KR102003770B1 - 신규한 포도상구균 특이 박테리오파지 sa3 및 이를 포함하는 항균 조성물 - Google Patents
신규한 포도상구균 특이 박테리오파지 sa3 및 이를 포함하는 항균 조성물 Download PDFInfo
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Abstract
본 발명은 포도상구균, 특히, 황색포도상구균 및 표피포도상구균에 특이적인 사멸능을 갖는 신규 박테리오파지 SA3, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 SA3을 이용한 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 포도상구균, 특히, 황색포도상구균 및 표피포도상구균에 대한 특이성이 매우 높고, 상기 박테리오파지 SA3은 상기 균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 SA3은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SA3은 포도상구균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
Description
본 발명은 포도상구균, 특히, 황색포도상구균 및 표피포도상구균에 특이적인 사멸능을 갖는 신규 박테리오파지 SA3, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
포도상구균은 50% 이상의 건강한 사람, 동물의 피부, 비강 등에서 흔히 발견되며 여드름, 농가진 같은 경증의 피부감염증부터 폐렴, 수막염, 패혈증과 같은 생명을 위협하는 질환들에 이르기까지 다양한 질병을 초래할 수 있다. 또한, 원내감염의 가장 흔한 5가지의 원인 중 하나이며, 종종 수술 후 상처 감염증을 초래한다. 미국 병원에서 매년 약 50만 명의 환자들이 포도상구균 감염증에 걸리는 것으로 알려졌다.
특히, 자연계에 널리 분포되어 있는 황색포도상구균(Staphylococcus aureus; S. aureus)은 그람양성의 구균이다. 이는 건강한 사람, 동물의 피부, 비강 등에서 흔히 발견되며 황금색 색소를 생성하고 용혈성을 가지며 응고효소(coagulase)를 생성하는 종이다. 상기 균은 화농성 질환이나 창상 감염 등의 피부 감염, 골관절염, 폐렴, 패혈증 등을 일으키는 병원성 높은 대표적인 유해세균으로 알려져 있다. 황색포도상구균이 생산한 장독소(enterotoxin)는 100℃에서 30분간 가열하여도 파괴되지 않기 때문에 감염형 식중독과 달리 열처리한 식품을 섭취할 경우에도 식중독이 발생할 수 있다. 또한, 황색포도상구균은 일반적으로 환경에 대한 저항성이 강하여 건강한 성인의 비강, 피부, 구강 등에서도 존재하고 동물의 상처부위를 통한 전염이나 식품의 생산 과정, 제조 공정 등의 여러 단계를 거치면서 식품 유통망을 타고 짧은 시간에 전국적으로 전파될 수 있으며, 전파된 황색포도상구균은 사람에게 전이되어 또 다른 매개체가 될 수 있다. 따라서 황색포도상구균과 같은 유해세균을 억제하기 위하여 사람과 동물의 질병 치료와 예방에 항생제를 사용하고 있으나, 황색포도상구균에 의한 식중독 발생률은 노로바이러스와 살모넬라, 병원성 대장균과 함께 꾸준히 높은 수치를 나타내고 있으며 매년 발생이 증가되고 있다(Lee JH et al., Korean Journal for Food Science of Animal Resources,30:410, 2010).
또한, 항생제 내성 포도상구균인 메티실린 내성 황색포도상구균(methicillin-resistant Staphylococcus aureus, MRSA)은 주로 병원 내에서의 항생제 남용에 의해 초래된다. 지금까지는 메티실린 내성 황색포도상구균이 주로 사람에게 문제가 되는 것으로 인식되어 왔으나, 최근에는 유럽을 중심으로 가축에서도 분포하고 있는 것으로 보고되었다. 우리나라에서도 1999년 애완견에서 메티실린 내성 황색포도상구균이 최초로 보고된 이래 젖소 우유, 돼지 비강 등 다양한 동물에서 보고되고 있다. 메티실린 내성 황색포도상구균은 아미노글리코사이드, 퀴놀론 등 대부분의 항생제에 강한 내성을 지니고 있어서 치료 중 선택할 수 있는 항생제가 극히 제한되어 있다. 현재 치료제로 반코마이신(vancomycin)이 쓰이고 있으며 이의 남용은 또 다른 항생제 내성균주의 출현을 초래할 수 있어 심각한 문제로 보고되고 있다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
그러나 현재까지 포도상구균, 특히 항생제 내성 포도상구균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 포도상구균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
이에 본 발명자들은 포도상구균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 포도상구균, 특히, 황색포도상구균 및 표피포도상구균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 포도상구균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SA3을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 SA3을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 SA3을 개체에 투여하는 단계를 포함하는, 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 포도상구균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SA3을 제공한다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 SA3을 개체에 투여하는 단계를 포함하는, 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 SA3을 이용한 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 포도상구균, 특히, 황색포도상구균 및 표피포도상구균에 대한 특이성이 매우 높고, 상기 박테리오파지 SA3은 상기 균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 SA3은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SA3은 포도상구균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 황색포도상구균에 대해 특이적인 박테리오파지의 스크리닝 결과를 나타낸 도이다.
도 2는 박테리오파지 SA3의 황색포도상구균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 SA3의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 SA3의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 SA3의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 SA3의 열 안정성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 SA3의 황색포도상구균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 SA3의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 SA3의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 SA3의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 SA3의 열 안정성을 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 포도상구균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SA3을 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명에서, 상기 포도상구균은 황색포도상구균(Staphylococcus aureus) 또는 표피포도상구균(Staphylococcus epidermidis)일 수 있으며, 항생제 내성 포도상구균을 포함하나, 이에 제한되지 않는다.
상기 항생제 내성 포도상구균이 내성을 보이는 항생제에는 메티실린, 반코마이신, 페니실린, 리팜피신 등이 포함되며, 바람직하게는 메티실린 또는 반코마이신이고, 보다 바람직하게는 메티실린이나, 이에 제한되지 않는다.
본 발명의 박테리오파지 SA3 전체 유전자의 크기는 142,827 bp 이며, GC함량이 30%, 전체 ORFs의 수는 223개이다. 상기 박테리오파지 SA3은 포도상구균, 특히, 황색포도상구균, 메티실린 내성 황색포도상구균 및 표피포도상구균에 대해 용균활성이 탁월하다. 또한, 상기 박테리오파지 SA3은 230-240 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속한다. 본 발명의 박테리오파지 SA3의 단백질 패턴 분석 결과 70 kDa, 50 kDa, 43 kDa, 32 kDa, 30 kDa 그리고 16 kDa 크기의 단백질을 포함하는 것을 확인하였다. 또한 상기 박테리오파지 SA3은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.
본 발명의 박테리오파지 SA3은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 SA3은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 포도상구균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 SA3을 포도상구균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 SA3을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 SA3은 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 박테리오파지 SA3로 명명하고 2016년 12월 2일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하여, 기탁번호 KFCC11713P를 부여받았다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 포도상구균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명에서, 상기 포도상구균은 황색포도상구균(Staphylococcus aureus) 또는 표피포도상구균(Staphylococcus epidermidis)일 수 있으며, 항생제 내성 포도상구균을 포함하나, 이에 제한되지 않는다.
본 발명의 박테리오파지 SA3은 다양한 포도상구균에 특이적인 사멸능을 가지므로, 상기 균들에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. 본 발명의 박테리오파지 SA3은 포도상구균 중에서도 황색포도상구균, 메티실린 내성 황색포도상구균 및 표피포도상구균에 더욱 특이적이므로, 본 발명은 상기 균의 감염에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 이용될 수 있으나, 이에 제한되는 것은 아니다.
본 발명에서, 상기 포도상구균에 의한 감염성 질병은 식중독, 유방염, 피부염, 패혈증, 화농성 질환, 폐렴, 골수염, 농가진, 균혈증, 심내막염, 여드름, 수막염, 골관절염, 피부감염, 장염 및 요로감염 등을 포함하나, 이에 제한되지 않는다.
본 발명의 약학적 조성물은 1 × 103 내지 1 × 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 × 106 내지 1 × 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU(plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.
본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 SA3을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 SA3은 기존 항생제에 비하여 포도상구균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 사료 첨가용 조성물을 제공한다.
축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 SA3을 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조 상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해 효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에(Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 SA3을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 SA3을 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 SA3 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 포도상구균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 소독제를 제공한다.
포도상구균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 SA3을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SA3을 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 SA3은 포도상구균에 특이적 사멸능을 가지므로, 상기 포도상구균에 노출되었거나 노출될 가능성이 있는 가축의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SA3을 개체에 투여하는 단계를 포함하는, 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 SA3은 다양한 포도상구균에 특이적인 사멸능을 가지므로, 상기 균들에 의한 감염성 질병의 예방 또는 치료에 사용될 수 있다. 본 발명의 박테리오파지 SA3은 포도상구균 중에서도 황색포도상구균, 메티실린 내성 황색포도상구균 및 표피포도상구균에 더욱 특이적이므로, 본 발명은 상기 균의 감염에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있으나, 이에 제한되는 것은 아니다.
본 발명에서, 상기 포도상구균에 의한 감염성 질병은 식중독, 유방염, 피부염, 패혈증, 화농성 질환, 폐렴, 골수염, 농가진, 균혈증, 심내막염, 여드름, 수막염, 골관절염, 피부감염, 장염 및 요로감염 등을 포함하나, 이에 제한되지 않는다.
본 발명에서, 용어 "개체"는 포도상구균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 SA3 또는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 SA3 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 SA3의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술 분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예
1:
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박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리
황색포도상구균(Staphylococcus aureus)에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장, 도계장 및 농장 부근의 하수로부터 채취하였으며, 박테리오파지 분리에 사용된 황색포도상구균은 (주)옵티팜에서 채취한 야외 시료로부터 분리 동정된 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 황색포도상구균과 함께 35℃에서 24시간 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 상기 여과액을 이용하여 스팟 테스트를 통해 대상 시료에 황색포도상구균을 용균할 수 있는 박테리오파지가 존재하는지 스크리닝을 수행하였다. 그 결과를 도 1에 나타내었다.
다음으로 전배양된 황색포도상구균 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 BHI(Brain Heart Infusion) 탑 아가(top agar)((Brain infusion solids 12.5 g, Beef heart infusion solids 5.0 g, Proteose peptone 10.0 g, Glucose 2.0 g, Sodium chloride 5.0 g, Disodium phosphate 2.5 g/L) +0.6% agar)를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% BHI 아가 플레이트에 중층하였다. 이를 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(황색포도상구균) 배양액 150 μL에 혼합한 후 0.6% BHI 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl(pH7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% BHI 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 BHI 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, BHI 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 확인함으로써, 상기 박테리오파지가 황색포도상구균에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예 1.1에서 확인한 황색포도상구균 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x107 PFU/mL로 희석한 후 전배양된 황색포도상구균 1.0x109 CFU/mL과 혼합하고 MOI(Multiplicity of infection)를 0.01이 되도록 하여 35℃에서 100 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 SA3(Bacteriophage SA3)"로 명명하고, 2016년 12월 2일에 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 수탁번호 KFCC11713P를 부여받았다.
실시예
2: 박테리오파지 SA3의 전체 유전자 분석
박테리오파지 SA3의 전체 유전자를 분석하기 위해, 박테리오파지 SA3 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액 (Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 HiSeq 4000(Illumina, USA)을 이용하여 유전자 시퀀싱을 시행하였다(마크로젠, 한국). 유전자 시퀀싱 분석을 수행한 결과, 박테리오파지 SA3의 전체 유전자의 크기는 142,827 bp 이며, GC함량이 30%, 전체 ORFs의 수는 223개임을 확인하였다. 상기 분석한 박테리오파지 SA3의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예
3: 박테리오파지 SA3의 형태학적 특성
박테리오파지 SA3의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경(Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 SA3은 230-240 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.
실시예
4: 박테리오파지 SA3의 단백질 패턴 분석
박테리오파지 SA3의 단백질 패턴을 분석하기 위해, 1.0x109 PFU/mL로 준비된 박테리오파지 SA3 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 SA3은 70 kDa, 50 kDa, 43 kDa, 32 kDa, 30 kDa 그리고 16 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예
5: 박테리오파지 SA3의 다양한 세균에 대한 감염성 조사
박테리오파지 SA3의 다양한 세균에 대한 감염성을 조사하였다.
박테리오파지 SA3이 포도상구균에 대하여 용균활성을 나타내는지 확인하기 위하여 미생물 자원센터와 한국생명공학연구원 생물자원센터에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였고, 메티실린 내성 황색포도상구균은 아시아태평양 감염연구소로부터 분양받은 균주를 사용하였다. 그 결과를 표 1에 나타내었다.
상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 SA3은 황색포도상구균 외에도 메티실린 내성 황색포도상구균(MRSA) 및 표피포도상구균에 대해 용균활성을 나타냄을 확인하였다.
다음으로, 박테리오파지 SA3이 포도상구균 외의 다른 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.
(+: 용균활성 있음, +/-; 약한 용균활성 있음, -; 용균활성 없음)
표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 SA3은 Escherichia coli, Bacillus cereus 등의 병원성 미생물과 Bacillus subtilis , Lactobacillus plantarum 등 생균제로 흔히 사용되는 균주 등 포도상구균이 아닌 다른 속의 세균에 대해서는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 SA3은 포도상구균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예
6: 박테리오파지 SA3의 pH 안정성 조사
박테리오파지 SA3의 pH에 대한 안정성을 확인하기 위하여, 다양한 pH 범위(pH2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 SA3 배양액을 7.0x109 PFU/mL가 되도록 준비한 다음 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 SA3은 pH3-11의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 SA3은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
실시예
7: 박테리오파지 SA3의 열 안정성 조사
박테리오파지 SA3의 열 안정성을 확인하기 위하여, 40℃, 50℃, 60℃ 및 70℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 SA3 배양액을 7.0x108 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 10분, 30분 및 1시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계 희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.
도 6에 나타낸 바와 같이, 본 발명의 박테리오파지 SA3은 40-70℃의 범위에서 30분 이상 안정한 것을 확인하였다. 이를 통해 박테리오파지 SA3은 내열성이 우수한 박테리오파지임을 알 수 있다.
상기 실험으로부터 박테리오파지 SA3은 포도상구균, 특히, 황색포도상구균 및 표피포도상구균에 대한 특이성이 매우 높고, 상기 균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 SA3은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SA3은 포도상구균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 SA3을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예
1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 SA3 1 × 106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1 앰플 당(2 mL) 상기의 성분 함량으 로 제조한다.
1.2
액제의
제조
박테리오파지 SA3 1 × 106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 SA3 1 × 106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
SEQUENCE LISTING
<110> Optipharm.CO.,LTD
<120> Novel Staphylococcus specific bacteriophage SA3 and antibacterial
composition comprising the same
<130> 1-41P-1
<150> 10-2016-0177968
<151> 2016-12-23
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 142827
<212> DNA
<213> Direct input
<400> 1
taaagttctt ctaaatgagt ttcgtatata accttttgaa ttttatttag tggttctaaa 60
tctaaattcc taataagttt ttcgtatttt cttgaattct tgaagttaat agtattaggc 120
atagcaagag cttcatcaac gtctttagta tagcttacaa catctgaata gatatctact 180
tcttttacat atagaccctg agttaaactt ctaaatacta cctcattatg tgctataact 240
tcttctttct tttctatgct catttgtaaa cctcctggtt tattctaccc aaacaagtac 300
gtactctaag ctagttaatg atactgattt aatattattt aattcttgca atttcttaat 360
atctacatca tagtttttac ttatagtcca taatgtctct cctgctctta ctttatggta 420
atacttattc ccctctttaa taaggtcatc caatattacc tacctccttg agtaataatt 480
agcctgtaga taacatataa gtataagaac aaagtttaca aattcagtag ctataatatg 540
aacataggta tgtgataaaa ccatacttac tatcaacgaa gctaatccta atccaataat 600
aaggaataga aatctgtttg tcccttctga acttttagtt ttataaaatg ttgttatctg 660
agttacatac gcaaggataa tagtaatagt tgctacagtt tgtgttaagg ctgtaaagtc 720
acttaataaa aatagtaaca atgagaacac aataataaaa ggtatagaga aataatcctt 780
ttttctatat gaagctacta ataagcaaac aatacctaga gttaaattaa gaccaactga 840
tactacttga aacattgtag catcagttaa tagtaaattg taaaaactaa tacctactgt 900
agctacaatt aaataccaaa aataactact aactccttta acactatccg atttaactaa 960
agctattaga cctggtatat aacctactgt aactaatata gcatataata tactcaagta 1020
atgtgataaa ttatccatct tgttctccta atttctctaa tatttctaaa acttcttccc 1080
aagagataaa tccttctccg tctgttaatt ccaaaaccat accataaaca aattgatttg 1140
tactaaattc agctctgtcc gggtcgtcat aaccttttcc atgtccttga cgaatatccg 1200
agcaataaat taaaacaggt ttatttacaa tattttcaag tttttctacg attaattcct 1260
cttcttcact taaccaagtt tcaaatctat ctgatatata attaaagtgt tcttctccat 1320
tatcatatat atggttaata gtttcttgtg cttgatgctt catacctagt aaaataccaa 1380
gttctgcaat cgttcctagc ccctcattaa gaatatcaaa cacaaatata tctgagtctt 1440
gcatagcttt aaagtcattg tttaaaatgc gctctgctaa accagtttgt tctgcattag 1500
ccttatcatt aattgattta tctttatgag ggctgtaagg agtgactcct acaatacctt 1560
ctacttgctt atgctgtttg tctctataat ctaccatagc ttggttaagt agatgacctc 1620
ccatataaat tactttgtct ttaatataat taaccattta tagtatctcc tttttcttct 1680
agaatacctc ttaaaatgtg tggcatcttt ttcttaattt gtttttctat aattttcatc 1740
atattttctt tttcttcttc cataatatca tcaacaaaat tttgacctac ttgtttcata 1800
attaaaccaa aattttctaa ttctaaatca tcttcagaca atctgttttc ttctatagct 1860
ctaaaaatca ttttttccat tcttgatttt gtgatagcat aatctgccac agaatcatta 1920
cttctaactt ctgatttcat tttcttacga ctaaactctt taaattcctt agatactaat 1980
ttaaagtaat catcatgttc tgatttacca tctaaatatt taataacaat accttctcct 2040
gtattaggtt taacagtcat atctgattgt cctactaaat cttgaatttc ttgaggattt 2100
aattcattaa gataaaaaga tggttctaca atcattaaag tttttacagt tttcaaacct 2160
aatgtttctg ataaagaaat gacttctgaa tgaggtaaat aggtttcact atccttatcg 2220
tatacatcga atacataaaa atcattataa caatcttctt tataatttac cttatgttta 2280
actaaccatt ctccaaatat aataatacct tctaatatag ataaatctaa tttatctgtc 2340
atgttttcat gtacccaatt ataaaaaccg tttaatgttt cgttttcatt taattttttt 2400
ctacgagaga aacagactaa ctcaccattc tcggtagtaa aacttgcgtt gcttccatct 2460
aatttttctt gaattacaaa acctctatct ttaaatttgt ctaaagataa tcctttattt 2520
tttactttag tataagattt cattaattag ttatcctcct ttgaattatg tactattgaa 2580
aataaaataa gacttacact tgctaaaaat gctaatacca ctaaaccagg taaatttaga 2640
actgttgata agaataatga tattgcactt ataatataaa ctaaaccgct tagaaataaa 2700
gttaataata caattgttat aagttttacc aaccaactgt tattaataaa taccttagct 2760
aaataattca taaaaaatcc tccttagtta ttataaagta agtatatcat aactaaagag 2820
gtttgtcaac atattatttt accatttaaa attgtctgcg tactgagcta acttagaacg 2880
gaaattaact gtaaaattat ggaataccgc accatcataa tttttaaaat attccatata 2940
atctccaaaa cctgatttac tttcattttt taaatctatt tgcttgaaat ttccttcaac 3000
tattactgta gaattttttg tatgaatcct tgtaagtact ttcttaagtt cacttcgttt 3060
aaagttttgt gcttcattta taattatagt agcatccctt aaattaccgc ctcttaaaaa 3120
taaatgtgat atttgggata cccaacattc acctaattta tcttctttga cattatcttc 3180
catcattaac atttcggtta tttgttgttc aggactcata ttaagttcaa taagggcatc 3240
atgtaatccc atgaaataag ccatttcttt ttctgtttgg ttaccaggtc tactacctaa 3300
atcttctgat acaggtgaaa ttacaaatac taattttctg ttcttattta gataatcagc 3360
ataagcacaa gctactgaac acattgtttt acccgtaccg gcttgacttt cattccaaag 3420
tatttcaaca ttatcattaa agaaatcctc acagaaatct aattgctcag ttgtagcttt 3480
ttcaaggaat tcattgaata ctagatgttc tcccatgtta tatcttacat taggataatc 3540
ctttaactta aagtctaact cttttagttg tattgccata ttttaaagtt cccctatcta 3600
taaatagttt tactctcttt taatatagta ctaattacct atatattcac ctgttgaaga 3660
acaatagtta ctgcagttac attcaggata attttcacaa acttcttcat cttcatcatc 3720
aaataagtct tcatgataaa tactagaatc aaaatctaca atacaatttt cccctttacc 3780
tttagatatg cctgtgtaaa taacttcatc aaccatatcc caatcattac ttactaagta 3840
atttacagta tttgatactg aatcattatc aggtaagtag atatcaccat ctgtaaactt 3900
aattaaaata tctccttgag ggagtacatc attaattaaa tcaatttctg tttcttcttc 3960
aattgtaaat acagttcctt ctagcttttc aggagtagta tgtgttaaat gtttaacatc 4020
ttctcctgat tcttcataaa atcctactgc attcatttcc ttgttatact ttgcaataaa 4080
tttaccatta tcactgacta aatattgact gtttgcatta taatcttctg catcttctaa 4140
agtcatagat gggttatggt ctttaacata ataactaatt tttctaacat ctgttgtttg 4200
aattttcttt ccttcacctt taattactga attaattttt ttcataatat tttctccttt 4260
ttatatatca attgattttt ttgcaagatt atcagcgtag tcattccatt tatcatttga 4320
gtggcttttt acttttacaa agtttatatc tattactttt tggtattctc gtatcatatt 4380
aatatatgtt ttacttagaa tatttcttgc agaccaagta ccttcatacc aatgtattaa 4440
accaatataa tctatataaa ctattgcctg attgtatcct aattttatag cctcttcgat 4500
accataacaa caagctaata tttcacctgc aacattatta tactttatca atcctggttt 4560
gtcaacactt ttactaattt ccgctattat atttccttct ttacttacta agacagcacc 4620
tgagcctact ttacctttat tataagatga gctaccgtct gtgtatatat ttacactatc 4680
ctgcatattt ataatcctcc ataaattgag ggaattcaca atctgaatat acttctctgc 4740
agaaagatac tgaaatataa ttaaaatcaa aacatttgaa acagtgttct tgaacttctt 4800
ttttgtcttt agcaatcaca ttaaatttaa aaccatcagc tattactgta aatactcctt 4860
ttttcataaa acaaatacct ccactaattt tattttaaat taataactaa ctcaataaac 4920
gatttaatag ttttattttt accttcatca atatctgaaa agaaattaat taaactatca 4980
tcttcatcaa ataaatcttc aacatcatca aatttattta atatatctgt aacactataa 5040
ccttcttctg atatatactc atgcaagtct tctccatcct ctgacagagt tgcttctatc 5100
ttaccattct tactttcaat taaatacaaa gtatttaata ctttaataga atctactact 5160
acactgtaat tactaatagt aggatactct gtataaagta tttccacatt agtattcata 5220
taactatcaa ttacagaatt aactgtgtcc ctttttaatt cagatacatt atgttttcgt 5280
atagtaggga attcttcgtc atattctact aattcttttc tatctgtatt caataatttg 5340
tctaaagaag ataataatac tattttatat tgattgtccg gtagactatc tgtaatttcc 5400
ataatggtta aaaaagtatc ttcacctaaa actttattta tatcttgtaa ttcaaatgaa 5460
tctaccattt caatagtatc atctatatca tctgtagtca ttaaaaaatt aactaaatta 5520
ttattctcca tcgtcttcct ccaattcttt aaatagctct ttacctggag tatttaacgc 5580
cttctctaac ctcattaaat tagcacttct tggtttcttt ttaccatact cccaataaga 5640
tataagagaa taatggactc ctatctcaga agctaggctt cttaatgtat gtcctttttc 5700
tactctaatt ttttgaagat ttagaggttt actttccttt ttttcatcca taactatttc 5760
tcctctactt ttaaaaattt aaaatcctca gatgcttttg cattttttag tatatactct 5820
tgtgatttat ttcttgcctc tgctttactt ttagcatata actctatatg aaatacatga 5880
ggttttttta aagatggtga ttcatatctc caataaactt taaaaagtag tgtttctttt 5940
tttagaacat taattctaaa ccatctttta aatttattca ttcattatcc tcctttattt 6000
atttgttaaa ctaattatag catagttaac ttatgaagtc aactataata tacaaaaaag 6060
actaagaaat taatcttagt cttaatatat taataactat tatgtgcgtt gtggtatgca 6120
agagctcctg atgttgaacc gtaacggtca atcatatatt gttttgcacc tttagtttgt 6180
tctgctatag aacccccact ccatgattta cctaatcctt ggaatagtcc ttgagctcct 6240
gatgatgcat taacggcatt aggattcagt gtagattcac gcatagcaat ttcaatcatt 6300
gcctcgtctc cacctgcttg tctaatttgt tctgctacag aacctcctgt agaactagtt 6360
gattgtgtag gttgtttagt ttctttttga actggtgctg atgttggttg tacttctttt 6420
ttagtatctt gtttattttg agtatcaaat tgcgcttgtt gttggtctac tttttgttca 6480
ggtgtttgtt cttctcctgc taatctagat actgtattat ctacttgagt tgaacctgag 6540
tgatattcgt atccaaaatt accattataa ttatagaaat gataagtaaa ttctccgtca 6600
ctgaatgaga aatcatagtt accttcttga attggttttg tatttacttc tactgaattt 6660
gatttagctt gttctgctaa cttattataa tcaatttcgt ctgcactagc ttcgtttgta 6720
gcaatacctc caaaagtaat agccgtacct aatgctaatg ttgcaaaaat tgttttcttc 6780
ataaatttaa aactccttaa ataatttttt agaattgttt atttgtaaat cgacataagt 6840
aatcataaca tatatcttta aataacgcaa gtataatata gcactaatta gtgtaatatt 6900
attaaagttt tattacaaac attacagtta tcagataatt aaagacaaaa aaagagaggt 6960
attaacctcc ctaatttatt atttccctgt tacgtctacg atagttccgt ctccgccaat 7020
ttgaataggt tgtttaccat cccatttttc aattaactgt tgacgtaata tcttatcaga 7080
taaagaagat tctctaatct cattggcttt tttatcacca ttagcttcta cttctttttt 7140
cttagcattt tgttcagcaa tttgtttatc aactttagta cgttctaact cttggttagc 7200
tttaacacgg ctgtcaattg ctttttgagt gttcttatct gctttagggc tagataatgc 7260
aatatcctca attacaaatc cttgtttttc taagttatca tttaagctat ctaaagtatc 7320
ttttttaatt tctcctgtct taacaccaaa tgcatcaatt acagaatatt tagatactgc 7380
ctgacgaaca ttatcttgca cacgtgaacg caagtatcct ttttctagtt cttcaatatc 7440
tgcactacca aaacgattaa ataaatctac agctttagtt gcatctactt tataagatac 7500
atcaatatcc atttgtaaat ttttgccgtc tgaagttgct acatttaaat ctttatattt 7560
atgtgtttgt gttttagttg gatatttatt taccttatca aaaggtgctg ttaagtgcca 7620
accaggtgat ttagtatctt ccttaacacc atttactgag tatacaactc caacatgacc 7680
ttgtggaatc tttgtaatac acattaataa aataataaat cctataattg ctaaaaaccc 7740
taatactcct gaaataacta ctgactttct cattacattt ctcctttttc tatttctttt 7800
attaagctat ttaaagcttt ttcctcttgg tctatttctt gcttatcggc tctagttaca 7860
attgattgtc tgcggtcgtt taagaattgt tttttatact ttacatattg ttctaaaccg 7920
tattcatcta atgtaccttg cctaactaat tccctgtatt gttttcttat gttacttttc 7980
ttttctttca ttgaaagaaa atcgaataca taacttatac caaaacctac aaggactaga 8040
aaaacaataa aaatagcaaa gtatgttaaa aataatgcca tgtaattcct cctttatttg 8100
attacatata taactataca ctatgtattt aattttgtca acactttttt gcaaaaaaaa 8160
atagacggat tttaaatccg tctaaatttc tattctattt gaatactccc caagcaaccc 8220
caggtatatg attaggtgga actccttgac aagttctaac agggcaatat actctgttac 8280
cattgtaagc attgtaacct atccaaatgt gacctgcttg gatacaaact tcgtcatata 8340
caattgtagc tcctgccggt aagttacctc ctactggagc atttaagaat ggagaaccta 8400
ttctagttac tataggttgg ttaccattaa caaatgttgc attttccggt ttgtaccaag 8460
ttccgtactg gttctttttc caagagcctg ttactggtct agttgccggt gtacttgcgc 8520
tacttgtttt accgtcttta actactgtag aacttgaagt tcctttatcc atgtagtttt 8580
taatttgttt aatgaaataa tcttttagtt tattcattat tgcttgagat ggtcttcctt 8640
gtgttactgg attaaatcct gtatgaagaa ccatagaacg atgaggacaa gctgttggaa 8700
caaattccat atgcaatctt acagttttac gattaggagt aagaccccat tctttaaatt 8760
tctctgcagt aaattggaat actgcttgtt cgtttttaag gaattgagca tcactagcac 8820
tcattgattg acagacttca atacctgcaa atctaaagtt acctgagttt gctcctgttc 8880
catctcctgt gtgccaagca atttgattct tagcatctat tgcttcccat acataacctt 8940
cagagccata gtaatgagca ataccattag catatctagc ataacctgcg ttagctaatg 9000
aattctcgta ttgttgccct gaagaacgac ctgcatcgtt gtgtattacc attccttcag 9060
gtttcttacc acgtttatcc attgtatagt taatatggtt cttagaaact tttagtgttg 9120
ctttcttttt aggtgcaggt gttttacttg cacttttctt agctgtttct tttttaacag 9180
tagttcctgc ttttacaggt atctcaataa aatgagttaa tccgtaataa ttatctacac 9240
gttttgtagg ttttttatta gcgtaaccgt tccagttttg ctctaaaata gtaaatgtag 9300
aagtattacc tccatcatat acaataccta tgtgacccca ttgctgataa ctaccggatg 9360
taaatacagc aatccatcct tttttaggta ctgtagaagg tttattttca tgtattttaa 9420
atccagtacc ataactttgt ttgatttggt ctttagcatt accccaagtt ctaactttat 9480
tatctgttaa ccataataca taatcagtaa ttaagtcttg gcactgtgca tgatagtaac 9540
catctgcgtc aattgctcct gcttccatta caccaaacga tgggtcatag cttgtagctt 9600
ttttaattct ataaggactg tctactgtac cttttgcata agcgtctaaa cgtttattta 9660
tttctgcttg agtcttagcc attacttaac ttcctcctct gcaaatactt taccgtgttc 9720
ctcggtatct tcttcatctt gagaaggtgc tgaaccgcca tcaatttcat cttcaatagc 9780
aggtacttca tcactatcat ctgtatcagg ttctgcattg ttttcatagt tgtctaattc 9840
gaaagtgcta gctgtgtttg catttgcttg ccattgaaca aattcattag ggtctttact 9900
atcacgaggt tttatataat ctgtttgaac aatatcacta tctttaagac ctttagtatt 9960
attatcaaca ataataccta aacctgctaa taatgttagt atagaaccta tgatatttac 10020
accttgctca atttgagctg agtagtctaa accaaaagca cctgtaattt gattagcaaa 10080
tactgctact gctgatataa ttgctaccca aaatgtttta ctcttagttc ttgtgctaaa 10140
gtttattcct ccaacaactt taggttgttt agtttcatta gccattaaaa aaccgacctt 10200
tctattatat ttatttctaa caataatata acagtaggtc ggtcatgttt atctatatta 10260
atttaacact tactcattaa tttgatttag ttttttgata acttcagaca tttgtttgtt 10320
atctaaatct tctaatttag tttcaggtaa taactctaat ttatcccaaa cttcttcttt 10380
attagatact ttattattaa taattgcctt accaactaaa ctttccgtat aatataattg 10440
ctttgctgat gccatttgta tctctccttt taaatatgta aagtatatag ctagtatcgt 10500
atcctaggaa caaacacttg cgctatatac tcaatgaaac tctaccctca ttcgaggaca 10560
cagcaaaccg attcgtcaac cgcacatgtg aattctcaag tttcatttat gtaacacacc 10620
ctctttgatt tgcacaaaga ctaagggttt tggagaccct tgtactacta attatactaa 10680
gggtgtttat tatggtttct attggatttg aaccaatgac acctagagct tcaatctagt 10740
gctctaccat ctgagctaag aaaccttgta acgactcata cgagactcga actcgtactc 10800
tctgccgtga cagggcagtg tgttaaccag ttacaccaat gagccaaaat aaatgctata 10860
ccctaacctt accttgatgt atagcaggtt ttcatataag ctcgaagcaa cgattattac 10920
cactcataac aactatatat taagtgaaag gaggtgaaat gaacaaaacg tggtaattgg 10980
tacttatata ggaagtatgt ataatctaca aggagtaagt tattggttca taaaggagtg 11040
tgaacaataa atacatgaaa gagtgaaagt ctactccttg tagattcttt tttaattatc 11100
aatcaaagga ggaaactgat aattgttaat aataaactat aaagaggaaa atatttatag 11160
tcacattctg atataatgca actaaatatc caagcataac ccgtctcacg aggaacctac 11220
ctataagacc tgttattaag tgaatcacta cgattgactc tattaaggag ctaccttaag 11280
tccatctcac gcaatttaaa agggacttac aaaccgtata acgatagtaa gtttattaaa 11340
taatgtgata ttaacatatt agttaataac tttcacatgg tcgaagaaaa gtaaatttat 11400
ttgatttcca aattattttt atcaaatata gcttcttttg aacctgtaga tttatgctac 11460
tcatactaat aacctctatt atctaacaca tttctgtgct ccaactacag ttagtcgtta 11520
cagcgtatct ttctaggatt ccgctaagac cctagaaaga aattaaaccc tagccgttat 11580
catactctac agaccttata agtaagtacc aagtatacca atcgtattta acaatactaa 11640
tgacgaccca tcctaccgat atatttccga taggttttga ttcgtttgat tatcttgtac 11700
cttatgacta ccaaatcatt attcagtcac tatgctcaga tatttagttg tattattata 11760
tattaattat aacataattt ttagtacttg tcaagttaat tttaaaaaaa attatagaag 11820
taagataaaa ttcttacttc caattaaaat tataaggatg atacacattg ttattgttta 11880
aactggaaaa caatgtaaga aaaaacagtg atgtgtaagg tatttgtttt attgttaatt 11940
acattatagc atatactgat acctttgtca agttaattta atactttttt taaaatatta 12000
gttatctttt gttagttctt cctgaatagc atcccatctt ctttctgctt cactacgatt 12060
atcttctata tgttttgtag ttttacaaca tttgatacag tatatatctt tgatatgacc 12120
ttcttctctt ttatttgctc tttttcttgg tactttgaat acattaccac attctttaca 12180
tattaaactt gagtaaaaca ttttttgtct tttcataatt aatcaattcc ttttcttgtt 12240
ttatttgata atttaactat atactatatt gataaataag tcaacagttt tctaaaaata 12300
atttaaatta ttttgaagaa tcctttaata ccaagggtta caagagaaaa agtacgtatt 12360
tagaaaataa ggagtactcc tattatatat aattatattc tgatataagt aattaataat 12420
attaaatata taattataat taataaggtt gggaaaattg aattaaatat aatctgatac 12480
ttggtaaaac tactcaatat agaagtaaaa tcctttagta tcagtactta cagacaaaaa 12540
agtacgtatt tagaaaataa ggaactctcc tattatagtt atatatactt attaattatt 12600
attaattact atctaaatat ataattataa ttaataaggt tagagagtca acaaaaagac 12660
aaataaaaaa gtgactactt aaagtcactt gttaatttaa aaaactattt taaatgattc 12720
aatcattctt gggttaatat aaattaaact agaactagca tcttcagttg tattaacttt 12780
tattgatgct gaatcagaac cactaatcat atagtctata tcttttctag tgtaaccctt 12840
ttcgtcagat gatactaaaa aatatttagc accacttaac attgttattt caatatgttt 12900
tgacatctac aatctctcct atgcaaattt gttaaagaca aaggatagta tagcacctag 12960
aacgagtaaa agaaccttct cagtagtatc cttcttccta gtatctttag tttttgtact 13020
ttcagcaagt tctgaaatct tttcatcaag tctttctaat tggacgtaaa ttgctgattg 13080
tttttcacta ttgacagcta catctttatc tatactaact atcatttttc ttagttcagc 13140
tacctcaact tctaaatctt tgaaagttcc tctatctata taattacctt cttgtatctt 13200
agacttaata gtttctactt gagaaacaag gttgtttatc tccttatcca actagaatca 13260
cctctaaggt ctaaccgttt cagattcaga atggatatca taattttcta agaaatcatt 13320
gataatctcc atataattat ccgtaacgac ttttccgtaa gatgtttttg tatcaatttc 13380
aaacctaagc ttaccaaaac tttggaggtc taattctttt attacaatat tagggtcatc 13440
agaaggaagg taataatagt cgaagtatat aattgagcca tttattaata ctctgtctat 13500
tctatagacg tggaaatagc gtctgtctct tttaaaatgg gctagtgcat ctttaaactc 13560
taacttaagg atacccttat atttagtcaa agtggtaacc tccttactat taatttttaa 13620
atttacttat tttgtggtat aatagttatg ataaaggcag ttattataat tatattaaga 13680
ataatgataa taattatttt ttctgagaaa ataagccaaa tactaaaaac agataaagca 13740
tagatagctg atagatatac tatattaaga gttaccttac ttttatcttc tttatagata 13800
gaataaccta aagacgttgt aacaccacta agtataaaat aatagaaaca aaaaagaggt 13860
atagacagaa aaaaagatac gataatcatt gttaaacacc tatttctttt tgacctatta 13920
tttatagaac ttttagatta caccactaat ataacattaa aagccagtca taaaagtcaa 13980
ttgttagatt aataatataa taaaaaaaga caataggagg ttaaagtggt tgaataataa 14040
catagctata ttcatattca aaacactggt tatcattata ttcttactac taattttgtc 14100
tgttattaat tccttgtccc ttatttattc aataagaccg agtgtagtta tgacatactt 14160
tatatttggt ggtattgttt ctaatgtcgc acttactata acagataagt tcttactgaa 14220
gaaagaagac cccctacctg aatatgttct taaaaaagta gagataaatg ataaagaaat 14280
aagaataatc aagaaaatca tagaaagtaa ctacggtata acagcagaag agataaaagt 14340
tagggctaaa gcacaaagaa gaatagagga agatagtaaa aaggaagatt acgatgaaaa 14400
caaagaaaga aattaaagaa caaaggaaag agcttaagga tggtgctaca tctgtttctt 14460
tagtaaaaaa aggagataag agaatagcta gccctagtag aatttgtagc ctatgcggtc 14520
agcagttatc aggtatgaat tacactaaag gaaaagcatt atcaaaagtt aatcattttc 14580
atttacagta ttctaagtat atttattttg atatttgcgc agatatcaac aattgttata 14640
agaatttaag aaaaagaggt gaaatggatt gagtgcagaa aatattagag atataattaa 14700
caagaaaaag ttagaagaag aggatacaag aaaatatata gctgatggat ttatgaatgg 14760
tataggtaaa ttaatgtatg aattcaataa aaaagtagat aataaagaaa tagaagttaa 14820
agaccctaat gatttatata aactattcgt gatattctct caaatgcaaa atatggttaa 14880
tgaaacttct gaaggtggag caatacctca gctatctaga cctcagcaag aattatttga 14940
cgagattaca acagaagata gtaatggaga atctacagtt gatttacaga agatacaaga 15000
aatgacagca gaagatatta cagcaatgat ttctgaaaaa gaaaaagtaa tgaatgagga 15060
aaattcagaa acattctaag gagaaagata taaatggatg gaaaagaact aattaagata 15120
gcacaagaaa catttcaaac tgaaaaaata acaagagaac agatagacca tataatcaat 15180
atgttaaacc cttctaccta tatgcttaag tatcacacac taagaggaca ccctataact 15240
ttcagcattc ctaatagaga tagaagtaaa gcacaggctc atagaccatg gcaaactagg 15300
attgtaaacg atactcatcc taataaggct gtaataaaat cacgtcagtt aggtcttagt 15360
gagatgggtg taatggaaat ggttcatttt gcagatatgc atagttatgc caatgcaaag 15420
tgtttataca cattccctac aaatgaacaa atgaaaaaat ttgttcagtc tcgtttgaac 15480
cctgtattag aaaaagaata ttttagagat attgttgatt gggataaaga ctctttaggt 15540
tttaaaaaga taagaaactc tagtttattc tttagaacaa gttctaaagc aagtactgta 15600
gagggtgtgg atattgacta cttatcctta gatgagtatg atagggtaaa cttattagca 15660
gagtcatctg cattagagtc aatgtcttca tcacctttta agattgtgag aagatggagc 15720
acaccatctg tacccggtat gggtatacac aaattatatc aacaatctga ccaatggtat 15780
tatggtcata gatgtcaaca ttgtgattat ttaaatgaaa tgagttataa tgattacaac 15840
cctgataatc ttgaagaaag tgggaatatg ttatgtgtta accctgaagg tgtagatgaa 15900
caggctaaaa cagtacagaa tggtagttac caatttgttt gtcaaaaatg cggtaaacca 15960
ctagatagat ggtataatgg tgagtggcat tgtaagtatc ctgagcgtac aaaaggtaat 16020
aaaggggtac gaggatacct aataacacaa atgaacgctg tatggatttc tgctgatgaa 16080
ttaaaagaaa aagaaatgaa tacagaatct aagcaagcgt tttacaatta tattttgggt 16140
tatccatttg aagatgttaa actgagagtt aatgaagaag acgtttatgg taacaaatca 16200
cctattgcag aaacacaatt aatgaaacga gatagatatt ctcatatagc tattggtata 16260
gattggggaa atactcattg gataactgtt catggtatgt tacctaatgg taaggtagac 16320
ttaatacgat tattctctgt taaaaagatg acaagacctg atttagttga agcagattta 16380
gaaaaaatca tttgggaaat atctaagtac gaccctgata ttataattgc agataacgga 16440
gattcaggaa acaatgttct aaaactcatt aatcattttg gaaaagataa agtatttgga 16500
tgtacgtata aatcttctcc taagtctaca ggacagttga gacctgaatt taatgagaac 16560
aataataggg ttacagtaga taaattaatg cagaataaaa gatatataca agcacttaag 16620
acaaaggata taagtgttta tagtacagta gatgatgatt taaaaacttt cttaaaacat 16680
tggcaaaatg ttgttattat ggatgaagaa gatgaaaaaa ctggagaaat gtatcaagtt 16740
attaaacgta aaggtgacga ccattatgca caagcaagtg tttatgccta tataggatta 16800
acaagaataa aagaacttct taaagaagga aatggtacaa gctttggttc tacatttgtt 16860
tctactgatt acaaccaaga aggaaataaa caattctact ttgatgaata gaggtgaaat 16920
agacttgaca gataaattat tttatggtac aattagtaat gaagaaatta ataaaagtgt 16980
attgaatttg ttattaggtg aggaattatc tttagattat gtttctaaaa atagtgatac 17040
cttagatgtt aaatatgaac atgtttataa atctctagga ttcgataatt tctttgattg 17100
ttttttatat gctaatagag aacctgaaat agtccataaa ggtggagata aaaatcttgg 17160
tgggctaaat aaggttaaac gtactgttat tcgtaatggt aaagaaatgg aaatgacagt 17220
ttacgaagac ggtaataaag aaaatgatag taaagaaaaa caagaaggca aagaagaagt 17280
tagtagaagt gcagtaggag caagagctat ttctaatggt gaagaaggaa aggtaaaccc 17340
taaaaaggta gcaaattcat tatctagttt aagtaaaaaa ggtgtcgatg tatcacatgt 17400
tagtacaaac tcatcattgt acaaagagtt tgttgatgat aatggggata cattaggaat 17460
tacatctttt aaaagaactg aaaatgatat aatattagaa tcttatgcaa gttcacccga 17520
ttcagatggt gtaggggcta gagctattat ggaactatta cgtttaagta ttaaggaaaa 17580
taaaaatgca gttgtgtatg acatagaatt gcctgaagct atagagtatt taaaaacttt 17640
aggatttaaa cctaataaag atggatacat cttaagaaaa aaagatgtaa aacaattctt 17700
aggtgattat agtgatttta tttagcactg tagtcatcta ttctattgta tttattctct 17760
atattatatt aaaaacaatt tatgtaaagt ctaatatgaa tagaatagat aacacaactg 17820
aattattaaa aatattacag gaagatattg aaggaaagat aaaaaaggaa ggaagaaata 17880
aatgacttta gaagaaaata aattaacatt agaagaatca ataactccac ttagtaaaga 17940
ggagaaagag gatagtatta aagaatttag tagtttatta tgtgaaatgg taaatagatt 18000
atacaagtct tacaatgtat ttagacaaga ccctatggat gaaacgcaac gtttagatgg 18060
ttctctaatg gtctttcaaa gtagactaaa tgacccttta acaggagatt tacatgacaa 18120
gatgtataaa cttgcttttt caaaacgcat tgatattttt gaagctaaca agcaattcag 18180
aaaagatgta gaatcaggta aggcaattga actaggtgat gtagctatta tagatacagc 18240
attaagtaat attctttcag gtaacgagtt ccaaggaagt atttcgttta tgcttagaaa 18300
agactttgaa gaaaaagaaa gaattagaaa agaagaagaa gagaaactta ataacttata 18360
aaagggaaga attatgagac tatataaaat gaggtatcat aattgaaaaa gaaaccacaa 18420
ggcaatgaga taatcataac cataataacg gttatgatag caatatttgt agtcattatg 18480
accatatttt ttaataaata ccaagatgct aaagaagata aagatagata tcagagatta 18540
gttgagattt ataaaaaagc agatgataat gatggagaga ctaaaaagaa atacgtaaaa 18600
agattaaata aagctgaaga agaacttaaa aaagtaaaga aagaaacaaa ttataaagac 18660
tataataaga agtcaaataa agaaagacaa aaggaagata aagaaactag agagaaaata 18720
tatgatgtaa ctggtgatga tgacttaata ttagtaaaaa ataatattga gtttagtgat 18780
aaggtagata aacctgaaat acttattagt gaagatggaa ttggtacgat aactgtccct 18840
acaaacagtg gttatgaaaa acaaacagta ggttctatta ttactagtgt attaggttcc 18900
ccgttcttat caactgattc acccggtata gatagtttag gtatcattaa tagtaatgtt 18960
tatccaaata cagtagatag tatagtagaa gatacaaata cttctactga taatgtacta 19020
aaggataatc ctattataac aaatccagtt gaaccaacca caccttcaga tatattacct 19080
cctattgata atccgtcagt tcctatatta cctgaaaatc ctgtagacaa taattcagga 19140
aatatagata atacggataa tccaaaccct ccacctccag gatatacaga tgaagatgga 19200
ggtagaggct caggtggtgg aggtaatgtt gaacccccac caacggaaga accttcagat 19260
aacggtaata caggaggagg agattgggaa gaaaaacctg acccaggaga agagccatca 19320
gataatggta atacaggaga caatgaagga gaggtaactc ctgaacctga ccctacacct 19380
tctgagcctg aacaacctaa tgaaaaacct aatgagggta atggtaatga agaaaaacca 19440
tccgaaccat cagataatcc tgatgaaaat ggaggatggg aaactgagcc ttccgaacct 19500
gaaacacctt ctgagccgga cgataaggtg gacgaagagg ataaaaacga agatacaaca 19560
gaggataaac aacctacaga acaaccggac gataataata cagataatga ggataaaact 19620
gaagaggagt aattactcct cttttttgtt tgctatatta aataagagat aaatataaaa 19680
aaattgaaca ttacggtggt gaaaactttg ataggaatga atgttataac gtcactatca 19740
gtagtattta cctgtttaag tcttttaact ttaatgattt ttgttcacag taagttctcc 19800
agtaaaaacg tttttgtttt gtatgtaatt tatgctataa taggaatagg tacatacata 19860
gttttaacta tgtttcaaac aacatctgta cttattaaga atgatgtaat agattccata 19920
gaaaatactg aacattatat tggattcaat gaccctataa ttatatttac tataagtttt 19980
ataggggcaa tacttggagg aatttggtac aagatgatga aaattattaa aaagagtaac 20040
tttaaagata aaaaataaaa aagacggtga ataggttgat attctctaaa gataagaaat 20100
gggatgaagc aaaagatttc atcaaaggtc aagggatgca agataattgg atagagattg 20160
tagattatta tagacagata ggtggaaaac acgtagctgt ttttattgct ttaaacaaag 20220
taaaatacat gattctagaa gcaacaaaag acaataaagt aatattagta gataaagata 20280
ataatatact attagaagat tatgatattg ttatggaaag taaaaaaatg ttttattaca 20340
ttgaagaacc gttcgaggtt aaaataaata tccctcgaca tattagagat gtaacttata 20400
ataatactgt tgtattaact acagtaagag ggagtagagg tgactagtaa ttggcagatt 20460
tatttaagca attcagatta ggtaaggact atggtaataa tagtaccatt gctcaagttc 20520
ctattgatga aggattacaa gctaacatta aaaaaataga acaagacaat aaagagtacc 20580
aagacttaac taagtcttta tacggacaac aacaggctta tgcagagcca tttatagaaa 20640
tgatggatac taatcctgaa tttagagata agagaagtta catgaagaat gaacataatt 20700
tacacgatgt tttgaaaaag tttggtaata atcctattct taatgctatc atacttacac 20760
gttcaaatca agtagctatg tattgtcaac ctgcaagata ctcagagaaa ggtttaggtt 20820
ttgaggtaag attaagagac ctagatgcag aaccaggtag aaaagaaaaa gaagaaatga 20880
aacgtataga agattttatt gttaatacag gtaaagataa agatgtagat agagattcgt 20940
ttcaaacttt ctgtaagaaa attgttagag atacttatat atatgaccaa gttaactttg 21000
aaaaagtatt taataagaac aataaaacta gattagaaaa attcatagca gtagaccctt 21060
ctactatttt ttatgcaaca gataaaaaag gtaaaattat taagggtggt aagaggtttg 21120
ttcaagtagt agataaaaga gtagtagcta gttttacttc tagagaatta gctatgggta 21180
taagaaatcc tagaactgaa ttatcttctt cagggtacgg attatcagaa gtagagatag 21240
ctatgaaaga atttattgct tataataata ctgaatcatt taacgataga tttttctcac 21300
atggtggtac tacaagaggt attttacaaa tacgttcaga ccaacaacaa tcacaacatg 21360
cattagagaa cttcaagcgt gaatggaaat caagtttatc gggtatcaat ggttcatggc 21420
aaattccagt ggtaatggca gacgatatta aatttgttaa tatgacaccg actgctaatg 21480
atatgcaatt tgagaaatgg ttaaattatc ttattaatat tatatctgct ttgtatggta 21540
ttgaccctgc agaaattggt ttccctaata gaggaggagc tacaggttct aaaggtggtt 21600
ctactttaaa tgaggctgac ccaggtaaaa aacaacaaca atctcaaaat aaaggtttac 21660
aacctttact tagatttatt gaagatttag ttaatagaca tattatatca gaatatggag 21720
ataaatatac attccaattc gtaggtggag atactaagag tgctacggac aaacttaata 21780
ttcttaaact agaaactcaa atatttaaaa cagtcaatga ggctagagaa gaacaaggta 21840
agaaacctat tgaaggtgga gacattatct tagatgcttc attcttacaa ggaacagcac 21900
aattacaaca agataaacaa tataatgatg gtaaacagaa agaacgttta caaatgatga 21960
tgagtttact agaaggagat aatgacgatt cagaagaaag tcaatcaaca gattctagta 22020
atgctgataa agaaatagga acagatgcgc aaataaaagg tgacgataat gtttaccgaa 22080
ctcaaacatc taataaaggt caagggagaa aaggagaaaa atcttctgac tttaaacatt 22140
aattaataag cctagaataa atctaggctt tgtttatttt tttgtaattt aattttgata 22200
aaggtaataa ctatgatata ctatatgtaa ttgatattaa tacataaaaa atattaatat 22260
ttcacttaca agttattatt gttatattat taacgtaaaa gtaaataaaa taacaagtgg 22320
aggtgtagac acctttggaa gaaataaaat ttaatgcttt tgtacctatg gatttgaaga 22380
aatctgtatc aacagcttct gatactaatg agtattctat agtttcagga tgggctagta 22440
ctccaagtat ggatttacag aatgatatag ttaatcctaa aggaatagat atagagtatt 22500
ttaagtcaca agggtacatt aattatgagc atcaaagtga taaagttgta ggtataccta 22560
cagagaattg ctatgtggat atagaaaaag gtttatttat tgaagcaaag ctatggaaga 22620
atgatgaaaa tgttgttaag atgcttgatt tagctgagaa attagaaaaa tcaggtagtg 22680
gaagacgttt aggtttttct attgaaggtg cagttaaaaa acgtaacata aatgacaata 22740
gagttattga tgaagttatg ataacaggag ttgcattagt taaaaatcct gctaatcctg 22800
aagcaacatg ggaaagcttt atgaaatcat ttttaactgg tcacggtaca tcacctgaca 22860
ctcaagttga tgcaggagct ttaaggaaag aagaaatagc atctagcatt acaaatttag 22920
cttacgtcac taagattaaa gatttaaaag agtttaatga tgtatggaat ggcgttgttg 22980
aagatttgag taaatctaat agtatgggat atgaggaatc agtccttacg ttacaactag 23040
ctaaaggttt atctcgtaaa gatgcagaac tagcagtaat ggatataaac aaacaaaaac 23100
tagaataggt aaggagaata cattctatga gtaaagaaat gcaaaatatt ttagaagagt 23160
atgataagtt aaatgctcaa gaggcagttt cgaaatctgt agaagatgat gaaaagaata 23220
cagtagaatc taccgaagaa caagtagcag aaacaactga agaaccggct aaagaacctg 23280
aaaaggttac tgaggaagat gctaaagaag cacaagagca aggtgaaaaa gttgaatctg 23340
aagaggtaac agaggacact gaagatgagg aagttgaaaa atcagctaaa gaatcaaaag 23400
accctgtaga ccaaaaagat actaaaacag aaaataaaga caacgagaaa cgtaaaaata 23460
aaaaagataa aaaagaagat tctgaatctg atgatgaaga caaagatact gacgatgata 23520
aagataagaa agaagataag aaggaaaaaa cttctaaatc aatttctgat gaggatatca 23580
caacagtatt taaatctatc ctaacatctt ttgaaaactt aaataaggag aaagaaaact 23640
ttgctactaa agacgattta agtgaagtta gtaaatctat taatgagtta tcagcaaaaa 23700
tttctgaaat ccaatctgaa gatgtttcta aatcagtaga cactgatgaa gaagaagctg 23760
tagaaaaatc agtaacatct acaaatgggg agcaagaaaa agtagaaggt tatgtttcta 23820
aatcagtaga cactgaagag caagctgaaa ctggtgaagc aaaatcagaa gatgctgaag 23880
aagtacaaga ggataacaca tttaaaggat taagtcaaga agaaagaact aagttcatgg 23940
attcttataa agcacaagct aaagacccta gagcttctaa acatgactta caatcagctt 24000
atcaatctta cttgaacatt aacactgacc ctactaatgc atcagagaaa gatattaaaa 24060
ctgtaaaaga ctttgcacaa atttaattaa tgcacaaagt tgtgttatat tatacggtgt 24120
aactaaagaa tataaatagg gtacatttta ctgtacccta cataaaataa aaagaacaca 24180
aatgaaaggt gataaattta tatgactatc gaaaagaacc tgtcagacgt tcaacaaaag 24240
tacgctgacc aattccaaga agacgtagta aagtcattcc aaactggtta tggaatcact 24300
cctgatacac aaattgacgc aggagcttta cgtagagaaa ttttagatga ccaaatcaca 24360
atgttaacat ggactaatga agatttaatc ttctatcgtg atatctcacg ccgtcctgct 24420
caatctacag tagtaaaata cgaccaatat ttacgtcacg gtaacgtagg tcactctcgt 24480
ttcgttaaag aaatcggagt agcaccagta tctgacccaa atatccgtca aaaaaccgta 24540
tcaatgaaat acgtttctga tactaaaaac atgtcaattg catcaggttt agtaaataac 24600
attgctgacc catcacaaat ccttacagaa gatgctatcg cagttgttgc aaaaacaatt 24660
gagtgggctt cattctacgg tgatgcttca ttaacttctg aagttgaagg tgaaggttta 24720
gaatttgatg gtttagctaa attgattgac aaaaataacg taattaacgc taaaggtaac 24780
caattaactg agaaacactt aaacgaggcg gctgtacgta tcggtaaagg tttcggtaca 24840
gctacagatg cttacatgcc tattggtgta cacgcagact tcgttaactc aatcttaggt 24900
cgtcaaatgc aattaatgca agacaacagc ggtaacgtta acactggtta cagtgtaaat 24960
ggtttctact catctcgtgg attcattaaa ttacatggtt ctacagtaat ggaaaatgaa 25020
ttaatcttag atgaatcatt acaaccatta ccaaacgctc ctcaacctgc taaagttaca 25080
gctacagttg aaactaagca aaaaggtgct tttgaagatg aagaagaccg tgcaggatta 25140
tcatataaag tagtagttaa ctcagatgac gctcaatcag ctccttctga agaagtaaca 25200
gctacagtat ctaacgttga cgatggtgtt aaactttcaa tcagtgttaa cgctatgtac 25260
caacaacaac cacaatttgt ttctatctac cgtcaaggta aagaaacagg tatgtacttc 25320
ctaatcaaac gtgtaccagt taaagatgca caagaagatg gaacaatcgt attcgtagat 25380
aagaacgaaa cattgcctga aacagcagac gtattcgttg gtgaaatgtc accacaagta 25440
gttcacttat tcgaattact tccaatgatg aaattaccat tagctcaaat taatgcttct 25500
attacatttg cagtattatg gtatggtgca ttagcattac gtgctcctaa aaaatgggct 25560
cgtattaaaa acgttcgtta tatcgcagtt taatagaata agaaaaactg aatacaagag 25620
aatagggata aacttagggt ttatcccttt tttattaaaa taaacttgaa gggactcaat 25680
aaatatgtta tactataaga aattactaaa tacaaaaatg gctaccattt atggtacagt 25740
agatattgac aaagatggag tagttaaagg attaactaag gaacaagaaa aagagtttgc 25800
aaatgttcca ggttttgaat ttgaagaaga aaagaaaact actagaaaac aatcagcttc 25860
tactagtaaa gaagaagaac ctaaagaaga ggaaaagaaa gcctctacta gaaaaactac 25920
aagtactact agaaaatcta cagcacgtaa aacaacagcc aaaaaagatg aaaataagta 25980
aagggtgaat taaatggtta actcaatgtt tggaggggac ttagaccctt atgaaaaatc 26040
attaaactat gaatatcctt atcatcctag tggtaatcct aaacatatag acgtaagtga 26100
gatagataac ttaacattag ctgattatgg atggtcacct gatgcagtta aagcttatat 26160
gtttggtatt gtagtacaaa accctgatac aggacagccc atgggtgatg agttttataa 26220
ccatatatta gaaagagcag taggtaaagc tgagagagcg ctagatattt ctatactacc 26280
tgatactcaa catgagatga gagattatca tgagacagag tttaatagtt atatgtttgt 26340
acatgcttac agaaaaccta tattacaggt agagaactta cagctacaat ttaatggtag 26400
acctatatat aaataccctg ctaactggtg gaaagtagag catttagcag gtcatgttca 26460
attgttccct acagcactta tgcaaacagg acaatcaatg tcatatgatg ctgtattcaa 26520
tggataccct caattagcag gtgtataccc accatcagga gcaacctttg cacctcaaat 26580
gatacgacta gaatacgtat caggtatgct tccacgtaaa aaagcaggta gaaataaacc 26640
ttgggagatg cctcctgagt tagaacagct agttataaaa tatgcattga aagaaatata 26700
ccaagtatgg ggtaacttaa tcattggtgc cggtattgct aataaaacat tagaagtaga 26760
cggtatcaca gaaacaatag gaactactca atcagctatg tatggtggag ctagtgctca 26820
gatacttcaa ataaatgaag atataaaaga actattggat ggtttaagag cttactttgg 26880
atataatatg ataggattat aaggagggtt agaaaatgga aaaaccgtat atgataggag 26940
ccaactctaa ccctaatatt attaataagt caacaacata cactactaca acacaagcag 27000
atgaacagga taaacctaag tatactacta ggctagagtt tgatactatt gatatgatta 27060
ggtttattaa tgataggggt ataaaagtac tatgggaaga agcatatttt tgtccgtgtc 27120
ttaatcctga cacaggtcat cctagagtag attgtcctag atgtcatggt aaaggtattg 27180
cttatttacc tcctaaagag actataatgg caatacagtc ccaagagaaa ggaactaacc 27240
aattagatat agggatatta gatacaggta ctgcaatagg tacaactcaa ttagaaaaga 27300
gaatatccta tagagatagg tttactgttc ctgaagtatt aatgcctcaa caaatgattt 27360
attttgtaaa taaagataga attaaaaaag gtataccatt atactacgat gtaaaagaag 27420
taacttatat agccactcaa gatggtacag tctatgaaga agattatgaa attaagaata 27480
atagattgta tttaaatgaa aaatatgaga accatacagt aactttaaag atacttatga 27540
ctttaagata tgtagtatca gatatactaa aggaaagtcg ttatcaatat actaaattta 27600
atcaacctaa atcaaaattt gaaaacttac ctcaaaaatt acttcttaaa agggaagatg 27660
ttattgtact acaagaccct tataaagtta atgatggtat agaagaagac ctagaaattc 27720
aagtagatga ccctaaagct tccgcatcta atcctagtaa tttaggtgga ttcttcggag 27780
gtgcatttaa ataatgccag ttcacggaaa gagacctaat ttatttaaaa ataaaaacta 27840
taagcaggta ggtaagagaa ccattgatgg catgcgttca gaagttcttg acaagctaca 27900
agcaacagca cagcaagtag agaatactag tattaaacgt atgcctactt atctacaagt 27960
aacagagaaa aagcttgaaa aagaaggagt agtagacctt aaaaaagcat ttgctcactc 28020
atctaaaaag aaaactagta aagacggagg atggtattta actgtaccaa tccgcattaa 28080
aactagtaga atgaacaaca gtacttatca agatatgagg actttaaaag tagataaagg 28140
cacaggttca gtttctaaga taactgatta tctagaagga cgtagaaaga atgtaagtca 28200
cccgtcaatg aaaccggaac ctatgactca taacatgact aaagttaaaa gaggaaagca 28260
atcttcttac tttatattta gaactgtttc tagtaaatca cctgctagtt cctggatact 28320
taatagagat aaagttaatg agaataattt ctctaaaaca actctaaaaa ctgttaagca 28380
actaatgaac tggaagatga aaaatttaaa ttaagaggag ggttagtatt aaatggcaat 28440
aacatcagtt gattcatatt tattatcaga aataaagcct agacttaaca ctgtgctaga 28500
gaattgttat attatagatg aagttttaaa agactttgat tatcaaacta gagagagctt 28560
taaagaagct ttctgcggta agaatgcaca acatgaagta acggtaggat ttaacttccc 28620
aaaatttaaa aataactatg aagctcatta cttgatacaa ttaggtcaag gacaagagac 28680
aaaaaactct ttagggagta ttcagtcatc ttactttgag gcaacaggag ataccttagt 28740
cgaatcttct acagcaataa gagaagatga taagttagtt tttactgttt ctaaacctat 28800
aggagaatta ataaaagtag aagatataga gtttgctaaa tacgataatc ttcaagttga 28860
aggtaataag gtatcattta agtaccaaac aaatgaagat tatgagaatt ataatgctaa 28920
tattatcttt actgaaaaga aaaatgattc aaaaggttta gtaaaaggat tcacagttga 28980
agaacaagta acagttgtag gtctatcatt taatgtagat gttgcacgat gtttagatgc 29040
tgtattaaaa atgattttaa tatctatgag agatagtata gaagagcaac aaacattcca 29100
attacagaat ttgtcctttg gtgatattgc accaataata gaagacggtg actcaatgat 29160
ttttgggaga ccaacaatta ttaagtacac aagttctcta gacttggatt atactattac 29220
acaagatatt aataaactaa cttttaaaga aagaaaggat tggaagtagg atggctagaa 29280
aaaagacacc tgaaaataac actcctaaat ttaatggtta tgttcatata gatacattcc 29340
ttgatactgc aaaaaccctt tttaatatga gggattcaca agtagcagga tttaaagctt 29400
atatggaagg tagtcattat ttgtttagtg agcaagaatt cttaccctca ttagagaagt 29460
acttaggtag gaaattagat atataataac attcagataa ggagaattaa atatggcagt 29520
agaaccattc ccaagaagac ctattacccg ccctcatgca tctattgaag tagatacttc 29580
aggtatcggt ggctcagcag gttcaagtga aaaagtattt tgcttaatcg gttcagcaga 29640
aggcggagaa ccaaatacag tttatgaatt acgtaactat gcacaagcta aacgtttatt 29700
ccgttcagga gaattacttg atgcaattga attagcatgg ggctctaacc ctaactatac 29760
agcaggtaag attttagcta tgcgtactga agatgctaaa cctgcttcag tagaagctgg 29820
cggattaaaa ataacatctc aaatctacgg taatgttgct aataacattc aagtaggatt 29880
ggaaaaaaat acattaagtg attcattacg tttaagagta attttccaag atgaccgttt 29940
caatgaagtt tacgataata tcggtaatat cttcacaatc aagtacaaag gagaagaagc 30000
taacgcaact ttctctgtag aacatgatga agaaactcaa aaagcaagtc gtttggtatt 30060
aaaagtcgga gaccaagaag ttaaatcata tgacttaact agcggtgctt atgactatac 30120
taacgctatt attacagaca ttaatcaatt acctgatttt gaagctaagt tatcaccttt 30180
cggagataaa aacttagaat ctagtaaatt agataaagca tcagatgtaa atattaaaga 30240
taaagctgta tatgttaaag cagttttcgg tgacttagaa aaacaaacag cttataatgg 30300
tattgtatct tttgagcaac ttaatgcaga cggagaagta ccaagtaatg tagaggttga 30360
agcaggagaa gaatcagcta cagtaacagc tacttcacct attagaacta ttgagccgtt 30420
cgaattaact aagttaaaag gcggtactaa cggtgaacca cctgctacat gggcagataa 30480
attagagaaa tttgcacatg aaggcggata ctacattgtc ccattatcat ctaaacaatc 30540
agttcatgca gaggtatctg ctttcgttaa agaacgttct gatgcaggag aaccaatgag 30600
agctattgtt ggtggaggat ttaatgaatc taaagaacaa ttgttcggta gacaagcatc 30660
attatctaat cctcgtgtat cattagtagc taactcaggt acttttgtta tggatgatgg 30720
acgtaaaaac catgtacctg cttatatggt agctgtagct ttaggtggtc ttgcaagtgg 30780
tttagaaatt ggtgaatcaa tcactttcaa accattacgt gtaagttcat tagaccaagt 30840
atacgagtca attgatttag atgaattaaa tgaaaatggt attattagta tcgagtttgt 30900
tcgtaaccgt actaatacat tcttcagaat cgttgatgac gtaactacat tcaacgataa 30960
gtcagaccca gttaaggctg agatggctgt tggggaagct aatgacttct tagtaagtga 31020
gcttaaagtt caacttgaag accaattcat tggtactcgt actatcaata caagtgcttc 31080
aatcattaaa gactttatcc aatcttactt gggtcgtaag aaacgtgata atgaaattca 31140
agacttccct gctgaagacg tacaagttat tgttgaaggt aacgaagcaa gaatttcaat 31200
gacagtttac ccaatcagaa gcttcaagaa aatctctgtt agcttggttt acaagcaaca 31260
aacattacaa gcctaatcta ggtgatggag tacctagatt gggtactcct attaatataa 31320
tttgaatact ttaggagagt gaatacagat ggcatcagaa gctaaacaaa ccgtccatac 31380
tggtaatacc gtcttactta tgattaaagg taaaccggta ggaagagcac aatcagcatc 31440
aggtactcgt gaatacggta caactggtgt atacgaaatc ggttctatca tgcctcaaga 31500
acacgtatac ttacgttatg agggtacaat tacagtagaa cgtttacgta tgaaaaaaga 31560
aaactttgca gatttaggat atgcttcact tggtgaagaa attcttaaga aagatatcat 31620
tgatatttta gtagtagata acttaacgaa acaagttatc atcagttacc acggatgtag 31680
tgccaataaa taattgttgc ttctatacag taatgtatag tcgaataata cctgaaattg 31740
cgggaacacc ttaaagccaa ttaaactaca acgtaacttg aaagagtaag cgtgaatgtt 31800
gagaaatcag aaaaaattaa ttggatagta tatggtgaga taaaagcatt aataactaac 31860
gacacattat taatgtccta agtactcaat caataggaaa tccgcaggca agcctacgag 31920
agtaggaagc ttcaacgact gtaataggta gtcaccttag aaataaggga catgggacag 31980
tctaacccct ttaaaatata tcgaaagata gggtataagt gaactataat gagacgtggc 32040
agacaaatga aattgtaaca gaagaaattg agtttagtta cctttaacta atagaggcta 32100
tgtttggtga caagcataga aaacacttta aattgcgtga aagtcttaaa gactagataa 32160
ctacaaagta acctgaaagg gtaagcttga atgttgagaa atcagaaaaa atatctagta 32220
tagtataagg ttaaacccta agtacagtaa aatagatgat acgcaggcaa gcctacgaga 32280
gtgggaagct tcaacgacta taataagtga gtcttagtta cacattaaga ttatggtata 32340
gtctactccc tttaaaatat atcgaaagat agggtataga ggacagcatc agataaggct 32400
agaacttaaa tttcctatta agacctaaca ataaaagtta ggtctttttt ttattgacaa 32460
agtgtaaaag ttatggtaca cttatgatat attaataata ggaaggtgat atcaatgata 32520
tattcaaata aagtactagg ttctcatggg gaacgattag tagattcaat tttaggtttt 32580
aataatatga agtataaacg agagtatcct tttaagaata atatcggtac aaaacaaaga 32640
atggattttt tagtagaata ccaaggaaaa ttttattgta ttgaatatat gggtgagcaa 32700
cattatagac aagtattcaa tttagatttt gatagaataa aattacttga tagaattaaa 32760
aaagaatatt gcgataacaa taatataatt tatatagata taagttataa aaataaaacc 32820
ttagagcaag tatatcaaat tttaagaaac tattttacag aaattaagaa acctgataca 32880
gtagaagtgt acactacttc tttaaaattt aatggtgata ttaatgtcta cacaaagaat 32940
gggcgttacc tatacacagg tagttataat gatattatca ataagtataa acttactgat 33000
agtaattttt ataaatgttt aatcggagaa ttaaattcca catcaggata taagttcagc 33060
ttagttaatg aagaacagga attagaaaga aagacttatg tagagtcaag aagaattaaa 33120
agagaagaaa gtatcaagag agcaccaaga aaaacaacac caatagctat gtatgattta 33180
gataaaaatg aagaaactat atttaagtcc attaaagagt gtgaaattga aacagggata 33240
aaaggaatat cttcctactt atatggtgat attgacagac ttactttgag taataaaatg 33300
tttagactag tagatgaaga atacaaatat acaccggaag aagcacgtaa aagaagtcaa 33360
aagaaaatga ttaaaggaac tcatatggtt acaggtgaaa cagttgaagg tactgttaat 33420
gaagtagcta gattaattaa tgcatcagca ccaaatataa gtaaagtttt aaaaggtaaa 33480
agtaagcatt gtaaaaagta taaatttatt tacctataac ccttgaccaa tatcaagggt 33540
tatgatatta taaaaatgta aggagagagg tacatgaata atagacaatc taaaataaaa 33600
ggttataatc aatttcatta ctatgatttt ccaacaacta aaggtaagtt taaagatata 33660
atgaaaagaa aatctagaac agaacttaaa aaatatttac aaaaagagag ggaagattat 33720
cttgacaaat agaaaaacaa ttggtaagat gagtaagaca cgagcaacat ggaatattaa 33780
ccctgtaact aaagttaaga aagataaaac taaatattct agaaaaaata aacataaagg 33840
tcttgacaat tataattaga tacagtatac taagattata acaaataagg agatggatta 33900
tatgagtaca ttttggtcaa aaagaagaac aaccggtaaa gacaggcaag taaagaaaca 33960
ttatactcaa atgtctttac aagaaaagaa gcagtgtgtt aaactattac aagatacaat 34020
taatacacat aaatatttag aactatcaag ccattgcaaa actaaaatta aaaatgaaat 34080
caattttagt aagttagtag gatttatatt taaaagtaat aatgcacctt ttaatgttat 34140
tgaatttaat attacagatt ttcatggtaa aaaacaaaga aggattattt ttaagagtcc 34200
tactattgta actatagaag aagtaagtag ttatcagtac ttagttatta acctagaaga 34260
cggtaaaata ataactacat actataatgg cattacagat acacacaaaa cattagattt 34320
agattattat gataaaggct tgacaattaa ataaggagga gttataatgg gattaacaat 34380
agtaaatagt tattttattc tatcaagtat tatatttatt gtattaagta tattaaatgg 34440
tagaggtaca gttacaaatg aatcactagc tatgagtaaa gcattaatgg taataacatc 34500
agctcaattt ttagcatttt taattattaa tggtgtttat tactcattaa aatatatgta 34560
ataagaagga gtacaaatga aaatatacat tgtaatagat ttaagaggga gtacagaaga 34620
agaaacaaat atggatttta aagcttttag ggaattacaa gatgctatag aatatgtaga 34680
tggtaatagt aataaagatt tacatataat gcctctagaa ttagaataaa agtattgaca 34740
aattaaaaat aataaattat aataaagata taacaaatta aaggagaaga tataaaatga 34800
cacaaagtaa attaagagca gtacacacag aaatgaaagt agaattacaa aaattcccgc 34860
aagaggtaga tgtaacaagt aaatcaactg caattgcaat caatcaaatt ttagacagat 34920
tcaaaacatt aactgaacaa gcaggtaaga ttactaagaa atatttagaa ggtcaagaaa 34980
tattaactat tgattatgag tattatgatt cattacaaga atactacatt tatttactaa 35040
gaaatagtga taaaattaaa caaagtttag aggaaatttt aacaagcaca gagaaatact 35100
taaagtaatt ttgatttaaa aacaaaatat gatatactat atttaaagta gtaagcctac 35160
actagtccgt gttatattaa tattgaatcg gataagcgta ggctttatta atatttaaaa 35220
aaggaaggta tatcatatta tggctgaaga aattaaaaag gaacaagatg tacaagaaac 35280
aaaagaagag aaaaaagatg ttagtaaaat gacacctgaa gagatagatg aattaaaata 35340
ccaagatagg aaagaaaaag aaaaagttat taacaaagtt attaaaggtg ttaatgatac 35400
ttgggaaaaa gaatataact ttgaagaatt agacttacaa tttaaagtta aaattaaatt 35460
acctaatgca cgagagcaag gtaatatctt tgcgttacgt tctgcttact taggtggtat 35520
ggatatgtat caaacagacc aagtaattag agcttatcaa atgctagcta cattacaaga 35580
agtaggtatt gaagttccta aggaattcca agaccctgag gacatctata acttatatcc 35640
tttaactgtt atgtatgaag attggttagg attcttaaac tcctttcgtt actaatagta 35700
tagaaacatt agataaagat atagaacgat tgggtggtat ggaatcaatt gttaaacaac 35760
ctttatctag aaatctatgg gctattatga aagagtttaa tgttttgcct actgagcaaa 35820
gatttaagga tttagacgat tatcaaatag agtttattat tggtaatatg aatagagatg 35880
tttatgaaca taataaacaa cttaaacaag ctcaaaaagg tggaaaattc gatagtcaat 35940
ttgaagatga cgatagtagt tggtggaatg aatctcatga agactttgac ccggtacctg 36000
atttcttaga tgccgatgac ttagcacaac agatggaagc taaattatct gatagagata 36060
aggaagaaag agctaagaga aatgatgcag agttaaatga tgaaacagaa ggactcacta 36120
cacaacatct tgctatgatg gaatacatta gaagaaaaca agaagaatta gatgatgaag 36180
taggaaatgg taaaactagt gaagatgatg ctactataac acaagagagc gttaataaag 36240
cactagaaga cctagatgat gactggtata tgtaaagggt ggtaggtgat actaccatcc 36300
ttattttttt aaaatggatg gtgaataatg atggcaatga atgacgatta tagattggtc 36360
ttatccggtg atagttcgga tttagagaat agtctgaagg caatagaact ttatatggat 36420
tccctagaat ctaaaaatat tgatgcccct ttagacaatt tcttaaagaa attaaaagta 36480
attgctaaag aagttaaaaa tgtacagaac tcaatggata aacaagaagg taaatctgtc 36540
atatcttcta aagatatgga tgaatctatt aaatccactc aatctgctac aaagaatata 36600
aatgaattaa agaaagcctt agatgacctt caaaaagaaa atatatctaa aggtattgca 36660
cctgaccctg aagttgaaaa agcatatgct aagatgggta aagttgtaga tgaaactcaa 36720
gaaaaacttg agaaaatgtc ttcacaaaaa ataggctcag acgctagtat acaaaataga 36780
attaaggaaa tgaaaacctt aaatcaagta acagaagaat ataataagat aagtaaagat 36840
tctagtgcta ctaaagacta tactaaacgt ttaagagcta atcgtaatat gactagaggg 36900
tatatggagc gttcagaagg aacaggacgt ttaacatatg accaaggggc acgagttaga 36960
agtgaactag gtaagatagg ttcttatgaa agtcaaagaa aacaaaatca acgcaactta 37020
ggtcaagcaa gagaacaata tagtaattat agaaaccaac aacaagacct gactaaacgt 37080
agagctagtg gtcaaataaa taaagctcag tatgaacaag aattagcttc tattaagcag 37140
gaaatgaaag ctagagaaga acttatatct aactatgaga aattaggagc agagcttgat 37200
aaaactgttc aatactataa aggttcagtt cagaaagatt tccaatctag agatgtagac 37260
caacaacgag gaacatttgg tagaatggtt caagagcgtt taccatctat cggttctcat 37320
gctatgatgg gaactacagc tatggctacg ggtttataca tgaaaggtgc ttcattaagt 37380
gaaactaata gaccaatggt tacatcacta ggtcaaaact cagataatat ggatatagat 37440
tctgtaagaa atgcatatgg agacttgtca attgataaca aattaggtta taatagtact 37500
gacatgttga aaatggctac ttcatatgaa gcatctgtag gacataaaag tgatgaggat 37560
acaatggcag gaactaaaca acttgctatt ggaggacgtt ctttaggtat taaagaccaa 37620
gaagcttatc aagagtctat gggtcagata atgcatactg gtggagtaaa ttccgataac 37680
atgaaggaga tgcaagatgc attcctaggc gggattaaac aatcaggtat ggttggtcgt 37740
caagatgaac aacttaaagc attaggttct atagctgaac aatcaggaga aggaagaact 37800
ttaactaaag accaaatgag taatcttact gctatgcaat ctacttttgc agagtcagga 37860
agtaaaggat tacaaggtga acaaggtgcc aatgctatta atagtataga ccaaggactt 37920
aaaaatggta tgaatagttc ttatgctcgt atagcaatgg gatggggaac acagtaccaa 37980
ggtcttgaag gtggatatga tttacaaaaa cgtatggatg aaggtatatc taaccctgaa 38040
aacttgacag acatggctga tatggctact caaatgggtg gtagtgaaaa agaacaaaaa 38100
tacctattca atagaagtat gaaagaaata ggtgctaact taactatgga gcaatctgat 38160
gagatattta aagatgctca atccggaaaa ttatctaaag aagagttagc taaaaaagct 38220
aagaaaatgg aaaaagaagg taaaaaagaa ggagaagata acgccactga ttataaagaa 38280
tctaaatcag gaaaaaatga ccaaaataaa tctaagactg atgataaggc agaagatact 38340
tatgatatgg ctcaaccatt aagagatgct catagtgctt tagcagggct acctgctcct 38400
atatatttag caataggagc tattggagca tttacagcat cactaattgc atctgcaagt 38460
caatttgggg caggtcattt aataggtaaa ggagctaaag gacttagaaa taaatttggc 38520
agaaataagg gtggtagctc cggaggtaac cctatggcag gaggaatgcc tactggagga 38580
ggttcaccta aaggcggagg ctctcctaaa ggtggcggta ctcgttctac tggaggtaaa 38640
atacttgata gtgctaaagg attaggagga ttcctagtcg gtggagcagg atggaaaggt 38700
atgtttggtg gagaatctaa aggtaaagga tttaaacaaa catctaaaga agcctggtca 38760
ggtactagaa aagtatttaa cagagacaat ggtagaaaag ccatggataa atctaaagat 38820
atagctaaag gtactggtag cggtcttaaa gatatttata atgatagtat atttggaaaa 38880
gaaagaagac aaaatctagg agataaagct aaaggttttg gtggaaaagc taaaggtctc 38940
tatggtaaat ttgctgataa gtttggtgat ggtggtaaaa atggtatcct ttcacaatca 39000
ccaaaagcag gcggtagcgg gctaggaaaa ctaggaaaac ttgcaggtgg acttggaaaa 39060
ggagccggag ttttaggtgt tgctacatct gccttatcat tgatacctgc tttagcttcc 39120
ggtgatagta aagctatcgg cggaggtata ggctctatgg gcggaggaat ggcaggtgca 39180
tcagcaggag cttctattgg agctttattt ggtggtgtag gtgcaatacc tggagcttta 39240
ataggcggag ctataggttc ttttggtgga ggagctgttg gtgaaaaagt cggagacatg 39300
gctaagaagg ctaacactaa agaaggatgg aacctaggat ggactaatgg agataaagac 39360
ggtaagaata aattccaaga ttctttatta ggaaaaccta tatctaaagc atggagcggt 39420
ataacaggtc tctttgataa tgacgctgaa gcatctgaag aagatagcaa agataagaaa 39480
aaaggcgtta aaggtgttaa aggagatact aagaagaaag aaaaaatgac agcagaacaa 39540
cttagagaaa agaataacca atctgaaact aagaatctta aaatctatag tgatttactt 39600
gatagggctc agaaaattat tgagagtgct aaaggtatta atatagatgg aggaacttct 39660
gatagtggtt ctgatagcgg aggctctgca tctgatgtag gtggagaagg cgcagagaaa 39720
atgtataagt tccttaaagg aaaaggacta tctgacaatc aggtaggagc tgttatgggg 39780
aacttacaac aagaatctaa tcttgaccct aatgctaaga atgcctctag tggtgcattt 39840
ggtattgctc agtggttagg ggctagaaaa acaggattag aaaactttgc taaatctaaa 39900
ggtaaaaaat ctagtgacat ggatgttcaa ttagattacc tatggaaaga gatgcagtct 39960
gattatgaaa gtaataatct taaaaatgcc ggatggagta aaggcggaag cttagaacag 40020
aatacaaaag catttgctac cggatttgaa cgtatgggag caaacgaggc tatgatgggt 40080
actcgtgtta acaatgctaa agaattcaag aagaaatacg gaggctccgg tggcggagga 40140
ggtggaggag ctctatcctc tacttaccaa gaagctatga gtaaccctgt attaactact 40200
ggttctaact ataaaggctc taatgatgct tctaatgctt ctacaactaa tagaataaca 40260
gttaatgtta acgttcaagg tggaaataat cctgaagaaa ctggagacat tatcggagga 40320
agaattagag aagttctaga cagcaacatg gatatttttg caaatgaaca taagagaagt 40380
tactagtaat tttgtattga cacaagagta gtatcatagt atactactct tatacatata 40440
aaaataaaag gaagtatgtg tatatgaaaa gattaagaag acctaaggta agaatagaga 40500
tagttacaga tgataataca tttacattaa gatttgaaga tacacgtgac tacaatggtg 40560
atgagttcgg agctaaactt ttaggtttcc aaactaaaaa ctctatggaa gatgatagtt 40620
ctgtattcca aatcaatatg gcaggagata cttactggga taagttagtt atggctaacg 40680
atataatcag aatatttatt acacctaatg atgaccctaa tgataaagaa ggtcgtcaag 40740
aacgtttaat ccaagtaggt atggtatcac aagtatcaaa agtaggtagt tatggtaatg 40800
accaaactca atttaggata acaggtcaat cttttgtaaa accttttatg aaatttggat 40860
taggagttat tcaggaagtt caagctgtat tacctgaagt aggttggctt attgatggtg 40920
acggagataa tgaagtaaaa tttactggta gctcagccca tgaagtaatg acaggaatta 40980
tacgtagatt cataccatat atgaagtata actatactga aaaaacatat aatacaattg 41040
ataactatct tgattatgat gatttaagta gttgggatga atttgaaaat ttgacagaag 41100
tatctgcttt tactaatttt gatggctcat taaaacagtt gatggatatg gtaacagcta 41160
gaccctttaa tgaattgttc ttcaaaaact ctgaaaaaac acctggtaaa gcacaacttg 41220
tattaagaaa aacccctttt aatcctactg agtggagagc tttagatatg attaaagtac 41280
ctactgaaga ctttattgaa gaagatgtag gtaaaagtga cgtagagaca tattctatat 41340
ttacagctac acctgcaggt atgttaaaag aacttaatgg tgatgtattt tctaaaccac 41400
aatttcaccc tgaattgact gatagatatg ggtatactaa atttgaagta gaaaatatct 41460
atcttagtac taaatcaggt tcagctactg aagactcaga ttcttcgggt gatgacaatg 41520
gtactgaaag aggaacttac tctaaaatta tgaaagattt aagtaactat ggaagagata 41580
atatatctaa aggtatagat aagtatacaa gtaaattatc ttcaaaatat aaaaacttaa 41640
aaaaagctca agctaaaaaa attatagaga aatttgtcaa agaaggaaaa gtaacagaaa 41700
aagaatacga gaagataaca ggtaataaag tagatgatga attaacatca gataacagac 41760
cgaagttgac aaaggataaa ttaaagagta tactaaaaga gaagtttaaa acacaagatg 41820
attttaataa ctctaagaaa aagaaaaaag ctaagacaga tgcacttaaa gaattgacaa 41880
ctaaatatcg tttcggtaac aaaacacacg ctacaacttt gttagatgaa tatattaaat 41940
acaaaggaga accaccgaat gatgaagctt ttgataaata tcttaaagct attgaaggtg 42000
ttagtaacgt agctacagac acaggttcag atgcaagtga tagtccttta gttatgttct 42060
ctagaatgct atttaattgg tatcatggga accctaactt ctacgcagga gatattattg 42120
ttttaggaga ccctaagtat gacctaggta aaaggttatt tattgaggat aaacaacggg 42180
gagatacttg ggaattctat attgagtctg tagaacataa atttgattat aaacaaggtt 42240
attatacaac tgtaggagta actagaggtt taaaagatgc tatcctagaa gatggtaagg 42300
gtagtcctca taggtttgca ggtttatgga atcaatcatc agacttcatg ggaggtctta 42360
tgggtgaaga tacttctaaa gaactcaaag aaaaaggtgt agcagagaag aaaagtagtg 42420
gagataaaga cggtggctct gatagtggtg gagcacaaga tggaggttct ctagattcac 42480
ttaaaaaata taatggtaaa cttcctaaac atgacccaag tttcgttcag cccggtaacc 42540
gacattacaa gtatcaatgt acttggtatg cttataatag aagaggtcaa ttaggcattc 42600
ctgtgccttt atggggggat gccgccgact ggattggtgg tgctaaaagt gcaggatatg 42660
gagtaggtaa gacaccaaaa caaggtgcct gtgttatttg gcaacgagga gacaaaggtg 42720
gttctaatgc ttatggtcac gttgcctttg tggaaaaagt tttagatggt gggaagaaaa 42780
tattcatttc tgaacataac tgggctacgc ctaatggtta tggtactaga acaatagaca 42840
tgagctctca aataggtaaa gaagctcaat tcatttacga taagaaataa aggaggatag 42900
tctatggcaa cagataaaga agctaaagat gttattgata aatttataga taatgtgttt 42960
aattttgatg tattaactac ggaaagagtt aaagaaaaag atgaagaaat caaaaaaata 43020
actacagatg atatgtatga aaaagttgtg tatatacgac cttatgttgg agtaatacaa 43080
agtcttaacc ctcaacatgt acaatatgaa tcattttcta ataatggtta cgatatagaa 43140
gcagaattaa gttttaggaa agtaagttat ttagttgata aagggtctat acctacagat 43200
tctttatcca ctttaacagt tcacttagta gaaagaaatc aggagttatt aatagattac 43260
tttgatgaga tacaagatgt gttgtatggg gagtatatgg aagaagaata tgtatttgat 43320
gaagatgtac cattaagtac tatactagca ttagacttaa atgataatct taaatcctta 43380
tcaaatataa agtatatgtt caaaggagcc cctaaagata atccttttgg aacagataaa 43440
gatgtttata tagatactta taatttatta tattggttgt atttaggtga agatgaagaa 43500
ttagcatatc ctatgaatat taactatttc tttacagaag gtagattttt tactgttttt 43560
ggtaaaggtc ataagtataa agtagatgtt agtaaattta tagttggaga tatattattc 43620
tttggtagaa gtgatactaa tataggtatt tatgtaggtg atggagagtt tatatctatg 43680
ataggtaaat ttccaaaaga tgagacacct ataggaaaat acaaacttga tgattactgg 43740
aatgaattta acggaagagt tatgagattc gatgaagagg tgtatattta atggtagtaa 43800
gattccaatc ttccatgggg agaagtctaa aaagagtaga ttcagatgac ttaaatgtaa 43860
aagggttagt tttagctaca gttagtaaaa ttaattataa gtatcaatca gtagaagtta 43920
aagttaataa cttgacttta ggaagccgta taggtgatga tggtagctta gctgtacctt 43980
atcctaaatc tttcataggt agaacacctg agggaagcgt attcggtaca aaaccactta 44040
ttactgaagg ttctgtagta ttaatagggt tcctaaatga tgatataaat agtcctataa 44100
tcttgagtgt ttatggtgat aatgaacaaa ataaaatgat taatactaac cccttagatg 44160
gaggtaagtt tgatacagaa agtgtttaca aatacagtag ttcactatat gaaattttac 44220
catctttaaa ttataaatat gatgatggag aagggacaag tattagaact tataatggta 44280
aatcattctt ctctatgaca tcaggtgaag aagagaaacc gcaggcaaca gatttttata 44340
ctggaactga gtatcaagat ttatttactt cctattatgg taataaaaca ttgattgaac 44400
ctagaataca aaaggctcct aatatgttat tcaaacatca aggagttttt tatgatgatg 44460
gcacgccgga taatcacata actactttat ttatatctga aagaggagat atcagagctt 44520
cagttttaaa tacagaaaca cagaaaagaa ctacacaaga aatgtcaagt gatggttctt 44580
atagggttat taaacaggat gacgatttaa tgttggatga ggctcaagtt tggattgaat 44640
atggtattag tgaagataat aaattttata ttaaaaatga taagcataaa tttgaattta 44700
ctgatgaagg aatttatata gacgataagc ctatgctaga aaatttagat gagagtatag 44760
cagaggctat gaagaattta aatgaaatac aaaaagaact agatgatata aactatcttc 44820
ttgagggtgt aggtaaggat aatttagaag aactaataga atccacaaaa gagtctatag 44880
aagcgtctaa aaaagcaact tcagatgtta atagacttac aactcagata tcagaggtta 44940
gtggtagaac tgagggtatt ataactcaat tccaaaaatt tagagatgag acttttaaag 45000
acttttatga agatgcttct actgttatta atgaagtaaa tcagaatttc cctagtatga 45060
aaacagatgt taataatcta aaaactaaag ttaataactt agagaaaact gagataccaa 45120
atatcaaaaa taggttaaca gaactagaga ataataataa caatgcagat aaaataattt 45180
cagatagagg agagcatata ggtgctatga tacagttaga ggaaaatgtt actgtaccaa 45240
tgagaaaata tatgccaata ccttggagta aagttactta taataatgct gagttttggg 45300
attctaataa ccctactaga ttagtagtac ctaagggaat aacaaaagta agagttgcag 45360
gtaatgtcct atgggattct aacgctacag gacaacgtat gttgagaata ttgaaaaatg 45420
gtacttatag tttagggtta ccttatacaa gggatgtagc tatatctacc gcacctcaga 45480
atggtactag tggagttatt cctgttaaag aaggagacta ctttgagttt gaggcttttc 45540
aagattcaga aggtgacaga caattcagag cagaccctta tacatggttt agtattgaag 45600
ctatagaatt agaaactgaa accatggaga aagactttat gcttataggt cataggggag 45660
caactggata tacagatgaa catacaataa aagggtatca aatggcttta gataaaggtg 45720
cagattatat agaattggat ttacaattaa caaaagataa taagttattg tgtatgcatg 45780
attctactat agatagaaca acaacaggaa caggtaaggt aggggatatg actttatctt 45840
atatacaaac taactttaca tctcttaatg gtgagcctat accatctctt gatgatgtat 45900
taaatcattt tggaacaaaa gttaaatact atatagaaac taaacgtcct tttgatgcta 45960
atatggataa agaattatta actcagttaa aatcaaaagg attaatagga attggttcag 46020
aaagattcca agtaattatt caatcatttg ctagggaatc attaattaat attcataacc 46080
aattttctaa tataccttta gcttatttaa caagtacatt ctctgaaagt gaaatggatg 46140
attgtttaag ttatggttct tatgctattg ctcctaaata tacaacgata actaaagagt 46200
tagtagattt agcgcatagc aaagggctta aagtacatgc atggacggta aatacaaaag 46260
aagaaatgca aagtttaata caaatgggtg tagatggatt ctttacaaat tacctagatg 46320
aatataaaaa gatttaatat taaagaccta ttaatttagg tcttttttta gttgtaattt 46380
aaactagttc gtgatatatt agtagtatga gatttatata catactgaaa aggagaggat 46440
aaaatgccac aatcagatgg aataagtaat cttcatagaa tagctttacg cttccctaaa 46500
gaaggcggtg gttatgatat gtataggttt aaagttaatc ctgagaatta cacaatagat 46560
tcaccacaac gtacgacagc aattaaaaca aaatcagata ttgtaataga agattatggt 46620
aaagacatag aagttattaa cttcacaggt acaactggtt ttagacctgt tagagaagca 46680
gatggattaa aaacaggtaa gcagaagatg gaagagttac agagtagagt tagtgaatat 46740
gctatgcaag gtggtagtgg taacgtaagt ggctcttatt tacaattttt taactttaca 46800
gatgatagct actataaagt tcatttagcc cctcaagggt taaaggtaac taggtctaag 46860
gatgaaccgt tactttttag atatgaaata acattagtag tcatcggttc attaacagaa 46920
gcagatagaa gtgctgtaac aacagaagag tttggtaatg ttaaacctaa cgcttctcaa 46980
agagtagatg aaggcataaa agaactagat aaaaatgctc gtaaaacgag agatagaaat 47040
aaccaagaaa tatctagaag agaaaataca atacctaaat ctacaggaga taatacaaac 47100
gagggtaata ggttaaagca aagtttccct agtagttcta tatataatcc tagacaatct 47160
actaatggat taaaaggtaa tattgacaat atggctttaa taatcggtta tggtgatgga 47220
ggtgtatcta gctaatgaat aattttatac cacaacctca agggttactt aggtttttaa 47280
acgccctaga tacagattta acttcttctc atatgaattt acttgatgaa gaggtatcat 47340
ttgtatctaa attttataca ccgcaattac aattaagtga attagcaaaa aaagtattga 47400
caaatataaa gacagatgat atacctgtat tagaaagaga atttaatgac aatacaatta 47460
ttcataaagc taacgataca ttactaaaag tacaagcccc tagaatgtat atgattctac 47520
aatctattgt acttgaagcg tatgctattg ttaattgctt tgtagaaaat ccaagttctt 47580
taaaatatct aactgaagaa gatgttagaa taacacgaga aaatttaaat tatgtagcag 47640
actatttagg taactatgat gattacaata gtgttgtctt agatttacga gacctagatt 47700
tatgttttag tgctatagag ttacaattac ctctaattaa aaaggaggct aacgtataat 47760
gagatttaag aagcatgttg ttcaacatga agaaactatg caagcaatag cacagagata 47820
ctatggtgat gttagttatt ggatagacct agtagaacat aataacttaa agtatcctta 47880
cctagtagaa actgatgaag aaaaaatgaa agaccctgaa aggctagctt ctacaggtga 47940
tacattgatt atacctattg aatcagactt aacagatgta tcagcaaagg aaattaattc 48000
tagagataaa gatgtattag ttgagttagc tttaggaaga gatttaaata ttactgcaga 48060
tgaaaagtat tttaatgaac acggtactag tgataacata ctggcattta gtacaaatgg 48120
taatggggat ttagatactg taaaaggcat agataatatg aaacagcagt tacaagcacg 48180
tttattaact cctagaggtt ctttaatgtt acaccctaac tatggctcag atttgcataa 48240
tttatttggt cttaatatac ctgaacaagc tacattaata gaaatggaag tattgagaac 48300
attaacatca gataatagag taaaatctgc taatctaatt gattggaaaa tacaaggtaa 48360
tgtttattca ggtcaatttt cagtggaaat aaaatctgtt gaagaatcaa taaattttgt 48420
tttaggacaa gatgaggaag gaatttttgc tttatttgaa taggaaagga ttaaattatg 48480
aaaactagaa aattaactaa catattatca aaattaatag ataagacaat ggcaggtaca 48540
agtaagataa cagattttac ccctggttca gcctctaggt cattattaga agctgtatca 48600
ttagagatag agcaatttta tatcttgaca aaagaaaata ttgattgggg tatacaagaa 48660
ggtattattg aagcttttga tttccaaaag agacaatcta aaagagctta tggtgatgtt 48720
atcattcaat tttatcaacc tttagatatg agaatgtata tacctgcagg aacaactttt 48780
acttcaacac gacaagaata ccctcagcaa tttgaaacat tagttgatta ttatgcagag 48840
cctgactcta ctgagattgt tgttgaggtt tattgtaaag aaacaggagt tgcaggtaat 48900
gttcctgaag gaacaattaa tactatagca tcaggttcta gtttgattag aagtgttaat 48960
aatgagtatt cttttaatac aggaactaaa gaagaaagcc aagaagactt taaacgtaga 49020
tttcactctt ttgtagaatc tagaggtaga gcaactaata aatcggtaag atatggagca 49080
ttgcagatac ctgatgtaga aggtgtttat gtttatgaag aaacaggaca tattacagta 49140
tttgcacatg atagaaatgg taatttatca gatactttaa aagaagatat aattgatgct 49200
ttacaagact atagaccgag tggtataatg ttagatgtta caggtgtaga aaaagaagaa 49260
gttaatgttt ctgctacagt aactatatct aataaatcta gaattggtga tacattgcaa 49320
aaacatattg aaggtgttat tagaagctac ttaaataatt taaaaacttc tgatgacctg 49380
ataattacag accttattca agctataatg aatattgatg atgtattaat atatgatgta 49440
tcgtttgaga acttagatga gaacattata gtaccaccac aaggaattat tagagcagga 49500
gaaataaaag tagaattaaa gtaaagagag gtgaaactta agtcgtggct aattttttaa 49560
agaatcttca tccattatta agaagagata gaaataaaaa agataatcaa gaccctaact 49620
ttgctctgat agatgcactc aatgaagaga tgaatcaagt agagaaagat gctatagaaa 49680
gcaagttaca atcttctcta aagacagcaa cgagtgaata tttagacaaa tttggagatt 49740
ggtttggggt ttatagaaag accgatgaaa aagatgatgt ttatagagca agaattataa 49800
aatacttact cttgaaaaga ggaactaaca atgctataat agatgctata agagattatt 49860
taggtaagga tgatattgat gtaagcgtgt atgaaccctt taccaatatt ttctatacta 49920
acaaatcata cttaaatggt gaagaccatt taatgggata ctattataga tttgctgtta 49980
taaatgtttc tataggtgac tatttcccta tagagattat agatgtaatt aacgaattta 50040
aacctgcagg tgtaacatta tatgttactt atgatggagc ttctactatc agaggtggag 50100
caattattaa gtggttagat ggactaccta aaattgaaac atatcaagag tttgataggt 50160
ttacaggtta tgatgataca ttttatggtc atattaatat gaatcaaagt aaagatactg 50220
ataatagttc atcagacatt tttaaaacaa atcatagttt aattaatagt ttagatgttt 50280
taacaggttc ctctagtgta ggtagacaat atgttaacta tggatatgta acatcatatg 50340
tttataatcc aggtatgaca tcttctgtaa accaaataag tgctagtaca gaaggtagag 50400
gtcaggaagt acctactgat tattatatgt atactagtac caagaataat aatacagtag 50460
aacttaatat gcaaactact tccggtgtat cttatctcta taataacttt aattttagag 50520
attatatgag taagtataga cctcaagtag atttacaatc tgatgaggct agaagaattg 50580
tatctgatta tataaaagaa ttaagtattg attattatct cagtgctgtt atacctcctg 50640
acgaaagtat agaaattaaa ttacaagttt atgacttttc tattaataga tggcttacag 50700
tatcaattag taacttatct ttctatgaaa aaaatattgg tagcaatata ggttatataa 50760
aagattattt aaatagtgaa ttaaatatgt ttactagatt agagataaat gcaggtaaaa 50820
gagactcagt agatattaaa gttaactatc tagatttaat gttttattac tatgaacgag 50880
gaatttacac aataaaacct tataaagcat tagtagaaaa ttacttagat atatctagag 50940
agacttatgt agaggcgttt aaaatagcat cattattgaa tggagacatt ataactaaaa 51000
caggtttcca acctatagga tacttaaaat tagttggtag ttatgagaat acaagaccta 51060
gcgcagtaaa catagtagct aaagatacag ataataatcc tatagaatct actgagttag 51120
atgtgtatag tacaatagaa aacaggaatc tattacagtc ttataaaggt gtaaataata 51180
tagctagaga aataacatct acggaagagt ttaccgtatc aggatgggct aaagagatat 51240
attcaactaa ttatttgtct aaagtactaa aaccaggtaa agtatacact ttatctttcg 51300
atatggaaat aacaaataat gacctgactc ttaaatctta ttctgataat catggtatat 51360
atttatacag taataccaaa ggaattgttg ttaatggtgt taaatctatg gagcgcaccg 51420
taggtaacaa agtatctata actcagactt ttacagcacc tactattacc gaccacaggt 51480
tattaattta tactggaaga tatacatctg atgggaaagc atcaacccct ccagtgttct 51540
ttaatacagt taaaattact gaactaaaat tatctgaagg tgactctaaa ttagcttact 51600
cacctgcccc tgaagataaa cctaatgtaa tagaaaaagg aattcaattt aataatatca 51660
aaactaatat acagacttta aatatcaatt cagatattaa tctaaagaat gtaactttat 51720
actattctta ctatggtgat agttgggtag aattaaaaac tataggtaat attagtacag 51780
gagaaacaac agaaactaat aatttaatag atttatatgg attacagaca gtagattact 51840
ctaacataaa tccaatgtca aaagtatcat tacgttctat ttggaatgtt aaattaggtg 51900
aacttaataa tcaagaaggt tctttatcta atatgcctaa tgattatttt aatgctgtat 51960
ggcaagacat agataaacta tcagatattg atttaggttc tatgagaatg gtcaaagaca 52020
ctgaaggtgg agtatttgat ggagctacag gtgaaattat taaggctact ttatttaacg 52080
ttggtgttta tactgattta gatatgttag cttatacttt gactaattac actgaaccat 52140
taactttagg ttctagtaga ttgataagtg agctaaaaga agaattacta acatcagaat 52200
catttaatgt tgataataga attaaagtaa ttgactcaat ctctgagcaa ttacctaata 52260
ataatatatt gagtaactct tatcaaacac aaacgattac acagaatgga tttgctaaat 52320
ataatttgaa agaacctata gaacaaagaa aacaatacaa cctaagaata catggagatt 52380
ttaaagaagg actagaaaga ttagctatag gtaattctaa tgggtcattt aatgaagtat 52440
ttgtttatcc tgaaaatatt aaagatggta tagtagatat tacttatact tctagagatg 52500
ataattatgc agaaggaaaa caaagactta ataatgatta tagagtttat gctcaaccat 52560
atgatagtgg tgtagttaca atttacagtc tagagttaat aaaagtttaa taaataagtt 52620
gacagaaagt taataatatg gtatacttat aaagtaatat ttagtgggta taccatgtta 52680
tattaataaa gaaaacaaca gatgaaagga attaaaaaat atggcaattg caacgtataa 52740
ttctcatgtt gagttagcaa aatatctagt tagtaaagct gattcagttt acttaacaat 52800
tggaaagagc acaccgtggt ctaatgaaac aaacccaccg caacctgatg aaaatgcaac 52860
agtattacag gaggttattg gatacaaaaa agctactaaa gttactttag ttagaccttc 52920
taaatcacct gaagatgata ataagaattt aatttcttat ggtaataaat cgtgggtaga 52980
agtaacacct gaaaatgcta aggctgaagg agctaaatgg gtttatttag aaagtagtat 53040
tgttggtgac gaactacctc ttggaacata tagacaagta ggatttgtta tggacttagt 53100
agcaaaaagt ggtattagta aatttaactt agtaccgagt gaagtagaat caattggaac 53160
actattattc tttgacaata aacagttcca aaatagaagt gagcaaacaa ctgctaaaga 53220
aagatttatt gtagaagttt aaagaaaggg agataattct aaatggcaat taattttaaa 53280
ggttcacctt atttagatag atttgacccg tctaaagata gaacaaaagt attatttaat 53340
cctgatagac ctctacaaca ggcagaatta aatgaaatgc agtctataga ccaatattat 53400
ttaaaaaatc taggagacgc tatttttaaa gacggagata agcaatcagg acttggattc 53460
acattgtctg aagataatgt attgacagta aaccctggtt atgtatatat caacggtaaa 53520
ataagatatt acgataatga tgattcagtt aaaataactg gtgtaggtaa agaaactatc 53580
ggtattaagt taacagaacg tattgttaca cctgatgaag atgctagcct attagaccaa 53640
actagtgggg taccaagtta cttctccaaa ggtgcagata gattagaaga aaagatgtca 53700
ttaacagtta atgaccctac ttcagcaact atttatactt tcatggatgg agatttatat 53760
atccaatcaa ctaatgctga aatggataaa atcaataaag tattagctga acgtacttac 53820
gatgagtcag gttcatataa agtaaatggt tttgagttat tctcagaagg taacgctgag 53880
gatgatgacc acgtttctgt agttgtagat gcaggtaaag catacgtaaa aggttttaaa 53940
gtagataaac cagtatcaac aagaattagt gtacctaaat cttatgacct aggaacagca 54000
gaaaacgaaa gtactatatt taataagtct aataattcta ttagtttagc taatagccct 54060
gtaaaagaaa ttagacgtgt tacaggtcaa gtacttattg aaaaagaacg agttacaaga 54120
ggagctcaag gtgatggtca agactttctt tcaaataaca cagcatttga aattgtaaaa 54180
gtttggactg aaacaagtcc tggagttact acaaaagagt ataaacaagg agaagacttc 54240
agattaacag atggtcaaac tattgactgg tcacctcaag gtcaagaacc ttcaggcggt 54300
acctcatact atgtttctta taaatataat aaacgtatgg aagccggtaa agattatgaa 54360
gtaacaacac agggtgaagg gttaagtaag aaatggtaca ttaactttac accttcaaat 54420
ggagctaaac ctattgacca aacagtagta ttagtagact atacttacta cctggctcgt 54480
aaagattcag tgtttattaa taagtatggt gatattgcaa tactacctgg tgaacctaat 54540
attatgagat tagtgacacc accgttaaat acagaccctg agaatttaca attaggtacg 54600
gttacagtat tacctgattc agatgaagca gtatgtattt cgtttgcaat cactagattg 54660
tctatggaag acttacagaa agttaaaaca agagtagata acttagagta taaccaagca 54720
gtaaatgctc tagatgatgg tgctatggaa ggacagaacc ctttaacgct acgttcagta 54780
tttagtgaag gtttcattag tcttgacaaa gcagatatta cacatcctga cttcggaatt 54840
gtatttagtt ttgaagacgc agaagctact ctagcgtata cagaagcagt taaccaacct 54900
aagattatta ctggagatac aacagctcat atttggggta gattaatttc agcaccattt 54960
actgaggaac gtacaatcta tcaaggtcaa gcatcagaaa cattaaatgt taacccttat 55020
aatatcccta ataaacaagg tgtacttaag ttaacaccta gtgaggataa ctggattgat 55080
actgaaaatg ttacaataac tgaacaaaaa actaagaaag taactatgaa acgattttgg 55140
agacacaacg aaagttacta tggtgagact gaacattact tgtattctaa tttacaatta 55200
gatgcaggac aaaagtggaa aggtgaaact tacgcttacg atagagagca tggacgtact 55260
ggtactttat tagaatcagg aggacagcgt actctagaag aaatgattga attcattaga 55320
attagagatg tatccttcga ggttaaaggt ctaaacccta atgataataa cttatattta 55380
ttatttgatg gtgtaagatg ccctattacc cctgcaactg gttacagaaa aggttctgaa 55440
gatggaacta ttatgacaga tgcaaaagga acagctaaag gtaaatttac tattcctgca 55500
ggtattcgtt gtggtaaccg agaagttaca ctcaagaatg ctaactctac aagtgctaca 55560
acttacacag ctcaaggacg taaaaaaatc gttcaagata ttattattag aactcgtgta 55620
acagtaaact tagtagaccc attagcacaa tcattccagt atgatgagaa cagaactata 55680
tcatcactag ggttatactt tgcttctaaa ggtgataaac aatctaacgt tgttatccaa 55740
attagaggta tgggtgacca aggttatcct aataaaacaa tctatgcaga gacagttatg 55800
aatgcagatg acattaaagt atctaataat gctagtgctg aaactagagt atactttgat 55860
gaccctatga tggctgaagg cggtaaagaa tacgctattg ttattattac tgagaacagt 55920
gattatacaa tgtgggtagg tactagaact aagcctaaga ttgataaacc taatgaggtt 55980
atctcaggta acccatatct tcaaggtgtg ttattcagtt catcaaacgc atcaacatgg 56040
actcctcatc aaaactctga ccttaaattt ggtatctata cttctaaatt taatgaaaca 56100
gcaacaattg aattcgaacc aattaaagat gtatctgcag atagaatcgt tcttatgtct 56160
acgtacttaa ctcctgagag aacaggatgt acatgggaaa tgaaattaat tctagatgat 56220
atggcatctt ctacaacatt cgaccagttg aaatgggagc ctatcggtaa ctatcaagac 56280
ttagatgttt taggtctagc aagacaagtt aaactaagag caacttttga atcaaataga 56340
tatatctcac cattaatgag ttctagtgat ttaacattca ctacattctt aacagaatta 56400
acaggttcat atgttggtag agctattgat atgacagagg ctccttacaa tacaataaga 56460
tttagttatg aagctttctt acctaaaggt actaaagttg ttcctaagta ttctgcagac 56520
gatggaaaaa cttggaaaac atttactaaa tcccctacaa ctactagagc caataatgag 56580
tttacacgct atgtcattga cgagaaagta aaatcatcag gaacaaatac taaactacaa 56640
gttagattag atttatcaac tgaaaatagc tttttacgtc ctcgtgttcg tagacttatg 56700
gttactacta gggatgaata aactagaggg gttgattgac ccctctttat ttaataagga 56760
gagatttata tgcctagaga agttagagac ccttattctc aagctaagct atttatacct 56820
acagttgaag aaaaatcaat taaggaatta gaaagaacat ataaggaaaa aattaatgaa 56880
gttgatagac ttcttaatga attaaagaaa gagagaggag aaaaatagat ggcatttaat 56940
tacacgcctc ttactgaaac acaaaagtta aaagatatgt acccgaaggt aaatgatatt 57000
ggtaactttt taaaaacaga ggttaacctt agtgatgtaa aacagatatc acagcctgat 57060
tttaataata ttttatcatc tatacctgat agcggtaact attatgtaac taattcaaga 57120
aatgctcctg caggagaagc aacagcagga tttgtaagat tagataaaag aaatgtaaat 57180
tattacaaaa tatattattc accttatagc agtaataaaa tgtatattaa gacttatgct 57240
aatggaacag tatatgattg gattagtttt aaattagatg aaggtagttt atataatgag 57300
ggtaatacta ttaacgtcaa agaacttact gaatctacaa cacaatatgc aacactagtt 57360
aatcctccta aagagaactt aaacactgga tgggttaatt ataaagaaag taagaatggt 57420
gtttcttctt tagtagaatt taatccagtt aactctactt caacttttaa aatgataaga 57480
aaactaccag tacaagagca aaaacctaac ttacttagag atagtttatt tgtttatcct 57540
gaaacaagct cttctaacat taaaacggat aattgggcta cacctccatt ttggggatat 57600
acagctaata gtggtcgttc aggagttaga tttagaggag aaaacactat acagattgat 57660
gatggtaata gcacataccc tacagcaatg actaatagat ttaaaatggg taatgagctt 57720
tctgtagggg atactataac tgtatcagta tatgctaaaa ttaatgaccc tgctttactt 57780
aaagataact tagtttattt tgaactggca ggatatgata ctgtagatag aacagataat 57840
ccttatacag gtggtcgaag agaaataaca gcaagtgaaa taactactga gtggaaaaag 57900
tattcattta catttacaat acctgaaaat acgattggtg cgtcaggtgt taaagttaat 57960
tatgtgtcac tacttttacg aatgaattgt tcttctagta aaggaaatgg tgcagtagta 58020
tattatgctt tacctaaatt agagaaatca tctaaagtaa ctccgtttat tacacatgta 58080
aacgatgttc gtaaatatga tgagatttgg tctaattggc aggaagttat tagtaaagat 58140
gaattaaagg gtcattcccc tgtagacatt gagtataatg attacttcaa gtaccaatgg 58200
tggaagtcag aagttaatga gaaaaactta aaagatttag ctatgactgt acctcaaggc 58260
tatcatactt tctattgtca aggttctatt gaagggacac ctaaaggacg ctctattaga 58320
ggaactatac aagtggatta tgataaaggt gacccttata gagctaataa gtttgttaag 58380
ttattattta cagatacaga aggtatacca tatacattat attatggtgg ttacaaccaa 58440
ggttggaagc ctttaaaaca gcaaagaaca tctacaatac tttgggaagg cactttggat 58500
tacggttcaa aagatactat tcctttaaat gattcatgga ctaactatga cttattagaa 58560
gttgtatatc tgactaaatc agcgggacat tataaaacaa tgtttttaga tttaagaata 58620
cctacgactc cgtatttata tataagagat tttaatttat ctaacaactc tacaggttca 58680
ggagtagact tctttgaagg atatttaact ttccctacaa atacttcagc aacaccaact 58740
atggttaaaa aggttacttt aaatgggtct actaatacaa catctgtaac agattttaat 58800
gcacaaggaa taataactat atatagaata gcaggaatta acacacttta ggaggttaga 58860
taaaatggct agacaatttg atattggtag agacgaaata gtattacacc ttagagatgg 58920
taaatatatt acaggattta caacggcagg agcttatgat gaagactttg gtcaggttaa 58980
ggttaataga gaaattttac ctgcttactt ctttgataac tttgctcttg atagatatct 59040
atactataaa aaaccggaag aggttataga gaataaaaac tatgtacctc ctcaaattaa 59100
taatagtgat gaggaatctc aacaaaatac tgtacctaaa gaacaatatg atagtttaaa 59160
agaagagcta gaacttatga gacagcaaca agaagctatg atgaaaatgc ttcaacaact 59220
cttaggtcaa aaggggtaat aataaatggc attaaatttt actacaataa cggaaaacaa 59280
tgttattaga gacctgacta ttcaggtcaa taacattgga gaagaattaa caaaagaaag 59340
aaatatattt gacattacgg atgatttagt ttataatttt aataaatcac aaaaagttaa 59400
attaacagat gataagggtt tatctaaatc ttatgggaat ataactgtaa ttagggatat 59460
aaaagaacca ggttattatt atataaatgc aagaacatta gctacattat tagataaacc 59520
tgatatggaa tcaatagatg ttttacttca tgtactacct ttagattcat ctactagagt 59580
agtacagcat atatatacat tgtctactaa taacaatcaa attaagacat tatataggtt 59640
tgtttcggga aactctagtt cagaatggca gtttataact ggattaccta gtaataaaaa 59700
tgctgttatt tcaggaacta atatcctgga tatatcttca ccaggtattt actttgttat 59760
gggaatgaca ggaggaatgc caaaaggtgt aagttcggga tttttagatt tgaatataga 59820
tgctaatgat aatagattag ctaagttaac tgattctgaa acaggtaaag aatacactag 59880
tattaaaaaa cctacaggtg tatacacaga gtggaaaaaa gaattagaac ctcaagatat 59940
gcaaaaatat ttattaagta gtatcaggga tgatggtagt gcatctttcc cattacttgt 60000
gtacactagt gataataaga cttttcaaca ggctgttata gaccatatag atagaacagg 60060
gcaaacaacc tttacctttt atgttcaagg tggtgtgaca ggttctccta tgtctaatag 60120
ctgtagagga ttattcatgt cagatacacc taatacatct agtttacatg gtgtttataa 60180
tgcagtaggt actgatggta gaaatgtaac aggctcagta gtaggtagta gttggacttt 60240
tcctaaaaca tcaccgtcac ataaagaatt atggacggga gcacaatcat tcttatccac 60300
aggtactact aagaatttag cagatgatat tagtaattat tcttatgtag aagtttatac 60360
taaacataag acatcagaga aaactaaagg taatgatgat acaggtacaa tttgtcataa 60420
attttatcta gacggtagtg gtacctacgt ttgctcaggt acatttgtat caggagatag 60480
aaccgataca aaaccaccaa ttacagaatt ttatagagta ggtgtatcct ttaaaggttc 60540
aacatggact cttgtagata gcgcagtgca aaatagtaaa actcaatatg ttacaagaat 60600
tataggtatt aatatgccat agactaggaa acttatccta gtcttttttt cttgacttga 60660
gaaggattat gtgatatact ataactcgtg taaggatata aggagattaa aatgagatta 60720
agaattaaga acttatatac ctatgtagaa tttgaggagg atgataaata cttaaaagat 60780
atatttttaa agagagttca tacgactata ggagcaaggc aggagggatt ccagtatagc 60840
cctgcttaca aaagaggtag ttgggatggg tatgtagact tttatgttta tgaagaagat 60900
aaatttccca ctggactttt atttaagatt gagttattat taggggagtt acaatcaaga 60960
tataacttcc agtttgaaac aattgatgag cgtgatgaaa gtttcttagc tgaggaagat 61020
attgatgatg aaataacatt acttgataat aatattggtc aaattacttt aagagattac 61080
caatatgaag cagtatataa tagcttaaca ttttacaatg gtattgctca cttagccact 61140
aacggaggta aaacggaagt tgctagtggt attatagacc aactattacc tcagttagaa 61200
aaaggagaaa gagtagcatt tttcacaggc tctacagaga tattccatca atctgcagat 61260
agattaagag aacgtttaaa tattcctata ggtaaagttg gtgcaggtaa gtttgatgtt 61320
aagcaggtta cagttgtaat gatacctaca ttgaatgcaa accttaaaga ccctacacaa 61380
ggggttaagg ttacacctaa acaaaatatt agtaaaaaaa ttgcacaaga gatattacct 61440
aaatttgaag gtggtacaaa ccaaaagaaa ttattaaaag tattacttga taatacaaca 61500
cctaaaacaa aagtagaaca aaatgtatta aatgttttag aattaattta ccaaaatagt 61560
aaaactgatg cagaggtctt gttaaactta aaaaaacata atgcacattt ccaaaaagtt 61620
gttagagaaa agaatgaaaa gaaatatgat aaatatcaag atatgagaga ctttttagat 61680
tcagtgactg ttatgatagt tgatgaagca catcactcta aatcagattc gtggtataat 61740
aatctaatga catgtgaaaa agctttgtat aggattgcat taacgggttc tatagataaa 61800
aaagatgaat tactatggat gagattgcag gctctatttg gtaatgttat tgcacgaact 61860
actaataagt ttttaattga tgaaggtcat tctgctagac caacaataaa tattatacct 61920
gtagctaatc ctaatgacat agatagaatt gatgattaca gggaagctta tgataaaggt 61980
ataacaaata atgattttag aaataaactt attgcaaaac taacagaaaa gtggtataat 62040
caagataaag ggacattgat tattgtaaac ttcatcgaac atggagatac aatatcagaa 62100
atgttaaatg atttagatgt agagcactac ttcttacatg gagaaataga ctctgaaact 62160
cgtagagaaa aattaaatga tatgagaagt ggtaagctta aagtaatgat agctacatca 62220
cttattgatg agggtgtaga tatatccggt attaatgcgc taatattagg tgcaggaggt 62280
aaatcgttaa gacaaacatt acaacgtatt ggtcgtgcgt tacgtaagaa gaaagacgat 62340
aatacaacac aaatatttga ttttaatgat atgacaaata gatttttata tactcatgct 62400
aatgagcgta ggaaaattta tgaagaggaa gattttgaaa taaaagactt aggaaaatag 62460
gagggtaaga gatggcaaca agaacacaac gaaagttata ccaatatcta gaagaaaatg 62520
ctacagaaaa taaatttcat atttctacta agaaagagtt agcagattct ctaggcgttt 62580
ccatctctgc tttatccaat aaccttaaaa agttagaaga agaaaataaa gttgttactg 62640
tttctaaaag aggaaaaaat ggtggagtaa taataacttt agttagggaa tatgacacag 62700
aagaattgaa agaatttaat aattctacag ataatatcat tacttctgat ttacagtatg 62760
ctaaagcatt aagagaaaag cactttcctt cttatagata cgagaggaaa gaacagcgta 62820
gacgtactaa gttagaaatg gcacagtata atgctattaa agatgaaaag agaagaatta 62880
tagcagatat gaactttcat tcagaaggtc ttccttatcc ttctaaagat atatttaata 62940
tgtcttatga cccggaagga ttttataaag catacattct atgtaagtta tatgaccaat 63000
atgctatttc tcatatggat gctaaacata caagccatct taaagcaatg agtaaggcaa 63060
caactaaaga tgaatatgat taccatcaac atatgtctga atactataga aataaaatga 63120
ttcaaaattt acctagaaat agtgttagtg ataatttctt cggtagtaaa atgtttaata 63180
ctttctataa tttttattta aaaataaaag ataaaaatat taatgtattt aaatatatgc 63240
aaaacgtatt taagaatgta acattttatt atgagaatgg tatgcaacct aatccaatac 63300
cttctcctaa cttctttagt tcagataagt attttaaaaa ctataataat tatattaaag 63360
gaataaaaaa aggtgttaat agtacaaata gacacttagg ggatacagat agtattatta 63420
attcatcaga ttatgttaag aaccctgctg tattacattt acatcaatta tatactacag 63480
gattaaattc tactttacat gatattgata ctatgtttga gcaagcctta gaccttgaga 63540
atgcttctta tggactattt ggagatatga aacatattat tttactacaa tataattcta 63600
tgattgaaga agaaattaag aacttaccta cagaagagaa aagtattatt aataaatatg 63660
taaaacaatg cataattaat gattactccc caacaagcat atcaccatct gcaagattat 63720
caatgtttac tatgcagaaa gagcatatag tttataataa acagttaaac agaggaatca 63780
agagagaaga tttattacca ttaagtctag gaggtatagt gaataaagat tcactaagtg 63840
gtatggatat acaaaactta gagcagaatg gtaatgagta cctatatatg agacaacata 63900
cttcaactta ttatatacta agaatgtttg gtgattatct aggatatgaa gtaaacttaa 63960
gagaagtaaa atatattgta gagaaatata atttaattga taaaatacca ttgacaaaag 64020
agggtatgtt ggattataat aaacttatac atttagtaga ggaagaggtt aataactatg 64080
agtaagaaga taaaggagct tatccttcat aaatcaatga aggatataca ttttgcaaga 64140
gaagtactag ataacttacc taagaaccta ttttcagcag aatctgaaga tatgggttac 64200
ttatttacag ctataaaaag aacagcacat atttccgata agatgtctaa tgaagcatta 64260
gcaattaaag tagaacagct tatgggaaat aataaggaag atgaagaaaa agtaaccaag 64320
acattgactt acttagaaga tttatataaa gtagatgtta atgaaaaaga tgaatctgtt 64380
aattatgaaa tagagaaata tattaaaaca gaaatgtcta aggaagtatt agttaagttt 64440
attgcagaaa ataaacaaga agactcagac aatttacatg aacttgtaga taaattaaaa 64500
caaatagaag taagtgatat ttcaggaggt aacggagaat ttattgattt cttcgaagac 64560
actgaaaaga aacaagaatt attaagtaat ttagctacaa ataaattctc tacaggattt 64620
aactctattg ataatcatat tgaaggtggt atagcaagag gagaggttgg attaattata 64680
gctccaactg gtagaggtaa atcattaatg gcttctaact tagctaaaaa ttatgtgaag 64740
agtggattaa gtgttttata tattgcatta gaggaaaaaa tggatagaat ggtattacgt 64800
gcagagcaac aaatggcagg agcagaaaaa agccaaattg taaaccaaga catgtcttta 64860
aacagtaaag tttatgatgc aatacaaaac cattatcaga agaatagaaa gttactaggt 64920
gacttttata tttctaaaca tatgccagga gaagttacac caaaccaact agagcaaatt 64980
attgttaata caacaatcaa gaaagataag catattgatg ttgttattat tgactaccct 65040
cacttgatga gaaatccata tgctaaatat cactcagaat cagatgcagg aggaaaactg 65100
tttgaagata ttcgtagatt atcacagcaa tatgggtttg tatgttggac tttagctcag 65160
accaaccgtg gagcttatgg ttcagatgtt attacaagtg agcatgtaga aggttctcgt 65220
aagattgtca atgctgttga ggtttctcta gcagtaaacc aaaaagatga agaattcaag 65280
agtggtttcc taagattata cttagataaa attcgtaaca gttctaatac aggggaacga 65340
tttgttaatc ttaaggtaga accaactaag atgattgtaa gagatgaaac accggaagaa 65400
aaacaagaac atatacagct attatctgac aatggaaaag aagatacaag taaattccaa 65460
aataaagata ataaaataga agctataaat aacacattcg gaggattacc gggagtttaa 65520
atttttacta tataccactt gacattttat atgttaggtg gtataattat tttataaaga 65580
ataaaaggag agattaatat gaaaattaaa caaatattac ctagtaataa tccaaacaaa 65640
tatcaccttt tgattgagag caagctaata cctagttact actcaacaag agatgatgtt 65700
tataatgatt attatgattt aaatctatat ggtatgtttg atgatagtga aaatttatta 65760
tgttcatgtg caatagaaaa gtataatgaa ttagtattta tgaaaaggtt tgttatggtt 65820
ggggaacatg gtaatggata ttttaaacag atggtttctc ttataataaa agaagaacct 65880
catatatgtt taactataaa taaagataat attaaagtag ctgatatctt aaatgaacta 65940
ggatttatta atgcaggaga agtaattgat agaacaggaa agtatactta tgaattatac 66000
caaggaggaa gagcttaatg aagtttgtat tttttacaga tagtcatttt catttattta 66060
caaactatgc aaaacctgat gatgaatttg taaatgatag atttaaagag caaatagaag 66120
cattacagaa agtttttgat attgctagga aagaaaaggc taatgttatt ttcggaggag 66180
atttattcca caaacgtaat tcagtagata ctagagtata taacaaagta tttagtacat 66240
ttgctaaaaa taaagatgtc cctgtattat tacttcgagg taatcatgat gctacaacta 66300
attcattata taccgattca agtatagata catttgagta tttatctaat gtaagtgtaa 66360
taaagtcatt aaatacaatt ttaaaagata atgttaatat tgtatttaca gcttatggag 66420
atgaaacaga agaaataaaa acctacatta acagtaacta tgataaagat atggttaata 66480
tactagtagg tcatctaggt gtagaagggt cattaactgg taaaggttcc catagattag 66540
aaggagcctt tggatatcag gacttattac ctgataaata tgattttatt ttactaggtc 66600
attatcatcg tagacaatat ttccaaaacc caaaccattt ttatgggggt tcattaatgc 66660
aacaatcatt ttctgatgaa caagaagcta acggtgttca cctaatagat acagaaaaga 66720
tgaccacaga atttattcca attcatacac gtagatttat tactatccag ggagaagata 66780
tacctgaaaa ctttgaacaa ttaatagagg aagataattt tattagagtt attggtacct 66840
caaaccatgc taaagtttta gagatggatg atagtatgaa ggataaaaac gttgaagttc 66900
aaattaaaaa agaatatact gtagagaaac gtatagatag tgatgtatct gatgaccctc 66960
taacaattgc tagcacttat gctaagcaat actcacctga atcagaacaa gaaatacttg 67020
aatgtttgaa ggaggtttta tagtgagaaa atataaagaa tatctaaaca agtcagatga 67080
agaaaattta gcagaagatt gggaacggat aaaagaagat ttatggaaag tgtttaaaga 67140
tatgaaacct aaaattaata cattagacat cagtaatgta gtaagtaaag acttagataa 67200
aagtaagcct attttacaat ttcaagattc agacagagta atagagaaca tttgtaatgt 67260
tgaaggttta gaagatggtt tatctaaaat gaaaaagatt tttgacgata gtaattttga 67320
aaaacattac tataatagaa ttgtagaaca tgatgaatat tattggattg attatggttc 67380
tcatcattgt ttctttaggg ttacgaaagg agataagtaa tggtcgtatt taaacaagta 67440
gaagttaata attttttagc aattaaagag gctacactag agttagataa tagaggttta 67500
atacttattg aaggtgaaaa taaatccaat gagtcattcc attcaaatgg ttccggtaag 67560
tcaactttaa tatctgccat tacttatgct ttatatggta aaactgaaaa aggattaaaa 67620
gcagatgatg tagtaaataa tattgagaag aaaaatacat ctgttaaact taagtttgat 67680
attggagaag atagctattt aattgaacgt tatcgtaaag ataaagagaa taagaacaaa 67740
gtaaaattat ttgttaatga taaagaaatt acaggctcaa caaatgatgt tactgataaa 67800
cagatacagg atttatttgg tattgagttt aatacgtatg ttaatgctat catgtatggt 67860
caaggagata ttcctatgtt ctctcaagca acagataaag ggaaaaaaga aattcttgaa 67920
tctattacca agacagacgt atataaacaa gcacaagatg tagcaaaaga gaaagttaaa 67980
gaagtagaag aacaacagaa taatctaaga cacgaaatag ataaactagg gtatcagtta 68040
tctacaaaag atgaatactt tcaaaaggaa attgaacagt ataatcaata taaagaacaa 68100
ttggctcaaa tagaaaatag taataaggaa aaagataaat taagggagca agaggagaag 68160
caaatagaag ctcaaataga gcaattaact tcacagatac caacaatacc tgaagatgaa 68220
tttaagcact cagaggagta taataaagct tctcaaagcc tagatttact ttctaataaa 68280
ttaactgaac taaatcaagt atatgcagag tataatacta aagagcaggt actaaaatct 68340
gaaatagcta cattaagtaa tagcttaaat caattagata caaatgacca ttgtccggtt 68400
tgtggttctc ctatagataa ttctcataaa ttaaaagagc aggaaaatat taataatcag 68460
attgagaata agaaacaaga gattactagt gtactagaaa ttaaagatac gtataaagaa 68520
gctattgata aagtaaataa taaatcacaa gaaattaaag acaaaatgtc tcaagaagac 68580
caacaagaac gagagcacaa cactaggatt aataatatca ttcaagaggc ttccaagatt 68640
aaatcagata ttagttcatt agagaataat aaaacttatt taaaagtgaa atatcaacat 68700
caatctgttc aaggattaga aagagaagaa ccaagtaaaa agaaacatga agaagataaa 68760
aaagaattac aagaatctat tgacaaacat gaagagaatg tagtacaatt agaaactaag 68820
aaaggtaagt atcaacaagc tgtagacgct tttagtaata aaggtatacg ttcagtagtg 68880
ttagacttta ttacaccctt cttaaatgag aaagccaatg aatatcttca aactttatca 68940
ggttcagata ttgaaataga gtttcaaact caagtgaaga atgctaaagg agaactaaaa 69000
gataagtttg atgttattgt taaaaatagt aaaggtggag gctcatataa atcaaactca 69060
gcaggagaac aaaaacgtat tgacttagca attagttttg caatccagga tttaattatg 69120
agtaaggatg agatatctac aaatattgca ctttatgatg aatgttttga tgggttagac 69180
actatagggt gtgaaaatgt aattaagtta ttaaaggata gacttaatac agtaggaact 69240
atatttgtaa ttacccataa tacagaactt aaaccactgt ttgagcaaac aattaaaata 69300
gtaaaagaaa atggagtatc aaaactggag gaaaaataat gaaattaaag attttagata 69360
gagataatgc aacacttaat gtgtttcatc gtaataagga gcacaaaacg atagataatg 69420
tacctactgc taacttagtt gattggtatc ctttaagtaa tgcttatgaa tataagttaa 69480
gtagaaatgg agagtattta gaattaaaaa ggctacgttc taccttacct tcttcttatg 69540
gcttagagga taataaccaa gatattatta gagataataa ccatagatgt aaaataggat 69600
attggtataa tcctgcagta cgtaaagata atttaaagat tattgagaaa gctaaacaat 69660
atggtttacc ggttataaca gaagaatatg atgctaatat tgtagaacaa gggtttagag 69720
acattggagt tatattccaa agtcttaaaa ctattgttgt tactagatac ctagaaggta 69780
aaacagaaga agaattgaga atttttaaca tgaaatcgga agagtcacaa ttaaatgaag 69840
cacttaaaga gagtgatttt tcggtagatt taacttatag tgacctaggg cagatttata 69900
atatgttact attgatgaaa aaaattagta aatagtaagg aaggatatta tgaggtttga 69960
agacttttta acccaagaat taggagaacc aaaagaaaat actataggtg aactaagata 70020
ctgttgtccg ttttgcggag aaaaaagtta taagttctat gttaagcaag ctttagactc 70080
tagtaatggt cagtatcact gtaaaaaatg tgatgaatca ggtaatccta ttacatttat 70140
gaagacttat tataacatta caggtaaaca agcttttgat ttattagagt ctaagaatat 70200
agatatagag agagcccctt tacttacaac taataataag gatttaacag aatcagagaa 70260
acttatatta atgcttagag gcgtacacca agataaagga aacactaatc ttaaacctcc 70320
tagattacct gagggatata agttattaaa agataactta aataataaag agattatacc 70380
ttttttaaaa tacttaaaag gcagaggtat aactttagaa caaataatta ataataatat 70440
aggttatgtt attaatgggt gcttctataa agttgatgga gaatcaaaag tctcattaag 70500
gaatagcatt atatttttta cgtatgataa tgatggaaac taccagtact ggaatacacg 70560
aagtatagag aagaaccctt atattaaatc tatcaatgcc cctgctaaac aagatgaagt 70620
aggaagaaaa gatgtcatat ttaatttaaa tatagcaaga aagaaaaaat tcttagttat 70680
aaccgagggt gtctttgatg ctttaacctt tcatgaatat ggagtagcaa cactaggtaa 70740
acaagtaaca gaaaatcaaa taaaaaaaat aattgattat gttagcatag atacatcaat 70800
atatattatg ttagatactg atgcgttaga taataatata gatttagctt ataagctaaa 70860
aacgcacttt aacaaagttt attttgtacc gcatggtgat gaagatgcaa atgatatggg 70920
aacaaggaaa gcttttgagc tattaaaaca gaaccgagta ctagtaacac ctgaaagtat 70980
acagagttac aaaatacaac aaaaacttaa actttaggct tgaccttaga gaagttttat 71040
gttatactaa taattaagta attaataaag gagaaaaaat aatgtcaaat aataaaaaag 71100
atattttaga atttgtagat gaatacatta cagctttaag agttggtaat gagcaacgac 71160
aacatcaatt agaagaaatg ggtaaagaag aaacagcaac attaacagat gtagctaaag 71220
ctattactaa ccttatgtta ggtgttaatg agcaaatgac agacttggaa tacaacaatg 71280
agttaaattt aaatatttta attgacgctt tatataaagc agaacttatt aatgaagatg 71340
tactagatta catccaagaa tcaattgata aatcacaaga agaacctaaa aatgaagaag 71400
aaaaaggaga acaagaataa tggaaaaaaa tattagcaca cacacaaaag gtattagtca 71460
agcagacatg gagaaatgga ttgaagctgt agtccaagga actgttgatg gtaaacaagt 71520
tgatgaaaaa acagctaaac aactagatag aattggttca cgcagtgttt ctttagaaga 71580
agcaactcgt attgctaaag tcattaatgc tgttacagtt caagagatgt caggagattt 71640
taatgacgca tttaacgcaa ttgacttaat gatgattgtt atggaagatg agttaggagt 71700
aactcaagaa caagttggaa aagctaaaga taagttaaat gagaaacgag aagcttattt 71760
aaaagagaag caagaagaat tacgtcaaaa acaacaagaa gagacacaaa aagaaactga 71820
atctgacagc aatgaaaaag taattcagtt gaagaaaaat gacgaacagt aagaaaaaag 71880
gagatacatt cgaacgtaaa atagctaaag aattaactgc ttggtgggga taccaattta 71940
ataggtctcc tcaatcaggt ggtgcctctt ggggtaaaga taataatgct gtcggagaca 72000
tagtagtacc tcaggaagct aattttcctt tagtagtaga atgtaaacat agagaagaat 72060
ggactataga taacgttctt ttaaacaata gagaaccaca tacatggtgg gaacaagtaa 72120
ttaatgatag tagcaaggtg aataagacac cttgcttaat atttactaga aacagagctc 72180
agagttacgt tgctttacct tatgatgaga aagtatatga ggacttaaga aataatgaat 72240
atcctgttat gagaacagat tttattattg ataatattag aaaagataaa tttttttatg 72300
atgtccttat aactaccatg aatgggttga cctcatttac accttcttat attatatctt 72360
gctacgacaa aaaagatata aaaccataca agaaggttga gtctaattta tctgaggtaa 72420
gtaagcatga agatgaattg attaatgacc ttcttaatga tatataagga agggtaagat 72480
aggtatgaca agtaaagaaa gaccattaat tgtatatttt tcaggtacag ggcagacaga 72540
aagactagta aacaaaatta atattaatag ctcatttgaa acgtttaggg ttaagagtgg 72600
aaaagagaaa ataaataaac cttttatact aataacaccg acttatatga agggtgcaat 72660
acctaaacaa atagaaagat tcctagaaat taatgggagc cctaaggaag tcattggtac 72720
aggaaataaa caatggggct ctaatttctg tggagcaagt aaaaagattt cagagatgtt 72780
taagattcct ttaattgcta aagtagagca atcaggacac tttaacgaga tacaaccaat 72840
attagaacac tttagtaata aatataaagt agcgtaaagg atgagagata tatggcaaca 72900
tatggaaaat ggattgagtt aaataatgaa ataactcaat tagatgacaa tggaaaaaat 72960
aaactctata aagaccaaga agctttagat gagtatttaa aatatattga agataataca 73020
agaaagttta ataatgaagt agaaagaatt agagtattga caaaagaagg aacatatgat 73080
aaaatatttg ataaagttcc tgatactatt attgatgaaa tgactaagct agcttacagt 73140
tttaatttta aatttcctag ttttatggca gggcaaaagt tttatgagtc ttacgcatca 73200
aaacagtatg acgagaataa aaaacctatt tttgttgaag actatgagca acataacgtt 73260
cgagtagctt tatatttatt tcaaaatgat tatgtaaagg ctagagagtt attagtacaa 73320
cttatggagc aaacatttca accatctaca cctacgtata ataactcagg gcaagctaat 73380
agaggtgaac taagttcatg ttatctattt gtagtagatg attcaattga gtccttaaat 73440
tttgttgagg atagtgtagc taatgctagt tctaatggtg gcggagttgc aattgattta 73500
actagaatta gaccgaaagg tgctccagta cgtaatagac ctaattcaag taaaggtgtt 73560
attgcttttg ctaaagctat tgaacataaa gtaagtatat atgaccaagg cggggttcga 73620
caaggtagtg gtgcagtcta ccttaatata ttccataatg atattttgga tttattaagt 73680
tctaagaaaa taaatgctag tgaatctgtt agacttgata aactatctat aggtgttaca 73740
atacctaata agtttatgga attagttaaa gaaggtaaac ctttctacac gtttgacact 73800
tacgatatta acaaagtata tggtaaatat ttagatgaat taaacattga tgagtggtac 73860
gaagaattat taaataatga taaaattggt aaagtaaaac atgatgctag agaagtcatg 73920
acagatattg ctaaaacaca attagaatca ggttaccctt atgtatttta tattgataat 73980
gctaatgaca atcaccctct taaaaatcta ggtaaagtta aaatgagtaa cttatgtaca 74040
gaaatttcac aattacaaga ggtatcagaa atttatccat attcctatag taatcagaat 74100
gttattaata gagatgttgt ttgtacatta ggttcactta acttagttaa tgtggttgaa 74160
aaaggtttat taaatgagtc cgtagatatt ggtacaagag cactaacaaa agttactgat 74220
attatggatt taccatatct acctagtgtt caaaaagcaa atgatgacat tagagctatc 74280
ggtttaggtt caatgaattt acatggactt ttagctaaga atatgattag ttatggttct 74340
agggaagctc tagacctagt aaacagttta tatagtgcta ttaacttcca gtctattaag 74400
acatctatgt taatggctaa agaaacagga aaaccattta aagggtttga aaagtctgat 74460
tatgctacag gtgaatactt tgtaagatat attagagagt ctaaccaacc taaaacagat 74520
aaagctaaga aagtcctaag caaggtctat attccaacac aagatgattg ggatgaatta 74580
gctaaagcag ttaaagtata tggactgtat aatgggtata gaaaagcaga agcacctact 74640
caatctatat catatgtaca gaatgctaca agctcaatta tgcctgtacc tagtgctata 74700
gagaacagac aatatggaga catggaaaca tactatccaa tgccttattt aagtcctata 74760
actcagtttt tctatgaagg agaaacagct tataagattg ataataaacg tattattaat 74820
acaagtgcag tagtgcaaaa acatacagac caagcagtat ctactatact ttatgtagaa 74880
tcagaaatac cgactaataa gttagtatca ttatattact atgcttggga acaaggatta 74940
aaatcattat attatacacg ttcacgtaaa ctttctgtta ttgaatgtga aacatgttcg 75000
gtttagaaag gaaatagata tggatattac acaaaaagta aaacaacata ataaaaatgc 75060
agtattaaag gcaacaaatt ggaatattga agatgacggg atgtctgata tttattggga 75120
gcaaggaatc tcccaatttt ggactcctga agagtttgat gtatcaagag atttaagttc 75180
ttggaacagt ttaactgaga gtgaaaagaa cacttataag aaagtccttg cagggctcac 75240
agggctcgat acgaagcaag gaggggaagg tatgaactta gtatcttatc atgaaccaag 75300
acccaaatac caagctgtat ttgcgtttat gggtggtatg gaagagatac atgctaaatc 75360
ttatagtcat atctttacaa cactattaag taataaagaa acaagttatt tactagatac 75420
ttgggttgaa gaaaatgact ttttaaaagt aaaagctcag tttattggat attattatga 75480
ccaattatta aaacctaatc ctactgtatt tgatagatat atggctaaag tagctagtgc 75540
ctttttagaa agtgcattat tttactcagg attttattac cctttacttc ttgcaggaag 75600
agggcagatg acacaatcag gagctattat ttataaaatt acccaagatg aagcttatca 75660
cggttcagca gtaggattaa cagctcaata tgattacaat cttttaacag aagaagaaaa 75720
aaaattagca gatagagaaa cttatgaatt attaaatatt ctttatacta atgaagtagc 75780
gtatacacat agtctatatg acccgctaga gttaagtgaa gatgtaatta actacgttca 75840
gtataacttt aatagagctc ttcaaaacct tggaagagaa gactatttta accctgaacc 75900
ttataaccct attgtagaaa atcaaactaa tgtagacaga ttaagaaatg ttgatttctt 75960
tagcggtaaa gcagactacg aaaaatctac aaacattaaa gatattaaag atgaagattt 76020
ctcattctta gatagtaaag agtatagtac tgctaaggaa ttcctataaa aaggagaaaa 76080
gatattatgg atagaaaaga agcaatggat ttattaagta aaacagaaat attatttaaa 76140
aaacatgatg agttttcatg tgtgagtgat atcaatgacc ctatgaagtt atttagtaac 76200
tctaaagatg ccaaagctga tgatacgtct aagtcttttc agttagagtt tatgcatgat 76260
atgactatgt atactttatc ttatggctca ggacagttaa aactcattga tttatcagaa 76320
ggttatgaag cacaaaaagc tacagcagtt aactcatttc ccgaaattat taaaacatta 76380
gaaaaggatg actcagaaga tggaaaaaat gaataattta gtagatttaa atacagcaat 76440
tagacaaaag aaagatgtta ttgtcatgat tacacaagat aattgtggta agtgtgaaat 76500
cttaaaaagt gtaatcccta tgttccagga ttcaggggat attaagaaac ctattttaac 76560
acttaattta gatgcagaag atgtagatag agaaaaggct gttaagttat ttgatatcat 76620
gagtacacca gtattaattg ggtataaaga tggtcagtta gttaaaaaat atgaagacca 76680
agttacacca atgcaattac aagaattaga gtcactttaa tttggaattt cctactatct 76740
gtgctatact ataatagtac aaggtagtag gattttttta atgaaaggaa gatgacatat 76800
cgcaaagaat aaaacattaa cgatatataa tagtgataga tattttaata tacacacaaa 76860
agataaagat aaaattaatg aggctattaa agtcacacac ggtaatgaag aagaaattga 76920
aaagaatatg gatgaactaa tatctaaatc tagacgatat attatgagag atgaaaatca 76980
ttatatgtta tttaatgaga aatacaataa tgataggctc atagagaaag tatgtaaaca 77040
tggtggtaaa gttacatact atactgattc agtattacct tattatgttt taaaagactt 77100
atctagtcac cctgattcag aagttgttta tcgtatgcgt aacggcttta ctgcaaaaga 77160
agtagataat atagctttat catttatggg aacaaaagtt attattgata tttctgtggt 77220
atttccttat gtaaatcctt atgatattat tagaagttta catgatatta aaacaaatgt 77280
agatgaagtt catttatcat ttcctcgtat attagaagta gatgaaaaac aagaaaaatt 77340
ttatttcttt gatggtgaag cttatgattt aaaacctgaa tataaagttg attttgcaga 77400
taaaattaga gtgtccctat cagtatggaa aatgtatatc tatatcttaa caagtagtcg 77460
tgattttgaa gatgtagaca atgtaattac gaaactaaaa caacaacgaa agattaagat 77520
ataaggtgat tatatgagta cagcaaatag aagagatata gcaaggaaga tatcagagaa 77580
cacaggttat tatatacaag atgtagaaga gatactaagt gcagagacag atgctatttc 77640
tgacttacta gaagaagggt atactaaagt aaagaatcat aaatttatgc aaatagaagt 77700
tattgaaaga aaaggtaaaa aagcttggga tgggctgaat aaagaatatt tccatttacc 77760
taatagaaaa gctataaaat ttaaaccact taaagaatta gaagaggtta ttgatagact 77820
taatgaagaa gagaaataat tctcttcttt ttttattgac aagatttaaa atatatggta 77880
tagtattatt aagttaaaaa aggagaggaa ttaaatgaaa gtattaatct tatttgacca 77940
cattagagaa gaacattttt ctgtaagtaa agatgggagt gtgaaatcta atgtattaaa 78000
tacacctaat ggaaaaacac ttaagaaatt acttgagaag tgttctaact taaagagaga 78060
taaaacaaac agagactatg atattgattt tctctataac gcagtaccta cacctattag 78120
aaatgattat ggtaaaatta ttaaatacca agatgttaaa caagcagaag taaaaccata 78180
ttatgaaaga atgaataaca ttattattga taactcctat gatatgataa ttcctgttgg 78240
taaactaggt gttaaatact tattaaatgt tacagctata ggtaaagtaa gaggagtacc 78300
aagtaaagta acaattgaaa atgaaatatc ttctcatgat gtatgggtac tacctacgta 78360
tagtattgaa tatacgaatg taaataaaaa tagtgaacgt catgttgtat cagatttaca 78420
aacagtagga aaatttgtag aacaaggtga agaagcattt aaacctaaag aagtatctta 78480
cgaattagta gataacattg aaagagtaag ggaaatattt aataaggaag taaagaatga 78540
taattatgat ggtgtagata tcaccgcatg ggacttagag actaactcat taaagcctga 78600
taaggaagga agtaaacctt tagtattatc actatcatgg agaaatggtc aaggtgtgac 78660
tataccttta tacaaatcgg actttaattg ggaaaatggt caagaagata ttgatgaagt 78720
actagaatta cttaagaatt ggttagctag taaagaagat attaaggtgg cacataatgg 78780
taaatatgat attaaatttt taatgagtac tgagaacttt aaagattttg agaacattca 78840
agatactaaa gtaggttggt atttagctgt cacacaagaa gttaaagaat ctttgagatt 78900
atctgactta gcttacgagg taacagatgt cggaggttat gataaaccac tagaagattt 78960
taaattatgg tttgttacta agttattaag atttttctct gataaaatta aagaaataca 79020
gaaagaaaat aaaaaaattg ctaagaaaga gtatgatgtt aaagctcctg aatacaaaga 79080
gtggttagag actaaattaa atgaaacaat agtagaatta gatgatactg agaagaaatt 79140
tagagttagt gaattagaga aaaaatacat tcagttaggt ctttcacctg aaattgtaaa 79200
catgaattta gttatgaaca acgatgaatt tattagtatt gcagagcaat cacctgaata 79260
tatgggatta tctgattacg ctaaatctta cacactgaat actgcaattg atttaattaa 79320
caagtataga gatgtaaaag atgtaattaa tgatattgat ggaggtaact ttaactatga 79380
ttggttccct attgagttaa tgcacccgta cgcatcagga gacactgatg tatgtagaag 79440
aattcattgt gatgttgtta agaaacttaa agagcaagat agacctaagt caatgcattt 79500
attagaagtt aattacccaa gacttactaa atcattagct agaattgaat caaatggttt 79560
atactgtgat ttagattaca tgaaagaaaa tgatgagtca tacgaatctg agatggctaa 79620
gaaccacgct actatgagag aacattgggc tgttaaagaa tttgaagagt atcaatataa 79680
cctttaccaa atggcgttag aagagcatga gaaaaagcca aaagatagag acaaagagat 79740
tcatcagtat agagataagt ttaaagatgg taaatggatg ttttctccta gctcaggaga 79800
ccataaaggt agagtaattt atgatatttt aggaattcag ttaccttatg ataaagagta 79860
tgttaaagaa aaaccattta acgctaatgt taaagaagca gaccttactt ggcaggatta 79920
taaaacagat aagaaagcta ttggttatgc attagataac ttagaattaa aagatgatgt 79980
taaagaactt cttgaattac ttaaatatca tgctagtatg cagacaaaac gtaactcatt 80040
tactaagaaa ttacctaata tgattaataa acaaaaacga acattacatg gttctttttc 80100
tgagacaggt acagagacat caagattaag tagtagtaat cctaacttac aaaacttacc 80160
tgctcataca tcagatgtaa acaagtttga ttataaacat ccaattaaac gttcatttgt 80220
ttctagattt gaaaatggag tactactagg agccgactat agtgccctag agatgcgtat 80280
tattggatta tttactaaag accctgatat gctacaatca ttcttaaatg gtgaggatat 80340
tcataaggct acggcaagta ttgtttataa taaaccagta gaagaagtaa ctaaagaaga 80400
gagacaagca actaaagcag ttaactttgg gctagccttt ggagaatcac cattctcatt 80460
tgcaggtaaa aataatatgg aagtaagtga agcagaagaa atatttgaaa agtacttcca 80520
aacaaaacct agtgtaaaaa cttctattga caatgtacat gaatttgtgc aacaatatgg 80580
ttatgttgat acaatgcacg gtcatagaag atttatacgt tcagcacaat caacagataa 80640
aaagataaaa aatgaaggtc taagacaatc atttaatact attatccagg gttcaggtag 80700
tttcctaaca aatatgtctt taacttactt agatgatttt attcagtctc gtaacttgaa 80760
atcaaaagtt attgctacag tacacgatag tatcttaatt gattgccctc ctgaagaggc 80820
taagattatg gctaaagtga caattcatat tatggagaat ttaccgtttg atttcttaaa 80880
agcagaaatt gacgggaaag aagtacaata cccaatagaa gctgatatgg aaattggttt 80940
aaattataat gatatggttg aatacgatga agaagaaatt gatacattta attcttacca 81000
aggttatatt aagtacatga tgaatttaca gactttagaa gattataaag agtcaggtaa 81060
attaactgat gaacaatttg aaaaagctac taatgttgtt aaaagtgaaa aacatatcta 81120
tcaagaaatt taataaaagt attgacaata tgtttcactt atgttatact atataggtaa 81180
taagtataag gaggaaaaaa gagtgaatac aggagagatt agatttaatc gttctatgga 81240
tgaatggatt ataacaagta tgtaccagga tgaattaggt gaaatgaata ttgttgttac 81300
attctataat agagaagaaa ataaacatgg ctctaccgtt ttaccaacag agtcatctac 81360
tggagaagta acagaagaat tagcaagtct tgaagaagaa tatcctttag ctttaccgtt 81420
aagtagtatt tcagttaata tttaaaagga ggaactgata aatggagata cacattgatt 81480
ccctagattt tacaaatttt actattaaag atagaaatgg gaactcacaa gagtttgata 81540
ttacagatga attaaagatt acagaatata caatacaaga agattttatg caacaatcag 81600
ctaagtacgc tttttgggct tctatattag agaaggtcag agcatattct gaaatggagc 81660
aaagaaattt agaaacaatt ggtagtaagc ttaatctcac aattagacaa gagtatgaac 81720
aacaaggtaa aaagcctact aaagatatga ttgagtctag tgtgtatatt catgattcct 81780
atcaacaaca acttaaagtt gttgaggctt ggaattataa agttaaacaa cttcaatatg 81840
ttgtaaaagc ttttgaaaca agaagagata tgatgattca attaggtgca gagttacgac 81900
aaacaaataa aaatggtgga attactaacc cattttcaca ttaaaaaaga aagtaaagaa 81960
tataattgac aaatataaaa aactatgtta taataaataa gtaaattaat taaaaggaga 82020
aaagataatt atggatttca atcaatttat taacaatgag gcaagcaaat tagaaagtaa 82080
taacagttct tttaacaaca atgtagagag ctataaacct aaaaaccctg tattacgatt 82140
aggtaatatt aaagatgcaa atggaaataa agttactaaa gaaaatgctt ttgtacgagt 82200
attacctcct gcacaaggaa caaatgtttt ctttaaagaa tttagaacaa caggtattaa 82260
ctactctaag aaagatggtt ctcaaggatt cacaggacta acattacctg cagaaccagg 82320
ttcatctgtc cttgaccctt acattcagga ctggataaca aatggcgttc aatttagtag 82380
attccctaat aaacctggag tacgttatta cattcatgtt attgaatact ttaataataa 82440
cggacaaatt caacctaaaa cagatgagca aggaaatgta atgattcaac ctatggagtt 82500
atcaaacaca ggatataaag aattggtagc aaaccttaag gatactatgt taaaaccgtc 82560
acctaatgca cctcatagtt ttatttcagc aaatgaagca ttcttagtta atattgctaa 82620
agctaaaaaa ggtgaaatgt catggaaagt aagtgtttat cctaatgctc ctttaggtgc 82680
attacctcaa ggatgggaac aacaattatc agacttagaa caattagcaa aaccaacaga 82740
agaacaaaac cctaactttg ttaacttctt aatcaataac gttaataaca cagagttaag 82800
tcatgataac tttaaattta accgtgagtc taatgtatta ggtgaagaac cttcagaacc 82860
taaacaagct cctactcaac aagatattga tagtcagatg ccaagtaata ttggaggtca 82920
acctaaccaa ccacaacaag gtcaagtagg tcagtatact caacaaggtc aaaataatgg 82980
tcaaggacag cagttacaag gtaaccaaca gccaattagt aatactcaat ttggtcaagg 83040
aacaccttca ggacaacaac ctaataatac aggttcagtt gattgggata acttagctca 83100
acaacaatca caaccggatt caaatccttt taatgacttt gatgtaaaca gtgttgatga 83160
ttcacaagta ccttttgaga cacaacctca aaacacacaa caagcacctg aaccacaaca 83220
aactactcag gagcctccaa aacaaaaaca aacacaaagt attgacgatg tattaggtgg 83280
tctagactta gataacctat aagatataga gtgccttaga gcactctttt atttgagata 83340
taattactag gaggatatta aatggcaaga gcaaaaaaag gtaaagaagt agatttaaca 83400
gatttaaata caattgattt aggtaaagaa ttaggattaa cattattatc agatacaaat 83460
agagcagata ttaagaatgt tatacctaca atggtacctc agtatgacta tattttaggt 83520
ggaggtatac cgttaggtag attaacagag gtttatggtt taactggtag tggtaaatca 83580
acatttgcag ttcatttgtc taggattgca acacaattag gtgttattac catttggatt 83640
gatattgaag gaacagcaga caataatcgt atggaacaac ttggagtaga tgtttcaaaa 83700
ttattctcta ttcaatcagg agaaggtaga cttaaaaata cagtagaatt atctgtagag 83760
gctgtaggta aagaattaga gtactggatt gacacattta atgaaaagat acctggagta 83820
cctattgtgt ttatttggga ctcactagga gctacacgaa ctcagaaaga gattgacggc 83880
ggtattgatg agaaacaaat gggtcttaaa gcatcagcta ctcaaaaagt aattaatgca 83940
gtaacaccta aattaaatga tacaaataca gggttaattg ttattaatca agcacgtgac 84000
gatatgaatg caggtatgta tggtgaccct attaagtcta caggtggtag agcatttgaa 84060
catagtgcta gtttacgtat taaggttcat aaagcatcac aattaaaaca aaaaagtgaa 84120
ttaactggta aagatgaata tcatggtcat atcatgcgta ttgaaactaa gaaatctaaa 84180
ttatcgagac cgggacaaaa agcagaagca gacttactat ctgattatat ggtaggtaaa 84240
gaagatgacc ctatattatt aaatggtatt gacttagaac atactgtata taaagaagca 84300
gttgaaagag gtttaattac taaaggtgca tggagaaact atgttacatt gaatggtgaa 84360
gagattaaac ttagagatgc tgaatgggtt cctgtattaa aagataatag agagttatat 84420
ttagaattat tcagtagagt atatggagag catttcccta acggttactc accattgctt 84480
aataataaag taattgtaac tcaactagaa gagtatcaag ctcttgaaaa ttactataaa 84540
gaatgggcta cagataataa acaaaaggaa caagaggaag aactaaaagg agaatctcaa 84600
gaaaaggatt ctgaataata aatggataat ttaatagata aaaacatgaa tcaggtaaaa 84660
gaatctttgg ggaatgcaaa ttcctcagat gttcttcctt taccttataa agatatagca 84720
aagaaatttg aagaagtaaa agaaaaaggt gaatcaatta tcattgaaga aggtggattc 84780
ccttacacag attctacagt gatgtatata gaacatgtaa cagatagatg ggcaggagga 84840
tactccttaa ttagacatga aggtgaagag gttaaagtgc ctaaaactat ccatttctct 84900
gatatatatg ttaaggataa gtcacataaa gtaagaataa tcttcgaggg ggctaatcct 84960
tatgaagaaa gctaacaatg gtaatagata tgtaatagat atagatggta ttcctgttga 85020
ttttgaaaga gacttggata gtttacttaa caggtataaa aaccttagat ggtcgttgta 85080
tcatagatat gcaggtatat tatctaatga ctttgaaaga caagaattaa gagaatatat 85140
tgatgagcaa tttattaaac tagttaaaga atataatatt agaagtaaag tagattttcc 85200
agggtatatt aaagctaaat taactttgag agttcaaaat agttatgtta aaaagaatga 85260
aaagtataaa cgtactgaaa ttatcggtaa aaaagattat acggtagagt ccttaacaga 85320
agatttaaat gaggactttg aggataatca aattatgagt tatgtatttg atgatataga 85380
atttacagaa gttcaaagtg agctacttaa agaattactt attaatcctg aaagagaaga 85440
tgatgccttt atagtttctc aagtagcgga gaagtttgat atgaaaagaa aagaagtagc 85500
aagtgaattg acagaattaa gagattatgt tagatttaaa ataaatgcat atcatgagta 85560
ctacgcaaag aaagaattaa ataatcatag agttaatact gaaaatcata tttgggaaaa 85620
ctagttacag tgccttcctt gtgttatatt attatcgaga attcaataat aaagcatagg 85680
gaaggctttt ttctatgtct tatagaatgc tttaaaatag attactaaaa taaagattgg 85740
agattaagct tatggctaaa aagaatgtta atgatgtatt acaacaagaa tctgttacag 85800
tagcagataa gtatttacaa gttaaagtta accgtgacgg ttatactcgt acacacgaag 85860
gacaatatgc gtacaaagta gtttcagagg gagaagagtt attcttatac ccagtacaaa 85920
cagatggtaa aggtacatta aatgtaatga agaaatcacc tattgcttac actgatggag 85980
acaatatcca ttttgtagta aatacagtag tagaccctta taatcactca tttatccgta 86040
ctgaagatat taaaggatta gataaaggta aacaacttat tcaagctttc ttagctttcg 86100
ttgaagaccg tttcaaattt ggtgtttata acgtatttgt tgcaaataac aaagaagatg 86160
tattatctat cgtagaccct gcagataatg atgcagatga agttaaagat agtttagagc 86220
atgcacatga agatgtaatt gcggatttcc ctgctagccc tgctcgtaag gacgttaaag 86280
gcgtagattc aggagaaggt caaggagaca cttcagaacc atcagcacct aagaacgttc 86340
aagttactcc taaggaagac ggagcagacg tatcagcaga ataatataga taaaggatgg 86400
taaatttggc taagttaaat ttatacaaag gtaatgagtt actaaacagc gtagagaaaa 86460
cagaaggaaa atcaacaatc acgattgaga atttagatgc taacacagat taccctaaag 86520
gtacttttaa agtatcattc tcaaatgatt caggagaatc agagaaggtc gatgtccctc 86580
agtttaagac aaaagcaatt aaagttattt cagttaccct tgacgttgat agtttagacc 86640
ttacagttgg agatactcac caactatcaa caactatcac gcctagtgaa gcatctaaca 86700
aaaatgtgtc atttgaatca gacaaatcag gtgttgctag tgtaacatca gaaggattaa 86760
ttgaagcagt tagtgcagga acagctaata ttactgtaac tactgaggat ggtagtcata 86820
ctgatattgt tgcggtaaca gttaaggaac ctattcctga agcacctaca gatgtaacag 86880
ttgaacctgg tgaaaatagc gcagatatta ctgcatagga ggacaataaa gaatggaaaa 86940
gacattaaaa gtttatagta atggtgaagt tgtaggctct caagtagcta ataacgatgg 87000
agctactaca gtatctatta caggcttaga agccggaaaa acttatgcta agggagcttt 87060
taaagtagca tttgctaatg attcaggtga atcagaaaaa gtagatgttc ctgaatttac 87120
aactaaaact cctgctgaag aaccttcaga agaagcataa taattaagac caactaaaaa 87180
gttggtcttt ttttattgac aatttataat atctatgata cactatataa gaattaagaa 87240
aaggagggaa agtaatggat attccaacaa tattatttag aaatccatat gattacacaa 87300
aagtaaaaaa attaatggaa aacaaagaac agtacattgt agtaaaattt gattcagttt 87360
ctgttcataa tttaaatgtt caaggtatga tgaatgttat tcaagattac ctgcacatct 87420
atggttacag agtcaaagaa tacggacaag aaaatgcttc taaagatgat gaaagagacg 87480
ttaaaggtta cttatacgaa agagtaggtg agtaaggtat gggtgttata ataaattcta 87540
accatattca gtcagatact ttatatgagt acgatagttt ttttgatatt gagaaagtag 87600
atacgtttga agaaggatta ctatcaatac aggatgaacc aactgtttta gcaggattta 87660
tctatgatga tattacattt aataaggtta ttaactctaa ttcaaatatt gataacaata 87720
ttaagaataa tgatatttat tatgtttctg atatagggtt acttccggat acttttatca 87780
ctgttgattc taataaaaaa tactattcat tattacagca gatagttgag ttaagtaaag 87840
accctttccc taaatgggta gaaacggatg caaaagattt aactaggtat tataactttc 87900
aagattttga agatgtattc gatttaaata gtttttataa aaaagaagtt gacatggtaa 87960
gagaaaagtg ctataataat ggtaatgtat atttattata tgaagtcttg cctgattata 88020
aattacctct agcttatagt ttactttcaa ataaagagca tggtattgtt attatcggtt 88080
cacagacacg ttctaataat gatatactga ctttttacgt taaaggtatg gatgctaagg 88140
caatagctag catgtttaat gtagaacatg attatgattc taatattttt catacattcg 88200
taaatagtca cattaatatt ttaggaaatc aaataactaa gtttataaga gagaaaggaa 88260
gcagttatga gtaactataa aacaatagaa gaagtacaag cagttattat cggagtatta 88320
tttaaagatg aaggtaaaat tgtaacatct aagtttaata aaattactaa agagtttggt 88380
ttagatagaa ttggtaaaga cgaccttaaa gaaattgttg aagatattag acaagatgcc 88440
tatctaaatg agcttaagaa taaagcaatt aaaggtaagg taactttagg agaccttaaa 88500
gatgttgcag ataatcaagt attcgaaggt aataactatc atgaagaagt ctctacttat 88560
gtagtagcta aagaaaaaga actatctcac ttgagagaac aacgtaagca caacagacat 88620
accgcatacc ctcaaattat gtttgatgaa cttaaagaac atatggttaa agaattacaa 88680
ggggaaacat tagtagagca tcatggaagt aaagttaaca ttaatgatac agagttaatt 88740
gtattactat cagatttcca tattggaagt attgtatccg atatgactaa tggtaaatat 88800
gattttgaag tattgaagtc aagactaaat cactttattg atacgacagt taaagagatt 88860
gaggatagag agatttctaa tgtaactgtt tactttgttg gagacttagt agaacatatt 88920
aatatgagag acgttaacca ggcatttgaa acagagttta ctttagcaga acaaatctct 88980
aaaggtactc gattacttat tgatatctta aatgtactat ctaatgtagt tacaggagaa 89040
ttaagatttg gtattattgg tggtaatcat gaccgtatgc aaggtaacaa aaatcagaag 89100
atttataatg ataatattgc ttatgtagta ctagactctt tattgctatt ccaagagcag 89160
ggattattaa acggtataga tattattgat aatcgtgaag atatttatac tattagggat 89220
aatttcggag gtaaatctat tatcgttaac cacggtgatg gattaaaagg taaaggcaat 89280
catattaata aatttatctt agatagccat attgatttac taattacagg tcacgtacac 89340
catttctcag taaaacaaga agattttaat agaatgcata ttgtagcttc atctccgatg 89400
ggatataata attatgctaa agagctacat ttatcaaaaa ctaaaccttc acagcaatta 89460
ttatttgtaa ataaagaaaa taaagatatt gatattaaaa cagtattttt agattaagga 89520
tggttaataa atggatacaa tttttattat aggtgtagcg tttataactt ttgcaacatt 89580
taatatagtc tttagattat ttgatttatg gactacagag aagaaaatgg taagtcaagg 89640
acaacctcca ctaagtaatt ttgagtacta tcatgtgata gtaccctact tagttggtgt 89700
tattgttatt atactgagta ttatttttag agattccttg tattctgcgc aatcaggatt 89760
cggtgttatt attacaagct ttatttatat gctagtttat gttataatcg gtcttgtagg 89820
gtcgtttgta cttacaatat tccaagctag aaaggctaga cagtatcaaa cacaggagga 89880
taataatgaa gttcaatgat atttatgagc aattaattaa aaatgataca atacaaaaca 89940
ttcatgaatc tcaagatgat gaaggaaata tttatacaat acaatttgat aaaggtaatg 90000
ataagtattt atttaatgtt atcaatgatg gattcttgaa agaaatgaca aatggtatgg 90060
tagaccatcc taaaggtcaa ccatattcag taagtctaat caataaagaa actcctagta 90120
tgtcagtgaa acaatattta acagacgtag aagatattgt acctactatt agaaaaatgg 90180
aaaaggattt cttatagagt caagtcttta cttgactctt tttactatat atggtatatt 90240
aatatagagg tgacttaaaa atggatttta attttagtgc ttttgataat agctcattag 90300
caatgagaat tagtgagggt gtatactatt tcaatgatac cccttattac tttattgaac 90360
atatagaaga agaaatgtct gagtatgtta ttgtgtatga catacatgat agagaggaaa 90420
aagaaaatcc tcagaagaaa tatagagtag aaccttacca acggacaata cctggaggta 90480
cacctcttag taatttgatt aagagtatga tgcctcaacg taaatatcct aagaaggttg 90540
tagaagaccc tatatttgta gctaatgtta ttcctttagg aacagataca gttacaggta 90600
aaactggaaa aggttttttt gaaagagata aggatagaac tatttactca cagaaagaac 90660
caactaaggt agtccatggt caatacacag gtgttttcat aggtctaaca agtgttaaat 90720
ggaatagaac atatactcct ttagaaagtg ttgttgagta ttgcaagaga gtaaaaggag 90780
ataggttaaa tgtctaatga tgtagttaag ttttatgaaa aagatattaa agaccttata 90840
agaactaaaa aacacatgtt taaagacgat gagataacta gtgatataaa tgatatacgt 90900
atatttaatg agaaagtaat ttgtcaaggt aagtgtagaa cagattgctt agtactagac 90960
cgtaatggta ctgtcatggg tatagaaata aaaacggaaa gagattctac acagagatta 91020
aataaccaat taaaatatta tagtctagta tgtaagtatg tatatgtaat gtgccatgat 91080
aaacatgtac ctaaagtaga gcagatactt aaaagatata aacataatca tgtaggtata 91140
atgagttaca ttaattttaa aggtaaacct gttgtaggta aatataaaga tgctacacca 91200
tcaccacata gaagccctta tcatacaatg aatatactat ggaagacaaa tttaatgaca 91260
atacttaggt tgattagaga ccctcatact tatagaacag ggtatagtta taatgctagc 91320
ggtaggtata gtggtgggga aggcaacttc tctcaaacaa ctcaaagtaa aagaatgaaa 91380
aaacctgcta ttattaacca aataattcat tatgtagggg tagataatac ttataaactc 91440
tttacaagag gtgttattta tggttataat aatagatggg aagttataga agaagatttc 91500
tttaatacta tgaaaaatgg ggtaagagta atcaatgagc aaagacaaac caaatagacg 91560
taaagagata cagcatcaac ctgttaactt tgccccaaca aatactttaa caggagctaa 91620
taatagtttc tttgctaaaa agccctcaga acctaaggat acaacatctg ttattgaata 91680
tagaatactt tttattaaaa gatttgataa tgtaacaagt acagatgtta agttacaaaa 91740
aaaatatgca ttaaatctta ttagtgaggc acttgatgtt aaagaaactt atctatctct 91800
taaacaaaaa ggaaagaaaa cagaatctat tttacacaca gatagagttt attatgtgca 91860
tagaggtaaa aaacttattg gaaaatgtag tattagggag caaagaacat ttaaaggtaa 91920
acatttgata tttatattta agacaagaca tagagttaaa gcagaaagga aagataaata 91980
atgttaaaag gattttcaga acatgtagat aaacctacaa ctattaaaac cttatataag 92040
accttaacaa gtggtaaagt agaattacta ggtgtatctt atggtagtga ttacttccct 92100
tcaggtgtta cagtacaagc ttatattgaa gatataggta atgaagatga aggtctgcag 92160
tttgttaata aagtaaacgt agtggaatca atgaaacagg ctgtagtagg tatgaacaat 92220
caattaggtt cctcaggtct tggatatgtt agaactgaac aacttaaaaa agagctagaa 92280
gaaactggat taatgacaga tttacttgct agaggtacta acttaacttc tactaagaaa 92340
gtggatattg taagtacttt tattgagcct gaagtaacat atcaagacat tactatagct 92400
aaagatatta agttacgtct atacaaacta gaagaagagt caccattaaa cggttataca 92460
catattgtat atcttcttac tacagagaaa ttatatgatg gtcaaacact atttggtatg 92520
ctatctaaga aagataagtt atctaaagga gatactgata aattattagc attctttaga 92580
aataatagtt taataagtaa aagtgtattt tgtgttaagt tattaagtaa agactactac 92640
ttcaatttat ataatacaca tgaaacaggt atattctttt tagaagatac ggatattatt 92700
actattgctt gtggtcagtc atacgttaaa gttaatacta aagatattaa atctagtcat 92760
gttaaaattg aagatgagac tcataaatta actgagctag taattaactt aaaaggtgac 92820
gacacattaa ctattttatt ctaatagaat gttataaata tgtgataatt aagtataaat 92880
atacgttata tagaaagttt tcataatgtt tttaatacag aaactagtta agttttttac 92940
acttgtccta gtttctgtga aattatattt atgaaaagtt aaaatatctt ttaggtaaag 93000
gctttgtaaa tagttaaaaa atatattaaa attttataca aagtagttaa taaaattata 93060
ttacatttat atattatgaa ataataacag aaattgtgat atattatata gtgtaacctt 93120
gaaacagttg atgttgtagg gtttgtttat gttcgttaaa ctggtttcag aacatcagtt 93180
accataaata aatgacagtt aaggagagct atataatggc tagaaaaaag aatttacgaa 93240
ataaaaacag tgatataaaa gttgttcctg ataaagaaaa agaaagtata ttatctaagc 93300
tataccataa taaattacta cgctcaaagg tagataatgc tttagatgaa gatatgagtt 93360
atgatgatat tatagaacta tgtaaagaat atgatttaga attgtctaaa tcagctatta 93420
caagatacaa aagtaaaaga aaagaagcta ttgaaaatgg ttgggattta ggagaattaa 93480
ttgataaacg taaaaaaaca agcgtaaaag atattaagga aaaagaaact cctatattag 93540
aagaggagca actttctcca tttgaacaat caaaacatca cacacaaaca atctatgatg 93600
atattcaagt actagatatg attatttcta aaggtgcaaa aggattagaa tttgtggaaa 93660
ctttagaccc tgctttaatg atacgtgcaa tggaaactaa agataagatt accggaaacc 93720
aattaaaagg tatgtcattt attggactta gagaattaca attaaaacaa acagctcaag 93780
atacggctat gagtgaagta ttattagagt ttatacctga agaaaaacat gaagaggtat 93840
tacaacgatt agaagaacta caaaatgaat tctacaaaaa tctagattta gatgaagaaa 93900
gtagaaaatt aaaagaagct cttgatagag taggctatac aatttagata gtgaggttag 93960
agtaatggca gatgagatta gtttaaatcc aatacaagat gctaagccaa ttgatgatat 94020
agtagatatc atgacatact taaaaaacgg aaaagtactg agagttaaac aagacaacca 94080
aggggatatc cttgttagaa tgagtccagg gaaacataaa tttactgaag tatctagaga 94140
cttggataaa gaatcattct actataaaag acattgggtt ctctataatg tatctgttaa 94200
ctctcttata acatttgatg tttacctaga tgaagaatac tcagaaacaa ctaaggttaa 94260
gtatcctaaa gatactattg tagaatatac aagagaagac caagaaaaag atgttgctat 94320
gattaaagaa atacttacag ataataatgg taattatttc tatgcactta caggagaaac 94380
aatgctcttt gatgaaaata aattaaataa agttaaagat tagggttgac agttctgaaa 94440
gtatatgata tagtatatgt atactaaaaa taaaggagct aacaattatg tttatttcat 94500
taaatcaaga agagaaagaa ttattaacta aagaggaaaa caagtataca ccattagaaa 94560
catcaagaga gtttaacaca cctaaagaag aattcattgt aacaagttat aatgaaggta 94620
aacctttaga ttacattgca aaagaagcta aagtaagtat gggattaatt tacacagtct 94680
taaactacta taaagtaggt aagcgtaaca agaaatcacc tgtagaagaa agaattgcac 94740
atatcttgaa agacaaaaac ttagttaaag agattattaa ggattaccag tatatgaatt 94800
tacaggacat ttatagtaaa tataatcttc ataagaatgg tttatattac atcttggatt 94860
tataccatgt ggaaagaaaa tctgaactta aggacaaagc attggaagag gataatattg 94920
tcgttgagta agtaaagagg ttataatatg agaaataaaa aatcatttca agagcaatta 94980
aatgacatgc gtaataaaga gaaatgggta tctgaagagg agttcactga agaagtgact 95040
ccttctgaag aacctgaagt agaagaagaa aagttatata ctttaaatga gttaaaagaa 95100
aatttattgg atgctcaggg attaaaagat gttgtcgata attttcctgc atctaagcca 95160
gtatatgaat ctaataagct ttatatttgt acaataccaa aaggatatcg ttctacagaa 95220
gtacaaccag gtcaatatat tggtatcagt acagggttat tatcagaatc agaagatttt 95280
agtcatttaa gaggtcaaat gcctagaaat ctttatgaaa cttctcatgt tttaaaacct 95340
ttagtacgta ttaataatac aaatctcgaa tatcaacagc atgagttact tgaagatatt 95400
aaagatgaca agaagatata tgatgttgaa ttagaagacc tgaggttagt aacaggagaa 95460
gaaatatccc atttagaaat tgtcgatagt aagttttttg aaagtcgtat taatgaaatt 95520
ctcgaccgct atactgaatt aacggattcc gatgatttgc ttatatacta tagtaaatta 95580
cgagaattag taggcagtga caaaatgatt tattgctcac ttctagataa atgtgttaaa 95640
attatagatt aatagttagt ctcctcttat attataactg taagaggaga cattttttat 95700
agaggtgtta attatgtcaa gaaaagcaag tatattctat atactagtag ttattgtttt 95760
ggctttttct atttcatctt attatatatc ttctttcatg tatcacgaca aagcaaagaa 95820
tgaagtctct actgagttat caaacacggg aaagattaaa gaagaaaaga acgtagaatt 95880
tgtcggtgac tatacactta aaaaagtgga aaataataaa gcttacttta tggaaacatt 95940
acctacttac ctacccggta gaacaggaga taacagcata gatatgaggt actacaaaac 96000
aagtagattt aaagaagggg taaatttcaa gcttattagg gtatatactg aagatgggga 96060
agataatcca attcataagt ataggtttga agcagtacca accaaaaagt aataaggagg 96120
tgacttaaat gacaacatta attgtcgtca tctttattgc tatcatttat tacttatgga 96180
acagtgattg agtcaagtta attcttgact ctctttttgt tttatggtat attaatatat 96240
agaaaggaga gattaattat ggaaatggca gatttagaaa gatttgatac gtttgtaaga 96300
ttagtttcag acgatgagct ttcggaggaa agaatattag aattgagtgt agacttatta 96360
aatccgatac tagaaggagg tacagcttac caagctaaaa aacgcattag aagtaagttc 96420
ggtaaaatag aagcaaaaaa ctttaaaaga aattataaat tcttactcaa gtcgatagct 96480
caaatagacc aagggagata ggacaatgac agaaagggaa aagttagtta aagagattga 96540
agatgctaat agggacatac aattaaggtt aaaagaagta gatgattata aggatagtat 96600
acgttctaaa ggaacaagaa actatgtatc tactaaggta ttagattcag ttatggtagg 96660
gctaattata agtttcttta ttcttgtaat gttacgtgta cttgaatatt ttgtaacagg 96720
taatgctgtt tattcacctt tagcgcctgc agttattatt atgtttgttt tagccttagg 96780
tacatggaaa gtaagtaaaa tgaataaaat agtatcctac aggggaacta ttaaaatgta 96840
ttgggaatta agtaatgctg agcagaacca agctaagata tttaagtatc ctaatgatga 96900
agtagatatc gtatcaaaac ataacttaag acaaataact tttagtgaga ttaatatcct 96960
tcatcttaaa tatatgagat ataataaggc agtagaacag catactaagt tatctaaaga 97020
actttttaaa aaagataaag aaactattga caagaacaaa taagtgtagt atagtattac 97080
taaaggagga gagatattat ggttatacct agtattaaag cacaaaataa attcaagaat 97140
gaattagagt attataagca aggtcacatt agtgaaagta aaatgttaga attagctttt 97200
gattacattc aagaattaga acaaaataat gaatatgtta ctaatttgct agaagaggag 97260
agatatggtg agtaaattta tcggagtgta cttatttaat ttattagtag tagcgctaat 97320
ttatacagta ggatttttat tcttttatgg tgtagctagt ttagttatta ttataactca 97380
tgccactatt gacccatttg tattagctac tttcttagga ataggattct tggttattag 97440
aactgcacac agaatcatgg cacgagtaat caatgatgca gtagcccaag ccattaagga 97500
taaagaaaat gaataaaggg gaatttatta tggataaaac attaccaaag tttagtgtat 97560
atgaagttat tgtaaagact gtaattatga caccaacaga aggaagttct gaccgagaat 97620
cattttactt ttcaactcaa gagttagcag aaagatttgt taaagaaaac caagtagaaa 97680
caaaagatgg aaagcgtgta tctttttcta ttaaagagcg taaagtaaat caaccaggct 97740
aacattaatt tgttagcttt ttttattgac aaatcatttt atatagtgta tagtaatatt 97800
atactgaaaa ggaggaatta ttatgaaagt ttcagaagaa gtaaaacaga gctacttaga 97860
gaataaagct aatactaaaa tggataagat aagttggtct gagttaaggt ctagtcctgc 97920
aggtagaaca ttaggagact taatatactt tagtgtagtt ataataaata atatcatagc 97980
tatagcatta acattaatgc ttggagatat tatcaaagat ttaacggata gtaccctagt 98040
aaaaataata agtatattac ttattatcat cgttgtatac ggtatactat cggctttaat 98100
acctatacta atatttaaat ctgtatttcc tggatgggaa tatactgaat ggaataattc 98160
ttactatttg agattacctg gagaaaaaga ttataaatac tatagctact ggtatttaaa 98220
tttattaggt gttactgagt tttatcggac aaatgatgag ggtaaagaaa ttaaagaaac 98280
tagtttaagt tgggtttttt atactaaggt tgatagacct gaggatattg accattggaa 98340
aaatcaatta ataactaata gacctttaac aatttctgag tacaaaaaac taaagaagct 98400
agataaagaa agtgaaatta gaaaacaaga agatttagaa gaatacaagc aatacaatag 98460
taattaaaga ggtgaaaaac caatgataag ttcatttgat agtgtattac ttgtaatata 98520
cattattata gcttttgcag tagctatggc aatactttat ttagtattta aaggtatgac 98580
ccttttatta gataaactaa tgatgttatt actaagtaaa actaccttag atgtagaagc 98640
ttgctccatg ataatggcag tagtcagtac aattgtgttt ggaattattg tacttttaat 98700
atggttagca gtaaataata ttttattgta aggagtttta ctatggattt taatgacttt 98760
ataaacagtg aatcagatag agtgggtaaa cctaaacaaa agaagaaggt agaaaataaa 98820
ctaccttctt ctactcctat tgaagagaag gaaaaaatgt tgaaaagaat aagagaaaaa 98880
tcattataca ttgatttaag gagaaaaaga aatgactaaa gaaacaaatg tactttacaa 98940
agataagtat agagattata ctatagttgt aagactagta ggtaatatta ttgttactga 99000
agtagataag aagcataaaa caaaattttc acctattata tttgataatg gtcgagaagg 99060
tgtagagctt gtaatgcgta tcggctcaga agaacttgat atgaaagaac ttagagaatt 99120
tactaaagag gtatcaacag ctcagaaagc tttagaatat tttaataaaa aactttacat 99180
taaaggcttg acagatgaag ccttttaata tatactaaga ttataactaa aacaaagaaa 99240
agaggaatga ttattatgtt attaggaatt ttatggttta tatggggatt tgtatcttat 99300
tttgtagtga tgtttggaat tgaattttgg aaagacagat ggttaccagg agttattggt 99360
gcaggagttt tattaatatt cttattttgg attatgaagt ctattcataa tgctatgaca 99420
gtagtttact tgtattagga ggtaatatag atgaatatat tagttatcca ttatgaagaa 99480
acaaataaac gagttctaaa agaaacaata aaaacaatac aaaatcattt aaacgatgaa 99540
catggtttgg ttaaaatgac agcaacaaga cttagtagaa aagccataga agaagagttt 99600
aatgattaca atatagttat tgcagaaaat gaccctgata gtttttacag ctactcagat 99660
gcagtagacg atgtagattt tgttatagat ataccaattt catatttaga tatacatgca 99720
ggtgtagagt gggatgttga taatcctgta gatatgctag ataggaaccc tgattttata 99780
gaagctatgg gtcaattaaa cgaggactta atgttataag gaggaaataa aatgttaaat 99840
gaaaaactaa aaaatttaga agatacgaaa gtgtatatga ttaatagtat tgcaagttta 99900
ctaagtgcaa gtacaggtaa atcaagtaaa gtattttttg atgaaggaac tattaaaatt 99960
gtaagtggtg atacaaaagc ggtagaagtt attgataatt tagttcaccc tcattcagga 100020
cgtttaccta ttaaaacaac agaacgtatt gctcttggta gactaacaga ttctttacag 100080
tttgttattt cagaaataga gtcggttaaa gaccaaatta tagatgaaga aaatgaagct 100140
tacattgatt ttgtaatgga agactggaat tgggattaat gcctatggac ttaatgacaa 100200
tagcttctgt tgcctttata gctgtcgtta ttattgattt aattaatgat gatatgagct 100260
atatgttaac tggtactgca atattaataa acatttgggc aggtttttat ggatggttct 100320
ttttactaca agcaggtatg ctacttttct tactcttagc tagaaaagtt aaagatgata 100380
aggaatcaat actatactca ggtgcttcgt taatatgtgc attagggatg ataataaatc 100440
ttcttatatt ttcttaaaaa taagtgttga cacttctaaa cttttgtatt atactataag 100500
tataacaagt acaggagatg attaatatga gtaaagaaac aattagaaga caattttcaa 100560
acgcaattga gattatggca acaactaagg aatggtggaa tttccctaaa agctttaata 100620
caaataaaga gtttaaaatt aaaactttta aaaatgacac acttgtattt gaagttcgag 100680
aaggtaatag aaacttagga agctttgtag ttttcacatg tattgacttt gattatgata 100740
aacttgaagg aacttcaaca cagtatatga ttaattactt tgctaagaaa ttaactaaag 100800
atatgtttaa ctatcataag ttacaactat agtaggaggt ggaaagatga gagaggaatt 100860
aaaacctttt aatagaaaac aagttaatgt taaagggtac ttagatgatg ttaagtactc 100920
aaagcgtaga agacataaag gtaatcaaca tggatgtgta aaaataacag ttactgacgt 100980
aaagattaat ggtatatcta ttgaccatgt taatattgaa gttggaattt ctttttatga 101040
aaaactaaaa gaattacaag gaaaaagaat tcaatttgta ggtactgtct acaaatacgt 101100
taaacatgct agaggtcata aaggtagaat taaaggattt tataaagagg attatagtgt 101160
aactttggat aagaagttac aaaaggagga aaaataatga ttaaaagaag aaaacattta 101220
gaccatacag tacaacctga gaaaggatgg agaacagtac cttttaatgg ttactatgaa 101280
gcccaccctt caggtttaat tagaaataaa gtaacaagaa aactaattaa aggaacacag 101340
acaaggaaaa atcatcctaa gtggactgct catgagattg tatatttaat taaccctaag 101400
aaaacaagtt attcacgagg tgttgttatt gcacatacct ttcctgaaat gattagccaa 101460
tcacgaggag accttaagaa cggtcacgta tgttttaaag atggtgacag aagtaattgt 101520
catgtaaata atatgtttat tggtaaaggt aatgttaata agaatatcta caaattaaat 101580
gattcctatt tgactagaaa agatattgaa gaggatatca acaacttagt taatgagaga 101640
ctattctctc agttagagtt acttattaag aaaaatgaac ctgaaagaat tacacctagc 101700
aatcacttta ttaaaagaga taataatgta ttcagtatca cggatttatc taaaaactct 101760
ttagtagaat ttgaattaga aatcaaaaat attaaataag gtggctatat aaatgaatga 101820
gtggtatgct ttatgttact atgataaagt aggtaaaaag aaaataccta ggcaagttag 101880
agcacacaga gatatttcag tattagaaga gctaaaagaa agattagaag aaagaaatcc 101940
tagtacagaa tactctataa aaacaacaaa agaatttgat gaggagagat agggatgtta 102000
acaccacagc aaaaagattc attaaaaaag caacaaaaga aattaagtaa aaagaagaaa 102060
taactgttga caaatgagtg tacataggtt atacttaagt taacaaataa agaggaggta 102120
tgacctatgt tattcataat ttttttctta gcagtattct ttgtattagg atttattaac 102180
ggatggaact cagaagacta aaaaaggagt ggttatagtg aagttagaag ataaagtatt 102240
agaaagaatt gattctcttg gaggtaagtt aggtgatatt agccaacatg cttgggaagc 102300
tttagtaaag tatcaaatta tatatggtat tatagacctt atagtaggta ttatagttat 102360
agcattaact gtatttttat ggaagttatt tattaaccaa cataaaaagg taaatgatat 102420
agatagagat gatgattata gtttactatt tgaagattgt gaagatttat caggtatagg 102480
tttgttttat gtaatagcta catcaatcat atcactattt gcatttatat acttagtata 102540
tggaatacct atggatatta taaaaatact gaaccctgag gtatttgcag taaaagattt 102600
aatcgaacaa gctaaaggag gaaactaaaa tgaaacaaag agattttgaa tttgaggaag 102660
attttgtatt aacttacgag tgtgaggatt gcaaacattt tgaagattgg ggtcatgatg 102720
aagggcctga agaatgtagt gaatgtggta gtagtgactt aattaacaat acaagtcatg 102780
aagacactga gtgtgacatg tgtaaagggt acattgatat gtggcaagat ggatatagat 102840
acatgggaga taataaagca taccttgaaa aagaagattc aggtttaatt tgtgaagatt 102900
gttatgagaa attagatatt taataaggag gaaattaaaa tgaacaaagc agtagagcaa 102960
gcaagtagtg cattagggca aggtttttca gctatggtat ggcaccaggt gttagtaggt 103020
ttaggattta ttttactagg ggtgttatta tctttattag tttgggtact agtaaaaaaa 103080
ttacaggtac catttaacca tccaacagct tttgtagtat actcaattat gttagttagt 103140
attgttgcta gttttatttg gggtggttta cacgtaatta accctgagta ttatgctatt 103200
ttagaactta aagggtttat aaagtaggag gaattctatg actaaagaag agttagagca 103260
aagagtaaaa gaacttgaag cagagaataa agaacttaaa aaacaaatag aacgttttga 103320
agacgaggga ggaaaaacaa aagatgaata gtagacaaaa gaaaattcta acattaacaa 103380
taaataattt tttaatgtta gccttagata ctgtagcact aattagatat aaaaaaggta 103440
aaattaaaca agagaactat aatacaggac agattacaag aacaatagtt acaacagcta 103500
actcattagg tattctttac ttagaagaac aagagcgtaa agaagttaaa gatattaaaa 103560
taggtacttt tgaaactgga gaccttaaaa gatttatgaa tacaaataaa taaaaagttt 103620
aagaaaccta ttgacattag gtttctttta ttatatacta atattataag aaataaggag 103680
gttaacttat gaaaggtatt attatatttt acaaagaaga gaccaaagag gatttaggat 103740
attttcttgg gtttataaac tttaagctag aaggattatc ttacacaact gaaggtactt 103800
tagtagataa tgatgtagta gttttaaagg ataaccaaat taatgaggat aatttagaac 103860
agtttagtat gtcaaacaat aatttagtta ttggaatact aggtcattca tctctttcag 103920
tacgtatcta tgaaaaaggt attagacaag aaattgaaag agtagaagaa tatttagagg 103980
agttgagaca ataatgttag caatatttgc attaattttt ggtttactat ttattttatc 104040
tttattaggt atttttattt attctatatt tttacgaaag aaaaaacaat taatagaaga 104100
aagagaatca tttggtattt ataatagaac gaaagaaaaa ctgggtgatg taacacgttt 104160
agggtatgag gaagatgtat ataagttaat ccataaccaa tctaataaga caatcataga 104220
ggataaaaag agtaaagttg tagatacaat taaaaagatg tatgaattag aattaacatc 104280
tgtagatgtt tctaaggtag aaggattatc tccactcgat acagaaccta tgacaaatat 104340
gaaattactt tcatataaga tagatagaga aggattatat agtttgagta aatttattta 104400
ggagtgatac aatggaattt atagataaaa ataatgtgat taaagcttac gatataccaa 104460
atgtttattt aaaaggttat gtattacagg catgtgataa aaatggagat acaacagctt 104520
atgatggtta tgaccaaata cactataaaa aaggtagagt attaacattc ccttttgata 104580
aaccattaag aaagataaat gtactatcag gatattacaa actatttaaa aaggaggaca 104640
taatatgatt tattttgtta gtgatttaca ttttggtcat gataatatta gagaatttga 104700
agcacctaca agaagtcact ggaactcagt agaagagatg gatgaaggtt taattgagtt 104760
gtggaataat acaattacaa ataacgatat tgtttataat attggagact tctttttcaa 104820
tatgaaaccg tctaaagtag aagatatact taatagacta aattacaaag agatgatact 104880
gattgcaggt aaccatgacc ataagaaact tataaaacta tatgaacgta atggtattac 104940
agtaaagtac gcagatatga ttaaaaagga tggtaaaaga ttttatctaa gccattaccc 105000
tacgctaata ggtagaaaaa acatgtttaa tattcatggt catatacatt cacagttaat 105060
ggatacagag tatcacatta atgtaggtta tgatgtagag ggtaagattg cctatagttt 105120
tgatgatatt ataagtagag caggtgaata taatggagaa attcaaaggt aaagatttat 105180
ataaaactag aattagaaag caaacaatta aaaatttagt tataaaaaca gagaagctac 105240
ataataaaca tggaaagtat agacctatcg gtcatgtcta ttattacccg aaaacaaaag 105300
agtttacttt atccaaacct gagcagaaaa tatttataga gtacatgaag gcattaggtt 105360
ttagtgttaa acacaagaga cgtaagaaaa taattatagt atacaagaat gtgttagatg 105420
aatatcttag tatgtatcag gaagcaattg aaagtacgtg ttgacaatta aggtatacta 105480
tgttatagta tagaaaagga ggttaactga tgaagcattt tattttgatt ttaggaattg 105540
taattctagt tattgcatta ggtattgttt tacctgcatg gattttacaa ttagtgttat 105600
ctgcatttgg tgttaaagta agtatttggg tatgtatcgg gatatttatc ttaatcagtg 105660
cagtaggaag tatgtttagt agaaattaaa ggaggaacta taaatggcaa aatatgaatc 105720
aaatatcaac ggagaaaatt atattgcaac accatcacaa gctttaagag aggcactagc 105780
agaattaatt aaagaagaaa agaactttgc agattaccaa actaagggtg aggaacagta 105840
tgaatcacag ttacaactaa gacacttcga tgcaatgatt tctcagtatg aagaagctat 105900
tcgagtatta gaggatagat atttatctca gatttttatt ccaaaagata ataaggagga 105960
aaagtaatta tgaaagcaga gtcaatagca cgattttttc aggataaggt attacaaata 106020
gaagggtata aggtaagatt cactcaagct agttcatcat atattttaga tatagatact 106080
atggatgaat cagtattgtt tttagatact gtagttttca ctctatcagg caagtactta 106140
ttagatacac atattacgat taataaacct gaaacactaa gctctaagga attatacaca 106200
gagattggta ataaactaca agagattgta ggagaccaaa cgaaaacaga tatcgaatta 106260
actcgatact ttaaggaggt aaaataaatg aaatcagatg ctattataaa ttcattatta 106320
aatatgaaac atataaatat acaaaaacac aatataaaag taacacttga gaaaggtaga 106380
tataagggtg tagggtatct aatagagttt gaaacctcaa tacaatacag aaataattat 106440
aaattacaat ctccaataat tatatcttac gaaaatgaag agcctaaaga aatcattact 106500
caaattaaag ataaagtatt gaaaattgta gaagagcaga taaagacaga tgatttattt 106560
attgaagcaa ttgatgatat taataaggag acagctctta gaaaactaaa gccttatatt 106620
aatgaagaat actactcagt gtttaaatca tctattgata agggagtacc tgtagtttta 106680
ccttctgaac ttttagatag atgcacagga aaaacatcaa caatggctta tttagctata 106740
gaatatgatt tacctcttat agtatcaaac acagtcatgg ttagagtgct attaaatgat 106800
tatccgacta ttaaagttac atcgaaaaaa agagaaggtt acaaagactc aatagtgtta 106860
attgacgagc ctgactctga aatactaaat ctttacttag gtatgcctga gtgtgatatt 106920
attggtatta cgaaaaaata aataaattta taaatacctg ttgacaacag gtatttttta 106980
tagtatactt tagatataaa gaaaaaggag aggttaacat gaataacaaa caaattgaaa 107040
gattacacaa gaaagcaaac gaggtagtaa gtaaatcaga agatattgaa gatttaggtt 107100
atgtgcaggc acataaaatt attaaaggat atcttgattt accagtgtct gattttgaaa 107160
agagagatgt aatgactgaa ttactattag cgttagataa agctaataaa tctatagatt 107220
aataaggggg tagtaatatg gtagatatta taattttaat tgtcggttta atattatttt 107280
tagctagcgg atataaatta gttttaggta aatattatga taacacagat ttaaaaatgt 107340
tatttacaat ctttggtatc ggtactatac tattacttgt aggatttata ttataaagga 107400
ggaaattata aatgaactat aaagaagtac tagaagttat taaaaagaat aagccatgta 107460
aggttagatt tactggaagt attttagcaa ttgttaataa ggaatttaac gcagatactg 107520
ataaaggtgt gttacaaatt gatgtatcaa atattaataa aaatgactac attaagttac 107580
aacagtattg tttagaaaga gatgattata ctgtagcagg agctatttta ttttaagggg 107640
gagtaattat gaattataga gattttatta cggattgtat tagcgggggt tataacgtcc 107700
acattagtgt tactgagaaa agagttcata ttatttcaga aatgacatca gcatcttatc 107760
cgaagaaaga aattaatttg gatgaactgc aagcttatgt ttattatatg aataattttg 107820
gaagtcagat tacaacggag ggattataaa tggaattagt tattaatatt atagcagtat 107880
taattggtat gtacggtatt tacttttatg ttacaaaatt tagtactggt ctatcaggta 107940
ttttaattgt actaggtatg gctgtaggtc tttactttta cttagattac ttaaatgtta 108000
gagagaatgt tattcgatta gtatctgtaa tgtttggtgc tttcttattt agtatcgaga 108060
tgatttataa taagattatg ttcgaaatta aaaaatctaa gtatgataag actgttagaa 108120
cgtacagagg agaccaataa gaattttact ataaagagta cttaaaatag gttaagtgct 108180
ctatatggta ccttaaaatg gcttagaatt gaaattaagg agatgaaaag ttatgtatcc 108240
tgatataggt gagttagctt ataaattaaa aagtactaga gaaagactag aaggtattat 108300
gatggaggaa gtttgggaaa tacatcatag agagacagga aaattagttt ttaaaggtgg 108360
atacttagaa gtaaaagaaa tattaagaaa aatgtataag gagaatttaa cattagtaga 108420
tgtagacaca atgttaaata tcggtcaagg gttttttgat gttgctaaaa gtatatcagc 108480
agaaaatgta tttcaaataa actataaaaa ggagttacca cgatgattaa agtattttca 108540
gaaatggata caaaatataa aacgattgta ccggagaaat tccctaatgg agaaattaat 108600
tttaaatatg atgacctaaa atatttagta gaaggagaac tatggtttga tgttttcttt 108660
aaatgggaaa ctgatgcaga cttaatgcat ttgtatatgt ttactaagta tctagaacaa 108720
ttaggtatta aaaataatgt ttccttcctg gaaattgcgt atttacctta tagtagaatg 108780
gatagagtag aagaaggtca tagcaatatg tttagtctta agtatattgc agaatttatt 108840
aacaatctta attataaatc tgtgttgata gcagaagctc atagccctgt cacagaaaat 108900
ctaattaaaa attctgtttc tataggtgtc acacttaaat tattagacca atatattgaa 108960
atgtctgaag aacctgtaac aattgtacta ccggataaag gagcttatga caggtaccta 109020
tctgatgtgg aagacatctt aagggattcc aatattgaaa attattcaat tgtatatggt 109080
gaaaagaaac gtgattttga aacaggtaaa attaaaggta ttaaaattgt taaggataaa 109140
aatactttat atgataactg tattatacta gatgatttaa caagttatgg tggtacattt 109200
gtaggttgta aaaaagccct tgacaatctt aaggtaaata gtgtatcatt aatattgacc 109260
catgcagaga aagtatttaa aaacggtaaa ttactcgatt caggatttaa agatattatt 109320
gtaacagact caatgttacc tgatagccag tgggaaaaag ctattgctaa acatagagca 109380
caagaaaacg gaacagaatt acaaataaag agtatcgaaa gatatctata aaaggagaag 109440
aataaactat gctaaatcca acattaatgt gtgactttta taaattaagt cacagagaac 109500
aataccctga aggtacagaa attgtataca gtacacttgt acctagaagt aataagtact 109560
atgaacatag tgataatatt gtagtatttg gtattcaatc acttgttaaa aaatatttta 109620
ttgatatgtt taataaagaa ttctttaata gacctaaaga ggaagttatt aatgaatata 109680
aacgtacagt taaattcaca ttaggacaag aaaaccctga cgctaaacat ttagagcagt 109740
tacatgacct aggttactta cctattgatg taagagcttt aaaggaaggt acagtagttc 109800
accctaatac acctgttatg acaattgaaa atactcactc agatttcttt tggctaacta 109860
actatttaga aactattatt agtactcaaa catggcaagc aatgactagt gctacactag 109920
catatgatat gcgtaaaatg ttagataagt atgcattaga aacagtaggt aatattgaag 109980
cagtagattt ccaaggacat gactttagta tgcgtggaat gagttcatta gaaacagctc 110040
aattaagctc agcaggacat gcaattagtt ttaaaggtag tgacactgta cctgtagtag 110100
actttttaga atcttactac aatgcagatg tagaaaaaga aatggttgtt gcttccatcc 110160
ctgctactga acattcggtt atgtgtgcaa atggtgatta cgagacaatg gatgaatatg 110220
aaacatacaa acgtatgtta acagaaattt atccaacagg agtattctct attgtatctg 110280
atacttggga cttttggggt aatatgacta aaactttacc taggttaaaa gatattatta 110340
tggaacgtga cggtaaagta gtaatcagac ctgatagtgg agaccctgtt aagattattt 110400
gtggtgaccc tgatgcagat actgagtatg aacgtaaagg tgctgtagaa gtactttggg 110460
atacttttgg aggtactgaa actgaaaaag gatataaagt actagatgaa catgtaggat 110520
taatctatgg tgattctatt aactatgagc gtgctcagca aatttgtgag ggattaaaag 110580
caaaaggttt tgcaagtatt aacgttgtat taggtgtagg tagtttctct tatcaattta 110640
atactcgtga tactcatggg tttgcaatca aagcaacata tgctaagatt aaaaatgaag 110700
agaaacttat ctataagaat cctaaaacag acagtggtaa acgttcacat aaaggtagag 110760
tagctgttta caaagatggt tcatgggaag ataacctaaa tcttcaccag tggttaaata 110820
aacagaattt aaatcaatta gaacgagtat ttgaagacgg taaactatac agagaccagt 110880
cactaagtga aattagagaa agaattaaaa ataattaata aatatttaaa ctccctattg 110940
acaaagggag ttttttatta tatagtataa ctatagtaaa taaaggagtg aaagagatga 111000
tttataaaat atcaaaacat aattattata gtaggtttga gtattctact taccctcctg 111060
atgaagggtt tgcgtatgta gattatgtag atgtgattct tatcggtgta gataatccta 111120
agaaaaaaaa ggttattacc ttaaaagtaa atgagttcaa ttcggatgac tataaagtag 111180
gtcataagta caatattata aaaatactat ggtttgaaaa atgggaatgg ttaaagccat 111240
aagtaaaagg agagaaataa aatgattata gataaattaa atggagttaa actagaaata 111300
agcggtcatg tcgtatcatt tagtgtaaga aagtttgata caattaatgg tgagagacaa 111360
ttaatagact accatcatat taaaagaaat agacaaaagt actttagaac tactgaagaa 111420
ttttataatg aatataaaga aattaagcct gacaaaaatg aaatagatga aatgtttgaa 111480
tctctaggtt acgtagatac tgagttagat gatgtagtaa gacacctgga aaaggttact 111540
gaaatattag gagttagtga acaatattta aatcagttat cttataaagc tatagaagag 111600
tatgtagata aagtagttac acttgaaatt aaagagttga aaggagagaa atagcatgaa 111660
taataactgg gaaaaagaaa gggttaacta ttgggaaaac gaagactgtc cgagggaata 111720
cttagaaaaa gcattcattg acctagtaga atatgtcgaa ggagttacag tatcatctaa 111780
agatgttaag cagttaagag aagataaact tagagaagat attgggtttt atgagtacgt 111840
agctgataaa taaattagta tctacctatt gacttaggta gatatctatt atataatagt 111900
atacaaggag atgaaaatat gaaaaagtta atagtattac ttacaattac tatttctcta 111960
ttactaggag gttgctctcc tgataaccat gagggtaaag tagtaggggt aggtgaatac 112020
agagaaccaa ctacttatat aaaatcaggt agcgttactg tcccagtcat tggtgaaatg 112080
aaatattatg tagatttaga gacagataaa ggagaagacc gtgtatatct taataaagag 112140
gtctatcata agtttgataa aggtgatggt ttctctaatg taggtaagaa agtgtacaag 112200
aatgatgaat taatatataa aggagactaa gtagtatgac acaatttata catgataaga 112260
aagatagtta taatagtaca aatcgtaatt ttgatactca atattataaa aatatacctt 112320
tacaacaaat tgataggggc tatggtcaag caaaagctag gaggtttaca ataaataata 112380
cgaaccaaaa tatatggata cctatgacat atttaagacc taacggtact cttaaaaata 112440
atattgatat agattggata tttgttaaag aaaaaaatag tttaaagaaa gcaggattag 112500
aaataaaaat agaaattaca gaaggtggat tataatgtat atactagaga gaacaattaa 112560
aggttttgta ggtcaaaaag atgatatctt accttattac ttcagaagta aaagggaaat 112620
tgttcatttc ttaaaattaa tggaattccg taagaaagaa acaaattatt gggttaaaaa 112680
gaatggtgat tttactatta taataagagc taaaaaatta ttatatattg aagaatatat 112740
acaaaaacta aaggagtggg aaaatgactt atgatgtgtt tgtattatac aaaagaagag 112800
aacctattgc acaaggtagt atggaacatt gtttagatgt ctattattgg gaaagattac 112860
atggatatag taataaaggg tatgagctat tacctataga atatgaccag gaggaacaat 112920
tatgaatagt acaaaattag tagattattt tacaagtaaa caaggtaaat atctaatatt 112980
acctgatgaa actaaagtta ggttatctaa tgtagattta atgtcttaca ttatgagact 113040
cacttttact tataacacag aagttgtgtc tatagatatt gataagttat actcagattc 113100
tatagaaatg catataccac aaggtcttta tatgacaact gttgttaaaa ttcctaatac 113160
acagagtgtt agttcagttc ttcataaggt attagaggaa tgggtaagac aagtacaaaa 113220
tgatggtata ttcggattcg tatgggagga attttaatgt atagattttt attgtttagc 113280
tattctgatt attacccttg cggtgggatg gatgatgtag agcttaagtt taatggtttt 113340
tctgagttaa taagtaacaa agatgatttg tatttaagtg aaaatattga aatatacgat 113400
actaagtatg acaatatact atatattagt aacaaagaaa cgatattaag tgaatttaga 113460
gactatttag gataatggta aaaataatta aaaaataaag gagaaatgta aaatggcaag 113520
agaagctaaa caaacagtaa atacattatt acaaagatac agaacagcat taagagcaaa 113580
gaaaattatt tttaacttaa cagatgacca aattgaagaa atggacttag aagtaacact 113640
tactacaaag tatagtaata gtgtgacaaa tcaggtaatt aaaggtactg acaaggatgt 113700
ttcaatgctt atcctgattt taagtaacga agaatttaat gataaggtta ttaatattga 113760
aattgaagaa atcaatatta ttttataaaa actttaactc tattaagaga agggcaacta 113820
gtatttaatt ttaaatggga ggaattaata tgataaatag atataaaaag gtatgggatg 113880
aaataaccca acaaattgtt aatgtagaaa ttattaactt taaaaatgaa acagtaacaa 113940
tagaatctac agatgattca ggattatcag agataagagg ttttgaagaa gtagagttta 114000
tagattacta tggataagat gtttaaagta tataatttat aaggaggaaa catatggact 114060
tgtttgcaaa aataattatt atgtctatag gagttgtccc tttaattaca tttatggtat 114120
gtttagctat aacagattat tataatagac attaggacta ataggagtat gttgactaat 114180
aaggaagata tataggagag gagttaatca agtaaaacca ataaaatcaa ttaaaaccaa 114240
gtaaagtaac taaacaatac ctagagcctg ggaaaacttt tacctctccc actcagccta 114300
ttacttacta ccgacttccc taactatgta ttctatagtt ataatattca tttattatac 114360
aatacttaaa ctatagtatt gtaaccttaa tctatactga agcggtatta atctattgtt 114420
attatataat aatcttatat aatggtggta taatctaggt tattacatta gaatcattct 114480
aatctagaat tttaatcttt agaccctagg aaaagtggta ctaaaatata gaaccctata 114540
ggtatgggat tcttattttt aaaattacta aaaagtatta ggttttccct agggtaaagt 114600
tttaatgtac ctaaaatcgt aagtagctcc ttatcattta ggtctgttta attgagaata 114660
ttagaagata tccgcttcaa ttacaattaa aggttgacaa ctatgaagcg gtatgttata 114720
cttagtattg taggggtggt tccctacaga cctagactat ggtcgtgatt ttggtttgca 114780
tattagtgtc attcataacc tctattccag taggggttat ttttatttaa gtgttgacat 114840
actctaagta gtatggtatg attagtatat aaggagatga ataatatgat tgatatatac 114900
ttaggggaaa actataatac tgattactta tctactatta tgaatattat aaagacttcc 114960
gcttcaagag agttaagtta tgggtttaat aataaagaag cggatgtaaa tatagaggat 115020
atgaagtatg aaggtgatgt tctgcatgta tatggtacga tgtctatgga ttatccaggc 115080
tgtattatta tatgtattac tagagatgag actaaggtta tacatggtgg taactttcta 115140
acaggtacag gtcttagtca agaagttaga gaaaaattct agggggagtt attatgatta 115200
taccattaat tatattcatg atgaccttcg gtacatttgc attcagttat gttgcacatg 115260
atgcatacaa agtagatgaa aaaggtatca tgtatgctat ggtagttggt attgtagtta 115320
taaatgggat tggtttagaa atgataattg tagaatgttt ataaaggagg tagtaaaatg 115380
ataggtcaaa ttatactatt agctattgtt agtatagtta caataggttg tgtaggatta 115440
tttttctatg agacgttcaa gagtattaag tatgatgcta atgataaaat ctttatgatt 115500
actgggagta tattaatgtt agttattatc gttagtggtg cattagctat acttggcatt 115560
tagagctcat ttaagaagcg gttaagtagt tcatgataaa ttggtctaga aatatatgac 115620
cgcttctcta tagaaggctg agagggttta gaattgaaag gagagatata atggctatat 115680
tttttagtat tttattattg attaacatat acttaatata ctatgaatgt acttcagtta 115740
cgtttgattg gtgtgcactg cttatttacg tatgctcatt atgctcttgt atttatttaa 115800
tagtatattt tgtataaaag gaggagatat aatgcaagca actatatact gtgctaatag 115860
gtatagtaaa aatacattaa agagtctttt agaaaaatta gaagcggaga atagaaactt 115920
aacatatagt actgacatat cagatatgga ggaagtggat gttattgtac aacacactga 115980
cttatctttt gcagagttaa tggattcttg tgatagagta agtaaagggt ctgaccgctt 116040
ccaagtattt gtaggtaatc acgcagggta ttatataaac ggtgatttat atattaacga 116100
agtaggtaag tttattgtac ctaggaaaac gaatatgatg atgtaaggag gaaatataat 116160
gattcatata tttgtaaaag aggattataa taaagaaaca ttaaggagtt tacttgaata 116220
tattaatgat actgtaggta gggaattaac ttatggtatt aatacagact atgataagga 116280
tgtagtgatt gaaaccgatg accctataga tgaggagaat acgattgatt tatcaaatct 116340
tcctcacttt aaagatgact tatgtattct tatagaagaa ttatactgta aggcatttgt 116400
taatggggaa cctattatta tacgtaagta tgtagagggg atgttataat gattataata 116460
tttttaactg aaaaatatga tgccaaggct ttaaagaaag tattagaaca tattgataat 116520
tgtagtagca gaggtcttag ctatttaatg ggaaaaggag aagcggatgt atgtatagag 116580
aagaatgtat tcagagaaag agatgatgta aggattaact caaacattat tgatgaaggt 116640
aaactttgta tactcataaa taaaaatggt ttagaatgta gttactatag aggtgtatca 116700
tgtaatattg gtgcctttgt aaaggagaga ttataatgat agaaatatat ctcagtgaaa 116760
actatgatag ggatttactc aaagcagaat taaaatggat taaagagacc gcttcaagag 116820
aactaactta tgatgttaat agaagcccag gattagatgt acatattagt ccttttagat 116880
ataccaagga tgaggttgaa gaaatgagct tacatcctca gtttgaagat gatgtatgtg 116940
tatttatagc tgaaacatgg atacatgagt atcgtaatgg taaatcaata ggtgtagata 117000
gtatggaaga atatgtaaag gagatgtaat taatggtaga aacttattat acagtatatc 117060
ataagaatag tatgaaaact attaaggatt acttaagtag aagtgattta attgacttct 117120
tatataagac ttggcataag gatataagta atatataccc aacagattat actacgtatg 117180
aaacaaaatt ctgtatagac atagatgtag ttagattaat tgaagcggtt aatgaagaag 117240
ggatactact tattaaccat ggtaattatg ttacgataag agagtattag gagggagata 117300
aatatgaatc agtttttcac atatacagtg tatcaccaag attcaggtaa agtagtagct 117360
aaggatttgt ttgaggcatc cttggtgcac cttattaata agatgaagaa tgaagattta 117420
gttaaggata ttaatttaga atattacatg aatacacgtg gtgtagttat agatatgagt 117480
agactactgg atgatataga atcacagggt gtatttttat ttaaacgtaa gatacatgga 117540
taggatgttg acaaattgta agtagtatgt tatactcttc taaaggagga gtataaatgg 117600
aagaaaaatg gattattaca gaattagtaa atacagatta tccaaataga aaatactatg 117660
tatcaaattt aggtagggtt aaagaagtag gtacaagtag tgagaagatt atctttgacc 117720
ctgataaacg taacgtaact aaccctagaa gcggacatag attccactta caaaggaaag 117780
ctattaaagt tagaaagtta gtttaccata gctttaataa gataccatta tcaaaaagag 117840
ttaaaattaa aagtttagat ggtgatgttc ttaatgttag gttggataac atttgggata 117900
agtcaaataa aagtaggatg caacaggata gtaggataga cttgggatgt aaagaggtta 117960
gggttaaatt taagatagga tgcaaggatg atagaatacc ttgtgactat gagtattggg 118020
ttgagatgga ttttataagt gagaaatttc ctagtaaggt atattatata tctgatatgg 118080
gtcgtattgt ctcttatgat aaggatacag gaaactataa gatagaagta gatacctata 118140
atcagaagcg gaaagctgac ggaggttatt atgtttgggg tataaataaa gttgtttata 118200
aaattcatag gttagtagct agttattttc atcatacacc tattacatca gatttagatg 118260
tacatcataa gaatgggata aagactgata acagagcttg taacttagaa tgggttaacc 118320
ctttagaaca tagtaaagct catatggaac atgaagtagt cggtaataaa attagagaga 118380
ataataagaa gaaccgtaaa tactcttggg atacaatatg taagatacgt aagatgtatg 118440
aagaggataa gatgactaaa agtgagatag ctcaagtagt aggtattgat tttggcacga 118500
taagacagat tgtgaactat gatacctata aaactgaata aaagacaagt agtagaggct 118560
gttttcagtc tcttttttta taggaaatga aatatattgt aagtaactct ttatttttaa 118620
agcaagaatt gcctaagtag tcctctttta tttaggttag aatgttgact aagtagttct 118680
cttttattta ggttagaatg ttgactaagt agttctcgat ttttttcccc tagtcccaac 118740
cgcttcaagc agaccgcaaa aagaatcccc aggaattata ttcccaggga tttctataat 118800
ttttttatat attaaacttc gtattcaaat tcgtatgcat ctaattcatc caaccactca 118860
ataactctca cttgctcagt ttcccaattt tcatattgaa ctgattcaaa agtcgaacgg 118920
tagggacttt gtaccaggtg cccgattgtt tccccttcaa gtctaaccag tacgttgtca 118980
ttttctttgt agaactcgta agagtgacct cggaacgttt ggctaattgc tagaccattt 119040
tcaagccctt caaaaaattc aatcagttgt gtgttatcat tgttataaat aatcatattg 119100
tatcaatcct tttctgtttt ggtgttaagg tcgtttgatt accttacaaa tacaattata 119160
acagattagg ggggaattgc aatagttttg aacaaattaa atgagaaatt ttacacttta 119220
tgacaattta aaaaagtgta aaattggtgc ttgacaaatc ggtgtttttc ctttatcata 119280
ataattggag aggtctgtct gtcttatata taggttaagg tcgatctata ggttgtgcac 119340
aactaaatta atctattata ctatttattt tttgcttaat ttccggtttc ttccattaga 119400
aacaaaaaat aggctttaaa agttttttaa aaaagttgtc taaacctatt gcaatttact 119460
ctcaatttga tataatagta tttgtaaggc aatcaagaac acgaagggaa ttgatttaaa 119520
tggaaataaa acagattgca gacaatataa tggaactatg gcagatggat ggatacagat 119580
gttcagaacc accattatat gaaagcacac taaaccacac acgcactcac acggcgttaa 119640
tcgtgagcgt taagggaaac tatgaaactg ttcagatgtt ccgcaaaacg cctctcatga 119700
gcttgagagg gcaaagccaa ccggctagta tgttggtcaa tgtaattgat gatattatta 119760
ttatcattta tgaaaatacg gtttatggag tgaaagataa agaaataaaa tttattgaag 119820
aaatttaaaa ttaggggttg caatacccct taagatgtag taatataata gatgtaaggg 119880
aaagcaacac accttaaaaa cttttaaaaa aagttaaaga aaagtgttga caatttacaa 119940
gatacatgtt attattaaga taacaaataa gacaagccac ctagcaaata acgaaattaa 120000
ataaaaaaat tatagaatag gatttgatta ttatgacaaa caaaaattat ttatacacag 120060
aaacgcacac agtacaaggg aaagaaattg aagtgtttag aatacctaat gacgtaaacg 120120
gcaacccacg ttacgtggtg gacttctacg accttggtat cggtttatgg gactatgaca 120180
acatcaataa gctatacggc tttaataaat accgtgctaa atggtttggc ggtggtgtag 120240
tatttcaaag ctataatatc gaagatacat taaattttgc actagataaa gttaaagaaa 120300
tagaagcggt taagaattaa aaccgcttct gaattaaata aaaaaattat ataataaaaa 120360
ggtggttaat tatgataaaa atagatatgt taaatgtaac taatgaggaa cacgaaaatt 120420
gcataaatga attaatggat ttaaataata gtttcgaaag ttattatatt gatgacaatg 120480
cattaattcc tatatatgat aatgaagaat tattaaatgc ttatgaatat ataacaacag 120540
aattttattt tgatattaat gatataacta attatgatat agaatattta aacgattacg 120600
ttagaactgt ataaaaaaat tatacaattc cctgggatta aattcctagg gatttttatt 120660
tgttttaatt tatataaaaa aattatttaa taaataaatt agtgtaaaat tgatacttga 120720
caaacattga aaaatagcgt ataattaaag tgagatgact tttttatata taaaaaagtt 120780
tttgtattct taaattattg tataaaaaat tatataaatg aatttagtcg gggtctttcc 120840
cggaaccttt tctcttatat agcggacacg taggctcctt accgctttct tactatatat 120900
atagtatata ataaaaaagg gaaaaggtca acccttttcc ttaaattctt ttaaaatatt 120960
ttctattgtc atattctttt ttacaatcct agtatatagt ttaccatatt ttatatttaa 121020
ctctttagac cattgagaaa tattttgtgt cctaccttga tattcaactt gtatattatt 121080
agttctatta ttttgttgtg tatattggtt tacccaccta cagttattag gctcatagtt 121140
tccattatta tctattctat caattgttag agtatcattg taaccgttag cgtatgacca 121200
attggcaaag ctctcaagac tatttaacca ctcatcacaa acccttatac ctctagcacc 121260
ataatcctta taatgtttta ctcttttgtc ataacaacgt cttttcattg ctctatggat 121320
ttcaaatagt cttgtatttg aaagatgatg agtttcaagc tctttgcttt gtttccttgc 121380
attatctttt ctataacaac cacatgactt agtacgacca ttcacaagat aatcaaatct 121440
aattactttc atattgccac actcacattg acaatttaac catgttgaac atctaccctt 121500
aacttctccg tttacagatt taatagttaa tctattatat tttttattta tataattttc 121560
aatgttttct attcttttca tataatattc ctcctagttt ttgattctct cttttattat 121620
ataataattt gcccctaaag tcaagaactt tctttcaaat aatttattta aaaaagttta 121680
caaaaagggt tgacttattt tgtactatgg tgtaatatat aaagtgtagt aaggaagcgg 121740
aggaaataac ctaaaaaaag aatttaaaaa acttttaaaa aggtgttgac aaacttccaa 121800
atacatgata atattaagat agttagaaaa acaaaaaaac gaaaaggaat tgataattat 121860
gaacagatta gaaatagtaa aagatacggc aatggaatat atccttatga tggataatag 121920
cgttatggac ggcgttatga cacaagagga atacaacgaa gcggttagct ttgaaaaggt 121980
gtatgactac actctatcag aagcaaatca agaatgtaaa ttcttaggtg gtaaggtttt 122040
aactttccta gtacatgaag caatcgaaga atacgcataa aaaaacttaa taaaaggggt 122100
tgacattcaa cccctaccat gttaatatta atatatacca aatgagagga attgataatt 122160
atgagatacg aaattgtaac gttagttaat caagaattgt ttatgtatgc aacattcaac 122220
aagcaggaag cagaagccaa atatcaagaa tggtgtgact tatatggtca agaaaatgta 122280
agcatggaaa aaaattaaaa taagctgttg acaaactaac cgcttcatga taatattaaa 122340
ctatactaaa gaaaaggaaa tgattacaat gacaaaaaca atcaaacaat tagaaagcca 122400
attagagagt ctagaaagaa aatcagatga ggaattagca aacggatact atgacagatt 122460
tgaaagaact tgtgcacaga ttagagaatt agacctacaa atcgaattaa aaaagaactc 122520
agaaactgtt taaaaaaatc taaataaggg gttgacactt aaccccttag atgttattat 122580
taatatatac taaagaaaag gaaatgatga aaatgaaatt attaaacaga gacaacgaaa 122640
tcgtaatttg cctagcaaca cttgagagtg tcaaacatgc tctaatttgg gagtatctcg 122700
accatttaga taataacgtt ctagacactg aaatatacga ccaggaagcg gttgtaaaga 122760
tttctcatat tctgcaatca atcaaatttg cagagactat ggaagacctg cagggattca 122820
ttgcagacat taattggaaa ttagtttaaa aaaggtgttg acaccttagc acatagatgg 122880
taatattaag gtagttaaaa aatacaaatc agaaaaggat atgatgaaaa tgacaaacag 122940
aatacaagaa tttttaagca gacaagaaga aagcacagtg aaagacgtag cagaacatgg 123000
cgtagaaagt ggagcaattg gggaacttat ttacacatca gacgtagtga acttttttga 123060
tagatattac agtgatattg aaacagttgt tacggattac ttagaaggtg tcacaggtgg 123120
tcaatattat gacttattaa actatgagct aatgagtgac ttagaagact atgcaaatgt 123180
acaatttcaa tcagaagatt catatcttga acttcaattt gatttagcag aaaacattgc 123240
ttcagaatct acagactttg acgaagcgga cgaagacgaa caacaagaac taattatcga 123300
agctttagac tatgttgaaa tggatattca agacactgac aaagtggagt ttgttaattt 123360
agcagttgag attgtggctc aacaaatgca ggaagcataa gaacctgcag gaagcacaca 123420
gagacacaca gaggagctta accgcttctc taatacattt aatcaggaga tgttgaagat 123480
gaacacaaga cgggtaaata aagcgttaga cgaagcagtc agattattag acaagcaaat 123540
agcagacaca cagaagacaa tgcaggagct aaacaaacaa ctagagcaac aaataaaagc 123600
taagcaggag ctaatgacat taatggatgc tatgactggt gatgatgatt aatgaacatt 123660
agagaggctc ataacgttgt taggagtgca aagaacaaac ttctgcagga gcaggagcac 123720
atatcaaatc atgtcataga tgactacatc acagaggagc ttcacagacg cacacaggga 123780
agcgggacaa ttcagatgaa caataatact cctgcatata ccaatgacgc atatggtagc 123840
ttaaaagagc ttagagaagc ttatgacctc tctgcactat ctactggtga gattaaagaa 123900
ctaatcaaaa catttgttta aattctttta tcaaaacgct ttacaatctt ttagtttgta 123960
tgatataatg aacttaacaa attaaaagaa aaggaaatga tgaacatgaa taacttacaa 124020
gagagaaaag aagaattgaa aacattacta tttaacttag ctattgagaa gaacaaagca 124080
accgatgaga cactaagaag tgtcttagaa caatcccatc aagaagtgat gaaccaatta 124140
aataaagtta gaaaagaaat tgaaattaaa gtcgaagaaa aagaaagaga attttggaac 124200
gatatcgaat ttaatggatt agattaagag gagggcaaac gcccttcttt atttttattc 124260
tattatataa tttttttata ttatacgggg gcaggggtaa aatgccactc aatgggggtg 124320
ggtctatata cccctatggt ctacccaggt acttattttt tggggaaaat tatgaaaata 124380
aatatttaaa agtcaacaca taaaatatag aaagtaagtc aacatccctt ataataagtc 124440
aacaatttat agtacaaata taaagcctct aaatataaag tcaacatatc taaaataaga 124500
agagaggtat atcctctctt ctcttaacta tataagtacg cttctattat ttagttcctg 124560
ttctattcta tttaaatgct cccaaacctc aatccaattt actcttgaat catcataata 124620
aaggtggaaa tcttgagggt tttctaaata cgcttctagt tcatcatagt atagaacatc 124680
aaaagctgtg tcatcaagac ctatttgaat ctttagtata tctttatatc ctaattgttt 124740
attaccgcaa taagctgtat cttctaaccg cttctctagt ttattaaata gtgtttgtat 124800
accttgtagt tcattcataa tgtatgacct cctaattgat tatatactta gtataaagga 124860
taggtgttag aatgtcaacc tttatatata aaaaaagaga aagaatatta ttcttcctct 124920
aaggtattac taataacttc taattcatga atagtaatca tatccattct atcgaatcct 124980
cttgggtctc ctttaatgaa ctcttgttct cctctatgag ttatactttc tttatatcct 125040
tcttctttaa tacgtttaat taagttctcc ttatttgtgt atatctcatc ttccctgaaa 125100
tggaaattat cttcataggg ttcacaatta tcatgttcta cttgatatag tttcatatta 125160
gttatcctcc tattctctat agtaatcata tatttctaaa taaggtgaaa atggtgagtc 125220
acctctagta ttaataataa cttctccctc ttgattactt aactctataa gctcttctaa 125280
gctattaatt tctacacacc aacgttctat agtaaatgta ttaccttttt ggtctacacg 125340
ttctaattcc tttatgtagg caccttctat aggcttttta ttaattgtgc ttgttctatc 125400
tataaaaaat tccattactt ttcctcctta tacacttata cgcatgatta aataaaaatt 125460
ataaaactta ctgttatgat gttctatatt acaaaggtat aacattagtc tataataata 125520
ctctaaatca tgagtatgtt taaaagtttt ttcattaaac tcagattcca gtaggttaat 125580
aagtttttca tgagttaaaa catatgcacc ctcgtcacca aattcatcaa atttatcata 125640
atatatttct gcatctctta gtaagagttc cataaaatat cctggttttc taaaatcatc 125700
ttcaaaatta aatctttgat aatagttttt ttctaactga tttctatatt tcgaattgtt 125760
aataaaatgt tgtaatcctt tttgttctac ttttctttta cttaaagtta caccaattac 125820
ttcaaaatct aatcccatta cttttcctcc ttttcgtaag tccattcacc atattctgcg 125880
ttaaaatgag ctgtgtctgt tccctcatct tcatattcta cactatacca tgcatcttct 125940
tctgtttctg catctatata tcttatttct tctgtagtaa tagtacgttt taccttaaat 126000
ctctccattt gtttttcctc tcctctacct tcatagatat tacctataac acataattct 126060
aaggtatttg tatatgattt taaatagaaa tcactaagca aagtaatctt attaccttca 126120
taattttcta taaagaaaaa ccctttacct tttttaacga tacctgagtt tatatagtta 126180
ccattaatat cttgtatttc tacaatatct ccctcaaata tttctacact atttctatca 126240
ctaagacctg tgaattgcat aatttcaagg ttttctccta aataaccatc acaagcaaat 126300
agatgtgaat atactgtgta atctgcaaag tcaaacctag caatatcaaa cattctttgt 126360
gattcttcat cccatgctct aaatttaatc atctacttta ctctccttta tattctcttc 126420
taatatttgt tttaatgttt gacaatcttt ttggtctagg gtgtcccaac tctctagatt 126480
ctgtaattga tagtataatt catttacaat ttcatcgaag gcttctgctt tttgatagac 126540
ttcttgtaac tcttctaatt ctttttcatt atcaatacac cagtagttct cgttgtcagt 126600
tataatatct tgaattttat ttttatattc ataagccatt atttatccct cctatcttct 126660
atcctttgtt ttatctcttc tcgattacgg tggtgttctt tactcatttc tttacgttcc 126720
ttatttgtta atcttattct ataaataagg tagttaatat ataatgttcc ggctgaccat 126780
agtagtagga atgatattag gtaagtccat gagacactta tttctatcat tgtgagtcct 126840
ccttatattc tttataactt ttaataacaa tcttacagat acctctatta acagctaaga 126900
ataacataaa tgataataga gttataactg ctctaatgtc tccagtaaag ggtaataatt 126960
taaatagtaa aacactttct aaaacacttg tagctgtaat aattgtaaga tataagatag 127020
atagtaaata atcctttaat tttagtttaa cgaaaggttt tttattatct tgagttcttg 127080
ttataccata tagaattata aaccatgcaa caggtatgag ctgagttata aagtcattgt 127140
ttatgcctaa tacatataaa ccataaatga taccggcagg aataccaata atgaatgcta 127200
agaatacaga gaatataatt agcattaaag gaagagctac aagtaatcct aatccttgta 127260
ttgaatactc tagtgtattc tttcctaagg ctttaaagaa tgttttattc atcttctacc 127320
tccttgtaat atacagtatc tatatgagta atattatctt taaaccatag agacttatcc 127380
cctttgttag attctaaagt tttagcacca ttaaaaacaa gaccctcaat aaaagaattt 127440
aaattagttt tagtatcttt ttgttgtacg ataatagaag accctgatac atcacaaatt 127500
cttataaaat taatatcttt ttttatttct ttttctactt tattattttt aaatatcatt 127560
ataattcctc ctctatataa tcaactgttt taatatactc actatttttt agtacctttt 127620
tcacattttc actaataaat ttttcttgct ctatttcatc tattttttcc tgtattctaa 127680
gatacagaat ttcaggaaca caggcagggt tttgtaattc ttcttctgta actgagtttg 127740
taaaacttgc cattccatca ttagctagaa taagaccatc tgtaattcta gttaatttat 127800
ctccattagg tttataatat ataacttcgt aaacctcttc atctttaaat aactcttcac 127860
gaggtattct tctagaggag aagctataac catttttaaa ggtgataatt gtattttgag 127920
tttctcttaa aaatactctt aaagtatttt caaaaatatc ccattttttc ttttcttcat 127980
ctgttatagt tatattttcc ttgctttttt taaacatcgt tattattcct cctcttcttc 128040
tatagaatta ctttccgtaa tagttacttc tagcatacta ttgtaatact cattcttttg 128100
attaatatta tagttatcat tatattcatt gaagtctaca taaatgtatt catttgttcc 128160
attttcataa ataatatcta tagctgtaat atctgagtac gctgtaatca tttcataagc 128220
atttgtatta tcagggtaag caaaaccaac ttgaggtatt tctttaggct tattaatgag 128280
aataccaaag taagtacaat gacgtgttct atttatgtgt gaagttcctt tatacgtacc 128340
atagtaattt attccttctg taacaccttc tatatggaac ctgtttacat ctttaggttc 128400
taaccttact acatcacaat tttctaatac taagtctata tattttatat tcattttaat 128460
tctccttttt tatttgtatt tgttgtatac acaatgtact cgaacgtctt ccattacttt 128520
acctaataga ttctgacctt tccagttact ctcatctaat attttagggt cactttcttt 128580
aagacctact ccccatattt tatcataagg tgatgcctct acgaaatctt tacgtaaatc 128640
tgtatcgagt atttcccgtt ttaagtgtgt agtcataaat ttatctttaa ccacttctac 128700
cataatgtca tatcttacct tattccattg ctcttcatta aaattacgaa ctttacgacc 128760
tagactttta gcatggttcg gattcttagc atttaatatt tctcctgcta tttgccagtc 128820
tttaaaatat tgcgctttgt gccacataaa agcttgttct gagttattaa atgttctccc 128880
tttatgttta aatgttattg ggtaaaagtt agaataaata tcttccttac cccaaaacat 128940
aatgtatctg cttgtttctt tcataatatc tcccctttaa ttccataatg atggtaacac 129000
aattttgaaa ttatctaata ttttattttg tacttgttca agctcatcat atttatccat 129060
atcaaaatca tccatttctt catgataata ttgtattaag cttaaaatat gttttatcat 129120
atctatttgt gttctttctt caccatctac atctacaaaa gtattccatt ccatatctat 129180
acaagaacgt tcactacttt ctataaaggc atttaaatcg gcatataatt gaacaaaaaa 129240
agacatatca tagttccaat acttaggttc atttcttcct aattttttat tcattttttt 129300
atactttcta tttctcttta acccaaaaac ttctttttca aaatcattta attttaaacc 129360
tttaaaatat tttttcttca tatctaatcc tccaatttaa taagtggtaa atctatatct 129420
ctaaatacag aacctacgtc acatagcagt atatcattat gttcttctac ttcaccacta 129480
ctagtaggtg tatgaccaca tacatatata aatccatctt ttctaggttg gaagtctcta 129540
gaccatatta actggtctac tgtttgctct tctataggtt tccaactaac tccccctgaa 129600
tgggaaaata tatacttacc ttctttataa taccttctac aattaaccat aaatatttta 129660
aattttctat aatcttcaga ttctttaagt ttctttagtt cacttttaat aaaatcataa 129720
tgatttctta aattatcttc tacactttta tattttaaag ttacagtact aacaccgtaa 129780
gagttaagtg tttctataca ataccttgat aaccattcaa tatcatagat acttaaccgg 129840
tctacgtttt ccataatatt ataaaactca tcatcgtgat ttcctaataa agctactaca 129900
ttatcatcat ttgatagtaa atcaaacatg tagttaacaa cgtcttttga ccttttacct 129960
ctatctacat aatctcctaa aaatacaata gtatcctcgg gtcttctttt ttcatttatc 130020
ttatccataa ttttcagtaa tttattgtat tcaccgtgaa tatcaggaac cacgtatata 130080
gccatttaat ctcctcctta ttgtatataa ctatcttacc atacttattt ataaaagtca 130140
ataaaaaaac acctattaat gaaaataggt gtccgacaga gctcccgtac ttagattacg 130200
gttaataata ttttacgaca attatatgag accctctatc gttgaaacgc tcgtcactgc 130260
gttagatacg gaatggaggg atactaccat ccggagtcta cggtcagata caaagcctct 130320
gccgggcaac atacggtatc tctcgtacat caggttgact agacctttag agattttcac 130380
tccttctctt ataaccagta acttaagaga aataggtttt acttagtaga tatgaaacaa 130440
taaatctaca tataatatta aatcatagtc aagtgattgc acatatgtct aatacctata 130500
agttttttgc tagcctggta tatggactct gtaggattcg aacctacagt caaaccgtta 130560
tgagcggttg gctttacctt taagctaaga gtcctagaaa tatcctgaga gaggactcga 130620
acctcaacga ctaggtagct acaactagcc agtgccatta ctcaggattg ctagtaacgc 130680
taaatagagt cataacgtta ccgtagacct tttctactct tggtagatag gtaaaatata 130740
atgatttcaa agtacctata tagtcaggct cttactctca ttataaggtt aaaaaggtta 130800
actgtgttta gcattatata agaggcttta gttaactact atactaatag tatatcataa 130860
atagtactta gtgtcaagat aatttatcaa ttgaatccat aatttttgat gtacttctta 130920
tatccgcttc tttactgtgt ttaagaagat attttaattt cattagaaaa gaattctttt 130980
ccttttctat agtatctttc ttgttactat attctgaata catcataaat tctataaata 131040
tactatttct gtcagatgaa aacatatcta tagaaaatgg acaatcaaaa cttatgtcat 131100
ctttattaat actaaaacat tcagtaacat ttaaatcatt tatttcatat acctcgaaat 131160
atccatcaac tcttttaagt tctatagcac tattatatct ataataacgt tgttcctcta 131220
ttaacttatc ttttgttaga taaggatatt catttataaa tataggatta cttgttccat 131280
agttattttt aatatattca gcatcttcta aggaatcagt ataacctaaa acttcgtaac 131340
ttgttgtata cacagtatct tcttcccaca agtcatagtc catttcctct atttcttcct 131400
ctagtatata aatttttttc atatattact cccaaacacc aataagattt ttaagtttag 131460
ctataacctc ttcttctgtt tgataagaaa atactcctgt aatgtgttca tagttaccta 131520
caatttcata atcctgcgta ccgtgtctgt ctactagata cgagttaccc ataacattta 131580
aactatcttc tgaataactg aaatttatat tatagtctac taaaaaatta ataatttttt 131640
tcatttacat aacctctcct atcggatatt gtcctaacat tcttgttcca ttttcattat 131700
aaaaagtata ttctactaca ataatattca tcatatctac atatatagct tctatataag 131760
gtttaatatt ttcttcttct tgtatatgct tacctataat atcatataat aattcagagt 131820
gtattctttt atctctcatt gtagacctcc gtaagaaatg atacagtctt atcttttaaa 131880
gatttttcta ctagttccat agcatcttta taatgtttta tgctagattc attagattta 131940
agtttatctt ttacttcttg gattaaaggt tctactttat taaccaaatc ttttttcttt 132000
tcaatactta cattacttct cttattatct aatacttctt ttggcatata cttaactttt 132060
gcaaagtctt tatagctaac atttaagtta tctaaatcat ctaataaatc attataatat 132120
tctaaatgat tatagaatgt gtaaaactta acaaggtctt taccagttaa ttcttctttt 132180
tttaatatat tattgatatt accaataaca gagtatgcta taggcttaaa attagctcta 132240
acataagtta aaaatataaa atcatcataa aacaagtcta aaacagtttt attgaatcta 132300
gtgtttttag cttgctctaa ttgagcacat aaattaagaa cattatcaaa tccactcttt 132360
aataccaaag aaataaatct ctccactgca tagtatcgag atacttctgt atgtttactt 132420
gccttttcac tatttctaaa tatagtatct gataaaggtt gaactactaa actcatgtaa 132480
tctttatctg aatactcatc tgatgttcct tgataggtac ttccaaattc tattgttgat 132540
aataagaaac ttttttctaa gttcattata acatcctcct tttacttgtt atttaaataa 132600
taacatatgt tgatagtaat gtcaaacatt aaatatcttc tgttgtgtca acttcatctt 132660
gtttatattt aaagtgttca taaactttaa atagaatagc ccctagtgtt attaattcta 132720
aaatatattt cataacaatc ctccttaata accgtgttta gttacccatc ctgctaaagc 132780
atccatagcc atatcatatt cttcttcatt tttaattctt ataattttct ctatttcttc 132840
ttttgcttgt ttagaattca taaaatcaat atctactgta tctaaatttg tataatcaat 132900
attttctttt ataaactctt tttgcggtag ggttatagaa ttaactcgta cattttcgtg 132960
atttaaaaat tgatagaagt ccatactatt caccttcttt taaacagtct gccatatctt 133020
ttaaagtatt aagtacatat ttcaaatctc tataataact atcagaaaaa ctaataacag 133080
catatggtgt catatcacta tagtgtgcac aatcaaaacc taatacccta tagtcacctt 133140
catgttcatc gtatgttata cctccatgag aaaagttttc tatagcatta aacttctctt 133200
cagttatacc agtaggaaca ttaatataac cgttcaaatg tcccatttgg gggtgacgct 133260
taaccgttaa ttttatacct ttataatcta tatttaaagt taaatcctct cctaatatat 133320
tatcctcttt ggctatagtt ttcataacat gttcaggtgc tttttcaaac atagtattta 133380
tacctccttt tatttataat tctactatac actatttttt atgttttgtc aacttttatt 133440
tcttactcca ccttcaacat aaattcctaa agacttaact aaatttttga tggcagtagc 133500
acttaaatca tacttagaac ctatactttt atatccctca ccctgcaggt atcttctttt 133560
tacatcctca gtatctacct tattataagt tatattaaac gttaattgat tctttatttt 133620
tctttcgtta actaataaaa aaggtaattt tgtttttaaa tcacttataa gtgattttat 133680
attagttgaa aagtaattaa tctctataag aactatatta ttatttttac aaaattcttt 133740
ttttatttta tcattttcaa taatagattg gtggtcaaat ctacctgagt aggtatcttc 133800
tatatgctgt ctcccttgca cttcaataca atattcaatg tcattataca tgaaataaaa 133860
atcaaatctt aaattaaatc ctttattact ttttagattc ataaatgttt tttcagttat 133920
atagtctaca ctattatcaa ttaatatagt ttcaactgct ttttcccctt tagaccttct 133980
atcggagcac atacgacatc ctaaaccata attatataaa tcagttagct tcatcttttt 134040
tgtatcagaa catctaggac aggttacctt aacaacctta ttagattgta agggtaaatc 134100
ttttacctct tcccaattac tatggaatag ctccttcata ttttcattat cagacagtct 134160
tttctcgaag aggtttttaa cccttacttc ttttaaattc ttaccacata tatttatagt 134220
tcttttatta aaatcgttat aaagttctaa ataatgtgtt ttattaaaat aatactttat 134280
tacattaata ttgtatactt cattattata aactatttta atatttttcc ctggtaattc 134340
attccatttt aagttaccat tatcatatat tgatgatagg tctacagaat ttatttctct 134400
acctctgtca cagtagtata caccttctat attatatctt tttatagtca taccgtacac 134460
tctcctgtta tcttaaataa tctttaagct gttcttcttt atagaatctt ctattagtag 134520
gtgttctata cgccactaat ataccctctc tatcccatct ttgtaatgtt ttaacagtaa 134580
ctcctaataa cttagctact tcttttggtt taagtcccat atttgattac ctcctgtttt 134640
tttatctata cataatataa cacaaataaa cacattttaa cacctttttt tttaaaataa 134700
aaaaataggc atgaataaac atgcctaata aagtattact tttggtagta tttccatttg 134760
aagtaaccat ttttctgtga gaactcatag tgaaaaccat cgtagtcaaa ttcaatatta 134820
tagtctccat cttgaagtgg ttttgaattt agtacaggac tattactctt tgccaattct 134880
gctagaaact catgatttac tttttccata gggtttattc ctcctaatta ttcttacagt 134940
actaatatat cacaggtctt tttctaggtc gtttttaaac ttctcctcgt aagagctagc 135000
ataagtaacc tcatatccta ttatcttagt ataatctatg caaagtaatt tataattgga 135060
ttttacttta atatcttctg attgttctat tttgttgata atttcattta attcatctga 135120
agagtagtgt tcattatcaa cttttattgt ttttccctgg gtatagatat caatttcttg 135180
tatcatcatt tcatcctttt gattattcat tatttgatta taagtttcta aatcatcaat 135240
attatctgta tctgaacctt ttactaacca ttctcctctc tttttaagga ggtcatcaaa 135300
cttctcatgc tctttaatta tcttctctac ttcactcggt attagaacag ctctagcgta 135360
atttatatgc cacatagaca tattatcaat aagataatta accattctta taagttcctt 135420
ctcatttgcc atataccaac ctccttatat ctaatactaa tataagagaa aagcagactt 135480
attaaaagtc tgcttctgta cctaattcta atcttctatt tttcatatga ggaatcgttt 135540
ttctatctcc tgttaataga gataattctc tagctttttc tttagataat gttaatagtc 135600
cattataatt atctacttta ctattatatt gtcttactaa gtactctagt tcatcttcta 135660
tatctgatag ctctcctgat ttaactccaa gtaactttct atacatatca taatcttcag 135720
aaagactttc tactttattt ttagatacag aatcataaac tgcttgtaaa ttaccttctt 135780
caataagttt aaagttatgt tcacctatga ttaattcttt ctcagaagaa tcaagtgtca 135840
ctaacccact tgtattacct gtaaagtcac ctttataatc tacaacaata ccttcagtta 135900
ctttgtcacc taattcaata gtcccatctt cattttcttt aaatttatga gcatcatata 135960
cttctacttt gtcacctaat ctcaaatctt gagttaagtt atgtttacca ataattctat 136020
ccattactca atctctcctt tattaatagg gtcttgtgtt aagaacattt ctagattctc 136080
ttttgtaata ggtaaccaaa aatatttact ttccggaatt gtaactgtat agaaatcctc 136140
atctttgtta actttaatat taacatctgt aaactcatct tgcattaacc aatgagttac 136200
agttaagtta tatgacccat cactaacata ccctaaatca atatcatgtt taaaagctaa 136260
atcttctaag tgctctaata aatcattctt ttcattttgt tcttcttctg tattattttt 136320
gattggatta attaactctg tacaaacgat atcatacaac tcaccatctg taacttcata 136380
attcttttct attaatacat cttgtatttt attgattgaa tttgtaacta ctgctccata 136440
ttcttcttct gtaaaattac atttatctaa atcaacatct gtaattaatt ctgcaatcca 136500
tttatttaaa attgataccg ccattgttct agaaataata ctatcatata ccatatttat 136560
ttaatctcct tgtttaggtg aatgtggtct tctaatgaaa aatcaaaagg cgctacacca 136620
tttcttttat tgtttgtttc ttttttaagt ataacataag ttagtgaaaa agtcaagata 136680
gttactacaa ccattaataa aagtttaatc agattcttca taattactct aactccttaa 136740
gtttattttt tactttttct ttatcatact tataatcttt ttctgagttt tcattttttt 136800
ctttctcttc ttcattaagt tctctgtatt gagcttcttc tacctcttgt tccttattat 136860
ctttgcctgc gtctgctttt tgaatttcta catttttact actaccgcca ctcacctttt 136920
ttctaaaaag aaaccaaagt attaataaaa tgatgagtaa aataataatg cttaatacaa 136980
ccgcccaaat attattagcc attacaacct acctccaaat agttttttta cagctcttaa 137040
gttttctgct gactcattgt ttatatgaat acctgtactt gaatcgaaaa taacagcatt 137100
atcaagtaag tgttttttaa gttcattttc ataacttcct ttacctacta cactaccata 137160
accatcgtgt gttaaatcag tcatatcaga ttcaacttct aatactctaa acgatactct 137220
acgtaaaaat gatgggttta ctaagtaaaa ggatgattta aaaacattta atctttgata 137280
agaatgtttt atattaacaa caaacccagt aagtttatca ttataacttg agtttgatag 137340
cttacctaaa tataaattta tactataccc ttttgtttct aaagtttgta tagcactaag 137400
cagtatagct cctctataag caagattctc agggtcttcc atccaactta tactagaatt 137460
atagaataca tcaataactt tcttctctgc tttaactctc tgttgagaca tcatagaatt 137520
aggtaaacct tttatagcgt taggtacatg aggttgataa ccttcaggag ccacaactgg 137580
ttttcttttt acagatttat ccattctgaa taatgcatct gtcatctttt taagcttaac 137640
aaccatatca taagactctc tatctccttt aaccattaag ttataggctt cattaaagct 137700
atgagtgcct gtgaagtcgt agctacctgt atctgatgaa ttgtctctac ctgaaactct 137760
attctttttt aaagcagaaa agaaatcagg tagaccatca tatttaatta catttaattc 137820
tgagttatct attaatcgtc tacccattgt tttttcctcc tattctaatc ctagtttatc 137880
catgatagtg tcaaagtcca ttgaatcact agatgaactt tgagtttttc ttggttcttg 137940
tttaggttct tgtttgatac ctaaaagatt ttttgttgct tctgtatatc tgttatcttt 138000
aggtaaagaa ctaataaatt gattaatttc atctttaggt acagacttga agatgatgct 138060
ttctacaaca aactcatcgt ccattactcc atctaattta cttccattaa taattgcacg 138120
cattgaaaag acataaggta atcctttttc atcgttctca tatcttaatt tttgtacaaa 138180
gtttactaaa tcctcattac ttgatagttg gtgttctacc ttattatcat aatcaaattc 138240
aacttgagca aaacggtcta atgtagctcc atccagttgc tgtcttccca cataaatatg 138300
gtctgctcca gttcccatag tattacctgc tgatactact ctaaagtctt catgtgctgt 138360
cacacgacca atagggaagt caaagtattt atttgcaata gctgagttaa gaattaataa 138420
tacttcaggg atagatgcat ccatctcatc taggaagaat aatcctccat ttgtaaatgc 138480
tttataaaac tgagtttcat gaaacttacc atttgcatca ataaatcctg ttaatttaaa 138540
ttcttgagta attgcattac tgaaatagaa atctaagtct agagcttctg ctacttgctc 138600
taatacatgg ttctttcctg aacctgctcc accttttaaa aacactggaa tattttgatt 138660
aactagtttt aatatatctt gatatctata atggaagatt cctgagatat ctttaattgt 138720
tttaccttct tgttgtaatt caatcttaac tggtaaatta ttaagttgct cctctacgta 138780
ttcttcaatt tgttttttaa catcagtaat aattatttct ctactctcag ttcctgcttt 138840
ctctacaatt gcatccacaa ttgcttgttc ataagggtta gagtttttct ctcctagttt 138900
atctgctaag tctttcgttg tctgcatttg ttgttctacc aatctctcta atctttcaat 138960
agtatcttgc tttgccatat ttatcattct cctttgattt gttatacatt tattataata 139020
caagtatttt catttgtcaa caactttcta aaactttttt agttgttaat aaaaaaatta 139080
ccttatacct ataacttaac atagggtaag gtaattgtca acacttttat ctaaaaatac 139140
attaatttaa aaaagtcatc aatgtcttca gttccatgtg tatccatatt atacataaac 139200
atacaattat atgtatgttt attcactatt tctagcatat tgtgcataga agttgcatta 139260
ttgaattctt ctaaatcaat agttatcgta agttcttgac cttcgtaaag tatgtttgct 139320
atatagtatg ttttaacacc ttccattgtt ccgtgggaag tttcattatg attaagaact 139380
tctataccta atgaaggtaa ataatctgaa aaatagtatt tgcagaaata tataaaattg 139440
tctgttcttt tagacacgag tactatcccc atattttata tttctttcta atcttacata 139500
atatgtttta atcttttgaa cttctttgtc tactgcatct tttcttccta atcttgtagt 139560
atattttaca atattaaata tcatagaatc aacaaaacca tcataagaaa agtgttcttc 139620
tagaaaagaa ataacatcct tactaccttt atagtgctca ggtaaatgtg catctacttg 139680
tatattatag taatcttcta aaagccctat actttcacca agactagata aagcataacc 139740
taaatcatta gagtcattag accattcttt agatactgat aaagcatctt ctataattgt 139800
tatttttaat ttatctaagt aatcttctac ttgagcttgt gttttcataa attcttttgc 139860
attcatttaa taccctccta aattgtataa aaaaaacacc ctgcttggat acaagcaagg 139920
tgaaaaagga aagatattat ggaagtgtac tatctaagta cacctcataa tataacagtt 139980
ttccttgcta gttattactt attttttaag gtcttcttct ttaacaaaca ctccgttaat 140040
aagcttacct ttcctgtctt ttatctcatc ataagccata tcaatacact cttcaatatc 140100
tatatctaat tgtaaacata gtactgttaa tactacaaaa atatctccta cactatctcg 140160
tgttacatgg tcattacttt tagcaatacc tgaagctaat tctcctgctt cttctaataa 140220
ctttaacatt tgaccttcag gtttacctgt ttgtaaattt ctatcttttg cccattgctt 140280
aataagttct actttttcca ttattctata tctcctttaa tttctgtatc ttttataatt 140340
agattatcag aatcacttat tacagttaag ttatcttcga ctaattcatg taggttatta 140400
gtaatatctt cttcatacct ataacctaca cgaacataag ctttcaccct gacatctata 140460
ttaacataat cttcttggaa tttttccatt tctaacttcc tttattatac catattgtta 140520
tacctttgtc aattaatctg agtagtttcc tttggcaagt tgatactttt tgtgtaattc 140580
ttcatataat tctctcatac cttcgtagtt tctcatatca tcttccaaga aactaagata 140640
atctaataat aatttagttt cttctacttc taaagttata actggtttga ccatttatgc 140700
aacctcctta aattcttctt tatttatttt cttaatatct ttttctaatg cttcttttag 140760
ttcattaggt aatttatatg catcaattga ttgttgctgt cctaacacat aaccattatc 140820
tgtaatacgt atttcaactg taaaccatga attatctaaa tcttcttcta atcttgctaa 140880
taatattaaa cagctattct ttagaattct attagcatat cctccaacac aatgagataa 140940
cattctacct tcatctttta atttacttac agtatctgca ggaaggaatt ttacttttct 141000
accatctttt aatttataag ttttatcaat tattttttct aacttattat catacttagc 141060
tttaagttct gcatcatcta attgttgttg aatggattgt ttttcatctg taactatatc 141120
atgctctaac ttcagtgaaa aaggcgttaa gttaacactc tctaatgttc tatacccttc 141180
tcggattagt attgataaat cttgtaaata gtcaaggtaa tatctatcta gtgcatatcc 141240
tgttatacgt tgtctgtctt gagcatctac atctaaatag tgcgtcatct ttttgtagtt 141300
agcaaaagat atagataata tttgatttac aataggttta acttttaaag catcagtaac 141360
atctcttgaa tctcgaacca ttaaaaaagt atcatcaaat aattggtgta aattaacctc 141420
attgtgtaaa tgattatagt acttatatag agtattagca aatcttaagt aattaccttg 141480
ctcaaattta tttaaagtta gtaatttttt ataagtctgt tttgtaagat tgaaagcttc 141540
atgaactttc catttaggat ttttaggtat atgaaatagt aatgcatttc tttcaaataa 141600
tccaaattcc tctaagttat ttattttgtc aatattttta acaatatctg ttaaagttgt 141660
taagtaatta gaagttgaat tttctcctat aaaaatccta tatttgtctc ctctataatt 141720
tatatgacca taaacatcta tattatccgg acaccaacta gaaaaatcaa aattatggtg 141780
ttctaatgtt tgttctatta tctttattat aacccctcta tttaagttag gttgtgagta 141840
attttttaaa ataacattta ataaaacaga taatgtcaat tcatttttat attcactttt 141900
acttatatca tctttataca aatttaaagt tagttcttta ttaacaaggc tatctgttaa 141960
gaaaacttta acctcccctg ttttaacatc aaatgaactt ttattttcta aaacccattt 142020
attacccata ttatgtttat ctctgatatg tctaacttta agaccgaaag atgaattatt 142080
ctcagtacct ggatgcatgt accaagcact actatacaat gaatctgata tttccttata 142140
atacttactt gagccttttt ctgtatcttc attcatataa gaagtaatag atgattttat 142200
taaaccgtac ttaccttggt ctagaatatc cataatatca tcatttaaac tctctactac 142260
ttccttatac tcatctaatt gtctagcttc atacccccat aatcgggttt cattttctaa 142320
ttctttaatt ttttcttcta cataaccttt agattttatt tgtcttctgc tcttattacc 142380
atataaagga aattcttttc tttcttctct actggattca atatattctt tgtaatttct 142440
tcctttattt tctccaatta caccttcaac taatttttca actgtttcat aagggttacc 142500
tgtaaagttt gttacttctt tattaccaca tagtgctaag aataaatgta tttctgtagc 142560
agtatcaaaa ctaaatatat tatgaatatc tctaaataat tccttagagc ctaagttaat 142620
tatattattt ttcttcttct taaggaatac atcttcttct cctatgtaga tacatccttt 142680
attaacttta ggtaaattaa taatttcttg ttctgttaat cctttttgtt tatatgttat 142740
tgccatttaa aatcactcct tatttgttat gtactaatca tatcatagta agtcatattt 142800
gtcaacaaaa aaaaagaaga acttttt 142827
Claims (9)
- 황색포도상구균(Staphylococcus aureus), 표피포도상구균(Staphylococcus epidermidis) 및 메티실린 내성 포도상구균(methicillin-resistant Staphylococcus aureus)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SA3(기탁번호 KFCC11713P).
- 제1항에 있어서, 상기 박테리오파지 SA3는 pH3 내지 pH11의 범위에서 안정한 것을 특징으로 하는 박테리오파지 SA3.
- 제1항에 있어서, 상기 박테리오파지 SA3는 40℃ 내지 70℃의 범위에서 안정한 것을 특징으로 하는 박테리오파지 SA3.
- 제1항의 박테리오파지 SA3을 포함하는, 항생용 조성물.
- 제1항의 박테리오파지 SA3을 포함하는, 사료 첨가용 조성물.
- 제5항의 사료 첨가용 조성물을 포함하는, 사료.
- 제1항의 박테리오파지 SA3을 포함하는, 소독제.
- 제1항의 박테리오파지 SA3을 포함하는, 세척제.
- 제1항의 박테리오파지 SA3을 인간을 제외한 개체에 투여하는 단계를 포함하는, 포도상구균에 의한 감염성 질병의 예방 또는 치료 방법.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023140723A1 (ko) * | 2022-01-21 | 2023-07-27 | 서울여자대학교 산학협력단 | 스타필로코커스균 특이 박테리오파지 kmsp1 및 이를 포함하는 항균 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR102097127B1 (ko) * | 2019-04-02 | 2020-04-07 | 서울대학교산학협력단 | 황색포도상구균 유래 바이오필름 제거에 효과적인 박테리오파지 CSA13 및 그 유래의 엔도라이신 LysCSA13 |
| KR102358905B1 (ko) * | 2020-05-20 | 2022-02-04 | 서울대학교산학협력단 | 황색포도상구균 유래 점보박테리오파지 PALS2 및 그 유래의 엔도라이신 LysPALS21과 LysPALS22 |
| KR102432624B1 (ko) * | 2020-09-29 | 2022-08-16 | 주식회사 옵티팜 | 신규한 스타필로코커스균 특이 박테리오파지 opt-sc01 및 이를 포함하는 항균 조성물 |
| CN114410591B (zh) * | 2021-12-02 | 2023-08-15 | 菲吉乐科(南京)生物科技有限公司 | 一种耐酸耐高温的金黄色葡萄球菌噬菌体及其组合物、试剂盒及其应用 |
| KR102418861B1 (ko) * | 2021-12-15 | 2022-07-08 | 주식회사 마이크로진 | 포도상구균에 대한 사멸능을 갖는 박테리오파지 |
| CN115125216B (zh) * | 2022-06-27 | 2024-03-05 | 广东省人民医院 | 一种耐甲氧西林金黄色葡萄球菌的噬菌体及其应用 |
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