaaaagaa tataatataa ttctacaaat gcttataagt ttattagatt ttaaaagttt 50700 ttgtacttct ttctgcaata attttggcat atagcataat actaatggtt tttttgatat 50760 tattattttt tttaattctt taaccatatt tttttcaaca aaagtcatat tagatacctt 50820 tttaataaat atttaaaata tttattttaa aaggaataca atgtatagta aattaataaa 50880 agatatagta actaatggtt tatcagaata tgcaaaagga aatgagttat tagctattga 50940 agaaagttta aaactactag aacaatataa tatagatagt ggtaatgagt tttgtgttga 51000 tccaattgta acattagatg attttataaa agaacttaat atattaataa catatcaaga 51060 ttttaataca tttcatgctg tgttgacaga aacattaaaa caaaataaaa attaatttat 51120 tttttaaaag aatctaggct gaaatcccaa ccatctttag tggttgggct gaaagcctat 51180 ccttgatttt ctatatattt tttgatagtt tcaggggtag cttcgccaac cgaacaagcg 51240 aagtacccat cgctccaaaa tgttttttct ttccaaaaat ttctgcaaag taaatgataa 51300 aatctcttat cttgccaaat tctaaaagta gtaatctgct taatttttct tataatttga 51360 gttattgaaa cttttggcaa gtattgcacc attaagtgta aatggtctat atcgctttcc 51420 attgctatta tattaaaatc actagtattg gctattttat caataatagc cttaatttcg 51480 tcatttagta atcctactaa aagctttttt ctatacttac atactaaaat taagtgggct 51540 tttagattat gcttacttct atttgttgaa atatagccgt gaagtttata attatttttt 51600 ctcatttttc ttgccttttt tatatatttt agatataatt atacaaaaat attaagaaaa 51660 agagaaatgc taagagctgt aaaatataga atttacccaa ataaagcaca acaagagctt 51720 attttaaagc actttggttg tgctagattt gtttataatc attttctaaa ttatagacaa 51780 gagcgatatg ctcttggcat aaaagaaact tattttacta tgcaatcaaa gcttactgag 51840 cttaaaaaag aacatacttt tttaagtgaa tgtaattctc aaagcttaca aatggctctt 51900 agacagttag ttactgcctt tgataatttt ttttctaaaa gagccaaata tcctagatat 51960 aaatctagaa aacatagtaa acaaagcttt gctattccac agaatataaa gctaagtaaa 52020 aatagagtta tcttgccgaa attcaaagaa ggcattaaag ctaaaattca taaaatccta 52080 agtaatgatt gtgtgataaa acaagctttc attagttgtg tagcaggaaa ttactatgtt 52140 tctcttagct atgaggataa taaatctata cctaagccag tagagataaa atcagctgtt 52200 ggtttagata tgggtttaga aaacttactt attagaagtg ataaaatagt ctacgaaaat 52260 aagaagtttt tacaaaataa agaagctaaa ctcataaagc tacaaaaagc cgtttcaaaa 52320 aagaaaaaag gctcaaataa tagagcaaag gctattaaaa aactagctat tgctcatcat 52380 agagttgttc tagcaagaga tgactatttg cataaaatca ctaatgagat aaccaatgat 52440 tatgatttta tagcgataga aaatctaaat gtaaaaggac ttataagaaa taaacattta 52500 tcaaaaagca tagcaaatgt aagttggcat aagctaatat ctatgctaac ttacaaagca 52560 gagctaaaag gaaaaactct aatgcaaata gataagtttt tccctagttc tcaaatatgc 52620 tctaattgtg gagtaaatac tggcaaaaaa gctctaaata tcagagcttt tacttgccct 52680 aattgtaata cataccacaa tagagatata aatgctagta taaatataag aaattatgct 52740 cttggtatgc ttgatgatag aagtagagta aaaatagata aatttagggt gggaatcacc 52800 cgaagttacg cttgtggaga tagctcttgt gggactagca aatacggtaa aatatttgct 52860 agttagcaat ctatcgttga aacaagaagc ccacctatct tttagtaggt gggtgattca 52920 ctactcataa ttaataagtt tttaataata tttgttatat aatatagcaa aaaataaaaa 52980 ggattattat gagtattaaa catgttgttt tagataataa cgtatttgga acgccaaaac 53040 ctggatttgc tttgaaaagc aagtttatat gtgataatta taatgaacag ttagaaaata 53100 taaaaatccc agttgataaa ttagatgaat tactaaatga aataaaaaca tttttaaaaa 53160 cttcttatta tgaatggaat ggtattgaag gtgatagtaa tatatttgtt tttaggttat 53220 ctaacatata tattgaaata acttataaaa taggtaaact tgttaagtta gatatgtatt 53280 caaacagtat agatttttta aaaggatttt ataacaatat tttaaagaaa tatgttactg 53340 gtactgatga gttattaatc aaaataaaga gtttctatga agaaaaaggg gaattagtat 53400 atgtagattc atctaaaact aaagataatt ataaaaatat tgattatgat tattaccctt 53460 ttctagattt aaatgaaatg tttatacagt ttctatttgc aaatagcaat attttaatat 53520 tatatggcca acctggaaca gggaaaacaa aacttgcaga atgttatcta aactttttgt 53580 taaatttgga ttataagaaa tataaacatc ttgaattaga agagaaagta tttgataagt 53640 cagatgataa ctgtaattgt ataaatgttg cagttgtaaa gaatgagagt ttattagctg 53700 gtgatgcgtt ctggaatgag ttattagcaa ataggtacaa tttagtatta tttgatgatt 53760 tagattatct attgcctaga tctgatattc aaaatggaat agatgcacaa cgaaatcagt 53820 ttatgtcaca ctttttatca tttactgaag gtataaataa tgatattaca tgtaaaacaa 53880 agtttataat tacaacaaat agaaatatta gtgagattga tccggcatta ttaagagcag 53940 gtagaacatt tgatatatta aacttaagaa aacttacaaa taaagaagct ttaaaaatat 54000 gggaaaataa taaattacct aaaaaagtat ttagtaagct tgtaagcgat gatattttac 54060 aatgtgagtt aagtagtatt atggaagaag agaagtataa aattatttgt aaaaacaatt 54120 ttaaacaata cttaaaagaa gaaaacattt cacatatgaa aaatataaac aataaaagaa 54180 taggtttaat ataaatttaa gtagttattt gatatattat aatatataaa tttcaaagga 54240 attatatgat tgaaaataaa atagttcatg ctgaagatga agcacaatat tatcttaact 54300 taccacatct tataactggt gcgttaacat cttttaacaa tactgttaaa gtatttgaga 54360 ataataaaat aattaataaa gatatattgt acaatcaaac tttaactaaa caaattgatg 54420 aagctataca aaactctatt gatgagttta ctagaactaa tggaaaatat gctaacaaaa 54480 tatatgttaa aatagacaaa gaaaatggtt acataacagt aagtgataat ggaagaggtt 54540 tgcctataga cacttatgtt attgcaacaa ctaagtttag aacttcaagt aattataact 54600 ttttaaaaga agaaaaaact gatagaatta caataggagc tcatggtata ggtgctaaac 54660 ttataccttt atttagcaca gaataccaac taaccactgt aactttagaa ggggatagag 54720 gaatagtaaa atgttttaat aatatgtcaa agatagaaca taaagaagat aaagccccac 54780 aatcatcaag taatggagtt acagttaagt ttaaacctga ttttgaaagg ctagaactaa 54840 aagaaattaa tgatgattta attaatcata tacatgcagt tatactaaac atagcttatt 54900 gtaatcctgg tatagatttt atttttcaag gtaaattagt aaaagtaaaa gattttaaag 54960 attttataaa atattattca gataagtttt ctatattata taatgataac gatgtagaac 55020 tagcagtatt tcctacagaa gaatataagt ttattcatat agttaattct cttgatttaa 55080 ataaaggtgg agttgtgtta gattatatat ctaataatat tgtaagttct tttacaaata 55140 gattaaaaaa tagatatcca aaaattacaa acacagctgt taaaagcaga ataggtgtta 55200 ttttgatact taaaaataaa aagaacttga gatttggcgg aggacaaaca aaagaagaag 55260 taaaaaatac ttttaaagaa cttgaattac ctacactaaa atattctgat ttcgctgata 55320 ttttatttaa aaacaattat attaaagaac ctattataga actgtataga atacagcaag 55380 aattagaaaa tagaaaacaa aatatttttg aaagaaaaga taaaaaagaa aaatttaatg 55440 ctaaacatac taaagctaca aaagaggcaa aataccttta tgtagcagaa ggagatagtg 55500 ctttagctag tttaattcaa gcagttggaa gagatgttaa tggtttctta cctttaacag 55560 gaaaaattat gaatgcattt aaatctacaa cagcacaaat gacaaataat caaagagtta 55620 atgatattat agaagctttt ggaatgggtc ttgaaaaaac aaattatgaa aacttagtta 55680 tagccactga tgcagactta gatggttctc atattgcagc tttaatgata gctttagttt 55740 ataaattaac acctaatgtt ttaaaagaag gcagggtata tcgtttaaaa actcctatta 55800 tatcagtttt agaaaacgat aaattaacaa aatggtatta tactttaagt gattttcaag 55860 aagatgaaaa aaatctacca aaaaatgcaa aagttgttta tatgaaaggt ttaggtagtt 55920 ggtctgctga tagttacaat attgtttttg gtaaagatgg gcttgaaaat tgtttagaaa 55980 aagttgaatt taaagaaggt gatgaactta taatagaaca atggatgtct gatacaggaa 56040 tagattttag aaaaaaagtt ttaggcacaa aatcttttaa tattgaaaat atttaaggtt 56100 ataaatgaca aaagatgaaa agttagagct tattgaaaaa gcaggtttta aagcagtatc 56160 agaaaactta gctggtgatt tagtagtgca atgtaaaaat ggtcatatat ttaaaaggtc 56220 ttttggacat tttaaagaag gagtaaaagt atgtcatata tgtgttaaca atgaaaaaag 56280 agattttata ttaagtttag gatataaatt attatcagat acagtaaaca aatatgtaga 56340 agtaatgtgt cataatggcc atacatttac taggctattc tcatctttta aaaaaggtgc 56400 tataaaatgt ccagaatgta taaaagaaga aaaaatatct tttttaaatg gtttaggata 56460 cactatacta tcaaataatt taagtaataa tttagttata caatgtaaaa aaaggcatat 56520 ctttaaaaga atgttttcaa aaattaaaaa tggtagagta aattgccctg aatgtgaaaa 56580 agaaaaatat aatcaaacta gaaaaaaaga aattatatgt tccaataaac acaagttttg 56640 tgttgatccg aatagattaa aaaaaggata tgtttgttgt cctcattgta aaagagaatc 56700 ttatattaaa ttaattgaaa gctttgggta taaaatatta aaatatgaca gcaaaaatat 56760 aactgttgaa tgtaaaaaag gtcatatttt taatagagat ttacaggtat ttaaagcagg 56820 atcaaagact tgtagtaagt gtatagaaga ggataaaata agtttattag caaaacttgg 56880 atataaagta gtatctgata gtttaggtga tgatcttaaa gtacaatgca aaaatggtca 56940 tatttttaaa agaacttttg cttcatttaa gagaggtaat gtcttatgta atcaatgcag 57000 agatgaagaa aaaataaaaa tgttgaataa cataggatat gaagtagtat cagaagactt 57060 agttaacgat ttagaagtta aatgtaaaaa tggacacata tttaaaagac cttatgataa 57120 ctttaaaaaa ggtgttcatc tatgtagtat ttgtaatcca agttctagta catttgaaca 57180 agagataaga gatataacag gaggtttttc agataaaaca atattaaatg gttatgaaat 57240 agatatttat atacctgatt ataaattagc aatagaatgt aatggagatt actggcactc 57300 agaaagtact ggaaaagata gaaattatca tttaaataaa actaataaat gtttagaaaa 57360 aggaatacag cttttacata tttttgaatc atcttggtta gagaaaaaac atatttggat 57420 tagtattata aacaataaac taggtaaatc taataaaata tttgctagaa gatgtgtttt 57480 aaaagaagtt aataaaactg aagaaaaaga gtttcttaat gaaaatcatt tacaaggatt 57540 tagtggtagt tctatttgtt atggtttata ttataataat gaattagttt gtttaatgag 57600 ttttggaaaa cctagatttt caaataaata tgattgggaa ttgataagac tttgcacaaa 57660 aattggattt aatgttatag gtggagcaag taagctatta aaacattttc ataaaaacaa 57720 taaaggttct ataataagtt attcagatag actttattct gatggaagca tatataaaaa 57780 attaggtttt acttttagtc attattctaa gccaggttat ttttatttta aacacggtaa 57840 gagttttaat agacaacttt ttatgaaaca tttattacat tcaaaattag atatatttga 57900 tgaaagtaaa actgaatcag agaatatgtt aataaatggg tttcataagg tttgggactg 57960 tggacaaggt gtttgggtta aataaacttt aagaataata tggtataata taaatattga 58020 aaatgaaagg aaatatatga caattaatga aatgtttaac aacgacttat gtcagtatgc 58080 ctcgtatgat aatgtaagaa gcatagctaa tatagttgat ggattaaaaa tttctggaag 58140 aaagatagtt tatttttcaa aagatttaaa agattataaa aaagtatcta cattaaaatc 58200 agaaatatct gcaaaatcac aatatctaca taacgaagat attctacctg atattattat 58260 aaattttgca agagattttg attgtggtcc tgttatgttt cctttattta aacctttatc 58320 tgctgtaggt agtagaacta aacctgttgc agcacaacct agatattcat ctgttaaaaa 58380 gtctgattat tatgacttaa tgtttaacaa agatgatgaa gatattttat atcatcaata 58440 ttttgaagga tttaaaatag aacctaagtt tttattacct actttacctt tgatattatt 58500 aattaataat aatggtatgg gtgtaggttt tgcacaaaat attttaacaa gaaaccctga 58560 tgatgttata gaatgtataa aaaaatattt aaaagatggt tctattgatt ctgaatcaat 58620 agttttaaaa ccttacttca aaggctttaa aggagaaata gaacttttaa actcagaata 58680 tggtaaaaga caatggctat ttagaggagt ttatgaaaag gttaataatt ataatataaa 58740 aataacagaa acaactccat tcgcaactaa tgaaagtatg ctaaatcatt taaacaattt 58800 aaaagaaaag aaaataataa aagattataa agattattct ataggagata aatttgaata 58860 tttattaaat gttggtggag atttttggaa taacaagaat atacataaat taatagggat 58920 tgaaacaaca gacgtagaaa actttacatg tgctgatagg aataacttta taaaaactta 58980 taaaaatgaa attgaaattt taaaagatta catagatgtt aaattagaat atatacaaaa 59040 aagaaaagat tttaaattaa caaaatatga tgaagatatg agcttattat cagataaaat 59100 aaattttata aaagcaattc ttgataaaaa aattataatt gaaagaagaa aaaaagaaga 59160 tatagtaaaa caaataaaaa aaataggtat agacaaaaat atagatatgc ttattaatat 59220 gccattatat tctttaagtg aagaaagtat aaataaattg aatgatcagc taaaaggtct 59280 tcaaactaag tttaacgagt tattgcaaaa acctattgaa gatatatgga tagaagatat 59340 aaacgcatta tgttaaaaga ttatgattta ctcataatct tgatatattc atttttattg 59400 tgattatatc aaggttatga aagcattttg taatttatat ttttcatgaa taatcataac 59460 ctgaatatta atgaacgcat aaggttaaat cgcaggttta ttataaaacc cctcctttca 59520 ctactcttaa ctcattaacc tggcgttctt ttattgtaaa aaggatagat atgaaattta 59580 attgtaaaaa ttttgcaaaa acattatatt actctaaaga tataaatcac ataataaaaa 59640 tatttaatta tgctaaacaa gaggataaaa aacaagcttt acaaatttta ttatgggcta 59700 gagatgttaa tggtggcaat ataaaaagtt caattgatgt attagaatac atagctgaaa 59760 aaactgatga tatattaaat gatagtttct taacatctgt tgtaaaatac ggatgcttta 59820 aagatttaaa tttaatgttc tatgtagcaa ataaaaataa taaaaatata attttaaatt 59880 attattgcaa taatttaaaa aataaaaatc ctatggctgc aaaatgggtt ccaagaaaag 59940 gatctttatt ttatgcttta gcaaatatga tgtgtattaa aataggagat tttagaagat 60000 atgtaacaag tttatatatt tcagtagaag ctaaaatgtg tgataatatg tggaataata 60060 tttctttaga agaaattcct gaaagagctt taagaaaata taaaaaaact ttagaagaaa 60120 gattaaatat aactgtaaaa tgtaaaaatc caaaacaaag aaaattaaag tttaagggat 60180 gtgaaagaaa acttaagtta tactactaaa taacttaagt ttaattttga aaggataagc 60240 aatgataaca ctatcaaaag tattattttt gctatgtgtt ttagccacaa ctctacaaac 60300 ttcaataata aaaaataatt ttgaaaataa tgaatatgaa attatttcta aagaaagatt 60360 actacaatta aaacaaaata tgtctaatca catttcaaaa tacaataaag aaaaagctga 60420 tgaaataaca aattatattt ttgaagcgtc tattaaatat gatttaaatc ctgtttttgt 60480 aatgtcaata atacaattag aatcatattt taaaacaagt gtaacacaca aacacaaaaa 60540 tgtaaaaggt ataagtggaa taaattataa tttatggaaa gatattttat cagaaaataa 60600 tataaatcat ataaaaactt taaaaaatca aatagaagca acagcaataa taattaaaga 60660 ttttcaaaga agatataaaa caaatgataa gttaaaaata ttgcattatt ataaaggaac 60720 aggttatgac aaatatttaa ataaaagtgg tttatcccta gcaaaacata attataaagt 60780 atatgaaaag aatttagaaa aaatatacag ataaaactta cattaagtgt tattttgtta 60840 taatttaaat aaaaaaggag taaaaaatga gtttaaaaat tcaagttgaa aatatagaaa 60900 aacttattac agtttatgtt ggtgagttat cattaaaaaa ttatactaaa gatgacatat 60960 caaaaaaatt atatgaaata gaaaatgtaa taaaagaata tattaattct aacagtgaaa 61020 aaaaattaat tttaggatag taatatgagt atctttgatg aatattgttt aaaaaatgaa 61080 ttagatgagt ttcaaacatt tttaataaaa aacttagaaa caattataaa aaataataat 61140 ttttctgaaa atttgtttga tgaaataaaa aataaattta taaatgcaaa aaatataaaa 61200 tataattgct cggaagatgt taaaccaaaa cattatacaa aacttgcaat agaacctata 61260 aaattaattg ttgaacaaaa cttaaatttc tgtgaaggaa atattgtaaa atatgtttca 61320 agattaggaa aaaaagatga agacaaagca gaactaaaaa aaatattttt ctacttcgat 61380 tacttaataa ataaaaatga tactttaaca aaatctacat ttaacacctt aaattaataa 61440 ggtgttataa attaacaaaa accgcactta aatacaaaaa aatataaata caatacaaac 61500 tactatataa aatacttttt taattctatg cttattttta ttaatctaat ctatacttat 61560 tttttaacaa aactatttaa ataaaaaaat attttttcta aaaaaataaa ataaaaattt 61620 tacaaaaaaa ttttttaaaa aatttttttt cttacttata taatatatat tttttttttt 61680 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tgatttttaa 61740 attttagttt ctttcttaag tgcggtgttt gaattttaac ttttgtttgt agtattatct 61800 taagtattga ttaagtaata tttagatata cttttttaaa ctttatttga aaggataaaa 61860 atggatttat gtgaaaagga taaaatatta ggaatgctaa acgatttatt cttaatagag 61920 cctgtgtttt ttaacgatga aagaatatct ttaacttatg aaatgttaaa caacaatatt 61980 tcagatatta aaaaaatgaa agatgaagat attaaattat cagaagttat agttacatta 62040 catacaagta gcaacgaacc acttaaaatg gctagtacag cattaacaca taatattagg 62100 tgtatgtatt tagacaaaga aagtattata gataaaatgc ttagcttatt tgatatacaa 62160 gtaggagtta ttgtagaact tttagaagca aaggtatcag attatatgag tgatgaagtt 62220 tatacattaa ttaataggat aaaaatatgc atgatgtaaa aataaatgaa ctactagaaa 62280 acaaggtttt attgtttaat aaattatttg attatagaaa agaaaaagat atgttggatg 62340 attgtatttt agatgttatc atctcttttg gtaatgacat aaatattgat cctgagctaa 62400 tagcttctga attgtcagat tatcaagcat ttagaaatat agttgagcaa gatcttaaaa 62460 agtttaatta tattaaatct aataaaaaat atttttgtat tgaagattgg aattaaatgg 62520 acaaaaaact acattattat gatatttaca atatttctaa tggtgttttt ttaacatttc 62580 aaaaaaattt aaaagaaaga cttttatatg tatctcatag taaggagata atggataaaa 62640 aaatgggatt ttatccatta aactttactg ataggaatga ttttatttta ttatgtgttt 62700 atataatgtt taagtatagc ccatctagta tttatggatt atgtgagtat ttgaaaacat 62760 ataataagat tgaatacgat aagtttaaaa atactataaa gttttataaa aatattataa 62820 aaaaagatgt tacattatta gaagaaaaat ataaaaatcc tatgtttaaa caagttatgt 62880 atgaatacaa caaaaagcaa atatcatttg ttacattgta ttggtattta attttgtatg 62940 atataaagga atttaatgga attaataaca ccattgtgtg tgaatctatt ttaaatgtgt 63000 ttaagttttt aacatttaaa gatgaatcaa aagattatat aaaaaatata tttaaacaaa 63060 ttgaaggaga ttgtatatgg cattgaatgt aggttattta acttgcaata ctacagcaga 63120 aggtgatgaa gtttatacac cgttttatgc tgttgaacct ttattagagt ttatagataa 63180 agataaaaca atttggtgcc catttgatga agactggagt gcttttgtac aaacatttaa 63240 agaaaatgga tttaaagtta taaactcaca tttaaaagat ggaaaagatt tttttgaata 63300 tgagcctgat gattatgatt taataatttc taatcctcca tttagtaaaa aagatgaagt 63360 tttgaaaagg tgttatgaat taaataaacc ttttgttttg ttgcttcctg taaattctat 63420 acaagggaag aagcgagtaa gttcattcaa aaaatatgga ttagaattat taatatttga 63480 tttaagagtt gattatcata ctaatggtaa tttagaaaca tatactaaag gaaatcattt 63540 cggcagtgct tatttttgta aaggatttct tcctgaaaaa cttgtattta aagaacttaa 63600 aaaatatgaa agacctttaa aataatttaa agcataaaaa tgatataatt ttattaaaaa 63660 tgttaaagga tttgttttgg aaagcataaa tgataaagaa tatatatggg ctgaaaagta 63720 tagaccaaca aaaataaatg atatgatatt gccagaaaag cttcataaaa aaataaaaga 63780 atggataact tcaggtgaga taccaaattt aggttttttt agtaataccc caggaacagg 63840 aaaaacttct ttaaataaag ctatttgtgc tgaattagga gctacacatt tgtttatcaa 63900 ctcatcaaaa gatggtggta tagatttagg tagaaatcgt attagtagtt ttgcaagtag 63960 tgtttcaatt gatggatctt taaaagttat atctttatca gaatgtgatg gtatgacaaa 64020 tgagcttcaa agagctatta gagatattat agatgcttat tcacaaaatt gtaggtttat 64080 actaactgct aactacactg ataggttaat agaacctatt ttaactaggg tagaatgtat 64140 agactttgat aaagagttta gagataacaa agtagaacta tgtaaaaaaa tattaaatag 64200 gcttaagttt gttttagaaa atgaaaaagt tgaatatgat gtaaatgacc ttaaaaaaat 64260 aatattaagt ttttaccctt gcataagaaa aatgtttttg gttattcaac aaaatactat 64320 agataataga ctttgtatag ataaaaaaac atttgaaact cttgaaagca atgaaacaat 64380 tgaaagccat gcttatttag ttagtgcttt aaagaaaaaa gattatcaag aagctagaaa 64440 agttatagca caaatagtta attatagtga tttctataaa tacttgtata aaaacataga 64500 tagaatattc gaagtagaaa gcattcaaca agcagttgtg ttaatacagc attattatta 64560 tcaagataat acatgtagag atagagagct gtgtttaagt gcattaattg cttctatgat 64620 taaacaagat ttaaaatata aataattaaa aacaaaggat taaaaatgta ttcaaaatat 64680 ttgggagaac ttgaacaatt aaatgaagca aaagagtata aataccaacc taaaacaaaa 64740 aaagaattac aagatttagt ttatgatgaa agtgtagacc tatctttaat tgatacaaga 64800 cttataactg atatgagtaa cttatttaat agcgtagata gggatataac aggaattaaa 64860 aactgggatg tatctaatgt agttaatatg aacagcacat tctacaaatg ttggtttaat 64920 gataaaacag ttgatttaag taaatgggac actagaaaag ttaaaacaat ggatcaaatg 64980 ttttcaagat gtgatacaag gtttaaaatt tctgggtgga atacacaaaa tgttgaaagt 65040 atgagctata tgctttcatt taacacaaca tttaatagtg atttatctat tttaaatgta 65100 aaaaaagtta aaaacttttc tggcatgttc tataatgcaa atattaatca aaaaattata 65160 aagtctatag cagatatgtg gagtttaaaa ggttctatta actgtgaaga aatgtttaaa 65220 gattacaaag ggaacattag taatattgat ttttcaaaat gggatttatc taaaggaaaa 65280 tctaaaaata tgtttgatgg tgttaaaata gactattcaa attatccaaa aggtattaag 65340 gtttaatatg tttagtacta tactttcatt tgtaaagtca aaaataattt atataatcct 65400 agcttctttg ctaggatttg tagtttatag atatatttca ttagaaagat ctaatgcagt 65460 gttaattgaa aatgaaaaac aattaataca aaacatagat gaatctaaaa aagaattaga 65520 aacacttaaa atctataatg aagttactgt agagatattt aaagaaaaag aaacaaaata 65580 caaagaagtt cttaataata tcaaagatgt tgaaaccaaa gttaaacagt taaaacctat 65640 tggaaaggat gacaatgaaa cacagtatgt tattattgat ttttagtgta tttcttttta 65700 caggctgtgc aactgctact aaaactataa ctgtaactaa aaaagaatat ttaaaatatc 65760 ctcttgatga aaaatatatt ccaaataagt tatcagtaaa aataatgaaa caagagttta 65820 atggatcaca atacctatta atatctcctg atgattttat tacaattcat aatcagtaca 65880 aatacctcga atttaactac aataatcttt ataattcagt acaaaaattt aattctcaaa 65940 ttaagtaatc attaagagtg ttattgatat aatactctta agtattttta ttattaaagg 66000 agttgaatga agttttaata ctattacttt atagtaaaat attttattaa tttagaaagg 66060 atttaaatca tgtcattagt tgaaaaattg ttgaagtcta caactttaaa agacagagca 66120 agtgttatga acgaaagtaa atattttggt aaaacagaat ttgtagaaac agaagtgcct 66180 atgataaact tagcacttag tggaaaagta gatggtggta ttagtcacgg tttgactgtt 66240 attgcaggtc ctagtaaaca ttttaaaagc aattatgcac ttgtaatgat gtctgcttat 66300 ttgaaaaaat atcaagatgc agtttgtatt ttttacgatt ctgaatttgg tattactcct 66360 gattacttta aaaactttgg aatagatgct tcaagagtta tacatactcc tattaaaaat 66420 attgaagaac ttaagtttga tattgctaat cagttagaag ctatagaaaa tggagataaa 66480 gttataattg ttttagatag tttaggtaac ttagcatcta aaactgaagt tgaaaatgct 66540 ttaaacgaaa aaacagcagt tgatatgcaa agaagtaaac atataaaaag tttatttaga 66600 attattacac cttatttaaa tatgaaacaa atacctatga tttgtgtaaa tcatacttat 66660 gatgatttaa atagtctttg gggtggacaa gtagtttcag gcggtacagg tgtaatgtat 66720 agtgctgata cagtttggac tatttcaaga tctcaagaaa aagattcaaa taaagcacta 66780 caaggatgga attttacaat aaatgtagaa aagtcaaggt ttattaaaga aaaatctaag 66840 atacctattc tagttacttt tgataaaggt gttagtaaat ggtcaggttt ggctgattta 66900 gctattgaaa tgggattttt agaaaaacaa ggctacagtc attataatcc ttatacacaa 66960 aataaattac ttttgaaaaa tgcaacagaa gaacaactag ataaattttt taatgagttg 67020 ttatcaaata aagattttaa agacgcttta gagataagat actcgttaat taatggaaac 67080 aataaagatg aaaataattt agaagctgat gaataaacat cagcttaaaa aaggattgat 67140 atgaaaatta aagaattaac atcaaagata tttacttttg aaacatttaa aaaaatattt 67200 tgcacatatg attttaagaa tgacattata gaaggagaaa atggaactaa gtacagtagt 67260 caatttttct ttgttgatga aggtggatat atttgtaaga ttagtgatgg aaaatcagta 67320 ggtgttttag caaaaggtta tacatgaaat tattagtagc aggcagtaga gattttaacg 67380 attacaatct tttaaaagat gctattaata aacttaacat aaatcctgat ttagttatat 67440 gtggtatggc tagtggagct gatatgttag gttacagata tgctttagaa aataatataa 67500 acatagaaaa acataagcct gattggaatg cttatggtaa aagagcagga attttaagaa 67560 atcaacaaat gtctaacagg ttatccgaag aggatattgc aattattttt tgggatggag 67620 aatcaaaagg aactaaaaat atgattgatt tgctaacaaa aaataatatt aaaaaagaaa 67680 taatttttta taaggagaac ttaaaatgaa caaacaaatt actttaacag ttataatttt 67740 ttattgtcta tttatggtgt ttttaaactt tgtaagcttt ttatctgtag gttatgtaat 67800 ggaactttca gcattaatag atggaatggg ttttgatgga gattttggaa cagagtttac 67860 taaaatatta tatgaaacat atcttgatat ttttgcagca tttgtagtaa cattcttttg 67920 ctttttagct ttaatatttg gcaaaaatac taatgttatt tatggtatag caatagcagt 67980 gttcttagtg tatatggttt ataacttaag ctcaggtgca tattaccttt atgaatccta 68040 taacgacatt tatgtagttc aataaaaaag gttaatatta tggtactaag caaaaaaaca 68100 cttgtaaccg atagatccaa agaaaaattt ttctttggag aatattcagg ttttcaaaga 68160 tatgattggt attcacataa tcaattagaa aacttagata gaaaacaaca agcacagtta 68220 tggtttcctg aagaaattag tatgatacat gaaactaagt cttttataga attaccagaa 68280 cataatcaaa gacaaataaa agcaaactta acatttcaaa cattaatgga ttcaggtcaa 68340 aatagaggtt tagataatgt attaatacct ttagtaacat catcagggtt agaaggttgt 68400 ttaaaaacac aagcttattt tgagtatatt cattcaagat catactctca tattataaaa 68460 agtgtttttc caaatcctac cgaaatattt gatgaatatt gtgagtatcc tgaaataaaa 68520 aatagaatta atgatgaaat agatacttat gaatctttgg aaggtaattt agaagaaaac 68580 gatgaaaaca agttaaagat tttagaagct tgcttaagaa ttcaattttt agagggtgtt 68640 aagttttatg taagtttttt aaccacttat atgattaata agtacagtgc aggtggaaat 68700 aaaataccta acttaactaa aattataaaa ttgataaata atgatgaaga cattcatctt 68760 gtaattttta gttttataat aaaaactctt agaaacgaac aacatcaagg atttaaacat 68820 ctatttaatg aagacttagc attaaaagca caaagtatag ctagaaaagt atacgaagat 68880 gagttacaat gggctaagta tttattatca atgggtaata taccaggatt aactattgaa 68940 aatatagatg gatttttaaa gttttttgtc gatgataggt tgaaaaaatg tggtttccaa 69000 cctatatgga acgctcaaaa aactgattta gttaaagagt ttcaagaaat aaaaaatata 69060 agtagtgaaa atcaaatgct tcaagaagtt gatagtatta cttattcaaa aggtgtaatg 69120 gtaaaagata ctaatttaaa agtatatgat aacttaagct tagaagatga gttagaaaaa 69180 atattaaatg gagatgaaaa tgctaccagt taaatcactt acagaattag atgacattga 69240 tattaatgtg attaaaagaa atggggctgt tgaaaaatac agtcctgata aaatgtataa 69300 ttttttaatg aaagtatgtg ataataaaga atcttatgca atgaatgttt tatctaaatc 69360 taagataaaa ttaagagata acattaagat acaagattta tatgatgaga tattatctac 69420 tactgtaaat gaaataagta tgttgtatcc tatgtatgaa aagtttgcgg caaaattata 69480 cattataaaa tatagaaaaa atatgggcga taatataact cttgctagta ctttaaaact 69540 aggtttatca tcaggaatat attctaatga gtttgttaat agtttttcag aagaagaaat 69600 caatgaatta gattcttata tagataatga tagagattac ctgtttcaaa attataaagc 69660 tataagcatg ttttatacta agtattgttt aaatagaact aaaacaataa aattagaaat 69720 tccacaaata acttatatga gagttgcaat gtttttgtgt atgaatgaaa caaatagaat 69780 tgaaaaaata aaaaggatat acgatttaat ttcaacacat aagtttacat atgctacgcc 69840 tataatgcta aactcaggaa ttaataaagg acaattatca tcttgtgttt tagctaaaat 69900 gggagatgat tcacattcta tattagctac aaatgataac cttgcaatat atagtaagaa 69960 taaaggtgga acagcttgtg atatttcagc tataagagct acgggttcta ccatagatgg 70020 tgttggtgtt tcatcaggtc ctataccttt tataaaatta ctagatgcaa ctatatcagc 70080 ttggaatcaa ggatcaacaa gaaaaggaag ctgttgtgtt tattattcaa catggcatat 70140 ggatgttcaa aatttaatta tgctaaaaga taatggtgga actgaatcaa ctagagcaag 70200 aaacttacaa tatgctataa aaatagatga tgtttttgta aaaagatggt acaataatga 70260 aaattatact ttatttgatc caaaagacac accaaaatta ttagattctt ttggggatga 70320 gtttgaaaag ttttatttag aatatgaaca aaaatcaagc attagaaaaa aatcaataaa 70380 tgctagagaa ttatttgatg aaattttaaa gtatagagtt gaaacaggaa atgtttatat 70440 attttttata gacaatgtta acaaacaagg aatgctaaat agacttgtaa ctcaaagtaa 70500 tttatgttgt gaaatagttt tacctacatc agccccttat aaagttgatg aaaaacttgt 70560 acaatatatg tgattaagtt tattataaga tgattaatga tataatcatc ttataaataa 70620 ttaaaatatt aattaaaaag gattaaaatg tattcaaaat acttatgtga agctgaagaa 70680 gctaaatata aacctgaaac atcagaagaa ctaatagaat tgcttaaaga tgaatctata 70740 catcttggtg atatagatgt aagtgacata gaagacctaa attatgtttt tgatggaagt 70800 aacagaaaag attttagtgg tatagaaaaa tgggatgttt caaagataag tgaaatgaaa 70860 ggaacattta gagattgtaa atatttcaat cacaatataa acaattggaa tgttatttct 70920 ttagaacaag cagaagatat gtttgcagga tgtgaaagtt ttaatcagcc tcttaataat 70980 tggaagttta gatacctaaa taatacttct tatatgtttg aaggctgtgt taagtttaat 71040 caagatttgg acaattggaa tatgtctact gttagtaaag ctaatggaat gtttaaaggt 71100 tgttcaagtt tcaatggaaa catagatgat tgggatttaa gaggatgtgt agaagcttat 71160 gaaatgtttg aaggttgcaa atctttaaca agagacctat ataatatgga tataggaagc 71220 cttaatgttt ttgaaatggg aatagataca tctatactta aaagaaaacc acgcaattgg 71280 cgtaaatact aagtaaaaat aaggataaaa aattaatact tattaaaaat acttatgtga 71340 atctgaagta tatataaagt cttatgttta aaagttttat aaccaaatag aatatttagg 71400 catttttcca aatgatttta tggataaagt agaaatagat tctgatgata ataaaataac 71460 tatatcttat aatgaatact cataaactag aaaaggtaat agttttgatt atattgatgt 71520 agtagaaatg cttattccaa tgttataaaa aaatagatgg aaaacaacct gatgttttag 71580 tgttgatcag aaaagatggt gataattatt ttgatataca tgatagtgaa tatgaatatg 71640 tagaagataa tgaagataat tatttattaa atgatcaagg caatagatat ggttttgttg 71700 aaaatataaa tgatgagtat tctctttggg taagataata taaaattaag tttattataa 71760 ggtgattaat aatataatca tcttataagt ttttgaaagg aacagtataa tgataaacaa 71820 aaaagaatta ataaatcata tgtattcaga aatgttacat aaatgtttaa atggaactga 71880 aactgttgat aacccatatc atttggaaaa aactgtatta gatcacacaa taatggtatt 71940 aaataaggtt gaagatttat ttaaaaatga taaagattat aaagttttaa tgtttggtgc 72000 agccttacat gatttaggca agatatttac aagagaagta gtaacaaaag atgatggaac 72060 agtaaaaata agatttctta atcatgaaaa tgttggagta tattatgctt gtgatgtttt 72120 atctaagttt aatttaagtg aagaagagat aataaaaata ataaaaatag ttgcttatca 72180 tgatatctat aaatatgata tagataaatt aaaacgaaaa ttcacttatg atgatttgca 72240 attattatgt aaattttcaa tatgtgattc attaggcaga gtaactcata cccaaaaatc 72300 aactgacata tataaacaga taagattatt aaaaccttac gaaacaaaac ctattgatat 72360 aacaaaacca actataacaa tgttaatagg tgttcctgga gttggaaaat caactttgtg 72420 taatcaacat gaaaatgtaa tttcaagaga tgatatattg atgaattatg gtaaaacaaa 72480 atttaattta aatacatact cagaaacatg gagtaaatta tctcaagatg accaaaaaga 72540 aatagataat atctttaagt ttaagttaaa tagactacta caacaaggta aagatatcgt 72600 aattgataaa acaaatactt caatgaagtc aagaaagtct ttgttaaatt catcacaagt 72660 ttgattaaaa attacaacaa agttgcaata gttatgttat gcccctacaa cacaatacta 72720 gaaagaattg aaaaaagatc actagaaaca ggtaaagaga tatcaaaaga tattgtggat 72780 aattttataa aatctatgtg tttacctaca ttagaagagt ttgataaaat tacttttaaa 72840 tggtcaatat aaatattatg taccaaataa tatgaaggaa tataatgata caccttaatt 72900 tattttgcag ttatgtaata ttttctgttg ttacttgtgt tacatttaat gaaattaata 72960 atagtgaata taaaaatata atagtagagt ttatatcaat atttatattt tttatatttt 73020 tttttgttat cagttaatta tttatagaaa ttttaatagg gataaagttt aagataattt 73080 gtgttaagta catttaaggg gattaatggt ataatcccct taatatatta tgaaaggatg 73140 taaaaatatt ttgtaacttt ttgtttagta ttatctgttt tattgtaagg ttcatctctt 73200 tagctttaac agaaaaataa ctatacagta atgcttattc taaattatat gaggattgtg 73260 aaatgacacc tgaaaaaata caagaaatct ttgaaaaagt tttaaaagaa aaagaaaaag 73320 aatatactga tgaaaaatta gaagaaataa aaaaagaaag agaatatgtt gaatatattg 73380 taaatgaggg tattcacaaa acgatttctt tgataaattt gaaatattag aaactccaga 73440 aaaatatgat acaattaaat attttcataa tttaactaat aacaagttat gggctttaaa 73500 aagacaagaa gaattattag ataaatgaat gtttataaat aagcttaatt taaggatatt 73560 ttgatacaat atccttaaaa gctttaaaag gaaagaaaat ggatataaaa agattaaaag 73620 aatctttaga aggtaaagat aatggaaagt atttttgtga aatatttaac gctaatgttg 73680 atattttagt tgttgataat ggtatgaaaa aaatctgaag caattattca agtcttagaa 73740 gatgtaaagg aattatataa aaatgactaa acaacttata tacaaggctg aacatcttgt 73800 tgttaacaaa gataattaca gaaaaactac tacttatttt aatagtttta tggagatgta 73860 ttcttttata aaaaaactct aaaacgagat atagagttta tctagatgat atagattcat 73920 ctagagtttt caggaaactt tttataaaat cttatacgga attttataat ttttataagt 73980 tttatatgaa gtttatattt taaggagaaa ttatgaaatg gattaaaata caagaagacc 74040 ttataaatta taatgatata caagcatttg cgtcttatat tgatttttat cgtggtaagg 74100 ttgaaataat actaaaaatt aaattaaaag gaagtaactc agatattaat tatactttat 74160 tcgaagaaga tttttgtaaa gataaaacac actattataa tttaagaata aaatatatga 74220 aatcaattga aacacaaatt aaggatatag aactaaataa caaatatttt tatgagcttg 74280 aattaaatat ataaatagtt tatatctaat ttaataaaag gaataatatg aatgtttata 74340 gcattttttt aaatgagagt tctattgatg aaaacaaaga acttataaac aaatgtgctg 74400 atgcgttaag taaaaaaata gatgctgatt atacaattac tgaaaaaggt gatcaaacta 74460 taattagcta taaaatgaaa gacgataaag tatgtgatgt tgtatttgaa aatcatgatg 74520 aagtaacact taaaaaagtt aaagattctg gtcatagaga aatacaagtt gacaaagtta 74580 taaaaaggtt cactgatgct ttagcttctc cagttttaag atttttagta gatcataata 74640 aatttgtaaa aattgatgaa tcaagaagtc gtataaatag agaagtattc aataaattga 74700 aaaatcgtta atgtcaaaat tcaagcaagg tttttataat ccaacaaatc ctaaaaaata 74760 tatagatgat gtaacaaaca tcatctatag aagctcatgg gaatataagt ttatgttatg 74820 gtgcgataat aatcctggtg ttctcaaatg gtcaagtgag tccataatag taccttatga 74880 gtttttagga aagaagcata gatatttccc tgatttttat atagaagtaa aagacaaaga 74940 taataacata aaaaaatatc ttattgaaat aaaaccacaa aaagatgcag tttttaaaaa 75000 accaaaaaca attacagaaa aaaacaaaaa aagagttgta gaacaagctt taacagtttc 75060 aaagaaccaa gcaaaatggg aagcagcaaa agaattttgt aaaattaata atatggagtt 75120 catggtattg acagaaaatg aattgtttaa gtaaaattta atatacttta atgtatacta 75180 tattgaataa aaaatttgga gatacaatga ataccactaa aacaataaaa tttaacttca 75240 ataatgaaaa cttaaagttt ttaaacattc taacttgtac ttatggtgat gatttctata 75300 atataaaata ttattattat ttaaacacaa atgaaaatac agatataaca gaacttaatg 75360 ataataatat tagtattgaa gaaataattg aaaaaatagc acatcatgta tatagatacg 75420 cacatattta tatcaatgat gatttaaaca tattattaaa agatcattta cttaaagtat 75480 taaatgaaaa taataatgaa ataataaaaa gaatacttat taaatcagga tcatttaata 75540 gtaattattg aaaaggagat atgaaatggc aagagtaaca tcaaaagatt tggcagattt 75600 tatactttat aattcagaaa aaggtattag taatttagaa ttacaagtat tattaaatct 75660 tataactata gattatgaag ataaatttgt tggaaaatta ttatctgatg aattaacaca 75720 ttttggtaga tatgtattta aaatatctga tgaagtttat tggaatttta gaaattatgg 75780 tgcaaatagt atagatagac ccaacaaagc agtagaatta aaactatcaa aaaagaaaat 75840 agattttatt attgaaagaa taaaatatta tactgaaaat ggatatttta ataatatgaa 75900 aataatacaa gaacacaata ataaagaaaa tgataagaaa aaattggcta aaacacatgt 75960 agaaacattt attaaaacag tttggttgtg tatacctata tttactttaa tagctttgct 76020 gaaatatatt tttggttaaa ttaaaggatg aataatatga ttaattgtga aattgttgga 76080 aagataaagg aattaaacaa tgaaattatc aaaaagatgt taaaagaact acatagtttt 76140 aatgtacctg tagactacaa atcttcctgc actgtttttg aggaggggac tattgcagag 76200 aaggcgaggt atcctgaaag aattgaacac gaatttggtg attttgatgt ttgggattat 76260 tatgatgatg gaatcaaaat atcccaaaat aaaatagaat tttttaaaga aggtagtcca 76320 aatggtttat caatatcaat aaaagacaaa tatttgcaaa tatcattttc actagcagat 76380 cgattagttt tcacggagca atgttacgat ttggattgtt taggaaaatt cactatatct 76440 tattcgtata atttatcgag agtagacgaa agctatatgt ctaaaagaaa aattaagaac 76500 ttaatagaaa aaaattatat tttcttcaag gaagctatag atgaatgtaa tatactttta 76560 tcaaatatgc aacaaatttt tggaaataat ttaaaaaatt aaaggagata ttaaatggtt 76620 gatgatagat tgtttcatta tataaagtta gcagagtttg cggagtttat acacaatggc 76680 aatagtcaca ttttagttat gatatttatt cttatcatta ttggcttatc attttttact 76740 gttgcaatta gtgtatcatc aaatgagaaa atatctttta atagtgttat tattgtatta 76800 tcttcattaa taacatcagc aattataatt tattattatg tatctgttcc aaaacctagt 76860 gtttattatg ctatggctta taaagaactt aaggagaata acttaacaga aaatccatca 76920 tataatgaaa tcaaatctcg tatagaaaaa tatttagagt tagaaaatga atattttaaa 76980 aagatgaaag aacaaattaa taatgatgga agagcttatt attattcaag accaagattt 77040 taataatata ttttagaaag gaatgaaatg aaaatagtaa aaaggaaaga atattttggt 77100 gacgattatt gtttagaaga aataacaata gaagatgtac tagaagctat ttttgaacaa 77160 ttaaagtttg attattttat tgaaaaaaat tgggaagtag atttagatat ttgcttagaa 77220 gagttttatt ctactgataa atttaaagtt atttttgaag atgttgaatt agaatttgat 77280 actgatatca aaaatattag cagtgaaaca attattaatt ttttaaaatc aaaaggtgtt 77340 aagtttgaga aaggaaataa acatgaatga ttctatttag gtaatggaaa aattatttca 77400 aatagaatag cattagattt gggcaagtta aataaaataa atgtattagt aggaaaagag 77460 ttaaacagta ttattaatat aatttaatgt gaaaggaata aaaaaatgaa tttactaaga 77520 aaaacaattt tattatttta tagaagagct gattactttt ttagtgctaa agtttatagt 77580 ttaaataatg aagatatttt tgaaataaat ggtaatttaa aacaccatta tttttacagt 77640 ttaaaaggta gtaatgtttt tgatggagtt tgtaaaataa tagaatcaga atatcctaaa 77700 aataaatttt attattatgt gcaaaatata agtagaataa agtagtatta agaaagttta 77760 agtttttgta tttatcgaac tttatttata attacaaaga caatataaat atatatgttt 77820 tatttaataa aatgaatcaa aaataataca aaagcttcaa ttgatgatat tgaaaaatac 77880 ataaaggata ataatctatg aagaactatg atgagataga aactttaaga agtgtggctg 77940 taataacaga ctcttcagac aaccaaaaac ttcaagagag cttaaaagaa gcaaatgaat 78000 atctagataa aatgtatgaa aagtataagg ttgaagagaa aattagagag tggtctgata 78060 gaaagggtaa aagatgaaag ttttacagtt tacattaaaa gctaaggaaa actcagattt 78120 agcattctta aatgattttt attttataat agacgataaa gataaatgga gagctattca 78180 tattactggg tcagaattca gagacagcat taattacttc ctggacgaac tgctccctag 78240 agaatgtaaa gtaattagaa ttaatgataa gaactttaat agagataaaa taatctctag 78300 tctagtaagt agattaaact cgtttatacc tatggaaact aatatagaac ttattgatga 78360 ggaactaaat agagttacta tgagccttta tagttatctt aaattttatc acaaggataa 78420 taaagttata agtaaaatac taaaaatatc tgactttaag tataaaaata gttttaataa 78480 aataaataag atggctaaga agtttgaaag aatatttgaa taaatagata aaaattattt 78540 tatattaaaa atatagggga taataaatga tgcctgaaaa aataaaagaa acttttgaaa 78600 aagttattaa acaaaagaat aaagaatata cagatgaaaa aattgcggaa ataataaaag 78660 aaagggagta catcgagcgg gttataaaag tggaacaatc acacataact ccacatatta 78720 actatgatga agatgcctta aataggttgg atcaattttc aacttcagac cttgatgagc 78780 ctactgaaga gatttcaaag ttagatattt tagaatatag aagaagaatg ttcggacaac 78840 taactgagag tgaattagaa tagttgaaat ctttctatca aactatgaaa gataaacaag 78900 actcagaaga caaggatatt gaagattttt atttaaacct agacagtaat catccacttt 78960 acataaagag cttaaaatat aagaaggtta gtaaagagaa gattgaagag atttcaaaaa 79020 gattaggaat ataatgagaa ttatattgag taagtgtata aaaggtatat ttttattaaa 79080 gacattttta aaatacttaa taaggaataa ataaagattt ttattgaaaa tagaagactt 79140 tctaacaatc tgtgtgtctt tattcattaa taaaataata gacttcttag tgttaataat 79200 attatttgga tgcttcaata tgaaaatctc gaattgaata ttgaatcaat attaataacc 79260 aaaagaattt aaataatgat aatgtttaaa tatatattaa gttaaatatt atataattat 79320 actaaattat aaatgaagga tataaaatgt acgattacga gcattttaaa aacaaagttg 79380 acattatatt aaataaatgt ggtgagaact actcagctac tatatttccg aaaaaattaa 79440 attgtgacat tatagaactt gatgaaaata tgtatgcaac ccttaaacga gtatcagtag 79500 acgaagctaa cggtgatagc gataatgatt taattttgga agttgaattc acaaacactg 79560 tgagtaatat gaagtctgtt ggaaagtttt attgctttag gttaggcaaa aagatattag 79620 ttgataactt gatggataat gaaaatgaaa gattctatat gcgttgtata agcgatatac 79680 aagattatta ataatgatat aaaaaaataa aaggagtaag aaatgaaaaa aaaaatatat 79740 atagaacttg acagaaaaga aggacaaatc aatgacattc catatgttat tttgaaagtt 79800 gaatatccta atctaaaaga attaaaagat aaggatttat taatgcaaaa tgacaaagga 79860 caatggcttt gtggctatat tggcttaaaa cacgaacaag aattagattt taataagttg 79920 aaaaatgaag tttgtatagc ccctatttat ttagaaaaat ttgacactga tttatttgaa 79980 aaagacgagg atattactaa aatcatattt tttgatcaaa atcattcttg gaataaaagt 80040 aggataaata ctcagttaga tgaagattta tgcttaaaag atattgaaaa agtagtaaat 80100 cacattatta attttaacaa aaataatata aaagaagaaa attccaataa agaatataaa 80160 tttcaaagga gaagaaaatt acaaaataga ttattataat ttttttagat gaagcagatt 80220 acttaatgaa aaatacaaag aagaacaaaa ggagcttaca gaagaagtat ttttaaattt 80280 tttaaaagaa atggtagaaa aatacaatct taataaaaga aaatattatt tttttttttt 80340 tttttttttt tttttttttg tgcttcataa taattttctc tttgtaacaa aaaacaagca 80400 atgttacaca ataatcagct ttgaaaaaaa caaagataga aaaatagatt tttcaggata 80460 tagccttgaa acaaaataac aaggacaaaa atattttgaa gaaaatttta aagaatatga 80520 gaaagttgat tttttatggt atagcaatgg agttactaaa atgaattttc aaacaatgtc 80580 caatttagct atatacgaaa ttttaatagc tttactaatt ggcgaagaaa atgaatggaa 80640 agaaaaacaa aaagaattta tgaaaaatgt tttttaaact tatgtttatt gatgatttat 80700 accaagatga aaataaatta tattttataa tattagaaga aagagaggtt tatggatggt 80760 attagtgaat atcttactaa gaaatatatt atattaagtg atgaaggttt tgaactttta 80820 attcaaaaag aatatttaaa atagtgcaaa aaagtaaaca taatgaagtt taagttttta 80880 tttaattata ttataaatgt tattataaga ttatttaaaa atatagttga agaaaatttg 80940 taaaatatat ttaaaaagga gataaaatgt atattagttg caaaatacat gttagtgata 81000 ttgaagacta cgatgaaaat gatttattag agttgtatga taatttaagt gactatgagc 81060 aagaaaagtt tttacaaaaa attacttcaa atattgaaga agctttagca aagataacaa 81120 atattttgta taatttacct tatgaccaag cttatgaaat tgtttgtaaa ctaaaagatg 81180 agtttaaaag ttttgaagaa tggcaagaaa tatcaagagg cataaacaat gagcaaaaat 81240 aaaaatatac ttattataaa tttaaaatct ataagatata ataatcaaat aaaagatttt 81300 tgtatcaaaa cttttgatac attaaaagaa agaatgaaaa ataagaatga ttttacaagt 81360 gagtttagta gcaatggtaa atttatattt aatatcaaag tttcattttt aaataattca 81420 ggaagcatag atataacaat agattataaa acaggtaaaa atgaagatat tttaaagaat 81480 ataactgact tttatctaaa tgatgaaaat acttatagct ttgtgtctat catgggagaa 81540 gatgtttctg atagatttat aagcgatatt aataatgaac agtttagtga aagtttattt 81600 aattttttat ttacatctat gatataagtt tattttaaga ataaaataat ataattatgt 81660 aaattaaaaa atatgtagtt gaaaggatac gaaatgagta tttataaaat tatttacgat 81720 gaaatattta atctttttat agaattacaa aaaagtgatg acaaattaaa aatatatgat 81780 ataataatat cataaaaaaa taaaaaggat ttacaatgga tgaaattact acttattaca 81840 aagaactttc taatgttttt gaaaaacaag tttctcaatt atcagatttt gtagaatatt 81900 taatagcaga aagtaattta aacgatatag aaagaaatga agtattaggt aagctttata 81960 gctttagaca gaaacaactt aaagaacttg ataggtttat agaaacgaag taagcaatag 82020 cttacttcaa atatttaata cttaatgtat tatgtgatga gtgataatga tcaaatatga 82080 ttatgtaata gattttataa atgatagtgg tgttactttt gattaagtta aaattaaaca 82140 gctaaagata tagaatatat aattttaaaa tattaggaga tatataaatt ggagcatctt 82200 caactgcata ttattataaa aacaaaaaaa agagttgtag aacaagcttt aacagtttca 82260 aagaaccaag caaaatggga agctgcaaga gagttctgta gaataaataa tatggaattt 82320 atggtattaa ctgaaaatga attatttaag taacctttaa gattgtttgt ggtataatac 82380 tacaaatatt tgaaaggaat aatatgaata acgcaactgt gatatctttt aaatttgaaa 82440 ctgagcaatt agcattttta aataattgca tatgttatta tgatgatgaa ttctacaatg 82500 ttaaatatat gtgtaatctt tcagatgatg aatttaaaag aattaccaac ttcataagct 82560 gtatggaaaa taatataaaa tacttagaaa taaatgataa aaatgttgat attgaaatgt 82620 taattaacag actaggtaac catatattcc gttatgcaca tactgatact ccgaaagaac 82680 ataaagacac agagtatatg ttactaaaag attatttatt actacacatt aaagactatg 82740 gtgataatga attaataaaa caagttctta aaaagtcaga agaacttaac aatgaatatt 82800 atactataaa ataatgagat taaaatgtta gaacatatta aaaacttttg tgctggagca 82860 cctatagtcg gtggtataat gttattatgt atattatttt tatactttcc ttatattatg 82920 ctaccattaa ttatagtaat actgcttata agttttagtt attatatagg acgagagtta 82980 agagataaag aaaatttata aagaattaga agaaaaagag aaaaatacta aaatgatagg 83040 agcttaaaat atgaaaagtt ttaataatac ttttaatttg aaagatgagt attacacacc 83100 aaaaatacta attgaatttt tgataccttg tttgtatgaa aagaatatta ctaaaatact 83160 ttgtcctttc gatgatgaaa cttcaaatta tgtcaaagtt ttcaaacact atggttttga 83220 tgtaatttat ggacatatta atcaaggcaa agattttttc gacaaatggt ggatagaaca 83280 cgattttgat attttaataa gtaatccacc attcagtaaa aagaatgaaa taataagatt 83340 gttgaatgat gaaaatatca attttatgct attaatgaat ttaatgagca taaattatca 83400 aaattttagt gaaacattaa gattagcaaa cttacaaaaa actataaatt tcataatacc 83460 aaataaaaaa gttagctttg atggaaatac aagtagtttt agtagtggtt atatttgtaa 83520 ttgtatagaa agtaatttgt ttattgatct accgcacaat aattcaaata aacattataa 83580 taaaggagta acaaatgaat gtaaatgtta gaataaatcc aagtgatata gagaattttg 83640 atggatatga tttagtagag ctatattctg aattatcatg tgatgaaaaa aataaatttt 83700 ttaagagaaa ttaacatgat taatattgat gatatgtcta tgtttgatcc acttgaaaaa 83760 aatacaaaat attttatata atttgccatc agatgaatct tacaaaattg tttgtaaatt 83820 aaaagaagag tttaaaagtc aagaagaatt ggaagaatta gtaaagagca taaactctta 83880 aaggtttata aatgaaaaat attttaatta taaactttac agaatcaatt agaaaagaat 83940 ttgaattaaa agacatggat tgtttagatg ttggtaattt ctttgaaaga aaatcaatag 84000 tacttccaaa gaaaaatcac gaatcagtac atattgatga tgttttattt ttattttatg 84060 aacatgattt attagaaaat gtttttgagt tatgttataa aaataacaca gataaaaaat 84120 attatttcat gggagaaaac aatgaaataa ctaagtttat acaattcttt tttagagaag 84180 gtaaagtacc gtattacata atagatgaag atgaaagaaa aatgattaca caaagtatgt 84240 tagattacac cttacaacaa ataagagaaa atagacaagt aaaagatttc tgtattaaaa 84300 actttgaaac gctaagaact agaatgaaaa ctaaaaatga ttttaagtct gaatttagta 84360 ttaatggaaa gttttatttt aatattaaaa tatcattttt aaaaaaatat ggaactattg 84420 atattacaat agactttaaa acaaataaag atgtgttaaa aaatactatt gactttcatt 84480 tgaatgatca aggaaattat agattcttat ctattttagg tgaagatgta tcagatagat 84540 ttgtaagtga tattaataat gatgaattta gtgaaagttt gtttcaattt ttatttagtt 84600 ctatgattta agtttagttt aagtacattt tttttataat tgtaaaaatt aaaatttgaa 84660 aggaaagaaa atgaacttct taaactttaa agtaaatatc caaaacatag agcacgaaac 84720 tgcaagctct gtatgtttta aaatgccgaa aaaaagcaaa tatgcaggtt ttacattttg 84780 gcttagtaaa aaattaataa aagatggaag tcattcttat gagttaagtt gtggtgttgg 84840 agaagatttt ataattaaat taaaaagaac ctctaaaaag acatttaaaa ctttaagtga 84900 atgcgaaatt actgctaaag aattagtcga gtgttttcaa taatggctaa atattttatg 84960 agaatgaata taaactttat aactgatgtt tatatccatt tattaaatgg tgcagtcttt 85020 aaaaaaagcg agtgtataga atataaaaaa tgtttttatc cactagcagg acaatttaaa 85080 gactatggtt taaaaaatga taggttatgt ataaaaaata ataaacttat gtatatacct 85140 aaaaaacttg atattaaaga gtataatgct ttaaatgaat tcattgacta aattacaaaa 85200 tttaaaacta ggtgctttgt ttatggatat aggcacagga aaaactaaga ctatattaga 85260 tatctatgca aaaaaatgca taaatcataa aatagtttat ataactccat caagtcttat 85320 taaaagcaca aaaaaagaat gtttaaaatg gtatgattat gatataaact tcttttcaag 85380 tgaaagtatt tcacaaagcg attatattta tagtgattta gttaatttta taaaagaaaa 85440 taatgtattt ttaataatag atgagagtat aaaatttaaa aatatagacg caaaaagaac 85500 agaaagactt ctaaagatat ctaatctttg cgattataga tttattttga atggaactcc 85560 tattactaga agtattttag atttattaac gcaaatgaat attttaagtc ctaaaatatt 85620 aaatatgaat gaagttcaat ttgctaaaaa tttcttagaa tatgaaatta actctaaaaa 85680 acaaaagtct tggaggattt ggagtaaacc gcataatgaa aaagctttaa tgaaaatgat 85740 tgagccttat acattatatg gcagttttga ttttgaaaat aaaattttca ttgaaaataa 85800 gatttttcat ttaaatgatg atgagttaag agaatactca ttgctaaaaa gtgagctttg 85860 taaatacgat aacattgatt tttttagtgt aagccaaaaa ttacaaagat tttacacaga 85920 atgccttgaa aaaatagaat tcttaagaaa atataataaa aaagatactt tatttttttc 85980 taagttttta ttttggcagg atattttgga aaatatattt aaaaatatag gagtgtttaa 86040 tggaaataag aaagatgatt taaataatta tgatttagct ttagttagtt atggtgcagg 86100 tgcttatgga ttaaatttgc aaaaatttaa aagaatagtt tttttagata caacttttaa 86160 ttatggtgaa aaaattcaag ctataggaag agttaaaaga aaggggcaaa ataatgatat 86220 tgaagttatt aatttagttg taaatacagg cttggaaaat attatattaa aaagccttga 86280 aaaaaagaca aaaagtgagg aaaatataag aaaaatttta aataatatga aaagagagga 86340 tatattagaa tgtttgtaag tccagtttat aatattaaaa aagtgccttt agaaaaaata 86400 gaggctaatg attataatcc taacaaagtc gcaagtaaag aaatggaatt gctttacttg 86460 tcaataaaag aagatggcta tactatgcct atagtttgct tttatgatga taaaaaggat 86520 aaatatatta ttgttgatgg atttcatagg cacatgatta tgaaattaca caaagatata 86580 tttgacagag agggtggttg tatccctgtg agtgttattg aaaaaaatat agatgataga 86640 atggcttcta ctattagaca taatagagcg agaggtaagc acgatgtaga attgcaaagt 86700 aatatagttg gaatgcttaa gcaggggtgg agtgaaaaag atataatgaa aaaacttgga 86760 atgagctacg aggaagtgca aaggctttta ggaattatgg gaattgctag tgaaattcaa 86820 ggcgtagagt atagtataga gaaacaaatt gtagaggtag gtgaagatgt caaggactgc 86880 gattaatggt agcttaaatg ttttagaagc tacaaagaaa agaatagcct atctttttga 86940 taattacgat aatattcaat taagttttag tggtggtaaa gatagcactg ttctttttca 87000 tttacttaat aatgaggctg aaaaaagaaa tagaaagttt tttgtgtatt ttcaagacca 87060 agaagcagaa tatcaaaata ctattgattt tgttgagtgg gttatgagcc aaaataatgt 87120 aataccttta tggtatcaag ttcccatttt tatgactaat gcagtaagcc acgagcaatt 87180 atttttatgg agttggggag aaaatgagca atggataaga gagaaaaatc ctttagctat 87240 acaaaaatta gataaaaaat accctaaaag attttataaa tttaatcttt gggtaaatca 87300 aaatttagca aaaatggatg gtaaaagtgt agctataata ggattaagag cagaggaaag 87360 tccagatagg agaatggtta tgtttggaga aaatagcgag ttattttggt taagaaggat 87420 taagaaacca gataaagctt atcctattat tgactggagt tatactgata tttggaaata 87480 tttaatcgaa aataaaaaac cctataataa aatttacgac aaaatgtata tgttaggtaa 87540 aaattttaga aaaatgagag taagtaattt aattcatgaa aaagcttaca aatgtttaag 87600 tgatttacaa gaattagaac ctaaaactta tgataaatta gaacaaagat taaaaggtgt 87660 gcattgtgcc gccatttatg ctaaagaaaa tttggtatat tctattaaaa atttaccttc 87720 aaagtttaaa acttggaaag aatataaaga ttttcttttg gaaactatac accctgattt 87780 gagaaaaata tttaaatatc aatggagtag atttggagat actgaagatg taggggcgtg 87840 taaatatatg gttaaaagga ttttgctttg cgattgggaa ggtaatatca cttggaacag 87900 agataacgag tttaattata ctagagagca gatactagaa aaaaataaaa ttaaaaaaac 87960 tgatgaagtt ataaaaaaat ggttttcaaa attttaattt tacttgacaa attaaaatat 88020 ctatgatatt attatataaa tttttaaaaa gaatggaaca aaaatgaaaa tggaacttaa 88080 tttaagtcaa gatgattaca gatatgttta tcaatataat gaaataccat ctaaatcttt 88140 acaaaataat ttttaatgaa gggaaataat gagccagtta ataagcaata aagatataat 88200 aaaggaaaat tttcttaatt ttcacaatga tgatactttt tatattataa aaatatttag 88260 tagaaagaaa gatgctattg ttagtaataa tgaagatatc tttaaaaatg tttttggaac 88320 tcataatgaa agattaatag caaactatta tatttcaaat gaagaagatt ttgaaaaata 88380 ttgtaaagtt tctgaacata ttgttaatag tataccatat acaagagcgt attttaatgt 88440 aaatcctaag tctaagaaaa aggctctgtt acatttacat gatagagtaa ataagttggt 88500 aactaacttt attaataatg ataatgttga tgtcggcaaa aagatccaag cattatcata 88560 tagtgtttta tcaaaaccag aagctgatca agatagaaat ttaaattggg taattttgga 88620 tgttgatgtt tacgaagata aacataaaga tagtgtcagt aataattgca ctaagattgt 88680 taatttcaca actatgttga aagcatgtaa catcaattat gtagagtata ggactgtaaa 88740 tggtcatcac tttgtgataa atcataaaga ttatggtaaa cattttatta atcctaattc 88800 tcaattatgc ggagattata aggagttcat ctctaatgat tttgtagatg agaaaaagaa 88860 ctctgctgca ttactattct ggaaaaggag ataaaatgaa actaaaagac tttgatttta 88920 gaatttggga taatattcaa aatgaatatg ttacaggtga cttggggtta tatgttatga 88980 atcaagataa tgattataaa ggtccaatac aaagaataca tgaaacaaca agatatagtt 89040 atgagccaca atgcccttca gattattgga ttgataatgc taaaaaatat gaaaaagatg 89100 ataatagtgt ccaaatagaa ttatttactg gattttatga taaaaatggt aataagattt 89160 atgaaggcga tatattattt tcttttcaag attgtcctga agaggaagct tttaaataca 89220 aagttgtttt taaagaagga agcttctatt tagttcaatg tgttaataat gatgaagaat 89280 atgttgaata tttaataagt gaattttggt tgtcaaaact agaaattatg gggaatatcc 89340 atgaaaatga agatttattg caataaggtg tattaatgga taatgataag agattttaac 89400 acaaataaca ttaattgtta aagtaatttt aagtttatta tataattata ttataaaaaa 89460 ttaaatgaga taaaatgaaa ctaagtgatt ttgattttag aatttgggat aatactgaaa 89520 agagatatct taatgaaata gaacttcata aatatgacaa atctcctgta gaagcaggaa 89580 ccacatttac tgaaactgac agaattaatg aagtagagtt tgtaaagaat aagaataatt 89640 tagagataga gttatttaca ggctactatg atgataaagg caataaaatc tatataggag 89700 atattataga atgcttagta tttactaatg aaaaaaattc agaaatattt tatgaaatta 89760 tttgttttga tatggaattt gggttatgtt ctaaattaac taatggtgaa agtggatact 89820 tatttgatct tcgtagacat aaaaataata aaacaattga agatgtatat gtcgtaggca 89880 atatacacga aaataaagat ttattgaaga tacaaaaatg aaaaacaaat tttgtaacag 89940 atattgtagc aattgttcat taagtgataa tagttattgt atgtatgata attatgaata 90000 taaatttaaa tcaaaaaaag tgttatttat attagaatgg atagttattt taatttcaat 90060 tctaggacct attatttata ttgtaattca agaattattt aattagcgag ggattaaaat 90120 gatttcaaca gtatttgaaa atgaatatgt tacagtaatg acaagaagag atgtcaatgc 90180 tatggtaaag tgttttaata agacttgtga ttgtaattgg aaagatgatg aaaattgtga 90240 tgaatgttgt agtattgacg atttatcatt taaattgaaa gataatcctg attgtaacat 90300 ttttgtaaag tttaaagatg actggagatg gagtgcaaga agatatgtta attcaatatc 90360 agagtatatt gaagaatggt tggatagtga tattgaatta gtaaaatacc aaaggaaact 90420 ttaaaatgtt tgtagataat atatcagtaa aagtaaaaaa gctaattgat catataaata 90480 tatgtataca tccttataat cctattgata aaaatgatgg agaaattaaa cagtttaaca 90540 ttcttatgag tgatattagc tatgataaaa tagaatcaaa taaaatacta ggattattta 90600 gagcaatatt agattatact agaatagaaa atgagtttgt aattatgcct tgtgaaaatg 90660 atactatggt ataataaaaa taaaacatga aaacaataaa ttattaaaac tttataataa 90720 ctcaatacta ttaactgata ttatgtgttc tgaagcaatg ttacgacatc atataagtaa 90780 tgttgtattt gatataaatg gtttattaaa aaataagtat aaaaacactt atttaaagga 90840 aacaaatgat tatgaaaagt ttaaagtagt agaaaacgca ataaatgtaa atggcttata 90900 tattcctttt gtattatcta tattaactac aaaatatttt tgtgttagcc cttacataaa 90960 taagatagag ttttatgtag atagttttaa taaacatttt accatagaag atgtaataaa 91020 tagtagtgta gaaagatttt ctaaattata tatagaacca tatattaatg caaaagggaa 91080 taatatatgt tattagtttt actgatatac tttgctgaag ttgttgataa tttaaattat 91140 ataattgatt ctatttttat aatttctatt attatttttg ctatatgcac tattataaaa 91200 atagttgatt ctgttaacaa aaaacaaaca tctattgcat ataaaaagat ttttaaaaca 91260 tctttgataa tattaacagt tgctgggtta cttcatatta tattaccatc atctaaatca 91320 atttatttaa tggtaggtgt ttatacagga aaagtaacta taaataatcc aaaaatgtct 91380 tataaactta atgaaataga taaaataata gataaaaaac tagataaagt aatcaaagaa 91440 tatgataaaa aataaattta aaaaaggagt ataatatgtt taaaaatatt tggagtaatt 91500 ttacttttat ggtaaaaagt ttttttattg ttctgtggga aagctattgt gctattgcgt 91560 atcttttgta tattttatat cttttaactg tagatactat aacaatgtat catgtatgtg 91620 ctacaatagt ttttagtact gcttttattg tagaaagatt agaaaacctt ataaaacaaa 91680 acaaagccta attttggctt tgtttattct tacttataat tttagttatt tcagctattg 91740 tcattacttc ttgtttacca ttaccttttt caacttcttt aggacttatt ttaagctgaa 91800 tatcaacaat gttcttatag atatcagtaa gtaattttgt gctattgttt attgtatcta 91860 ctaaagttga ataagtcata ataacttgat tagaactaat aggatcagca agtatattat 91920 ttgaaataac ttctaatata tctctacctc tttgtatcgt gttaactaaa gattctctca 91980 ttaaattaaa atcgtcttta agataagaga acttcaagtt ttcttctgca ttagattgta 92040 ttagatcaga cttttcaact tcaactattg ttttttctgt aacattaaaa atatcattta 92100 ttttatctaa ttttttattt aaaacttctg ctttttcttt catataaatt gtaactccat 92160 ttcataaata ttactttgca aatcaaaaga gtttatagct tgaacactta attttaaact 92220 accttgattt ttagcaaata ctgtaaaata atttaattgc ttagatataa taggttctac 92280 accactatct tctaaaacat ttattataaa cttgatatta tcatctgtgt catcattgta 92340 aattattcta tactgcatat tttgttgaat aggtaaatta gtaaatatac cttctacttt 92400 gcttatagta ggtttaactt tattccattc ttgaccgtaa tctattctaa cataagtatt 92460 tacatccata gtattagtag tgtcgtctat atcaaattta tgaactattt ctttactatc 92520 ttctgaaaaa tctacaactg gtgataaata taatttaact tgttgaatta tagcaccatt 92580 tttaataggt ggataaatat tgccatgaag tctcattgta acatttgcac tacaaactct 92640 tatatcagct ccatcatttt catcaggcaa ttcataatct acgctaatta attcaacttg 92700 tatagttgta ggttctgtta accattctaa ctctctaact cttaaattta tatttggatt 92760 aaagaaaggc aaaatttgtt ctagtataga agttaaatca gttaaagacc tagtagctat 92820 acttagtaca aaatcaaaag agtatggaac gcagttgtgt tgaaatgtta tattttttcc 92880 atctatatct tttataggta tttgaaatct acttgtagct ctttgatcat ctctttccat 92940 gctaattaat gataaagaca ttctaggtaa tatattaaaa ttaccgctca ataattgatc 93000 taattcagta tcactgaaaa cagaagctgc atctttactt ccaaaactaa taggtacagt 93060 aatatactta tctgttgttt catctatttt ctttttaact tgtatatcat taaaaatatc 93120 taacattgat tttgtatatt tttttgttgt ttcaaaaaag aaatactcca tttaaccttt 93180 ccttaataaa tattgttata taatatatta tttatattta taaggaaatt acaatttatg 93240 gatagagtta agtttttaaa tgatttagga tatgaagtta tatataatag ttcaagcaaa 93300 gatttaaaag taaaatgtaa aaatggtcat atttttaata gaacatttga ttcatttaaa 93360 aaaggtgctg tagattgtga agaatgtgta tcaaatgaaa aaataaaatt tttaaataat 93420 ttaggatatg aagttgtatc aaataagtta ggaaattatt tagaagttga atgtaaaaat 93480 ggacatattt ttaaaagacc ttataaaatg tttaaaaaag gtactcatat atgtagtatt 93540 tgtgatacag aatataaaac taattttata acagatttag gttataaaat tatatctaac 93600 aaagtaggaa gtactttaga agttgaatgc aaaaatggac atatttttaa aagacctttt 93660 tttgagttta agcaaggaaa tgtaaattgt ataaaatgtg aatacgataa aagatttaat 93720 tatataaaaa gtttgggtta taaagtagtt tcattaaaaa atactaataa tataatatta 93780 gaatgtaaaa atggtcatgt tataaaaaat acttatgcta atatattaaa aactaattat 93840 tattgtgctg aatgttctaa aaatgataaa actaaattta tacaaaataa aggctatgaa 93900 attgtttcat tagaactaga tttaattaaa tgtcctaaag ggcatatttt taaaagaaga 93960 tataacgaac ttaaaaaagg tgcaatatct tgtcctgaat gtttaaaaga gtataaaata 94020 agttttatag aaaatattgg atataaaata gtttctgata atttatcatc agaactagaa 94080 gtaaaatgca aaaatggaca tgtatttaaa aaaccttatg aaagttttaa aaaaggaata 94140 aggttttgcc aagcttgtgt taatgaagaa aaagaaaaat atttaaataa gataaactta 94200 aatatagtat ctgatacatt aggtggagat ttagaagtaa aatgtgaaaa aggtcatgtg 94260 tttaaaagac cttatgcaat atttaaaaga ggacatatct tatgtcctac atgttatcca 94320 aatacaagtt catttgaaaa agaagttgaa aactttttaa atgtaaaata tattaaaaac 94380 aatagaacaa ttttaaatgg gaaagaactt gacttttata tacctgaaca taagttagct 94440 atagaatgta atggagatta ttatcattct gaagaaaaag gaaaagatag aaattatcat 94500 ttaaacaaaa cacaagaatg tttagaaaaa ggaatacacc ttatacatat ttttgaatca 94560 tcttggaacg agaaaaaaga tatttggaaa tctattatta ataataaatt aggcaaatct 94620 aataaaataa tggctagaaa atgtatttta aaagaagtta gtaatgaaga agaaaaagag 94680 tttttagaag aaaaccattt acaaggattt ataggatcaa gaatttgtta tggactttat 94740 tataataatg aattagtttg tttaatgagt tttggtaagt caagatttaa taaaaaatat 94800 gattttgagt tgcttagact atgtacaaag aaaaatataa atgttatagg tggagcttct 94860 aaacttctta ataattttca taaaaataat aaaagttctt taataagtta ttcagataga 94920 ctttactctg atggatcaat ttataaacaa ttaggattta cttttagtca ttattctaaa 94980 cctggttatt tttattttaa aaatggaatt agatattcaa gacaacaatt tatgaaacat 95040 aaactaaaag ataaattaga aaaatttgat ccaacactta cagaatatga aaatatggtt 95100 ttaaatggat attataaagt ttttgattgt gggcaaggtg tttgggtaaa agattaagaa 95160 tctaaatacc caaaaatact atcagttcct ttaactaaag ggctttcttt gtcttgttct 95220 tcttttattt tatcttttga gttttcaaca ctaccaacta aattaaatat ttcatctaaa 95280 gattcagtac tttcttgatt atcaacttgt tctaaagttg gtatgttatc atgattataa 95340 ctaaatgact tgcatcttaa catataaaca ttttttgagt ttgaataaac aaattgatta 95400 ttagcaccag gtacttgatg ttctatactt gttatttcaa tatattttcc actcggaagt 95460 aatagtatat cacctacagc agaaggcata tcagattcat tttcaaaaac tcttttcatg 95520 ctattagcac taacaaaaag attcatagaa tccatagtaa atataccaaa tttatttaat 95580 atatcacctc tttcttcaaa catttctgca ttttcaggta aagcaaatat tttaaaaaca 95640 gaatctgttc cataatttac tatatcatct aaaactttgt catgacctaa tctagtagtt 95700 tttatatagg ttaattcaaa accatacata tctattactt ctgctgatag agtaccaaat 95760 aattgatact cattatgttt attgtttaag ttccaaccca taatttacct attgaatttc 95820 aatacaacgt aagaataaag attgaccgtc gtttgtgtta tctaatggat gttgaactac 95880 atcatatctt acaaaatgaa aataagtttc agcacctgtt tcagggtcaa atgctttgct 95940 tatgttataa ttatagaaag caaaacaagt tgatccatcg cttacttcta cttctttatc 96000 tctgtgttta taagttatta acatatattc tttttgcaaa gcattgtaat aatcacagta 96060 tatttcagtt gcacctattg aacccataaa ataagaattt gtaaagtctt cattagcttt 96120 gaaattagga tgtgacatta attttgcaca agtatcataa ggtgctgtaa tacacattgt 96180 aatagctctt tttgttgaag cagccatttc taatattttt gcttgagctg cattatataa 96240 ttctataccc actaaaggat catttggagc ttttaaagtt aattgtgttt ttgttgcttt 96300 ggttgtcatc attaataaag actcgtggtc tatttcttgt attatttcag ttaataattc 96360 tttttctaat atatcactag cagtagttcc acctgtgaga gtaactaaat cagtaagagc 96420 ttctaaagac cattttgatt ttattttttt agtttgacac tcaatttttc ttcttattac 96480 ttcatgtttt gcttcagagt taactactgt ttcttgattg tttaatctat tgcctccgaa 96540 atcaggtata actgtagaat aaggggtatt gcttttatct acaccttgat aatcttttaa 96600 ataacttgtt ttaaatgcaa aaatataacc atttggagct tgtatgttta ttctagcacc 96660 aattctattc aataaagatt ctgtatatat acgatacatt aattttgaaa gttttaactc 96720 aactccagca atatcaactg ttgtagttga ttcgtttata atattactca tatctttcct 96780 ttttagtatt atttataaaa aatctataat tatatcattt aaaacttaat ttaaacttat 96840 tttaaattaa tttgtggtat aatacaaata aaaaaaggat taaaatggaa tacttaaaag 96900 aagaagattt aagaaatgaa ataataaaat tacaaaaagt tgaaagatta aaaacccttt 96960 taagtttaga aaaaaaatca gatgaagatt taaatgaaat acaaaaatta agagaagaag 97020 gaatatcaga acattataaa aaaactaaat ttggtgaaat gtgtttgtta ttaataaaga 97080 aaatattaac tatgcctaaa tttagtggtt atacatacaa agatgatttt tattctaatg 97140 ccatagaaaa gttaatgtta tatgttatac caaattatga tgctaataaa gtatctaaaa 97200 tatcaaaaca aaatgtaaaa gtatttgcat attgcactca aataataatg aatgctattt 97260 tacaagtaat aaatgaaaga aaaatagaac aagacttact aaaaaactat tattatgact 97320 attcagatat tgaaaataaa caccaagaaa aaggttcaag atgtccttat gcagaagatg 97380 ataaacctat agaatacgat gtaaatgctt atgctatatt gtatagtgat aatgaatggt 97440 ataaagttat ttcttctaat aaaaaagaac attttgattg caatttagat caaaataaaa 97500 gatatttttt agtaaatgat gttataattg aatcagatac attatgggat attttaaaag 97560 atatagaacc aaataaaaaa gtaaaattag tgtatcatca tgattattta ctaaaaacta 97620 acgaatataa taaaattatt gctaaaaatt ttaaaatttt agatataata aaatttagaa 97680 acaattatgt tcctagtttt cctaaaaagg aaaagaaaaa tattgaaagg gtgttagata 97740 tatgggaaag ctaatagctt taatgggtga tttacatttt ggatgcaaga actttgatca 97800 tgaaatactt gaagtacaat taaattcttt agaaaagtat agagatactt taaaagaaaa 97860 aggttgtaat actatatatc aattaggaga tatgtttgat aatagaaaac taattgattt 97920 aaaggttttg tatactttat caataaggtt taaagaaata tttaaagact ttgaatttta 97980 tacatttgct ggaaatcatg atatgtataa tagagataac agagatattg tttcaagtga 98040 gttatttact gacttacttg gaataaaata cataaaaaat cctacatatc atatgtttgg 98100 taattataaa ataggtatat ctccatggtt atgtggaaat gaagaactgc taaaagattg 98160 tgatatatta ttaggtcata ctgaacttaa agggtttaag tataattata ctaattttga 98220 tgaaaatgga aaagaacttg atgtaaatag ttataaaaaa gtttacatgg ggcattatca 98280 ttttaatcaa aataatgtgt atataggaac accttatcaa atgactttta atgaaattaa 98340 ctctattcct ggtattattt tattgaatga aaacctagaa gaagagttta tagaaaatac 98400 ttgggataga agatatttta tagttaaaat ttataaagat agagttattc ttcaatacaa 98460 agatgaagat gaagttttta aaggaaactt acctgaattt tgtaaagtag gaaaaattat 98520 acttgaagaa aaaaatgaaa aagaagataa gattatagaa tatttttctg ctagatcaaa 98580 aataattaaa atattttata agtatgaaga agataaatta tatgaatcta tagatttaaa 98640 taattctgta gcagagtctt tagactttat aaaagagttc ataataaaag aacattcaca 98700 tttagcacct gtgttgaatg atattataaa taattaagtt aaaattaaca atgatgtgat 98760 ataatcatat atcatttatt ttaaaacaaa ggataaaaaa tgataatgca agttagtaaa 98820 agtatgttcc aagaaggaat gcaaaaacaa ggtatgggtt atggtgcagc agaagttttg 98880 tttgattata ttgaacaatt agaagatgaa atgggagaac aaattgattt cgatcctatt 98940 gctatagttt cagagtttga agtagctgaa ggtgatgatg aacttaaaga tgtattagaa 99000 gataaaggtt atcttgaaaa cgatgaagaa gatgaagctg atttagatga tgttaaacaa 99060 agagctatgg acgatggtgt catagtttat gaagactctg attattatgt aattagaaaa 99120 atgtaaaagg attatatatg aaagttaaat taacaaaaga ttattttgta aaaaatattg 99180 gtggtaattt tgatgaagac actgcttcta ttttatttaa ctattttgaa aaaacagaaa 99240 aaaatgttag tgaacctata gaaatagata tgtatgatgt aagaaaatat tttaaagttg 99300 ttcctaatat tgaagtagaa ccaattctta taaaaaatga ttatttaagc tcaaaagata 99360 aaaatgatag taaatctgtt gataaagcca taagctctgc taaaaaagat aattttatag 99420 tatatgaaaa caataaatat actatttttt attatggtta attaaaggag tataaaaatg 99480 tatattgatg taagttatat tgaaatggta tctgaattaa aaaaacataa tttaagtctt 99540 aaagaatctg aaatgttagc tacattttat gaatggtatg aaaaaaatta tatagaagat 99600 atagatgaac ttcttacttt taaagatata gctgataatt tttacgcaac agatgataaa 99660 gatgagttta taagtatatt agatgacaat aaatttatac aatacgatgg tgatgaaata 99720 gattttgagt tttctttaga aaaagctatt gcgaatggag tagtagttta caataatgat 99780 gatttttggg tgctagataa gcaactaatg taaaagtata aatgagtgat ttactttcac 99840 tcatttatat tgtgtttgaa aggaaaagaa ttgaataata ttatatttaa aaatataact 99900 ctacaaaatt ttatgaaata tggaaataaa aaaacaaagt ttgaatttac taatggtata 99960 cacttagtaa caggcaaaaa tggtgcagga aaatcaagtt tatttttagc tttacattat 100020 tgcctttttg gaaaaacata taacggtaag acaatagggt cacttgttaa taatataaac 100080 aaaaaaggaa tgtgtgttga agttgaaatg aatatcaatg gagatgattt tttaataaaa 100140 agaggaacta cacctagtgt ttttgaaata tataaaaata atgaattaat accattatta 100200 agtacaaatt cagcatatca agaattttta gaaaataata tattaaaatt tacagaacaa 100260 gcttttagaa atcttatata tttaggtgga gatctattaa gccaatcatt tgtaagatta 100320 tcaaaaaaag aaaaagaaga tgtatttgca atactttctg acacagcaac ttttttagaa 100380 ctaacagaaa aaataaaact tttaaaaaaa gaaaaaacta ctatacaaac aaatacttta 100440 tttaaaataa acactttgca agatgttata tcaaaattaa aaataaaata tgagtataat 100500 ttaaaagctt ataatgatta tatagaaaac aaaaataata atataagtga tatagaaaat 100560 aaaatcaaag aagaaactaa aaaaattgaa aagttaaaaa aactaaaaaa acaatatgat 100620 gatatattaa ctcaagatgt tacagatgaa ataaacaatt taacaaaaat aataaatgaa 100680 caaaaaacta ctttacagtt aatggaaaaa tataaaatgt gtaaaggatg tgaaaaacta 100740 aaacaaatta taccaaatga tatagatttt tctaatcatg attatttgtt aaaacaatta 100800 gaagagttac aaaataaaaa taaagagttt ataacaaaaa aagatagcat atatacaaaa 100860 atgctagagt taaaaccatc tatagaaaat aaaaaaatat acgaagatat gctggataaa 100920 agtaaaatag aacatataga aaaaccttct tatgaagata tcatatataa tgaaaaacaa 100980 ttaaaagaag tgaatgatga gtatagtgaa ataaacaatt atatttcaaa tctaaatcag 101040 cttgaagttt tattaaacaa taataattta aaaggtgctt ttttaaatat gcacttacct 101100 tttataaaca aaactataaa caaatatatt aatatgtttg atgagtttaa ttttacattt 101160 tctttagatt caaatttaaa agaaactatt acaaaagata ataaaccatt tgaatataaa 101220 tctatgagta atggagaagc attaagatta acattttcta taatgttagc atttttagat 101280 atatgtagaa acaagtttga tgttaaatgt aatttactta tacttgatga agttttagat 101340 agtgctttgg ataatgtagg taaaaatgag ttattaagaa tattaactca aacttctgat 101400 ttaatgagta tgtatattat aagtcataac agtgatataa aaaatcaatt agattatttt 101460 atatctacca tagatattgt taatgattgc aagttctctg aaataaaata taaataaatt 101520 aaaaaggaat attaatggca tatggaattg ataacttata tacatttgtc gatgatactc 101580 aaacaggtat agataaggtt caagttaata aacctatttt attaaaaagc acaaatgaaa 101640 tttatgtaaa aaagaaagaa ggatctttaa caggaacatc aacattagct gatgctataa 101700 aaagtggtga tgtttctaat ttaaattatt ctaaactatt aacacaaaac ttagaatgga 101760 cagtaggaac tggaggtaaa ttttcagaca taaactctgc tattatagaa gctaataaat 101820 atatacccat aaatgatgta aatactataa caattaaaat agctgatggt tttgtgataa 101880 gtgagcaaat aaaacctata gttaatccta ggttaaatgt ttttttaaca tctgaaaaca 101940 gaaatgttaa tgtagattgt agaactttta ctgtaaatct agataatgct atagcacttt 102000 ttgaaggaat taccagtatt aatctattta atattaaact aacattattg cattttaata 102060 caaaaacaaa tttatatgca gtattcggtg gaggagctcc ttctatatgg cataaaggtt 102120 gtgagtttgt agattttaat atactttatg aagggggtgc tagaaatatt agttcaaatt 102180 gcacttttta ctacactaag tttgtaatta atcaaaataa aaaagataca tatattttta 102240 gacctattgg gataaatatg tatttaacaa tatggggagg gacatttgaa ttatctgatg 102300 taaaagtcca atttaccatg actgaaaatg gttctactat attatcaaga ctaaatccta 102360 ctgtaaacaa caataatact caaagtaact gtgggttgta aaagatggag gtgttataaa 102420 tttagagtat gacatatcgc ctagttctac attcaatgga acaaaactat ctcaacctaa 102480 aaatcaattg actgctaatg gctatattgt cggcaaataa gataaggaaa taaaatgtat 102540 ataagcaaaa aatttttaag tgatatagga agtttaaata aaaatgcaat tagttgggct 102600 attgaagtta aaactcaatt agctttaatt gatagaactt taaatgtaaa tgaggacggt 102660 gatgttatag acgacattac acctgaagaa attcaagcag gaacacaagc agttaaagaa 102720 tactgcttag ctaataacga gctagaatta cttaagcaat acctaccatt agttttaagt 102780 ggtgctgagc ttttaaccga aatgaaagcg gttaaactaa ttgaaattaa caaagattat 102840 gaaagtgcta ttttaaaagt tcaaaaagat tatatcccac aatctgaaat gttaagcttt 102900 gaaacacagg gaaaagaaag ccttgcttac aaaaattcaa actataaaga tactagctta 102960 tgtccattta tgcaagcaat agcaactgct aggggtattg atttaagaac gctttgtgat 103020 aaagcaatag aaaaagctac attatataga caagcaagcg gtgctttaat aggcaaaaga 103080 caaggtttgc aagatagaac agaacaaaca caaagcttag aagatttaaa tttaatagga 103140 tgggatatac aacaagcatc aactttatca acagatagtg caggtaaatc aagtacaact 103200 aaaaccacta aaacaactac taaataggct ataagttatg aaagtttcag ataggttaaa 103260 atactttttc tttatcttta gatggttttt aataggaaag tatcattgtc atatcccaca 103320 atcatacaag aaatattata aaattataca cagaatatta tggttaaaca ttttattctg 103380 tgtaatttat acatggtgta agttagttgt attgtgatga tttatttatt agaattaagt 103440 cctttattca ttgttggtat aatttgcgga ttatcaaatt atttgtcaga tgaagaagat 103500 aactgtgcag acaaaaaaat aaaatgtata tttaaataca ttattaatag tgctgtgtta 103560 tgtacaataa tttattgtat attaacttca ttagatttag cttatctaac aaaagtaggt 103620 atatcagcag ctataacata tttaggaata gacaaggctt taagtcttat aaaagaattt 103680 atacacttaa gaagatgatt atatgatttt catataatca aaattaagtg ttatatctaa 103740 agttattata ttattatcag ttgtagagta ttctaattca ctaatttcat ctagtttact 103800 tttataaaac tctactttaa acaaataatt atttttagaa tcgtatattt caagccaaga 103860 agtagcctca gctccacatc ctgtatttgt agacacttta ttatatttat taattaaatt 103920 tacaaagttc ttccatacat ttaattcttc atctactaac aatgttaaag ttattgaatc 103980 aaactttgca acttctccac ctagtgttaa agtacctgtt gaatgaccta ctttttgacc 104040 ttctaaagat attctaggta atttaacttt ttggcaaaaa tattgtacat catcagaaaa 104100 taatagtgtt ctaaaaacta tattagaatt aagagctaaa tttctataat tcatattata 104160 caccttttta aattatttat ttaatagtaa attaagctaa atatgataga atacaaaaaa 104220 ttaatttttt aaaaaggaaa aatatgttta acattgaaaa agtttttgag tttgtaaatt 104280 ataattcaaa aaatggtatt tgggaacacg atacagatta ttcatctaat gataaagaag 104340 tatttttatc atacttttct aatgatagtg ataattatga tgtttatatt gtgttagaaa 104400 atacaaacga ctttttaaat tttgaaaaat gtattatgaa agtagattta aataagatag 104460 aaataaaatc tattgaagac cttgaaaaaa atataaaaaa atatagattg taattaattt 104520 taatttaaga aacttttgat atgattatat tatcaaaagt ttaaatatga aaggaaagaa 104580 aatgaaaaaa gttttattaa gtgcagctat gattgcaggg ttaatgtttg taggttgttc 104640 aactactact ccacaacaac aatttgctaa acctatgtta gaaaagcata atgatttacc 104700 tagttgggtt gtagaagatg atgatatttt atcagcagta ggttcagcat tgtatatagg 104760 tcaaagttat agtcagcaaa gaacagaagc tattgcagta gctaaaatga atttgtcaca 104820 aaaactatct tcaaaagtag atagtatgat taagcaatat tatcaaaata aaggtatagt 104880 aaaaagtaac aatagtcagg tttcagttca agttagttca gcattactac aaaatacaaa 104940 agttgtagat acttatgttt cagatgatgg agagttattt gtaaaaattg aagcttatca 105000 cacaaactta ctagaaatta taaaaaatga tgatagcgaa gctttgttta atgaattaga 105060 tttaagagtt ggaaatgctc aatcctatta atgtaaaata ctgggaaata attcataaaa 105120 aagaagattt aggtactaat aaatctgatg attataactg caaatgtgat gtttgtggag 105180 attcaaaaaa caaaaataaa aaaagacttc atctgtatag aaaagaaagt tatacagatg 105240 attctataaa atgctttaac tgtggttaca cagctacaat gtattcttat ataaaaacat 105300 atcatacaat ttattttaac gactatttaa atgaaatagg agaaaaatat gtaaatgatt 105360 taaatataca aaatatcaca acaataaaaa aacaaagtga aaaaccaaaa gatttttttg 105420 atataaactt acctaaagcc attgaaaatg aagaagcaaa aaaatatatt ttaaaaagag 105480 gtggaaatcc taatgatttt tatttttgtg agaatagttt taaaataaaa gataaaacat 105540 ttaaactacc aaattttata atatatttaa acaaaataaa tgataatgct tttagttttt 105600 atagtcgtag tataaaagat aaaacatttt acatatttaa ttcagatgat ggtattaaag 105660 taatgaatta ttttaatata gataaatcaa aagaagttta tgtatttgaa ggtttatttg 105720 atatgctatg tactccattt gaaaacaaaa tagctatgtt gggtgcaact ttaccaaaag 105780 aattaaaaag tttaacttat attatatggt gttgcgataa tgatagcaca ggtagaaatg 105840 aaatgttaaa acatacttct aatccaaatc ataaatttgt tgtatggtgt gatgatgaag 105900 aatttaaaaa gtacaaagat ataaatgaaa tttatcaaag cggagttaat attgaaaaat 105960 ttataaaaga acacactttt gatggattaa ttgctgaatg taaattaagg atgtggtaaa 106020 actcatcctt attattttta acacactcat atcttaacaa aaacacacat taaacctatt 106080 taaattaaaa actaatacta acacatatat tcaattatat ttttatttta aacacaatta 106140 tattactttt aaagatatat attttttata caaaaaaaaa ttactacaaa caaaagttaa 106200 aatttaaaca ccgcacttaa gaaagaaact aaaatttaaa atttaaaaat caaaaaaaaa 106260 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaataaa atatattata 106320 taagtaagaa aaaaattttt ttaaaatttt ttttgtaaaa tttttatttt attttttaga 106380 aaaaaatttg taataaataa aataaaaagg ttttatatga gaaatgtaag taaagattta 106440 attactatat acagaaatgg agatagtttt gaattatata atgattttta ttttgttttt 106500 gattttgatg taacaagtat aggatttaat ttagaaaatt atttagtaga taataatatt 106560 attagagttc ctaaagggtt tgtaacagat tttggtagtg ttcctaaaat atatcaatca 106620 ataatttctc ctataggaaa atctactaag gcatatgttg tacacgattt tttatgtggt 106680 agatcaaatc aaggatttat tcctagagct ttagctgatg aattgttttt agaagctatg 106740 agaatactta atgttagtaa aattgaaaga tatcttgtat gggcttgggt aagattatat 106800 gctatagtgt ataaacctat tgctgatatg tttaaataat aggatattaa atgaaattta 106860 ttgaatgtat ggaaatatta ttagaaaaca gcgatacaat atgttctttg tctttggaaa 106920 atgattatat taaaatttat aaagatgctg atagtattaa aatattaaat tcaaaagatg 106980 aagatgtttt acttagttct gaagatatta ataatgaaaa ctgggaaatt gataataaat 107040 tatttcaagt aatattagga tctacatgga taaacaatga tgatattata acaagagttg 107100 aaaacaattc tttttacgat aatattcaat atactacttt taaaaatttg caaacaaatg 107160 aaataagtat tttagaatca aatatttatt acgaccaata ctgcactagc aaatggatag 107220 aaccacaacc tctttaagca ttatttaata acatatttta taaaataaca tttaaaatat 107280 gttattaaag gttattaaaa tgttatatga atatgttttt gaacataact ttaaactata 107340 cgctagattg tttgatgaaa cgactaaaaa gtctataaca agagaatata aatcaaatga 107400 gtatgttcct gatatcttta taagaacaga acatgaaaca cattataaag atttttacac 107460 tcatggttat ttaaaaaaga aatcttttaa agcaacttat gaagtgtttc aatatttaaa 107520 aaatgtttct ccatctactc cattatatgg aaacttaagt agaactcaaa aatatataag 107580 agaaaacttt aaggatatag attgtaatca cgagtttaga actcaatata ttgatattga 107640 aacaagagca gtaaatggtt atgcaaaacc atcaaatcct acagaagaag tttctttgat 107700 acaagtttat gataactatt taaataagtt tattattttt ggtactaaag atttaacaat 107760 agatataaaa tctgatatag gagaagttat atacaaaaag tttgataacg aaatacatat 107820 gttaaaaaat tacctaatgt ttgttaataa aactaatcct actataattg cagggtttaa 107880 ctctaaccta ttcgacttac cttatcttgt aaacaggatg ataaatcttg gtatagatga 107940 ttatgttgat ttatctccta taaaagaaat aacacataaa agaatgataa gtaacgatgg 108000 tatagaatat gatggtgtaa aaatagaagg tttaatacag ctagacttaa gagatttata 108060 tataaagtat gcaactcaaa aacctagtag atattctttg gaagaaatat caaaaataga 108120 attaaatgat aataaagtac attacgaagg ttcaatagaa gacttatata aagattttaa 108180 taaatttgtt tcttatggtt taaaggatgt tgagttaact attagactcg aagaaaaact 108240 taaattatta aaagtatgtc agatgatagc ttacaaatgt ggagtaaacg cagatgaagt 108300 ttcaggcact gttatgcaat gggcttcgct tatgtataac catgctatat caaaaaatat 108360 tatattacct ttaaaacaat taaaaataat aaactataaa cctccttttc ctggtggttg 108420 ggttaaagta agtcctggtc ttcataaaaa tgtatgttct tatgacttta cttcacttta 108480 tccaaatatt ataatagagt ttaaaatagg attagataac tatatacctg aaaataatat 108540 tccttataac aaagcaaaac aactagaact aaatagagca aagtttatga atgaagaacc 108600 taatgaagtt atatctacag cattacctaa agaacttaga gatatgctag acaaatattt 108660 ttatttgtat agccaaagtt atgataaaaa agataatgat agtatggaag agtttttata 108720 ttttaaaaac cttgttaaaa atagaaacga aataaaaaca atatgtaaaa aatatggagt 108780 aaatgtaact ccaaatggtt gtttattctt ttctgatgga aattctttat tttctgaact 108840 catagaaagt ttctttaaag aaagattaaa acataaaaag tttttaaaag atgatagttt 108900 atcttcattc gatatagatt accatgacct tatgcagtat atgtataaga ttcttatgaa 108960 ctctgcttat ggtactactg ctttagaagt aaatccattt agttttggag agaaaatgag 109020 tgaagctatt acaacttgtg gaagattttt taatatgtgg gtatcatttt atgtaaatta 109080 ttattgtaat aaaaaatata atttaaatct taatcttgat caaagacctt taagtattca 109140 atgtgatact gattctaatt attttgagtt ttattttata gatgctccta aggatataaa 109200 agaaaatgca atattcttaa aaaaatattg tgaagaaact atatctcctg ttattgaaaa 109260 tgcaataaca caagcagtaa caactttaaa tggtttagat tataatacaa acttagcaat 109320 ggaacaagaa acgatatgtg atagtttttt aagttgtgtt agaaaaagat atgttggtag 109380 atactataat gttaaaaaag attctaagtc ttataagata acaggtttac ctatggtaga 109440 tagaagtaca ccaaaatggg ttaaaggaaa gttaaatgaa tgtttagatt taatattaga 109500 taatgataca gtaggtttag ctagttttat acaaaaatgt aaagaagagt ttaaagagca 109560 agatattacc gatatagttg taaataaaag tgtaagtagt ttatcttaca ttgttactaa 109620 tggaaaatgg gtttcatcca taaatggtaa tgcttgccct ttgcaatcaa gaggatctat 109680 aaattataat aatttatgtg ataaatacaa gctaaaaaag attatggatg gagaaaaagt 109740 ttttataatt tatcttaaaa cccctaataa cataacaggt gataatgtca tatgtattcc 109800 tgattcagat agtttaaacg ctatacctaa tttaaaaaac tttgtagatt atgatacatt 109860 gtttgaaaaa aactttattc aaaaacttga tacaatgaca tctaagatag gttatgattg 109920 ttataataaa ttttcaaatt ctttagatga ctggttttaa cttgtattta agttaaaact 109980 tgttattatt aaagattaat attattttaa aggataacta atggaaatga gtgtgtattt 110040 atttgaaata tctattcctg ttattatact tattatatta atatatttaa atacttcaat 110100 gtattttaaa aacttaaaga aaggaaaaaa gtaaatgttt gaaaatggtt ttattgaggt 110160 tttaagcaga gaaacagctg aaaatataag tttgaaatat aactactacg atttaaaaga 110220 aaagctatat gagaatgaat cttgtaatgt ttttgtaaga tacaaatttt taacaaatag 110280 atgggaggca aaagatcatg aaaatttaaa tgattattta aatagcaaag aatatgaaaa 110340 tgatattaaa aatttaaatg aaaggttaaa atatgaaaat gtttaaaaga ttagaaaatt 110400 ggttaaaaga aagaaactta gatacaaaaa aatatgatca tctaacttta cttggatatt 110460 tacatgaaga aatagatgaa ggtatcaaaa aaagagatat agaacatgaa agtgtagatt 110520 ggagaactga ttgtattgtt tttttaatta acagtttata tcaagatgga tacaacccag 110580 aaatatgtat ggatgagtgt ttaaaagaaa ttgaagaaag aacaggtgag tattctaatg 110640 aaaaaagaaa atttataaaa cacgaagggt attataccaa agaagaagca gttgataaat 110700 tgtatgaaaa gtataaatgt gataaagaca gtattaaact aacatcagaa gatgataagt 110760 tttggtattt tagtgtaaac aatgaaacat taaaaataaa aaaatggtat aaggctaatt 110820 tttttaaagc tttaagaaat gatattaaca ataaagaata tattgttaaa tgctataaat 110880 ttggtaaaac catagcattt agagagttaa acacaaataa tgaatggcaa gtattaacaa 110940 attcagattt tgattttaaa aaatttgaat atatgcttat tgattaagtt ttatttaagt 111000 atattttgat aagattataa aacatattta tttaaaggag agaacatgaa cgaatttgaa 111060 aactttggtg ataccaaaaa ggtaaacatt gccgattata ttgaaaagaa tacagtagat 111120 aaatcggata tgattaagga tacaatctta aagattttcc gtttggaaaa acaaaaaaga 111180 gagataaata gtcaaataaa agagataaaa gacaatttat ctgatcatgg tataaataaa 111240 agtgatttta ctaaaacatt gtcagttttg agaaaagaac taaaaatgtc agcagatcag 111300 attattagca atgctaaaat gtataatgtt gttgctacag atgaagaact tttacataaa 111360 ctgaaacaag aactaattga ttaaaaaggt taactaaatg aagtatagat attcttattc 111420 aaagatagag tgttttagac aatgtaaact aaagtttaaa tactcttata ttgataaaat 111480 atctatacca aaagatcaaa ctgcacttat taaaggaagt tatatacatt ggttaataga 111540 acaaagtttt aaagaagaat ctattgaagt aagtaaatct tatgataatc ctttaataaa 111600 tgcagaacaa tacgaagaat ataataatat ttttgaaaaa tttaaaaact cagaaaaata 111660 taaaaatata aaagaactac catctttagg taatgaagta aattgggctt tagatagtaa 111720 attaaatcct acaagttatt atggtaatga ttatgttata agaggtacta ttgattacct 111780 tgcaataaaa aataattgtg ttattataat agattggaaa acaggaaaaa caaaagataa 111840 acaatatata cctgatgcaa atcaattagc attatattca atttgggctg aaaaggtttt 111900 taaagctgat aaaataatat gtcaatttgt ttatgttgaa agtggagatt atcatactta 111960 cacatataca aaagatgatt taatacctat aaaaaaatta tttgctgaag atataaaaag 112020 tattgaaaat gaaaaagcat ttatagcaaa acctagtgta ttatgtaatt ggtgtgattt 112080 taaatcaatg tgtgatagtt ttaaaaatag ctcttacaat aaatgtaatt agttataaat 112140 attgtataag ataataaact aaaatttata aaggataaat aatggctaaa gtttataaaa 112200 ctacagaaga tatagttaat gccattaatt ataatgttat agatatgaag aaaaaagtta 112260 attttaaact agatgataat cttgcagatg aattaaatta tcaaaaagat ggcgaagacg 112320 ctcttgctaa tttcattgta aatgatgttt atgatggtga ttctagtgtt gcagataaca 112380 tacctgaaat tgtgtatgaa tatgcaggtt ctacttcatt agttgctaat ccagaaggaa 112440 aaagttttta tgagtttaaa atcagtggca atatatttac cataattttt atgaatgaat 112500 actatgatga ttttgaagac gatttagaaa aatatattgg ttaataatta taaaggaagt 112560 ttatgcttcc tttaatttaa tattatttta agttataatt tttttacaat agtttaaaat 112620 agtagtaaag gatattaatt tatatgaaaa attacaattg tgatgataat tatttaatta 112680 aaggtgataa cctagaaata atgaaagaat tattaccttt ttataaatgt aaagtaaaat 112740 taatttatat tgatccacct tataacacag gaaataaaca ttttgcatac aatgataatt 112800 ttgcatcttt acagttaata atgaaatatt ttaatgttga tgaaaaagaa gctaaacaaa 112860 ttaaaagaaa agataaattt ataggttcta aagtttggtt aaagtttatg agagaaagac 112920 ttgaagtagc tagggaattt ttaagagatg atggtgtgat ttttgtgcaa tgtgatgata 112980 atgaacaagc atatttaaaa gtacttatgg atgagatttt tggaagagat aattttgtaa 113040 atagtatagc tgttaaatta aaaaatattg caggagcaag tggaggagga gaagataaaa 113100 gatttaagaa aaatatagag tatattttaa tttatggtaa aagttatgaa aaattagaac 113160 aatttaaatc tgtatatgat tctagagaat tgtattctca tataagtttt tgtaaagaaa 113220 ataatattag ttggaaatat acttcggctc tactcaatgg cggtgaaaaa aagttaatag 113280 ctacaacact tgatggtgat ggcaatgaaa ttaaaatttt tgaaagaatt aattatgata 113340 taaaatccat aggacaaatg ataaaagatt ttaaaatgaa tgagaaagaa attttttatc 113400 attatgtaaa taaaattttt agaaccacga tgccacaaag ttcaattaga gtgagagttc 113460 ttgaaaaatt aaaagaatta aatttaagtc cttatcttat atctatagaa tataccccaa 113520 aaagtggaag aaataaaggt gttgtatacg agcaatttta taatggagaa aaattaaatt 113580 tattcgcatg gctaaaagat gttgtagaaa ttaaagataa gcaaattttt aaaaaagaat 113640 tagctggaac tttatgggat tttgctttcg caatgacaaa tttaacaaaa gaaggggata 113700 ctcaatttag caatgcaaaa aaacccgaag ctctactcca aagaataatt gaaatttcca 113760 caaacgaaaa cgacatagta atggactttt ttgcaggaag tggcactact ctagccgttg 113820 ctcataaaat gaaacgcaaa tggataggca tagaacaaat ggattatata gaaactatca 113880 caaaagaaag actcaaaaaa gtcatagaag gcgagcaagg tggtatcagc aaagcaataa 113940 attggcaagg tggtggaaat tttgtttatg tagatagaag taaggacaat aatgatacta 114000 acatttgatc catattatga tattaaagaa agtaataagt ttataaaaaa cttaaaagaa 114060 aataaaataa actttaatac ttatatttca acaagatcac ctttttattg gttttatgaa 114120 gttgctgata aatataaacc tgttttttta aagtttaatg aagcaaattc aactgatatg 114180 agatttatgt taccaaaact tagagaattg acacctagcg atgaaaacta tttaagaaga 114240 ataccaaaaa cacctagtga ttttgaaaga tatgttagtc ctaatatttt taagaaagca 114300 agggaagcag attatttttg tgtttttaga tacaaaagca tttctgaaat aaataatata 114360 acagaaactt taggtataaa agtatatgtg cttccaaaaa aagtaagaga atggaatata 114420 ggttttactt ttaataaaat gataagaaac tttgtttttg gacattatat tttatttgaa 114480 aaaactaaaa aatcacaatt caataaagta ggagaaatag aactttatct aaataataag 114540 gtatttgtta cagataaaat gaagtttaaa acaagagatt taccttttag cgaagatgga 114600 acatattatc cgcttaagtt taaattaaag taatttatga taaagttata aatatataca 114660 tataaaaagg agatctaaaa tggaattcaa taattattta aatggtgtaa aaacgatgtt 114720 tcttgatgat attgagcttt caggaaaaga agatttaaga gagtcttcat tatcaagact 114780 ttatcaacac tataaagaac atgattcagg aactattagt gcttatcgcg gagaaagaac 114840 taaagcagaa aataaagaaa atagtaaaaa gttaaaaaat tatttgttaa gtaatgggta 114900 ttctgttaca caaattcaag gtgcttatga agaaacagat gaagacggta ataaaaaact 114960 tgtaaaagaa atgtcttata ttgttgttga tataaaagat aaaggaaact taaaaaaagt 115020 tttagttgat gcaggaagaa agtttaatca agaagctata actttttctg aaaaaggtgg 115080 tgattattat cttattatgt gtgacagtgg agaagaaata aaattaggta aacctatgtt 115140 tggaaaagat ggagagataa tttcaaaaat aaatggaaga ccttttattt ttactgaatg 115200 tgaagatatt gatagacaca catataacga cactttaaac aattataatc ctttaattgt 115260 tagaaaaaaa cttaaagata attataaaga cttagataat attatagtag aatctttaag 115320 tgaagaaaaa gaaaaattat atataaaccc tgattttaaa aaagctatga ataaagttga 115380 aaaaataaaa aaagatgttg caactaatta tgatcttgat gcaaaagatg atgaagattt 115440 agctaaagaa ttaatttata tagctgatat aattttaaaa gcttatgatg tgttaatgga 115500 tataagaaaa aaagaaatat ctaatcaaaa atcagcagtt ggttctgata aactttatgt 115560 tttaaataga gaaattgaaa agtttgttaa agataacatt gaaagttact tgtttgatga 115620 tttagagttt gatgttattt caaaacattt aaatgataaa caacttattg actatgttaa 115680 aagatttaaa aagataaaag cttaaatatt taagcttatt ttaatatatt ttataatata 115740 attataaata ttaaaagtta agcttttaat tattagatct aatatgtact tttggaatat 115800 tcaattattt gtttggtatt ccaagaccta cataaaatat tttttaagat agcctagata 115860 atacggcagt attacagaga gatcgatgac tatctcaaaa agtattttaa aattagctta 115920 tatttaagct aattttaagg tattttatat tataattatt tttgtaaaaa gggttagtaa 115980 agcttaacct ggataaagaa gcatgttgtg catgacagtt gtaggttcga tccataccta 116040 actcactatt attttttatt agggcgagta gctcaatggt agagcaaccg gctcataacc 116100 ggttggttat aggttcgatt cctatttcgc ccaccatata tgactatagc ttaattggta 116160 gagtacagga ttacaaataa tgttcaataa ctctaatata ttaaagttgt ggttgataaa 116220 cataattatt gcagattagc acagcggtag tgcaatcgac tgttaatcga tgggtcagag 116280 gttcgaaccc tctatctgca gccatttata attataataa atgtagaagt aggataattg 116340 gtaatccacc agactgtaaa tctggcgtct tttggtattg atggttcaaa tccatccttc 116400 tacaccatct taaacacatt taagttttct aaagaagatt taaatgtgtt tatttacgct 116460 ctataagctc ttgctagtac cttttataat atctataaaa ggtgaaaacc aagataagat 116520 aaacacattt aaatggtact aacagcaaag ttttaaggac attagtgata atgagattaa 116580 ttctctaaaa gtaccatgat taaaaagggt atttacagca aattaatatt ttatgatttt 116640 atgtgcccag tgatttcagt atatctgaat ttttaaatac cctgattttt ataaaggaaa 116700 gaaaatgaaa tttgttaatt ctctatcaaa tttatcttat acagaaaatg gtgctttaac 116760 attaagctct tcattaaatg tagctctaga tttatttttt attataggaa caactaatga 116820 aaataatatt gacaatgttt ttgaaaaagt aaaagaatca tttaatattg ataaggaatt 116880 aacttctaga atattgttat ggacaagaga cgcaagagaa ggtgcaggaa gaagagaaat 116940 atttaaaaga tttttagatt ttattgcaga aaatgataag gaaatttata aaagaataat 117000 tagaaaagtt cctgaattag gtagatttga tgatttaata acttataaac aattagattt 117060 agtaggaaat gaattaatta aaatactaga ttttaataat caattatgtg ctaagtggat 117120 gcctagagaa aaatcaagta aatctaaatt agccaaaaaa ttgatgaaat tattaaaatt 117180 aaatgctaaa gattatagaa agttattgtc ttctaatact tgtgttgttg aaaataaaat 117240 gtgttctaaa gaatggaact taatagaata tggaaaaatt ccttcaaaag caatggctaa 117300 gtataatgat gcctttgaaa gaaatgataa agaaagattt gaaaattatc aagaatcatt 117360 gataaaaggt aaatcaaaag taaatacttc cgcaatatat ccttatgaaa taattaaatt 117420 aatgttaaaa aatgatattt tagcaaatga aatctggaaa aatcaaaaaa attggatgga 117480 aggttctaag aaaactctat tccctataat tgatgtttct gcaagcatgt atacagaagt 117540 tcaaggaagt acaactgctt taaatatagc aatttcttta ggtatctatt taagtgaaag 117600 aaatggtaaa gattttaaag attattttat aactttttcc gcaaatcctg aaatggtaaa 117660 gatagaagga aatgatttaa aagaaaaata taaatccata aaaaaatcta attggggtat 117720 gaatactaat ttcgctaaaa cttttgattt gattttaaat agagcaaaag cttataattt 117780 atcacaagaa gatttacctg atgctctagt tattttaagt gatatggaat ttgacgaagc 117840 tcaacaagat aaaacaaatt ttgaatacat aagagattct tttaaaaata gtggttataa 117900 aatgcctgaa ttaatttttt ggaatattta tgggaaaagt ggaaatatac ctgtaaaaaa 117960 agatgaaaat ggaacttgtt taatatcagg gtttagtcct tcaatagtaa aaggtttatt 118020 aactaatgat ttaaaccctg aaaaaataat gtttgaaact ataaacaaag aacgatatga 118080 tttttaacaa tattacctat ttttgagggg attgatagtt aagacaacgg taaatgtaat 118140 cgagaatgat tatagaccta agagcttcct cgtagctcaa acctcaaaga tgggttaatt 118200 ttattttaag ttatactatg ctacaattcc tttaaatcaa taaaggatac acaatgatta 118260 aaaaaatact tatacatatt attttatttt caagtttata ctcttatgaa tacttagatt 118320 caaaagtata tgaagaaaaa ggtaatttag caatagatct gtatttttgt actaataatt 118380 tatctttaga aaaagatttt attattgaac atttaaataa tcaagttgat acattagaac 118440 aacaacaatc aaaatctgaa gtttatcaat acagaggaaa gcaatatgtt tttaacaaag 118500 gtaaaaacac aaaatatgat aaacctataa taacaataat tcatactaac aataattgtt 118560 ataaagcaac tgcattatat aaagtacaac atgatgatat aaaaacatct gttaataata 118620 attatgagtc ttattttaat ggatttataa ctaaaaatac tgctacaaaa aatcaagttg 118680 aacatgaaat aagaaatggt ttagaaaatg aaattaaaga aaatattata atacaagtaa 118740 aacaaaataa agacaagcac gaaacatatg ttaaaatacc agagtatttg tataatcaaa 118800 caaaagatga ttattatatt aatatgatat gtactgtgac aaatgttgat gatgagtttt 118860 tgtataattt tcaaataaaa aattataaaa aaccattaag atttaaagat aaaatgtgga 118920 atgaattaac tccatatttt aatactgatt gtaaaattga acttatagga aagtaatatg 118980 acattagaag aattaaaaga ttttcataaa agaattatat cagagtatga agaagattca 119040 aattggaatc ctactacagt aaaacatcaa ttaacaactt tatcaggaaa ggttggaaag 119100 tatttaaatt actggactag attaaaatat attcttattc aaattgaaga agagtttaat 119160 gaaaaatatg ttataatata tgaacattat aaagaaaact caaatataag ttatactaat 119220 gcagaaataa aagacttaat ttcgaagaat tctgatttaa aaaacaatcg tttgaaaaaa 119280 tcaactgtta taaacataat ggagtatctt gaaaaaggtg tagaaaatct taatagaatg 119340 agatatgata taactaatta tattgaaata gaaaaatttt taaatggaaa atcgtaaatg 119400 gtgacaatag aaaaaattaa tgaatcagcg tataaagtaa tatctgaaac acaattatat 119460 ttagatgaaa taagacaatt atgtagtgct aaaataccta atgcacaatt tttacctgct 119520 gttagaatgg ggtattcaga tggtgtaaaa tatttttaca aagattttaa cgattatctt 119580 atagttccta aaggttttat aaaaagtatt gttaaaagat taaacgataa gtacaaacta 119640 aatataagtt ttgatgataa tattgaaaaa gtatctaaag aacaatttga tagctttgta 119700 aaaaatatta atttaccttt tgaaccttat gactttcaat taaaagctgc ttttgatagt 119760 attaattcag gcaataaaat atgtgtaatg gctacaggta gtggcaaatc tttaacaatt 119820 tatattttat gtagatggtt tttagaaaaa tataagaaca cagaagaaaa aatattatta 119880 atagttccat caatagtttt attaaatcaa atgtattctg actttaaaga ttatggattt 119940 aatgatttag atttatttat tgatagatta ggtggagatt ttaaaataaa acaatttgtt 120000 aaaaaaatca atatatctac atggcaaagc ttatataaaa atgttgattt gtttaaagat 120060 ataagtgtta ttattgaaga tgaatgccat atggctgcta gcgatgtaca tgaaaaaatt 120120 atatatccat ctgctgtaaa tgctaaatat agatttggtt ttactggaac tttaccacaa 120180 tcttattgtg ataagctatc tttaatggct gttttaggta atgcagaaac ttatgttaca 120240 cctagagaac ttatagataa aggtttagct actgaaatgg aaataaaagc tataatttta 120300 aaatacaatg atgaaacaag ttctataata aaaacaataa gaaattatca acaagaaatg 120360 tctttttttc ttgatataga agaaagaaca gataaaatag caaaattaat agttaaagtt 120420 tcagaaaaag gaaatactat agctttattt acaagagtaa caaatggaga aatattagcg 120480 aaaaaagtgt gtaaattaaa atatggtgta gatgtagaaa tcagtgaact tagaaagatt 120540 aacaaataca atatattttt tgtaagtgga gaaacaaaag caagtgatag agaagcaata 120600 aggcaaataa tggaaaattg tgatgatgct ataatttttg gtactacttc tattatgagc 120660 acaggtgtta atattagaaa attaaaaagt ttagttaata ctatgcctgg aaaaagttat 120720 ataaaaataa atcaaagtat aggaagaatg cttagaaaac acgaaacaaa aaataatata 120780 gtttatcttt ttgatatagt tgatgatgga agaggaaaac attcaaagaa aaactacatg 120840 ttcaaacact atgaagaaag attaaagttt tatagagaaa attcatatta tatagacgaa 120900 atagttgtaa aagtatagca taattatgtt atacttttac aatgaaaggt gttagatgaa 120960 atatgttttt actttaatag aaaataactc acaaactaaa atattaaaca cagattataa 121020 taacaaagtt aattttaata atgtaatatg tgacagcata aattcttttt ctaagcttat 121080 tgaaaaaaac tttattttaa gtagacctat aaaatcaaat ggctgttttg aaagaaataa 121140 agataacatg gattatattg atgattgcgg atatattatt ttagacttag ataaggtttg 121200 caaagataac ttttctaaaa ttttaaatta ttttaaaaat gctaaatggg aatgtttaat 121260 ttgtaattca agatcataca attttattga taattttaat ttaaaagtaa tatgtaaaat 121320 tgcatataaa tctacagatg aaaatataaa aaacacatta ctttttttta aagaacaatt 121380 aagtgattta tgttctatag atgaatcagc aataagacat gctagttacc aagcaccatc 121440 tttaaaaact actgtattct ataagaatga aagtgatatt ggaataccat tatcgatatt 121500 accaaaatat aatacaaaaa atacttttgt aaatgcttct aaagaacaaa ttaaatggtg 121560 tttagattat ataaaatata acttaaaagg agatgtaaaa gaatatgcag gctattattc 121620 agtaagttta ccttgtgagg taaaaacaaa atattcttat tgtttatatg aaactaatcc 121680 ttttacaata tttcatccca atccaaataa aaatataaac atacttcaag agtatttaaa 121740 aacaaatgat ggtaaaatat ttttgaaaaa aagacaagaa agtattatat ctgatacttt 121800 agaatatact cctgatacta caataaatga aaagctttta aactttttag atataccaga 121860 taaaagaata atttgtgtta aatcacctat gggtagtgga aaatctaata taataacaca 121920 atacataagt gataaatcta aaatactttt tataagcgtt agacaaacat tagctaaaga 121980 tatgtcttta aaatataatt gtaagtatta tttagatgat aaaaaagtat tatttgggga 122040 aaattatgta tgccaaataa attctttaca taaaataaac ttagattatt ttgattatgt 122100 tattttagat gagtttgaaa cactgttaat gtatatgatt actcatgtta aagaatcacc 122160 ttatgctttg aatatattaa gaaagtttta tgaaatttta aatactaaaa aattattaat 122220 attagatgct tttttaagta atcattcaga tatattaaaa gacacatata gaatacaaaa 122280 cacttataaa gatgacacta atgttagttt atatacacat aaaaacacat ttttttctgt 122340 tttagaatat gtttgtaaaa ataaaaatga aaatgaaata gttacagttt cattttctac 122400 attagcagaa ttaaagatga tagaatcttt attaataaag cacggattaa aagttatatc 122460 tattaatagt gatacaaata gatttataag agataatata tttactgaat attttaaaaa 122520 gaaatatgtt aattatgatt gtgttttatt ttctcctagc attacagtag gtgtttctat 122580 tatgaataat ataaatcatc attttcattt tgataatagc actagcatag acgctattac 122640 atcgatacaa atgataaaaa ggtcaaggct tgctgaaaac attcatatat ttgttgaagg 122700 atgcactaat aatttagaac ctttgacaaa tgaaaaaaat gttatagatt cttatgatat 122760 agatgattta caatatttaa gtgattttta taataaatta aattattttt ataaagcaat 122820 agaattaaat cataaaatgt cttttgaaat gttattaaat aatcaattta agaatatcaa 122880 cataattaat aatgttataa gtaataatat aacacctgaa aataaagaaa aaaatatatc 122940 tttggatgag tttgaaaata gtattataaa agatgatctt attgaagaac ttaaaaaaga 123000 taaaaactat atagaatata ttaggaactt taagttttat atacttaata caaataaaaa 123060 tgagttctta gaaagatatt taatgaataa tccatctaac ttattagagt tatcagaaaa 123120 agcaaagttt tataagtatt gtgttactta tccaaatata aagttaaaag atatgtttac 123180 atataatgaa ataaaagata ataaatgtaa cacaacatat tatacatttt caaagttttt 123240 aaaatcttta ggttataaaa aaatgaatag aaactattat ttacctaaaa aatatataga 123300 acatttaagt aaaatataaa tagctatata ttaaaaaaca caaggagaat aaatgttaag 123360 tttaataatt gcattcgttg taggtgcttt ggcagggttt gcagcaggat tttttgtata 123420 tcacaataac aaagaaaaag cttcagttgt tgcagataaa attgaaacag caaaaaatga 123480 agtaattaaa aactaggatt attttaatcc tagtttttaa ggaattaaat gtattatagt 123540 aatgttgttt ttcaactaaa tgaagttatt cctgggttta catataatgt aaaaaaatca 123600 aaatcaaact tatatattac atttgctgct tatggttatt caattgatga tttagaaata 123660 acttataata acagcatcat aactatatct acaaataaag attatgttga agttaaaaca 123720 gatccaaaat ttacaaatta ttttccacag caaaataaat tttatattca attttggtgt 123780 ccacaactaa atggaataaa tgcttattat agtggtaatt ttttaaaact taattgctct 123840 ttaggagata ttagtgttaa tttaggaaat atacctataa cttttgttga agaagataat 123900 gatgtagata ctttggaaaa cacttctgat gatgttataa gtatagttca aatcaataat 123960 tttgatgata ctatatcaga tgttcaagat gagtttaata gtgaaataca aaattaaaaa 124020 ggattaataa tggcaaagtt agttttacaa agaaaaaaag aatatcaaga cataaaatgg 124080 gaaggcaaaa aagttgaaga ttctacaata ggtgaattag aattatttga tgataatgga 124140 gactctattt tcaaatgtgc tagttgtgaa aatataggac caagtactga tgaatcagga 124200 actgataaaa gaattatagc tagagaatat aagttaaaat ggtgtagttc aagtaaaaat 124260 ggactattag caaaaaaata tcctagatgg aaaaataaag atggatcaaa tatagctata 124320 tgggttgtat cagatgaagt tgatggattt gattcaagac ttattcgtat tcatacagga 124380 aacgcaccac aacatacaga aggttgtatt ttaccaggaa caaatgtagg aaatggtaca 124440 gttggtaata gtgtagatat cacaaatgat ctatttgaaa aaattgatga gttaggtatt 124500 gaaaacataa cttttgaagt aaaagaaata gattaacatt gttttaagaa taagtatgtt 124560 aaacttattc ttaaaatttt tattgaaagg aataatatga atgataactt agaaataaac 124620 tcatttaaag ttgttcatcc acatgatgta cttttagaag ttgcttgtat ttctgaaata 124680 aaatctgaaa gtggtattgt actaacactt caaccatctg ttattgatga tagagaaact 124740 caaggaaaag ttattcaaat gggttcagaa gttaaagata ttaaaatagg agatattgtt 124800 gtttttggaa agcaacatgg tattgactta ttgaaaaaag aagaagtaaa gtatatgctt 124860 attagagatg aatctttgct tggaatactt agatgattaa tatttttaaa aactatagag 124920 attttataat tttattagta ttgtttatac tattagcaat atctattaac aagtattata 124980 attaaaatat tcttgatagt attaaaaata ttataaataa tgttggatta aattataatc 125040 caactaatcc tgttactgta tctataatag attctgtttc tttcttatac acataatgtg 125100 tatatccaaa tgtaacatta aattcattta tagtttctgt ttgttcatct tgcatatcac 125160 ttccacttaa atctatagga aaaacatttt tataagtata acttcctact gcatttccac 125220 tataatttaa taatgttaac tttaattctc ctgtaagatt aatatctgtg tttgcttcta 125280 tacctttatt aatacctaaa aagctattaa cagcatcacc tactataggg atatcacttg 125340 ttacattaga tataaaacct gctcctatat tagcaactga acctacaata ttagcaaccc 125400 ctgatccagg tatagatgga gtatcttcac ttgtagtaac tcctgaatcc atgcaaaaat 125460 accaatattc tattattctt cttacacttg atttttcatc tataaaaaat gtcatatttg 125520 tagtattatc aagtttcatt aatgcaggga tgtttatagt tctaccatct aaacctacag 125580 gtgttgttgt tatagagtta gttggtaatg tagcactttt acataatata tctacagcgt 125640 tatcatatag cacccctgat acttttgcta tattagaagg taaagacaaa gatactttat 125700 atctaaaagg tctttgccct gaacttaaaa tatagtcaat agaatcaaat ttgtttaaac 125760 ccatacttat gactttcttc ttactttagc tacaagtttc atagttcttc taactttagg 125820 atcttttcta gtatatcctc tttttttaga agaccatgac atactatcag aaggagcttt 125880 tgcatttttt ttagctcgta tttttaattt tcttttaact tttggttgtt ttctatatct 125940 tttttgagct attctatcag ctacactcat atgtttaata ggtggcatta tatatccttt 126000 ttaattattt atatttaatt atcaaaagaa aaattaaaat tgtttaaatc attgccatca 126060 tcaaaaaatc ccatttctaa atatttaaca tcaccatcat ctatttctgt ttctccattt 126120 attttttgta agaataaatc ataatctatt atattattta aatctaataa aggaacaaac 126180 aataagctaa gagccataac ataatcatca tgtgcttttg aattttgtgc ttgatattta 126240 cctttaacat tacaaaatgt taatagctct tttacagtag cttcatcttg taataataat 126300 ttattgtttt caatgaataa tttcatattg ctaaggtttt tacttctatt acctttagtg 126360 gttcttacac ctaaccaatc tttatttgga tcttgatata tattatcata ctcatacatt 126420 tgaaataata aatctacaac acttgttcct gcaccttcat tgttttcaca tatgaatatt 126480 gcttcgttat aagttcttaa aatattataa aaaataggtg gagccattaa ataagatttt 126540 ggtattttgc ctgctcctac ttgtttaaaa ggaatacttg ttgcatctat tatatgaaac 126600 acaaatccat ctatagatcc ttttgcacca tctgctaaaa ccatgtattt atgattttct 126660 ttaggtgctt catatattct tactgtttct ccaaaattag gttcacttaa agttttaccg 126720 aacttaatat tagataaaac agtcatgtct accaaagtat cagaacttcc tataaactca 126780 caagcatatt cttgattcca agttctaata ccaccttcaa gagtttttat cataagttct 126840 ttataagctt catccctgcc tggaacttgc caccattcta ctttaaaagg tttataagag 126900 ctttttcctt caactgcatc catccacatt ttataccaat gatttaaacc tataggtgtt 126960 gaagttgcta ttatttgaga tttcttagaa gctgaaattg taggtataac tgaattacta 127020 aattctgacc atttttcaat aaaagcacaa ttgtgagaaa taaaaccatt tgtataatat 127080 ctattctttt tatgaacatt aattaaatca tatacataat ctatacctat atagtcaatt 127140 gaaattattt ttgaaagttt atctttatat ataataaaat catttatttt aagatctttt 127200 aatttaacaa aacctttact tgtttcaagc ttatgttctt ttgttacttt tatataacca 127260 caatcagtag ttactttata taattctttt ttctctctac ttatatcatc aaaatcacta 127320 aatccatctg gtgttaaaac ttcatacata tttctccttt tatcatatta agaggtatta 127380 tcctcttaat aatggaagtg gttcacaata attttctaat aatactgttt ctaatctttc 127440 taattcagtt gttgcttctt gtataattct ttcatagttt actttaatgc cacctactaa 127500 tggtgcatca tatttgccta agttagaacc ccaagttttt ttgcataagt ttaaagcaaa 127560 ttcttttacc caaatttgtt catatatacc gtcttcttct tctggtgtat acttatacct 127620 aacttctaac aaacattttt cagaagctat atcttcaaaa aactctaatg tatttgtata 127680 aggattaaaa gcataatttg gtattatagt aaacaaagta tctaacatag atatattagc 127740 taaaacagca aatatatttt gagtactata attactttga aacattgatc caaataacat 127800 tgcctgcatt tcagttggag ttactaccaa tccacctgga acagttaaac ctaaaaatcc 127860 accacctgtt gtttgcgttc ttaaagttat aacttcagat attttaggat ctaattttac 127920 ttttcttaca cctttaggta tatctattaa taaagttcct tttaatttac catacattgc 127980 aaactctgaa aatttttgta tagcaaaatt aatattctca tctatttgaa aatcagtaag 128040 ctccacagat ataactggag agcctagcat tcctaaaatg taatctttga gactttgcct 128100 agtagccata tcaacaccca tagtattaac tattaacagt tacattaaga gtttttgata 128160 tttgatttcc accattagct tgtgctttaa ctgtgattgt aaatggtcca gttttacttg 128220 cttttggtgt tacttgaatc ttattacctg atttaacagc ttgtatattt tgattattaa 128280 attctaatgt aaaatctgaa gcattagttg aaactgttac ttcttgcatt ggagcacttg 128340 cattggcgaa agttaaacta ttaggtgaaa gagttaaagt tgttactact gttgcttttg 128400 taacagttaa aggtaattct ttcatagctg ttctaccttt attatctgta agttcaaata 128460 tagctttacc tgaaccttct ttatttcctg taaatgtttt gtcaccttca ttccatgtag 128520 ctaaatcact tggttctact gttacaacag ctgatgtaat tgatgaccca tctgtggctg 128580 tataagttat tgcttgtgac tttttaccgt tttcaaaagt taaattatca gatgataaag 128640 ttacttgtaa atctggataa aaaacattat ctttaccacc aaaaaattgt ggaaatttaa 128700 ctgctacatc tgatggatat tcaaatccag gtaaaatata attagtagtt ccattaatgt 128760 ctacaaactt tggagttcct gttgtataag aaaatttttc ttgttttggt atattagtca 128820 taataattat ccttttatat aaatagttta tattatttat aaaaaggaat ttaatggcaa 128880 atatgtttaa tggtctattt gaaactgtta aaaatgcttt tttaaatgtt gaagaaaaag 128940 aaggatctat atcatcaaat gacccacata aagaagccaa tcttacaaaa gatgatattg 129000 tattaggtta ttttgatgag gggaattata catataatag ttttgattca gattcaatag 129060 gtgatgtatc taaacaagca aaattaataa aagaatatag aaaagtgtct tcatatcctg 129120 aagtttctga tgctattgat gaaattatta atgaaatggc atttgtacca aataatactg 129180 aatgttgtta tttaggattt aaagataatg tattaaccga taacttaaaa gaagcttttc 129240 aatctttatt tgatagttct tgtgaaatac tacaattaga tcaaaatata gatgttcttt 129300 gtagaaggtt ttatatagat ggtcaattag ttataggttt atcttataat gataatacaa 129360 ctgatatatt aaatgcttta attatgaatc catcaggact ttactataat aaaagtataa 129420 acaaatggca atatataaca gaaaatacat ttaatgataa tgatacttca attgtaaatt 129480 gctatgaccc agaagaaata ataagaatag attcaggatt atattcagat ggtttgatat 129540 tatcacattt aaatagtgtt ataaaaatag taaaccagtt acaaactctt gaagatttaa 129600 tggtccctat gaggtattct cgttctgtat caagaagagt atttaatata gatgttggta 129660 atttaccttt tgaaaaagct atggctgctg ttaacaaaat taaagaacag tttagataca 129720 aaaaacatta taatgtagaa acaggtagta tatcaaatag taactctata caatctatgg 129780 tagaagatta ttattttcca aataggggtg gaactaaagg aacacaagta gatgtattag 129840 atgaaacagg aaacttggga gaaacaggtg atttagatta ttttaaaaat aagctatata 129900 atgctttgaa agtacctaca tcaagattaa tgggagaaaa taaaactgta tttgatttta 129960 gttctacttc aatagaatct actgaaataa agtttttttc ttttgttaat agattaagac 130020 aaagatttgg cgttttaata cttgaactta tgaaaagatt tgcaataata aacaatgttc 130080 ttactgaaga tgaatttgat aactattcta agtatatatt cataggatgg gaaaaagaat 130140 caaacttttt agaaagacaa aacttagata ttttaaaaca aagactagac ctatatacag 130200 aatttaaaga gtatgaaggt gatatattta gtaggcaata tttactaaaa aatgttttaa 130260 aaatgactga tgaagaaata aatcaaatga gagaagaaat attgcaagaa ggtagtcaaa 130320 aagtagaagg tgaagacgag tttggtaatg atatagaaga tgaagaactt gatgatatag 130380 cacaagatac tttagatgat gaaaacgata tagaagataa tgaagatatt gatatacaag 130440 ataatgataa tgatatagaa aataaagaaa atgaaaagtc tttagaaaaa gaaaaaatta 130500 atgttaaa 130508

Claims (9)

1. 캠필로박터 제주니(Campylobacter jejuni)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 OPT-CJ1(수탁번호 KCCM12723P).
   
2. 삭제
3. 제 1항의 박테리오파지 OPT-CJ1을 포함하는, 항생용 조성물.
   
4. 제 1항의 박테리오파지 OPT-CJ1을 포함하는, 사료 첨가용 조성물.
   
5. 제 4항의 사료 첨가용 조성물을 포함하는, 사료.
   
6. 제 1항의 박테리오파지 OPT-CJ1을 포함하는, 소독제.
   
7. 제 1항의 박테리오파지 OPT-CJ1을 포함하는, 세척제.
   
8. 삭제
9. 삭제

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