KR20180074578A - 신규한 장알균 특이 박테리오파지 ef1 및 이를 포함하는 항균 조성물 - Google Patents
신규한 장알균 특이 박테리오파지 ef1 및 이를 포함하는 항균 조성물 Download PDFInfo
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Abstract
본 발명은 장알균, 특히, 엔테로코커스 패칼리스(Enterococcus faecalis)에 특이적인 사멸능을 갖는 신규 박테리오파지 EF1, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 장알균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 EF1을 이용한 장알균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 장알균, 특히, 엔테로코커스 패칼리스에 대한 특이성이 매우 높고, 상기 박테리오파지 EF1은 상기 장알균에 감염하여 장알균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 EF1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EF1은 장알균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
Description
본 발명은 장알균, 특히, 엔테로코커스 패칼리스(Enterococcus faecalis)에 특이적인 사멸능을 갖는 신규 박테리오파지 EF1, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 장알균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
일반적으로 엔테로코커스(Enterococcus)속 균주는 장알균이라고 부르며 그람양성이다. 대표종은 엔테로코커스 패칼리스(Enterococcus faecalis)와 엔테로코커스 패시움(Enterococcus faecium)이 있다. 상기 균주는 사람이나 온혈 동물의 장관 내에서 상재하며 분변을 통해 배출된다. 일반적으로 병원성은 비교적 낮지만 드물게 아급성 심내막염이나 요로감염의 원인이 된다거나, 치주감염 장관계 감염, 창상감염 및 패혈증 등 원내감염의 주요 원인균으로 알려져 있다. 엔테로코커스 패칼리스 감염의 특징 중 하나는 치아 뿌리, 요도뇨관, 요도 스텐트, 심장 판막 등에 바이오필름을 형성한다는 것이다. 바이오필름은 미생물에 의해 생성된 막 형태의 구조물로, 바이오필름으로 증식하는 미생물은 동일 미생물의 플랑크톤 형태보다 항생제와 숙주방어에 대한 저항성이 높다. 이와 같은 바이오필름 감염을 해소하는데 많은 어려움이 있으며, 만성 또는 재발성 감염이 흔히 일어난다. 또한 엔테로코커스 속 균주는 드물게는 감염형 식중독을 일으키기도 하는데 식품이나 공공용수 등의 오염지표로서 사용되는 세균이다. 특히 반코마이신에 내성을 나타내는 장알균은 다른 병원성 세균에 비해 상대적으로 연구가 많이 되지 않고, 병원성에 대한 중요도가 낮았으나 최근 다양한 장관계, 피부, 호흡기 감염에 있어 원인세균 또는 복합 감염의 원인으로 주목받고 있다. 이와 관련하여, 엔테로코커스 패칼리스는 반코마이신에 강력한 항생제 내성기전을 가지는 것으로 알려졌으며, 반코마이신 내성 장알균(VRE)은 1986년 처음 보고되었는데, 병원감염의 중요한 원인균으로서 치료가 어려워 감염 관리의 주요 대상 세균이다. 전에 반코마이신을 투여 받은 적이 있거나 다른 항생제라도 오랫동안 사용한 사람은 이 균에 감염될 수 있다. 또한, 반코마이신 내성 유전자가 황색포도상구균 같은 다른 그람 양성 균으로 전이될 가능성 때문에 더욱 위험하며, 특히 내성 유전자인 vanA가 이동성 전이인자에 의해 빠르게 전이됨으로써 퍼져나가는 것으로 알려졌다. 최근에는 vanB, vanD, vanE, vanG 같은 많은 내성 유전자가 발견되었으며 이 중 vanB는 vanA처럼 플라스미드에 존재하여 빠르게 전이될 수 있는 내성 유전자다. 이러한 항생제에 대한 내성은 엔테로코커스 패칼리스의 바이오필름 형성능으로 인하여 더욱 강화되고 이에 따라 균의 제거가 어려워지면서 효과적인 치료제 개발이 요구되고 있다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
그러나 현재까지 장알균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이며, 장알균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
이에 본 발명자들은 장알균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 장알균, 특히, 엔테로코커스 패칼리스를 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 장알균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EF1을 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지 EF1을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 EF1을 개체에 투여하는 단계를 포함하는, 장알균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 장알균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EF1을 제공한다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 EF1을 개체에 투여하는 단계를 포함하는, 장알균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 EF1을 이용한 장알균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 장알균, 특히, 엔테로코커스 패칼리스에 대한 특이성이 매우 높고, 상기 박테리오파지 EF1은 상기 장알균에 감염하여 장알균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 EF1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EF1은 장알균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 박테리오파지 EF1의 엔테로코커스 패칼리스에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 EF1의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 EF1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 EF1의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 EF1의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 EF1의 열 안정성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 EF1의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 EF1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 EF1의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 EF1의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 EF1의 열 안정성을 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 장알균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EF1을 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 해당 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명에서, 상기 장알균은 바람직하게는 엔테로코커스 패칼리스(Enterococcus faecalis)이다.
상기 엔테로코커스 패칼리스는 항생제에 내성을 갖는 다제내성균일 수 있으며, 예를 들어, 반코마이신, 아미노글리코사이드, 아즈트레오남, 세팔로스포린, 옥사실린, 설파메타졸 등 널리 사용되는 항생제에 대해 내성을 갖는다.
본 발명의 박테리오파지 EF1은 정이십면체의 머리를 가지며 긴 꼬리가 있는 사이포비리대(Siphoviridae)에 속한다. 보다 구체적으로 박테리오파지 EF1은 머리 부분이 약 100 nm의 크기이며 꼬리의 길이는 약 400-500 nm이다.
상기 박테리오파지 EF1의 단백질 패턴 분석 결과 55 kDa, 48 kDa, 40 kDa, 35 kDa, 31 kDa, 그리고 24 kDa 크기의 단백질을 포함함을 확인하였으며, 박테리오파지 EF1은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.
본 발명의 박테리오파지 EF1은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 EF1은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 장알균 특이적 용균활성, 내산성, 내열성은 본 발명의 박테리오파지 EF1을 장알균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 EF1을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 EF1은 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 이를 박테리오파지 EF1로 명명하고 2016년 9월 30일에 한국미생물보존센터에 수탁번호 KFCC11692P로 기탁하였다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 장알균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명의 박테리오파지 EF1은 장알균에 특이적인 사멸능을 가지므로, 장알균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. 보다 구체적으로, 본 발명의 박테리오파지 EF1은 엔테로코커스 패칼리스에 대한 특이적인 사멸능을 가지므로, 상기 균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있으나, 이에 제한되는 것은 아니다.
본 발명에서, 장알균에 의한 감염성 질병은 요로감염, 창상감염, 균혈증, 심내막염, 수막염, 혈류감염, 장관계감염, 치주염, 치은염, 농양, 균혈증 및 패혈증 등을 포함하나, 이에 제한되는 것은 아니며, 장알균에 의한 2차 감염을 포함한다.
본 발명의 약학적 조성물은 1 × 103 내지 1 × 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 × 106 내지 1 × 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU (plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.
본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 EF1을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 EF1은 기존 항생제에 비하여 장알균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 사료 첨가용 조성물을 제공한다.
축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 EF1을 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 EF1을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 EF1을 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 EF1 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 장알균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 소독제를 제공한다.
장알균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 EF1을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EF1을 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 EF1은 장알균에 특이적 사멸능을 가지므로, 장알균에 노출되었거나 노출될 가능성이 있는 개체의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EF1을 개체에 투여하는 단계를 포함하는, 장알균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 EF1은 장알균에 특이적인 사멸능을 가지므로, 장알균에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있다. 보다 구체적으로, 본 발명의 박테리오파지 EF1은 엔테로코커스 패칼리스에 대한 특이적인 사멸능을 가지므로, 상기 균에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있다.
본 발명에서, 장알균에 의한 감염성 질병은 요로감염, 창상감염, 균혈증, 심내막염, 수막염, 혈류감염, 장관계감염, 치주염, 치은염, 농양, 균혈증 및 패혈증 등을 포함하나, 이에 제한되는 것은 아니며, 장알균에 의한 2차 감염을 포함한다.
본 발명에서, 용어 "개체"는 장알균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 EF1 또는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 EF1 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 EF1의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예
1:
신규한
박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 분리
장알균에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장, 도계장 및 농장 부근의 하수로부터 채취하였으며, 박테리오파지 분리에 사용된 반코마이신 내성 엔테로코커스 패칼리스는 아시아태평양감염재단으로부터 분양받은 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 엔테로코커스 패칼리스와 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다.
전배양된 엔테로코커스 패칼리스 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 BHI(Brain Heart Infusion) 탑 아가(top agar)((Brain infusion solids 12.5 g, Beef heart infusion solids 5.0 g, Proteose peptone 10.0 g, Glucose 2.0 g, Sodium chloride 5.0 g, Disodium phosphate 2.5 g/L) +0.6% agar)를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% BHI 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(엔테로코커스 패칼리스) 배양액 150 μL에 혼합한 후 0.6% BHI 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1 M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% BHI 탑 아가가 포함된 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 BHI 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, BHI 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 1에 나타내었다.
도 1에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 엔테로코커스 패칼리스에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예 1.1에서 확인한 엔테로코커스 패칼리스 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0×108 PFU/mL로 희석한 후 전배양된 엔테로코커스 패칼리스 1.0×109 CFU/mL과 혼합하여 MOI (Multiplicity of infection)가 0.1이 되도록 하여 35℃에서 120 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 박테리오파지 EF1(Bacteriophage EF1)로 명명하고, 2016년 9월 30일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고 수탁번호 KFCC11692P를 부여받았다.
실시예
2: 박테리오파지 EF1의 전체 유전자 분석
박테리오파지 EF1의 전체 유전자를 분석하기 위해, 박테리오파지 EF1 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL가 되도록 TE 완충액 (Tris-EDTA, pH 8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국). 시퀀싱 결과로 얻은 박테리오파지 EF1의 유전자 맵은 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 박테리오파지 EF1의 전체 유전자의 크기는 141,996 bp 이며, GC함량이 32%, 전체 ORFs의 수는 172개임을 확인하였다. 분석한 박테리오파지 EF1의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예
3: 박테리오파지 EF1의 형태학적 특성
박테리오파지 EF1의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경 (Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 EF1은 정이십면체의 머리를 가지며 긴 꼬리가 있으며, 보다 구체적으로 박테리오파지 EF1은 머리 부분이 약 100 nm의 크기이며 꼬리의 길이는 약 400-500 nm인 사이포비리대(Siphoviridae)에 속함을 확인하였다.
실시예
4: 박테리오파지 EF1의 단백질 패턴 분석
박테리오파지 EF1의 단백질 패턴을 분석하기 위해, 1.0×1010 PFU/mL로 준비된 박테리오파지 EF1 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 EF1은 55 kDa, 48 kDa, 40 kDa, 35 kDa, 31 kDa, 그리고 24 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예
5: 박테리오파지 EF1의 다양한 세균에 대한 감염성 조사
박테리오파지 EF1의 다양한 세균에 대한 감염성을 조사하였다.
우선, 박테리오파지 EF1의 엔테로코커스 패칼리스에 대한 용균 활성을 확인하기 위하여, ㈜옵티팜에서 분리하여 보유하고 있는 엔테로코커스 패칼리스 균주를 대상으로 소프트 아가 오버레이법을 수행하였다. 그 결과를 표 1에 나타내었다.
대상 세균명 | 대상 세균수 | 용균 활성이 확인된 수 |
용균 활성이 확인되지 않은 수 |
감수성 비율 |
Enterococcus faecalis | 12 균주 | 12 균주 | 0 균주 | 100% |
상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 EF1은 엔테로코커스 패칼리스 12 균주 모두에 대해 감수성이 있는 것을 확인하였으며, 이를 통해 엔테로코커스 패칼리스에 대한 용균활성이 탁월함을 확인하였다.
다음으로, 박테리오파지 EF1이 다른 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.
표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 EF1은 대장균, 살모넬라 등의 다른 균주에 대해서는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 EF1은 엔테로코커스 패칼리스에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예
6: 박테리오파지 EF1의 pH 안정성 조사
박테리오파지 EF1의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH3, 4, 5, 6, 7, 8, 9, 10)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 EF1 배양액을 1.5×108 PFU/mL로 준비한 다음, 상기 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 EF1은 pH4-10의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 EF1은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
실시예
7: 박테리오파지 EF1의 열 안정성 조사
박테리오파지 EF1의 열 안정성을 확인하기 위하여, 20℃, 30℃, 40℃, 50℃, 60℃, 및 70℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 EF1 배양액을 2.0×107 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 30분, 1시간 및 2시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.
도 6에 나타낸 바와 같이, 본 발명의 박테리오파지 EF1은 20-70℃의 범위에서 약 30분 이상 안정한 것을 확인하였다. 이를 통해 박테리오파지 EF1은 내열성이 우수한 박테리오파지임을 알 수 있다.
상기 실험으로부터 박테리오파지 EF1은 장알균, 특히, 엔테로코커스 패칼리스(Enterococcus faecalis)에 대한 특이성이 매우 높고, 장알균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 EF1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EF1은 장알균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 EF1을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예
1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 EF1 1 × 106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으로 제조한다.
1.2
액제의
제조
박테리오파지 EF1 1 × 106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 EF1 1 × 106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
SEQUENCE LISTING
<110> Optipharm.CO.,LTD
<120> Novel Enterococcus faecalis specific bacteriophage EF1 and
antibacterial composition comprising the same
<130> 1-35P-1
<150> 10-2016-0178129
<151> 2016-12-23
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 141996
<212> DNA
<213> Bacteriophage EF1
<400> 1
cctgagttcc tgactcaata aaaattccta gttgatttgc taaatctttt aatttagttg 60
acaacataaa taatacctgg tcttcacgta atttcatacc atttgaaata gaagcaattt 120
ctgctaagaa tttcatagat gtatgaatat aatcaaaacg gaaatattta acatcatgtt 180
ctcgataata ttttctaata gtagcttcaa tttctgtaac agagaaatct gaaataattt 240
caaaatataa cggagcctca gacataattc tagctccttc tctcaatact ttttcttggt 300
cttcgtcaaa tttaccatct aaaattatat cttcaggaat tcctgtaaga aatgctaatg 360
ccattgtttg acattcttct gaatctaact ctgtagaaat aaataaagaa ccttctgctt 420
ctccattgtc aacccaagct tgtttatgtt ggtcataaat tacagggaag gcagagtaac 480
aagctcgaga catcataata cgagatttcc cattccctgt tggagctgaa tacaaataga 540
atttacctaa tcgatctcca cgagttatcg tatccatcat tgtaattgga gaaggtgaac 600
caaaatctgg ggcttcttta aaagaatcaa ttaaatttaa taatccttca ccagcttgga 660
tactttcaga agctacatta cttgcagaag tatccataat atgttgaata ttatctgaaa 720
tctcatttgc catatccttt aaagaagtat gttcaaacca attttgttga taagcaatca 780
attcttgatt ctctgtatcc caatcataaa actgttttac agatacgcca tttttctcaa 840
gagagcgaag tagagttaat tttttaattg tgtctagggc tggctcaaaa gctgttggat 900
ctcctacttg tgatagttta tcaaagtaat attcaccttg tcgagcatat tttccttcag 960
caatttctat ctcttcatca aataaagtat taatttgcgg acgaccttga atatagcttt 1020
ctattatacc taagctaaat tttggatgtc ccattgaata taaattatac ataattgcat 1080
aagaaacttt ttgtaagcta tccacaaaat cagcttcgtt caccgcagcc atcttaggat 1140
gatcgaataa tgttggttgt acatataaag ctcctaataa catattagca atgtctttac 1200
gataatactt catttattta cttcactcca ctcatatcaa tagtaattct tttagtctta 1260
tcttcttgta aatcagaaat aattgtatca aacaattttt ctaaatcatc tttgtctttt 1320
cctttaataa aaattaattc tgtttgattt gtgtctgcac tgatatcttt tacataaatc 1380
cgaaaacatt gcttaaacat ttttattttc ctcctctgat aataaagaat ctaaatcaat 1440
taatttttct agtcgtttag ttttttgtgg aggaacaaca acctcttttg tcttatattc 1500
tattttagta acctgttcta aatgttttag ccccttataa taatctcttg cctcattata 1560
aaaataagga agtaaagcta taccactttc aggggttaat cgtttctttt taatatcaat 1620
taaataataa agtgttccca agagaccaga ttcagtgtaa ttaaattttt cagtaaactc 1680
tttaatctgt ttttgaacga gaggataatt aaccttacca ggcgttaact gttctaataa 1740
atcagttata cctgctctct tggctctttc ttcctgcatt gtatcgtaac aagttttatg 1800
atagtatcct ttggaagtat gttcaaacag ttcttcttcc ctgctaaaat gttgtctaca 1860
atattgacaa ataacttttc tttgtttagc cattatatgt atcctcctta aaaaagaaaa 1920
gcgaggaagt tattcctcct cgctcatcaa attaatctta ttgttgtgaa gcagccaaat 1980
ctttcaagtt tgtaattgct agatctacta attcagcttg ttcaggtgta gcatcggcta 2040
ctttattatc atgacctaaa gcttcattta caattgtacg aatacgagga ccatagaaat 2100
cagcattagc ttccattaat tctccagcaa gattattgaa cgtttcaatt aattcttcga 2160
taggagtatc aattttattg tatttatgaa ctgtagaaga attatctgtt acagaatcaa 2220
ccccaaattg ttgttctaga tgagaaactg catcactaat tgctcctacc aaattatcat 2280
aattaaatac gatataatca ggagtactat caaaacgaga accagcgaca aaacgaggcg 2340
ttcctcgcat atatagacga gtttccaaac cttcttctgt atttactgct cgtgaataac 2400
caataatatc agccatacga gtaataattt tattaccacg tttatctaat gttggaataa 2460
tttggttata ttcttcgcca gattcatctt taaagacctt atcttgagaa tgagaaatca 2520
taactaatcc ataatcttca gccatgatag aacgtaattg ttcatcaaat tctttttcta 2580
ctaattgata tcctttacca taaggtaatt tcttttgatc tgcaatatct gacgcaccat 2640
gctggttaac aataaatttt tcacatagtc cgtatgcaat atctacagta tcaataataa 2700
tattatcata catttctttg gcttgatctg tttttaactg ccgtagaact tttttaaatt 2760
cagaccaact gttaattggc aatgctctta cgccaggaat tgcagaataa cctttttcaa 2820
aagccaatag caaagactta ggaaatcgtg ttgctgtagt agttttacct gatttaggtt 2880
ctccgtaaaa cattactgca tatcctttta aatctttaga aactttatga ggctcaacat 2940
taaaaatgtc aattgtgttt gccattgtat cactatcctt ttctcttttt tattttattt 3000
tattaatgtt tccaactaga aagagaaacc gaagcttctc ttcctaagta gagcattaat 3060
tagaattcaa aagtctttgc tctgtcaact tttggtgctg tatctttttt agatgtgtca 3120
gctgcaaatc cacttttacg ttgttgattg tctaaagccg caattgaaac ttcgtaagct 3180
ttacgcccat cttgaattgt tttaaataat tcatctgtaa tttcttttgg ttcaatagct 3240
gcaccagtaa ttacattttc tcgttttgta ctttcaaaga tttcaatacg agtatcacca 3300
aacgctgatt ctgtttcacg ttcttcatga attagattat taatcacttt accccatact 3360
tcaatcaaaa ctgggtttgt ttgacttgcg tcaagctgaa cgaaataatc gtaagcagct 3420
tcagtttcaa taataaattt agctgggaaa caaacgtcac gataatcaaa gatgtttgca 3480
ttcaatacat atcgtccagt aggctcatct ttataaattt cttctacagg ttgagctgtt 3540
aatagcaagt ctgttgtaaa ttctgcacga ggaacacctg tgtttcgatc gtttaagaag 3600
cttgctcgaa tttgagttgc ttcaattaaa tcaccagctt gatttttaaa agcacttgaa 3660
ctaatagaag ttgttgtcat ataatttttt ccaatgaatg cttctggatt ttgtaaccaa 3720
ttgctgatag ttgcgaactg ttgatttgta gaaccatctt tgttcaattc acgataaaaa 3780
ccttgaagat ttacagattg gtctccagta tttaaagtta atgatccaac cattgcattg 3840
tacggttcac cagagctttt atctttatac tctttaactg cgaaatcgaa atcctctaat 3900
gtacctgaaa tttttacttg atttttaaaa gttgccataa tttaatttcc tccaatattt 3960
gtttatcttt tatattatat taatattata acctatttaa ctaaaaaagt caaattttat 4020
ttttttggac cagactcttt ccatcgtttt aaagctactt gtaaacgatc attaatttca 4080
tactcttgat aatacctaac tcgtttacaa accataatat cgtttccttt atattctgct 4140
ccaaaaactg gtgaactatg tttaaaagat tctttgacta aatcttctaa atcttcacga 4200
ctaaatactt tataatattt atctaaagct tgcacaatgc ttgtataatc ttcccaagta 4260
atcccaccat ctggactaat ttgaactcct gtggtatgga cacctttctt gattgggaaa 4320
attccttcct ttttaaggaa cgcatttaag tttcgagaaa aacttttaaa aattttcttt 4380
tcttgctttt cattttttgt cataataaaa tcctccataa atacttttta atatttctta 4440
tttaacttta taattaatta tatcatgttg aacataaaaa atcaaatttt taattaggaa 4500
taacagcttt acctacaata gcttttccaa ccactgctgt tgttgcatct tctggagttc 4560
catcattaat tgttcgttca acatatctag ttaaatcaat atcttcactc atgactaaac 4620
catgttttgg acaatataga tctcctgatt tatcgtctaa tttgcgatac acatttctca 4680
taactctttc ttcatcataa caaattggac aaaaattgtc aagatttaaa tttactttca 4740
taataaaaga ttcctccttt ttcttgtctt tataatttaa aaaggagaaa tcatccatta 4800
ttattcgtcg tcctcaataa ctaattctag ttcactagga ctacaattac aatattgttg 4860
aaaaccatga tatttacaat ttaaagtttt ttctccatgt tcattttttt cagaatataa 4920
acgaattaat ttatcctttt cctgcttaca tactggacaa aaatatttcc tagaatagta 4980
tctaatcata ttactcacca aattctcgtt ttaacattaa attaatttgt tgaatattaa 5040
aaccagttgt taaaactgtt ccatcttctc gcattaatac tggcaatgat aatacattac 5100
ccttttctac taattcatta tatttctctg gatctttttc tttatgaaca cttacaatat 5160
gcttgttata tttttgcata tttttagttt ttaaataacc ttccaattga ttacaatatg 5220
gacaattatc ttttgatagt ttataaatca aattatctca ctactcctta ataaaattat 5280
taaacatttc taaatcttct ttatgctctt ctggaataaa agttaattca aacttaatct 5340
tagggatatc tttctctaaa ataatttgaa tattatctaa tgctccgcag aaatgagtat 5400
aaattgtaat tccactacca aataataaaa ctggtttgtt tattaataca tctctattag 5460
aaattacaaa agatttaata tttttaggaa tctttccatt actccatgtg taagttccta 5520
taattatttt atcatattct tccaaatttg tcaagtcatc ttttgtattt tttataataa 5580
aattaacatt tgggtaagcc tttactataa aatcaacaaa agtttttgta ttcccagata 5640
gactctcata aactacaagc actttaggtc caagagagag agattctaca tgagagggaa 5700
ttgccttggg cggagctaat tttactccac ccgtgcaaaa tgttttttcg ttattatcca 5760
tattaaaggt cgtcccagct atttttgtcg tctgttgctt tagaataatt tactacacga 5820
ttttcaaaga aatctgtttt tgtattattg atattatctg aatcgtaagt cttaatccaa 5880
atcattggat tagttaaagc ttcagtataa actttggtta agcccaagtt ttgcaacaga 5940
atattagcac gccactcaat atagtgttct aattcttcca tatctaaaac agcataatcc 6000
ttatatagat ctcgagctaa ttcctgttca gatttaacta ctttatcaaa gaacgcataa 6060
acccaattac taaaatcttc actctcttgg ggtgaaagat gtaattcaga cataatttgt 6120
cgtacaacta acgtttggaa ataactatgt tgtacttcat cacgctggat caactgaata 6180
atttgtcctg ttcccaacat ttttttgttt cggtttaata agtaaaatgg agtaaatcca 6240
tttgtaaatc taataccttc aagtgctgcc atagctgcta aggctttagc catatttagt 6300
tttgttggag tttccaaaaa tgtttcaaat gtatccaaaa tcatttcact agaaccaaga 6360
atatatttgt ctgttttagg gatttcaaat acttccttcg cttcttcttt cgtcataaaa 6420
gtggtagcaa tataagtata actttcatta tgaattgatt cttgagaagc aatataagcc 6480
ataatagctt tgatagcagg gtttttaata tacgctgcca attgaccatc aataacagta 6540
gaaatagaat ctagtaatac taattgagaa atagctcgtt tgtaaaaagt tttttcaatg 6600
tcgctcatat tatctcgcca atctctacta tcagtattta accctacttc ttgaggtcgt 6660
ttatattcac ataaagtcgc taattttatg cagttctctt atgaacttct atatgttacc 6720
atatagacta gactatatct taaatagagg cgttaccctc taagtctcta aatttcgatt 6780
taaaggattt atcatgtatg ccattttcgc atacactacc taccgcttgg ccctactcta 6840
ctcggttctc gctaattatc ctctcgacaa taagctaccc tttcgatagt cgttacaatg 6900
ctaaaggtgt ttccaagtat aacccccttt aattctagct atataactag gggatagacc 6960
atatctttca cctagtacac tatttggttc acttgatttt ttaatttcta atgcttgggc 7020
ttctgttatc ttagaatttc tatttttctc cccaatattt gtcataagtc catttgtata 7080
ggcatgataa atattttctg atggagatac ccattctaag ttttcagccc tattatcatt 7140
tgtttttcca tttatatgat taacctgttc tttattttct gggtttggaa caaaagcttc 7200
tgcgacaagt ctatgaacct tataatcttt tccagctaaa ttaactctta agtatccacc 7260
ctttttctgt ggtcttcctt ttaattcttt acctgttgtt tgattataaa ttttcccatt 7320
gtctgacaca gcatatgtgt gaccaaaacc attttttatt ccttttattt cttttatcat 7380
attttaatgg aaacaccttt agctatctcg gtattgtccc ataaggagtt ccaccgattt 7440
aatagagttt tacttggact acctatttaa tccaaaaatt ttgttttagt tctgaatata 7500
cgtcatacca tacaggattt tgttcgtccc aatataataa tccagaatgt tctccaaaaa 7560
ttgactcatt tgtattttct gcatctttat taaataatct aatatgtttt tctaacatta 7620
aaatcttctc ctttatacta ctctgaacga tttgtccatt catcaattga atctaaccat 7680
tcagaaaaat catttgtttt tcgattttca tcaacaacaa aacaatcatg aagatagcta 7740
ataacttcat cttcagtttt atatccttta ctttcagctt cctcagtaag gtcatataag 7800
ttttgatata agaccttacc atcttctgta aattttgctt tcatttttta caaatcctct 7860
acattaaaat gaatgttctt ttgtttcttg taagcatcta aataaatttc ttccttgtct 7920
ccatttaagg ttacttcata atacatccca tcagaaattg ctgtagacaa aagtaattta 7980
ctattttgta gtacctttgt actccagaca atatatacat cttctaaagt atagtctccc 8040
tctaagtttt cgttagaata atctaagacc aattttttgg ctgcttttac aaataattca 8100
tgtgtcattt attttcctct tttctttaac cttatatatt tattatatca taataaataa 8160
ggaatttcaa ataagaaatt ccttatttca aacttgttcc caataatatc cataggcaga 8220
tttaattttt ccagttgcag cacttctaat attaccacta ccttttttta aaaaatctgc 8280
agcttcttta ctatttttaa aaaataaaac ttctcctgtt tttttatggg ttgcttttaa 8340
ttttatactt cttttgtcag cagaaattct agatcccttt tcagaatttg cttttgatag 8400
tccattatta taagcatgtt gagtattctc agatatagtt gcccattcta ggttagaaac 8460
aacattatta agtttatttc catctttatg gttcacacta tatttatttt ctggattttc 8520
taaaaaagct attgctacta atctatgagc ataaaattgt tgcttctttc catccatata 8580
gagagtatgt tgtctatagc catggctatt aattccgcca gacaatattc tatttcctct 8640
ttttaatctg ccataggagg agatctcata gacctcccat cccttgacag gtaaccataa 8700
ttctttcatt cttttctcct taagagctgc aagcaacaca atcatctaca cgagaagcgt 8760
catgagaacg agtataataa gaagatttaa ttcctctaga ccaaacttcc atatgaagac 8820
gaagtaagtt tttaacctta atatcatcca agatatataa attaaatgaa gtagattgat 8880
ctacccattt ttgacgttct gcgttgtgga gaatagccca catatgaccc aaatctctct 8940
ctccttcaaa ctccattaac atagttggtt tataatagaa ccatgtttct aaatttagtt 9000
ctggagcaat gacaggtgta cgagaatctt tcttaccatc aaaaaagata gtgtcataaa 9060
ctgtgtctgc cgctgcagta gaaccagcta ataaagaagt agaacctgtt ggagcaactg 9120
ctcttaaata tccattccgc atacctttct tagctttgga ataaacctct gctcgataag 9180
catcctcaat atcatcttga caaactcctc gatgatttaa ccattctcct gtgttccatt 9240
gacttccttc aaacaaagga taacttcctt tttcttgggc taaatctgcc gacgcctcaa 9300
taatatttag catgattctt tcttctaacc gagcaattaa tttagttgct tcaactgaat 9360
caaaatggat tccttgttta gccaaaactg ctgcaatacc ttgttcacca attccaatag 9420
cacgataacg attatttgta tattgggctt gtaaaacagg taaattatta acagtaataa 9480
ctgcatcagt agcacgaact tgaatacgta aaacctgtct taatttttca aatgctttaa 9540
catcgtcgct agtttgcggt ccttcaatag aaagagtaaa atctttcaaa acattgttaa 9600
gaacaataga agataaatta catgtcacaa aatctccact ttgtttatga acaataattt 9660
cccctaattc attaatagtt tctttagtca taattgtagg agattgattt tgtacaattt 9720
cgctcttata tgttcgattg aagtcgttaa tttcaacccg ttctcttatg aactgctata 9780
tgttaccata tagaacagac tatatcatca ccctttttta aaagggggct accgtttcgt 9840
ttaaaggact tacccgatta ttactcggaa gcctagccac ttggccctac tctactccca 9900
caactcgtgc tcggtttcga tagtcgtttg gcatttagta taaagtctaa tataattagg 9960
aaagtttttt gagtttattc tataatgtat tgtcgtattt ccaataccta gaatcctaga 10020
agcttcattt actgaaggat attcaatccc attaattaaa attggcttac tatttgcttt 10080
tttaatgctg tcaatcattt tctgtgtttt aggtttacca tacattgggt ttcgacaacc 10140
agaagaatta atagatttca atttccttgt atattcttta ttcgggttgt tcgtaaaagt 10200
gtctcctcca attgaggttg cttttatatt ataaaattct ttacttttta cagcgtcgaa 10260
ttgcataata taatattctt ctacttctcg aagttcttct tcagaatcac attcatcaat 10320
aataatctta aagaagtttt cctttccata tttagaaatg gctcttttta gataaacccc 10380
acttcctaaa tatttctccc aattattttt tcttccataa acacattttc ctatatattt 10440
catattattt attttgttta ttgtaatata tataaaacca tatctcacaa tatctacctc 10500
ctcggtagac tttatacatt tagcacagga ttgtcttttc ttaaagagtt tccctgttta 10560
gatagctttt tcgataagga ttgctcctta aaggtgctag tttatcaaca caaattagag 10620
cagtatacca ttcctgcatg attgttagga ttatctctat ttgcagtatc tcgataaaac 10680
atataaggca aaccagtttc tagttgagaa cgcataattt ttttcataat ttcaatagct 10740
ggcaaacgtt tctttaaatg taaatcgtta ttatctacag ccttaaaata gtgataagag 10800
aaagcgtgac gatcaggatc tagcggtgat tttccatccc atttttcttt atcgtagaaa 10860
tcttccagag aaaaacctaa tacttttttc acttcgtgag ggtcaaataa ataccagtct 10920
cctcgttttt ctacttgttg cataaataaa tcaggaatag aagcacctaa aaatagttca 10980
tgcgctcgtt tagataggtc tcctgtattt aaacgcaact ctaagaaatc ttctatatca 11040
taatgccaaa catctaagta tgctgcaata gcaccactac gaactcctaa ttggtctact 11100
gaaacagcag tattatttaa ttgtttaagc caaccaacaa tacctcctgc agcaccaaca 11160
tttcctctaa tatctgaacc agcagcacga attttaccca cataaaccat gttattccac 11220
tatttctagt ggcatagact atatcttcat atatttgtta gatatatgct ttgcgctacc 11280
caattgggta tctcacccaa aaggtctcgt ttggttttcg tttggaaccc ttgattccaa 11340
gctatccaaa catttagtcg ttacacctta cttatatcta tatccagaaa atttttcact 11400
tttagaattg agtctataag agatagtttt tctatcaatt tttaattctc tcgcagcctc 11460
atttatgcta atatattcct tgccttctat taaaattgga atatttttag gactgcaagc 11520
tctcattttt ttcttccact cttctgtttt tggaactccc ttaaacgtct ccctagcttt 11580
ctcagccaac aagcgtttgg tttcttctat atgcttttta ccatagaagg ggttgctttc 11640
ccctttgtat ctaatagaag cttttgagcc aatctttaat ttagtttctt ctgaatgatg 11700
cttaccataa aagccattat cagaaccata atgaatatag tttccagggg acctcgagct 11760
tttagaaatg ttatattttt cctcctcgag attcaagtaa tattcttctc gttcaaaaac 11820
tttttcttta tcttctattt cttctaaaat agtaaaaaca aagttttctt tcccgtattt 11880
attaaaagca ttttgcagtt tagaatttat gtgtttgttc tgttccaatt ctcgaaagtg 11940
cgttgttttt cgtctttgag gattattagt tcgtccataa tattttatgc ccgtaaccaa 12000
attctctatc tggtatatat attctatttt tatcacatcc tttttaacaa aggatataga 12060
tataagtctt ggcacggtat tgccatatca tttctgactt aggtttcacc gttagcatcc 12120
tgttaaggac acaccctatt ttaggttcac aaagttttaa atcggcattt taaagtttac 12180
cgattcctcc cccagccttg cttaggcgag cagcatctgt attgtcatca tagatccctt 12240
gtaagctatc atctgttgtt aaaataaagc aactagaaaa ttgtgcatct ggtcgtccag 12300
catttgcaaa tgttggggta gccatagtaa cttcttgttt agatagtaca tcatataatt 12360
cttttacatg ttgtagtcta tcttgtgttt cttctcttaa taaagaaatc gcaattgtca 12420
tataacgttc ttgtggtaat tcaaatactg aacgtccttt atctttagct cgaataagat 12480
atctttcaga catattgtat aaaccagcgt aagtcaaaag taagtctcgt tctggcttaa 12540
tatatttacc taattcttga atttcttctt tagtatattt tacaaaaatt tctggttcaa 12600
taagaccttg ttcaccaaga gaagaaagaa gaccaaaata atcaccatat tttgaatcaa 12660
catcataact tcgatttttt gaagctcgtt tatacaacga atttaataga gccctagctg 12720
ctacaaattc aaattgtgta ttgcctaatt tatcaaagtc catcatttct ccatctttaa 12780
agtccatgat tctatcaatt gcattttgaa taataacatc attgatatct cggaaatcaa 12840
tctcttgtct accctggatt tgtttaataa cacccttctt atatgcttca aatgtatctg 12900
gatgaacgtc caatccttct ttaaagctat ctaatttatt aattaatcgt tgtggatcaa 12960
attccaattt tctcaatcca ttatctttta ctactactgt caaataaatc tctccttttt 13020
taattctgta atctttataa aacccaatat atagatattt atacggaata aaccacctta 13080
tatagaagca tatttaatca aggcaagtaa gacatctatc aatccattat tacaatcgat 13140
aaatactgat tcagcttttc cttctcgtcc tattacagaa acctcttttt tgtctatatc 13200
tacaatcata gctgtatatt tccctgtggt agaatataaa ataaacccac tagattttcc 13260
atcctcatca tgtttaatgt atatttcatc ttcattatat cctaaagcat ctatgatata 13320
aaaaactata gttctcatat ttgttcctgt tgtttcttta tcaaaatata agctcatgga 13380
tgaaataaaa tctctctcat aagagtgacg atcataaaac attaaattta aagaatcttt 13440
agttattata ggacttactt ctattcttcc ttttggagaa tatattttgc cctctaccct 13500
taaaacttta gagcggctaa tttcatttac aattgcactt acctcttcta atggtctcat 13560
atttttctcc ttttaaaatc attataaaat aaaaatcctt actatataaa gtataacata 13620
gtaaggattt tttgtcaaat tatttaattt tagtaccagc cattagccat ccaaaaagct 13680
tgtgccgctt cccatgaacc ataacgttga gctacataat tttctgcaac acgttcttgg 13740
tttgctggag aatgatctcc atttagataa gctgaatcta gttgataacg tccgatgtaa 13800
cgaccattcg ttgctgagta tgagccacct gattcacgtt gagcaatcca ttcttttgct 13860
gaatttgttc ctgttgaagg agcttgttcg acaataggtg attgttctac tactggagct 13920
tgttctacaa cgttttcttg cacaactgga gcttcaacta ccgctgctgt tgctggagcc 13980
tgaacctctc cattggttgg aatcaataat aaatctccag caaaaatcat attagcatca 14040
ctaactgtat caaggttaga ttgatggatc aaactatgat ctaatccata tttattaccg 14100
atagcagata aagtatctcc tgcttctact tcgtaataag tctgtccatc tttttgaatt 14160
tctgctgcgt gaacacctgt tccaccaata aataaagctc ctgctaatag tcctgcgata 14220
ataattttct tcaaattgtt attctccttt ttcttttagt ttttcgttaa gcaatgaagc 14280
atatccattt gcttcattaa attctaaaaa cttaattttg gcaacactta agccagtaaa 14340
acaatttcgt tgagaatcta ctaaagcttc tcgttcaaat tgtgctgaat taaagttgtc 14400
tttcacaagg tcgaaaaatg gaaagacgat atccccatct tctgaaaaag gaacgtctaa 14460
tagaaaagcc tcgtaaaccc aatcatctaa tgattccaat ttcttattta caactttata 14520
cgcctcttta ccaaaaatag tttttgttgc ttcaacgatg tattccatat gaaattcccc 14580
ttttcttgtt ttaataaaaa agaccctatt acaaaattat tacagttaaa ttacattaaa 14640
ataaccgtga ttttttcttt gtaattttta ctgaagtatg aactttatta tcatcttcta 14700
cagtaatttg attattttta actacaacaa cagggtaatg ttcttcaagt ttttctgcta 14760
atttttctac aaaaggattt agttttttag ccacaacaac ttctccttct gcaacttgag 14820
gacttttatg tcgagttact tttacttcat aaaatgtgtc gccatcttta ataccagcaa 14880
tacgtttttg agaatccaaa agtttaaatt caatatcttc gtcctcttgg agaaaaccga 14940
acgccatatt cgctaatccc catttgtctg cagtcatttg ttttgttgga gtagcacgac 15000
ctgcttcgat taaataattg tcccaatttt tcataatttc atattcaaat tcttgatgct 15060
taggatctga tttctttatg ccgtttttca aattttcttt aaattttcta cctgtaataa 15120
tagtattata atacatagac ataaattttc tatcctctgt agtttgttgg aatgcaccgt 15180
atttgttttc cataaaataa aaactccttt taaaattctt ttatttctta actatatata 15240
tatatattat catttttaaa taaatttttc aaattattaa attaaaaaag gctgaggaaa 15300
actcagtctt ttttaataga aattattctt caaccttttc ttcaatctct ttttcttcaa 15360
ttgttggggg agattgtagt tgttgaatag cttcaagcaa ttgtttattt gcagcttctg 15420
atttagccaa taaaacttct tgtcttgcta tttcacccat tgcttgagta agtaattctt 15480
gtgttccagt taattgttgt cgagcaacag ctaattcaaa ttctgcttgt tctaatagct 15540
gttcaaccgt tggatgttga cctgttttat tttccattat tgtgttacct ccactgatgt 15600
ttttccatct tctgaaattg caaaatgtcg aactttatta gtcatatctc cagtacgatt 15660
tgctctaata cgttcataca tagctgtttt tcggtcaatg aatgcttgga tttcattttc 15720
taattcagac ttcatttgtt ctaaggtttc aaaagtttca tgatccattt tgagatcccc 15780
taagttattt aggatatcaa tataagaacg taataaagca atacgagtac ctactttttc 15840
tgttgccata tctaaatcat ctggatgagt ttgactaact ccggtgcctt tgactatatt 15900
accatcaatc agttctgctg tagtaataac agtcacttta gatacgacat taataccatc 15960
tacttctaca aattctggaa aagaatcaga tgttataatt cgttctaata catttttaac 16020
ttccactaaa atttcctcct tatttaactt tataattaat tatatcatct ttaataaaaa 16080
aagtcaataa ttgtctcgcc aaacaccttt tatttttttt cgtgcttttt gtctagttaa 16140
tggataccat tgttcacttt tagctttttt taaaatttga gcttcaatgg gaatccatct 16200
accatcacta tcttttctat atattaacat attactctct ccctgtcaag taaattaaat 16260
tttaatccaa atatctcctt ctctacctgc tttacctgga tcagtaacac taaagaaaat 16320
tctaacccct ttaaatgata tatatgattg ttcagaagat aatgcagtat ctgttaataa 16380
ttcaccatcg ctcattctta aatagtgata atatccgctt tctgttggtt gtccactacc 16440
ggcgtaattt ctagggaata aaatagctgc atcacgacta ctagaataat ttctaaaaac 16500
aagctgtcca ataccattca ttgctccacc attaatatca atggctggtt tacgatttaa 16560
attacctaca taagttaaat taggttcaga aatttttagt gctggcatac ctaaataccg 16620
tttagtatct ccaatagtca tttgacccgc aggaatatga actcgtccaa aattcaatgt 16680
caaagaacca ccagtattcc catcgacacc accaaaaata atatcattta attctgttcc 16740
accattacca cttgccgcta taactaacga atctgttgga cttattggaa attgaaaatc 16800
taatcttcca aaactatttc taatacttaa tgggagtcct gaacggtttg tatctaatac 16860
aagacttcct gtcatagttt gatttatagt tttatctaaa taattttcat gtctatgatt 16920
tactggagct aaattggtat gagtgtgatc aataggtgaa tatcttgctt tcattgtttc 16980
taacaaagtt ttaccagcag atgctgccaa tgctctatca gaagctgaac tatctaatgt 17040
agaaactagt tcatccttac gaacatattg actgaaatca attccacctt cgcttggaga 17100
tgcaccagtc acttcataag gaacaaaggt actaccattc caaccaagca atgtattaac 17160
ttttaaattt tctcccagcg tgacatcttt aagttctcca atagaagagt tggttgataa 17220
tactgatgct cctcctactc gtaatgctcc agtaaaattg ttccaatctc cttcccatat 17280
attgtttcca cccttaagag ctattaaggc tgcctctata ccttgatctt gaacaatttt 17340
tgtaatctct ggtaccaaat cagaaaaatc tgatactgta tgtttgtgac ctttttgaga 17400
aacctcattc catgattcat tattttgtcc tgtagctacc caaatagctc taggatttga 17460
acctgtatca atataagttt gtccataata ttcagcacta atagttggtc tacctgtgcc 17520
gtataacata tttcctctag taatatgaat tgacatttat ttgtcctcct ttataatctt 17580
tctcttatgt atattaaaaa gcttttaaac ctaatataaa aaaagaaccc taaaagatta 17640
aagggttcaa aaactttctg acttttttag aaaaataata ccattggaaa taaatttctg 17700
tccccaataa gtatcttcta tttctttata ctcatcttga tttacaggaa ttggcaatgt 17760
acttcttaca atagtttgct gtttcatgat ctcttttttt aaacgttccc tttttgtata 17820
tttggttacc atataaggca atataaatat agcaggaaaa actaaaagca ttgaaagcaa 17880
aattataaga aaagaacgga aagtaaaaat agaaactact ctatcttctt gctcccacct 17940
tttggctgga agtataattg attgctcagt aaaattccag cgttcaatta ataaatctct 18000
tttttcaatt gcattccgag ctttttctag ctctatttga tgccgaacta aaactctact 18060
attgaatagc tccactttta accctcctaa ccaatcagga atcctgtgtt tttctataaa 18120
attctttaac atgcgaaaaa caagctcgtc ctccttcatc tatctagttt cttaaaataa 18180
tttaatttgg tgtgaagaac ctttcacata atttactact aacatagcta atttaccagg 18240
atctacataa atagaattta atctattata aatgaaattt atttcggtta gatttgaatc 18300
ttttggctca tttactaaaa gattataatt ttctgacaaa tggtattcca atccagaaat 18360
gtttttaata aagactgaag taccatcata agtataatca aaatacttat tggcaacttt 18420
accaaaccat aatacatctt tctctgctag taaatacatg tctgggtctt ctaacaattc 18480
catgaaggaa ataatagaat ctctcgccac cttatttcct gcttctcttg gaagaatatt 18540
gccatatata ctataaaaga ctagatataa atcttcttta gtttttatag aacaagcttc 18600
attatctttt gcagtatatt ctattatgct atagtttata aatgaattta gaataggtcc 18660
gataggttta tcagacacaa aaaatctaat atcttccatt gaacgatttt ctaaatattg 18720
attaaaatat tctgtataga ccaaaggccc gctaccaaag atagcaggct gtccagtaaa 18780
atctaacatc ataaaattcc atctccttca gattctacat aggctttaat agctgtatag 18840
aattctgatg gtgcctcaaa accagcataa tttgctacaa ctaaacactg ttgtacataa 18900
tcaataaatt tatcaaaaat ctctggatta tccttgaaat attcatcagt atccttttcc 18960
atagtaaagg caagctttgc ttcgccctct tcttctaaat attggatacc aactttttca 19020
tcaacaatta attcaaagaa aaatttctca tactgtatat tgtccaattt tatcactcca 19080
atttccttca taggttttta actcacaatc tccacatata ggcatatcag aaaaagcgtt 19140
tgttttatta caagataaac attttacaac agatccatat tttaatatct cagattcttt 19200
tggcgctcct atatataaat tctctctttt tgattttata cctaaagtaa aatcattata 19260
tacttgactt aaatttgttt tataagtctt tatattatcg tcatgaactg agataaaatt 19320
ctctccaaga gaagagaaaa aggtgctttg taaagtattt attgtaaatt cttcaattcc 19380
attattttta tatggatatt gtgtagataa cattgctccc ttatagtctt ttgaaaaaac 19440
ccctagacgt ctataaattt ttctatctac atattcaaca tcattaaagt tgggtttttc 19500
tgtcataaca taagttaaaa atgtataatt atctaacgct gcagaatatc ctccagtata 19560
atgttctccc attggtttat aacatgtagt ccatcctctg ccaacaccca tcattatgaa 19620
atcataagga tgaacagata taaccaaata actggatgga agtatatatg agttctttat 19680
ttgagaatac attaatacga tttcttctcc tagttctgga gtttgattaa taaccttaga 19740
taattttttg ccagaagaat gtttattctc tattaaatct gaatcattta atagccctgc 19800
taatttaaag aagccagcgt ctattttcct ggtttcttta tatcgttcct taaactcttt 19860
tttaaaatct ctttctgctt gtgtttttat agcctttatg ttatctattt taaaaactaa 19920
tcttagatta ttatccatca tagcaattat ttcttttttc ttttcagtaa cttgactgaa 19980
aaaattttca taattattat acgaaaagag actaacccct tgagagaggt taatcttttc 20040
gtactgactt ttcatatttt ctgtcaaatt ttcaccatct tactttccgt cattatttat 20100
agctttggta taacgttctt tttgtgatac atcttccaag tatttttctc gacattcatc 20160
gcacaaatgc gacaatactt cattatctgt atcagaccaa ggaactgtcc ctttgtctaa 20220
aaagcaaaat tcacattgtt cagtttcttt ttttttattg cgacttttat agggaacaaa 20280
acttgtttca tcatcttcat aatttagata atccgattca tcataaacat cttcatctcc 20340
ccagtaacaa taagaaccat tttggtaata gttagaatat ccataattat tatatccagt 20400
ataagaatct tctttatact cataaaattt aggattttga tattggtctt ctaaaatttc 20460
ctttactttt ctctgagtct tatacatttc gttaatataa atgcgttcat aacatgtatg 20520
ttcatccata tatcccgctg ataaatttac tcctgcaaaa ccaaattcag gacaaacttg 20580
acaaatatct gtataagatc cattgtgggt tttaaatcca aagctgttaa tatattcttc 20640
aaaatctata ttatctaaat aataatagac agattctcca aagccttttc gatccaattg 20700
aatagcgaaa ttaatctctg tcaaggctgt ttgtacatct tctccaaaat aattttctac 20760
attttttgta aagaagctag atccaatagt tccaatttcc tcatcccaac aaaataatac 20820
atgaggacga taaccttgtg ttaacatatc taaaatgcta aaaactccac aacgatcatc 20880
cccaccaata ccatcgggac accataaaac atttttttct ttatcgtgaa aaatagtttc 20940
ctctgttgga gctactgtat ggactgtatc caaatgagcc aacataagaa caggaatatc 21000
tcctttagca taaataaaac taccatcaac acgataaata tctctagaat catacattga 21060
ttctatttga cctaataaat aaaaatgaag tccttcttgt gtcatttgta aaatgttttt 21120
aaaggtttgt aaacctaatt ctttcttttg cattttataa aattccccct tttttaataa 21180
tcccaatcat cttcgtcgtc ccaatattca tcttcatcat agtaagcatc ttcgtcaaag 21240
aggcctccag cttcaattga tccattaata gtgaaatcac aagttgggct tatgactgaa 21300
tcaacaccta cttcaaaacg aacattgcat aattcagttt catcagtttc atcataaaaa 21360
tccttattga aatgttttct taaaatgttt tcagaattat tttctccttc aacattgtat 21420
ttttgtttat ctaaaacaat cattggaact ttattcatag ctccatgtgt aatatcatta 21480
tagtgaattt cactactttc tctaatagta ttttctgcat caggagaatc aataaatcca 21540
taagcaacat tatcttctcc aaaagtatct acaaataatt tacgtagagc tttagtatta 21600
tttttattaa ctcctggata tgagcgagat aaaaggatag catctaactc tgtattgaac 21660
atacccattc tacgccaaat tttatctggg atactatctt gacttcctaa aatgatttga 21720
caaataaaac ttgaaccgtc taataaataa gaaactggtc cagcaccata acaaccatca 21780
ataatagaat gacaagaaga ccattctctg gttttgttta cagacatcat taaaatgtca 21840
agagggtcaa tagaaacttc taaaacccca cgagccaata atgattcatt aaaagctgat 21900
agataaatct gtatttggtt aactagtttt ttatttttta gaacacgctt aagagattta 21960
gaaatttttg ctccagcttg gaatgattcg cctaaaattt ctttatttgt cgtaaaacgg 22020
tttttttgta actcttctaa agaaaaacta ctaaaataaa gtgctataat tttcccttca 22080
ttttcttcca tagtcattga tttaatttta gataaaaatg aagaataaaa agcatcttta 22140
atttctgaat ttgacaatgc gttttcaacg cttccttcta gtcttagttt gtttccaaat 22200
ttctgaaaaa taggaaattt tgcttgagcc caatcttctg cccatgcttg tctagtatcc 22260
gtaacgaaac caccattgat gctatataaa atattatcaa tttcttccca agattttttc 22320
atcattggtt ccatcaattt taatttttct tcgatagtat atgttttttc cattgcaaaa 22380
tctccctttt ttattttatt attgtaaatt aaaatttact ccttgctctg ttaaaaaata 22440
ttttcgagga gtgtcagcag ttttttctac tagtcctttt ttattcaatg aagttaatac 22500
acctggaacg ccattaggca tcataaatgc taattctgct acacgtttag aaaatactgc 22560
atcttcttct ttatcaatat gagcctcttg taaagctttt agaacttgcg tacctttttc 22620
tgttaattta atttcttcca tttaaaatcc gctcctattt tttatttatt aattcatttt 22680
ctataatata attataacaa attgaactaa ctttttcaaa ttgttgtttc tcataagcta 22740
ttttatcttt ttatttcttt catttaactt ataattaatt atatcattca atatataaaa 22800
attcaaataa aaaatcccaa tcatctagat tgggattaat tttaaatagt ttatacacca 22860
gcaccagctt ggctaactgt aatttcaatt gtagattcat cagaaagagt agctgttcct 22920
ccagttactt gaccgccttc gtttgttctt aatacgatag ctttaataga ttttccatct 22980
gcaccatttg ctccagggac tccttgatct ccttggtcac ccttatctcc cttaggtccg 23040
gcaacaccag gagttccagc ctcaccttgg tctcctttag gtccagcagg tccgataggt 23100
ccagtttcgc ctgggtctcc tttaggccct ttttgttctt gcaagaaatc tactaaagaa 23160
gcaaatgatt cttgtgtcat agttttacca gttgcaaata atgctttaat ttgttctgcg 23220
ctcattttgt ttcctcctat tttttaaata tatttgagaa cttatctctt tttattatga 23280
aaaagtctta ttctgctttt ccaacttttg ccttacctac tatggctttc cctacaatag 23340
gctcttcacc tgaaacctct ccctttttat aagcaatagc tctatcagta ggacaaatca 23400
tataatagaa atcttccatc ttgtttttac gatgattgat aaccatacaa ttttcttcat 23460
attctcgtcc gcaatgagaa catacataaa tatctttttt cattctcttt cctccttttg 23520
gtaatcgcta atattattaa aaagacctaa tttgaaacaa taaaataaag ccctattata 23580
aaatagggct tttatcatat tattctttta cttcgccagt taataagaaa tcaataaatt 23640
ctttattaac agggttgtct ccagtcaaac gaaattcaaa ggaactatct tcaacaggtt 23700
cccatgaaaa atctaaagaa tctaaaataa ttttagtttt taattgaagt tcttcctccc 23760
gattttcaca tttaaaaata taatccttta aaatttcaaa acaatctttt ttagatatac 23820
ctaatccttg atactttttg aaaagttcat tcattttcca agcttcgtcg agaatttttg 23880
gtagttcctg agaaaagatt tctttccatt catcagaatc aatattttct gtatcttcat 23940
gatattttcc atcaactctc caaataaagc aatcatggat acaagcagtt gttccatctg 24000
gcaattctac aacatcttct tgaagaatat aactgtcaag agtttcgcac catgcagcat 24060
cagaatccaa gatatattct tctaaataat ctgagtaagt agcttttgtt gtataaaccc 24120
aagaatcttc tttagatcca atggcatgaa cagcttcttc actccaaata ttttcctctt 24180
cttcagtaga ccaaactgtt tcttctccac agtattcaca aacataaacg atatctccag 24240
aagtatctaa tactcgaacc ccatagtctt catcaaaacg ttcttcacac gatggacaaa 24300
ttgaacgtga accataataa cattcttcgc aaagtcctga gcaatttgag ggatcatctt 24360
tagagccaca ttcaagacaa acaaaagtac tttgtgcatt aattagaata gttttagctt 24420
cttcagcttg aaaaagaacc ggagatcgta aacctcgaat tgcatcattc cagttgaaag 24480
catctacata gccatattca ttacaatctg aaccatttct ccaacgaaag cgggttaaat 24540
tttcttctat ttggttaatt ttcgcattac cttcccaacc caataaagat aaagttgcat 24600
tactaatcat attttgcaac ccattattca aacgaggata tcctttttgg gacaaaagaa 24660
ctggaacggt ttcttcttca tggtcaactt cagaaacaaa catcatttgt cgccatactt 24720
ttggagctaa ataaccaaat tcttctaaat ctttttccat tacagtaaaa ccaacaaaag 24780
cgtctggtcc aaccatataa cctagtgtac cattattata ttcaccttca tcaggatgca 24840
tgcatgaacg ccaactatta ccataactaa ttaagaataa atcttctggt ctgatagata 24900
gaacaatttt tcgtccatca aaatttgctc ctgatgcaaa gctagccatt tctccaccaa 24960
caattttatt tttaatatca gaaatagctt cttttactcc tttagttgaa gaaatttttt 25020
gagcagttaa tgctgacatg tcaactaaag agtttaaaac tttagttaaa cgttgtccat 25080
gaaaaggtaa cattttaaat tcatctttca taattacctt tttattttca actctaattt 25140
tgtcaaaagt attacaaact gatgttttaa aagtgtcaat gaaattataa gaaatattca 25200
aatcacgtaa atcagaatat aaatcatctt ctacataatt tttcatttct tcaaatgaaa 25260
attcttccat aaaatctttg aaatctttag gatctaaaac aattcttcca tttgttccat 25320
caaagatttt ttgtaggtaa gagtttttca tttccattcc ttttgcataa taatctaaat 25380
attgtgaatc tgataatgaa ccccactcat aaaattcatt aaagatttct tttaaatttg 25440
ctttaacctc ttcaacgtta taatttagca taaatgaaaa actccctttc tttaacttat 25500
ataaatatta tatcatttta aaaattactt ttcaaataat gtttttaaaa tctaaacttt 25560
atttgaaatt tcgtttctaa aacttgatta caaaactatt atataatttt aaaaaaagtt 25620
tttcaaccaa gagcaacgaa gagtttaacc tctagttaaa aacatatttg actttttttg 25680
tttaatatat atatttataa atatttttta tttaaaaagg aagttttttg ttcatgtatt 25740
acaaatctgc tccccactat cactctcttg ggttgacttt ttcatgttaa atatatataa 25800
ttaatataga gttttgagta attctaagag taaaaattct tgactttttg attattatat 25860
gttataatta attataaaga taaataaaga actaaaattt gaaggagtgt atttttaaat 25920
gaaagaagaa attattaaaa aatttatgag tgccttaaat atttcaagag aagcagcttt 25980
agaactatat gattatgacg aacgagtaga aaaaagtaat aaacctgtag aaggagaaat 26040
tgtggttaaa aagattccta aaacttcaaa gaaaaaaggt attcaaaaag aagaattaga 26100
tgcaatgaaa gatttgttgt ctaaaatgtt ccctaatgga gaagagttta aaaatagtca 26160
attatctcca ttatgcgagg aattaaactt gactaataga caaactcctt caagattaaa 26220
agcattaaaa gaagaaggtt tcttagaaga tttaggtggg tcgcctaaaa aatataagat 26280
taaatgagat agaatgtctt ggttttttca gagaaacttt cttatattga gttttaaata 26340
aactaccgat ataggagagg atgaaagttt tatgttaaaa gtaatgaaaa aagatggtca 26400
tattgaagtt tttgatacga agaaaatcca ggaagcaatt ttagcttctg caaggaaaat 26460
tctttctaat gaggaagagt atgatatgca gcaaaaagct ttaattattg cgaatgaggt 26520
agctcgtttc ttaaattcaa ctgaagatga aaatgcagtt gttatgacat ctaaaattca 26580
taatgttgtt cttgagattc tgtctaagga atgggaagtt gttggagctt cttatggaat 26640
gtatagaaac tatagaaaac aaatggctaa aacattttta aaaagttatg aggaatctga 26700
aactgttctt catgatggag ataaagaaaa tgctaataaa gacagtgact tgaatagtac 26760
aaaacaagcc ttaattgcaa acaataatat gcgtggttat atggaaacat ttgaaatgga 26820
taaagattgg attgaagctc ataaacaagg ttggatacac attcatgact tggcagagcg 26880
ttatttacgc cagcaaaatt gttgtttgtt taacatggca ggtttattag atggtgggtt 26940
ccaattaaat ggaacagttt atgcagagcc taaacatttt gattctgcta ttaatgtagt 27000
aggagatgtt actttatttg cttctgcaca gcaatatggt ggttttacta ttcctgaaat 27060
agatactgtt ttagctaaat atgctgaaaa aagttatcaa tcaaatttaa aatttatttt 27120
agataaattt gggaatatta ctaatgaaga tattatggga acactagaac aaacagccta 27180
tgagatgact gttagagaat tagaacaagg atttcaaggc tttgaaacaa aattaaatac 27240
aattagtaat tctttaggac aaatcccttt tgtaacaatt acttttggtt tggatacaac 27300
tcaatgggga agagaaattt ctaaagctat tttgaatgta cgaattaaag gaattggaga 27360
aaataaatca acagctgtat ttcctaaact atctttctta catagaaagg aaattaatgg 27420
cagtccagaa tctcctaact acgacattaa acaattagga attcaatgtt ctcgattaag 27480
actatatcct gattggttat cactagatag tggaaatctt gcagaggtat atgaaagatc 27540
taatcaagtt gtctctggga tgggttgtag ggccttcctt agcccgttct gggatgaaca 27600
agggaatgaa atttacactg gacgatctaa tattggagct gttacgttga atcttcctaa 27660
aattggctta gagtcaaaag gagactggaa taaatttttt gatctaatag ataaatattc 27720
tgatattgtt tttgctattc acgaagatta ttatactaaa attagtaaaa caaaaggctc 27780
ctctaaccct ctatatttct gtgaaggtgg agcttggaca aaagtgggct atgatgaaga 27840
agttggaaaa atatatgaag cctcaactgc ttcattagga tatattggaa tttatgaaac 27900
gttaaaagca atgaatgttc caaaagaaga atatcttaaa catggaacta aaattgttgc 27960
atatttgaaa aaattaacag aaaaagctac aattaattat aatcatttat atgcacttta 28020
ttcaacgcct aaattatgtg ggcgctaatc tagcaataga ttatgaaaaa actgctaaac 28080
tcttaaaaga ggtgtgggag gaatcctgct aacgggggag gctttaaaat gctaatcccg 28140
tgccaagacg aatttttaca aaaacttgca agaaaggaga gttatttgaa attacctaaa 28200
acagccgtaa aaataaaagg ttccaaagac cattgggttg atataaatgg agacatctat 28260
gcattaaatg gtcgaaacaa ccaaaaaaaa tatctgttca aaaagactca attcactgtg 28320
cacggctata aatattgtgg aataaattat attggcaaag gggtagtgaa taaaagagtt 28380
catagactgg tcgctgaagc ttttattcca aaccctaata actacaatat tgtcggacat 28440
aaaaacaata ttaaatctga taacagggtt gagaacttgt attggacgac tacatcagaa 28500
aataccaaaa aagcatttga tgatggtttg gctaaaaatg ccaagggggc agaagatagt 28560
caaagtattc cagttttaat gttctgtacc aaaaccaata agttgattaa ttcttttggt 28620
agtatttctg aggcttcaag agaaacagga atagataaaa ctacaatttc tagacaggct 28680
cgttataaaa gaccttgtag aaaagagttt tatttccgtt ttcctgatga tgcagatgcg 28740
ctagaaaacc agtccttgat agggatgttt gatttcgact cagatagact tattcgaacc 28800
tttattaata gtggagatgc gcataaagaa acaggtatac caaaaagaac aatttgcgac 28860
caagttaaaa aaaatagaaa accaattaga aaatatttgc aagtatattt tctaaaaata 28920
gaaaattcgt aaggtgtaga gactatcgaa atcctagtag gagagtagag tagcgaaagc 28980
gaaagagcag tcccctttga gaaaaagggt gaaaatatag tccaatcccc taataaatat 29040
cgggaaaccg agggtgtaaa tggcagaaag tttatgctat agattccaga aaattaatcg 29100
taaagattat ggagtaattg aagatgtaac tgatagagag tacattacaa attctttcca 29160
tgttccagta tgggaagatg ttagcgttcc tgaaaaaatt gcttttgagg caccattcca 29220
taaacttgca acaggtgggc gaatttctta taatgaattt gtttatggag tagataattc 29280
tgtactagaa caagcaatta attttgctat ggaaaaagga atgtattatg gagttaacgt 29340
tgttgcagga acttgtaacc aatgtggtta tagtggagat ttccatgata actgtcctaa 29400
atgtggtact catgatatta cagtagtaac gagagtttgt gggtatcttt cctttgatca 29460
gattcatggt gactcacgct ataatcctgg taaacaaaaa gaagttaaag aaagagttaa 29520
acataatttc aaataaaagg agaaatatat gaaagaaaag gaacaagagg ttattgaaaa 29580
gttatatgct tatgtatcag aaatggatgt tgttttagca gaaaagaaag tacaaacaat 29640
ttctttaata ctttttattc ttatcgcagg atactgttta atctttgctt gccctgcatt 29700
tattaatgtt gttgctttaa ctggcttatc ttattttgca tttagtttat ttgcaaattt 29760
aatgcttgaa aaacttttgg ataaagaaat ttcaaaaaat gaagttttat tagaacaaat 29820
tcttaaaaat aaagagaaat aaaaaggaag gaagtttttt aaaatgatgt ttattgcagt 29880
tttttgtggg atttgtatcc tattattaat tggttctgga atgaaagcaa atataggaag 29940
agatactacg agattagaga atatggctta cttaatgttt gccatattct taattttgtt 30000
tatcctaatt ttaattgggg gagcataata tggcttattt acacaatata aaaaaatatg 30060
atatggaaaa cagtggctta aaaggagcct cagtttcttt atggtttaat cattgttcac 30120
accattgtcc aggatgctgg aattcagaaa cttgggaaag aaatgaaaac ttatatgagg 30180
ataaccaaga ggtgatagaa gaggtccttg atggtcttga tggcggccca atgaaattaa 30240
atactctcgc tcttttggga ggagaccctc ttagtcctaa aaatataaaa gatacattag 30300
agattttatc ggcagttaaa acagaaagac cagagacaga agttatttgt tggactggtt 30360
ttacttggga acaagtaact aaaagtaaac tacttaaacc agtattagaa tacttagacg 30420
tattaattga tggtcgtttt atgatagatc gtagaatcga aggtaaaaaa tatggctctg 30480
acaatcaaag atgtattgat gtgaaaaaat ctcttcaatg tgataaaata tatttaatgg 30540
agggatttta atgtttaatt ttaataaaaa aacagaaaaa agttctgtaa aaaaatatcg 30600
taaaaaacct gttgaggtag aggtatggct ttttaacaga gaaaatttag aaacagtaga 30660
aagttgggta cgtaagtatt cagataaaat gactttattt tctcaatatg gtgggggaaa 30720
aatttggata gaaataaaaa ctttagaagg tgtaatgaaa gcttctgaag gagattatat 30780
tataaaagga atcaatggag aattatatcc ttgcaaacca gatattttta ttaaaactta 30840
tgaagaggtg acaaattaat gtatgaaaca atagttatag gtggcggacc aggagcaatg 30900
tctgctgtcc tttatttatc tcggcttggt ttaaaaactg catggatcta tggttatggt 30960
tttgggggac aaattcaaaa tacagaagtt gtagataatt atcttggaaa ggggaaaatt 31020
tatgccccaa tcttggtaaa agatatgtac tctcatgtag aagacttaga acatattaca 31080
caaatttttg gtatggttga aaatgttaat aaaattgatg attcaacttt tatagttact 31140
accgatatgg gagaaaaaat tagtggtaat actgtattag ttgcaactgg agcttctcct 31200
agaaaacttg gagttaaagg agaagaagat ttcgctggtt ttggcgtatc ttattgtgct 31260
atttgtgatg ctcctttgtt taaagataaa gaagtagcaa ttgttggtgg tggacaaact 31320
gctttagaag atgcacaaat cctatctcgt catgcaaaaa atgtatattt aattcataga 31380
cgacaagaat ttagagcaac aaatgccgaa gtaaaacaag caaaaaatac tccaaatatc 31440
cattttctct tggatacaca agttacttcc attatgggaa aagacgacgt tgattttatt 31500
gttattaatg aaaagggaat tggtcacaga actttatctg tggatggtat ttttatagct 31560
ataggacaag ttcctcaaac tgatttttta actgaaaact ttgattatat tttacgagat 31620
ggttatgtag aaacgatgag aaataataag gtagaagatt taggcatctt tgccattggg 31680
gatgtagttt atgggaataa taaacaaatt gctattgctg taggagaagg tgcgaatgcc 31740
gcaatagaaa ttaataaata tttatcagac cctaattttt gattttttat gtataaaatg 31800
ttaatataaa tatataacaa aataggagga caaaattatg actgtatatg ctatgtcaga 31860
tatccatgga aattttcaag ccttagaaaa agctttagat ttcttattta ataaaacaaa 31920
aatttctatt ggtgaggata aacttatttt tcttggagat tatattgatc gttctcctga 31980
tggatattct gttttaaaga ctatttatga cttacaacaa aaacatggaa aagaaaatat 32040
tattgtttta atggggaatc atgatgaaat gtttttggag tggttaaaaa atccttctaa 32100
tactcttcat ttaattaatg ataagccatt aactactgtc aaaagtttta taaaacctct 32160
taacaaggag tggaacttaa tttttgacgg tgtagatgct atttatgaca taagtgatcc 32220
taataatcaa attaaagtta cacaagaagt tgttgataca attaaaacag aatacaaaga 32280
attattagat tggtatcaaa atttagatta tttttatgaa catgggaatg ctttgtttgt 32340
tcatgccggt tttgaagaag agtcaagtgg gcattggaca gattcctcta aagaagaaat 32400
gacttggaaa tacccagctt ctcttggtta tacgccgtgg aataaagaaa ttgtagcagg 32460
tcatataatg acgagagagt tgcatccaga aggagttccc caagagaaag aagattcaat 32520
ttatagaaat aaggatcata tttttattga cggggctgcg ccgatcacaa atcatattaa 32580
tattttggct tatgatgaaa atggttatct atactatgat gctgagacag gagaaatttt 32640
accagaataa cctaagcttt ttattgtcat tattaatttt ccctttttat tatctttagc 32700
agagataaat aaagagagga gaattaatat gagaatcaat gcagataaaa taagagaata 32760
tagagaagag catggaatta gtatcgatga gatggctgaa attcttaata tagatggaga 32820
agcactttat gaatacgaaa gtggagttcc atggtttgaa gaagatgcct taactatttt 32880
tacgattaat aatatttgtg ataatttaga ttttattgct atagatgttg aggaattatt 32940
tgaagaatat aatatttaat tttataaaat tcaactattg gatttccttt agttgaattt 33000
ttttatttaa aattatataa tatatatgta agttaattaa gaaaggaagt tgcttaatga 33060
aagaagaaat tttgaacatc ctattagttg atttgaaaga agatttagat agagaattaa 33120
ttgtatcagt agacttactt taggaggcga aaagtataaa aaagattatt aagattcatg 33180
tagatggaag ctataaacaa aaagttaatc ctaacgtagc tggttggggc ttttgtgttg 33240
aagcagagga gcaagaagtt ttatatgctg cttccggtat tgtaaacaat ccagtttcta 33300
gacagattga tggagaaatt caagccgcta aagaagctat taattggtgc cttgaaaatg 33360
ttatagataa agtagataca aaaattgaaa tatatcacga ttatgaaggc ttaggaaaat 33420
gggctgacaa tctttggaag acaaataaac ccttaactac agaatataag ctttttgttt 33480
ctaacgctcg attctcagga cttaaagttt attttatatg ggaaaaaggt cataataata 33540
atttttttaa tgaaattgca gatgagttag caacttctgc cgttgaagat tctgttagtt 33600
aaaatatcca acagaaaata atattctata agtagaataa ataaaaatag gaggttttaa 33660
aatgaataaa gatttattag taaggggtgt aaaaagtaca gtaaaaacag tagaaacaaa 33720
attaaataga aaagttcatt ctgtatattt gacaggtagc gctctttatg gagtttctac 33780
tcctgaaagt gattttgatt ttaaggtcta tgtatacccc accttttcag atttgtgctt 33840
taacgaaaag ctttctaaag aggtggctat taatgaaaac aatgtagaac atgtttctgt 33900
aagagatgtt cgattccaat atgatgagct aaataaattg tccttcaata gcgcccattt 33960
acttcatcct cctcttttgg gaaaaagatt atttacagaa gaacaattaa cacaagtttt 34020
agaagagaga aaagataatt ttctttttag tcttgctggg gtctctttat cagagtctaa 34080
aaatgaagat tcagggaaaa aactttcaag aatgttattg ttagaaaata tgtttactgc 34140
tgttttagag gataaattta ctctaaatta tttctttgat aaagattcct ctaaagaagt 34200
attggttaga gaaaatcttc atagatatac agactttgct aaacttactc ctgaagaatt 34260
gatgttgaca gccaaagact ttaaaaaaca atataaggtt gactataaaa aattagagaa 34320
tgttttaaaa aatcaattat tagaaacagt aaaaacattt tacaatgtag gaaaggaagt 34380
atattaatgt ttaacgtatt aattacaaaa gatatggtaa tgaatgggat tacaatcaaa 34440
aatgttcctg ttaaacaatt agaaggtaag gatgctcctg ggattacaaa aggggttgct 34500
agtaaaattc aagatttagt ttggaaagct aacgcactta aagttgatac aatagatttt 34560
agttataatt tagggaaaga ataggagaag agatttttat gtttcttgat tatgatgaag 34620
gtttagtaga agattatgta gacaaaaata ttgttcagcc tgtattaaaa ttaattgaac 34680
agacaataaa agatgctggt aaagatcctt cagaatggga ttttttaaat ctatctattt 34740
ctttagatga tactgaatta aaatatatta atctttatgg ggaaaacaaa ttttattttc 34800
gatttatgga agaaaatatc catgtatata ttcacaacaa agaattgtat atcacaaaaa 34860
agagaaaatc tggaattcag ctttctgact acttaaacga agaaaatatg gagctaacag 34920
caaatcaaat tagtagtttt ttagaacaat actttaagga ggaagaataa ttgaatacat 34980
taaaaatgga tcactttgtt gcatctagta tttctgaaat cctagataat ggagttaatt 35040
ctttaggagc tcgtcctaaa tacgcctctg atgggaaaac cgccaatagt aaatatataa 35100
cagatgtatt tatcaaattt tatttagaca agggagagtt gcccattagt agattgcgtc 35160
ctgtatatac tggattagct agacaggaac ttttttggat atatcaagat caaacatctg 35220
atttgcagcc attaagagat agaggagtcc attggtggga agattgggct ttagaggatg 35280
gaactattgg acaacgttat ggagcaacag ttaatcgcta taatctaatt gatagattaa 35340
tagaaggact agaaaagaac ccatataatc gtagaaatat tattaattta tggcaatata 35400
aagacttaga tgaaacagaa ggtttaatgc catgtgcttt tcaaactatt tgggatgtta 35460
gagaagttaa tggagaaatg tttttggata tgagtttaat tcaacgcagt tcagattttc 35520
tcatagccgg catgggtatc aatcaaatcc aatatgtagc attacaaatg atggtggcta 35580
aacattttgg gtggaaggta ggaacttttt cttggcatgt aatgaacttg catatttatg 35640
atagatattt tgctcaagct caagaattag ttgctagatt tgaaaatatg aaccaagagg 35700
aacaaaaaga aattgagttt tacttggacg ttcctgataa aactaatttt tatgatataa 35760
aaccaagcga ttttgtacta aagggctatt cctctgtggg agatcagatg aaatttgata 35820
tggcaattta ataataaatt aagacacctt aaatggtgtc ttttttttgt actttttagc 35880
tataggattt taacgtattt gagctaggaa attctcaaaa aataaaagga aggtgtaaaa 35940
tatgtttaaa gaaaaagatt tacttattcc aattggcgta tttacagtcg gggagtctaa 36000
agaagattat atcgaaatgg acccatatga aaaaggcact gttgacaagt taaaagaata 36060
taatgaaaat ggcgtagtag aaatgaccgc agaaggtgaa aagaaagatt ttgatggata 36120
ttcaaaagga gatttcttct cttttggaga taagggattt ccagtagttc gaagcaatga 36180
aatttttact aaactagatg ttaatggaca attgctatca ttccccaatc ataaacttat 36240
ggaaggtgat aaataatgac tcgtttttat aaaggaatcg ctggtcgtcg aggagctaat 36300
ccatcaggag tagttattca caatgatgca ggctctgttt atgctaatgc tgcattctat 36360
cgtggatggt taccttctca tgatgcagaa aatggttttg ctcattatta tgtagctagc 36420
gatggaacat tccaagcaga agatgaaatg aatatggcat ggcatactgc aaattcaact 36480
ggtaatgcat attatatcgg tattgaagca tgtcaatcaa tgggaccaga aaatattttt 36540
cgacaaaatg aagaaaattc tattaaatta gcagcccaaa tcttaaagag atatggttta 36600
caacctaata gaaatactgt gaaattgcat aaacaatttt caccaacttc ttgtcctcac 36660
cgctctgttg cactacatgg agatggatat gtaatgcaag attattttat tgctcgtatt 36720
aaatcttata tgggttctaa accagctcca gcgccagctc cagcaccaag tactggaact 36780
agaaaatata atattgacct agttaatatg aattcaaaag ctttccaaat caaaggttgg 36840
tttaccccag ctaaggctac aaaaggtcaa gatatttggg tttatattat gaaaaaaggt 36900
ggaccagaaa ttgcccgctt taaagcgaaa aaaattcaac gtccagacgt tcaaaaagca 36960
gtttcaaatc ctaacggagc agatgttggt ttccaagtag atgctcttac gccagaaggt 37020
gttctaggaa aagattttga tttattactt cgttacaaca acgataacaa agaagaaatt 37080
cgcactaaag agcattggaa agctcctgca ttaattaatg aaggatacct agataaagtt 37140
gctggagatg ctaaaggtgt tacattcgcc ggatggcatt taaatacacg tcaaaaagat 37200
ggatttaaac attatctatt tgtaactgat gcaaaaactg gaaaagaata tgtacgattc 37260
gatattacag gagggtctta cttagcttct ccagatatca ctaagaaata tggtccagaa 37320
atcgctcaac gtggtaactg tcgcttccat aattggtgcg cattagcagc aaatcatcca 37380
gccagaggta aaactgttaa cattattagc cgttatgctc ctgcaaaaga aattgataca 37440
aaaacttcta cagacaaact gtggggaact tatagactat aaaaataaga ttaaaaatac 37500
ccttagaaat aagggtattt ttttgctttt tatacataaa tttgttataa taataacaaa 37560
tagaataaaa aaaaggaagt gtttttattg atttatgctg tagcagcaat tggaccaaat 37620
ggagaattag ggttaaataa taaattaatt taccattttt cagaagatat gaaaagattt 37680
aaaactttaa cttggaatag aaatatttat atggggtata aaacttggga atcactgcca 37740
gtagaagcat tacccaatag gatgaataca gtagtgctgg atatggaaag aggaatatca 37800
aaaaaactcc agacagccat gaaaaacaat gacaatttaa aagttataga tgagtccatg 37860
tttcttgctc tcttggagat tcattcatta tcctcagatg ttattgtagt tattggtgga 37920
ggaaggttat atgcacaaac tcaatattat tggagtagat tgtatttaac aagattttat 37980
gaaaagagac aagcagatac gtattttcct gaaatagatt ataataatta taccatgaag 38040
agtttccaaa agcaagaaga ttgtgaattt attgattttt atcgtataaa atgatataat 38100
taatatatac ttaaaaagga gataataaaa tggaaaaaat tgtagaatat attttagtta 38160
ataaggaatt aaatatgagc gttggtaaaa tcgctggtca agttgctcat gtacaaacag 38220
ttattgataa taaaattttt gaattagttc tatcagaaga gattcttgac gaagatagta 38280
tggatagttt tgctaaagaa aaagaattaa ccaataatta ttatgattgg ctttattctg 38340
gatctcaaac aaaaattatc ttacgagcca aagaaaaaga tttgcttaag gcaattgata 38400
tgggagcagt atatattaga gataatggct taactgagat tccttcaggt tcactaaccg 38460
ttgtaggttt ctttccacaa ccgaaagaca atctagtaga tttcaccaaa aaatttcaat 38520
tgttataaga ggagattaat ataatgaaaa ttattggata tattttaatg gaattaggca 38580
gaagtcgccc atcctctata ggtgggtgat gaatgccgtt cggtatgagg gttaccgttg 38640
gtaactcgaa gaccgaaaag ataaatgcta taattagttt gattccaagc atgatggtgc 38700
aattccagtg tgaaggcgct caagtgaaag atattgagtt agcgccacaa gtaaaactgt 38760
aagacttgaa gacattcgtg acgatgcgag tgtaacaatg attatgatta gagtgaaaaa 38820
caaactgaat ctgtcataac gttgtgtggt tagtatttcg accgacgata aaaataaatc 38880
aaaaaaaccg taggaactac ggggatagct tggtaaataa gagaaaccgc tgttagtgaa 38940
gaaataagct atcaagtatg ctctattccc aagaagctcc cacttcaagt gttaagaacc 39000
gttaggttta gctaagtgga gagtagttca ctggaaagaa cttcctataa ccagactttt 39060
gtaaaactcg aatttaattt aatttgattt tttcagaata agatgatata atattattat 39120
aataaatgat aaaaaggaga aaaacattat gaagaaaaca aaattttatg gagtcgtctc 39180
tacaagtaaa aaagctcgtg aggtagtgcg aacaaaagat tcaaaaggac gttggacttc 39240
tgaggttcaa gaaatttctc gtccaattga tatcttagta acttctgatt ttactaatcg 39300
tattgatgct ttaaatgata ttgaagcaca agcagctaaa ttaggtacac taaaatttac 39360
tagtgctttt aaataacata taatattgaa agggaatttt tataattccc tttttacata 39420
gaaatataaa aataaaggag agtggagttc catgaaaatt aaaccttctc ataaaatgaa 39480
attggatgaa gtaggagatt acctacaaaa ggtttctcgt ggagtaggaa ctattaagcc 39540
aaaaaagggt aaaggctcgt ataaaagaaa gcctaaacat aaagggaagt gggattaatg 39600
gataaagata taaaatatac gatctcaagt ggaggcgaaa caattggcta ttggacgcaa 39660
gaagaatatg aaatctggat ggcgaagatt catggtactc acgaatactc tgaaggagaa 39720
caaagaaaaa ttgaagaagt tagaaaaaga ttaaataata tatctatgat aaaaaatagt 39780
gatggtagtt atagatttat taaagaggag gaaaacagtg tcaattaatt tattatatgg 39840
taaaccggta gcagattcaa tttataaaga tattcattat ccaaataaaa aagttttgca 39900
tattttccag gttggagatc tagaggaatc taaccgctat atcaaaaata agattaaaaa 39960
ggctgaatct ttaggtattc caactcagct acacaaggct gaaactaaag aaaaggtcga 40020
taaaatttta aaagaacttg tatctttaac aaagattcct aatcgagata aagtatctgg 40080
tatatttgtt caacttcctt ttgaatttga tcgccttatg gaagatacat ttttgcgtgt 40140
aattccccca gaatttgatg ttgatggttt aacacattat aatttaggac gtctactaga 40200
tggaagcaga actgacctaa attttgtccc agcaacagcg catggggtag tagatatgct 40260
aaaatattat aacatcccaa tagagggaaa aactgtaggt attattggtc gttccaattt 40320
agtcggaaag ccacttattc ctcttctttt ggaagaaaat gcaactgtca ttagtatgaa 40380
ttcctatact gataaaaaga atttaatttc tctcagcaaa caatgtgata tattggtggt 40440
agcaattgga aaagctaact ttatagacag caatttcatt aaagataatg ctactgttat 40500
agatgttggt attaattttg atgaatctgg gaagttagtt ggagatgtag actctaattc 40560
tttgaaaaaa gaaggttgga atggcaatct ttctccagta ccaggtggag ttggaccttt 40620
gacaatcgct aatttaatga gaaatgtaaa tataggagcg tggagataat gatggattat 40680
tttagtgtag agcaagttaa acatatttta ttattaaaag atttacaggg gtatactatt 40740
gatgctattt ttcaagatga tactccagag cagagatata gtaacttaat caaagtattt 40800
ttgggattag aaaatgtttt tatttgccaa aaaaaagatt atcttactaa gggagattta 40860
tattccgata attctatggt agaatctatt gccaaaaaaa ttaaagaatg cctgtaaaag 40920
ggcatttttt aattgaattt attaatttaa aatgatataa ttaattataa agttaaataa 40980
ggaggtaaaa atgatagagt tagcctctca tattgtagat ttaagtttag aacataaaaa 41040
atatatttgt catttacagt tacaaaaaat aacgtactat actgtattgc aggggttaaa 41100
attaaattta atagataaac acactctcga agaattatat aaatataagt ctgatagatt 41160
tacaccatca agatatggtc ctcgatccga agctatattt cttcgatact gtgcatttgg 41220
ggcggaaaga atttttacta attcctttag cagttcatat ttaagaaata tggatttctc 41280
ccacttgaac cctattattc ttcctctttt ggaagaacag acaatggatt tatgtaggaa 41340
aagtatgaaa aatcctattt ttgaagaacg gtttaaagat aataaagaat ttagtattga 41400
agatatattt gaacttagtg aaaaatattc agatttgaaa taaaaaatat aaaatgatat 41460
aattaattat aaagttaaat aaggaggaaa ttttaaatga aaaaaagttt agtaggattc 41520
tcaattgttg caatgtttgg tttaggttta gtaggatgta ctaaaggaga agttcctgat 41580
ggacaatgga aaagcgaaga ttctactgaa cagacagtag aaagtagcac agtagaatcg 41640
tctgaacaaa aagaacctta taaaaaagat gaggttcaat tatctacctt agaacaacaa 41700
gttttagatg cttttcaaca aagtttccaa tcaacaggac cggttcgttt tgattctgta 41760
aaaaaatatt atattattac accaacagat cctcaattta cgcaagaaat ggcagctatc 41820
atggatggca cattaagttt agacgtatgg actaatttgg ttcaaaatgt tcaacaaaca 41880
tctttaggtt tacaagatac tcttggtagt ggatatacaa ttattattga aaatccattt 41940
gaaacaggtc agatgttttt ggctgtaagt gatggagaag ttgttttcga tggtttgaca 42000
gagtatatga ctggtcaaaa ctcataactt gaaaaaatat gaataacatg ttataatatt 42060
tatataagat aaagttactt gagtggtcgc aaaaaggaaa gacgcatggt ttaatcttcc 42120
atgagacgtt ggttcgagtc caacctcaag aatatgagga ttcgctatcc cttcacctta 42180
tgcatgacga tgcagtgtaa gttcgaatcc tactatctca gttaaacagg gacttgagct 42240
aattcatttt agccagtcct tatcccgaaa gggaaaaata atttgacatt ttaagcataa 42300
tatgttataa ttattatata ataaagataa gaaatatgaa acggcttgtt ggtcaagaag 42360
ttaagacgct cgactttcac tcgggaatca caggtgcaaa tcctgtacaa gtcattaatt 42420
ttattaaaag gaggagtaca atgtcaacta tagttgggaa ttttagttta gattatccaa 42480
gaactattag tggtaaacag aaaattgaag ctttagaaaa gatcaatgaa atgggagata 42540
aaatcattga tcaattcttc tctagtcaag agacaaatgc tccaactttt tttatcaata 42600
accgacttac tagaacatat ggtagatatt tccctagtga aaataaaatc gaaatgtctg 42660
gtcagtttac aaagatcgct ctatatcttg caaaagacga atctttattt gaaaaagttt 42720
tgaaacacga acttgctcac tggtacttac ataaaagtgg gcgtaaatac agcgatggag 42780
agcctgaatt tgaaaaattg ttgtcttata ttgattcact ttcgtcagga gcaactaata 42840
aaaagctaca attagctcca acaacacctc ttttatcatt taaagttcat tctgaatgtg 42900
ataagtgcgg agcttctaat ttttcaaaca gacgattaaa taatcgttat acccatgttg 42960
attgtggtgg cttgctagtt gataaagaat tggttgtagt taaatcttaa aagatatttg 43020
aaaaaaatct ttcaaaatgt tataattaat atgtaaaaag aaataaaaaa acttatttta 43080
aaaggagaga ttcatcatgg aaaaacaaac taaagcagat atgtatcgta gcgcagcaaa 43140
attgttggaa gtaaatgctc ctgaatatgc agaaatgtta ttggaagatg ctcaaagaat 43200
tgaagctcgt aacgcaagtc gtcgaaacgt tgatactaag gttcaaaaag aaaataaaca 43260
catcgctgct ttagtaattg agtttttcca caatgacgct gaagatggaa tcgcttatga 43320
cagtggcgaa attgcaaatg gagttggaat cgaagtttct cctcaaaaaa tgtctgcaat 43380
tatgcgttta gttggagacg aagtagataa agtaggtcaa gctacgaaca ataaagatca 43440
tgttggatat aaaaagaaag gaactgaatt agtttctgat gaaaagtagg acaaaatgtc 43500
ttaattaaat atccccatat tttattgggg atacaccagg gtataggaga atttggctaa 43560
tccgctgcat ttgggatgca gagattgttg gttcaaatcc agctaccctg attgaaacaa 43620
cgtgttagaa cgttgggcgt gaaggaattt attccaacac gtttaaacat tcacctatga 43680
tgaaatggta tcatgattga ctgttaatca attcttgcag gttcgaatcc tgctgggtga 43740
gttaaagaat cttacagcaa atattaatac ttttaataat atttgatgag aaaaataagg 43800
tctaggttcg acccctagta taagttcggt acaacttata tggtgtaatg gtagcacaca 43860
aaaagcagat tcttgttttt ggggaaggta cctccccagt atttggagga ttatgcaaat 43920
tggtgaagca agtggtctgt aaaaccatga cgtaagatac attgggggtt cgaatccctt 43980
gtcctccatt ttggcgctat ggtcaagcgg ttaagacact ggtctttcta accagaatcc 44040
cgagttcgaa tctcggtagc gtcataaaga acgatacagc aaaaccttat tcaaatatta 44100
cagaagagat tatgtaagga gccgtagata ccaaccgaaa aatctacgag ttcaactatg 44160
gttggcgttt gagttttttc taggtgcttt tcttgagttt acgttagaac tcgaaaaagg 44220
tctaaacttc gttcttgata aataaacaca actttccttt cttcctgtcc atgtcactgg 44280
acaggtaaca cgggtatggt gggattggca gacacatcag acttaagatc tgacgagaag 44340
tatctctctc atgcaggttc gactcctgct atccgtataa agaacctaac agcaatcaca 44400
tttaatggga taatagtata tctaataata tataggttct tgttttttat aatggctact 44460
gcccatcgca acctacatac ggttcgatga tagtcttccc tctgctaagg gtttatcttt 44520
acctgtgtgt agtagcttaa aagaccaaat taaacaggta atccggaaag tagctcagct 44580
tggtagagcg caggctttgg gagtctgatg tcgcaggttc aagtcctgtc tttccgattt 44640
gcgtaagtta atcattaaaa ttagccccta gtcaaatttc cactttggcg gctaggttga 44700
ggcgcacaat aggcataaag acacctcgta aaagggcaag cgcagtgtcc ttacccaaat 44760
aaaacagcgg cagcctttac gctggtttcg tataatggct attacagttg acttgtaatc 44820
ttcaaatggg agttcgattc tctcaaccag catttataaa tgaatgaggc attggttagg 44880
tctaaaatag atatagggat atttagttat ctacgggtgc tagatattgt gtaattcatt 44940
ttatttttcg atgattcgtt caaatggata ggacgctaga ctacgaatct agtaatagag 45000
gttcaagtcc tctatcgtcg gtagtacaag gaatgatatt tcgcttatac gaaacgttaa 45060
gagattctca cactgacgtc ccaatagaga aggatttgaa tatcttcctt ctcttggttt 45120
tcaatactat taggatttat tagagcctgc cagtcaggct cttaatattg tcaaaaataa 45180
ggaaaagtta gaggagatgg ttatgataat tacattagcc ggagttattg gtgtaggtaa 45240
atcatcaatg gcagaaatat tagcaaatct tttaaataca aaagcagttt atgaaccggt 45300
agaggaaaat ccaatgcttg aattgttcta ccaagataaa gcaaagtatg gactactttt 45360
ccaaatagat atgttgtcta aacgcttcga aatgattcaa gaagctatga gtgtagataa 45420
cggtatttta gaccgttcta tttttgaaga cagtatcttc ttagaccaac tagtacaaga 45480
gggtcatgtc acagaaatgg aacagggagt ttatcaccga ttgcttaatc gtatgttaaa 45540
agaattagaa ccattaccta aaaagactcc cgatttaatg attgtattaa attgttcttt 45600
tgaagaagaa atcaaacgaa tcaatgcacg tgctcgtgag tttgagaaag tagaagaggg 45660
tactgaatta tacgaatact ttaaacacca tcacgagaac tatcaaaatt ggttacaaaa 45720
agatatggga ttccctaaaa ttgttttaga tgtaacagat aaagactttg tgaatgataa 45780
aggagaccgt gtttacttgt taacaattat tttgagtaag ttgtgtgaag tcggggcact 45840
atctactgta gatacggtta aatgtttatg tgagttaaat ggcttacctt ggtgtaaaga 45900
ccacgctaca caagttgcat tgaagctata caatagatta gagggtaaac tacctttcca 45960
tgaattaagc aagtttactg acaatcaaga cttatacaca ctagagaaag ctgtttaatg 46020
gaggaaaaat aacaaatgga caagttaaaa aagttttgga aggataacaa agaaaatatt 46080
gaaaaattat tcacttacga atattataaa gatggtttaa ctggttggaa caaatcagct 46140
cgtgtattgt ggtttgtcgg aatggcagtc caagtattta ccggtattgt tctacctatg 46200
ctacaaggtc aagggttaac aatgacaggg tttactgcta caattgcagg aattattgga 46260
tttacatgta ctgtagcaat tacaatgggt aaatcaatta atggtatttt aggattcatt 46320
tctgctattt tattaatcgg tgtagcaact gtaacaggta actatagtga tattattatg 46380
caaactgctt atattgtttt gttagacatt cctatcatct tctctaaaca atggaatgag 46440
ggtttgaaac ctcgtaaaat gcaacctgta cacatgctta aaacattagg tcttattgtt 46500
gttttctggg ttgctttata cttcttagat acagttgttt tacactcacc gcaggctttc 46560
ttagatgcaa caagtgcaat gatcggttta gttggagctg tactgtgtgt gaaaggcttt 46620
agagcgcaat attacttctg gacttttcaa ggtctaatgt cggtagctct atggattcaa 46680
acagctttac atggacatgc ggtttatgta ctaatgctaa cttacatgtt atatctggca 46740
aatgatgtat tagcattcac aaactctaaa tggtttaaaa atggtaaaat caaagaaatt 46800
aaataattta ttagacagat aggagagctt gaacaatatg aagaaaagat tgaataaact 46860
ataaatatct tataaaggag gtatttatag tatgagtaga agcagaaaaa aacaaccata 46920
ttcaagatat gtttgtatga agaattcttc tgtcagaaaa tccaagaaac aagtaaatcg 46980
tctttatcga agaagaatga aacaaggtcg atatgatgaa gatgccaaaa ttccaagttt 47040
atataaaaga catgtagatt tggattggga ttatgaaatg ataaaaggat attttcccaa 47100
agaaaagtat cctgattttt atgaaaaact tatgagaaaa taaaactccc taaataaggg 47160
agttttttat ttgaaaaaat taatttaaaa tgatataatt aattataagg ttaaataaag 47220
gagattttaa aaatgaatga aagagaaaga atatttcata aagctaaaaa tatcactgcc 47280
aaaactgaat taattagagg cgtagtacaa aatccaatgc tccccgaaga agtagattta 47340
gaagaattca aaaaagaaat tcagcgtatc aaacgagaat taacagatta tcaaaatgaa 47400
gttctcttat attttgcctc tattggggat gaagagaaag aaagaattaa gcaagaacag 47460
ttagaattat ctgaatactg ggaacaaaag agggaaacta tactatgaaa gtatttgtag 47520
atgatttaag gaagtgtcct gaaagatatg aattatttag gagcgcagaa gattttcttg 47580
attggagaaa gaaaaataat gatgtagaaa ttgatatttt ggcattggat catgacctag 47640
gagaaaactg tttgaatggg tacgaattag ttcaagaatt agtaaaatct actagaatgg 47700
acaatattaa aactattatc tttcacacag ataatttaat tggtatgaaa aatatgtatt 47760
attatttaag taatgcccaa aagcatggga ttattagtaa aaatattgta ataaacccaa 47820
ataaatataa ttgtttagat ggtaagttta ctcatagtct atatcgtatt attaaataat 47880
ttgaaattat taatataata tattataatt atattataag ataattaatc atatttaata 47940
ttattaatga gattaaaaag ttgttgaaga agaaaatttt gaagatgaag aaagttggtt 48000
agataaatga aagtagggga cactgttctt attcttaaag actttgaaga ttttgcttgt 48060
aaaggatgta ttggagtaat tgaagaaata aatatagtct tcaataaagt acgttttgtt 48120
tcaaaagaag gcactgaaat gatttgtcct ttttttgacg aagaactgga ggtaatctaa 48180
tggtatttgt atttttattg ttaaatggag gagttatatt aggaacgatt ggtttaattt 48240
ttcttattat tgctacaatt ttatccatta agccaagcac tagagaaaaa tatattgata 48300
taattattaa attttattat gttgcaggta tactttatat tgtttcagcc tttttctctt 48360
ttgaagtttt tgctatattc ttaaaagttt tggttggatt aatatgctta tataatgttt 48420
atttaatcaa aaaaaataaa aattgacttt tttagcataa catgttataa tatttatata 48480
agttaggaag aaaaaacttc ctaatatgtc gctatagtgt aatggatagc acaagaaact 48540
tctaatttct aagtttaggt tcgaatccta atagcgatgt tcacagtaga atagcttatg 48600
tttggttaaa gcactcacct tataagtgag agagcgtggg ttcgaacccc acttctacta 48660
taaactatac aaagtaagga agctctttgt aattaggaca aaatgtctta aaagacatgt 48720
aaattatttt aaagacttat acaggtgcga aattaattca acaggtagaa ttatttagat 48780
gggttcaaat cccatatttc gcttaggtaa agaatcttac agcaaatatc atatgtttaa 48840
taggctaatt caaatatatt atataagatt cttgaagtta tttttagccg attaagagat 48900
aaaggagata aataactatg acatttttag ataatttgaa agaggaagca acagttggac 48960
gcacttttaa tggtgcaact acctatacta cttcactaaa tgctaatgtt gacttttttg 49020
cattaggtgg atctatgcga taccaaagtg ttggagataa ggtttcatta tttgaaaaag 49080
catataatga agatagagct gttgcattga gaaatctagt ttatatgcga gatattcgta 49140
atggtggact aggtgaaaga gatatgttcc acgcaggaat ttggttctta gctaaaaaga 49200
aagatgaaaa agcacttcat gttatcatga ataatgtagc tgattttggt cgttgggatg 49260
atctattttt cattatgaaa caagatgaaa aattgtttga ttatggacta attatcatta 49320
aaactcagct tctgaaagat atggataata tgcgaaaggg caaagaaatt tctttattag 49380
gaaaatggtt gcctaatatc aatgctaaaa acgaagaacg aagagctttt ggtcttagag 49440
ttgctaatgc tttaggatat actaaaccta gtgattataa ggtttaccga aagatgttgg 49500
ttaatctaag agaaaaatta gatttagtag aagtaaaatt ggctgctaaa gattatgatt 49560
caattgattt ttctaagcta ccttctcgag caggatttaa gtatcgctca gcattttggc 49620
gccatatttc agatcgttat tctgaatttt tggatgctgt aaataatggt gaagctacaa 49680
tgaatggaaa tttggtaatg ccagatgaaa ttattaaagc ttatggatat cgtagttgta 49740
tttcttatga agaacaacct gaattagaag ctgcatggaa atctctaaaa gatactgtta 49800
agggttctga cgagaatgta attgtagttg cagatacttc tgcttctatg tggggtaaac 49860
catgggaagt agctgaaggc ttggcaattt atactgctga acgcttggaa ggaccattca 49920
agaataattt tatcactttc tctgaatgcc cacaattagt aactttacca aatgattgct 49980
ccttacgaga taaaatgaat gaatattctc gtcattctat tatcgaaaac acaaatattg 50040
aagcagtatt taatcttatc ttagatactg ctatcaagaa taacactcca aaagaagaag 50100
ttccatctaa gattatcatt atttcagata tggaatttga ttttcaacga ggaaatggcg 50160
ttacacattt caaacttgca aaatctcgtt ttgaggacgc tggttatgaa atgccagatg 50220
tagtcttttg gaatgtagaa gctagattag gaaacttgcc tgttcgttat aatgaacaag 50280
gagccgcatt agtatctgga ttcagcacaa atattctaac ttccatctta aatgggaaac 50340
tagaaactcc agaagctatg atgttagaaa cgttatctaa tccagcattt gacttcattg 50400
atgaagccat ctaaaatgcc cccttttcta cctcttaatt gaggtagtta cgcttcttta 50460
gctcagtagg tagtagcgcc agtctgaaga actggaggtc cctggttcga ttccaggagg 50520
aagcattaat ccagcccagg aaagtgccaa cactatattc gctctcttgg gctttttcat 50580
atttgaaaaa atatattaat catgttataa ttaattataa agttaattaa gaactttaaa 50640
aatgtccctg tcgccaagag gcttaaggct atggattgca aacccataat acgtgagttc 50700
gaatctcacc agggacttat ttcttatgaa agaaggggaa aaacttgact aaatttatta 50760
cgagtgattg gcatttcttc cataataatg cttgtggtcc agaaggattc atttctacta 50820
gaaaaaagtt ttcctctgta gaagagatga acgataatat tattaaaact attaatcaaa 50880
aggttggtag agatgatact attattcatt taggagatat tggttttggt aaacctaaaa 50940
aattgtttga aacattagaa aagatcaatg gacaaattat tttaattaag ggaaatcatg 51000
atagttcaaa attatttaag tatattgtaa ataataatta tcattatcca tatagtaatc 51060
ctaaaaaacg taaacaatct cctgacagag ttaaattttt agttgaagaa gttggtttaa 51120
gggaaaaaat gaatggtaaa gtttactatt taactcacta tccatttcaa ttaggagagc 51180
aacgtaaaaa tatgcgttca atttgtgggc atattcatga gcaaattgcc cctgacgcta 51240
atatgattaa tgtaggcatt gattctcctg aaattacttc aaagatttct aactttggag 51300
aacctcttct tctggaagat gcaatagaat tagttgataa aaaatgggaa aaatggtata 51360
atactataag atttttggga agttaatctt cccttttacg gagctatgac tgagaggctg 51420
aaggtgacgc actgctaatg cgttagtcga cataaagttg gctcatgggt tcgaatccca 51480
ttagctcctt ttattaaaaa tagggggttt ttatatgttc ggtgctaaat tagcattttt 51540
tctatatgtt gtcgcaataa ttacatttat ggttttactt gctccaattg tattatatct 51600
aatttggaat tttgtagtag caatagcatt tccaggacta tttacattaa cttttttcca 51660
atgttttagt ataacattat tgcttacttt tataaaagca attttcatta ataaaaaatc 51720
taacgactaa aaattaaatt taaaggagaa tgatataaat atggcgaaaa aacaaaacac 51780
tactaaagaa ccagttgaat tgacacaaaa gattgatttt actgaatggt tgaaaaaaca 51840
ggaagcaacc tttagaagta aagtttataa agaacataaa aaatctaagc ccgttaaata 51900
gggctttttt tcttgacttt atttgagata tatgttataa tataagtata ataaaaataa 51960
ggaggagtat cacattgtca gataaaacta atacagtaga cgttgaatat ttaacgtatt 52020
ggaaactaac tccaacagaa aaagatagat taaaaacaga ttatggtatt tctagaaata 52080
aagctaaata tgatattgat aaacatactg tcgtaccaca gccagtaaat gcagaagatt 52140
tagatttctt ccctggtgaa tttgtagctt cttttgttat ctatgaagga caaaattatc 52200
cagtattttt aaaaattaat gatcctaatg aatacgttga tttaccaatt gaatcaacac 52260
caaaaggaga tgagctaatt gattaatgac aaatacgcct ttcaacaaga aatgaatgcc 52320
cgcacaaaat tagtatttaa aagtcctatg gatggaatta atttctatga tatagctttt 52380
gttgaagcta aaaaacttga taaaaagttt aaatctgaag gaaatccatt aaaatcttgg 52440
gatgatgaac gattattgtc gttttttgaa gaaattgcta atagatatga tgtaaacatg 52500
gggtagtata agctaccctt tttttgattt tttatatata aaatgatata attaattata 52560
aagttaaata agaaatcctt cctttttcat aaagagtata agaacgtgta aaaggagagg 52620
gatttatatg gctataaaaa aagattataa ttggctttct agtaaagcta ataaggaagc 52680
cctagaagaa aaacttcttt tctttaaaga aaaaacaggt cttgatatca aacattatta 52740
tgacaaagga aatttttgtt ctgggtttgc tcacgatcat gtagttatag aagcaaataa 52800
acaaattttt gctatctctg acgataaaac tatttatatc aatagaaaga ataattggga 52860
ggtttttaaa tatgaaggtt agtttagaat taaataacgt agaaccagga ttgcttgatt 52920
caattgtaag attagtagga gataatcaag tagaatttga tatgacagaa gaagtagaag 52980
cctccttaga agaaatcatt ttagatccat cttatttata tcaaattgat ggagaatatt 53040
attctattgt agatattgag caagaagtcc aaattgttgt tttttctgat gtatatgcga 53100
atgttcgcac gtttttctta gatactttac aattttataa catcaaaaga atggcagacc 53160
caagtttatt agataagttt ttagaaaaac aaattgaact tgatagtgga ctagaatgaa 53220
agtaattaca gacccagtaa gttcaacgcc atatatagtt ttgaaagaaa atcccaatat 53280
tcttgctctc ttggttttta ataaaaatgt ttttagcgat ttagatatta tatatttaga 53340
acctgagaaa gttaaacatt ttcataaagt agaattaaat gattttttca tagaaattat 53400
gaaatttact cgagaacgag aaggtaagat agtaaaaagt attgaatcgt atagaatttt 53460
gccaaaggag gataattaat ttgagagaat atcttgattt tattatgtat aagattaatc 53520
atttaattgg accaatttta attggaggaa tagcttttgt tgcattaatt gcttttgctt 53580
tcccacaact agcttctatt actgtatttg gatatgcttt agtattttta gtaggattga 53640
taatttcaat gttaggagtc gctttagcta atacaatata ttttcttgta gtaaaacaag 53700
aacaagaaaa agaaaagagg cgaggaaaat aatgagagat ttagatttgg aaagcctaga 53760
ggaacataag cccccacgga caattacaat tcctgatgga atcaatatta aacttgattt 53820
ctttaaaaga tatgaagagg ataaaaaacc agttatacta tcaaaaaatc cagggttgag 53880
cgaattagaa aaaatgttta cagatcctaa tacaaaaatt tatggatgga aaaaagacta 53940
gattttttct agtctttttt attttgccaa tattctttta tacctacatt aatttcttct 54000
tcgtcaggaa tatagatatc cccaaaaact tcttcaatag ttggaaaatt acttctaatg 54060
atttcatctt ttacttcaat aacagcatat accttatatt ctccaaattt accttttttc 54120
ttttgacatg ctaatttaac taagcccaat ttatctagta aatctaaaat agagtccata 54180
gcgtcataag ctgaacctga agattttttg cctaatatct cagtaattaa ataacgtttc 54240
gtaaagaaga agattttgtt cttatcttga taataccatt gcattgctcg aagaaaagaa 54300
tatattgtga taacattatc tgtttgtatt tgatatagat atttaagtgt ttctggatga 54360
atagtagtaa ataaatgttt tataggaagc ttcattttat cattttcttc caaaataaaa 54420
ccgtattctt ttaacttatt aatttgacga tttatagttc gacttgatac acataattca 54480
ttcgcagcct ctcgactaga aaagtctttt ttattaatat atctcggctc tccttttttc 54540
ccattccatt tagaaattac ttgtaaatat ccatataatc tatcaatatt tcttaaactt 54600
gtaaaatctt gtgtcgttgg aatttgattt ttatgattgt tcaaactttc tgacctcctc 54660
tctactgaaa tacaaaaaaa ttaggacagt ttgtcgtgag atacccattt gattttttat 54720
atatagcatg atataattaa ttataaagtt aaataaggga gggcaaacag taaatgatat 54780
tttttattat agtatttgct gcaatatttg tcaatatgta tcgacgcgga cgaaaagtaa 54840
ttgataaaga agaccagggc gtaacttttc tattttctgt cgctattggg agtatatttc 54900
aagctaccgc tgtttcttta gtggctatat ttttaacatt aggctattat aaaataacta 54960
atagttatga attatctatg gtagttaccc cattgacata tattaattca gagcaagact 55020
atattgttca taaaaatgga gaatcagatg aagttgattt ttatactttt gctacattag 55080
aagtggatgg gaatacaaaa ttatataaaa acatagaaat gaatgaaaat actgatgtta 55140
ttatagataa tagaacaaaa agacctaggt tagaaagagc agtgggttta attccaacaa 55200
ccctatggac atatattata agtttaaatc gtaaagaagc tactactatt agttataaat 55260
taatagtacc agaaggagct attatagaaa tgcatgaaca ggagaaatta gatgcgggta 55320
gaaaataagg caattaaaga actaattaaa gaaatggatc aatcatttga agagtttgaa 55380
aagaatatga gttatacttt atctgcaaca cctcttattc aagaaattaa agaagtaata 55440
gatcagcaaa aagaaaccca aaagagcaag aaaaggagtt ggcgtgattg gttaaagaaa 55500
ttgtggcatt aattactgtt ttgtttttag gtatcattgg tggttttatt attttgttta 55560
gtatagttgg aacgcttatg ttggtaccga ctaatgctat tggaatggtc attgttgtta 55620
ttgttggact agctatgagt aaattatatt cagttgcagt tcaaaaaatt atgccttata 55680
taagtaataa attaatcaac taagagtgat tcttagttga tttttctttt ttaaaatgat 55740
ataattaata tataaggaaa tgaaatggag agaagaaaat gaatttttta gattttattt 55800
ttaaaaaatt aaaccctaaa gaagcacaaa ttaaaaatat ttctctaaat gaagaaggca 55860
gagatttaat agttaaatta tatactgaaa tagaaaatga aaatgacatt gtttttagaa 55920
aaatatttca ttatgaagta catttattag aataaggtga caatcttatg ttattaaaga 55980
tattttgtgt gataggatta atgttttgtg ggtatattta ccttatgttt acagccgaag 56040
aatttcttaa gagaatacgg aaacgaccat atcgtagaaa gtgagctgat tctataagtg 56100
atagaatttc tattgttaat ctttattgct attatcgccc cgacgtttct cttaatatct 56160
ttacttcctc ttggaatagc atttatttta atgaatttag tgcatttctt tattttaaaa 56220
gcaataattt taggaatagg tttttattta acaataaagt taggaaattt aatggggatg 56280
attttatttg taggatgaat tggaggattt tctatgataa attgtaagtt tcataaagga 56340
gatataattg gttctacgac tgaaccaggc aagtattata ttattacaga aattaatgtt 56400
gttgacaaaa tatatattct gcgaaaaatt gaaatagatt tatttgatga gagaccaact 56460
tttactgaag gcttaatttc agtaattgat aaagattttt atagagtaat tacataaatc 56520
aataaggagg aaaaataaaa tgttaaaaaa taaaatgtta atgattagtg gttcaagagg 56580
tagtggaaaa acttttacgg ctttattata tgctagtaaa atggcttatc ctttggtggt 56640
tagagatgaa cgaatggtta aatatgtaag aaccttagca aatgcaacga atattccttt 56700
aactaaggaa ccaattacct ttaaagaata tgctaaaatt tgtaaaagag aatttggtga 56760
atctaatgat gagttagagt ttggttatgt agttgatgaa cttcaagatt tcgaacgatc 56820
tttttctgat gttaaattac ttaattgtca agcctataca tgtactttag tagagagttt 56880
tttcaaaaat gaaaaatgag ggaaataaaa atgacaattg agcagataat taaacaatta 56940
ggatccctac cagaggacga aaagaaatta aagttatatg tttgtgatat gaatggagac 57000
aatttcgcta tatgatgaag aagctaaaca tagtcctact aatcctctgg gtcttaatta 57060
ttcaatcaaa agaggtaatg aaaaatgaaa tatgtagcaa tttttatgcc agatttgctt 57120
tatatggacg ataaagtagg ggacttccat ttcatctgga atccccagac aagaatgttt 57180
caccagcgtt gtgattttga cacaacttat ccaccacttg ttattctcga aggttctgat 57240
tggttattat caaatttctt catttagaat ggattaccca aaaataaaat ttaaatcatg 57300
aaaaagaagc cacaaattat aatagatagg aagaattaaa atgtatattg tagaaattat 57360
tgatccagcg agagcagagt tagcttatag tccaaaagtt ttcagcactc aaacagaagc 57420
agaagagtat ctacaagaag cttgtggtaa tacgcatgaa ctagaaggcg ttatcgtatc 57480
agtattacta gaaaagaatt tcagtgataa tcgaatgatt ctggtgtcag cggatatttt 57540
ctatcacacg taacagaaga ggatgataaa ataatgtaca ctattatact aaccaaatcc 57600
aatggctatg gcggtatcac agaaacagaa tataacaata ttggtaatta tagaattaca 57660
gacgattttc taattatgga agattctaac atgggcggtt cgtactatat accaaaagat 57720
caaattttag aatttgagct aaaccgacag gtataaacaa tgagctatat tggaaatttc 57780
tcgagacata tttctcgcac atgaaagcac ttttgaagac atatttcgca actaagtaat 57840
atatagcgtt cccttcggga acctaaataa tagccttata ttttactcac ttcgttcgta 57900
aaatataagg tactgggcgg cttcgtacgt ggtgattttt atttgaaatt tttagtttta 57960
cgtgttataa ttaattataa agttaaataa ggggttgaaa atgttgagga aatatttcat 58020
tgattcacta ttaagcagtg tgccacgagt tcgtggtaga aaaagaatta ttttttatgt 58080
tgatgatgat agtgcattgg aagaagattt attagaagcc ttgcaagaat ctaaattcga 58140
tgttaaatgg caatctggtg cttctccaac actttttagt gctattaaaa tgaatggatc 58200
agttgcgatt ctttgtactg aaagagaatc aatggataac tttgtattaa ctttttgtga 58260
tttatattct gctttttctt gtgaagagaa agaagtctct cgtaaacttc agtatgagct 58320
ttttgctaga gcttgggggg taaagtaata tgagcatgtt acaatattat ttatcaaatt 58380
tattgaagag atgcagaaaa gatggcattt tttatgtgca atttgatgta ggtaataata 58440
gaagggtaat ggtgaaacta ttagcttcgc ttgcatcctt agaaggttat gatattgatt 58500
ggggcggctc aggaatgcct cttacaagtt actgtcctga gattgcgcaa ataattgttc 58560
tagttaaaga gaaatcggta tttacaactt gttttatcgg tctcgatgat cattctacct 58620
atgttccatt tcatttaata agtaaagtat tggaggaagg ataatggcaa ttaagatagt 58680
aggccccatt aaagaaataa cggaaaatga aaatcttata ggttggattt ctcctacgat 58740
ggatattttt agggatgaga tttttcaaaa aggcgatttt gagaaaacaa aggcttggag 58800
ggctaatata gagacatata ctcctagggc tggtggctat tcttttgcaa aaagatgggt 58860
cttggacaca gaagatatta ggtctgattg gttcaaacac gagtaaaatc ctccgttttg 58920
gtaaaaaaac aaggaaaaat aaaaaagaaa aaatccgtgt aatagacggt taagacgcac 58980
aaaacctagc ctagaggaca cattagacgg gaaaatatac gaaaaaatat tcgagagcgt 59040
cgaaaaatct taatattcga gagaaaatcc tcaatattga aatgaaaacc ctcaatcaaa 59100
aataaaaacc ctcaaaaacc ctcaatgttg tgtggcaacc cccagtcaca gtttaacgca 59160
aggctggccc cgtcctccct tacagcaaac acgacgatac gcgacaaacc tagaaaggat 59220
gatttatttg agtaaacagc ttaaaatggc agtaatccac ggaggtaaaa tggtatgcta 59280
ctttgatgat ggcactagtg aaactcatcg ctccgacgaa tggaatgtag accagatgag 59340
actccatgca attacacagg gcgccacctt cgtcagtgca ttatcggccc ccactggacg 59400
catattagaa tattatgtta atgataagcc aaaagtgcag agtatatcta tgagcgagct 59460
aacagatccc tactgggagc cccaaacaaa gagtaacggc cccactatat aaagaacgac 59520
aagcccctac tcttctctct tgggtgacaa cgtttgaaaa aatatattca taatgatata 59580
attaatatat aaatgagata tgaaaaataa ataaaaacat agggggcgga tatgtccccc 59640
tagtttactc ccccagtttc gggaggagca tttaggattt tcaattttcg tttttcaatt 59700
ttgaaagggg attttagatt atgaaattat cacgactaac tcaagaagat gttattaaaa 59760
ttatagaagg tactccaaaa gcacaagttc aaagaaaaaa atctggagaa ggctttacgt 59820
taggattaat ccttaataaa ttgactcgta atatggtagt agcagaaggt caagaaggtt 59880
tttctactta tcgagctaat gcagaaggat taatcactgg aaggaaacga tatagtgagt 59940
ctactggttt ctatattatc gctgaaaaag atgttgatgg acatcacatc aatattagtc 60000
aatctgataa tatctctaat ttaatcttgt atcctcaagc ttatactcgt gaagaagcta 60060
aagtaattgg aatgcgtctg cgtggagtag tcaatgattt attatcttat agcactgatc 60120
ttacagtaga aacaaaagta gatccatatg caattattca aaaaggatta ttaaaatatc 60180
taatgcctaa agaaagtgga gtcatttcag gcgcccatca atatatgcac aataatttaa 60240
cagacaaaaa gattggagat atagttagcc ctctctatct atctgaagaa gtacgtgcag 60300
gagctccatt ctctgttaaa aaatcattag aaaagattga ccctgacttt aaactagaga 60360
gtcagattgg cttatttgca atctggtcat ggtcacaact atttacttct atcgaggaaa 60420
atggttgggc aggttcacct gtattaaatg acctaggttt tgatcgagac tttatccaag 60480
aaacacttaa gaaatttgat gaagacgtta aaaaacatat tgtagagatg caatatgcat 60540
atacttctca gaaatatatg ggacgtgaat acctacgtga taatctggat caatataaaa 60600
cccctacaag aatcagttca tttgagtatg gaatgctagc tacctatagt ggcactacag 60660
gagcctatac tttggtatct attcaaggca aaaatgcatt cactaatcct tgtcttatgg 60720
caggtttcct tcaacctgca acctatgagg aagcaattga tgatctaact attggaaata 60780
ttatttcaac tgagccttat ggacaaaaca aaattatctt tgaaaaagca agtactagtg 60840
tatctcgtta tatcttagac aacttaaatt ctactgaaga agaagaataa aggtaaggac 60900
ccctcgtggg tctttttttt gtattagaca agataattta tcctctctgt tttattataa 60960
cattttatac agaaaaaatc aaggggtgct gagttttagg aaaaagtcct ggctttacga 61020
ggcaagcctt taacggggaa aaaatctagc gtggtggtcg acattaggct gggttccggc 61080
cgtgcacgac cggccaaaaa ataacgtccc cttatgagag aattctaatt ttcacaaatt 61140
aaaataacag ttttgggatt ttgggttttt attcatgtta ttgaatatta attcagggag 61200
ctgaaaagcc catcatatca acgttttggg gcggtgttat tttataaatt aagttttttc 61260
tgttatttta tgttttttta ataacaagag aattttaatt tttcacaaac tattattaaa 61320
aaataacaaa aaaattatta gaaatctcta attttacaat tttgagaaaa atttgatttt 61380
cagaaaattt catgaaaact ttcaaaaata ttttcatttt catagattaa aaaatagtga 61440
gatttctctc accattttct catttattga ttttgaaaac ttgcttcaaa atctttcatg 61500
ttaatttcag caattttttc agaatgaact tttgtaggga tacgccagca cattctattt 61560
atttttcgat tcattttttt atgttgttta taacaccatg ccataatttc cgtttctata 61620
tatacatcag caagccctgt atgttcttcc acaaaatcgg ttgttttcat catccaatta 61680
taagcgactt ctgcattagt tttcagattt ccagcttttg agtaataacc attttcaaac 61740
gcccactctg gaaagctctt ttgtgaaaaa attgtctggc aagccatatg ccaaatgcaa 61800
ttgatttcta aattttttcc aacttcataa ggaaagaaaa acggatagtt tgtcaattct 61860
tgccatgtgt tatttaaagc tttaacaaaa tcaaaatacg cgttgtatgc tgctacggtt 61920
ttgatattgt atttttctat aatgttaaga ataacttttc tcacatatct gaacggcttc 61980
acttccataa ttcctttaga aattttttca cgatacaaag gtaattttgt atagtaataa 62040
gcgctacgca tcaaagcatc atcgtcaaaa atttctgaaa ttgcgaacga atgttcttcg 62100
taaatattcc cttttttatc agataccaca aagccaacat cataacataa tggatttttt 62160
tcaacgtcgc cagctgtttc tacgtctaaa actaaaatgt atttttttct tttgtcaatt 62220
ttcatgctta ctgtatccac ctttttaata aaatattttt ttgaaaaaat aaaaggctag 62280
gcttttacgc ctagccttag acgttcctta gataatttta tagcccactt ttttcttgtc 62340
gcttgttgcg attccttttt ctaggactcc ctcctcaact agacctttta ggcgtggggt 62400
cattttttga ggtgtatagt caaactctaa agcttcattg acttcttggc ttgtgtaaaa 62460
tgtttctgga tcagcttcct caaaaaacca ttcttgaatt ttttgcatgt ctgcaagttt 62520
ttctttgttt gtcttgcttt gactaggttt gcggttggcg ttacgttttc gagcttgttc 62580
gcctttttct actacaaaat cgataacttc ttgcggtgct ttcacgtttg acaagatacg 62640
agcaacctct gcaaattttt cagctacgac cattttttcg aattgtgttt tttccatgat 62700
aaattccacc tttttaaaat tttgttagta agttgttccc ttactactct ttaagtataa 62760
acgattttca attattttgc aagtcttttt ttgctttatt agaaaattct catttaagct 62820
taaagagtaa caagtgaacc tccctctcaa gtataccata ctttttttaa ctttgcaagc 62880
ataaagttta tttatttttc aaaaaacttt ttacgtcttt ccttatttct ataatactat 62940
tataacaaac ttgaaaagaa attgcaagca taaagtttat ttatttttca aagaactttt 63000
tgcaatctct ttccttatct ctaatactat tatagcaaac ttgaaaagag attgcaagca 63060
taaagttcta aataatttta tcaattgtga tttttttgat tagtgtttca agtgtttgtt 63120
tggttggttc gactagtaaa cgatagtcag catgtttgaa taaaccgaaa tcgctcgcag 63180
tatctcccca cgcctctata taactatact cgtttgtgtt tatgttccat tgaatgcagt 63240
cgtctttttg tgattctgaa aacattccct taacttttcc agtaaaccga tcatttgttt 63300
tcaaatattc cgttgcataa tatgaacagc ctaaaaagtc agctaaatgt ttaactaaaa 63360
aatcgctcga acctgtaaca agaataacct caaagccttg taaaattttt tcttttaaat 63420
cggtcaaagt ttgataccaa tttttttcat tttctaaaaa ttgagaaaca aactcttttg 63480
catacatttc tttttctgtt tttcctgtta tctcattgcg ataattttcg gcaaccgcaa 63540
cgatcaaact ttcatttttg acatcttttt tccatgcttt ataagaaccg tcgtccttga 63600
taattccttt ttcaattaaa aaacccgcat gagataaaac aacgcttttc cttgtaagtg 63660
ttccgtctac atctgttaaa attaaatttt tcatttcttt cgtcctccct ttatcttata 63720
tacttattat aagggagaaa cgacaaaaag taaagcattt tatacaccaa aaatcattaa 63780
agtttaatga gaattgtttc taatttacac acaattcacc aggcgttatt ttataattaa 63840
ataacagctt ttcttcggac acatgttatt ttataaacct ctaagcgctt acaaactgcg 63900
tcagatcaag ctttcaaaag attttcagaa attttcattg ttgtttcaat aacaagcaaa 63960
aattacacgt gaaataattc acaaacataa aataacaccc aagagcagaa aaataacaca 64020
ctctggcttg tgcgcacatt cacattctct tgctctcttg gaatgaaaag gctatgaaag 64080
cttgatataa taggctttct ggattgtgaa aaaattcaca tgcatggact tttgggatat 64140
taaaataaca ttaaaaaaca attaaataac aagccaaaaa cttgacaggg ataaaataac 64200
acagtaaaat ggcgctcgcc agcgagcggc cgaaaaataa cgtcctctat ttgttatttt 64260
attcatttca caaactttag tttcaggatt ctgttatttt atttttgaaa atcctttttc 64320
aatttatgaa aatggaaatg aaagcttgat agatcaaggt tttgggaacc tcgccccaca 64380
atgttatttt atcttattcc ttttgggctg ttattttatt ttatacattt cacaaacttc 64440
acttttaaaa taacacgtat ttctttgtga aaaaattcac aagcaaaatt aaaaaaagat 64500
gagaaaaatc tcatcttttg tttttatgat aatcactaat tttttttagc tctgcggtgt 64560
taataatata ctcattacat aaatccaaaa ggaaatcctc aaagctttct ttttcgcttc 64620
ctcttgtttc ccaaagtctt tctaattttt gatacatctt tttattactt aaaataatca 64680
tttaaattca ttcctttcct ttactatata tatagtataa catgtaagta aaagggagtc 64740
aacccttttc ttcaatttct tttatgattc ttttttcgtc ctctggtaac atttggataa 64800
cagtttttac tactatagtt ttatctgttt cattacaaac atataagcga gaaccgaaaa 64860
cccacaattt aaattcattc tgttcatttt ttggcgtttt ctttcttacg ttcttaattt 64920
gaaaatcgtt aagaattgcc gaacggactt gcctattatt cattggcttt ttggctactc 64980
tttctaagta gcgttctttg gcgtgttgtg tgataataac ttttttagta aacaaaagca 65040
tttgatccaa ctcctttcta tattcttatt atatattata agggctgaaa agtcaaccct 65100
tatatttttt taattttttc gtttgttata attttttcca tatttttttc tacttcaaat 65160
acatggaaaa aattccaaag cctatgattt tctgtgttat cataatactt cacaccgtca 65220
aaaaagcagc acaattcagt cagttctgta gctttttcat catttaaaaa atcaattatt 65280
ttataaatat attcattgtc aactttaaat ttgttttttg aaacaattgc attcctaaaa 65340
taaaccttga ctgttaattt tttagtaatt aagtttagtt tcgtttttat gatacaagct 65400
tcatctgttg acttttttaa atataatttc ttttcttgaa atgttttaaa aaatctcatt 65460
ttattcactc cttattcttt atattattat tataacaggt ggtaaagggt ttgtcaaccc 65520
tttaccttat attttttagg acttccgccc aaatcttcta aatatccctt ttctttcatt 65580
tttttcaatc tgctaggtgt ctggcggttt gtgtatttat cagcaactaa caaatgaaag 65640
tccttatttt ggaaatactc tttcccacca aaagcaattt ttactacatt gtgaaatagg 65700
tcatcaattt catcatctgt aatttttgat tttgcatttt tggctttctt gatttctttt 65760
tgttcttttt cgaagtctgt ttttttgtca ctttcaaact tatcgaactc tctcagctca 65820
atagcttcgg caagattcaa ctctaatttt tcaaccattt catcaattaa tttccaatca 65880
tgagaagtaa tcttttcgcc attagaaaat gtttcttgca tataacacca ttcctttcct 65940
ttactatata catagtataa catgaaaatt ttttcgtgtc aactattatt ttttatttta 66000
tttatttttt tgttccctcc ttaactttct ataacaatta taacagataa aactaaaaaa 66060
atcaaataat aaatacatga gttttaggat attttttctc attaaacttt tagaaaaatt 66120
tttgattttt ttcttgacat agacctaatt ttgtggtaaa atttccgccc gaaaacggca 66180
aatttgctca ctatttcaca agccttcaac acaaaaaaag atagcttttt taagctatcc 66240
taaaatataa tcataccaaa gaaaaagagt tatgtcaact ctttttctta tttaaatttt 66300
cttcattcac aattcgccac gcttgagggt taatagaata ggcatgaata ggaatttctt 66360
tttcttgatt taatagaaaa tgcagaattt ttgtttcatc tatgctatct tgcaaagcgg 66420
tatgttcttc aatgtaattc gtatcattga acaaaaattt ataagttgct tctgcaccgg 66480
tttggtaatt tcctttttct gttaaaaggt tgtgagtttt tgcaaactct ttatactctg 66540
gcgtattcaa tacagtataa gcggctactg gataaatatc aatcaaaaag aaattatcaa 66600
agaaatcaaa atcttttccc gaaaaaaaga aatgggttct tgcaattaca cgagtatcaa 66660
aacctaaatt gtaagcgcca atgtaagcaa cattatattt tttacaatct tttttaagtt 66720
gtccgataat gttcgcccac ttgctaacaa tgattctttt ttcaagtaat tttgtaaaat 66780
agattttccc atcaactaca ttttcatcaa ttaagaaagc acgtttttta tttaatgcct 66840
gaaatttgaa ttgttccacc atgtaagaac gttctactaa aatatttccc cctttgtctg 66900
aaataaccca accaatatca aaaactgact gataaggcat tccctcgccc tcttttgtcg 66960
tttcagtatc taaaatcaaa aatgtttctt gcatgtaatt ttccaccttt tcaataaatt 67020
tatttgttcc ttaactacta tttaagtata acaaaagggc ttgagcttgt caagcccttt 67080
tactaactta tttcaatttg taagctactt ttttatcctt tacaactttt tcaaattctt 67140
cgttgtcgac taatggcttc atgattgccg tcaatttttg aggtgtagca ccaacaagcc 67200
caattaattc agaaatttcg ttcagtgtca aggctgtttc tggttctagg tcaagaaatg 67260
cttttcgtac tttgtccata ttttcagctt tttcttttgc tgttttgctt acgccttttt 67320
tgccacgttt tgccttgtct tgtttcactt gttgagcgtg catagcttcc aatttgttta 67380
gtaattcaat atcaactttt tcaaataagt cagtatttaa aaaagttttg tcctcgattg 67440
ctttgcttac tactttactt gctaattcca atgcttgtgc ttttgtgatt tgtttttcca 67500
tgataaattc caccttttta aaatattttt ttgtaataat ttcttattac attcttagta 67560
taaaacattt tgatttgttt gtcaagtgtt ttatactaat ttctaacaag aaatttttaa 67620
attaaatcat tttcaaaatc agaaattaaa ttatctaatt cagtttcttt atactctttt 67680
ttatttttta aagattccaa aataagaact tgccacaagg ttaaatctgt ttgtgtgagt 67740
tgactacaat accaacaagc ttcttttaaa gagaaagttt tttctttcat ttatttcaac 67800
tcctttctat actcttatta tagagtattg agaaaggctt gtcaagcctt ttcccaattt 67860
tcttttaaaa aagtaacaac gctataactt gtaatagttg ttagagcaat aagtagcaaa 67920
ctttgaatag agaaaaatcc agtatataaa atagcttgat aagtaaagta gaatggtagt 67980
aagatacctc cagcgaccaa aattcctaca aaaacaatta ataatactaa ttcagataat 68040
ttcattttaa aacttccttt ccttttctat atattaagta tatcattact aaaatgtttt 68100
gtcaatactt ttttgttaaa taatttcaaa ttttctattt ttgtattctt ctttgaaatc 68160
ttgaacagct tgttcataag tatcagcttc aacagaaatt tcttcgattt taggataacc 68220
actatccaaa ctaatttcat ctaagaattt aacaagtaaa atatatttat tcattttttt 68280
catccctttc cttatcttga ttctattata acacgactta attcatctgt caacactttt 68340
atcattttat cagctttttc ttttcggtca atttcttttt ctctttggtt ctttctagca 68400
atcaatttca atcttaaata tttatttttc atttcaatcg ttcctttcta taattatata 68460
ttagcaaacc ttagaacttt tgtcaagcat tttattaaat ttattttttt tattttattt 68520
tttttgttcc ctccttaact ttctataatt attatagcat agaccaagag gaaagacaat 68580
aataaaatac tgtattttta attagaattt tctcattttg tataacagat gaaagcgctt 68640
tcattttatg gttccctccc tgtttgcggg gtgttctcac ctctccttat tctttatata 68700
tttattatag catgagtttt gggacaagtc aacagaaaaa cgccaaaata aataaaaata 68760
ttttttcaat gaaagcgctt acatttcttt cctctcttgg tacaatatta ttatagcaca 68820
aaaaaaggac ttttgcaagt cctttatact aattcttttc cgattatatt tctgtctaat 68880
acgtcaattt tttcttttac ttcttcatta tctaaaaatt tatttaagtt ttcttcattg 68940
aaatttttag ataattcaag agctaaaatt tcactatctc tcaatggata gttataattg 69000
tttattcttc caccaactac tggaaaacat acctgttcgt tagtatcaaa atctactaaa 69060
tatatatcta aaattgaaac attattccat gcaaatgagc cactagcgcc agcattcctt 69120
acaatttttt cggaagcttc ttgatttgat cgaaacatta ctactttagt aactcgatta 69180
tttattgttg tcactgtttc ttttctatcc attaattttg gatcatgatt gtatattctt 69240
cttctgtacc acgcttcact aatactgtaa ccaattataa acaacatcat acctaatata 69300
acaattaaca taagactacc aaaaattatt ctcatttaaa aatcattcct ttcttttaac 69360
tataattagt ataccatagt ttcggggtgg tgtcaacaac tattttcatt taaccattta 69420
acaaaatcat tatagacttg atgaatgtca aatctatttt gaaattgcat actaaaatca 69480
tatttgttcc gtaaccattc actaagtaca tagctatcaa ctaaagggct attaagcttt 69540
ttcttatatt tagataggta ctttcgttct aggtcatact ctaaagcaat ttctaaaatc 69600
tcaatagctt caagagattc attattcatt tttaaacacc tctttccagt aagttttagg 69660
gctattcatc taacccctat aaatagtata atatataaaa ccctaattgt caaatgattt 69720
ttaacattag acaaaatatt tttatataca ttatgtatgt atatatgcat ttgataacag 69780
atgttatttt aatagactat cgatagatgt aagcgcttac aaaagattta cttaaagaga 69840
tgaattgaaa gcgctttatt ttgcgtttta agggcttttc atattatttg gcataattat 69900
ctattaagca ttataaaacc caagagaaga gcaaagaagt gtattgtggg cgctattatt 69960
gtcttttatt aaggtgctga aataaatagt cttatataaa ataacattta tcagttatta 70020
taacaagtgt tatgtttggt gcagagatgt gatgaactaa tacattgtga aacatttcac 70080
acatgtacaa tcattcatat aataatttat tcatatgtat agatgaacag atgaacattt 70140
attcatatgt actcactgct agtctgtgag cattgtcaca gatgtaagcg cttacaactc 70200
actgacgcaa ggtgtcaagc aaagatactt ggcgcacata tgttcggttc gttcccagca 70260
acttgatgaa taacaaaggt tatttaattt tatggttcgg cgtttaaaat aacaagtgtt 70320
atttaaacat acttaaatac ttgaatagat atacatatga acatatattc atatattgtg 70380
gcagtaggta cagatggact agaccaatca caaccataaa cgattgtgaa atatttcaca 70440
aggattccac tcaacgttag aaattagttg atattattaa ataacaggtg ttatttttgg 70500
tggcagcaac gcagatgaat gttatttaat aaacaaggga gtaggtggca aggggtatac 70560
aggtcgttat ttaactaggt caataagttt ttacaatagt ggtaaaaggc ttgttgtcat 70620
tagggtttgg gcgttttcag gaatggaatt gagattggaa ttggatttac aattgttatt 70680
tccgcccatg ggggttgggt tcatgcgggt cttacaggct gttatttttt ctgaaatagc 70740
ttttggtggg gatggttttg ggatttgtga aaatattcac aagtcaatca gggaagccgc 70800
ggcaacaaca cttaatcaga gcttcaaaat tgaaaatcgc atgactgtct tttttctacg 70860
gcgtctcacg gttggggtag atttatctat agttctgccc agtttttata ttgataccag 70920
agtaaatgta aataaaggag gagttcgaca tggcaaaaca cgtcatagaa gaagagcttc 70980
tgcatggttc gggctttaac gtcgtaacta atggagaagt agaaattaca gctgataacg 71040
ccgagcggat tttaaaattt attaccgatg gcacaattga tattgacgtt attaatcata 71100
atattaaatt tagctctcga gttccagtat tcacaacatt agattggtaa aggaggatgt 71160
gaataaatga ttaagtttca caaggttagc ggcaaacccg ctaaagtaga atctggcgat 71220
gaaaatattt ggttttctta tccaaatggt atttatgttg ctgataatca aggtaaccca 71280
cgattaattt ccccagggaa aatgattggc gatgctgttc ctgtgggagt accaaatgag 71340
ccaggtctat tttattataa tacatcaaat aaaaagaatt atatttccac cgccgaaaaa 71400
tgggttgaaa ttggcaccgg cagtattcca gggacaggtg gaggcagcaa catcgctggt 71460
aatgttttaa tcaatgatac cgccgataat tatacctcgg tagatgttga aggcgctctt 71520
gctgaaatcg ccgaaaaatt cccatggtat tttggcagaa tgcaattaaa agattttaat 71580
ggtgacgtta atactctatt aaaatccact gaaaattata ttacaactac tgccgcaaat 71640
cgccccaatg gcaaaacagg ttggctcatc caacgcaagg cttctaataa caatacttat 71700
ggattcgtca ttggcgatga tggcaccgcc caaacaaggg tcaacgatag gttcacccca 71760
ctagcggccc aatcggacct tgccaaacta caaaatactg ttgattcctc tcttggggaa 71820
ttaaaggtaa atgtaggaaa gggattagct tctgatggaa agacattggc aaatggacaa 71880
actatttcat tagcacaaga tattttagat aaaattgatg ccgccggagc tggagctaat 71940
tttgttaaaa aagctggaga tactatgact ggttctctag taatgaaagc tggttctggg 72000
caggtttctc aagtacaatt tagtagtaca ggttctgcta ataatgtggc aatattggat 72060
gacccaagag gaacgtccaa gaattctcct tatggaggaa aagaaggcgg ttctcgtttt 72120
agaattgcta atgtgaggaa gaatgtcgat atcatgtcag cttatagcga tgggtcggtt 72180
gatattcatg cacatggtcc tcgtgcggta tttggtaatg taagtactaa tggacgaact 72240
actattttga ataataataa taatggtggg acttcagttg atatcgttgc gccttttagt 72300
aacgttccat tatttgttaa gggtaaaaat ggacagctac attataaggt taatggtgga 72360
atgaatagtt tgctttctgg taacagtagc ggtggtcgta aaaatttacg tattgctggt 72420
atgggaagta attctgaatt ggctacattg tattttgaag catggaatac aagagctaaa 72480
ggtaaaattc attctgggtc agctattaat gttggtttta accatgaaac ttctaagggt 72540
actggtgatg gggatgtatg tttacgtatc ttcccaagaa aagctgggct taatggtgag 72600
agaaatgctt tgagaaacta tgctgtatta tattatgagc aatatagtca aactttagtt 72660
gttgactcat tcaagggtaa tgcaaacttt acaagcaatg aacgtaataa ttttgtacgt 72720
ttatcttctg atggttttat tacacgttct tctgtaaaat ataagaatcc tattaagaaa 72780
tttgaagaag atgctttatc aaaagttaaa gaagttacac ctgaattgta tgcttataaa 72840
aatgatccaa aacaaagtac tcaattagga tttattattg agcatggtct tccccaagag 72900
gtagtagaaa tggaagggcg aggcgtgaac gcttatgcgc tgacagctta tttatggaga 72960
gcgacacaac aactgtctca agaagtagat tcattaaaag aagaattgga aaatttaaga 73020
aatagttaag attaaaaaga gaacttgaaa aagttctctt tttttacttg acattattta 73080
gtctatatga tataatataa atatagaaag acataaaata ttggaggaat aactatagat 73140
ggcatcatta caattaaata atgctttaca aacctatgaa gaaagattag aatgggttaa 73200
taaagagatg aaaagaattg gagaagataa attaactcca tatcaacgag ataaaattgc 73260
tacatattta atagatggaa ctaatccaga atctcgtgga gaaattatta cagctaatcg 73320
tttagttaca gtaaataaaa gagaaacttc aagagaagga ttaatggaaa agcttgaagg 73380
aggagaaagt gctttccatc aattaattaa acaagataaa aatgtaattt taacaccaaa 73440
ggtagaaata acagaaaaag atattgaaga agtacctggt ttggcacaac taagagaaga 73500
aattgataaa ttacaaaaat atttagatga aaatccagat atgcctaaaa aattaacagg 73560
gaaaattaaa caaacaatta ttgaaatgcg tagagaccaa tatgttctta aaaattctca 73620
tcgtcaacca atttttggaa gaggtaatac aggaaatatt gaacaagata ttcattacga 73680
tactattaac ctacaacaac gagatcaagt attatcatta ttaatcaact atagtagctt 73740
aaaaattgaa tttaaagata ataatgattc agatattaaa tgggttttag aagatcttga 73800
tagattaatt caaaaatctc ttgctgaaaa acctacttta ctttatattt taaatgaaaa 73860
aattattggg tcacgcaatg atgaaataag agaaggactt attgaaattt ttggagtaga 73920
tcatacacaa gaatatattt catctttata tagaaataaa atcccacaaa ttattgcaga 73980
cgctgcaaca gaagagtgga ttgattatat gtacatgaac aaacttaagg gaacttacaa 74040
acgttgttct cgttgtaaag aaattaaatt agcaaataat cgtaatttta gtattaatag 74100
aacatcttca tcacagtttt attcaatttg taaagaatgt cgtaacagca aaaaataacg 74160
aggagttact aatatgacag ataagaaacg agtaattttg gatacaaata ttttgatgag 74220
tacaaaaaga attaacagtt taattgagga atttaaagat tgtgatttat tagttacact 74280
tggaactcta ggagagctag atagattaaa aactgctgaa ggtcagcgag gatttgaagc 74340
tagaaatggc ttaagaatgc tccgagaaaa tgaagaccta ttcacaatta tcgacacaga 74400
aaatccagaa agaccctctt atgataaatc tactgtagat ggggatatca tattcttggc 74460
gcaaaaagag aatcgtttgc tttccgagat cgaagtaata actaacgacc tatccatggg 74520
aacagtagct aaagcaaata gggttaatgt acgaaccttc tatgaagacg cagacaaata 74580
tcgagaagga tatgcagttg ttgatgtctc cgacgaatta gaagatgata caaacgcaat 74640
gctatttgcc ctagctaacc aatatatttc ctctcttggg ctattagaaa atgaatactt 74700
agtattagaa aaacatggag aaccttactt ctttgttgta gaagaaggtc gtgccacaaa 74760
aatctttgat aataatccag taagatacaa taaacatatt aaaatatgct cttctgaatt 74820
tggcacttta aatcctaaag aaaaagatta tgctcagttt tgtgcttttg atatgttagg 74880
caagcatgat atttcgctat taactggtcc tgcggggtca ggaaaaactt atttaatgct 74940
tgcaaaacaa tttgaaatgc tagaaaaaga agagatttgc aaaattacta tatttgtcaa 75000
tccagaaaag gctcgtggag ctaaaacact tggtttttat aagggtgata gaaatttaaa 75060
attgatgcaa gaatctattg gaggaatttt agcatcaaaa attggtgaac gagaaaaagc 75120
aattgaatat attgaatctg gacttattga aattattcct atttcagata ttcgaggtta 75180
tgaagttaca gaaaattctt ctttatatat tacagaagct caaaatttaa ataaagattt 75240
aatgcaatta gccttacaac gtgctggaga aggaaccaaa gtttttattg agggagatcc 75300
aacaactcaa ttggattcgt gggcttatga aggtgataat aatggaatgc ttaaattaat 75360
tgaagttttt gccggaaccg aagtttttgg caatattcat ttaagtaata tttatcgctc 75420
gcgtgttgca gacctagcag aacgaatgac aaaataatat aagacattat gtccagcttt 75480
caattattct gaagctggac atttttatta aattaaggag gtttaaaaat ggctcaggaa 75540
gaaaaacaaa agtcagtagt agaaatgcaa gcagaaaaaa ttcactgcga acattgtaat 75600
agattttatc ctgcaaagga tttttataaa gataaaaatg gagacccaat gaaaaaatgt 75660
aagaaatgta tggcatctct tattgattta aaatctccat caacagtaat gaagattatg 75720
gaagaaattg atattccata tattccagat gaatggaatt cattaagaga acgatacgaa 75780
ttctcaacat ctaaagatgg taaaactatt cgtaacaaaa atgcaaacca atctgtctta 75840
ggacgttata ttggtaaaat gcgattagaa caatataagg gttataaatt ctctgacact 75900
cctcaattta tggaacaaca cgatcaagaa attcagcaaa aacgtgatat acttcatcaa 75960
aaactagaag atttattaga caaaggttat gatcctgata ctgctatgca actaatggca 76020
gggagaattg atacagaaga tgaagatccc gcattaacta aaactcaaat aaaagaatta 76080
aaaattaaat ggggaacttt atataacgaa gaagaattaa ttcaattaga aactttttat 76140
ggggaaatgc acgaatctta tgatatcact tctgcttccc atgaagatta tttaaaacaa 76200
atctgtaaag tttctctacg tatgcacagt ttaattgatt caggaatgta tgatgaatac 76260
caaaaattat ctaataccta tgataaaatg atgaaatctg ctaaattcac tgcttcccaa 76320
gagaaggaag aagataaatt cattgatagt atctctgaaa tggtgcgttt atgtgaagaa 76380
gaaggattta ttcctgtata ccatacagat gagccacaag atatcgtgga cgttacattg 76440
cgagatttca caaactacgt acgtaattta gttgaaaaag aattaaactt agattctcta 76500
attgaaaaag gcttagaaca aattaaattg gacgaagaaa aagaacaaat gtctgcagat 76560
gatgctctat ttgtggaaga agacatgatt tctgatgatg atttattgtt tgaagctgtt 76620
aatactgagg ttctaccaga acttacggat gaggctaagt tattgggggt agagcttgat 76680
ggcgaagaat aaaaaacatg aagataaaag tacaactatt attgatatta aatcagattt 76740
tatcaactct aaaaaaaatc gagaagtatt tttaacagaa gagagagtgc gcgcaagcat 76800
tcctactttt acagaatatg tctccttttg gagagaatat ccagatatgt ttattgatat 76860
gataaagggt ccagatagca aatttaattt tttcttttat caaagattat ttttacgtgc 76920
tgctatgagg cataaatact ttttcggtac ttttacacgt gccttttcta aatcattttt 76980
atctgttatg ctgatgatgg aaaaatgtat tttatatcca ggaattaaag tatttattac 77040
ttctggtggt aaagaacagg ctgctggtat tgctgcagaa aaaattaatg aaatttgtga 77100
tatgatacca tcaattaaaa aagaaatcaa ttgggcgcca gggcaaacga agcttaatgg 77160
taaagattat gtacaggttg tatttaaaaa tggaagtcga ttcgacgtag tagcagctaa 77220
agaaagttct cgtggtggac gtcgacattc aggacttatt gacgaggtta ttttggttga 77280
cggagaaaaa ttctcacaag ttatattgcc taaacatatc tgggcctctt agtagtaata 77340
ctaaagagat aaggtggtga acctcgatta caagagggtg tccgaaaggg ctaacgaggg 77400
aaaccttaga atcttgatac aattctaaga taatctcgtg ccaagccttt gtgaagatca 77460
taaaggaagg tgtagagact atccgaaagg agtaagatgg agatgttacc atctgaagcg 77520
ccacccatcc taatttaaat aacaagagag gatgaagaaa tagtccaatt attatcaata 77580
attgatgatg aacgtatcac gccgtgcggc gaatgggaag gttgacccaa atgataaaat 77640
gaataaatct caagtttata ttaccagtgc gggttgacat acaagctctc actataaaca 77700
ctcactctaa ttgctgggaa atcctttata aaaggacaat cagcagcgaa gcctattaaa 77760
aatataatag gaacgttcaa cgactattcc gaaaggaagt acattcaagt gaatggaaac 77820
gggtgactcc tgaaaaggga gaagatatag tctcttctat atggtaacat atagcagttc 77880
ataagagaac gctgcaaaat taacgacttt gcgggaagat aaagtttaaa gatcatttta 77940
gttaccaaaa acaaattcag ctattagtat ggcaattaat taaacctggt accgctatta 78000
ttatgggggg aacttggaga actcctgtta aaatgggatt attagatcca ggttttgtca 78060
acgatctaaa gtctgatggt acttttgacg aggtatcatt taaccgtgag tgaatctctc 78120
atgctcacgt aaaatgcaat taattgctgg gatatcctaa agctttttaa actacaacat 78180
aagaagaaat tctaagtgtg aatgttaaaa attaaaaaga taaatggaca atcagcagcg 78240
aagccccttt cacatgggga acgttcaacg actatccgta aggagtaggg aaaccgaaat 78300
attgcataaa tatattaaat atgatataat catagtaaga ggtgaattac tatgaatgga 78360
aaaataatag atattgctcc aaattatatt atatatccag atggaaatat taaaaataaa 78420
aatacaaata aaatgttagt tggacaaata gggaaaaatg gctatcgttc agtgaatata 78480
agaactctta atggaaaaaa acgggtttat attcataggt tagtagctat taactttatt 78540
cctaatccgc atcacaaaga acaggttaat catattgatg gaaataaact taacaataaa 78600
gttgagaatt tagagtgggt ttctccgaaa gaaaatattg ctcatgcaaa aaaggaatta 78660
ggttttactc ctccaccttt ttctgaagtt acgagagaaa aaactaaaaa attaaattct 78720
aataaaatag ctaaatatga ttgtaaccaa aatttaattt gtatttatcc ttctataatt 78780
gaagcatcaa gacaagaaca tgtttctcgt catagcatta aagatgtttt aaaaggaaaa 78840
aaaggaaatc acaaaggttt catttggaga tatatttaaa gatatagtct agttccaacc 78900
gaaagtttgg atgtatatta gatgagagtg tttgggctgg ttctgcgaca gaatcattct 78960
ataatggaga cgttttcgat agatgtagag ttttaaaaca ggctgaattt acaagaagtg 79020
gtcgaggaaa tgatgaagct tattatgtac tcggagtcga tgtaggtcgt aatggttggc 79080
aaactgttat tacagtggtt aaggtaaatc ctcagcgtaa tggtgtagga attaaatctg 79140
tagttaatat gattgttatt gaatcggagc atttcggaat ccaagctaac gaaatcaaac 79200
gtcaatattt aaattatatg cctcgttatg ttgtagtcga tggtaatggt ttagggattg 79260
ggttggtcga ttatttagtt atgccttctt cagatagtaa aacaggagaa agtttttctg 79320
cttttgaggt tgttaacgat gataaaggtc tttataaaaa aattgataat catggcgata 79380
gctatggtaa agttttatgg attgttaaag ccgactcaga attaaacttt gagggttata 79440
ctgcactact tcaacaaatg ggttctggta aaattcgata tttacaaaac gagcgtgatg 79500
caaaaggtga tttagaaagt aaaaaagcat ataaaacaat gtcagcagga caaaaagctg 79560
acgctattag accttttgta ttaacgtcta cactaaagaa tgaaatgatg aatttaacta 79620
gacctgaaaa taatagcact aaatttagct tagatagaat taacaaggga atgggtaaag 79680
ataaggtttc atccttaatg tatgcaattt atgtaattaa gttacaagag gacaaagaac 79740
ggaataagaa gaaaagtagt cttgctaact ttgcattctt taactaacga aaagaggtgg 79800
aacaatgagt acattttctg gagtaagtag aggacatcta agaattcgtc atatcttaga 79860
agaaaatggt tttaattggg aagaagaata cagctttcct gatttagtcg cttctagcgg 79920
ccgccaatta gcttttgact ttatggtaat ggacgacgat ggaaatatag attttgctat 79980
agaagtcaat ggtgagcaac attatgaacc agttgctgct tttggaggaa aaaataaatt 80040
taaacgtcaa caatacaacg accatcaaaa acggttatat tgtcataatc atggtatccc 80100
attagtagaa attccatatt gggaacttga aattgttgat attggatatc ttttggaaaa 80160
agcaggtata taaaaactag aggccgatat tgcataatat cggtctttaa tatatagttt 80220
tataaggaaa gatttcattt tccaagagat aaaatagaga aaaggaggaa tataattcat 80280
gttggacaaa tcaaaaagac agagaagaaa gccaactcca gtcaaaaaag aagaaagaaa 80340
actttacgaa aataaaaaac cttcagtaga tttttcttat tatgctgaca gaagcttcac 80400
taattttggc ttcgggtctt atacttcaga attaggagaa tcatttgtaa caactgacga 80460
cattcgtaaa gctttggata aagcttttag acgaaaagat gttaaaggca ttaaaacttt 80520
gtcaagacat ttttatagag tttctggtgt gtattctcgt gcggctgaat atttagctta 80580
ccttccaact tatgattata tgattactcc tcgtgtagta ggcacaaaaa ttaatgaaga 80640
tactattgta cgagaagttg ttaatcaact attgttctta gaaaaagcaa aattaaagca 80700
atctcttcaa tcaatttcct tagatgttat tgtagatgga gtagcttatg tatattttag 80760
acgtagagga aagcaagcag tttttcaaaa attgccaaca tcctattgca gaactagaag 80820
tgttctaaat ggattcccta cagtagaatt taatttagat tattttgaac aatttggaac 80880
agaagaagaa aaagctatta aattaaataa cttcccacca gaaattgtac gtgaatataa 80940
tatttggaaa aatgataatc atcgaggaag aaacagttct aagagacgtc aaaatcaaag 81000
tttaaccaat tctggtacat ggatcttatt aaacccagat acttgtacag ctttttattt 81060
tagcccttca ttacaacctg tactagctaa tagttttttt gctattttag atgtaatgga 81120
actaaaagga attgaaaaga aaaaagctga aaatgaacta tataacttag tagttcaaaa 81180
atttggtttc ttggatgatg gagaacctat cttagaatta cctgaaatgc aagctttcca 81240
cgaaagtgcc aaaaaaatct ttgaaaacag taaccaaaca gacttactta ctactcttgg 81300
agaaatccaa aatgttaact taaatgaggc tgctgctgat ccgattgatt ttgagccttg 81360
gactaaatct atctatgcag aacttggtgt ttcaccacaa ttattctcta cagagggtaa 81420
tatggcttta gaaaaatctg tgaatattga tgaagctatg atgtttactc ttgttgaaaa 81480
atatcaaaat tggttaaatt tcctattaga taatgagttc ttagaagatg atgatgatat 81540
gtttgataca tcactttggt tcccaccaat tacaattaat aatcgtaatg aattatctac 81600
aaaatataaa gatatggcaa ctttaggata ttcaaaatta ttaccagctc tttcactagg 81660
tcaatcacaa ctagatatta tggcttcacc tatctttgaa aattctattt taaacttagg 81720
aagtattatg aaaccattac aatcatcaca cacagcatca ggaaaatcta attcttcagg 81780
ttcaagcagc ggtggtagac caccattgcc agattcacaa aaatctgaga aaacaattca 81840
aaatgctgga ggataaggag gaaataaaaa ttgaaagatg aaagactatt attttttaca 81900
gatattcaat tcttagaacc tgtcgcaatt gaagaaaatc caatgctttc taaggttaaa 81960
attaagattg cacagtcagg gattaataga aatggatatg atattcctaa agcagtatta 82020
gaagatgctg caaaaacaag cttaggtctg acaccaattg ttgcttatta caatcaatac 82080
aaaggagatt ttggtgagca tggaacccaa gcagtatata atcaattagg agaatatgta 82140
actacagccg atacacaagc agtaggtgta attccagaaa atcctattat ttattgggac 82200
gaagacaatt atttagtaac ctatggctat ctatggacaa gtcgatatgc agaattaatt 82260
gatgcattag atgggcgtcc tcaatcaatg gaattgagtt ttgaaaatac aattatgcac 82320
caaaagggca gaattatgga aattactaag actgcttttg ttggtttatg tatacttgga 82380
aatgatgtta cgcctgcttt cgctgatgcc tctattgaag gagttaattt ctcttatcaa 82440
ccattgacag aacaggaaga taaggtagaa gaaggagtag atgaacttat ggatgcatta 82500
aaatttgccc tagataacaa ctttgatgat tctgctcttg gtactcctct tgtagttgat 82560
acagatggag aagagagaga caaggttaat cgtgaaaaga ttactgaagc tgttgattta 82620
ttagatgaag cggctgattt agttgaggat gaagaggcta gaaatagaat tgatgatgct 82680
atttcaggtt tagttgacgc agaaattgat atgaaacgtg aagctgatat aatccctgta 82740
acagaggcag ctcgtcgtgg attacaaggt caaccaggct ataaagatgg tatcgttagt 82800
gtagaaaacc tcaattataa aaaagcaagt aattctttat tgaaaaaaaa tgaagacgaa 82860
aaagaggagg aaaaggaatt ggatatcaaa aagaaaaaag aagaggaaat caaaaaagat 82920
ccagttactc aagaacctgt agaaaaggaa acaaaagtag aaactgaagt taatcccgaa 82980
gacaaaactg ctgaaactaa acaggtagaa gaaacaaaag aacctgtgag tcaagaagaa 83040
gaccaaccca gtgaagaagt tcaacctgga ggacagcctg gagcagagca gacagttgct 83100
aaaccagaga agacagcagt tgaaccagaa gcaacgggag ttcaaacaga tacagttgag 83160
gaagaagcag gacagcctgg agaggaagta caagaagacc ctcaaggagc aaccgctgct 83220
acaattgcag aagaacgtga aaccgctaaa gataaacgta cgagcgcttt attatctgat 83280
gttggcgata atgaattatt tgattatctt attgaacgtg tagctgccgc agatgaaatg 83340
cgtactaaac tacaagaaat gttgggaaca gctgtaccag aaggtttacc agaaggtgga 83400
gatgtaacag tcgaaggaga aacaactgaa gaagatttag gtactgaaac agtaagtact 83460
cctgcagatg ctacagaacc agaaattgat gttaaatctg acaaacctga ttcagaacta 83520
gctgctgaag gtgaagatat gactgatgaa gaaactcttc aagaagatgg taaagaagtt 83580
gttaaagccg ataaaactat tgaagttacc gatggtggag caactgacga aggtggggaa 83640
acttctccag caccagaaca ggcagaagaa aaatctgagg aatctgcacc agaagataaa 83700
actgtagttg aagaatcaga agaagaaaag aaaaagaaaa aattagatta tagtttagat 83760
tttaaagcta ttattgcaga aaatcaacaa ttaacagttg aaaacgaaaa tcttcgtcaa 83820
caaaacgaag cattgctaca atttaaacta aaagctgaac gtgaagcaaa agaaagctta 83880
ttattagaat ttagtctttc cgatgaagga aaagataaaa ttcgtgctaa atttgatgag 83940
ttaactttag aagaggttga agctcaagca gcattagcac aacaccgaga atttaaagaa 84000
gctcatggtg gtcaaaaaga gtctggtgaa ggtattcaat tttcacttga atcagaagaa 84060
actgaactag atgcgttaga tgaagaagat agtttagcgc ttttcttaga aaaagtttct 84120
aagaaaaata aacgttcacg tttttaattt aaaataggaa attatttcta tcaaaatatt 84180
gcaatcaagg tttacttatt ttcatttgaa aatgagtaaa ccacgcaata tttcaaaaat 84240
aaggaggaaa tagaaaatgg cacaacaatt attaaaaaaa gtcggctacg ggcaagttga 84300
gaaaaaccgt attcaaggta tccgagctgg tcgagtttta gcagacctac ctgttaaacc 84360
agaggttgtt aaatctagcg gagatcgtat tgaaaatggt atgttcttag atgcagttta 84420
tggcacaggt tttgaaggaa atttaaaaac tggtcaatta gaattgccaa cagcacaaag 84480
taaaaatgtt ggtttggtat atagtgaggt taaattatat agtgaatata cttcaaataa 84540
agattttgct ttatttacag taaacccttc tattaaccaa atgcgtcaag caccaattta 84600
tgacaaaaaa gaagctccaa aagctacagt tatccctcgt ttgattttcc caacgcctgg 84660
tgatatcttt actactaatt taatcgaaac ttctgatggt gaacttccag aagtaggaac 84720
aacattaaaa ttaaatgata aaggtatttt atctacagca ggaactttaa acgttgttat 84780
tgcaaaagta gttgaaaaaa caacaatggc tgatggacaa gttgcagcaa aacttgctat 84840
cgttgaagta aatccagcag ctacaggcgc gtaattagat aggaggaaat ggaaaaatga 84900
atttaaaacc tgaacaaatt agaactttaa tgttccaagc agcagacatt caaactggag 84960
aatctattga attctcagat aaatcatatg attctcatac attgaatgaa gctcttcgtg 85020
aagaaatgaa tagtttaatg ggaaatggtg gacatcgttt cacagctaac cgtgagttag 85080
tttatgcttt attatcagaa gtcgttgatg atttactacc taaacgagta tttgattcaa 85140
tgaatcgttt cgcagaaatt aaaaatgttg cagatggaga taaagtaaca tttaaacgtc 85200
gtaaaggtaa catccgtgga cgtaactttg tgacacaagt tgctcatgct ggtctatacg 85260
aagtattccg tctagacaga gaagtattcg atatgccaac aacagcttat ggtgctgctg 85320
taggattgga cttagaagaa ttcttagaag gtcgtattga ctttgcagaa ttaatccaat 85380
gcattactga aggctacgaa gaaattcttt ataaagaaat tctacgccat atggtagcgt 85440
taaactctaa cacaatttta cctgctaaca acatctatag tgtagctggt tggagcccac 85500
gtcgttttgc agcattactt ggtatttcaa gtgcttatgc aacaccaaca atctttactt 85560
catatgtatt tgctgctgaa atgatccctg aaggacattt agcaacagaa aaaatgaaag 85620
aagaatataa ccgtaatggt ttcatcggaa actataaagg tgctaacatt gttgtactac 85680
cacacagctt ctacaacgaa acaaacgaag cagaagcagt aacattacca ttaggtatgg 85740
cttggatcct tccagatgta gacaacaaac cagttaagat tgcttttgaa ggcggaatgc 85800
aaactaaaga agtagattta gacgactggt ctaaagaaat gcacttctac aaaaaaatgg 85860
gtactatgtt gatggctaac ccagctatct gtatctatga aaacactgcc cttaatgaat 85920
ggcctgtagt taacggacca attattaaag aaacagaagg caatgttaca ccaacatata 85980
cacgtttggt ttaatataaa aatccgaaga ggttcgagtt taagactcgg gccttttctt 86040
ttgctctttt ggggcatatt tgtttaagta tactttagtt agttctaaat agattagaac 86100
agagaaaaag gagagaaata aatatgaata attcatacct aactattgat tttagttatc 86160
ttgtcgaggg gttaaaagga gatacaatga ttcctgtctc aaatatgggg cgaaaaagag 86220
ttgcttatat cattgaagaa attggagtaa caagagattt tcgtcaattt caagaaggtc 86280
agcgaccaga tactaaaaat attccatttg gagaacttta tgctttaagt aatatgcctg 86340
gaggcatgca attaatttgg gacaacctaa aaattgatag caatgacgct cgtcaagctt 86400
taggattacc attagcagaa gatactccag aagtagaata tgaccgagaa actgtagcta 86460
acattgtaca aaaaggtaca gaagatgaaa tcttagacat gctagagttt ggtccttatt 86520
atattgcaga atggattaaa gaagaagcta ttaatgtaga tagttctaaa cgtcgtcatt 86580
ttattggaca agttctacaa attaatattg atgctcttga agagaacgtt aaatgggctg 86640
ctggggacga agatgctgga cgactacaat accaaacaat taaaggtgtt aaaactaata 86700
ctgctgcaag aagcgcagga cgtcgttcaa ctggaaaacg agcagaaggt aaaacaaaaa 86760
ctggaacagc aagctcaggg cgtaagcgca gaacataaaa ataagataaa atagaatggc 86820
tggcttacga gccagtcatt ttttttagga ggaaaaggaa atggagaatc aacaagttgg 86880
aacaagtttt tttgaaattt attgtcgttt tttagataaa atcactgatg atatgtattt 86940
agaattaagt cttgaagaca ctctaaaaat tattgaatct atttttatgg attccttacc 87000
agaatatagt tatccaagat ttagaattgg attatacgat ccagatattg ttacctctga 87060
tgctttagat gaagaaggga atccagttgt aacaggagcc ttcgttgata ctttaaccaa 87120
tgaagaaaaa gatattattg ctgaaattat gttattaaat tggttaagac gtcaattaaa 87180
tacaactcgt attattcaaa tgagatattc tacatctgat ttcaaacaaa cttcacaagc 87240
agcacatatg caaagattaa atgcagttat tttagaccaa caaaaacgta ttaaacataa 87300
attgaattta tactctaaac gtaaaattga taaagatggt tatattgttc ctaatgcgga 87360
taatctttct ggagttggtc cacgtgctcg ggatattatt atcacacagt taggagttgt 87420
aaaacgtcat gactaataca gaatttaaaa atggctttgg tattaatgaa gtaccatggg 87480
gaatatatat taaacaaaag aaaaatcaag tatttaaatt actacctctt aaagaagaaa 87540
atggcgaatg ggagaaacag ttacaaacta tcctacttga aatgggagga ataattaatt 87600
tatctcccca agaggaagta gttgctataa caattatggc taaattagct gggctcgaaa 87660
atgaaaatga ttttatgcta tatagaaaaa cagtatttga aattatctcg ctcttggagg 87720
actggaaaaa agaaaggagg tagttaataa atgaagatca ctgatattgg caaagcaaac 87780
aaagtaaaag ataatcatga ccatcgaata gagagtggct atcaagttaa acctagtgat 87840
cctgtagata caaatactgc ttgggactgt ttaaataatg caagaaaacg tatggatagt 87900
agtttaaagt taaatatgct agacaaaagt tttcaacaag cgttagattc agcagaagga 87960
acagaattgt ttacagtatg ggaaaaaggc gacactgacg tttggaaggt tatacttaaa 88020
aaccaaaaag ataattggca acaagatgtt aaatatatta atgctttgaa tggagtcggt 88080
tttgaagtag gtaatacagt aacttggcaa agacttggga ttagatggtt aattacatgg 88140
caagattata atataaatga atttttcaga ggagaaatcc aaaaagctga acatgtggtt 88200
agatggaaaa atcaacatgg acaaattcaa caacagtggg ctgtagttca aggaccgatt 88260
gaaactcgtg ctaaatatga acaaactaga ggaaatacta ttgtaggtcg tcaaaatgat 88320
actgtagaaa tatggatggg atctaatagt cctaaagacg ttaatgattt aacaagatat 88380
gataaaataa atattaaagg aagatgttgg agaattcaag taattgatga tatttctaat 88440
cctaatattt tacgtttttc atgcgttgaa gatttcaaca atccggtaac agatgatatg 88500
gtagctttaa ttcctaatgg taaaattgat tttgccccta acgaagaaga acctaaagaa 88560
aataaaattc gtattgttgc acctgctaag attaaagaaa aattagttag cagagtttat 88620
gcaattaatg aagagacgtc tgaaaaagtt aaaggaacat gggaaatttc tggcgcaacc 88680
tttaataagg tagatgaata cgaggtcgat gtaaaaggaa cgaaaattgg gaacataatt 88740
actataatgt ttacagacga agaaggaaat tctaatatag taacagctaa aacagtatct 88800
atgttttctt gataaaataa tgagttaaag gagagaattt taatatgcct atttatgata 88860
gtaaaaccaa aaaagctaca aaagatatgt atataaaaga tagatttatc acaagcggcg 88920
acaacctaaa tattattgct aatcgccttt tggatagcga cagattaatt aaattgctta 88980
ctcgcaatgg ttcagatgtt ttaacagatg acagacctgt tacagacgaa gaacgagctg 89040
aagcaatgag aactaatatt ggtgttatac caattataga taaagatatt gaagtaaata 89100
cttttattgc agtacaaatt actgatattg tgcctacaat acaaggatta acatataatt 89160
ttgtgtttga tattttgtgt aacatagaag tttggaattt agatggatat aaccaacgcc 89220
catatttaat aatgaatgaa ttagaccaac ttttttcaaa tactaagatg aaatctttag 89280
ggccagcaac attcttagga gcaactagct tgaaaattaa tgaaaaaatg cttggttata 89340
ctatgatgtt ttcattttcg gaaatacaat agtaatggat attttaacaa aagttgctgg 89400
cacagacttt tattttatac cttttgctac attaattcat caaccaacaa taaaagaaat 89460
agctttatta ggagaaaaaa ccctatttga tgccttagca atctttgcgg gttcttctcc 89520
agactatttt aaaaaacaag tacttaaagg aatgcccgaa gaagaacgtg gagcaacaga 89580
agttgaatta aattatacga taacatcaga gctagatgtt ttttataaat attgtttggg 89640
aactcaagaa aaaagagtaa ttgaatcctt tttattttta atttttgaat cattacgagg 89700
agtaaaattt attcccatag gagaaacaaa aatgttgctt caactatctt ttgtagatat 89760
tcttagcaaa gaagaaaata aaataaatac tattactctt gatgcagaaa atttctcaga 89820
attaaaagaa actatttctg atatgtttac ttatcaatca gaagaagatc aagaatcgaa 89880
actaaatcct gctggagaaa tggctcaaaa aattgctgat aaaatggctg cagcagcaga 89940
aagaagagct agaatttatg ggaaaagtaa ggctaaaaaa gacgaagagt ctgtaatagg 90000
aacaatggct tcaattttag ctacgagtga tggtatacca ataacagagg tcttaaaatt 90060
aacatttccg caggttctta ttcagttaaa tcgaacacaa atgttccaac aatatcgtac 90120
acagattaca cttggggctt ttggaggttt agaagcagat gatgtagtaa actggcaaca 90180
gtcagtttaa ttttactatc aaaactttat aatacaagct tggttttttc tagatgtatt 90240
agggaatata attccaagaa caactcatat aagaggagga aaaacaaatg aatgaaaaat 90300
ttggcgttcg agaaatagta gacgtagtat ttaaggctaa aagtgctatg actgttggta 90360
acactaagta taaaaaaggt gaaccagtta tctactttga ctcagctaaa acttcaactt 90420
tggagtctac aactgctact gtttacgctc aaggtggacg tggtaatgct cgtttacttg 90480
cttgggaagg tgacaaaaca gttactttca actttgaaga agctctatta tcaacacgta 90540
gttttgcttt gttatcaggt ggtaatttaa cagaaaatac tcgtgtaaat atgcacgtta 90600
cagaacgtgt agaagttaca aaagcatcta tccaattggg agaaaaaact gctgctgaag 90660
taccagtact tgatttagct ccatatctac ctaaaaatgg acaaatccta agtgctgcag 90720
accctacttt ggtaacagaa ggtggaaatc ctaaataccc tgaagctggt atttatgtaa 90780
tggaacttaa cgaacatggt gaaattactc gtcgttttga tgttacagca ggcgctttac 90840
aaacagctcc ttctacacca gctctatcta ctttggctga gtcacaacaa ggtgacgata 90900
ctgaattaaa tgtaactaaa aaattctatt tagcaagtgc ttatgctgga gatagtgcaa 90960
ctacagctgt ttcaggcgca aatgctttag atgagtctaa agtttactta gttgacttct 91020
atgtagctca accaggttca aacttgacaa tcacaccagg taaatttgca ggaagcttct 91080
taatcgaagc aacaacattg ttccgtcgtc aagctgatgg acgtgacttc ccagctcaat 91140
ttactattcc aaatggtaaa atcagttcta acttcacatt cacaatggca tctactggtg 91200
atccaagtac attcccattc caagttgaag cacaacctga ttatcttcca tttaacaaaa 91260
aatgtaaagc attatttgca ttggatgttg ccgaagaacc aattggcgaa gatgtgtgct 91320
aataattata aaagacctag tatttttact aggtcttttt tttgtaagta attcatattt 91380
tttattattg ataaagacat acgagaaaaa ggagagaaat atactatgag taaaatatct 91440
tttagtaaac ttaaattaaa ggttgatgat agtgtcaaca ctgtagagat tgaaggtgca 91500
gatggtacaa tttatgagat tgaagtaaaa caatatcttc caattgaaaa caagattaaa 91560
cttgtttctt atgtaattgc gaaatctgcg aatggtggcg ttattcgaga agatatgcta 91620
gatgcctatc ttggtgtaga attagttaaa gaatatacta atttttcatt tacagaaaaa 91680
atgctccaga atgatgcaga tttatttgat gtactggaat ctaatgatat tgtgggtaaa 91740
gtacaagatg caatgaaccc tgcagaatta gaagacatta ttcgttatat taattcttat 91800
tcagaccaaa tgcaaaaatc tattcaatct tctgtatcag gatatactgc tcaagagaaa 91860
gctattgaag gcatggtagc taaatttatg agtgaaattg tcagcaacga atcagaaaca 91920
gtgtcagata actaacatta caccttctta tcacaaggag gaatgagtac gaatgtcttt 91980
atcagatgtt ttaaatgcgg ctcctggttt gtcagattta acgattggaa tagttgctat 92040
ccttttggta gtctggttag ttgggaaatt tttagataaa caacaagaac aaactatgtt 92100
acacaacgaa caaatggaca aaacgttcaa aattatagca agttttaccg aaacattatc 92160
tgaactagtc gcacttatcc gagaaggaaa tgaaaagaca gacaacgttt ccgataaagt 92220
tgatgaaata aatcgtaagc tagaacactt tgaaattcat gacgaaaaag agcatagcga 92280
gaaaaaacaa ggagacagga acgatagtta atctatctcc tgtctctatt tttatcccaa 92340
aaggagggaa taggatggcc gataatctgc caaagttacc ttatacgtta caaaacatac 92400
gagacttaaa atttaattct gtctataatt tacagccttt acaatcatac tctttaagag 92460
attttaattc aggcgataca aagcatagaa tatatcaaaa ttatattaat gcttatgaag 92520
cagattttac ttctagggca ggaatgaatg ccgaagaatt ttctaaaaaa gctggtcttc 92580
atagtaaatt agttacagaa aatacagatt ttattaaaaa ttttaaaata gcacaaaata 92640
atttcagtat aaataataca gagttaaaca aatatgttaa tgatttatta tctggagatt 92700
cagatagact acaaaaatta gctggcaaag aaaaagaaat tattaaagta ttagaaaatt 92760
gggctaactc agttcaagaa tatcttgatg tactttcggg ggtagatgat ttatattatt 92820
ttagaaatat ggatcaagct cagataaatg gttctatttc tatggcaagt ggaagaaata 92880
tttctcaagc ctttagatta gaacgaggtg ctatgacagc gatgcaaaat gcagacgctt 92940
tgatagtagg tttaaaacaa tctattgata aaatgaatca agaaggatta tctgttaaac 93000
aattatcaaa tatggttatt acaactccta gttatgaagg agctaaagga caagcaccat 93060
caacaataaa aacattggga aatttaaaga caatggttgg gtcattgagt aatttaatgg 93120
gttttgcctt cgaagcacaa ttagcaagtg gtttggaacg ccaagtcaat gaagcactat 93180
ctgacattgc cctcttggga ggagcagaag gagtttcggt aaccttgagt gatggacgac 93240
cttttaaagt taaacaaagt aaaacagacc ttagagcaac tgttgaaggg attgacttag 93300
gtttttcttt aaagaattta tctaaaaatg gtaaaactaa acgagtttca ttaaatactt 93360
ctaatacaaa tcagcttatt gctttaataa gtaataatca agatttccga tcacagttag 93420
ctggaacact aatgtggcgt tctaattcta taaaacgaac tcgtgaccaa ttaacaatgt 93480
ttttagcttc cttgtctgca gactatgcaa ttgcaatggg aggaaatgat cgtattgatt 93540
atatggtttt taatgacaaa gttattagct taggagagta ttattcaatt atggagaaaa 93600
gattatctct taaaattcat cctagtgcta gtcagagttc ttatcaaaat caacttagag 93660
agttgagaga acgggaaata ttagctaata tgcctgttaa atttacaaca tagagagcaa 93720
aaggagagga attaaatggc aaataatgta gacgttggtt taaagtttaa aactacctac 93780
gaaggtcttg atgccggtaa acaggaccta aaagagctaa aaaacttaat ggactccatt 93840
ggtaaagatg gagttaaact taacttaaaa gatggagaaa ttgaacaagc taaattacaa 93900
atttcagctt tggagcgctc aattagagaa gctgaacaaa gtggtggaga ttttggtaga 93960
attttccagt ctaatttaaa tgcggtacaa aatgaagcta aacaaactgc aactagtgtt 94020
tcaaaggtag agaaagaaat taaatcttta aaccaaacat ctaataatgg tggaggattt 94080
aaatctatct ctaacgctgc tcgtctagca acaaaagaaa ttcaaggaac aacaggtcaa 94140
attgatcagt tacgaatgaa tttacaacaa ggtatgggac aaactattgc ttttggtgct 94200
attggagctg tgacaggcgc agtaaccgat gctttaaatg taacaaaaca attagatgaa 94260
atttcaacag atattagtat cgtttctggt aaaactagaa aagaaatgga aggatatcgt 94320
gatgccgctg tagatgctgc tgatgcctta ggaaccacta caaaagatta tttagatgct 94380
tctttaatct ttgaacaaca aggtggtcaa gcagcttatt acgcaaaaga attagcagaa 94440
gctactgtaa cagccgctaa tatttctaac gtagcaacgg atcaaatgtc tgaatatctt 94500
acagctacaa ttaatggttt ccaactatta aaagaaaaag gtggagaagc tggtacttat 94560
attactgatg taatggctaa attaggagca gcatctggtt ccgacttagc tgaaattgct 94620
acaggtttaa cacgtactgc taatacagca aaagacgttg gttttgaatt tgaagaaata 94680
gcaacaatga ttgctactgt ttctgaagta actcgtcgta cgccagaaac aatcggtaat 94740
gcatttaaat caatgcttac ttcgttcacc caattacgtg aagctggaga agaagaagta 94800
gaagctttca caaataaagt tcaagaagct tttaaacttg gtggaattga agatatttct 94860
ttatttgata atgggaatct aagagatgct tcagatatct ttaaagatat tgctgctcgt 94920
tggcaaacaa tgaataaaga acaacaatct ttagtttctg aagctgttgc tggtaagtat 94980
caagcagaaa ctttccgtgc gtttatgaac aaccaagagc gatacaatca attacttggg 95040
gaagcttatg attctgctgg aacatcggcg caacaacaat tagtatatat ggactcttta 95100
aaagctaaag gagaacaact taaaaatgct tggcagggcg ctgtaaatac agttgttgac 95160
tcagatatgt ttaagggtgt tttggaagac gctactaatt tcttaaaaat tattggtgac 95220
gcaaaaagtg gacttggtgg tttagctaca gcaattgctc ctattgttgg tattggcgga 95280
caaatgtttg gcgctaatca ggttggagaa ctttattcca ataatagact aaataaacaa 95340
gccaaagaaa ttacagcaag tttagagaaa atgaaaattg cacaagaagg taatttgact 95400
gcgttacaag aagaatacaa atctgcagca gaagtgaacc agattatgtc tactcttggt 95460
ccagaggctg cgagaaacta tgaagaagta actaaagaaa ttactaaact tgatgaaaaa 95520
ttaaaagata ttccgaaaaa tgctgaagag gtaaagaaaa aagctgaaga agctgcacaa 95580
gcgattaaat taaatggtta ttataagggt gtagacgaaa aaaatgttac tagagcagca 95640
aaaggattag aaaatgaagg taaagacgct cgaattttag aaaatattac caaattaaat 95700
aaagctagag aagagttaca aagagcagaa caagtatcac ttaataatct ttctacttta 95760
gaaggagcag ttagtttact tgattctaaa gcttctggag ttagaaaaga actgcaagaa 95820
gaattagttt tatgggaaga tgatattcga agcgctttat atgaaaatga aaagttatct 95880
aaacaattta ctggagacct tgataaaatt cgacaaggaa tagatagcca atatgatagt 95940
catgccagcc ttttaaagat tcgtaaggaa gctaaagtta tagaaaatca aattcgagat 96000
gcaatgatgg ctgaagaata taatgccagg gaaaatgtta ctaaagctga aaaagaatta 96060
gaaagcaaag ctaaaaaagt agtattagaa gaacaatata ctaatgaaat gaaagaacaa 96120
aataaaatta ttgctgatag aaaagtatta gaagacaaag ctcaaagtac tgctcaaatt 96180
gcaaaacgaa cagaattaat tcaaaaaggt gttagaggaa tgagtttggc ttatagcaca 96240
atagttccta ttatagctac ctataattct gttcaagaaa aaagtattag caaacaagat 96300
ggtgtaattg caggtttaca aactacttct gcaatgttaa tggcatctat gaatccgtgg 96360
ggtatggctg caggggccgc tgctggagca ttttccttaa tagttgataa atttgactta 96420
ttcaaatctc gtggagaaaa agcaaaagaa gttaatgaac aattgactaa aacttttatg 96480
tctcttcaag aaacagttaa tgggaatatt tctaacttaa atgatattgc agatacctat 96540
aaacgttttg agggtgttaa tgctgaagca tttattaata atgcaccaga cccaagtgat 96600
acagaagctt ttgaaaagta caataaaaat ctagaagatt atgataattt agctggtaaa 96660
attgctcaaa caaatccaga attagtcaaa ggttacgatg atactggtag agcaattata 96720
gatctatcta aagattttga aactttgatg gagcaacaaa aaactgctag aacagataat 96780
tatcaaatgc tttccgcaaa tagaaattca tttattgtac aacaagtttc tgacttacaa 96840
aatgctaaat ctagtatgaa tgattattct gttgaagttg ctaaattaac caaagaactt 96900
gaaaatgcaa aaaaacaggg caaaggtgaa aaagtagatg atattctaaa agatttaact 96960
aatgctcaaa ataaaatttc agaagtacaa aaaaccttca gtgaaactaa agctaatatt 97020
caaagtagta ttgtagtacc ttttaatgaa gcaaacgatg aatttaataa attagttgac 97080
aaagctcctg aattaaaaga agcatttgaa actttttctg atacttatat gaactctaat 97140
ttcctatcag gaatggcatc tgagaatgac gaagaaggaa tgaaaaatct tgttcaaaat 97200
atgggtctta ttaaagatga gtttactgaa atagctcaac aagaccctaa aaaagctcaa 97260
gaattcttag ataaaattgc caattctagt gaatgggcta aattagcttt atatgatgtt 97320
caaggaaata ttgaaacttt acaagaaaaa atgtcggaag ccacagatcc aattacagat 97380
gaagtacagt ctcaagcatt aaaatttgta gataaaataa ttccagagga agatgttgaa 97440
gaagcccaaa aacgtattgg agagcttgct tcagatctcg aagaaaaagt tgaagacgcc 97500
aataaaatga aatttgattt ttctaaagca gaaggcgctg actttactga ggatagaaaa 97560
gaaatcgaaa atattaatga taaaattaaa gattacgatg aacttcaaaa tacaatgtat 97620
gatgtttctg aaaaatacgc tagaatgtct aggactgtta aaggttttaa tgaaagtcta 97680
agtgatgttc aagatttaaa tactgcaatg gaagcattaa aaaatcttca aaaaaatggt 97740
tttgacgaaa gccaattaga aatattaaaa caaaaattcc ctgaactaga aaaaactatg 97800
agagtttctg ctgagaaagg tactgaggct tttcaaaaaa atgcttcaga tttatatacc 97860
ttcctatcag aaaggcaaca agccgctata actggtatgg tcatgaataa tgagcagttt 97920
tatggagtat ggatgcaaaa taattctaag acaattaata aaattgctga agattatggc 97980
attgatgcat ctaactacca aacgttggct gaatataaaa atgctctaca atcactaagt 98040
cttgaaaacc tacaagttat tgcaggagaa gaagtaaaag agaatgataa aaaaaataaa 98100
gaaattttag ctggggaagc agttcatgta agtaatatga tttctttaac cgacatctgg 98160
tctaattcaa atcttactta ctcccaaaaa cttgtagctt catttttaaa tgcttatgac 98220
gatatggcta atggactagg aaacgcctta agttatatgg aacagcttct aaaaggatgg 98280
ttaaatacag ctcataaagc attaggtgat ttttttggag gtatggtaaa aaaacttcca 98340
aaaggaatga gggacgctct tggtcttgat gagatagaca aatggggcga aggtggagtt 98400
tctgaaagct tctttaaaaa attagatcct tccactttag caaaagatta tgtagataaa 98460
aagaataaag aagctcaaga tgaacaagag aaaaaagatt ctttgattca acaaattctt 98520
gaaggtaaat tcaagaataa gaacggtctc tcaaatgaag acttgatgaa aaagttagat 98580
cttaataaac cacagtcatt agaaggtctg aatggtgttc ctagagaccc agaaaataaa 98640
gatgttgaaa aagatggcaa aattgaaaag gaagacaaag ataaggataa aaaagatgtt 98700
gataatctag aattagaatt agatagatat tacaaattag atcacatctt aagtgaaatt 98760
gaaaaacgtt attctgaatt atcagatgct aaagatgctg cttatggtaa tgatagatta 98820
aatatcatga agcaagaaga gcaattatta gctcaaaaag caggagtatt aaaacaatat 98880
acggctgaat taaataaaga gcaagacgaa ttacgaaata aacttgcctc tcaaggattt 98940
tctttttcag caaatggaga tattgataat ctaaatcaaa ggttaactga tttgcaaaac 99000
gctgcaaatt ctaaaaccgg agacgctaaa gaagatgcaa ttgacgctgt taaaaagatt 99060
caagaagagg cttcacgtta ccaagatatt acatttaatt taattccaga taaacagaaa 99120
acattaaatg aaattaaaaa acaactttct gaaattgcta gagaaagaat tgaatatact 99180
gttaaactta gagttgacaa agatgaattc aaatctgatg ttctagatgt tgttaaagaa 99240
atgcaagatt cttatgcaga ccttgatgaa aaagctcaaa ttgtcggcaa agaaatgaaa 99300
caagctttag ataatgtttc ttattggcaa tctatgatga atcaagttag aaacgaccgt 99360
ggtttaacag attctgacag acaagattta ttacaagaat acaataaaaa cttgctcgat 99420
gcagtttcaa aagcaagaag tggttataaa gaattattag aagtacaagc tgattttgtt 99480
aaacaatcag ttgaagctat taataaggta aatgatagat atgataattt atttgaaaaa 99540
gctggacaac tagcagctaa aacagaagag ttatatggta caaaagctta tggtaaaatt 99600
gttggttatt tcgataccca agagaaggcg attaatggtc aggttaaaaa tcttcaggaa 99660
gctcaacgta gaatgattaa atatcgaaat tctgttaaac aagggtcaga tgcttggaat 99720
gaggcaaatg atgctattaa cgaaatggct gattcaatta gcgatgcttt attgaaaaaa 99780
cttgagttag ctcaaaaacg ttttgaatta ttcactcaat cagttgagaa tggattccaa 99840
aaaatgtttg gtgcttgggg attagatgga gtcattgatg attttgataa acttactgaa 99900
aaacaagata aatatttcag caactttgaa aaatttacaa atatcagtag taaaatcaaa 99960
gaaattaacg acgaaattgc taaaacacaa gaccctaaac gcgccaaaga attagcagac 100020
tttagagata aagaattatc cgctctcttg gctcaagata aagtttcaca agatgattat 100080
gatcgtgcaa tgaaaatgta tgatattaaa caaaaagaat tagctttaca agaacgagaa 100140
aatgcaaaac gtacagctca attagttcgt gatgctaatg gtaacatgac ttatgaatat 100200
gttagaactg aaacagaaga tttatcaagt gaaatcgcag acttacagaa acaaaaagat 100260
gaattatatg cttttgattc tgataaagta aaagaatctg ctaaaggtgt atttgatact 100320
atttctaaat accaagataa aataaaagaa ttacaagata aaggattaga tcctgcagaa 100380
tataagaaag agttacaaaa acttcttgat gaagcagaag atgaaattaa agataaaact 100440
aatgaaatga ataaatggtt agaaaatgct ggaaaagatg gattaagtaa tctacaaggt 100500
atggttgcaa atggtacgat tacaccagat caactaggag tagataaaaa tacgttatca 100560
agtattttct cagcaatgaa agatggtact ttaacagtac aagatatgtt aagcggagac 100620
tttgatgatt ttgcaagttc tattggtatg acagccgatg aacttagtgg tacaatggat 100680
aaattattag aattaatctt aggagataac atggatattg cagaagcaat gatggacgca 100740
agcaataaat ggacttctac tgctcaacaa aatgtaaata acttaggaaa tgcttatgct 100800
gagtatatgt ctcaagctac aaaagtttta aatgattata gcagctctac aggaagatta 100860
aatgatttgt taaaccaaac aaatcaagct tctcaacaag ttatttcaac tattgataaa 100920
caaactcagg caatgctaag aagtcaaaga caaactgatg caacatcaaa tagtgtttta 100980
aatcttcaaa atagattaat tggttcaaat ggaaattcag gactgtttgg ttcaatggtt 101040
caattgcaac gtactatgaa tgagcaatta caaccttcaa tgataaacac tggcaaacag 101100
accgatatat taagtgggaa aacttataat tcagcagtaa aatataatgc aatgggaaac 101160
gaagctaaat tcgcttacca acgagttaac gcatttagtg accaacctac aaaagtagcg 101220
atgtcaaata ttgatagaat tactggtaaa accaataata ctgctggagc atttagaaat 101280
gttaaacgtg atgcaaatga aggtagaaat agtattattg acttcagttc agcaattagt 101340
actttagctg gatatggttc ttataaagtt tctgagggct ctaagaagaa agctgcttca 101400
ctagatagtg gaggttatac aggaacatgg agtaattcaa caaataatgc tgagggtaga 101460
atggcaattt tacatgaaaa agaattaatt cttaataaag aagatacaaa aaatatttta 101520
gaatcagtta aaatgcaaag aggactaatg gaatctatta agggcagagg ctcttctgta 101580
aaaaatagta ttcaaaatat gagttctaat atttctaata ttcaaaatag taacagaatg 101640
agtacagttg aacaaaacat tactctttca ccaaacttcc ctaatgctag agatcgaagt 101700
gaaattgaag cagcgttcga aggcttatta ggcaaagcat caacttatgt tggaaagaaa 101760
tagaatataa aaactagggg cggaaatacg actattttcg ccctttcttt ttaatctcaa 101820
taggaaaaaa gagaaaaagg agctgacatg atatggataa aagccaagag ctttttgatg 101880
cgattcgatt aattgcaagg aacgaaatag aaaaacaatc atccacagat actgtgattg 101940
gtacagtaat tgaacgtgtt gaatcaagcg acgcttataa agtttcttat caaaatattg 102000
aaattctagc aagttctatg ggtggacgat ataatgctgg agattctgta tatgtaatgc 102060
ttcctaaagg aagattagat ggggtcaaat ttattattgg taaaaccaat gataggactc 102120
cgactataac aacaaatgca aatggactat ccgattctac tcttggtatg attcaggata 102180
ttattaacaa ttttaacgat ttaatttcag ataataaagt tactccagta gaaaaacaat 102240
ctttacaagt tcaatgggaa caaattaaaa agtcttatca agagatttta aataattctg 102300
caccttatcc agaaattgat ttaactggtt taaattctaa atataaaact ttagaatcat 102360
taatgaatgt tattttagga aatatggaaa ctactacaga ggttgatgga aatacagtaa 102420
gacaagtttt atctaattat ttaactgaag atacctcagt aagagtttta atccaagagg 102480
cactaagaaa tgaaattact tataaagctg atattgtttc tacaaatggt gaaagtttta 102540
aaaatggtgt aattaatact attttaaaag taattgctat gagaggtaaa aaaactataa 102600
cttcatcatt tgagccagaa aatattagat ggtataaaat gaaagatgat ggttctattt 102660
tacctaattg gtctaggact ggtaaaagta tccctattac atcagaggat gttgacatta 102720
aacaagtatt tgtggtacaa ttatatgtag aagaagcaat ggtagcacaa gatacaataa 102780
ctatagttga tttaaatgat atagaaaata ttaaattaag tttaactcct aagttaagta 102840
gaactcaaac gtttgaccca accactaaaa atattatacc agattatact atacaaaatc 102900
aagtcattca agccaagact ctaaaaggag cagatgatat tacttcttta gtaacgcatc 102960
aatggtatta taatggagaa ttaattacca atgatggtag gtttgaagtt caaaacaacg 103020
ctttgtttat caaaagaaat ttaatggact cagaaaatcc tacaatgatg attgattgta 103080
gagtatctta ttatagtgaa gaatataatt taacccttga ggattctttg tctttagact 103140
tctcttatgt atctaatgga gaagatggag aggatggaaa gaatgctctt ttagttaacg 103200
ttcttcatcc atatggcaca accatcaaga ataaacaaca atctcttctc ttggtatcac 103260
tacaagcata ttttgctgat aaagatgttc tttctttatt aagcaataga aaatggtttt 103320
atgcagatga atcagttaat tcttctagtc cttattatga taaagatggt ggagtaggct 103380
ggtctctaat tagcgagaca aataatttga atggagcttt aaatggatat gatacaaata 103440
tcctatctat ttctggaaat ggctttaacg gcagcatttc tatcaaggtg gtagcttact 103500
ttgaagaatt taaaggagct gcaacaacta ctttaattga ttctactgat ccaattacag 103560
gagttatctt gggcaatacg caattaaaaa atggtgagcc aacttcatta caaatagaag 103620
cttatttagg acaaatgaaa ataacagata cttctaatta cacttttgtg tggaatttag 103680
aattggtaga taatagttct agaataattg gtccaatgga acctttcact aaaacgacag 103740
tatggcccaa gtatggagaa tctattatat tagaatgggg agatatccct gaaaacgata 103800
atgtttatgt aacatgtaaa atatatcgta atgagtagat aaatatagag ataaaggagg 103860
gaacaagatg tcattaactc aagtaggtac agcttctgct ggtatttcaa aagtaattga 103920
cggacaaagt caatatatat tctggagatt ttcagcaaac ccagatggaa atcctatgac 103980
agaaagacca acagaagata caaaatatat gggggtttat acaagcacaa aaaataaacc 104040
ttccgagaac ccaagtgatt atatctggac taaaattaag ggtgaagatg gttcagatgg 104100
acaaaattct tatagtggtc tcttaactga tgaatttatt gctgttaata cagatgcaga 104160
tgggaataat ggtaatttct ctaatgctag tacgtcaatt attttgtttg aaggaacaag 104220
agaaaataca tcagagtggg atatttctgt tgaagtaact gcaggaattc aagggagttt 104280
aagttcttca aaggacactt ataaagtatc aggaatgact gtagactcag gagaaataac 104340
ttttattgct aggtataaaa caactacttt gacaaaagta gctaagattg caaaagtaaa 104400
acaagggact cctggagaag atggggagag tccatacaac gtagaactta tatcatcaaa 104460
tggtttaatt tttaaaaatg gggtaatttc aacaattatt catgcgatcg tttttaaagg 104520
aaatgaaaat attactgatt tattagacgc gaatcagttt agatggacta aaacaaatgc 104580
tgatggatca ccagatttaa tatggaatgc aatgcatgct ggtggtacaa aaagcataat 104640
aattgaaaca gatgatgtta acaaacgtgc aacatttagc tgtgacatta tcgaagagat 104700
ataaaggaga tggaataata atggcaacaa tttcaagcgg tcaaattaca attattgatt 104760
tatatgatgc tcctgcatta aatgcgtgga tttcagcaag tcaaacaaca actcaaacat 104820
acaacaatac aactaactca tatacaccta attttgggtc ctctgcacag gttttaacac 104880
ttaacttaac aaaagcaggt ggaacaggaa gtttaattgg ttctgctgta tcaggcgtta 104940
aatggaaaaa aacagtaggg tcaacaacta ctgaaataac ttctacaaca aatactgata 105000
gtgaatataa gagcggtaca tcaaacagtg tgttaacaac aaaagtaaac gttccaacaa 105060
cagataatgc tgtacgttgg acagttgaag gagtatatac agacccagat acttcgctac 105120
caattacttt ccaagcgact atcgacatta ctcttgttca actagctaaa gctgcggtag 105180
tagcagtttt gagtacacct aatggaaact acttccgaaa taatacgcct tctagtctga 105240
agttaaccgc tgatgtttat aaggatggaa acttaagcaa tggctctcga aaatataaat 105300
ggttcgcagc agattcaagc gttgtaacat ctcaagattc tgacgctgga gttggctgga 105360
gaaaaattac agcaactaca ggaacatcag gagctgttgc aaattcagga tttgatactg 105420
cagttacagt tcagggggtt ctaacggtct atccagacgc agtaacaaat ggacaaacat 105480
tcctgtgtgt cgtcacagat aatgttggag gaacttctgg aactaaaatg aagcagtatg 105540
taaccttgat ggatatggac gacccaatta tggtagtcat tgagtcctcc ggagggaaca 105600
ttttgaagaa tggcgtaggg tctactactt tgaaagcacg attgtatcaa aatggtgaag 105660
aaatcgattc aggcggcaca ggctatactt ataaatggtc taagtggcag aataatgtaa 105720
tggtaccaaa cttcggcggg acaagtaatg cttataaaac tgggaaatcg ctgtcagttg 105780
gaagtgctga tgtaaataat tcaacaacgt ttaaagtgga ggtagaaagc aaatgacaaa 105840
ctacattgct tatatcattt taaataatga acggacaaaa attgaattta gtacagatag 105900
gaatcctatt gaatatttgt ggactaagta cggcatggat acgtatatcg aatccttcga 105960
ggaaatcaaa gaagagggtg attagatggc tacagtttca cgtggtgaaa tcactataac 106020
aaacgttaat gacggacgta ctccatactt ccacacggct tataccaaca gcactgactt 106080
tggtagttac gactactccg gaaatcctaa cttaatggtt ccattgaaag ctagtgattt 106140
ttatccacaa tctggggcta ctatagaaga ctatagggat gccttaaaag taactttcac 106200
taaaactgat ggggctgttt ttttaggaac tagcacaaat attccagctt tattgccaaa 106260
tactcaatat acattaagcg cagatgttac tgtttctgag ggatacacag gaaaactaga 106320
aaatttaagg ttagggtata ggaaatttcc tggcggaaca attatattac cactgacagc 106380
taaagatgcg gttgtgggtc agaagactag aatatctata acagctaatt ctagcgctgc 106440
aacagactca tcaaagtttg atagaatgta cttcacaatc aatacaacat caacagagcc 106500
atttgtcgga acggctttaa tcgaaaatat taaagttgag caaggaacag ctgccacacc 106560
ttaccaacct aacatcaaag gtgccccatg gtactttagt actgtttctt taggtaagaa 106620
tttgataacg aatgctcagt tcccaattaa aacatcaaat gaccctattg ctgggtttga 106680
tattttagaa gaattaacaa taggcgaaac ttatacggta tctttaaaag ggactaagct 106740
agctgataaa gaatttcaat tatactatgg agacgctggt aactaccaag caactttacg 106800
ccctgtggaa ggtctaacag atgtgtggag tgccactttt acagccagca attctactgg 106860
aacgtcaaat ttacgtaggg tagctttatg gcaaaaacct aattctgtaa caaatggtaa 106920
tgttcaaatt gactggctca agattgaaaa aggagataca agaactccta acatcgataa 106980
ttataactac ctaggaaact atactgactt cgttcaagca gactcgctta accctactaa 107040
gtacgcttgg agccttatca aaggtacaga tggagaaact tctcacatac acacagctta 107100
cgcttggtct gctgacggta ctgacaggtt tactaaagtt taccctcagg tcaacctgtt 107160
agagaacact aagaacccta ttagctccaa aacagttaga gtgaaaggtt ctacacactc 107220
aaacactgat gatgtaactt tcaaaagcgg tataacacac caagaaagaa aacccaatta 107280
tccaatcgga gaaatgtatt atagatttat gagtacagct gatggtaact tggcttctac 107340
taatctggta aagggggaga cttactatct tggtttagat ttgagagccg aactagctga 107400
gggagattac gttacatgga gagctcagta taaaaaatcc acaggaagct ggattgatgt 107460
tgatggttgg aaaactggag tatccaaaat cgagggagtt acttccgagt ttaaacgctt 107520
tgaaaatgct ttgacaatcc cgaaagatgc tgtaaccctg tacttctctt atcaagtata 107580
ccctaaatcc ggaaaaggtg ttgcaacagg ttcaatagtg gagttcaaga atgctaaatt 107640
tgctttgaag agtgctaccc catacactcc tactcccgaa gaagactatg agaatgctta 107700
tccgtcatac actggaacat actctgactt caatgtgaaa ggtagcgaca accctaagga 107760
ctacacttgg gcacgttcta tgggctctga cggtgaatct gcaaaaacat taattttatc 107820
aacttcttca aatactgtta aaattaatca agattcttct atccaatcag acactataac 107880
tcttcaagct aatatgcaaa atatgacagg aattgctact ttcagcgcca ctccatatat 107940
tggagcaaga ccacaaacag caataacatt gggcgggaca ggaaatacaa gaacattttc 108000
tacttcctct tggaataaaa attggacttc tttggtagtt actgctacat ttgaatcatt 108060
tattgataag caaacaatta tttctgttag agaaggtaaa gatggtgctg attcaataac 108120
tgggttatta acaaatgaat ctgtaacatt acctgctgat aaaaatggta ttgttgagag 108180
cttctcagag gcctcaggaa cgtttaaggt atttgatgga ttatcagatg ttactggtag 108240
aaacgttgtt tatacattaa agaataagtc aggaggaacc tttaatatta atgcttctac 108300
tggagtatat aatatgactg aaatgagcaa agattctgct atagcagtct ttgaagctac 108360
ttataaaaat attaaaattg aaaaaatatt aagtgtagct aaatctaaag caggaaaaga 108420
aacttatacc tatacaaaat attctaattc aaaagatttt ggaaattatg actattcagg 108480
gaatcctaat attgcaccaa taattaatga tgataatgta aaatcattaa ataatagtat 108540
gactactgtt acaaatcatg ggacttatgc aacagcagaa aaaattggaa atgatttaac 108600
tgtaggtgta ggtatgttcc catggtctcg atatgatttt agtaaattaa ctgtaggaaa 108660
acaatatact ttaactatac ctataagaat caatgaatca tataatggag atatttctag 108720
attatttatt agactgagat gtttagacaa agataataat gctctaatta ttattactgt 108780
aatggtgccc aaaaacaccc caaaaggtgt atttacgaat atatcagcga catttaatgt 108840
tcaagcatca acacaagtat ctcattcttg gtatgcacaa gttgggtcta gcacggacta 108900
tagttctaga ggctcaatcg atattggtta tgaagttaag ttagaagaag gtgctgtatc 108960
tacaccatat cagcctaact tacttgatga accgtattat ttgagtaagg tggctttggg 109020
tgaaaatcta attaaaccag aatcacaaca accagttact aatagtaact atcttattaa 109080
aatctataac accaaaccaa tggtaaaagg caagaagtat accatcacac tggaaggaac 109140
taagccagca acacaggttt ttagaccatt ttttacgcaa gctacaggaa gtccatgggg 109200
ttttggtgat ttgaagccag tagaagggtt aactgatatt tggtctgcaa catttaccgc 109260
aagtactgat tcacacccta ctagcccaca agtgcagatt tatcaggtac caaacacaac 109320
tgtaggacaa tgtacaatta agtgggtaaa actagaggaa ggcgacacac gaacaccaaa 109380
tattgattca tataaatata tgggaatcta tgttggggga gaaagcgaac aacctcataa 109440
tccaactcaa tatgcctgga gtcagattaa aggtaacgat tctacgtctt attcattatt 109500
attaagcagc caagtaatgt cattaccaag aggagcaagt aaactagttc ctgaaaatat 109560
tactatttct ggtatggctc aaacaggtga aaaatctatt gagaacatta aatctcgtat 109620
tgttgtagaa gaaactacta atggaactac atggactact aagtatgatg cagacgcatt 109680
aacttatact tatactcctt cttcattaaa cgttttatct gcacgagtta agatgtatgt 109740
tgctggagct aaaaatgtac aattagatca aaagagtatt aatattgtca aagatggttc 109800
gaacggttct aatggttcta atggttcaag tagttataca tggattcgtt attcagaaaa 109860
tgccaatggt aatccaatga ctacaacacc taatagtaaa actaaataca ttggtattgc 109920
tattacccaa acttcaactg cgccaagcgc ctatagtagt tacacttgga gtagaatcaa 109980
gggaagtggc ggacttgtag ctaaagttta ttctaatggt ggaacaaaca ttgaacaatc 110040
tccaattcaa attaatgtag aaacacaatc tgatggagat atagtagaac caaataaagt 110100
aacatggtat atgtcaaaag attcttcagc agaatggaca gcaattactg ctggaaatgg 110160
aattacctta aataaaaaat atatagttgt tgaaccagta gtattcttag aatcaaattc 110220
aattagtttt aaagctcaag tagaatataa ttctatgaca gcttttgact atatgactgt 110280
gaataataaa agcttcgatg caacgaaacc attaatttta cgacaaccag ctgctccact 110340
taatccttat cctggattat tatggctaga tacttctagt ggtagtggtg accctctaga 110400
taaaactaat ccaagcttag tttatcgttg gggtaaatca gccattgaaa gtgtaaatgg 110460
aactgaatat gcacattatg cttatgcaaa tacgccaact ggataccagg aagatggtgt 110520
tacaccagac ccaagtttta gtgttactta taatagtagc caaaaaccta tgtatattgg 110580
acattgcgta acagatacag cgtcagatcc aactactcct agttcttata attggaagtc 110640
aatcactaca gaaaatggta gcgaagacgt taatagtgcc aaaggtattg cacaagaaaa 110700
aatagaaaca acttacgcat ggggatgggt tgttctaagt gcttctgatt tagaaatgct 110760
tccatggcta aataatgaag acggttctac aattattgac tggatttatc aaattactca 110820
aaaaacttct gatgattcta ttgttcaaac tgtagttggt tcagaagata tgtcgaaagt 110880
atatgctaaa actgatgcgg ttgatgagct aagtagtgcc aaccatgaat tatcagataa 110940
aatagaagaa tataataagc agatgcaaga cgcttttgct ggaattgata caacgtatgt 111000
aaacaaatca gaatttgaac aagagatgaa taaattcaat tttggtattg ataaagctgg 111060
tggggttaac ttaattagaa actcaacagg tttccaatgg gaagatacag cacctagcga 111120
tgaaatgtta acaaatccta aatttgaagg aacaatctca actactgtta ctggattaaa 111180
taataatggt tgggtgtata atggcgcagg cataggtcaa gttataggag cagaaagtga 111240
tttcccagaa aacaaaatta tgcgtattgg tggaacaaat tcaccaacta aatacagcta 111300
tagtaaagac attcctgtct cgccaggaca gttaattaat atttctgggc aagtacgtat 111360
tccaaataca atcggaaata ctaaaaatgc ttatctatca attagatttt atgctagaag 111420
tgatccatca tttagcgctg cttcacaaac aattggcaat ggacaaggtg ttattactct 111480
atttacagat aaaacagatt ttgctggaac agtatttgga acagactcct atactgtaaa 111540
aacaaataat attgttcaag atatctggag taattactct attaatataa ctataccaac 111600
tggagcagca tttatgaaag tactattcta taacgattca acaactccta ctaattattt 111660
tgactttagg aaacctagtg tagttctata ttctggaatg tttgatttct ggcataaaaa 111720
tgattcagcc aatgcccaaa ttagacaaat tttaggtgac gaatcactag aagaacttgg 111780
tttaattgct ggttttgaat taaaaggttt aagatataag ctagaccaag atattcttct 111840
acctaaccca aatacagaat atactctaag ctggtatgct aataaaatta gtcgatcagg 111900
gaagagcaaa tattatgtaa aagtattaaa tacaaaaact ggagcagaaa tagctgtttc 111960
agaagcctct gccgatacta tcggatacca acgaatgtct gttacttttt cagtaactaa 112020
cacaagtgca gttactatta gaattgggct agaaggagaa ggaagcgcag atgcaacatt 112080
gtccgcagca ggattaatga ttaatattgg tccttatcct ctctcttggc aatcccatca 112140
tgaagaagta tattctacaa atgttcgaat tgatagtagt ggtttgaaag tattcaattc 112200
tgattacgat ggatataatg ttatgactcc tagagagttt gcaggttatt atcgtaatgg 112260
agaagtttat gaaagagtat ttactttaaa taaagataca acgaaagtta aaaaattaga 112320
agcgcaagaa agatttatga tgaaaccagt acaaattgta tcggttgact ctccaactat 112380
tcaaggctgg gcctttgttg gatacaatgg tgaagatact gactaaaaat aaatggtcat 112440
tcctaattat ttgggagtga ccatttctta tttcccaaga gagaagagga aaaggaggaa 112500
atttaataat ggcaacaagt ggagagaaat atactgcttt tgctcgacat cgtttaaatt 112560
gtagatggtc gataaaccga caagatattg ctggtaacta cacaattgtc accggttttt 112620
tatatttaca atctatggac ggctatggag ctatttcagc ttctgccgtg ggtcaagcac 112680
aagttacaat taatggacaa aaacaaactg agaacgcaac ttctcaatta agtgcgcatc 112740
aaaataaatt attattagct aaagattatc gagtaggaca taataatgac ggttcaaaaa 112800
cgactactgt ttctggaagc tattttgtaa atgttacatt cgcaggagtt tattatggaa 112860
cgatatctgt tgggaacttt aatgcaagtt taccaaaaat tcctagacat agttctttga 112920
atgcggtacc aacatttaca gttcctaatg gatgttcttt ttctattagt agacaatcta 112980
attttaatca caacttaact ttttgggttc aaaatagagc aaatcctagc ttatcagatg 113040
atagtcattg gacttattta acgaacgtag ataatgttgc tacaagtggt aaatttaatt 113100
ttacagacgg gcaattagca actattgcac aaagaattaa acaatttgct ggtaatggtg 113160
gaaatatttt ggggaaggtt aaactatgga caaatggtgt gtccggcctt agtcaacaac 113220
gaacagttca gattgctcat ccagcaccag taacacccaa gttagcaagt tttaagttaa 113280
cagcaggcaa ccaacttgct atacaattag ataattttca atcaaataat aaatttaaat 113340
atgatattac atttaagtgt gcaggttgga ccaagtcttg gagtaatgta actaccaata 113400
aaatagattg gactctaact caagacgaag ttaacaatat acttcaaaga tttactggcg 113460
cctcaaaaaa cggttttgct attgaggcaa attcaaaatt agcagggagc caatatagga 113520
atactgttgg ttctagtggt tctgcagaag ttgatacaaa tacagcctct cccctaataa 113580
ccgaaggttt ttctcatgaa gatacaaatc aggtatctat tgctataaca gggaataaaa 113640
aaatactttt agataaaaat tctactttaa gagtaacagt ccctagttca ataataacaa 113700
ctagagatta tggcaagcca gctagtgttg aggcatcatt tgcaggaatt aaaaaaactg 113760
ttaattatgt agaaggaaat atggttttag actttggtat tattacagga acaacaggaa 113820
atctaactgt aacagctatt gatagtcgag gattaaaagg aagtgcttct tacgaagtta 113880
cggtacttcc atataatatg cctgtaatta actttaatgt aagaagaaat aatagttttg 113940
agacagatac tttagtttca ggtacttcta tttggtctcc tgttgatgga aaaaataaaa 114000
ttttatctgt acaataccaa ataagtggtt cagataaggt agatattcct tttacgacag 114060
cagcaaatgt tttaagtatt acagcacaaa cattaccatt agataattct aagtcttgga 114120
cagttacaat attcattaca gataaaaccg gaacatattc tagatcatat aatattacag 114180
aaggtaagcc cttaatgttt atcgatccaa accgtaaatc tgtctctttt ggggattttc 114240
caacaactgg ggaagaaaga ggtttgtctg gtgttctaga aattgaagca gaaaaatatc 114300
atgatactgg taaaacagga attcaaatga ataatagtga tatatcagga ttaaatggtt 114360
tatttttctc taatgataca atgaataatt ctggagaagg tttgcatttt ataaaatctg 114420
gaaaagatat taattctcct agacatgaag attatgatta tatgtacatg agagataatg 114480
gtttttttgt aaatagtgat tcaagaccat tatttaaggt aaatgacaac ggataccaaa 114540
ctacatctag tttatattat tatgaacaaa acattgcaag taatgccaat tttaaatcgg 114600
cttttataaa ttattctcga tggggtcaat tagtagtggc tgctgtaggg tttaatttat 114660
taaaggatga aggttggaaa gtattaacta aaccaccagc aggtttcaca ccatcgaatg 114720
gaggagctac tacattaagc tctcaatcct atcgaggtaa gactgttggt ttatatgtag 114780
gtaatgaagg ttttgtcata gttcctgcta ttggagcagg caatccaaac ggagatacgt 114840
atagagggac attggtatac tttacaaacg ataattatcc tgtatagaaa ggagaaaaaa 114900
taaatgtata cagtatataa aatactatca gaaaaaaatg aaaaaggaaa ctggtatgaa 114960
aaatatgata tacccattgg cattccagtt ccaccagact gtgtgttgac cccaattcca 115020
gaaagtataa aaaatcctaa atatgatttt gcaaaaaatg agtgggtaga agaccaagaa 115080
gctttaatta aaaaattaaa agaagaaaat caatctttaa gagaaaaaat agaactaaac 115140
gaaatggcat tggtcgatgc tattaatatg ttatctaata tgattattga aaaaacttaa 115200
aggaggtgat tattaatgta tccatattta gcaatttttt acgcaagtct tatcatcaaa 115260
gacccagaag gctggaaagg gaaagaaagc caaattccag ctatgattcg ggacgatgtt 115320
atgaagcttg tagatgaaat ggcaaaaaaa gacgtgccag ccgagtaata ttatttggtt 115380
taggaatgtt agtaggtttt ttactagctc ttctaatctt ttaatctcgg caaaaattaa 115440
ggaggaaata aaattatggc aaatattgat atgagtcaaa ttcaagatgt tttcgctgct 115500
ttggtagcat ttggtggtat cttggcacca atcgtatttt atattattca actaatcaaa 115560
ccttttattc ctagcgatta tactaaatta atcgcagtag ttctaggagg aggtatcgga 115620
gcagtactag tggcaattgc tcctgctctt ggaattgtag gacttaacta cattgttggt 115680
ataattggtg gtttaatcgg tggttatatt gcaactaatc aatttgatac tgctgctaaa 115740
aaaggctttg aaaaaggtct agatgaaact aaacaagaaa aataaataaa ataaatcaat 115800
aggctgtcat tgcacagcct atttttttac attaaagaga gtatttataa ggaggtatat 115860
aaatggcttt tacagatgat tttttaaaaa aaataaaagg tggagcttat gctagttgga 115920
aaaactataa ggtcttacct tctgttgttg ccgctcaggc agcattggag tcaaactggg 115980
gtagaagtgc cctagcaaca caagggaaaa atctgtttgg ggtaaaagga agttataaag 116040
gacagtctat tgtttttcct accctagagt ggactggtag cggatatgta actattaatg 116100
atgcctttgc taagtatcct agctgggatg tttctattct ggaacatggt aaattaattg 116160
gagaagccac taattatcgt gctgctattg ggaaaacaga ccctttagcc caaatcacag 116220
caatttggaa tggtggtttt gcaacagatc ctagttatcc aagcaaagtt atgtcagtta 116280
ttaatgctaa taatttaaga gcatgggact tagatgcttt ttctggtgga gatggcggag 116340
gattcagtgg agatatagat gggggaaatg gttataaaaa cttttctgaa aaccttatca 116400
agaaaaatgg tactacaaga ccagggttta aattagaagc catgcaagca attgtattgc 116460
atgatattca aagtggttct aatttaggtg gaataaggaa tactcttaat tctggaaatg 116520
gtggacaaaa aatgggctat cacgttattg tatcagagaa tgatgcccaa ttagtagtgc 116580
cttttacaga aggagtttat catgcagaga gaggcaaaag cttagttgct ggtatgagta 116640
atccaaataa aaaaactatt tctattggag tagtaacaaa acgttcatta tctaattttt 116700
ctactaattt aaatattaaa ttagctttag ttattgcaga aatatgtaga gcatataaaa 116760
tacctgcaac cgctgtattg ccagcttggc aagtagatgg cgtaaacgaa cctgttagct 116820
ggtataataa tcctttctta tatactgctt ttgtagggat ggtaagtgat gccattaaaa 116880
aaggagaaga tgtaattaca aatcctgact atgacagtgg aggaaccagc ggaggaggaa 116940
ctggcgctga tggtttaata ccaaatggag aaggcacaat taagaatatt attaaagaag 117000
ccaatgattt gcttggatca atgacctatt cttggacaag acctgcccaa ataagaaaag 117060
gcggttttgg agactgttct tcattctgtc aatatctata tcaaaaacat gctaaggttg 117120
atataggaag ttatactgat gcccaatggt ttggaaattg gggtaaaaaa gttaatgtta 117180
aagatgctag agcaggggac ttaatattct ttgctggaac ctatgctact aatatgacaa 117240
ccactcatat tggaattgtt gttggaggag gaaaaatgat tgactttggt tctactccag 117300
gtccaaaatt aaataattat aatgatagtt attggggacc aaaaatctat ggtgtgaagc 117360
gaattttttc tgatgcagat tataaccaat cccaatcagc aggagaaaaa ccttcaaaac 117420
ctacaattga tcctaaagga acatatgttg taaatgttaa aaaaccagtt gttgcaacca 117480
acgctgatgt cggtggagta tctcaaagaa gactatcttc caatgaagtt tatagagtac 117540
aagaaattgg taaaactagt ttacaattag cttctaatga attatgggtg cctaagagta 117600
gtggcgcgat aacagtttca cgattatcca ccccatcctc tcctattggg gctatttcaa 117660
ctaaattacc tacaaaagta tattctgctc ctacttatgt agcagaacca gcaatagaga 117720
aaggaacgcc aagaattctt cctgaaaaaa caagtatgaa tatttacgct gtagagaatg 117780
ggtttgctca agtggattta gaaaaaaatc attgggctgt agctaattct acatatgcga 117840
ctttgaatat tgatttatct gaagaatttg tagaagatat taattttgaa cagggcattc 117900
caacttcaac tactgtaaga ggacggtatg aaccagaaga ctttattaca gtagagaata 117960
gtttgccaat taaaaatgga ttagctgtag ttgctcatcc agatttattg gatattggtt 118020
cagtaattaa tatagaaatt ccatcagcaa ctaaatataa tagaaaagca gttgtggtat 118080
caaataaatt aaatgattca gatggaaatg tattagaatt gatatttaca aatcaaggag 118140
atcaatataa ttttggagga agaactggaa ttattacatt attagaagta ttagataatg 118200
atgtagatat tacaaaattt atgaataatc cagaagatta cgaacaaact aaagctattc 118260
ttccaaaaac tccagaagga ggtatgttag gtgagccaaa gtaaatcttt aattttaaga 118320
gacccaaaag gacagaattg gttggtccga gtataccatg aagatggtat ccgtcaattg 118380
tatacaacaa aaactgacga agagggagaa aattcagtaa gaattaaaac ctatcaagga 118440
tattataaga ttaaaataag tactaaagga caactaataa catttccaat tgattcaatt 118500
gggtaatata taaaaagaat tagagggtat gcaataacaa tgtgcttatc ctctttttca 118560
atacttttag agcaaaaaac aaaaggagga aaaggataat ggaaggattt aaaaaacaca 118620
cttttcgtga ccatcaaggg aatattatac ttcctgagac agtctcagaa atggtaagag 118680
aaacaccaga tagacgtttt gtagataatt cagaaaaaca aattttgact agatttggtg 118740
gcaaaatcga tattgttgat atgttaatta ctaatgcaga ggctattcgt gcattagcta 118800
cacaagaggt tgcattaacc caattaattg ataaagtacc aaataatttc gaggacattg 118860
ttttaactac agatgagcta tcacgtttag ttccttatat ttcacaatta attgaaaact 118920
taagttatcc accagttgta acttctacaa cttcaggttt atcttatgct ttacaaattg 118980
atgatacaga tccagataat ttaaaactta aattcgcaca acaatctatt aatacaggtc 119040
aaccactaac ttatgttaag ggagataaat ggaaggttca accaggagta ccagatgtat 119100
tagttgaatt agcaccaact catattgctt ttgataactc cagaaaaact gttttagtct 119160
ttaacgaagg caaaaatttg gtggacgtac cagaagatgt atttacaaat atagttaatg 119220
gtgtccaaga agaaactatt gctgcagaag atgataatat tccacaagca tttgtacgat 119280
ttgcggttcg tcatcaattg caggaattat tcgctacttc taaaagttta gaaaatacta 119340
tttcaaactt tactattgaa gtattatcac aaccaatgga aggtacaaca agtgcattaa 119400
cgcaagctta tatgaacggt aatgtagtac aaccagtgcg agaagcaaat aaaaaagaag 119460
attatactgc taatactttc caaaatatta catggacaaa tagtttagat actaacttta 119520
ttagagaatg gctaaacgac tctggcgaag cagcattggt tacttatgga aaagctaata 119580
attctattag tatcgcaaag ccaacattaa aagtttatat taaaaatcca tatattggaa 119640
aaacattagt tgctcaaaat gatatggatg gcaaatttaa tatcttagat tgggctatta 119700
gtgaagaaga ataaaagaga aaaaggagga aagaactaaa tggctattta ttataatatt 119760
ttatatccac cattagttcc tattacgcat cctgcctttg aattaggaaa accaactgac 119820
acgtttagac ttttttttga accagcagtt ggtaacaaaa tttctgattt taaaggagga 119880
tttattagaa tcagaaatgc tgagacagaa aaaagtgcgc tattaccagt tggagaagga 119940
tacctagatg attttattcc ttttagaaat ccatttgctg aatatattga tttaaaagat 120000
ccttcaaaaa atataattca gccaactgga tataatacta caatgcctta tgtacaaaaa 120060
aatgctaatg gagaatattt cattgatata aagcaagaag cttttactat gtctggcgca 120120
gaaaaagatg ttagatataa aatgcaaatt atgttaacaa cagactggct ttcttctact 120180
aagccaaatg gaagaggaca tattcaaact tactctagtg atgtacaaca gtatgtaaat 120240
attgataaaa ccacatactt tggaggaaat ttaatttcta agggattatc tgagtggtct 120300
actatttctt taatttctcc tgtaagtgaa gcaatttatg aattacaatt tgatggtaac 120360
aatatttttt ctccaatatt tgaatttgtt ggttctaata tacaagaaaa tattagaaat 120420
aatacaatgg ctaattatct taaagcttat agaattgata tttatagagc taacggagac 120480
gaaaaagaac tctttattga ttcaagtgat tggattatcg gtcaagaacc ttcaaatatt 120540
gaaattagat ggcaaaatgt agtagaatta gaagataaga ataagtatat agttgaatta 120600
tcaatacaaa ctgcctggga cctaagaaaa acatttactt atcatgttac aacacaattt 120660
gaaggaagct tatttagagg tacagttagt gttgaaaacg atcatgataa tgctcgttct 120720
aaaatcaaac taaatataaa aacacctcta caatggggac caaaggaaaa ctttgaaatt 120780
tctcttaacg atagagaatt tgctgacgca aatggagaag tatctgtact tgaaggaata 120840
gacttcttta ataaacaagc tgctatagca ggggaaatga tagtttctgg aattaaccca 120900
ataaaaactt gggaagcgaa agaagaccga tggttcttca gactaaaagg accagagatt 120960
tctacaatta acccctatca agaagaatat ctaatgtatg cccatgccgc tcctcttggg 121020
aaagataaag cttctgaagg tccgtacgaa gatgatatta ttattaatcc tgttattgaa 121080
agtccatcag gagatatata tctaacttac ctagacagtt ctaaaactcc tacaacagaa 121140
ggaggaattg ttggaggtat gggaggtatc gttactattc cgagcgaaga tttaccaagt 121200
tcgcatacct tcttctattt agaagatgaa aatcaacaat tatggaaaac aactgtcaca 121260
attaatggag aattcgttac agaaaaatct catgaaaaag atccaacaga atttttaaaa 121320
cctgtttgtt tctttgattc atatcataat attttagtag tgccaagagt agagacagat 121380
ggaactattg ttcttgatac agtttacgaa aattatgtat tgggcgaaaa cgtccgtcca 121440
atgtatctta atgaatttag atttgttaaa cgagtttatg ctcttgagct tggaagaaaa 121500
actctattaa ctacacaaac ttataaggct tacatgaatg attttaataa gaagttaaat 121560
aagtgggtta aaatacaacc aacaagaaaa tattatatgt atttttcttg tattgatgga 121620
cagataagat taatagtacg agatttatcc gctgatgata gccaaaatag cttagataga 121680
tttacattaa cttattctga aggattcatg aacagtgttg gaataagttc tgatatgttc 121740
ttaacaacaa ctgggttagg ttcagatttc ctaccaaaag ttgatttaag tggtaaggaa 121800
gttccttata caattacagc agatgaacga ggagtcttag gaacggatgt tggaaacatc 121860
tctgctgcaa caacacgttc gagagacttg ttaaccagtg acattgaaga attaaagagt 121920
aaaggagaaa tagaataatg gataaagtag acttaaaaat acaagtaccc agacgattag 121980
aaattgatcc tccagctaat gtgggacctt ctaaattccc tagtgttgta gatcaattaa 122040
aagtaattga atattcaagt gttccttctg ggggacaact agaaaaagac ttacatgatt 122100
attatgctat cttagcgaat gtatcaaata atacagcatc agagcaagac tttgtaaaac 122160
ttaaagagtt gatgttgaga gttcgtaatt atgttttgac ggaagatgat tttaatctaa 122220
tggctgatgc tattagaact acacagtctt atttaaaagc atcaattgaa gcggcagatg 122280
gcaactatga actaatttca attgttgctc aacaactagt agaccaaatt aatgaatgga 122340
gtctatggct tcaagatgaa ctagcaaaag tagcagctaa taaaaattgg ggtgcgccag 122400
taatttatag cgaaaatagc ccaggacctt ctgctcttgg atatttgtgg gctcaaccac 122460
aagacgatac ctatattgct ccggcaatta cttttaaccc tgatgaagac ttaaatgatt 122520
atccacaata aggaggtaga tataaatggc agtaccattt gcttcattta aagaatatgg 122580
taatgacgac ttacaactat actatccctt attaatgact tctccagcta ttccacaggc 122640
tggagatagt tatctttctg atatagcttt aagagatatt tcaattaaat ctatatatat 122700
ggaaggtggt catatggagc ctaatttaga ttgggatggt ggtcgttatg attgggcttc 122760
tggagttaca gaaatacaat cagactttgt tgacgcagga ggagaatctc caacaggtaa 122820
ttttaaccta ttaaagaata cagctttatc aacctttcaa agtactcatt ggacctcagt 122880
ttttgaaaaa ccttatgtag agggttctga tgatattgaa caaccttata attggattta 122940
ttctaaatct gaaccttccg accatagtaa aatttgggta gatacaagag aagaaactat 123000
agaacctaaa tattatcaaa atggctggaa aaattattat gattttaaac aaaaagagtt 123060
taaaggtgag gttggattag tagaaaataa aagaaatgga aacgccttta gaatttataa 123120
agctcctaaa attaatgcta acataggaat cgctcaattt gtaccattaa aaatagttct 123180
gtggcaagga gatgctatta cagttggctt taaccttagt gagaaaactg attcaggtgg 123240
agcagtaatt cgtatagaat tctatgataa taatagacaa ttaattcaaa caaaatattc 123300
tcctagattc tttaataaaa ctgaagaaag taaacatttt ggacatcctt ttatttttac 123360
agaccgaaca aaagcagctg cttttattag agtttctatt cttggagtag aagatcgaaa 123420
aagtgaatta caagtaaata gaattaaagc agaaataggt atggaagata caggatggaa 123480
tttgcatgaa gaagaattat tgttaaatct taatgcagga gaaatagacg ttccaatgct 123540
gaatggagag gttgataaat ctaaattaat ttctgaaatt gcaatcttgc gttctgtttt 123600
gggagaagga ttgctgaaat gggaagaagt aactagacta aaatctagtt cagtacaaga 123660
agcaatctta tatgattatt ttatagaaaa tggaaattac tatcggtatg ctttgcaacc 123720
tatattagcc aatggaatga aaggtgctat tacttcattt tatgatactg taactacttt 123780
tgatggtttc tggttgctag gagaaaaaga tgaacagttt tcatttattt acaatggtaa 123840
aattggagaa atctcctatg taaaacctag agatgttatt caaactattg cagggcaata 123900
tccatatttt gtaacctctt ctgaattaga ttatagaaca tatcaatttt ctggtacgtt 123960
aacctatcac caagatgtcc acaaattact tacttctgat agttattctg tagcaatatc 124020
tccagatcca actattccta ttagttatgt agaactaaaa tatggagatg aaatgttgct 124080
taatatgaag aacgatttag aagaagtaca agatggcatg gtaatgcaaa gaatttggag 124140
aaacaaaatt ctagcatggt taaatgatgg aaaacctaaa attcttaaat cagaagctca 124200
aggaaatatg ttagtaatgt tgacaaatat taaggttact ccaaatgaac caacgtttgg 124260
tttaatttct gattttgaat gtactgttac tgaaattgga aaacttgatg aaaaagcatt 124320
acaaaaatat aaacttcgta aatcttctat tatgaaggat gagcttgtaa aagaagctat 124380
gaaaaatact tcgttctaat aaataaaatt aagctgggga acttgtgata gtacccagtt 124440
taattttttt atataaaaca taccaagagc aaaggagaga aaataatgaa tgaaaatatt 124500
aatgttaagc agtatcctac ttcttttcta gaagagcttt tcgagcataa tattcgagta 124560
gtgcatacta agatacagtt acttaattgg gacgaacaag ttttaaaaga aatacaaggt 124620
attgtaaaaa gcggaagtta taatgctgac ggaacaagtc gagtaagacg aaatttatct 124680
ttaaccttta gtgtaaaaga tagagacgat gaattagtct ataaatatct aactccagat 124740
aaaaaaataa aattatatat aggattggaa aaccaaactt ctcgttatca agaagatgaa 124800
attatatggt ttaatatggg gatttttatt ttaaccgaac catcttattc tcattctgtt 124860
gatacagcga ccatatcaat taacgcgcaa gataaaatga ctatgctaaa tggtacatta 124920
gggggtcgcc ttccagcccc agtaagtttt gtagaaaaaa ggaatggtaa gaattattcc 124980
ttctcttgga gagatatttt cttaagcgca gcagtaaatt ttgggaatga gaatccagca 125040
aaggttatta ttgattctgt cccagattat ataaatgaat atacgcaagt aaaaaatgtg 125100
gctggactaa aagataaatt tattcatatt aacgctcctg gagatgtaga aggagaaaga 125160
attattacta gggcgtggag tccaactgtt ccagaaacag aaattaattt ttcaaaggga 125220
gatagagtct acaaattacg cagatttggt ccacctgacc cttcagcagg aacagtaagt 125280
acccaagaat cttatcaaaa gaatgtaaat gaaccattaa cctctatttt tgaagatatt 125340
gtagaagcta tgagcaatac tcatgaattt ttctatactc gtgatgggga tttaatgttt 125400
caacctatca agaattatgt taatgaagta tttgaccctg aaaaagatac agatttagga 125460
tattttgctt atgaattaga catggatgat tttatcccta attatttagg tctccctttt 125520
acctataatt ttgccgataa aaagactatt attagatata acaacaatcc tagttataca 125580
aatatcaaaa atgattttat agcaactaga gaaacaggag aaattttaga aatagcaata 125640
gaccataaac caacaattag agagattaaa gaatggtttg ttgggattgc agaagatttt 125700
aatatggatt ctccagaaat ggatttttta gcaaaagatg gaagaagaag ggagccatat 125760
aaccctcaaa ctaatacagt tccttttgaa tttaaagaag ccacagcagg gaaaccaaca 125820
caatatattg aagttccttt agataaaatc ccatggcaaa ttggtttagg acttaaaaat 125880
tattttatta gaaatatcta tggcgcttct actgcaagag ttctgcctag atggggtaag 125940
gaatgcgaat caatgatttt taaatggatt gcatctgaag ataaaaaaac tttgttgcca 126000
aatactggaa tttttaatcc atcctttatt tctgtcggaa ctccatggtt agcaggttat 126060
cctatggctg caagcgcaaa cacagaaaat gatgttgagt ctttagataa acagaatcct 126120
atttttactg acaaaggtga ttcggcttat tggacttact ttcttgatat tataccaaca 126180
gaatctaaat tgggtaaata ttctattgag ttaattggta aacgttctat tggtgtttct 126240
aataaacagg caactaccat ttttagaaca aaccctaaag aattaattgt tattacagaa 126300
acagaattac aagatttagg cggagatatg atattagata atttaaaagc acaaggagaa 126360
gcttatgcag taattagaga tatacaagat caattcttta tgccaacagc aataacaaaa 126420
aataaaaatg ttatgcctta tagtgctata gttggagacc cagggcggtt tgaacaatta 126480
agatatatgt ttgcagaagg caatggaaca gttcatgaat atttagctgg tggtaaacat 126540
actggtacta ttggggtaaa taagaatatg caagatcaag ataagcctgg atatgttaca 126600
atttctgctg gagtatacac caatccagtt acaaaaagac agtttactca aacagatttt 126660
gcaaccataa atactccttt tggtagtgaa aaagatttaa cggaatatgg ttttattgct 126720
tatctattaa acaaaaacag ccgctgtcct gatagtggaa atcataatta ttttgctgta 126780
gttaaaaata taggtactca atggtactat gctaaacaaa ataatggaaa acctgcatgg 126840
actaaattta attgggataa aaccaacgac tttttggtag cagtattaag taaaactgtt 126900
tataaaggaa gtgcagattt tcctgattgg tcaagtggta gaattgatga ttttcaagag 126960
ttatttaata ttagagattc taaaatggat aatttattta ctattgatgg agcggttgat 127020
ttattttctt ctgttaggaa tttaatctat caacatacta atacttcaga tgtagtaaca 127080
atagatgtat taccagttta tcatttagaa ccaaatacat taatttatgc agaagatgaa 127140
atttcaaata tatcaggaat gtttatgata acaggatatt ctatacaatt aaacacagaa 127200
ggaagtccaa caatgaatat ttctgcaata caaacaaatc cagctatata aaaaaagaga 127260
cctatgtggt ctctttttta gttccaatta atttcttggt gtgaagcata atagccaatc 127320
ataattgcat ctgcctcgtc ttgtgttgca gtaatatcaa atagttctaa tactttagcc 127380
tgagcatttc ttttttgttc tattctattt ttacctttaa tcttagcaaa tcctttccat 127440
tgagaagcgt agataaaatc aaaatgaatt tctggatgag cctctaaaac cccaacagca 127500
agagcgcctt gtagttgagc taattgttta aaagtagttt tattttgctg catttgaata 127560
tcttcaaaca ttatttttat ttcttcttta ggatattttt ctttagtata ttcaattaac 127620
gctaatacat ttgctttctg ttttgaatat cttgagaaat catctccttc agcagaaaat 127680
tttccatagg caattaattc ttgattctta taaacagaat aacctgttac aaccgttgct 127740
tggtctaaac ctataaaaat catattaaaa cacctcccta ctaataaata gcaaagaggt 127800
gagacatgtt gtcttttttt gtcctatata agagaagaat atctttctta attattttac 127860
tcctgtactt ccgtgcccgc caagacgttc tccttgagca ttatcgtcat ctaccaacaa 127920
gaattttgaa aatactcctt gtccaatacg ttctcctttt ttaatataga tagtttcagg 127980
accaaaattt agaaattgga acataatatg accatcatta tcaggattgc tatagtagtc 128040
accatcaata actcccacac catttgttaa aactaagaaa cgttttaatg gatttgaaga 128100
acgattaaat aaagctaaat attcatctgg ctccatataa gcttttactc ctgttggaac 128160
taaaactggt ttaaattgct tacttaaagt tttaatttct gaaatagctt catcacttaa 128220
taactctttt agaatttcat tgttttgatt ttctaaattt agagtattaa ataattctgt 128280
ataagaggca gggtctgaag ctaattcttc taaatccata cccttatctt ttaaaagctg 128340
agtaatcttg gtaaggaaat ctgtaacttt agaaaatagt tctaaagatt caacttctgt 128400
taaatgttcc ataacttgac taattgaatc tggatcttgt aaatcaatat taaacccaaa 128460
tagatcttta gaaaggatac ttgaaattga tttcttatga atttctttaa tatcccaaac 128520
tgaaggaatt gcaatatcat ctgatgcttc aaaatcatat cctgctgcac gagcagttgc 128580
tcgaacaggc aggttaatat ttttatcttc aaaacctttt gctacttcaa atccacgtac 128640
ttttgtcata attatttagt ctccttttta tctttttgcg taaaatcttt aactgactca 128700
acaatccaat cgttgctaac taacttaaaa taagtaagtc caatatagag tccaagctct 128760
ccatgagaag tatcatcaat atctcgtaca tccatcatat cgatcatatc agcttctaca 128820
atatcatttt catttttatc tttaatattt tcttttggtt ggcaaaaact agaatctttt 128880
aaataaccta agatatgttg agccacttct ttatctgtag actcagttcg atcaaaaact 128940
acattatagt taatatctcg tgaattaatc caaaaatatt ttccaaaaga ttttctaaca 129000
aaagttagaa cggcttgata aatatcttct tctgataatt tcggtgcgtc ctttaaagct 129060
tgtgtaatta aatccgattt tttcattgtt tgtccattat ttttcttttt catattaatt 129120
attctccttt aatttttcca taattttatc ttgtaaagca cttaatgcca tccatacaaa 129180
gggtgtatct gaaaaatagt aagtatctgg ctttctatca atttcagcat aatctttttt 129240
atctgcttca attcgtcgtt taatttcatt tacgtcagga ttcttttgtc tgccctttgc 129300
tcgttccatt cgaatctttt catccgctac aatttctatt aacataacat ttgtatcctc 129360
tgatttacct acccaatcag ctacttcaaa tgcagtctct ttttcacaag tcattaaata 129420
gatagattct ttatctcgag cctgagcagt aataccaaag taaacaccat aattccaatt 129480
attaaatacc ttaggaaata gaatttcttt tttttctact cctctttgaa aaacttcatc 129540
agttaaaaat tgataataag attcttcttt gtcggaacgc ttgggtcttg ttgttggtcg 129600
tttggctaga taagcatcta caccaagaga gccaagtaat ttccttgcaa tataatcttt 129660
accagctcct gtttgtccat ataagattac taacatttta tctctccttg ttttaacttt 129720
ataattaatt ataacatatt atatattatt tgtcaatctt tcgccaagat cccagtttta 129780
agtactgaga cctttaacgt aagataatta acctcgtcgg attaggctgc tcgttctgtt 129840
ttcaaaacaa tacttccatc atcacgagtt tcagtaatta atccaatctt tggagtcgct 129900
gtatcattat atgctctagg aataaattga tcgtcacgtc taaaaccagt aataaataat 129960
ttgtttcctc tttcaaagaa agatttttct acaacagttt tcttccctgt tgatgttctt 130020
tctgagattt gtttatccca gtaagaaaaa tctcctttgt acattttaac taaaacaaca 130080
gttccttctg gagttaaaac atcgatactt gctttaacct tatttttacc aataatagtt 130140
ccaacaattc tatttaattt tagcttagaa aaacttgcgt aaggattgat tttttgtgcc 130200
tctcttggaa gaagctcaaa attatcaatt ccatatctat ctacatccac acaatttaat 130260
tcatgttctg tataatagaa gttcatagat tccatttccc atcttgcata tgaatcgtga 130320
ccaccatatg aatcaaataa ttctaacatt tcatcaaaaa atatttcttc taataaagac 130380
tctttattct ctctcaacca atttctaaca gtatccattt ttttgtcata aaacttactc 130440
catctatctc gactcatcac agtccaataa cgatcctcat cactaaacgt ttcaataaat 130500
tcatctaaac caatcgaaga taaaaagttt tgcgcccggt catcaagtct aacaatttgt 130560
ccgctcttgg ttagaacttc atttatataa cggttaaact cataaattcg tttttcttct 130620
tgtaatgatt cagggaatct attaattttc ataaccaatg ggacttgtgt cattgtgaga 130680
ttttttctaa gccctgtcat cattttagca tattttgcta aagtaatctt tctatcagga 130740
ctatctattt ctctaaaagc tcctgcctta attaatgtta gcatttgcat tttatttggg 130800
tttgtttttc tgacaaaatc tgctaaagaa ttaaatggtc ttccctcgaa aattttctga 130860
ataaattcat aaccaatccc agttaatggt cttaaaccgt aagaaataaa attaccttct 130920
acattaggag aaaagtttga ttctgattta tttatatcta ccatttctac tttaatccca 130980
tgtttaatag tatttcctag tgctactgcc attttagaat aatctgttga agttcctgtt 131040
tcatctcctg agttgacaat taaacaacca cagttccaat aaatagatgg ataatgatta 131100
aataagttta attcttgtag tgcaataatt gtatatccaa tcgtatgcaa aattgagaaa 131160
gaatcgtgta tatcctatat tactataggc actgactata tcttaactca cgttatgtga 131220
gcaatggcta tttcggcatt taaatgactt cgtttcctaa aatcatgcta cgtatcaata 131280
gtagccctac ttccctgctc ttcacttagg gaatagtcga tacaggtttt ttagtatatg 131340
ggcgaatagg ataagtatca ctcaatcctt ttcttagttt tccataatta atttttttaa 131400
cggtagaaac acttatacca agtctctcag ctattttcgc aaaagataag tttgtttctt 131460
ttaataaaac aattaattct tcgtagtcag aagaagttct ataattttta attaaaggat 131520
aactccaatc tttattaaaa tatcttaatc ctatattgat attagaaatt aaagtttttg 131580
aaatagagta ttctttggaa atttctgtat aactaactcc attttctaat cgctctttaa 131640
tttcttctac ctgagaaata ctaagagaac cttctataat actttcgttt cctccacgat 131700
gaatattgta tccattctta ggagaagtag tattatattt attaatatag tatatttctc 131760
tttcatcaag ataatcagtt tcctccaaaa taacatgaac aaagttttca tatccatatt 131820
ttctaaaagc tctatacaat ggataattat aacatttagt tttttcatta aaagccattg 131880
agaaatgttc tctctttctt cgctctatat tatttgtttg accaatatat ctttttccgt 131940
taaacatgtt tatatacgca tatatataac ccatttttat atcctcctat tgaggatacc 132000
atactaaaac ttcccacggg attgtcctca gcattacctg gtaggatttc cccgttagca 132060
cagtatactc attttgttaa aataagtaaa actgtacccc acttgattac agtggaaaaa 132120
ccatttaagg gcgttcttat tcaccccatt tgaacactaa ctgctgaatc ccaaatataa 132180
tgaattgttt catttgaaca tactgcttgt tcaaaaattt tagctctaag ttctggaatt 132240
ttatccatta gcttcttacc aatgatttta cgtgctgcat tagcttctgt ttctgtaaaa 132300
ttacaaatgt ttttatccat taaaatcaac attaattctt cctgtgtatt tggaacccca 132360
taagaagata agaaatgttt ctctaggata ggaatttcat ctgctggaat attatatttt 132420
tctaattctt cataccaaag ttggatattc tctttaaatc ttgcatattt ttctagtggc 132480
atttcaccat tttcagttgc cataagcctc atcaaagaat tcaatgctgc tgcatctttt 132540
acatcttctg gtttaccctt ccttacagct tcttttccta caggtgtatc aagctgaaaa 132600
atatccaaaa ctttgttatc ccatgttggt tcccataatt ctttgctata atctaataca 132660
tcgggatgca atgtattaaa atatgtttct tttaaagaac ctttccattc cattctattg 132720
tctttaatca ataaatccat tgtttgacga attttatcta aagcttcgat agacaacata 132780
tccattttta atgctcccat atcatcgcta tcatgataat cccattgagt tacttctaag 132840
tcgttaggag ttttcatcat agcattaata tctgtataag gatgattaaa aatataaact 132900
cctgaagcat gagaacctct actttttacc attccttcaa tagctaaagc tgtttctaaa 132960
taattttcgt atttattaat ttcattaata aattcagaaa ctggtttacg acctttttct 133020
ggattcccat aaaccatatc ttttaaattc caatcaaagc cacgttcatt tggaatcaaa 133080
ccacttaaat aacttgaaac atcatcactt ataccaagtc ctcgtgcagc agtagctaat 133140
gctgattttg ctttttcagt tccaaaggtt gcgatattta aaactctatc atgaccaaaa 133200
aagtttttta acgccaataa aatttgttct cgtttagaac cttgtgaatc tatatcaaca 133260
tccatgttct ccctagtttt cactagggca cagactatat cttccttacg tatatacgta 133320
aagtgaatgc acttcggaat ggtgcttatc tccatcccta cgagtataaa actctagtcg 133380
ttacacgttc tttatttcaa agtctccagt ttttctatat ttttctaagc ttgtaaaact 133440
tgctcctaat tcttgagctt ttctacatgc ttcttttacc gaaccatata ttcctaaaga 133500
cacactattt tgaaaaagct caacttttcg aaaatttcgt gtggatccaa tcccactagt 133560
ctcataagac ttatttatat tttcttgtgg agagacccac tctaaatttt caacacaatt 133620
gtttaaacaa tttccatcta tatggttaac ttgaggaaga ttattagggt ttggaattaa 133680
agtttcagct attaaacgat gtaccaaata ttttttaagt ttcccatttc gagacaactg 133740
gacttgtttg taaggacttg ttgttccaga ccaagttgct aaaatttttg gttttgtcat 133800
tttaaagctc caaacatttc cctctctatc taccttataa tctccattat atccgtcaat 133860
atcatatagc aatttatcat ctccaattaa ttatttggag aactttgaaa taaagcttcg 133920
cacggtatta tccagctatc ctattctcta ggaccttaga ctctcttaga aagctgcttc 133980
gtctttgtta tatctccacc atctcgttgt aacgcttgtg tggaagtctt attcaacttt 134040
taccgttagc acgatttatt taatcgtaca ccctttagca aggttcacat tcaatgccca 134100
ataagtttag gcaattctgg acgactttca gctagatgtc tccaactcat atctcctaca 134160
tatgggatag gatctacttg tgtaacgtcc aacaaccagt ttgacataaa tcccatagct 134220
gaaccacgag agactccaac caatgaatct ccttcatccc aaattaattc aataattttt 134280
tgagctgtat tataataaga tgtcataggt tgttttaaac gttcagaaat ttttactaat 134340
gtagtagctt caatttccaa ttgttctaag tatctttcat ttaatacatt cctaatttct 134400
aattggttta gacaagttct gctccaatat aaatcttggt cttcatcaga atttaacaac 134460
attgttaaat atttatattt gcttaaatca atatcattat atgttttact taattctggt 134520
acatcaacag gaacatatgg aatttcttgt tccttaaaca aagaataatg tttgattcca 134580
cttctaattt tttctaagtt atctaacatt tcctgaaatt cttcttctga aaaatctaat 134640
aaaaaatatt ccttaacttg ctcaggtggc atcatataag cagtataata gaaatcgtca 134700
acttctcgtt ctgcttgctt actattcaaa taagctttat gaatctctct gtctgcttca 134760
gtaagataat gactatctgt actaaataca actggaacat tcattgcttt cccaagtttc 134820
caaactcttc tatttacata tctttgttct tctgaagtgt ttggagcaat ttctaaataa 134880
aaatcttctt cgccaaaaac ttcttgattc cacaaaacaa aatcaacaat tttttgtttt 134940
tcttctaaga ttttttcttg attaattttt tctccaaatg ggacttcttc tgccgcttta 135000
attttcaaaa aagcttgagc ttcaaaactt ccaagacaag ctgtagaaga tacgatatgt 135060
ccttttccat tttcttgttc cataatttct tttacttgtt cacgagtaat cggagttcgt 135120
tgtaaacctc tatcccaata actattttcc caagccttag aagacaacat tcttaaaatt 135180
ttgtgtcctt ttttatcttt tgcaattaat aaatgatgat aatatttttg tcccatttct 135240
aagtcttcga ctaaataaat ttcatctcca aaaccaattg taaaagattc atggtctata 135300
cgaccttctt tttctaattt atctctataa tgcattaatt gagcgtgacc agataatcct 135360
tcgtgatctg ttaaaacata accacttaaa cctaaatcta aagcataatc aactgattgt 135420
ttaatatcat taattgaatc agcgaatcct aacaatgcat tactaaaact actatgatta 135480
tgaattgaat agtatcccaa taaatataac tcctttcata attccttata tattaattat 135540
atcatttaaa atataaaaag tcaagtaaaa taattacttg accaattcat cataattaaa 135600
ataacatttt ctacatacag gaatatattc gttatctcca attaaaattt gttcacctct 135660
ataaatagct tctccattaa ttgtacgtaa attcatagtt gcttttttat cgcataatgt 135720
gcatacagtt tttagttctt ctattttatc tgcaaattct aacaatgctt gagaaccttc 135780
aaataaatta ttttgaaaat cattttttaa cccccaacag aggacaggaa taccgccctc 135840
atctactact ccggctaaag taattacctg ctctcttgac aaaaactggg attcatctac 135900
taagatagca tggactttct cttttttagc cttttctaaa atttcttctc tgctatcatt 135960
tagatactct gcctcaatat taaaaccagt tctagaaaca atctttttaa aaccgcttct 136020
agtgtctaaa tcagaagtat aaattaatac atttttgcct tgctgagcat aattataagc 136080
agttgtaatt aaagataaac ttttccctga gttcataact ccatatttaa aatataattt 136140
tgccatattt atttctccca aattccacta tttttatcat aagctaatac taatttttct 136200
gaagccctag taaccattgt gtataaccat tttctatgat tttttccatt taatcgttct 136260
tcgattccta aaaccttaga atattcacta ccttgagatt tatgtgtagt aatacaatat 136320
ccataatcaa tataattaat tctagcatca ccttttgcaa actgatttac aatataagat 136380
ttttggtttt ctttaataaa agggagcata tcatacttga tagaaaactc tccaccacca 136440
aattctggaa caaaacgaac tcgagcgatc tcaatatctt ttcccattgc atttcccatt 136500
aatttttcac ttttaaatac accactagaa aaattaactt cacctaacat accattaata 136560
agagggaatc cttcttcgtt taaaatatcc caattattat tagttacaat gattttatct 136620
ccttcttgag gagtaggtga aacaaaaccc ttagctaaac ggatttcatc attgtaaagt 136680
tttctggtcg cgtttcttcc acacaaaact tggtctgccc ataaaagcat acctacagaa 136740
atctcttctt ttggaaccat cttaacaaaa tcatcagaaa aaggttttat aatttcccct 136800
tctcgaatca ttttagataa ttgaataata ctattccctt cctcttggcg catgatttca 136860
tctaagaaaa tgtgaggatt ctttaacata ccattatctg ctcctacagg aggtagctgc 136920
cctgggtctc caagcattat aatgtgaata cctaaatctg ctatatcttt caacaggtct 136980
tctggaacca ttgaaatctc atctattaga attaatttaa ttccttgata gttttcaata 137040
ggaagctttt gatgaataaa attattatta attttgatag acttgtatcg caatttgtgt 137100
aaagtttgtg ctgctgggaa tcctgtttgt tgaagacgat aagctgcctt acctgtaaaa 137160
gctccaacca tatattgtaa tggtgatagc tctagtgcat taataatttt ttttgctaaa 137220
aaagttttac ctgttccagc aaaaccagcg attgtagtat aacgctctcc atttttatat 137280
cgttctacag caatttctaa accttgtttt tgtttacttg ttaatgacat ttaatcattc 137340
cttttttatt cattatattt atattatacc attataaaaa taaaaagtca agttatttac 137400
ttgacttttt atttcgttta gttttaattt gttcccaagc aattaaagca tttttcattt 137460
gacctgggta gcgagttaaa tattctgaaa caaattcttt tttggttatt ttgcgtttca 137520
tatctatcac tccttaaatt tatatgtaag ggggggtggt tttaggaaaa gaaaaatagg 137580
tagaaggtaa atatggttca attcaaaaaa tagcatgaac catatttttc tcctagatta 137640
gcgtccgtag acgataaaat cctttaatat tagaaaatgt atttttgcgc tgatttcaat 137700
tctaaatctg caacaaacat ttgtaggaac gtacgacctc taaaagtact cattttaata 137760
gttccaacta catcaatttt tgattgctgg tttttcataa gtttttgagc tgtttcagtg 137820
ctaacaccct taaacttaat aaactctagt cccccagcag aaaatgttat cttgtgatta 137880
tcaaattctc cacccacaac tatatcatct tttttaacag gaacatctct taaaacaaag 137940
gtaggttctt ccaaaccttt tccccaaaac gtagcataac gagtaatttc tgttagattt 138000
tctttagaca tttgctgcca agaaatatca aaatctacag aatatattgg ttcaaagaca 138060
atttctgata attgtttatt aaaatattct acaatttcat cctttttgtc agcagcaaaa 138120
gcaaatccat gagctccctc atgaccttct gcaaattcaa ataatccact ttcttgctca 138180
aatcgtttta attctggtaa atcagattta tcatctccac gagctgaccc accaaagaaa 138240
gtttttccat ctttttcaaa atacgttcct actaaagttg gcttcttata ttttgaaaca 138300
aattgattag caattaatcc tgtaaaggtt tttggaaatt cattttttgt atctaaaatt 138360
agaatctggt tgtcagttaa tttattttct tcaatttgag tttctaatga attaaaggca 138420
ttatctctca atctatcctg tcgagcttta atattattca ttttccgaac aactgcttca 138480
tggaatactt ctgtatctcc ctctttagct ccacgtttag ttgagggtac atcataaggt 138540
ttgtcactaa ccatggcttt tgtaacttct tttttctcat ccattgttcc tactcgtgtt 138600
actgcattaa tcattgggac aatagaaaaa gataaaccga ttggtgttac ttgtcctcca 138660
agattaaatg acttagcctt gtataatgct tttaaaaaag tattgtgaat atttctcatt 138720
ccttgctgaa caatataaat tgtttctaaa gtattaattt caatcatatc tcctacaatc 138780
ccaatagcag caagatcata gtatttttct gagtggtcga agccatacat tttatcatac 138840
aacgcagcaa attttaaaca aactcctgca cctgacaatt tcttattagg gtaatcatct 138900
aaagaaatat ttaccattgt agcatattct gaaaatttag gtgcatcgtg gtgatccaaa 138960
attacaatag gtatatttaa cttttctaaa atatacttat gaacatcata ttcatttgaa 139020
gaacagtcag gagctatgat taaatctact tcatgttccc ccataatatc ttctactgtt 139080
tttacaggaa ttccatgttc tttgttctct tggaaaataa ttattattct atttgttatt 139140
tcttctttat aacaatcttt taaataatta tagataatag ctgtagatgt ataaccatct 139200
gcatcagggt cttgaattaa taatatttta tcttttgaat ttacgatttt gtcgtgaata 139260
atttcagcaa cctctttcaa attttttatt aaaagaggat cgtgcaacgc tgaatcattt 139320
aatctaaaaa ttttatctgg gtttattcct ctatttatga aaatgttaat aatattgtca 139380
tcattttttc caattagttg cgttctcaat atatatcata ctcctcttcg tctgttccta 139440
tggaatccca tagctctaat ttttctacaa aattttcatc tatctctttg tatgtttttc 139500
gttctccata taattctgca aaaacttcaa aaccacaatc tactggagaa tctttatatc 139560
ctgaaatcat attagtatct aaaataaaac ttattttaat accatcttcg ttagttccaa 139620
accgttcttg tattgtttta aaaattccta ttaagttatc atattctcta tcatacttca 139680
tagattgaaa ttgtctatca aaagcgaaaa taatttcttc tacacctaat ttttttaatg 139740
cttcatattg gtgtcgtgaa aagtgcatac caaatgctgc tacaccaata tttttctttg 139800
gggataataa atcatccatt ttcatgaccg atttctccgt attattctac tatttctagt 139860
agtactgact atctcttgtt caaacctaag tttgaatcac catttcgaac tacgtatcaa 139920
tagtagccct actcccctca aggggatagt cgatacaggt tattaatgtt ttttcttggg 139980
tcttatagga aagtttgaat agctactttt tctaactccg ctgtttattt tacttacagt 140040
tgtttgactt atattatatt ccaatgctat gtcgtcaaaa gattttattc catcttttat 140100
ttcatcagca attttatcaa cttgttcttg agtaagtttt cttcctcttg tcccaatttg 140160
atttttccta attggatatt caatatctga aaactttctt cgtttaccat tatttatatt 140220
atctatatga gcaaacgata atccagtttt ttctgatata tccttatatg ataagtcagt 140280
ttttagaagt ttaataacct ctaaaataat ttcatctttg taagttattg tcggaggaat 140340
acttcctcca ggagtttgat tgtaaccatt tctaaaggta tcatatttag aaatataaaa 140400
catttctttg tcgtttaata gacaattatc aatattttcc tctagtataa ctaaagaata 140460
atatttttct ccatgttttc taatgcctct gctaagagga tagttgtatt ctagaacctt 140520
ttcgttataa gggtcgtgtt taaaatgttt gttatgtctt tgctccaaat taacagtttg 140580
accgatatat aaaatctttc cttttggatt tgcatatcca tatataattc ccatatttca 140640
ttcctcattt ctctttcttt aaagaaatga ataatcagga atgaaatcta cattaatctt 140700
cccacgggat taccatatca tttctgactt aggcttcccc gttagctagc ttatgctaac 140760
cccactgatt agtggaaaga tgaactaggg cgatgttgtt caccctcaaa aacaatagct 140820
tttctttctc ttctaatatt gttagcatta aaaaataaac cgaataaata aaatgatagt 140880
ggtgaagaat acagtatccc ttcacgttca acgggtctat attttccata ccgttctatc 140940
atttcgctat tagctattct ttgtcgtata cctaatagat ttccttcttc gtctaaatga 141000
ggaaacatta aaccagttgt tgcataatta tatctgatat tatatttatg ttgagtttct 141060
gctgatatac cttctcgttc ccaatcattt acaataattc taggataacg taaataaggt 141120
tctttatcat aaaacataaa acttggttct tgatattcaa tatctaaatc atcattatgc 141180
aacatatcat tatcgcctaa agtcataaac tcttgtgatt gaatataaat atcaatagcc 141240
tcttctagta aaagttcttc atgatattca ttcatataca ttttagataa taattcaaaa 141300
atatcaaatc taccacaacc agtgtaacaa ttaaataatt ttgtattatc ataataataa 141360
agtttatgac taccctcacc tttatgatta tgacagacag tttcaaagac taattggtgt 141420
tcatcaaccc aattaccttg aataccttgt cctaccaaaa aatcatatac ttgttgaata 141480
gacattccag cttttatagc attcttatca cgtccatatt ctgccatata cctacaacct 141540
acttttttaa ttatttttta tacatttata ttatatcata ataaaaataa aaagtcaagc 141600
aattagcttg actttaaaaa gcactttttc gatcatctac agtttgatta cgacgcttaa 141660
catttttttc tgctgctttt tgaaccttaa tagaagtagc atcaattcca atagggatat 141720
tattactatc tgtaataaac aaacccttac atctacaagt tcccaaatct acgtcgcacc 141780
acaatttaac accagcatat ttacctcgtc gtactttgta aaagctaata atatagtttg 141840
gacgaaaata tccttgactt acaaatgttt ctacagcttg ttcatcaata ggtctaattt 141900
taactgcaat cattcccacg tcaatacgat ccgcaatagc tttagatcca cgaagcaaat 141960
tttgattaag ttctccctca agataatctc cattca 141996
Claims (9)
- 장알균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EF1.
- 제1항에 있어서, 상기 박테리오파지는 수탁번호 KFCC11692P인, 박테리오파지 EF1.
- 제1항에 있어서, 상기 장알균은 엔테로코커스 패칼리스(Enterococcus faecalis)인, 박테리오파지 EF1.
- 제1항의 박테리오파지 EF1을 포함하는, 항생용 조성물.
- 제1항의 박테리오파지 EF1을 포함하는, 사료 첨가용 조성물.
- 제5항의 사료 첨가용 조성물을 포함하는, 사료.
- 제1항의 박테리오파지 EF1을 포함하는, 소독제.
- 제1항의 박테리오파지 EF1을 포함하는, 세척제.
- 제1항의 박테리오파지 EF1을 인간을 제외한 개체에 투여하는 단계를 포함하는, 장알균에 의한 감염성 질병의 예방 또는 치료 방법.
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WO2022264035A1 (en) * | 2021-06-15 | 2022-12-22 | Ferring B.V. | Bacteriophages against vancomycin-resistant enterococci |
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