KR20180068294A - 신규한 병원성 대장균 특이 박테리오파지 ec10 및 이를 포함하는 항균 조성물 - Google Patents
신규한 병원성 대장균 특이 박테리오파지 ec10 및 이를 포함하는 항균 조성물 Download PDFInfo
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Abstract
본 발명은 병원성 대장균에 특이적인 사멸능을 갖는 신규 박테리오파지 EC10, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 EC10을 이용한 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 병원성 대장균에 대한 특이성이 매우 높고, 상기 박테리오파지 EC10은 병원성 대장균에 감염하여 병원성 대장균 내에서 100 배 이상 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 EC10은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EC10은 병원성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
Description
본 발명은 병원성 대장균에 특이적인 사멸능을 갖는 신규 박테리오파지 EC10, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
일반적으로 대장균(Escherichia coli , E. coli)은 장내세균과(Enterobacteriaceae)의 Escherichia 속에 속하는 그람음성의 단간균으로 포유동물을 비롯한 다양한 동물의 장관 내에 존재하는 정상세균 총 중의 하나이다. 대장균은 일반적으로 대장에 정상적으로 존재하는 비병원성 대장균과 특정 병원성 인자(부착인자 및 내열성 독소 등)를 획득하여 병증을 유발하는 병원성 대장균으로 구분할 수 있다. 대장균은 온혈 동물의 장내에 많은 부분을 차지하고 있는 미생물이나 대부분 비병원성 세균으로 기회감염을 유발할 수 있다. 비병원성 대장균 외의 대장균은 사람에 있어서는 설사증, 요로감염증, 패혈증 및 뇌막염 등의 질환을 유발할 수 있는 병원성 미생물이다. 최근에는 다양한 병원성 대장균이 진단, 검출되고 있는데, 이는 장독소성 대장균 (Enterotoxigenic E. coli, ETEC), 장병원성 대장균 (Enteropathogenic E. coli, EPEC), 장출혈성 대장균 (Enterohemorrhagic E. coli, EHEC), 시가독소 생산 대장균 (Shigatoxin producing E. coli, STEC) 그리고 장응집성 대장균 (Enteroaggregative E. coli, EAEC) 등으로 분류될 수 있다.
한편 병원성 대장균은 닭, 돼지, 소, 오리 등 많은 동물에도 감염하여 질병을 유발 하는데, 특히 돼지에 있어 병원성 대장균에 의한 질병은 돼지의 일령에 상관없이 다양하게 감염되고 질병을 일으키는 것으로 알려져 있다. 병원성 대장균에 의한 돼지 농장에서의 질병은 흔히 설사를 일으킨다고 알려져 있으나 최근 수년간 부종병의 보고가 늘어나고 있는 실정이다. 이러한 부종병은 치료나 예방 또한 쉽지 않기 때문에 농장에서 대량 폐사의 원인이 되고 있다. 부종병은 병원성 대장균 중 F18 섬모와 시가독소 2e(Stx2e, 또는 베로톡신 2e (VT2e))를 생산하는 출혈성 대장균에 의해 발생한다. 최근 연구에서 부종병 대장균 변종이 장간막의 임파절을 감염시키고 Stx2e 독소를 생산하는 것으로 밝혀졌다. Stx2e 독소는 돼지의 적혈구에 쉽게 결합해 체내의 여러 장소로 독소를 운반한다. 독소에 취약한 지점은 위의 점막하조직, 장간막, 앞머리와 눈꺼풀의 피하조직, 후두, 그리고 뇌로 부종이 흔히 발생하는 기관이다. 또한 혈관내피의 손상으로 인해 부종, 출혈, 혈관 내 응고, 그리고 미세혈전을 일으키기도 한다. 임상증상은 아무런 징후가 없는 심급성 폐사부터 CNS와 관계된 운동 장애, 마비, 그리고 옆으로 눕는 증상까지 다양하다. 부종병은 보통 젖을 뗀 지 1~2주에 발생하며, 일반적으로 집단에서 가장 건강한 동물이 포함된다. 이 질병은 수유하는 돼지나 어미 돼지에서도 가끔 볼 수 있으며, 평균 질병률은 30~40%이고 감염된 돼지 중 사망률은 종종 90%까지 되기도 한다. 특히 부종을 일으키는 원인균인 병원성 대장균 STEC는 감염 시 높은 폐사율을 나타냄으로서 농가에 심각한 경제적 손실을 초래하고 있어 중요한 질병으로 확인되고 있다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 자연 친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
그러나, 돼지의 사육에 있어서 중요한 문제가 되고 있는 병원성 대장균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 병원성 대장균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
이에 본 발명자들은 병원성 대장균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 병원성 대장균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 병원성 대장균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC10을 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지 EC10을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 EC10을 인간을 제외한 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 병원성 대장균(pathogenic Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC10을 제공한다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 EC10을 인간을 제외한 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 EC10을 이용한 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 병원성 대장균에 대한 특이성이 매우 높고, 상기 박테리오파지 EC10은 병원성 대장균에 감염하여 병원성 대장균 내에서 100배 이상 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 EC10은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EC10은 병원성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 박테리오파지 EC10의 Stx2e 병원성 대장균에 대한 반점 분석법 수행 결과를 나타낸 도이다.
도 2는 박테리오파지 EC10의 Stx2e 병원성 대장균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3는 전자 현미경을 통해 박테리오파지 EC10의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 EC10의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5은 박테리오파지 EC10의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 EC10의 열 안정성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 EC10의 Stx2e 병원성 대장균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3는 전자 현미경을 통해 박테리오파지 EC10의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 EC10의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5은 박테리오파지 EC10의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 EC10의 열 안정성을 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 병원성 대장균(pathogenic Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC10을 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명의 박테리오파지 EC10은 병원성 대장균에 대해 용균활성이 탁월하다. 본 발명에서 상기 병원성 대장균은 장출혈성 대장균(Enterohaemorrhagic E. coli, EHEC), 장독소성 대장균(Enterotoxigenic E. coli, ETEC), 장침입성 대장균(Enteroinvasive E. coli, EIEC), 장응집성 대장균(Enteroaggregative E. coli, EAEC), 장병원성 대장균(Enteropathogenic E. coli, EPEC), 및 시가독소 생산 대장균 (Shigatoxin producing E. coli, STEC)으로 구성된 군으로부터 선택된 1종 이상일 수 있고, 바람직하게는 시가독소 생산 대장균, 장출혈성 대장균 또는 장독소성 대장균일 수 있다.
본 발명의 박테리오파지 EC10은 200 nm의 크기로, 정이십면체의 머리를 가지며 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였으며, 단백질 패턴 분석 결과 70 kDa, 50 kDa, 37 kDa, 그리고 33 kDa의 단백질을 포함하고, 또한 상기 박테리오파지 EC10은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.
본 발명의 박테리오파지 EC10은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 EC10은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 병원성 대장균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 EC10을 병원성 대장균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 EC10을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 EC10은 양돈 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 박테리오파지 EC10으로 명명하고 2016년 7월 1일에 한국미생물보존센터에 기탁번호 KFCC11669P로 기탁하였다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명의 박테리오파지 EC10은 병원성 대장균에 특이적인 사멸능을 가지므로, 다양한 종류의 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다.
본 발명에서, 병원성 대장균에 의한 감염성 질병은 유행성, 급성 또는 만성으로 발병하는 전염성 질환을 통칭하는 대장균증을 의미한다. 본 발명의 용어 대장균증이란, 가축에 병원성 대장균이 감염되어 발생하는 질병을 의미하는데, 증상으로는 패혈증, 설사(신생기 설사 및 이유후 설사), 독혈증(부종병 및 뇌척수혈관증) 등이 있으나, 이에 제한되는 것은 아니다. 병원성 대장균은 가축의 장간막, 위, 앞머리와 눈꺼풀의 피하조직, 후두, 또는 뇌를 통하여 감염될 수 있다. 본 발명에서 병원성 대장균에 의한 감염성 질병은 설사 또는 부종병에 의해 발생하는 출혈, 부종, 혈관내피의 손상, 혈관 내 응고, 미세혈전 등의 증상을 제한 없이 포함한다.
본 발명에서 상기 감염성 질병은 장출혈성 대장균(EHEC, Enterohaemorrhagic E. coli), 장독소형대장균(ETEC, Enterotoxigenic E. coli), 장침입성대장균(EiEC, Enteroinvasive E. coli), 장응집성대장균(EAEC, Enteroaggregative E. coli), 장병원성대장균(EPEC, Enteropathogenic E. coli), 및 시가독소 생산 대장균 (Shigatoxin producing E. coli, STEC)으로 구성된 군으로부터 선택된 1종 이상의 균주에 의한 감염에 의한 것일 수 있다.
본 발명의 약학적 조성물은 1 ×103 내지 1 ×1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 ×106 내지 1 ×109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU(plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.
본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 EC10을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감음성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 동물에게 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 EC10은 기존 항생제에 비하여 병원성 대장균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 사료 첨가용 조성물을 제공한다.
양돈, 축산, 수산업, 반려동물 산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 동물에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 EC10을 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 동물의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 EC10을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 유지류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 EC10을 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 EC10 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 병원성 대장균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 소독제를 제공한다.
병원성 대장균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 EC10을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EC10을 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 EC10은 병원성 대장균에 특이적 사멸능을 가지므로, 상기 병원성 대장균에 노출되었거나 노출될 가능성이 있는 동물의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 EC10을 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 방법은 병원성 대장균에 의한 감염성 질병, 예컨대 설사 또는 부종병이 발생한 개체에 박테리오파지 EC10을 투여하는 단계를 포함한다.
본 발명에서, 용어 "개체"는 인간을 포함한 동물, 바람직하게는 인간, 가축류 또는 반려동물을 말하며, 가장 바람직하게는 돼지를 의미하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 인간과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 조류, 어류, 곤충류, 포유류를 모두 포함하는 개념이며, 상기 가축류는 돼지, 소, 닭, 말, 오리 및 개로 구성된 군에서 선택될 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 EC10 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 개체의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 EC10 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 EC10의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예
1:
신규한
박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리
병원성 대장균에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 반점 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 돼지 농장 부근의 하수로부터 시료를 채취하였으며, 박테리오파지 분리에 사용된 병원성 대장균인 시가독소 생산 대장균 (Shigatoxin producing E. coli, STEC)은 (주)옵티팜에서 야외 시료로부터 분리 동정된 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 병원성 대장균과 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 시료 여과액에 대해 병원성 대장균이 접종되어 있는 LB 플레이트에 전처리한 시료를 점적하여 15시간 동안 배양하여 스크리닝하는 반점 분석법(spot test)을 수행하고 그 결과를 도 1에 나타내었다.
도 1에 나타낸 바와 같이, 병원성 대장균에 대해 용균 활성이 나타나는 시료를 확인하였으며, 용균 활성이 확인된 시료에는 병원성 대장균을 용균할 수 있는 박테리오파지가 존재하는 것으로 추정하고 용균반 형성을 확인하였다.
용균반 형성을 확인하기 위하여, 전배양된 병원성 대장균 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 LB 탑 아가(top agar) [LB 배지(트립톤 10 g/L, 효모 추출물(yeast extract) 5 g/L, NaCl 10 g/L) + 0.6% 아가]에
첨가하여 잘 혼합한 후 미리 만들어둔 2% LB 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(병원성 대장균) 배양액 150 μL에 혼합한 후 0.6% LB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% LB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% LB 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 LB 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, LB 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.45 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 3-4 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 병원성 대장균 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예 1.1에서 확인한 병원성 대장균 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x107 PFU/mL로 희석한 후 전배양된 병원성 대장균(STEC) 1.0x1010 CFU/mL과 혼합하여 MOI (Multiplicity of infection)를 0.001이 되도록 하여 35℃에서 120 rpm으로 9시간 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 EC10(Bacteriophage EC10)"로 명명하고, 2016년 7월 1일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 기탁번호 KFCC11669P를 부여받았다.
실시예
2: 박테리오파지 EC10의 전체 유전자 분석
박테리오파지 EC10의 전체 유전자를 분석하기 위해, 박테리오파지 EC10 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액 (Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국).
시퀀싱 결과, 박테리오파지 EC10의 전체 유전자의 크기는 170,197 bp이며, GC함량이 36%, 전체 ORFs의 수는 270개임을 확인하였다. 분석한 박테리오파지 EC10의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예
3: 박테리오파지 EC10의 형태학적 특성
박테리오파지 EC10의 형태학적 특성을 알아보기 위해, 그리드를 고정한 뒤 0.01%의 BSA 용액 (Bovine serum albumin) 10 μL를 처리하고 10 초 후 필터 페이퍼로 제거하였다. 준비된 박테리오파지 EC10을 10 μL 취하여 그리드 위에 분주하고 1-2분간 방치 후 필터 페이퍼로 제거하는 과정을 2회 반복한 뒤, 포스포텅스텐산(phosphotungstic acid) 용액 10 μL를 시료를 처리한 그리드 위에 처리하고 5분간 방치 한 후 필터 페이퍼로 제거하는 과정을 2회 반복하여 염색한 다음 투과전자현미경 (Carl Zeiss transmission electron microscope, 80 kV, 120,000~200,000)으로 검경하였으며 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 EC10은 전체 길이 200 nm의 크기로, 정이십면체의 머리를 가지며 수축성 꼬리가 있는 형태인 마이오비리대 (Myoviridae)에 속함을 확인하였다.
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4: 박테리오파지 EC10의 단백질 패턴 분석
박테리오파지 EC10의 단백질 패턴을 분석하기 위해, 1.0x1010 PFU/mL로 준비된 박테리오파지 EC10 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 EC10은 70 kDa, 50 kDa, 37 kDa 및 33 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예
5: 박테리오파지 EC10의 다양한 세균에 대한 감염성 조사
박테리오파지 EC10의 다양한 세균에 대한 감염성을 조사하였다.
우선, 박테리오파지 EC10이 야생(양돈 농장)에서 분리한 병원성 대장균(STEC), (주)옵티팜)에 대하여 감수성을 나타내는지 여부를 소프트 아가 오버레이법을 통해 확인하였다.
병원성 대장균에 대한 용균활성 확인 결과, 박테리오파지 EC10은 STEC 병원성 대장균 30 균주에 대해 감수성이 있는 것을 확인하였고, 이는 박테리오파지 EC10이 병원성 대장균에 대한 용균활성이 우수함을 의미한다.
또한, 박테리오파지 EC10이 다양한 세균에 대하여 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 1에 나타내었다.
상기 표 1에 나타낸 바와 같이, 병원성 대장균 STEC 외에도 다른 미생물을 대상으로 감수성 검사를 진행한 결과, 박테리오파지 EC10은 병원성 대장균 O114, O148, O157:H7에 대해서도 용균활성을 나타내는 것을 확인하였다. 그러나, 비병원성 대장균, Salmonella Typhimurium, Bacillus cereus, Listeria monocytogenes, Lactobacillus plantarum 등에는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 EC10은 병원성 대장균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예
6: 박테리오파지 EC10의 pH 안정성 조사
박테리오파지 EC10의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 1 mL로 분주하여 준비하였다. 1.0x1010 PFU/mL로 준비한 박테리오파지 EC10 배양액 10 μL을 상기 용액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, pH4-11의 범위에서는 박테리오파지 EC10이 2시간 동안 안정한 것으로 확인되었으며, pH2에서는 박테리오파지의 수가 3 log, pH 3에서는 2 log가 감소됨을 확인하였다.
따라서, 본 발명의 박테리오파지 EC10은 pH 4-9의 범위에서 안정함을 확인하였으므로, 박테리오파지 EC10은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
실시예
7: 박테리오파지 EC10의 열 안정성 조사
박테리오파지 EC10의 열 안정성을 확인하기 위하여, 다양한 온도 범위 (40℃, 50℃, 60℃, 70℃)에서 박테리오파지의 수를 측정하였다. 박테리오파지 EC10 배양액 (1.0x108 PFU/mL) 5 mL을 멸균된 튜브에 분주한 후 박테리오파지를 첨가하여 2시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.
도 6에 나타낸 바와 같이, 40-70℃의 범위에서는 30분까지는 안정한 것을 확인하였다.
따라서, 본 발명의 박테리오파지 EC10은 내열성이 우수한 박테리오파지임을 알 수 있다.
상기 실험으로부터 박테리오파지 EC10은 병원성 대장균에 대한 특이성이 매우 높고, 병원성 대장균에 감염하여 병원성 대장균 내에서 100배 이상 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 EC10은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EC10은 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 EC10을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예
1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 EC10 1 ×106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으
로 제조한다.
1.2
액제의
제조
박테리오파지 EC10 1 ×106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 EC10 1 ×106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
SEQUENCE LISTING
<110> Optipharm.CO.,LTD
<120> Novel pathogenic Escherichia coli specific bacteriophage EC10 and
antibacterial composition comprising the same
<130> 1-25P-1
<150> 10-2016-0169594
<151> 2016-12-13
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 170197
<212> DNA
<213> bacteriophage EC10
<400> 1
ttaggccgca agggccttca tagttttagc gatttgggaa acttcatcat cacttaaaga 60
attgcgataa ccgatgaagt cggaaacaat acggaatttc ttggtaaact cagcaaccat 120
tttatcactg ttttttgaag cattatgtga taattcatca aaaagattag ttactgtcca 180
gatgtcatga ccgatggtat cttttccacc gttgaaatat ataccctgca atgaactaac 240
catattacca aggcgagtat attcttcgga aacttcatct acactgaagt acttcatcat 300
aaaatctagt tcaggatact tgataatttt atcaatatat cgtttagctg aacttgaata 360
acctacatac ttatcataat ctacagcatc aaaagcatct acatataaat cacgcagagt 420
ttcaaaaata cattggcact gaccaagttc ttttaccttt ttctgcaaaa gtggacgaat 480
aacataaaat tcattaatgc caataagatt agccatacgg gtcaaaatac tcgtagatgg 540
attacaaagc gatgtagtac catccataga gaaaatatca gaacgatgca tatatgctac 600
ataaccagta atttcatctg cttctgatgt gagcgtaaac agttcctctt tttcccagcg 660
tccgtcttta atttcaaact taaatgcagt agcagcttta ggacgaggag ctgtactttt 720
tactgccttt ggaatataac ttttaactaa agcttcaatt tctgacaaat aatgaatgtt 780
aacttcatca ctttcaaaca ttgccataat atcaggaagc aaatcaatct gcgattctac 840
ttccggatta ataaacagaa gacgctcgtt gtgatgaata tttaaggtgt tattaaattc 900
gctatcatct aatgcacgtg ctaatccacg gacaatatta acacgatttt tagtattatc 960
aataacaata ttaatttttg tcgtattaat accaaacaga cgatagcttg acgcaacagc 1020
tgaagtttca tggctttgct taatgcgttt cagtcgaggg tcaagattta cttcatacac 1080
aacccctgca ttgcataact tactgtcagg ttcaaacatg ctctgcatct ttttatatga 1140
cagattttta gtcgtgaatt tgactgaatt gctaatcata taatctcgag cagaatatcc 1200
catcttcatc aattcacggt atgtatgacg aggagatgta gattctttaa atcgttttac 1260
atcttcatta aacgcccgct cactgagctc tttaacacgc tcaataatat ttttacgagt 1320
acgatcatct agtgaaagag cctcacgcga tggagcaata tcaagtgaac ccattggaaa 1380
cttaatgtaa ttcacttcat tgcggatgct taaccagtta cggtctctaa taacaccatc 1440
gataggataa acaataccgc catagatagc atacaatcca ccacgatctg gccaatatct 1500
ttctggattt acaccgtaat agtcatcaaa atccggaaaa taatcaattt cgcggtcaag 1560
accattaatg atagccaaat ctttgaatgg tcgcatgata taagaaactt cataagcaaa 1620
gtttctaaag tctttttctt caactggaac tacgatttca ataccagttt tatcatttgg 1680
acccatttct tttacgaatg taggtttaat ctgcggacca tcaccatcca tgtaagctac 1740
ataaccgcga atttcacctt tatgatatga agtaatacta aatgtatcag tataactaaa 1800
cggagattta gaacctaaac caaatccgcc aatgaaatcg ttagattcag ccttagatga 1860
actaaagtat gaattataca acccaggaga attatcatca ccctgaatat caaaatcgct 1920
catacccgga ccaaagtctc gacaaacaaa tcgcgggtct aatcgtcccg gaacttgaat 1980
gataaatttt tcaggatttc cattgagagc atgggcatca atcatgttgg taatcaattc 2040
acgaactact gcgcgaatct tgtttgtata caaatcagat gacagaattt taaatacttt 2100
aggatttgct gcgatgctaa atgcctttga tttagaacca ttaccaagaa ttgtttcttt 2160
ttcagtggtg ataatcataa tttcctcatt aattcatatt gcgtttaata acttcagcaa 2220
cttctagtag ttcatcttta gttgcggtgt cggattgaat tttatctcta atatccttaa 2280
agcggttttt aaactcttcg gcttctccca tatcgaaaaa gcgttgaatg attctatatt 2340
ctcggtgaac tgctttatca aaaagttcta aatttacttt atatgatttc atttcaatat 2400
cctcatttgc ccaattaatt ataccacatc cttgtggtaa agtaaactac tggctcatcc 2460
attctttacg aaggtcagca ttatctccca tgagcatttc aaaaagttct ttccaattct 2520
caggaagttt aacaacatca tatactggat tttgaatcat ctcacgatat tcagattttt 2580
ccaaagagcc aagtccctta atataacgga tgctatgttt aggtagagca tctttagcac 2640
tctcatattc agcgactgta taaaaccatt cttgtttttt accgacctga gcgatgatta 2700
caggagtttt gacaaagcga attcttcctt gttcaaacag ttctggccaa ttactaaaaa 2760
atccgagcaa agaaggataa atgcttccta gaccatcatg gtcagcatca gtcataatag 2820
caatattatg ataattcaag ttttcagctt tttcaccaag aactaatcca gtgattgcgc 2880
aaatatcaaa cagttctttg tttttaagca tatcagcata tgacataccc caactgttaa 2940
gaactttacc acgcaatgga taaccaccat gaagttcttt atcacgaaca tcaataagat 3000
atccgatagc agaatcaccc tcagtcaaga aaagagtagt atcagcatct ttaccacaaa 3060
gattcgcttt gatatgttta tgaaccttag ctttagaggc ctttttagct gctttagttt 3120
ctgctgcctt ttctgccgcc aatttacgag ccaaggcagc ttcaataatt ggcattaaaa 3180
ttgcttcatt atttaaaata gcacgtgaaa tctttttagc atcaagctga atatgactac 3240
ggatttcacc aaatggagaa gtcagacgct ctttagtttg agaatcaaat cgcatgtttt 3300
tcatatcacg aacaaacata acgatagtca aacattcttt aacacgtgct ttagttacgt 3360
caattttaaa tttacgtttg atttgtggaa taaggtcttc acaaatatca tccataacac 3420
agtcaatgtg atggccacca ttcttagtat gaatgttatt gacgtacgtt aattgacgaa 3480
aaccatcagg tgaacgacca accgcaatag aacaattttc ttgttcttga acgatagcat 3540
gctcatcata ttggcgcgca tatttcttaa aattaccctg aaccttttta ccattaaagg 3600
taaattgaat atcaggataa actactgcaa gtgtctggag acgatccagt gtaatgtcaa 3660
gataaacttg agatagctca ttagtttcaa atgacataaa atcaggaatg aaagtaacgc 3720
gagttccttt ccattttcca ggaatagttt cccatgattt attttccatg ccatttgaac 3780
aacgaactac aatattattt tgaccgtcgc cagtttcacc gacaaacatc acagaaaaaa 3840
tgttagttaa actagaacca acaccgttca taccaccagt gacgcgttct ttatcatcac 3900
caaagttacc acctgctttt ggaatagtcc aggcagcaac aggaccagga atttcttcac 3960
cagtaggtgt tttaaccatc gcttgtggaa taccacgacc gttatcttca actgttactt 4020
gattgttttt gatagtaaca ttaattttat ttgcgaattt aaacttagta cgaatacctt 4080
catctactga gttatcgata atttcatcaa taagcttaac aagaccaggt acatactgaa 4140
cactttccca tttaccaaac agaaagcgct catgcatttc attagcagaa gagccaatat 4200
acatgccgct acgctttttg atatgttcaa tatcgctcag aattttaatt tcattcttaa 4260
tcatcactta tcctcgtttg gtttcgggaa tattatactc cggtaatcat aaagctaaag 4320
gcccgaaggc cttttattta aaacggatag tcgaatcttt gaagaataga ccagaacata 4380
cggttccttc tactttctgc ccggtaggtc caatagcacg aaatccagta tgctggaaat 4440
cattttcaga gcaaccgaac caattatatc cagtgatttc aatattagta aaaccacttg 4500
aagacaaaac tttggttgca ttatcagcat cagtacatcc tactaaagat actgctaata 4560
ctaatgccgc gatagaacga ttaacatatt tcataatttc actcaaattt aatggcttga 4620
aggagactaa taattctcaa gcgacttctt tcatctttaa ctgtaaaaga aagagggtcg 4680
ccagatttca tagtgatggt gcatccaaaa tcaaaatctt ctgtaacttc ttcgaagaag 4740
tcaaattctt catcataaat tagaacatta ctctgaaaac tgtgaagaat ttttccatca 4800
tttccagatg ctgtactaat cattgtaaca ttatggcctt tcatatcttc aacgataaat 4860
tcgcttgtag atattacagc attaatagaa ccattcctat aaatagcaga cattagatat 4920
ttcttttctt caccttcgcg aacacgatat ttcttaccga ttttaaacat aatcaccctt 4980
taagtaagtc gtaaaaacca ccatttacat gcttaggagc agaaggccga cgagtagaca 5040
aacgatgaca tttagggcaa acatcatttt ctcgttcaga aatcttttta attttttcat 5100
attcatgccc gcaatcttcg gattggcatt tataatcata cattggcata attattcctt 5160
aaagtgtgct ttcaacatct ggtacaagga ccatgcctgt tcattatttt caatagtaac 5220
tttcatgaca ggaaattctg tgaaatcttc tatttgttct tgctcttcct gctcttgttc 5280
ttcagcagcc tgatatggat tttccacttc atcaaagaac ccagcttcgt tagtagagag 5340
ccagataaag ttttcgtcaa ggatatcacc atgtgttgca tatccaactg tgccagtaga 5400
tgtcataatt ttagtaggac gcccaagata atcagcatct aaaattttaa aaggttccat 5460
acctaaacgt cgtgcataga ttccgttatc agtatggtct ttaataaaat tttcttgagc 5520
ttgtttattt ttaaattgat accatttatt aacttcaaat ttaatagcca ttaataaatt 5580
tccttccagt aagttgtgcc atcttcagta atttcacgaa atacaccgta aattggctgt 5640
ttatcgccga ctttctcata cacataaacc gaagtcaagt gagtaaactt aacagtatgt 5700
tccttttgaa ccactaccaa atctggatcg aataatacat cttcaaattc gtcattagtg 5760
cagttctgaa caattttacg tttcattaca atttcctcat taattgaaca gtggagcgat 5820
gcgtttcaga agagtagcag cacctttggc gaattttaca tcatgaaaaa cagtttcttc 5880
ttctgttaca acacgaactt taatgttttc acaatcccaa tttttacgaa caatcttcaa 5940
aagctgcagt gaatctttac attcagcaat atcgataaca catccacgag aatcttccat 6000
tatcgcacga taaccataag ccataccata atcgttgaaa gattgttcga tgataattaa 6060
gttttccatt ttattctcca agttgttttc tatatcagta gttgatattg atatagtacc 6120
ataatcaact actgatgtat atagttttat gaaaaaattt taaactttat gcatagagcg 6180
catttctata gtgtttaatc caactttcag gaatgacttt gtatgttcct aaaaatacca 6240
cgttgtacaa cttaacacca tcttctaccc attgatcggt aatgtatcca cacatagcac 6300
gagtataaac agcctttcca tcatctggaa tgaatttaaa ttcgcaagga gcaatgaact 6360
taatagattg accgagtttc cacttaaagt ctacacctac atgcgaagta tcaatcgtct 6420
caattccttt agcgggaaca gctttcaaaa acgcagattc aagaaatttc gcgcgaacat 6480
aaccaaactg aggtttagac tttccatctt taggaatgat acgaactttt acttcagaat 6540
cttcatcttt aacaccgtgt ttaagctgaa tgcttacaat ttcgaccaat tttcctgctg 6600
ctttagaacg ggatttatca gatacacgag caatttcacc aatattaata atcatagtta 6660
tctctcactt gttaaaaaga ttttatactc cacgggacca ttatactctg gtcccaagag 6720
tttgtaaact attaattcaa aatagctacc actgcactac gaggtactac gctaaaatca 6780
cctgcatgaa caacgttcag aagttcaaca ccatcttcaa tccactggtc tgttacccaa 6840
ccacagaccg aaataaatgg ggtcttaata gctactgcac gagttagaag gtcggtaggg 6900
tcttgttctt caacttcttg gaacaggatg aactctgctt cataaaccag gattttctct 6960
attttgttat tgtctaaacg acgaccgtgg acaatataag atttagtaaa ccatttactt 7020
ttttcaaagt cttcaacggt aaattcgcct tcgccaaaaa catcagtcaa agttttatgg 7080
ccggaaatca aggcattagt tttaatttca ggttcaacca gtttgtaggt tttgccgatt 7140
tcaatagcag tagtcatagt aggttcctta atttccagtg gtttaacagg gcatacataa 7200
gtgcttacaa catcaaaatc aatcagttta gctaccggat ttggtgtgta ttcaggatta 7260
taattaaatt tcatatttat ctcatttcaa taaaatctac gagttcagca tgcgatttgc 7320
ggaacattac ttggtgcccg ccaatgataa cttcatcttc aggaacttca tatacagcga 7380
gataaaatcc tttagaagat aattcttccc gctcttctcg tgtgaaccat ctcatcatat 7440
catattcact agcgaaagca aaatgataaa gagctataaa ccatcctgga atatgatatt 7500
ctactccaac ataatctttc ttgaacttag tattaattac tatattagcg tttttaacta 7560
atagtttatc ttcatgtggt aaaggaattc ttttattatt atcgctatga tgcataaaat 7620
taggtctgtc ataacctacg tgtaatagcc actcttcact ccatgaatct attatactcc 7680
tgtacggcgt tatttgaaca caaagatttc gacgtattgt tatagcatct tcataatcaa 7740
gaatactaaa cgatgattca acacgataaa ttttcatttt attatcctca gtagctatgg 7800
tgttataata ccacaactaa ccgaggaagt aaacaacttt ttatcgtttt gttggaagag 7860
acagaggatc gcactcttcc tctgatggag catcttcaag acccatagca tatcgcaaag 7920
catacttcat catcaggatg tctttcgcac agtcatgaat agaatcatgt gcaacgaatc 7980
catctaaagt tccctttgga agaggacacg tggtcatatc acgaacaagc agaagtgctt 8040
caattctggt acgaatatca cgctgattcc agaatttaca tggttctaac ttaaatgtgt 8100
caagttcatt ctcagaaacg ccattaagac gttgaatatc acgaatgaga tcgactaaaa 8160
ttggaaaatc aaacgacatt ccacggcacc agccttgaga tttccaagga tcgatgttat 8220
gtgcattgat gtaatcatta aattttacaa taccatcgat agtgcttaca tcttcatctg 8280
atggtgcaat attttttcga gcttcaggag actgattttt ccaccattcg atagtgcttt 8340
tagtaaaaag acgatgtcct ttttggcttt ttaaatcaaa tttgatttta atgccacgtg 8400
aaactaattc atcaaatgtt tcaactactt ctggattagg gtcaaaggca ataacagcca 8460
aatcaataac agctgccttt tcaccgcttc ccattgtttc aaaatctata ataaaatcaa 8520
acattaaatt ttcctcgcta aatcgcgaat ttgacctaca gtataatctt ggatataaac 8580
tttattaatg ggctcatcaa taaattttgc catagattca atatcttttt gtatctcttc 8640
aagactgtat actatcttta aagctttttc gcgaatagta acattatcag gtcctgaatt 8700
ttcttgaatg acagctttaa catttgccat aagagattta aactgatgca aacttaattc 8760
aatcattaat aaccgcctta taaagatggc taatttcgcc taaaatataa tcactgattg 8820
taacagtttt cacttcacca caaaagaatt ctaacgcaat caaatctcgt tcaatttctt 8880
ccaattgaag cattaacttg cctgatttaa tttttacatt tgtacgattt ttactataag 8940
ctatttcata aatttcgctt actttatctt gaagtaaata aaactggtct ttagttattt 9000
ccacgaatag cttcctcaaa tttaatcata cataaaacac atcataacga ccacgagtga 9060
caccaacata aagaagctgc tgagctagtt cagcatctgc ataatggata caaggcgtat 9120
agataaaagc acggtctaca gacatgccct gagctttatg gaatgttgat gcaggaagtg 9180
ctttcacttt actaaactgc gatttagcat cccaaaaatc actccacgga gcttttccgc 9240
ctttattcca atttttataa gtttctgccg ttttacctaa aaataagtta aacttataca 9300
gctcttcatc agatgaaatt attttaatct tttcacgata atattcatca tcgccgtaag 9360
tttctactgt taaatcccaa tgacgaatta gatattctcc aggaacacca cgagctttaa 9420
caaatgttga tgtatactct gcttctataa tacgaactaa ttgtccgtta ttaaaaataa 9480
tttctgacac aggctttcca tcaattttat atgttttaat taatggttcc tgcattacaa 9540
taatttcacc gacaataaaa tctttatcag tttcaaaaat ctttttgcga ataatgctat 9600
ttaacttatc aacagattta ttcgtaaatg ccattacgcg attttcaaac aaatcatcta 9660
gtgattttac gattgaaaaa taatttacca taaaatcgcg taaagcggta tcaccagtaa 9720
atccacgtac tccatgcccg tcaacaactt tatcataaat ccacttaccg ttgcgaacat 9780
cagtagctac gtcaataata ggagcattac tgcgtttaac ttcagtgagt tcacactgat 9840
aaaaatcttt gtgcgtaaag aatggactga tataagcagt gttttctcct gggtcaacag 9900
gtctaatttg cttattatcg cctattccaa ttatagtaca ccaaggtgga atagttgaaa 9960
gcagaatttt aaatagcttt ctatcataca ttgatacttc gtcgcagatt aatactctgc 10020
atttagccaa atccggtact tctttttgct caaaaagaac gttttcttcg tatgttactg 10080
ggttaatttt aagaatactg tgaatagtac tcgcttcttt ccctgacagt tttgaaagaa 10140
tctttttagc tgcatgtgta ggagctgcta aaataatgcc agtttcgccc gtagatatta 10200
aggcttcaat gatgaactta gtaagagtag tcttaccggt accagcaggt ccattaatag 10260
ttacatgatg tttcttttct ttaatagccc tcataacgat gttaaaggca tttttctggc 10320
cttctgtcaa atcatcaaat gtcatcgtaa attccctgaa attggtatac taacaatacg 10380
cccagtatct aaaattcgcc gatataatct ttgtgtgtct acatcaggct taacatgttt 10440
aacttctatt ttattaaacc aaaacttgcg tggagtctca actaatctcg gaattcccat 10500
acctaaagct agtcgatact gctctttaag agtagtaaat actttatcag caatctccct 10560
ttcaaaaaat acagcaggac gatgttcatc aagaggaaca ggcaccgcaa atccatcttt 10620
atctctatac actatcgcat atacataaaa catattatcc tcggataagt ttaaaaattg 10680
aacaatttag cgggtatcct cttttcagtt taagtttatc aataaaagac aagttttgat 10740
accgctctac accttgaata attttatcac acatatcata ttgcatttct gcttctgaca 10800
actttttcac agttttccaa tccgagcctt taagaagaac gttcagttta acaacttcag 10860
cgccttctgc tatacgagaa ccatcaatac gagctttaag tgctataatc gttagcttaa 10920
tgtcagaggt ttgttttgat ttagaaagct gagaaatgtg ttcaattcgg ttttcacgtt 10980
ttttctgtat agctttaatt tgattataag tctttttgat tttagcccat ttcttttcat 11040
ctaaatttag tttatgaact tttttcgcag atgaacgacc aattcgcaaa gcaaataaat 11100
cacgcttttc aatcaactct tctaaagtat aatcagaacg aaatgtatta tactttttct 11160
ttacagcaat aacattccct ttaatgtatc caacgttatt atcaaaacgt tctaatgata 11220
atttctctcc ttcaatacga ttatcaaaag gttctcctga gtaagcgcaa actttctgat 11280
ctaaaatgtt cttaatgtaa ttgaagtcta agttaaaatc tttagaacgt cttttggcag 11340
atgcctgagt atgctctaga cgacgtgtaa ttttacgaat ttgattttta gacagtttca 11400
tatttttctc acggacggtt aactacttat actataacat ttttacttca gcttgtaaac 11460
aactttatga aaaatgcttt aaaactttca tggtataatg aatctaagtc cttccattat 11520
agattaaatc cttcaaagtc aagagtatag atggtgtatg ttgaatactt tttatactca 11580
tatctatctg caattctaaa tacacttcca gctggtatca ttacttcttg ttcatctgaa 11640
actaattcca tattacgata gcgatggcta tctggaaatt taaaactcgg actatattct 11700
ttacaacgta gagcttttat agcatactcc tgaaaattaa ataccatagg agctttgaat 11760
tcaaaaataa cttgcgtgtt gtattctaaa ccagaagcaa aatgtagagc tatattttta 11820
tcatatgaag ctgatactac tttatcaaat gtaataatat caatttcttg atttaacact 11880
tgcttagtct caactggaac acctctccaa agaggtttat cgtttggaac caaacgagat 11940
ttgattattt catttaacca agagtggtcg tctggcttat tagtaataca atgaattaaa 12000
agttcaattt cggataaatt aaatccttca gaaagtaatt cttcacgaat agaagcacgc 12060
accgatgcat ccattgattt gattttaaaa tcttttaatt gcattgctga atatttcatt 12120
caactacctc aatatcatac actttaaatg ttccaaatga atcgtgtaat ttttcttttg 12180
aaatagaagt tattttatac tttccaattg gaatcatcca ttcttgttca cgcacaatca 12240
tcattaagtt atcagtacgt tctgaatcta atccatcagt atcttcatat gtatacttaa 12300
actcggtatt aggagaagaa agtataatat cgctaatatg gtcagaataa ttaaaagctt 12360
tatcagtttt taagcgaaat attatttcag tgaaatactc aacataagaa aaaccacacg 12420
ctgtgtgcaa actagtagta aatgaatcta ctctgttcgt tgaaaacact tctccgactt 12480
gtaaatcttt aatgagttct tttgtcgatt ttgatatacc acgatatagc tgataaggcg 12540
atttagttaa atgcttttta acgattttat tcaactgccg atgaagagct tcattctttt 12600
tggcttccat acattgccaa agaattgact gttcaaagtc agtaaatttt tcacagactt 12660
ttttatacat atcatattga aaatcaacgc tttcagcttt tatagataac tgttcaacat 12720
ctgcaagatt aataatcatg atagcctcca tatacttcag aagctatcat atcattgtta 12780
ggaaggaaag taaacaactt tgtgaattat tttgcccatg gagcccaggg cggagggtca 12840
agatggtatg aagctagttc ttctagaaga gcatctgggg cttcaattcc ataattctgt 12900
aatactatac ggtactcttt cttataatca ctagaatcat tctggatatt cgtagaatga 12960
ttatcttcta acatctcaaa taaatccata ttaattccta gcgataaaaa ccaaattgac 13020
gattagcttc aataatcttt ctttcttctt cggacattct ccagcgtagt ccaacatcaa 13080
aatgagccca gaccatctta acaaatgcat ttatatcttt aatatcttca ataatgaatg 13140
ttttactttt agaaggttga ctcgctaatt taactttatc gtcttcaaac aggtcaaaaa 13200
gaccatattc atgagctctt ttatagcctt taatagttaa agcttcagaa gaagaaaatg 13260
gtgaatcagt attctgcaaa atatcttcag tatgctttat aattagaata acattttctg 13320
gatattttct ttcttttata tctttaatta aaatatctgg attttctgct aaaggaataa 13380
ttaatgagca ctctttatca agtgtattta ccgatttacc ttctttagac ataaattcta 13440
ttgaataatg ttttgctact tcaatcatgc gatttcctct tgcctactaa tgggccatca 13500
ggaattttgt tttcctggat atatttctca ttttcttcca tcattttact gccaatttta 13560
agaagcaaat ctaaagcttc atttgcttta gccttggcct cttctaacgt catatctctg 13620
ttcatgattt atccccatag atgtctctca tcaatttaag cgctgagcgt tctaatttct 13680
tttctttctc aacgctaatc attgatttca tccattcttc tgattcgttc tgcatttctt 13740
tatttgcttg ttcaacccaa ccatcatcaa tgtacattga gtttggtcta ctgaaccatt 13800
caagcatttt cttcagaact ttcatatgtt ttacctaaaa caacagtagg agcatcatca 13860
aattcatgaa tttttagcaa atttggatgt aaactattcc acacagaaga aataaagtat 13920
gataaagcat cttcactcac aattataaat ttatttcctt tatctatttt ccagctatat 13980
actgaatcat acgaatagaa agatagagga ttatcattat attgttctgc gctaacatta 14040
atgtattcgg atttagtaaa tgcttcaatt gctctaaatg gaatatttgg tacagtttca 14100
atgataccaa tctttttaag ctttatttca gcatcttctg gaactggcat tgaaacgaaa 14160
ttttctacga gatacattgg gtcacaataa cccttatcaa tcattactgc tactgtaatt 14220
ggaacatctt tagcaaacga catactattg ctactaatat acatttcaaa caaaatcgct 14280
tccataattt tcctcaatca caagatgtag atgaacaact agaatcgcaa gaacttccac 14340
atgaatcgcc cgtccataca tgaacaggaa cattagtgtc atatgaatca gaactagact 14400
gtgtattctg tgtattagat gatgtagtag gtgttgacca gcgccaagga tttttataat 14460
attcttgggc ttcttcataa gtcatagtaa ctgcttctac tgttccatct cccatataaa 14520
catattcaac tacagttaaa ggaaggtagt catttgaaat aggaactaca ccttctccgg 14580
gagttgtaga gaaaaaatcc gtaaagaaac ttttaaacca attaaagata aacattacaa 14640
aaagcctctc ttgaattcga cttgcttctc gccataatca tatcgaatct ctgcattaaa 14700
ttcgacagaa ccatctgcgt acatcataaa tgaatgcaca acaacttctg tagaccatgg 14760
ctgcagttca tatttcttca ttacatgccg tgaaatgata atatctaaat cttcatttgg 14820
tttaatccaa cgatttaaca tagtgctctc ctctataaga taattctatt ataccatact 14880
cattttggaa agtaaaccgg taaaatgaaa aaaggactcc cgaaggagtc cttgaaatta 14940
ttcaccagtt actttccaca aatcttcatt tgcagcaatc cattcagtac gttgattttc 15000
ttcatatact gtagaatatg ctgctttttc tgaagggaat gtctggtaat gagcgccaga 15060
aattttgtga acatcagaat aaagagggaa agctacagaa atttcctttc cttcaatttt 15120
cttatttcca tctaatttct gctcaaatgt tttgatatta acataaccgc gagtactagc 15180
catgtaattc tccttttatt taaattacat gattatttat aataaattct tgcggaacgt 15240
taaaataccc aattttagtt aatataacaa catcaccgtt aataactacc ggagaataat 15300
cggctggagc attaaacttc caatgggctc taatattata tccatcagaa ccaaatgctc 15360
gactagctgg tctaccggct ttttgccatg cataaaaatc aaatttcatt ttgaatgctc 15420
tataattaat tttaaggctt cttcatgcaa ccacttacct ggtatatgtc cagttttaat 15480
tgtgtgagct ttgtggagct gattagataa gagctcgtat gtgagctctt tgtcataatt 15540
tttaaatagc tggtcaatgc gtttcttgcg ggctttctta agctgacgtt tatttaaacg 15600
agccattaat aacctcgatc ttgacgagca aagttttcag catttttcag ataataaagt 15660
ttaaagattt cttcagccgt aagaccgaga ccttggaaca tgttcagaac gaaatgaaga 15720
atatcaatca tttcgaattt aatttccaac tggtcttgtg gagacaaatc agtaattaga 15780
gtttcacgac gttcaccatg ctgtgacttc caaggtttcc atacagcaga tgcatctttt 15840
tcaccattgc tcataccacc gagagaagtc agaagttcac ggaattcatc gtcgatataa 15900
tctttttgat tacgcagcca atcaacaact tcgcctgcag tagccaaatc atcaggatga 15960
cggttatatt caggtttatc tttagctaaa cgaacctgca aagatttctg catatcaagc 16020
ataacctgca gtgggtcttt ttcatcaccg agaatatccc agtattcatt ttgagcttta 16080
tcagcgcctt cgatcagatg actacattcg ttgaaatgtg gcatgttatt tttcctttct 16140
tatgaagttt tctatcatat gtctatagca gatattagga taacctgcct tgacagctat 16200
tttattaaat tttgtgcgct taggtctatt attataaacc cacaactcgt aaagcgaatc 16260
atacgaattc catatctcac cacgtcttgg attcggtaaa ccatatcgag gtgaattttt 16320
accgctaaat cttccttttc gggctttact catattagcc ctggcttcat cggatataat 16380
tttaccttta tgagctagac gcattttagc cttagtttct tcaggtgttt ttaacccctt 16440
tatccacgat ggttttccaa accttggatt attttcaccc gagaaaagag cagagttttg 16500
gattttaaga gtttctatta atctacttgt taatttaaca cctttattat atcgcattaa 16560
atttacagca taatgcaatc ctctcacatc tggatatatt ttagttaata atctatgagc 16620
tataaaatgc tcacgcgcag ttaactcaac aagattgttt ttgccatctt ctcctcccat 16680
acatctagga attatatgat ggcgttcttt atatccgcca agattccggc atttagcttt 16740
tgtaattaaa gccgagtaaa ttttttggta attcacatat atcctttcaa ttcattggtt 16800
aatagattaa ttatacaata aatatataaa gcaataagga ggacatatgg tacaaaaatt 16860
aatggcactt gttaatgcca taaaaggtaa taaaaaacgt atagctttta ctatttctgc 16920
tatggtagga attttactct ggaattttgt tttatcacca attgctattg ctcatggcgt 16980
tagtattcca gtaattactc ttgatacatt cgtagattta gcatttgctt tagttgggtt 17040
aatttaaatc ttagcatatt tagatagccg cattttagcc atcaaccctt gggcaatatt 17100
atttttcata tattccataa tttgttcagg ggttgcacct tcctttctaa tcatatcatt 17160
aacatctttt gatttccagg gagatttatc ccaaaacata accctttctc ctgcatcaac 17220
taatttagtc attcgtttaa tagtatcagg gtgacgaggt tcattatcta aaacccatac 17280
acgtctatct ttaaatggaa caatttctag gtctaattga ccacctgtaa tagctatacc 17340
atttttaata aaaagtgaat ctataggtcc ttctagaaca tatacatcac catctttaac 17400
tcgttcaacg ccatagattt ttgttgcttc aggataagct ttgatggtga tatatttttg 17460
aggagcatct ttctttaatg cacggccttg aaaagactca gcttttccat tagcattata 17520
aattggaata acaagacgag gctcaggtat ttccttttta tatgttcccg gtgctatact 17580
attaactaat ttaggccatt cggttgtaaa ccaaagatat ttccatttat cctttggaat 17640
acagcgagct tttacgtatt ttataattgg atggtcttcc gccagtttat ctaatctaat 17700
acatgacgga agagatttaa ttattttctt ctcaggttgt ttaggaagtt ctttgggttt 17760
ttctactgga cgacttttac ctttttcttt tcttatttca aagatatact cacgatataa 17820
atcaggttca aactccttta aatatattcc gattggtgca tgatagttac agttataaca 17880
atgaatattt ccttcattat tatcaccata ataccatcca cgggctttat tttggtcggt 17940
ttttgaatct ccacaaacag ggcatctaaa ccgcaattta aaagttgaac tattatttac 18000
ttgtgtgaat ttaggtaaat gagctaatgc acggtatgca aactcattat caatccaagg 18060
tattgatgac atttttactc ttctttttct ttagattcct cttttttctt tttaggaatc 18120
tgttcagggc ctttatttac tacagcacct gatgttgttc cagtagagat attttcagga 18180
ttaccgcctg aatctccagc gaccatatct tctttaataa attctttata tgttttcata 18240
ttaacctcta ttcataaaag cattaaaaat ttggtcatca atagactgtt tttctgatgg 18300
taattcatat ccacatatta caattttgtg atcaatatca aaatacacag aagcaatatg 18360
attaatgatg ttttcagtaa agtctaaatc aacatcaata tctttttgac cacagcccaa 18420
aggataaata atgcgagtaa ttcgattatc tttaacaaag attccaccga catactcagt 18480
gttacgttta aagtctacac gccgacgaaa tgaaaaatat tcaggctctt tatgagctcg 18540
gctcatagga cacaacgagt aactagagta agagatgtca aatcctacgc cttcaatatg 18600
agccaaagta tcatgattaa accaattata atcgtacgcc aagtccatta gattataata 18660
tgtaaaaggc accggattaa catcattagt cacaagcatg taattagcaa ctgctataat 18720
ttcgttgttt ttaacgaata caaaccgtga ttgatgcgaa tgacctggac ctgcgttttc 18780
acgattaatg atataacact gggcaccttt atatttgtat gtatctttgc acttgtgcat 18840
ttgataaagc attattcacc taccacttca gcgatgatat ttttattatt gaagttttta 18900
tcacaataca gaacgtaatt atactgcatt acaccaccag acttaagctg tttttgtact 18960
tcagctttca tttcagggcg atcacgctca acgatattca taatatctgc ttcaatctga 19020
gtttcaacct cagtctgatc tgcagtcata gaccattcgc acaaatcttt atcataaccc 19080
gccatagcag gctgagcagt acaagaagcc aaagcaaaaa ttgcagcaaa aacaaatttt 19140
ttcatgataa tctcctcagt agtttatgtt tatatagtat ctcaatttcc aacaaaagta 19200
aactatttta tttcctcaag ttcgttaatc aataaaagtt ctctgacgct aaaaacaaag 19260
aaaaatgtgt ttccatcaac cagagcatga ccgctaatag aacaccctct gcggaattta 19320
gaaacttcac aatctagaac tgtaaaaggt tttaatccta tgactttagc tgtgcgtcta 19380
ttcagttcac aaccacttgc gaatttttcc aaatcttctt ctgatttaaa ctgatattct 19440
ctattaacta gcatcatttt cttttctccg cgattagctg atagaattac tataacacaa 19500
ctctatcagc ttgtaaacta ctattttact agcatcaata actatttctc taacttgatg 19560
attttacgaa agtatctttt gcattggcga atctgtcgct tcgtagggcg cacagcaaac 19620
ttaataaatt ccactcgacc aaatggagga ctttcttctg ctggaatatc taacaccaat 19680
tcccacgtat ctgcaacaag tgctttgaat tgagtatttt tcctgacatt atacggagta 19740
ggtttaaata aaacaatatg catattatcc tcggcaatcc acttcacata ctttcttgtc 19800
atcaatgaaa gctttaacta gcgctttatt aacttcagca tattgagtag tagcccattg 19860
aacgtcatct ttcatcattg tgatttcttt agtaaacatg ctttcattct taaaccaccc 19920
cataaaaact acctttacca attccataaa aatctcctca tttaaccaac aagactacta 19980
taccatagtc ttgtcagctt gtaaactaaa attttaattc atttgccaaa gcatctaact 20040
gagctcgagc cgattcattt ctttgatagc ggttctgctc agcctgaatc tgctgtgaac 20100
ctgctacttc gttcacttca gttggagtag aatcttgttc aatttctacc catttctgat 20160
ttcctttttg aacgcccatc aaaaacttat tccatttatt cttatcacca tatcgtgatt 20220
tgatttgctt aatgagttgt tgttcagcag ctgctaactc ctcggtttca atgaccgcaa 20280
gcataaaatc ggctgttgct ggaagaccgg cagattctgc aatatcgctc atgttaacat 20340
cagaagaatc ccaagcttgc ttaccaacct gtgctgcggt ccaaagaaca gtttcggttt 20400
caacagccag agcacgcaat tcttctgcga tggctttaac agttgtgtaa ctattttctg 20460
aataaactct aatgcggcaa gatttacaaa tacccagata gtcaacaata atgattgttg 20520
gaacaaaatt cttcttgagc tttaattcat ttaaaagcga ccgaaatgta ttagcgtctg 20580
ctccaccagt aggatattgt ttaacgatta aacgtccaag agtagatttc tcacgccatt 20640
tttccatttt tcctttatat tcagcataag aaatatgccc atcatcaatg tcatcaagag 20700
aaacatcaag catattagca tcaatacgct tagcacagac ttcttctgcc atttccattg 20760
aaatgtaaag aacattatgt ccgagctgca aataatctgc tgccaatgaa cacagaccta 20820
atgacttacc aacgttaaca ccagccatta aaacgttcag tgttccagtc tcagctccgc 20880
ctttagtaat tttatttaga attttgagtt taaatggaac cttacgagct ttattcatat 20940
aagatagcca acgtgcttcg tagtcatcca tccaatcatg accaacgtag ctatcaaatg 21000
aaattgataa tgcttggcgc atgatgtcag gaatagcacc tacatctggc attttcttat 21060
tgcgtttttc cggaggaagc tcagcattgg tttgaatttc aattatttta gatgtggcgt 21120
taaacatcgc cctttgctga acatattttt ctgtttcttt tactaaccag ctgtgatctt 21180
ctggagaatc ggctagtttt gaaataagtg tttttacacc agaatattct gtttcagtaa 21240
atgaactatt ttctaacgca acatttaacg cattaataga tggaacgcta tgatactcgt 21300
taacatgaga tttaattaat ttgaatgtat ttttagctgg accactttca aaatattctg 21360
aatccatata tggccaaact tttgaaaaat aagcttgatc aaatatgaga tgagaaagaa 21420
taatttctac cacacttact ccttaaaaga atttaaattt tttctttgac cttttattaa 21480
atgcatcttg tagttgcatt gtaatacatt tttctacatg aggagctaac tcagcttttc 21540
tttcttggtc aagaacagca aagtccatta cgacttttcc atcaacccaa tctaattttg 21600
tcacatacac aatgtgtgta gaaccgtctt ctagtttaat gacaatctcc tggataacat 21660
tttccatggc agatttaatt atcttaagag attcattaaa aagacgttct tttctttctt 21720
cttccccctc cgaagagggg gattcgtcga taatttctag atctaaatcc aaatcatctt 21780
tattcattaa attcttccat atcacttaac tgatctaggt cagtttctaa atcagctgct 21840
gatttacttt tactttctgg agatttaaat ttttcaacct ttgagttaat caattcatca 21900
acttcagctt caacaatttc attactatca atagcaccta actgataagc acgtttaata 21960
gcatctcgga atggttgatg cttaaataaa ggaccccaga atgtagtaca gttggtatct 22020
tttgcacgcc aagatttttc ttcgcgaatc atctcgccag tttcttcgtc aagaaattca 22080
cgagcatacc agccattttt aggttttacc acaaatccta attcaagagc catatctaac 22140
aatccagaat aaggatcgat gccaccgtca aatttaacat caataaagaa tttacttttt 22200
tctttaacgg tacgagattt ttctacattt agaacaaatt gatacccctg aagatcagaa 22260
ccatctttaa tctggcgctt accgataatg aatacagtat cagccgaata cattacgcct 22320
gtaccacctg tcatcacggt tttactaaac atttcaattg tttcaattgt atggttaacc 22380
gcaacacacg gaatgttttt aatactaaaa taaggagtaa caatacggaa taatgacttc 22440
agcgatttag cacgagtcat atctgccaca gatttttcat tcaaggcatc ttccgtttct 22500
ttcttagaag ccatattacc gattgagtcg atgaatacaa taactttttc accgcgctca 22560
atagcttcaa gctgattcac catatcaatt ttcagctgtt caactgactg aattggcgta 22620
tgaattactc gttccgggtc aactcccatg gatcgcaaat aagctggagt aataccaaat 22680
tcgctatcat aaaatagaca aaccgcgtcg ggatatttgt tcaaatacgc cgcaaccata 22740
gtcaaagaca tatttgattt aaagtgttta gaaggacctg caaaaatagt taaaccagac 22800
tgcataccac catcaatcgc acctgaaata gcgatattaa gcattggaat ttttgtacgg 22860
attacatcct tttcattaaa gaatttagat gtagtcagtt cagcagtcat tttagaagtg 22920
gaagctttaa tcaaacggga ttttaaatct gcaatagaca ttcatttttt ccataggcat 22980
cattatattt tcctcactgg ttaaagatag agtaattata acacaataaa tttaggcatt 23040
aatcaactgc tattggatga atagcattaa acttatgaaa cgcttctgat ttttctttgc 23100
gcgaaacaca catgcgaaga acctttaatg gctcgtcttc ttcacctaat gattttcgtt 23160
tttcaatatt agaagttttc caacgagctt gctctggaaa ctctctattg atttgctcaa 23220
gagctctatt atgttttgaa ttactacgaa ttgagctgca tccaccggga gcctgtgctt 23280
ttccagatac aaccagatat ttgaacaagg ccaaatgcgg ataaccttga ttaattaaat 23340
tgagaaatgc atacatatct tcgcataaat caatttttcc atacccaatt tgttctgttg 23400
taagttttcc gaggtcatac catgtattcg tgaatccata tgaattttca cgataattac 23460
cccaagatga agtaatttta aaaataggta aacgagcatg accatgataa tacccgcaat 23520
ccatggcatc ttcaacgtat tgaatcaatt catagaactg ttcacaagtt aattgattaa 23580
ttttatctac gcagcgacga tcatctttct ttcgcattga actcatacga atagtagtat 23640
catcatcaat catccaaatt cgctgacctg catacatatc agtaattgct ttacgagtac 23700
cagcaattcc attaacatca tcaggaatag ttataatttt agctctagac ccgtaagcgt 23760
cataataagc tttttcttca tgttcacgta ctacaatatg aggttcataa tcagtcggaa 23820
acatatcaag ggcagaaact gcccctacgc gttgatagct tggaattacg aattgaatca 23880
tttccactca ccgttataat cttttttcgc aatatgggtt tcgccagttt tccaccaatg 23940
gtcaaccaaa taaaaatgac gggaatacac atgaaggctt ccgacattcc atataatgga 24000
acctgcttta tactgacgag ttgaatcacc tgcattcaaa tcagatacta atttatctag 24060
tacgtatttt tgccatgcat aatcattacg gaatccgaag accacgtcat ttgaacgcat 24120
gcttactact gcattgactt tcttatcacg aatcagatac tgtactgtat tcgtacacat 24180
gaaatctgac ataccatctt tattgtagtc aaactgcatg gatggacgag tataaatcat 24240
gataccgcgg cgagaatcag gattttgacc aagttcagct aaacacatgt catactgagc 24300
ataattatct tctgaccaga tggcccaacc ataattcgag ttaatttcgc ctttagaaga 24360
tgctacctgc tgccaaatct tcggcgtttc acccggaata tctttaacaa acagactttg 24420
agacttatac cattcaagtt cacgctgaat gtattcatca ttaagagcgc caaaaataaa 24480
aggttcatct gctacaaatg atgcaccaat aatttcaata gttttaacac cggttttatc 24540
aattacaaaa tctttttcct ttaatgcaat tcccaaatga agacggattt cttcaactgt 24600
catagagtca ttaatcattt aaacctcaat tgatacattc atatttaact tgtaacagta 24660
ataaactcca ccctataata agcgttggaa tcatacaagg aactgctacg ctatagtata 24720
tacttattat aatcatcaag attaaaagca atactgctaa aattttgctt ttcattcctt 24780
ctctctgatg ataattactt gatttggctg tgttgacttt ttagtttcac ccgcaattga 24840
ccaaataaag gtaataaacc aaccaataat tgaccagtta aacagtaaag atgtgaaaaa 24900
gattcctact gtcgattttg acccacgcat caaggcgatg aaccatggaa gcatgtatat 24960
aataatagcc aacacgcctg aaactaaaac cataaaaatt gaacctgcta ctaaagtttc 25020
catgttttcc tcacttagtc aaatttttta cacatgaatt ataagaattc actacatact 25080
ccatcggagc atttttacct gtacgccatt ggtaattatt agcccaatta gcccaaagct 25140
cagcgcagta gttttcaatt ttttcttcgc gtgtaattac atctgaatta cgatatgctt 25200
gagcagattc atctggacga atagcttcat caaaattcgc ctgcatttgt tctactgtct 25260
gttttgaagc ctctttataa cacttaacat taggattata aaatttgctt gaacagttta 25320
caatttttcc tacatcagac tgatttacta ccggtccttg agctacacaa ccagtaagac 25380
ccaatgcaat aaccaaaata gcgattttca taataatttc ctcttaaaac ttaacaaata 25440
actttaaagc atcttcagtt ttaattcctt ttcttacacc cataacagaa attggttgtg 25500
actgaaattt tcctttacca ttataaattt ctaatccagt caccattcca ttttgttcta 25560
taataccata agtattacct tcattttcga attctttaac tttaaagagt ttattagctt 25620
tttctgcatt aacaactttt aaattttgaa taaaattagt ttgaacgttt ttcattttgt 25680
gttcctccgt agttgatagt tgtatagtac catggaagaa cagagatgta aacagttttg 25740
tgaaaaattt tttaatgaat tccagaggtc cagaatcatc tatttttcct aagtatagat 25800
ttatattact tgtatgaaaa aggaacccgg aggtccctag atttattcta tcagccaaac 25860
aggaagtcta acgaagcttt ttcctcatag tccatacctg ccgattcaca catacccgca 25920
agcggtttaa caaacgattt ttggaacaaa gttgagtagt caatccaaga cagtacgtca 25980
gaacgaattt cttttggaag ttctgtgccg gatggccaag caatgcactt gtcaccaaat 26040
ggatttccct cacgtaatgg aagaaccatt accttatttc catccaaaat tggagctaca 26100
cctaaaccac taacagctcg acgataagtt agcacaccac gaatatggaa cgggcattta 26160
aaccctggcc aacctttatc gtcatatttc gctatatcgt tcgcggtttt tacttcagca 26220
ataactttat aatcaagttg acggtattct ttctcaaagt tcttgtagta ttcttggaca 26280
gactcttcgc cttcctgaag aatacgacga atactttctt cgagagcttc ttgtactgct 26340
tttggtgttg aactctgctg agtttccata cccatgattt ttagatgcgg ttcagcaaat 26400
cgcttatctt ccatatcata aacgttcaga gcataacgtt ttttcgcttt ccaaaatcca 26460
ccgacaccct ttgaaccaag gggagggcaa gaaatagctt cacggtccat atgcatcaga 26520
tgctcgcggt tattcatata atcacataac tcacgatatg caacatcaat cataggttcc 26580
atctttttct taccaaactg attcatgaat tcaactaaat cattttgttc tttaaagcgg 26640
tcaagaccta ctttttcaat tactttatct acacaaacat ataccgaatc agtatcaccc 26700
gcggcgatga aatcttcacc atcagttcca catactttat tcagatattc attaatttta 26760
cgagcaatcc actgaatacc aacttgacca aaaattgtga tagcagtagc atttcgcaaa 26820
tcatagtaac ggaaatgaat attaccaaga gcaccataaa gactgttaat aagaatttta 26880
cggttcagct gatttgtgtt agcaagtgta gctgcttttt cacattcttc gatcagacta 26940
ttaagaacag attcagtgta attcgataat tcgtttaaga aatcatcatt gaacttaaca 27000
tatcgttcaa cttctggttt agttgaacaa gaccctgcac ctttcataat aatcttttta 27060
atagcttcgg cattcatttc ttcggcgaac attttctttt tccaatcttt acgctggaaa 27120
aatactttag cgatttcctt tggaatgata ccttcttggt gcttatcata catccatcca 27180
ttcggagagc aagaatattc atcacttggc ttaggagctg ttcctgcgat atattcatga 27240
attggatgaa ctttaaactg tccacgaata gtctcaggac taatgttaac ctgacgaata 27300
atgctaggat acagagacgt caagtcaaaa ctcataatgt atcgacgagc aatcggttta 27360
ggttcaaaca caaatgcacc tggaaaactt tgtttaacgt gcgaaccttg ttgaggaata 27420
accttatgtt cacctttcaa tgagttaaaa ataatagcat cccaagtttt aataggactc 27480
attacaccag aaaaaggcat tttagcataa taagacatac ttaaaactag atcgataaac 27540
ccacgaattt tatcaattgc ttgaactgat tctacgtcaa tgatgttata actaatgtat 27600
cgttgatgat tagtctcacg aagtttatta ataggaccat catatggtaa tttacctttt 27660
ttggtttcgt gctgagcaac tgattccaaa gagaatgatg gcaaattagt aaatgcgaat 27720
tttttgtaca aatctaaata atcaagaata gatacgccat caatagaata aatttctttg 27780
ctaccgtaca tattttgaat tagtttagat tttactcgac cgattggaga gaaacgtttc 27840
atactacgtt caccgagaac cattttaaca cgattcatga tatacggaac gtcaaatccc 27900
tcaatattcc aaccggtaaa aatagcaggt cgtttctgtt cccagagatt aatatattcc 27960
atgagcatat cacgctcatt atcaaatggc atataaatta ctcggtcaag aatttcttga 28020
ggaacttcat caccaccttc acagtcaagc ttagcagcta actttgcatc ccattttgat 28080
actgaaccgt acattgaatt caacaaatca aagacgtaaa aacggtcgtc aattgaatca 28140
taatgagtga tagcatcaat ttcatattct gctttcattg ggtcaggaaa tttatcacca 28200
gtaacctcaa tgtcacaatt agctacacga acaaattttc ggtcataaac aatttctgaa 28260
ccatatgtat cactgatata agcgagtttg aaatcgttca taccaagagc ttcgagaccg 28320
atgtcttcca ttcgcttcat ccagtctcgt gcatctttca ttgatggaaa tttttgagga 28380
gcgcaatttt taccataaat gtctttgtat tttgactctt ctttacaatg cctaaacata 28440
gtcggaagat attctacttc acgagtacgt tcctttccgt tttcatcaat ataacgctca 28500
acaatgttat ttccgactgt ttcgatagag atataaaatt ctttcataga tattccttag 28560
tttatagccc gagttattag gctcttgata tattatactc caaataaggg gccgaagccc 28620
cttgcttaat taccaatcgt atattttgga acgagtttcc attcgtgttt ttgcttaaaa 28680
gaaataactc ggaagttatt agttaaatct ttcataaaag ttctttgacc aggaacgatt 28740
tcaatcagcc cccaatcttc taacagccat gcaatcgaat cacgacgaac ttcatcttct 28800
tctgtcattt caacctggcg accatccata cgaagcattt ctttaaaatg aacgatatag 28860
tatagtcctt ttttctgaag aatgtggcag gactgatata gaactttatc tttattatta 28920
gcaattccca tacgagtcaa agtttcttta actttcagaa aatcttcagg ttttttaaga 28980
gtaatttcaa tcattttacc attccaatgc tagttttttg agttgtttct gttcttttac 29040
gttcttagtc acttctttca aaaaatcatc cgtgactaaa ccttttagtt cttttaatac 29100
taaaggaagt tttccatttt tagtaagaat tgatttatag ttaattgcat catttgtatt 29160
aacttgatac cgcttagcaa gtaacttaat aatcaatact tcggtagaat cttcgaccag 29220
ttttgcccat ttaccatatc ttttaccccg aggaacagca gccatcagat aattaaaatg 29280
ggcttcatcg cttaaacctg atccaattaa attcatagca tatacagctg gcatgcattc 29340
aggaaattgt gataatgcat tctcaaccat gtattttgaa taatcttttt gagcaataga 29400
gcatttagtt ttattattaa tagctccaat tatttcaaaa aactcatttt cagctttttc 29460
tttaaaagaa tcagcagcag attggacagc tgtccaatct tttgaatacc aagcaacttg 29520
atgctcgttt aattgaatat catcttcaaa taagctcata tcacttccac tgcatttcgc 29580
atgccaattg aatgaaaaga tatgctaaat gtaattccgt attagccgca attccatgat 29640
actggttatt ttcaccaaca atttcataca tacgaataat actttgcgga gttacgcgtg 29700
tataaatttc ttcggcaagt ttacctacga accacgaata atcagctgca tattttggtg 29760
ctaaagctct gagctgttta acatctttat ttttgagaga ttcaagaaca tcatcaatag 29820
caccacgatc gttagtaacc agtgataaaa taccagcatc caaaacacct ttagacgaat 29880
aactatcgag ctcaccaata gttttacgaa aatcaggaaa attcttttta accaaagctg 29940
ctacaacttt catatcagct atagcaattc cttcatgctt acagatttca gtcaatcgac 30000
gaatcatctg cttcatcatt tcaattttat cttcatcggt cggttgaccg aacgtaataa 30060
ctcggcagcg tgactgaagc ggtttaataa taccatcaat attgttagca gtaataataa 30120
tactacagtt tgaactataa gcttccataa aggaacgaag atgtcgctga gactctgcta 30180
accctgaacg gtcaaattca tcaataacga ttactttttg acgaccatca aatgaagctg 30240
cactagcaaa attagtcaaa ggaccgcgaa cgaaatcaat tttacaatct gacccattca 30300
caaacatcat atcagcattt acatcatgac acaatgcttt tgctacggtt gttttacctg 30360
ttcctggaga aggagaatga agaataatat gtggaatctt acctttactt gtaatagatt 30420
taaaggtttc tttatcaaag gcgggaagaa tacattcatc gatagtagat ggacgatatt 30480
tctgttcaag aatgtgttct ttttcattta cagtaatcat aatttcctca ttcaagtttt 30540
agtgtaaatt ataaagggcc gaagccctct attaaaaatc gtgggtagaa tcagcttcaa 30600
gagctactac ataattcgca tgttcacctt caaatttagc agcgccttgt ttaccttttg 30660
cccagagcag aagtttataa tttcctggtt gcattttcat atttgccata ttgataatga 30720
aattaaatgt attttcacca tcataatcac caagagtcaa agaatattta acacgagtca 30780
aagcagaatc ttctacttta ttaaaaccgt taattacgat tttaccttct tttactgtga 30840
tagcaattgt atcaatctgc agaccacgag atacacgcaa tagctgttga aggtcttcag 30900
ctttaatttc agtaacaaca gatgctactg ggaatggaat tggtttatta ggagcaacta 30960
ctgtactcgg atcggctgct ggccaaaaaa ttgttgaacg ggcatcagca attttaatat 31020
taccatcttc tgactgggaa atttctgcat cgtcattaac tagagacaga atacccagaa 31080
aaccgttcaa atcgtaaatt gctacatcaa aatcaatagt gtcagaaata tttgcttctg 31140
cataagttgt accattaact gcgcgagtca taataaattg accagattta agcataatac 31200
cagagttaat agtagcgaaa tttttgagca gagcagtagt atctttagac agtttcatgt 31260
aatttccttc aattcaaatg agatttaatt ttataactag tttaataaag caattaacga 31320
ttaaaatcag tagcaattgt ttccgcaaca atttgagcag caacaattag acgttcatct 31380
gcattaccgc aataatcatc ttcaaggcgt tcaccacatg aagtcataat aaatttagca 31440
ccagcattta gagattctgc cgtatgtttg cgcattagtt caatccattt atcactcact 31500
tcacgatcga tagcttcata atacgcatga cgagcaggtg cagatttaat tttattctga 31560
ataacttcca ttgcgttatc agaaagagac aaaacccatg ctcgacgaat tttattttgg 31620
ttttgtggat ttgaatcaga acgcacgtgt tttggctgaa tatcttttac atcaacagta 31680
taattcacag taattttagt cataatacac ctttagtcat aataatcagt aacagtccaa 31740
gcttcattcc tgttggacat tattttcgta tattctgatt taaatgcatt cttaagcata 31800
gattcagtaa ctatatgctc ttcattagaa aaattatttc tcagaatata tcgttttatt 31860
tcaggaacag ttaatagatg ctgtccagtt gaatattctg ccacagttcc tccgtataaa 31920
tatgtttatc actcgctgta tcaaaaggat atgttatgaa ttataaacta atttatgaaa 31980
agttaatctc taatgctaaa tctcgaaaac ttgattgcta tactgaatct catcacatta 32040
taccacgctg tttaaatggt agcgatgatg cttcaaactt agtagattta acaccagaag 32100
agcactatgt agctcatcaa cttttagtaa aaatttatcc ttctgaacca aaattagtct 32160
atgctgctaa catgatgaca gtttctacga aatacgctaa acgtaacaat aaaactttcg 32220
gctggattcg tcgtaaactc tgggaaatag aaaagaataa agagttctcc caagagacac 32280
gaaagaaaat gtccgatgca gtagctaata aagcaagact aacttgtcca cattgcggta 32340
agtctggatt aagcgggaat atgaatcgat ggcattttga taactgtcca aatcacccta 32400
atcctaaagt tagaccgcca atgtctaaag aacacagaaa taatatctca aacgggctta 32460
aagcaatcgt tcttgaagaa acatcctgcg aattctgcgg aatgataggc aagaaatgcg 32520
ttatcgcagc gcatagaaat ttctgcaaga aaaatccaaa tggacgcaag aaaattgaaa 32580
agactggtac ttgcgtccat tgtggtaaag ttaccacttt cggaaattta tcaagatggc 32640
ataatgataa ttgtaaatat aaacctagct aatcttagct aaactaaatc taccaacttt 32700
ttccatttga atgtgctgac catattcctg cgggtcatgg tctttatgcg aaattatgaa 32760
gaagttggta tccttcaaac catctaaaat tttagccaca tttttaatac cttcagcatc 32820
aaatgcaccg tcatacactt catcaagaaa taaacaactt attttaacac ctgaaacttt 32880
ttcagcaata tcacgccaag taaataaaag agcaatatca attcgtgctt tttcgccttg 32940
actaaatgaa gcataactaa aatcttcacg accacgggat ttaattgtct cattaaattc 33000
ttcatctaat gtaaacacat aatccgcttc cattatttta agataatggt taatctgctt 33060
attaaataat ggaatgtact ttttaataat agcaccttta ataccagaat ctttgagcat 33120
atcagtcaaa attcctctgt ggtatttttc cattactaaa ttagtttttg tcttaacaat 33180
tttatcaagt tcttcttgaa gcagtgctat ttcatcagca tggtcaataa actcagatga 33240
tgctttttct atagctgctt taactttttt agctttatct acagtcgtga ttaaggattg 33300
ctttttattg cgaatatcat ttgccagcgt ctgctgggtt ttaatattat ctcggtattc 33360
atcaacaaga acttttaaat tatcgcgatg cgttgaaagc tgttcaaacg aatgtgtgca 33420
ttcagaaact ttatctttaa ttttagaaac aactttatca ccggaactta attgtgacaa 33480
acaggttgga cataatccac cttcgtgata catattaatg actttattat acgagtcaat 33540
ttttgattta attaaaaatg cttcttgacc gattttatta aatgcatcag tcgggtcttc 33600
atccaaaaca atattaacta atctttcatt agcttcttct atttccgatt ttagcgttct 33660
agcttctttt gccaaatcat cgtacatatt ctgcagacga gtaaggttat caccagttaa 33720
ttttttctgg cgttcaacgt tatcattata tattttaatt tgttggataa tactatcttt 33780
tttaacatca agcacttggt tttgtgaatt taattcacgt attagtgctt tattaagctt 33840
atccatttca gctaatgttc ctacctcgag caggtcttcg acgagttttc ttcttgcagg 33900
agtggatagg cccataaaag gggtatatcc agccgtgccg agtacgacga tctgtttgaa 33960
actggcgtat gacattccga taagctgttc aaattctgct tggaaatctt tactgctggc 34020
agattcatta agacgtgtac cgttaacggt gatttcgaaa acgttcggtt tttgtcctct 34080
tttgatatag tactttttct catcatattc catccacagt tcaactaaaa gttctttctt 34140
atttgtgctg tttattaatt gacctttctt tacatcacgg aatggcttgc caaaaagccc 34200
aaatgtgatg gcttctaaca tagtagactt accaccgcca tttcgtccag taataagagt 34260
tttttgaacc ttatctaatt gaatgtcaac tccattttga ccaactgaca ttatattttt 34320
atattttact ctattaagtt taaatgattt cattttgtat ccaattgttc acaatgaaga 34380
aaattcttta actaaagcct gtaatgaagc ctctattgga tatccattct taactaacat 34440
tttcctaaac attacatgtt taggacgatt atatgatatc cacaattcat acaatttatc 34500
tttattatcc caatgatagc cttttcgtcg agatgctata tgagcttttc taatctccgg 34560
atttttccaa ctagcagcta ctgaatttga tatagctatt ttatattcag gttttgataa 34620
agcagcacga acagcctttt ggtgtttaat tttattttct tcgttattaa accattccct 34680
tgaagccatt gaaatttttt gttttgtttt aaaattattt aatctttctt tgttatcttt 34740
cctatttttt gctactgaga aatattttaa tgctctttct ctagcagcat ttctattttg 34800
cggatttgaa taatactgtt gaagcctttt tgatattgtg tcacttacat cttgttttat 34860
aaaactatat tcagcagcta ttaaatcaac ttcagctaaa gataaatttt tatatgtttt 34920
tcctgacatc attctattta aagcatttag catttttcca tttttacctt ttgctaataa 34980
gaaatgggct ttaaaatgat taaaatgact taaattaact aaattccatg tagattttaa 35040
atattcagga aatattgatt taggaagcac gtggtgtgct tccgttttac ctggagtttt 35100
aacagttgaa ttcatagaaa taaaattaat gtaagacttg gcgtcttctt cactcaacgc 35160
taatttttca actaattcct ttattaaaaa ttcatcatta atgtcaagtt taaaattctt 35220
cacaaaagat tccttttaat gtatctttta gaccattcta tcatatcatc ataatctaaa 35280
aagtattcat caaattcaac catgcaaaca acgccttgtg ctgcttttga tgtgatataa 35340
attattccaa catatctaga atcttcttcg gtgtaatcaa tatttgctat aaattcatcg 35400
ttaatgtcaa atgtcgaaaa cttcacagta tgcatcctta atgcaagata cagccatatc 35460
ttgtaatgat ttaggtgtgt cattatctaa aatgttgaag ttaaaagata cagcccagtc 35520
agtgcagacc gtgacctttt taatacaatt atcttcaacc tctagcggtt caaaccagta 35580
ttcaataatt tctttatgcc caatatcatc ttttacttcg cattcaaaat gctgacacat 35640
cataacattt ttaaattcat caaaagtcat tgtgttgcct ctacatataa ctgatttgca 35700
tattgaataa gtgcttcgcg atcagaatca gtgatgtctg gaattgcatt aatgtattct 35760
tccatcaacg tctgaagaga ttgaacttca acttcttcat tatcatctga ctcgacagag 35820
ttatcaatct ttgacacaac tcgtaatgaa tgcacaactt tttctagttc agattcgaac 35880
tttgtcagat ttttgtctac ctcagttact ataacacgca ctgacagatt tgtaaaatct 35940
ttatagtcaa tttttccctt aaatggatat tgaattcgac gatgccaggt agtgttattt 36000
ggaataaatt ccattcgttc tgtttctgta tcaaacatcc agaacccgcg agggtcattc 36060
tcgtcacctg cagttagtgt ccatggtgtc ccaatatatc tgacgttagc agcctcagag 36120
atagtatgga agtgaccaga ccacacttct ttataagtct taaggaaatc aggttcaaga 36180
ccgtgagatt tcattccttt ataaaaataa aatccattca gttcccagtg accgacacaa 36240
aaagaagcag atgaagtttt gatgtgttca agaatttcac cggtattttc ttcacacatc 36300
caaggaatta aatcaatcaa acatccgtca aaatctactg tagtaggctt atcatatact 36360
ttaacattag gatatttagc caaaagctca gtagaagcgt ttggagttaa agtattttta 36420
aagtgcatat catggtttcc tacaacagta tgtagggtaa taccagcatc atcaagcatt 36480
tgaactattt cacgtgcgaa ctccatagtt ttatgcgtga ttgcttttcg cacatcaaaa 36540
atatcaccgt attgaatcca tgtagtaatt ccatttttct tagaatattc tatcgcctgc 36600
ttaattccat ccaactggat tgattgaacc cactcatcat cagctttaac gcctaaatgc 36660
caatcaccta aatttaaaat tttcatatat caagaaccgt cattgaaatg caaaataaaa 36720
ttattgaaat aaatccatct ggagtgctaa agaacccaat ccaacatgct ctagtgaata 36780
gataaaatgc aagaaaaagt atcacatatc caagaaatat cattatatca aactccgtat 36840
aaagctaaag ggccgaagcc ctttattttg taataatgtc aaactgctct ttaaagcaga 36900
agcttgaatc ttgatgctga tacaaaaatt cataagcttt ttcacgttcg cggtcataaa 36960
gagctcggtc agatgacagt tctttaatac gctcaaatgt tgattccatg tcattttcat 37020
caaaccaaac gataccgcta tcatgagaaa ttaacggagt attatcaaca cggaatttta 37080
aattttcgcc agtagatttc caaaatactg gaattgttcc acatgcacca agctcgagat 37140
gagtgtattc taaagaacgt tgtagatatt ttttatctaa tttactcagc tgataaccaa 37200
atccggattt actcatgcgt tcaagcattt cgctatttac ataacggtcg agaatttgcg 37260
ttggcaaatt aggagcaatt ttaatttggt ctacttgatg aagacgataa tactcgtatg 37320
gaattccttt ttctttaata ggaatgaacg ctggagaacg ttccagacct tccataatag 37380
tactcaatcc tgcaggttta agatgttttt catgaaaatc aaacatctga taaaagcctt 37440
tccatgtagt agtacgacca atccaacggt tgatattcat gttaatttca gaaacatctt 37500
tccagtaggt tgatcgaacc ttcgcaatat ccataggagg ctgaaagtta tatacggtcg 37560
gtgcttcttc aatatcatca aacagagaaa ctgtttctgg ataccattct ttcatcaaaa 37620
ctttattaaa gtcaccatta tcagaatggc taaaaataac atcagctcga cgaacagttt 37680
cttctaatcc caaatttcga cgcaaagaaa gagaagaatg gtcatgttga taaactacaa 37740
cacgaaccga aggtttaatg ttatcaataa tttttttata gttattaata gtgtcttctt 37800
cgactgaagt agcaggaact gaattgataa ttagaatatc acaatcattt actagcttaa 37860
gtgttttatc gtattctttt gccaataaaa ccggaattga aaatgattta taatcatgcg 37920
cgcaattacg ggtaaatgat ttatctttag cataaaccaa agttacttca tgaccatttt 37980
taataaacca atcacgctgc tcaagagaaa atttagttac accacaacct tcaagacctc 38040
gagccataaa aatgcatact ttcatttaat atcctcattg ttttggttta ttttaccaaa 38100
aatttataaa gcaatatagg agccgaagct cctatccgca taatacacca tacagaggct 38160
cattagagct tctaaatttt atacgtttat gtgttatagt tccttctgct ttagctttat 38220
catgagactc tttaaagcgt ctcatcattt ctactttaga ggaacgaatt ttattataat 38280
ctatttcaca agtctgggcg ttcatctttc acagctgcca ccattttttg acttgataag 38340
aatcaaccca cactttcata ttagggtctg ctcttacaat aggaggatta acttctttaa 38400
ttgaactatc atggtattct ttttcagaaa ttttcacgca aagatgacca ttcaaagatt 38460
cagtaaatcc tgcattaatt ttaagacgct tgaattttac gtgtgtaagc atcaatcata 38520
tcctcaatct gcgatctagt agtcttccaa agaatactaa taagttcatc gttatatggc 38580
tgttttagaa tatcccgact tttcttgata gcatattcgt attgagcaaa attattgttt 38640
tcagctgcaa tctgagcgtg cttgtaaaga cggttcagtt cgcgtttgtt tttagacaat 38700
aacttatttg cttttctttc tgcttcaaga cagttctttt cttcaagaga agaaataagc 38760
ttttccactt catcattaat ttcgggttta tcagtcatat tatttctcta atataaaata 38820
aaaatcatca tctgttaaat gataccgata gtttaattct acaccgttag atttaaaagc 38880
ggtatcatac ggattttctg gatcaatatc aatgtcaaga gctaaaactt ccctgagata 38940
cattttaagt aaatagggaa tagcttcaac ttcaggtatt tcttccaaga atccggagag 39000
gttaatcgtt agcctcatat aaaaaatcca aactaggaga atcgtctaca acacttttct 39060
tttcagcccc cggtgttcta taggttgatt cttcgtaatg cgtcatttta tcgtagatgt 39120
cttgaataaa agtttcatct actaacgcaa ccatatcgtc gtcacgactg tcatagacat 39180
tgtgaacgaa gtaactatat ttctttgcaa cttccttacg ttctttttta atacgttgga 39240
cgaatgcatt aaaacaagct tgagttatat atgcatgcgg gtttttatat ttcgtttcat 39300
caaaattatg aagcccctta atagaagctt ctataccatc tgcaatcatt tcttgtttcc 39360
aagactgggt gtatcctgaa aagttgaaac gtttagataa gccttctgca ataagcataa 39420
tggctaatcc gatagtatca ttctgacgaa ctactttatt tgggtcttta ttatttgcta 39480
attctgtttt ccaatcaata atagcttgta aaagctcttt attgtttacg taattatatt 39540
taggcttagt ttctgacatt ttcacctctt agctcaattc atagatctat tatatcataa 39600
tatttgaaga tctatcttaa agcatagagg atatcagtta tctaagtaag cagtatgctt 39660
ggaacacttt ttccatcatc tttttaaatt catgaatatc tatataatga ctagttaaat 39720
cagcatgata taaaaagtct aaaaactttt catgtgtgct agcatattcg ctttcattta 39780
attcagaaac atgactttcc caatatccaa caccagtctt atttgggaaa aatgaaattt 39840
tcatatattg gtcaacatag aaaattccat aattttcaat agtaatagaa atattaataa 39900
atttcataca ttcatcaact tagccgcttc aagagctgca tctagtgaat caaattgatc 39960
gacatattca atcagtttgc cgtaattagc atataaccac cattggctaa attcatactc 40020
aaggataaat ccatttcctt caatttgagt taaaccactg ccgtttgtat ttacttcata 40080
tccggcaaga cgcaaatcat tgataagaga ttcattcata attatgcctt agtaattttc 40140
aggtcagcaa attttttctt gcgttgattt ttcatacgac gaatagtttt atcagaaatt 40200
tcgtgctttt gataagcttt agattctaca ccaaaagctt taacatcaaa ttctgacaag 40260
atatattgaa ccaacaattc acggacagta ttgcgcccaa ttttctgatc attctgtttc 40320
atcgtctgat gaagctcttt ttcccattta tccaaaattt gaggagttac aatatcgcct 40380
ttttctagca aagaaactac tttatcatat gcgtaagaat tgatggcgtt tttaatttga 40440
atagtcatac attatcctca attgcattaa aattttatta tccaaaaagg gccgaagccc 40500
ttagttaaac tgtttggcac ccttccagcc ttcgtacatc attgcagctg atattaatat 40560
tgctcctgcg cattttgaat atttgtgatt ccaaaaccag ttcagaaaaa cttcgtcatc 40620
aataccttgg gctatcatat tttcaaagaa ctgacgacga gcttcggcaa ttcgttgtga 40680
taatttagat tcaggattca tttaaatttt ccagttaccg ttttcatcaa taaatttaat 40740
ccagtcattt actgaccact tggtcgtatc gccttttgga gtaacattta aagtgtataa 40800
tccttgctta aaaagcattc gtttgatatt catattttcc tcagctgtaa cgatagcact 40860
cgtttgattt acgcttagca actcgttgag aagtattgta atcaaaatca tcgtcaatgt 40920
aaactgattt tttcaacttt cttacttcac cacgtaattg acgatttaac tcatctttaa 40980
cttctgaatc aatgcctttc attctacgcc atttatcaga gcgaaaaatg ttttcaacca 41040
tatctttatg acttacacca tcaggagctt tacgctttcc gaaatagtca taatcacgta 41100
cttttaaatc tttacgacga tacgttttac ccatggagtt taatttcctt agcaactgaa 41160
ctaaatacag cacgatcaca aatcatctgt ttatgtaact tgagtataag ataataaact 41220
tcaaaaccgt ttacataagt aacacgaaca acattaccat taataaaata atattgtccc 41280
tttttaattt ctttatcaac cacaaccata tcaaatcctc aaaggcaatt catatgttaa 41340
taataccaca gtttgaactt cttgtaaaca actttgtgaa attattttag ggaatgataa 41400
gaagggaacg atagcttaga atggtaatat acagaatgcg agaaagaaag gcccagaggg 41460
cccatcttaa tcttctatga tatctctatc atatccaagt gaaatgagag tttctttgaa 41520
gtgtttaatg ttcttttgtc tagaatcatt gatgaaaatg actggatacc gaatgttaag 41580
agatgtgaat ccagcgcgtt tagcaagaga tacaatcagt ggacgatcat actcaatctt 41640
accgttattt gtaagaactt tatagaaagt aaaaggagca ttgagctcct ttaaaagttt 41700
tgtaactgat tgacatccag gacaacgacc tacttcatct ggaattccat agacttcaat 41760
cttgttttgt ttcacaacta ttccttacta agagcagcat tcagcttatt agtaatttta 41820
tccagacgct cattgaattc gctagaagac agtccttttt ctggagaaat caaactaatc 41880
acgaaaaata tagcaataaa aggaataaga aaaatagctc caactgccat aaacaaaaag 41940
aatgttacgg ttgtaagaaa atcagctaaa cctttacgaa atttatacat attttaccct 42000
taattgatta accaagcatt gataagcact aaactatatt gcgaataaaa ttctggacca 42060
aaatgaaaaa ccatatcatt tatagtgtcc ataatataat tcaatttaat catgtttcca 42120
caccccatcg gtatttgacc aaagtcgctg attatctgat cctcgccaca gctttttagt 42180
cggaagattt ttctcatact tcccatcaat aataacatca acatatttaa gcatttctag 42240
ttgtttaata tcttcaaact tatatcctgt ccacaaccaa atgcttttat ttggataaag 42300
attttttact gtttgaacta cagagtgaat aacatctcgg ttatcaggat agagagggtc 42360
tcctccagtt atagttaatc cttctatata atcattattc aaacattcaa ttaattgttc 42420
tagtgtttca ccagtgaatg gaacgccatt tctagcattc catgttgatt tattataaca 42480
cccttcacat ttatgcaaac accccgtaac gaaaagaacg accctgcatc cagggccatt 42540
cacaaaatca caaggataaa atctatcata attcataata atatccaatt tttccaagct 42600
tcatcagtag aattacagcg ttttagtata agatgtctag aaacttttat ggcatttgag 42660
cactttttaa ttgaatcata tttaataccg tcaactgaaa cggttttgct agttggagaa 42720
atttttccat acattggatt ttttgaacca acttgaagtc cttttaaagc ttttgaaagc 42780
ttttgtctag attccaatga catgggagaa ttctttttac cttcaataat tcgcttgcga 42840
tgaagttcgc gttcttcttc gctcaaagaa ttgtaatatt ttttaacacc gtttgatata 42900
gataatttat ctttctcaga ccgctctcca actaatttac ttctaacatc ttttcgcttc 42960
atagctatgc ttacagcttt atttaaattt gcttgatgct ctggcgtacg tttatatttc 43020
tttaaagcac gtgaaatagc tattttagtt tctactgttt tctttttacc tttatttgct 43080
aaactatttt tgtggcgatg ttcaagtgtc tgttcataag cagttccacc ttttccaccg 43140
ggtttaatat tatatgtatt ttcttttaga caatactctt cggttacaag ttcagcttct 43200
ttatcataca tttgtttttc attatcaaaa acatgtaaaa tttctttatt aaaatttttt 43260
ctaccatatt ttaataaagc ggcacgaatc aatgttcctg atcccatata accgtcattt 43320
atgttatcgg tgctatgcgc accgatatat tcctttgaat taattatatt tgttatttta 43380
taaattatat aatacctatg catgttttac tcgttttacc atttctttca ttttacctaa 43440
attccatgga acaacgctag gagttccaag atatccgcat gttcttctta ttgtattcat 43500
ctttttagga tcagtttctc cacaaataga acaaacaaat ccgttttcag taggagtcat 43560
ttcatgggta cttccacatg taaaacattt atctactggc atattaacac caaaataatc 43620
taaatgttgt gcagcataat cccatacagc ctcaagacct tttaggttat ttttcatatc 43680
aggaagttca acataagaaa tgtgaccgcc tgttgcaatg aaatgatacg gtgcttcgcg 43740
agaaatcttt tcaaatggag tgatattttc ttctactgaa acatggaaac tgttagtgta 43800
ccagccttta tcagtaacat cctttacact tccatatttt tcagtatcaa gtttacagaa 43860
gcgataacaa aggttttcag caggagtcga atataaacta aaagcaaaac cggttctttc 43920
agtccactgc ttaagacgag cattcatttt agttaaaatt tcctgtccaa tatcacgacc 43980
gacaagaata ttcaattcgt gaataccaat gtatcccaaa gacactgaac ttctaccgtt 44040
tttaaataac tcaattatgt cgtcatcagg tttaagacga accccgaatg caccttcttg 44100
gtaaagaata ggagcaacag tagctttaac tccttttaag gaactgattc tacacatcaa 44160
tgcttcaaaa cataaatcca ttcgctcatt gaataattca gtaaatttct gttcattgaa 44220
ctgtgttcca atataagaat ctaatgcaat acgaggaaga ttcagcgtta caacgccaag 44280
attattacgt ccatcaagaa tttcattacc agtcgaatct ttccatacgc ccaagaaact 44340
acgacaaccc attggagaaa caggaataga tgaaccggtg atagctttat tgttcttagc 44400
cgaaatgatg tcaggataca ttcttttgct tgcgcactct agagcaagct gcttaatatc 44460
atagttcgga tcgtctttat aaagattaac accctcttca acgaacataa caagtttagg 44520
gaaaatagga gttatcccgt cacgaccaag acctttaata cgatttttca gaattgcttt 44580
ctgaatcatt cgttcagtcc agtcagttcc cgtgccaaat gtaattgtta caaaaggcgt 44640
ttgtccgttt gaactaaaga gagtatttac ttcatattca taagcttgga atgcatcgta 44700
tacgtctttt tctgttttag attgggcata attcaatgca tcagcgattt gccatttttc 44760
tgcatcctca atatgttttg cataggtgcg tttaacatat ggagaaagta ctttatctac 44820
attcgcaaaa gttgttccgc catattgatg agaagcaacc tgtgcggtaa tttgtgccat 44880
aattgcagta gcaacgccga ttgatttagg agtttcaatc tgtgcattac tgagcttaaa 44940
tccgttctca agcattcctt ttaaatctac taaacagcaa ttagtaaaag gcaatgatat 45000
actgtaatct aaatcatgaa aatgaattaa tccaacatta tgggcatcta caatatgact 45060
tggaagaata tgacaagcga tatgtttaga aacaataccg gccattaaat ctctttttgt 45120
tggaaagacg cgagaatctt tgttggcgtt ttctgtattt aattctttat ctttatttga 45180
aataaaattt aaaacatctt tttctaaaga cataattcta atttatcctt ttgaaattct 45240
tcgtctaaat atgggttcca acccatttta aaccttttga tgaaattatc aattctaaat 45300
ttcggtaagt ttaaatccgc aaaaatagat gatttacttt taaaatctgg acttaaataa 45360
tcatataaaa tttctgcgta ttttaaccat aatatacaag taccagattt aattgctctc 45420
ggagttttcc aaggttttac accatacatc ggatttccac ttcctttatg cctgatagaa 45480
gatgaaattc caattttaat tttagcttcc tttgtatgcg aaaatccacg atgtggattt 45540
tctttccagt attttttaga agcttctgat attttctttc tggctaaatt agtatgatgc 45600
tttccataaa atccatgatt tttgccttta ttacgatttc ttttaatcat ggttattgat 45660
tgcttttctc tagtttcttt agaaggagaa ataccatatg tcgtaaattg gccatcagca 45720
tatgctaaat taaaatactc tttattccat acatcttttt ctatattctt ttgaaattca 45780
gcttcaatgc tagttatttg ttcatctccg actaattgaa aatataatat ctcaactttc 45840
ggcgtttctt tcaataaggc tttttgaaat tcggaagatg acgaagacga ataataaaat 45900
ttaccatttt tatcaataat attcgttccg tcaaaagtgc aattggtttt acttccaatg 45960
taataatatg gcggggtttt agcattaatt ctactaataa acgatagttt atatactaca 46020
ttcattttaa actctttcta agctgcttct taaatgaaga tattaattgt gttttagtgt 46080
cagattcatt atattcaaat cctctttgaa gcatctcagc catcatttcc tcttttccta 46140
aacgagaaaa ttcctttgat ttatctccaa caaagttagg gtgaatatta ttttgggtgt 46200
aatctgattt taaataagta agtaaatttt ctaaccattc aagataatca acaccttgcc 46260
cctttaagcc agaacgatta aatttgtgtt tcatttgacc ttctgccgca ttgcagagat 46320
tacatagcaa cccacgtacc tttccagctt tcggtccatt taattcatgg tcatggtcaa 46380
ggtgattagc ttgaacatca ggatttaatt ctcgttggca aattaagcat ttaccgtttt 46440
gtgcatcata aaatttctgt ttttcttctt tatataattt gccagtcaat aacataataa 46500
acccttacct taaatagata agggtattta ttattttcaa gtattgtaaa acattcgatg 46560
caatcgctta tattgtcgaa tcatcttttt agtaggacga gaataagttc ctacacaagt 46620
ggtcatatta aggtctgtag aatttccttt aataaaaagt ttccaaacct taccaccatt 46680
taacttttca gtataaatca attcagtttt cattaaaacg ctcggtcaga aaaagaaatt 46740
tgagtttcaa gccattcaat atattctgcc gcggcttgca ttaaatttcc ttcataatca 46800
tcaatatctt ttttcaatgc cgatttagat aatgcgtatg aaatgcgttc accctgaaat 46860
ccagctttag gtttatgaag aacttgatca gttcgttcta caacttcttc aatttcgcca 46920
ttttctgcgg attcagtatt ccacaagcac caatacgtaa ttggcttatc atagatgtta 46980
ataatctttc catcagaaag ttcaatttca ataattccag tatcaggttc tatgtcatct 47040
tcacattctt ttgcaagttc acgaacttta aagacagtac ctgcactaag ttccggccag 47100
taattacaca gccctttatc agcacgatta attctaaacc acttatctac tgtaatcatg 47160
tcccatctcc atatcaatta tgtcatttat tgtaggttca ttatatactg tttcttcatc 47220
agtgtaaacc ggttcttccg gctctggctc tactgtttcc catctagccg cccaccaagg 47280
ttttatagcg taatccattc tcgtattgtc tgagttacta cacgttcacg gggctcaact 47340
agttcaacag tcggaactgc ataataccag tcagaatggt aagaacctga gcgagattca 47400
tttacagaca catgaacgtt atgttttgga ctaaaataaa cgcactgccg atattggcat 47460
ttgccatctt gtacccaatc ttctatttcg acaggtttaa gataatccga aaaatcgaaa 47520
tcataatttt ctgaaaatgc atcatggtct tcgatgattt cactcagaac tgcatcaaca 47580
tctaatttat tttcaatatt catttttcac cgcttaattt cgcaatttat taagttcttc 47640
ataatcaatc caggattcta gtcctgatgg caaatcagat tcaatttccc aaagaagctc 47700
ttcaattttc tgaagacgat ctaattcttc agctggaata gtaaccattg acggagttct 47760
tgatacacta atatcgtaaa tcatatttac cccagtttga ccatacaatc gccatatttc 47820
catttagaaa tagacttttc accgttagaa taataaactt cgagtttagc acgattattt 47880
ttaatttgaa taacctttgc tgtcatcaaa gttccatacc cgtaataaac tgcaacctca 47940
tcacctacat ataccgcgct tccgcggtag tcatggatat aatcagttcc ttctagcgtc 48000
atttaaagta ttcccgcaat tggtcaaatc caccaatatg acttccatca ggagcaaata 48060
cttgcggcat cgtcagtcca atttgagtat cacgacccag tttagttaga agctcagcga 48120
ttttctcatc atcaaaaaca cctttttccg gcataatatt gataaattca aacggctgtt 48180
tcttcacagt caaaagacgt tttgcattat cgcaatacac acatttatgg atgctgctat 48240
cataaccata tactttaaac atattattcc ttaattccta gtacttgttt aaaagtctcg 48300
tcgtaatcaa gactttgacc tgtttgttct ttatgtttgt atataatatc acttacttct 48360
gatagcatat ttttatatga acgagttaaa gcagatttaa gcacgctata tctatcagga 48420
aatttaccgt gttcattata atacgctatt gctaattcac ggactgcctt ttcagcagtc 48480
tccatatatt ctttacgctt tgtcattttc ttctcggtta aatcggtgtt tgcaatgacg 48540
gcatttatag cgaagattac tagtctgcca atggactaat tgaacctgtt cagtaccaca 48600
ttttgggcag ttcggaacat tcttagaagc cctttcgcgg cgttcaacca taaccataat 48660
ggcatcccaa gcaggaggtt taaagtctag atcgtcacaa ccatgaatct ttccgcgcat 48720
ttctagatcg tcttcttcac cagccataat aattttaatt agactggaat tacttgaagc 48780
tgcaatatct tctaataaac gctttttcat ttcaatacct caatagcatt acgtaaacca 48840
tttgcttttg cattaagaga ttttaacaat ttggtgtgtt cggcaatctg ggcttcaact 48900
tcaatcaaac gagcattgag atattcacgt tcttcgctca ggttatcaac cttttctact 48960
ttaggctctt ttacaactgt cttatatgta ttagggttct tcagtttgat tagaatgcgt 49020
gaactgtata acattgaacc attatcttcg atttcgtcat acatttccac tacgtccata 49080
attttagcat catgcggagt ttataagaca acgaacgaat agttttgttg tgcttattaa 49140
tttctctaga gttcatggtg ccgagattac gtgagtaata ataaggaacc tggatattaa 49200
ttaatactga tgaaccaccc ggcttgtgtg ttacttcatc agcaataacc cagtccttaa 49260
catgaactgt atttgtacgg tcatcgcccg cggtaaatag tttacgagca tgcttaaaaa 49320
gcatattcac ttggtcattg aattgacaag cgaatttatc agcaaattta gtttcaggaa 49380
tggtagataa ccaatcagcc aaatgggtct ttttaacatc gttaacaata gtaaattcaa 49440
ccaaatcggt tatagatgtc gcagatttaa tgaagctcgg cttcataaag tttttaatgt 49500
tatcattagc tacagtagaa gataacagac gagaacgttt aaaccattga agcaaattgc 49560
ctaatgaatg agaataggcg ttctgtgtat ctttacagat atgattttcc tggccaacat 49620
attgaaggaa atcacgaaga atattattga ttactgctct atgtcctatc tgataattac 49680
gatgtttagt aataagactg tcaaaataat caatataatg tttacgagtt ttcatgttct 49740
tctcacttgg ttaatgattt atgctccgag ccatccttgg ctttaaatta cttaattaac 49800
tgtaaagctt gttccaaacg atcaagacga ttaacagatt cttcccaaat ccttttagcc 49860
ttctcatatt ctttctgcgc tttattagaa atttctagaa cttctttata agctttttct 49920
agtgcaataa cttctggacg aatttctact ggttcaggcg aatcatcaag attatccatt 49980
agttcctcaa gggtagtttc ttctttaggg gtattcacaa tttcctcgca tttttgttgg 50040
taaatttctt tatcagtcgg tgaataagca catttcactt cacgaagact aactacaatt 50100
ttgtatcctt cccaaccgca tatattctta aaaggatacg tatgaatatt ttctactgtt 50160
tccatacaaa gtaatgcggt ttctaattga cgagttatag tgctagcaat tgagaaaaat 50220
ttattaatat tcctttggtt agtttctggt gtaaaaaatc cataattcac aaaaatagat 50280
actttatttt tatcaagttc atattctttt acgataatca tatcagaagc caaaggatga 50340
atttgacgat aatcgccata acataattta gaagctgatt ttaaaatttg ctttttgaaa 50400
agcctgaaat tactaatcca acgacgagta aaaatattct cagggtcttc tttattatta 50460
agatgataag aattaacatc accgaaccaa ttatatccta ctacatcttt ggttcgttta 50520
atttctttcc caaaattacc aagaatatcc cgattaacca aatatgaaag aagacgagac 50580
tctttaaagg ttttcttgat aacatcttta tctacacggc tagaaatttt acgaatttca 50640
tgaataaatt taacagaaga aacaagactt gcgtcaacac tattgagcca ttgattgata 50700
atagaaataa cgctattttg gccaaacaac ggtatagctt tatcatcaat aacgctattg 50760
aatgatttga tatattcgtt acgagtcata ttaatctcct cagtagaaag taagaacatt 50820
ataccacatc cttgtggcaa agtaaactag tttagtgcat ttagtgcatt gttcagttta 50880
gaacgttgct tcgtgagatt tttaactttt tcttgagctt tttctagcat cttttcagct 50940
tctagcactt cattagttgc tttaacgagt tcatcatcta ctgccttgat agacttctca 51000
atcgcatctg catgccattt ttcaacaggt ttaagactcg gattttcaac aggaagaaaa 51060
ttcactttat tgaatttcca tgcatcttta ttacctgaac tatacatcca aaatttagga 51120
tcgtttgatg agtaattgga taaatttaaa tttaagttat cttgcacttc ctgctttttc 51180
tcttgcgtga cttcgtcctt tctcaaaaaa tcgtatttaa atgaaacgat catatcaagt 51240
tcatacgttg ttgtatgttc ccaatttcgc tcaaaacgag gtaaaatctt agactgaaca 51300
gcggcaacaa catccatata cttaaatgct tctgtcaact gcgatttaag gcattcgcaa 51360
attgaaagag aattttttgt attaggttta aagctaattc gtgcagttct gttattttct 51420
tttaatggtc ttacttccat ctgaagagta taaccatcaa atttcaggtt ctttaagtta 51480
atgtcagaac cttttaatcg actcgcagtt gataaaattt tctttaattg tctacggaac 51540
agagcaataa atctccattc aatacgataa tgatttggat tgaaaaatcc agatgataaa 51600
tcgaccttac tttgaccaac gccttgaaca aataaaggat ttttataatc aatagtttta 51660
cagaaatcgg tgagctgctc acgagccgtc atttgtgtaa tataccccgc tttactaaaa 51720
tgacataacc attcactgct attcatatat ttaaagtgaa tatcacgatt aactttatca 51780
gggtctaaat tattttggca caaaaatgtc ataacatcac gagtatagct ggcattacga 51840
accatatctt caatttgaga acgagttttc atagtgttcc ttaagattta agtaaatcga 51900
caattttaat taacttttca cgctcagatt tagctttact actcaatcca gatagtctga 51960
aaatttcatc atcatattgt tgaatagaaa tattcagctc ttcaatctgc ttattaaaat 52020
aatcaatttg ttcagaatgt ttttcgttac tacgaactgg tacaggtttc gtaggcaatt 52080
tagttgaact ggattcattc gggcgataaa ttaaaataca acttgaacca atagggcatt 52140
ttgcaccaaa tgaatattct aatgttccag cttcttttaa aacttcaaaa gctaaacaga 52200
gatgatgccc catattaaca taatctgtag agtgagctct gatgtaataa tcatctccgc 52260
gaatactaaa tttaaagcat ttaaggtctt ctgtattatt ggtcttaaaa atcatttgtt 52320
tatctagacc tttagctaat cgagcgccta atgctaataa tcgtcgttga ttttcccaca 52380
aatctgcaat cattcgatca aatgataatt ttggcattag tcgaccataa aggtcatatc 52440
ctttattgta attacgaaga atttcactcg cattaatacg agacaacgct ccaattttat 52500
taagggcttt cataatgcga ttagataaac tcattccaga cccgtttgtt cgctgtagat 52560
gtttttctaa tccaaatcca atatcaactt taaacttatc taaaatttct gcatgaacat 52620
ctttgtcgat aacattcaaa tccaaagttg ggttaaatct atgaaaaaat ttatctggct 52680
ctccacgacg aaatacagtc cattcattca tcattttttt attaactaaa gatttaatta 52740
ctgcattgac attattaatt actactgaca tattttcctc actcaatttc aattttacta 52800
aatacacaga atatgattga acagactaca taagcgccac acacggattg aactaatacc 52860
atcccaaaga accaaacaat attatcaaac agtgtttgtt ttacgtcgaa aggacgtaaa 52920
cttacagtaa tattatcacc tttttctatt gaagaataca tctctgggga aatatattca 52980
ctaaatctat aaccgtcttt gagttcatat acggcaataa acgataaact agaccctttt 53040
ccttgtgttc ctgtaatggt attaactaca gtaacatcat aatctttata gtgcatataa 53100
tcattaattg cgtaataacc atatgcaact actacacata aacaacatat caataaattc 53160
aatcttttaa ttatcaactg tttcataata atctcaatta aaagggctta gaaccattat 53220
accatccttg gtataaagca gttatgcgag taccgtcttt aaccgttctt caaacttccg 53280
aagagtattt tggcgttcag ctctttgctt tttgtaagtt tcaatacgct ctgaaatgag 53340
agtgtatcgt tcatttactg attctttcat aaaatcagga atttcacgag aagctttaat 53400
ctcgtcaaat ttatcaataa cagcttgctc ttcagcaatt aagttatcat acattaaaat 53460
atctttcttg atgaactcaa tatcttcttg agttacacga gataatttag atgctttatc 53520
ctttttgtac tgttcgttag tatcacgaga ccaatgtaat gtacgatttt tattcgtatt 53580
cttgtaaatt tctacaatac cgatctcatc aataataacg atccaattcc aacgggattt 53640
gtaaatttgt cctccatcaa ctgtgatttc acctccgatt gagatgtcgt taaagaactt 53700
gctttgtgct tcagatttaa atttaccatc gttgtaattt accaagttga aaatatcttt 53760
agcgttcatt ttctgttcct ccgtagttga tagttgtata gtaccacaga ggaacagtct 53820
tgtaaaccac taaaagaaac ttctttcaca attttttcca ctgaaccacg cgctcactgc 53880
tttcttagtc tcaggagcag tgttatccat aaaccattca aaggcagcct ttttatgatt 53940
ctggagggct tctcgggctt taatctgctc acggtctatt aacactaaca tatgagcctt 54000
tcttgtcacc atgggcttct tatgattttt tgaatactcc cagtcatttg tccatcgcat 54060
tgtcgttgcg aactgaaata ctgcttcttt aattttagtt tcgtaaattt cacgagcctt 54120
tgagtataac atcactacct ccgtttacca gtttaattct agtcatcttt ttaatggcag 54180
tccatataat ctatttctga actgcctttt tgtcatagaa gtcctcttat gaattatttc 54240
agaagagtaa cctcagcaat ttcttcccaa ccgtttttgt cggtcataat aaagtcagca 54300
agataaagag cagtacgcag tgaaacattg cgtaaacgat taacattaac tttcatccat 54360
gataatgctt tataagtttc ttcatcagaa agaccgcgct tttgcatcat gtcagttgaa 54420
agaataacat cttcaaccct gaccataatt tcttcattag tgtgaacacc caaatccaaa 54480
taaaccgagc gggacactaa tgcttgtaaa tgtggagcaa gtttagtacc acggtctaat 54540
tcgcggtcaa tgtcaacgtt tgtgataaaa acaatcgttc ctttaaattc aaactcacgg 54600
tcaatgcctt tttcttctaa gtaagaagat gcagtgctcc agcagacttt acgggtctct 54660
ccggtgtcca gagcggcttt tagaagatta agaatgtcca tatcagagaa aacatccaca 54720
tcatcaatca aaaggacaga attctcttca cgattattcc aaagctgctc ataaagacca 54780
ataccagaga ttttaccatt aatgctttta tattcaatgt atccaatatc atttgcttta 54840
tttaaagctt tatctaaaga atacgtttta ccaatacctg ctgcgccaga gataattaat 54900
gaacgaatat ttccattaat aataccattc gtcatcattc ccataacatt aaatctttta 54960
ttaatgcggg ttttcatatc ttcatatgat tctttaactt cttcaacttt tacaccatca 55020
tatgaaatat ctgatttgta aacccaaaca ccgcgacgtt taccgtcaat ttcaacaaaa 55080
actttaccat ctccttgtgc atctaccgga gcattatctg ggaaccattc gcctaagagc 55140
tcaaaagttc cagagatttc tttaccgaag tagataccct tattgatagt tacagttttc 55200
attttattct ccaaatccgt atcagttgat agttgtatag taccataaag ctttatgcct 55260
gtaaaccgtt ttgtgaaaaa tttttgaaat aaaaaaggga gcccgaaggc tccctatcat 55320
ttataataac ttcgatggtt ttcgagatac accctctcaa ggaagtcatc ccagaaaccc 55380
atgtctactt tttgctgcat accgttctta gaagcttcaa tggatgctgc ttctacttga 55440
tcgaccacat cttccaaaaa ctcttgaacc gttttaaatg gatgtttacc caacttcacg 55500
tcgagaataa atggagcatc ttggagtgga taaaccaagt caccagtttt gtaaatttcc 55560
aatagttgga gtccaccacg gcaagcatga ctcagagctt tccagtcaat gccctcattc 55620
gcttcagcct tacgagcacg ttcgccgtat tcagcatcta atttgttcag tgactgctta 55680
agctcaataa gagaaagtgt tgtctgatat ttacgaccca acacagtgta aaacgtttgt 55740
ggacctgttt tctcatgatt atggaatacc cattcgcaga actcgttttc tggaagacga 55800
tgcttaatat cttcaacttt agtgcgacgt tgcttaatgg aaccgtcttc ttggtaatca 55860
acccattgct cagggatttg attaactact ttcaatacat cacgcaatgc agccaagcga 55920
gaacccttga caccgtattt agaagcttgc ttgcggacat atcctaaata ggatttcatg 55980
ttagtcgtat aaaaacgaga acgattgtct tgaataaact tccatacatc aggcaaatca 56040
gatttaacca ctaattcagg cggagtgtgg agcatatcca atgctacagt ttcaccatct 56100
gctgctaatt taaagaaata cttaagactg tatagttcat ggtcaatatc atctttagtg 56160
tttttagatg atgtgttgtt agtattttta ctcatatgct ctttaacatt tccgataaga 56220
atatcgcgag caggaggaac aaagatttct ttaaaatcta catcagattc tggagtagaa 56280
gttccataaa gatgactacc aaaatagctt ttcattactg ttttcatcat tcagccttat 56340
attcaataac aggacatact ttagctttac gcgcttttaa aaattcgact ataatagatt 56400
tcttgggttg aataggaggt aaccctttat acgccctatc aatattttct acatgtaaag 56460
cataatcctt tttccattta taatctttat atttttcatg cagttgtgca ggaataacaa 56520
atgaaccaat aataagtaaa acaagcaaaa tggcaagtat aaatgctgat ggaataagag 56580
tccataaact accaaaaata agccatttct gcatgatttc tgcgcagatg atagttagac 56640
ctgcgagtat agtacatccg aaaaaagaaa cgaaaaatgt aggaatgaca atagaccaaa 56700
aatacgcgca tagtgtctta ggtcgtttcc attcatcatt aaacattttg aataatttat 56760
agtgccaaga gctttcatta ataatcataa ttatcctttc attgaaggtg taacagttgt 56820
taaatactta atcatagcct cagcttctga ttttgataat gaaatttctc cattgttttg 56880
acgaatagaa ataaaatccg gatgacggtc accaccagct tttaaaacac acatataagt 56940
atcagtttca tcttcaatat ctgaaatgat tgaagcagtt ccacatgaat gtggtttttg 57000
ataaatcaat gcagcttttc ttccaccgtt tgactgttca taaactttta acacatcaaa 57060
caaatcactt cttttatcaa tagctaagat gttgttttca tcttcaatgt taaatccttc 57120
ggatacttca taaagtgtca cccataaatc acctatatcg atagtagcat ttccttttcc 57180
acgactttca agaatatgac aaattttctt gatttcgtca taactcattt taataatatc 57240
atctccttga ataaggaaga tgtcattttt aaattcaaca cgaattaaac cactttcact 57300
tgaaataaac atatttcctc actttgaaat catagttgga atgacagaat caagataagt 57360
ctttagcgca atagcttcgt ctttggtaaa tgtgacaata tgtgatcgaa aatcatcaat 57420
ttgacgaata gttaagacat ctccttcttc ataacatttt gatacattta aaagagtttc 57480
atcattctga ttgcaatcgt tagtaataat agcattgcaa tttttgagcc attttaaact 57540
atgttttctt tcattagaat aataaaaata tttaatctta gctataaaac tatcccaatg 57600
gataactgat aaacacattg actcactttt aatattaaat cctgggcatg aagaataaaa 57660
atgaattttg tgctcatcat tgatgcttac tattttatca gtataaggat attcaatttg 57720
ggttaaatga atgatttcac taggcgtaaa atacagcata tcgtcttctt gcgtcaaacg 57780
atacatgtta tttacttttt ctatagccaa ttcaccaaaa agcggactaa cttctaatac 57840
taatcgtttc atattgattc tcttcgactc actcacaatt acatactcct ttgaataata 57900
tcaataatgt tgttcacaag attataagta aacattgggt gataatattg aatcatcaca 57960
tacacaacaa acaaaacttt cattctcttc tccctggcag ttgacaagat tactatacca 58020
taaccttgcc aacttgtaaa ccattaaatg acgttttcaa taaaattctg gagttttgtg 58080
tgagcatcaa ccatgatttt catttcttcc tttgcgaaag ctgtacctct ttcacgagaa 58140
gaatactcat agtcagaaac tgcattagca tattcttcaa ttagcttcat taaaaacatc 58200
tgcttttcag ttttcattat tccacctaat cattccaaga tattgaacta acttagcttt 58260
agatttatcc aaatctcttt tagctgcttc tataccatcg tatgaatatc cttcacaatg 58320
ctcaactgct aattgatatg aatctatttc aatatcacgt gctaatttaa tgattttttc 58380
aaactgttca cgtgttagca tacttaaact ctcgtattat gatcgataat ttcatcaaga 58440
aacatatcta aagcttctac agcattatca actttagctt caagttcttc agcgccttta 58500
tttgcaatgc ctgccgaaaa ccaagcaaag tcactaagtt cctcgtctgc tttacgaatt 58560
aaagctacca attctttaat tttatctgct tgttcgatac taatcattat tccaccacat 58620
atgaaagaga gaatatcgca cacgccatat gagttgcagc ttcatcacac atatcataac 58680
gtttcttaag aagtttttca agttcttcac tagtaacttc atccatgtcg acgaaaaaat 58740
caccattaat gatgacgtag atatttcctt cttgattaag tgcttcaatt ttcatgatgt 58800
tctcctcttt atccgatggt tgtatagtat cacagctcga atggaaagta aaccggtaaa 58860
atgaaaaaag tctcccgaag gagactaatg ttattcgagg gaaagaagat atttactctg 58920
gtaaaacatt ccagtaatat catctatcgt gctttgaatg gctggaggca tttctttata 58980
aatgctgtta gattggtcta gtatgcgatc aatcatttta attgtgtcgg taggaagttt 59040
actagcatct ggaatagaag gcgtgtattt tctaccagaa taccccaaat attgctcacc 59100
aaatttatca atcaaatctg gcaactcaga gaaaataaaa tcgtatgctt tgtgtctagc 59160
ataactttta gtttcaaaat gcgcagaatg aaaataagct tgtgcagcca ttaataaacc 59220
taagtattca tctgcctttg aaggttttcc actttgtgaa aagtcgctga atttcattca 59280
gtctccaatt taatgttcat aattctagcg tatgattgtg ccatctccgc gcctcgttct 59340
atacattcaa aatcggaaga gcacgggtca tttttatagg tcgttcgcat aaaactatag 59400
aactgttcag atgattctac gcttttattt tcaaaaagca tataaacgtg tctaatacca 59460
gattccataa atttatcaaa atgaggatcg acattcgctt caatcggtgg agataaagca 59520
aacgctaatc ctagcatggc aaatagtgcc gttgctttta aggccataaa ggcctcctat 59580
catttttgtc ctgtatttac tttgtgccgg tgcacggcct taactttatc aaggtatttt 59640
tcaaaatttc gcaatctagt atagtctgcc ggagattggt tgagtgatac ttctcgacgc 59700
aaagctgaaa tgatatttcc aacttcccta cgaatttcat ctaattgaag aacagtaaga 59760
ttgcgaagtt gcttttcagt taattgtagc atatataccc ctttagttag ataaacctat 59820
ttataacttt tgcactaacc gagcttttta gttaattcat tccaatgttt tctgcacaaa 59880
gaaacataaa tttcatcacc aatacagatt tgattacctt ctttaactgg tgttccatct 59940
tccattaatc gagctgtcat aatcgctttt ttaccgcaat gacaaactgc ttttagttca 60000
ataagtttat ctgcaatcgc caaaagttct ttagaacctt caaataattt tccagcgaaa 60060
tcagtcctta gtccataagc cataacagga acattatatg tatcaacaat tcggcttaat 60120
tgatgcacct gttcagtttt taaaaactga gcttcatcta caaatacaca atgaatatct 60180
ttttgtgctt cagcccattt atagaactca aaaatatcca tatcatccgt aataatattc 60240
gcttcctgtt taattccaat gcgagaaacg acttcacaga cagaatcgcg agtatcaata 60300
gcaggcttaa gaactaatac actcattccg cgttctttat aattatgtgc agcagtcaaa 60360
agagaagcag attttccagc attcattgct gcataagtaa aaattaaact cgccatatca 60420
ccttcttaaa gcgtattcac ataagctatt aattcgtttt ctttcttatc aaatcggtca 60480
gcaaattctt cttgctgttc gggagatagc gggccgtatt catcataaaa ggtgtttgct 60540
tctgtatgct catccaaaag ctcatgaata agctcaaata atctactttt ctgactaatg 60600
cttagactca tatattaatt tccagaagtt ttaaaataat tcgcttttgc ttaaatattt 60660
ccatagttaa atgatcagta tctttttgac caattccaat ggcaaaacct ttattaacag 60720
cgagttcaat taaattatca agctcacgta acacttcata ttgtaactca aaattattca 60780
ttttggtttg ccttctttaa cgaaatcggg ataaggataa aatcccgaat aaaatccttc 60840
gcctttatga ttgatgcatc ctttattaga acaatagcac caataatcga aatcacaagc 60900
catttcatca ttgcataaag caaaaacaac tggccattta cacttttcac aatgtgcatt 60960
tttaagaata ctagtttggc tcataaccat gtaaccttta agcaatattc ttctacatgt 61020
tgtttacgac ctttcttatc aataaaggta tattcaacga atgttccaat atagtcttta 61080
tctacatcat gtggactatt aattgggcat ttagtacggc aaatgcgttc ccattgacga 61140
ataatttctg ctttgttttt aggatcaaac ggatgcgggt aatgtgcttt cataatccac 61200
cactattaaa tcaatatcag gagtaaacat gtcgattaat ttagaaacct tatcccaatc 61260
accgccagca ataccacaac ctatgcgtgg aatgtaaatt actggtttaa acaaaagggt 61320
ctctgcctgt agatttaatt ctatcatgca gtttactaaa gcaccataat caagattagg 61380
acctggttcg tattgtgtat acagattata gcatatacca aatcccgcag gactatgttt 61440
aaaaacaata gacatatcgc ctaatttatc acgagaacca tattcagtag tggttttatc 61500
tatttctaaa attttaggat aggccctcgc taattgacct gctacacctg aacccatagt 61560
atgaaaacaa ttgcacccgt gcgcaataat attaccttga agaaataggg cgacaatatc 61620
gcccttgata tattttacaa tcatctagta ctcaatcctc gattataaga atctaccaaa 61680
cggtcaacca ttgaatgaca agcggcttta tctttctcct ccgcaactga acattctaag 61740
gtattccact ttttagcata tcgttttaat aaagtatcat ttttgtatct gcttgattta 61800
tctctttctc cgtctttata tgcatatatt aatttctgcg caaattcagc ttggcatgct 61860
ttatttttcc cgcaataatc cgcggcagta cggtttacat actctctaat ttcagtatat 61920
gatgtatttg ctaacgcaga aaatgaaatt aatcctatac ataaaaccaa aattttagtc 61980
atttactatt tccaaaagtt tattattttt aaggtagtta gccttttcta ggacttcaga 62040
agcatattta gaacctgctt taacattcca tcccgaatta taagaggata tcgcctttct 62100
tatatcgccc ttatgtatat ttaaccaata agaaagttca atgtacgccc aggaagctga 62160
attggatcgt ttattcaaca ttctttttat ttcagcatca gtcatattat aaccaagttc 62220
cttaactctt gctcgcatag ttggcaaata attttggaac attccatagg catgatgttt 62280
tggtttagat tttaaattaa ctccggcaga gctttcttgc cataaaatag cagccattat 62340
atgacctaat ccgcttttat ggatattttt gtgtgtttta tattttccat ccttagaaaa 62400
ttgttccccg aattgatacg cgtaacgcat gttatcgagt tggacattac tgaaagtatg 62460
ctcggagcta tgtgccatca ttgaaatggc caatagacca gcgagtagtg cttttctcat 62520
gcttacctca ttgagtttta attactgctt tagaagcctt tcctggtaaa cgacgactgt 62580
tgataattgc catcctgcac tgaagtgacg ggtctttgaa cttcgcgtta ggtttacaaa 62640
ctgtaaatcc aagccaaaga tttccatctg tgatttctaa acgtccagga cgatattcaa 62700
ccccatcaat aaaatcctcg tcaatgtcag ggcgtggagg catactcagg aattcattaa 62760
cttctaaaac atggtctttt attttatgga ataattcaaa aacatatgtc tcatcaatct 62820
cccgttgaat tgcacgatca agaagatgtt gagaatattt tagatgaaac gatgagactc 62880
ctgctgcttt tgatgcctca cgaatctcat tgttaatttg acgaaactcc gactcaaagt 62940
gacgacggag cttatttcga cggataaaaa cttctgtgtt gatagtcatg ttattctcct 63000
cttaactgat agaaaaatta taccacagtc aagaggaaaa gtaaacagtt attctttaaa 63060
tctaatcaat ttattcatag actttgtaac ttctgcacga acctcatgca ggtttttaag 63120
ctgttcaaga cgttgctcat agtaagcaat ttcatcttct tcgagacagt cctgtgaatc 63180
ttctttaaga taacgcgcat agtcctggaa agctttacgg actacttcct ggaagtcatc 63240
aagactttga attttcttag gagcaacaga tacacgacga ggggcagtat aatactcata 63300
accaaaccct gcgcttaatt gagccattaa tatttttcct ctggttggaa cacagcacga 63360
caagcccaca tactggcttc tttgagtttc gttttagcaa tagttaactg atcaagactt 63420
tcagcataat tctttgcgaa ttcacagtct tcacaattat ctagtgcttc ccagaattca 63480
tcatataaag catcaaagat aagtcctaaa cgaacttcag catctttgat agcattcact 63540
ttaccgattt tctcttcagt atgtggctta taacccttaa tatcttcaat catattttac 63600
ttcctcacca gtacctaaat catattcaac taaacgaata ggttcatgaa tgccatatcc 63660
ctgaacagaa atttctgtcg taggataaat tccatcaata tcacccatat tccatgcttc 63720
attaaattgc tgttcgcctg aattactaaa ccattcggcg aaagcattta gcacatcttt 63780
agaaccttca ataattatct ttgccattac aagctctcag taaaggtacg agcgataacg 63840
tcgcgctgct gttccggagt cagagagtta aagcgaactg catatccgga tacacggatg 63900
gtcagctgcg gatatttttc cggatgctta actgcatctt ccagagtttc gcgacgcaga 63960
acgttaacgt tcaggtgttg accaccttca attttaacag taggctgtgg ttcaatttca 64020
atttcacggg catgcaaacc atagaaaatt tctgggtcta caaaagagtc ctctttaaag 64080
gttttagaaa caataattcg cgcttgaata ccatcttcaa aataaatagt acctttatgc 64140
gtgccttcaa gaatttgata tgctttcata taacctctca attagaaaat aaatttatcc 64200
aagattgttc tttaattaaa aatggctcag aatcatatgc cattaaactc tgcgtgatta 64260
gtcctttaaa aggcccatca ataaattcca tggtaaaata tggaatttta ttcattaatc 64320
ttgcattagg agccgtgcac aaaactctgc atcctttgaa tacgcctttt tgtaatttgt 64380
attgcttagg ataaaattcg ctcaagacgt tgttatttgc caaaatttca aaatgattca 64440
ccaatttatt tttaatagtt tttggcgaaa aataaagata ttcgaaaagt tgcgtgtctg 64500
tcatcattgc attccgatta cgaaaaactg cggacgagta ataccaccaa tgcaacaatt 64560
actattgcaa cagtggtgca cagtttcaat atgaatattg taaattttat ccatatcagg 64620
agatttaaca ggctcatcga ttatatacaa aatccgcgaa agcgataaac ctctgaactt 64680
gcttccttta ttaccgataa aactacggac agaatcggta aataagcgga atcgaatatc 64740
atcgccagaa taacgagaaa attctttttt aatgtggtcc gcagaaattt tagcgtaagc 64800
tgaagtatta gaaagaacaa taactgttcc accatcatac agccaattag cagcaaagtt 64860
agtcacagca gttgatttac cggattgtct gccaccatct aatcgaagtg tgcaatactg 64920
cttgagtaag tcttcaaatg gtgggatata atcgttttta caaatttctt ctactctagc 64980
atcagaatgg tgtgtaaaag cattcatcag ggatagataa ggaccagtta aaaatgttct 65040
cattttattc tctctaaatt tgggccattc catggcgcat gaattgtcca tttctgtatt 65100
tacccattac cgcacttggg ctcgacctta ttacaggttg gcgggaatcc ctcatataat 65160
catgaggtcc aggttgttcc catgttattt gaatgtaaat aggcctaagt atcggcctta 65220
ttaattacca cgggctgcat tagcaacggc gtaagcgtac tgaacattag cgtccttaaa 65280
cgtaccttta gaggtatcta tttctgcctt aaagccgcct ttagccataa catcggcaaa 65340
ttctttacgg aaagccattg catcaagacc tttccatgat gatttgtgct tggcgaattc 65400
aagaccagcg tagttgacag ccttagctaa tttattatca atgacccatt taccggcttt 65460
aggcacaaac ttcgggcctt tttgtttaga gaacagtttt aaattccagc gacgaagatc 65520
actgtcggct ttaacaaaag ctgcgtctaa gttactagca acaacatctt caatatgagc 65580
aaatttaagt ccgtcaactt caatatttaa atcggtacgc cagcgaagtc cttcccaagc 65640
gaaagcttta aaatcggaag cttttgtagc taagtatcgt tcaataggag cagttttagg 65700
gtcaaagccg tttccaccac gatagttcca ctcgtcctta ttaatgcctt tggcctttac 65760
tacagaagct tcagcaataa attcttgata cgttttcatt tttgttccta ttgttttaat 65820
tcatgttatt ctttagggaa gtttttagag tatgcgtcat aaagtttatt accgatgcga 65880
cggaagactt tagctgcaaa acggttttca gggtttttaa tcatgatttg catcatgtaa 65940
gttcctgcat ccgaaagagc ttcttcatag tacccattaa tttctttaag agtcctacgt 66000
ttaccaccag gtccatcaac ggtaattttc catttacctg tagaagtgcg gctcggtggc 66060
tcaacttgtt caatccaaat ataaccacct tcaacacgtt ggttggcgga ttctgcaata 66120
aattcttgat acgttttcat gtgtttcctt gtttgttttg atagagtaat tataccatat 66180
taatacttaa gcgtaaaccg tttaagcttt accgccagaa ataattccga agttgttaaa 66240
atcatatcca atatcgtcaa catctacttt agggcttgct acaacataag caatttcact 66300
acgttttgca taggtgctga tttctttacc atcaccacct aagaaaaaat acccattacg 66360
ttttaatgag ccaaagtctt ccgcatcacc aatgaaagct ttaactttaa atttagaacc 66420
tttggcatct gcttcaacga taaattcttg atacattttc atttttcctt agtaaattga 66480
tttaccaaag tatttgtacc aagtcggacg ttgagcaatt ttttcatcta agcgtgcttg 66540
atttatcgca atggacgctt cggatgggtc ataatttcct ccaagtagtt gatgaatgta 66600
tagtatcaaa gtccttggag gaagtaaaca ctatttttct gaagcgcctg aaatatattt 66660
ttcaagacgt tgtttcatta gcgagccgtt cttagcgatt tcttctggtt tatcgcacat 66720
acgcaacaag gcttcaagct taacgatatc actggtacgt tcaaatttgc gagtatctat 66780
cttactagca agttcagaaa tacgtgctaa tagactttca gcttcaacca aagctgcacc 66840
tagcttagtt gcaaatgtgt cagtagcttc gttaagaata gattctgata aaaattcact 66900
atatgttttc atatatacgc tttccaagtt cctgttttaa atgttgagat tacgcgtttc 66960
gcgcgattag gtgtctgacg ataccattta gattgggcta gatttactgc tgcttcatcc 67020
cagcgttttt gttggagcat acgtagagaa ttagtaaatc ctgctacgcc agtttctccc 67080
atttggaaaa ccatgttaat caatgcacag cggcgaacag catcaagaga atcataaact 67140
ggttttaatt tagcatttct cagaattccg cgaacagcag catcaacatc ctgattgaag 67200
agtttttcag cctcatcttt tgtaattaca ccattgcaat tacgcccaat agctttatct 67260
aattcagatt tggcaacact tagtgatgga cttttagtaa gcaaatggcc aatgccaata 67320
gtgtaataac cttctgtgtc tttatagatt ttaagtctaa gaccttcatc tatacgtaac 67380
atttcaaata tattcataat acctcctaag tatttataga aggtatttat aaattaaaag 67440
aggctgttca ttattcggta aagtgaaggg cccatcacat attgccactg agtacgagga 67500
ataagggcaa aagcatccat ctctggaatc ataacaccat ctttattttc aaaataagac 67560
tcgcaatggc aatttctgaa catctcatgc tctactggaa tcgtataata aaacaactgt 67620
aagtctttat tactagaata tttaaataca cctaggtctt ctagaaggtc tggattataa 67680
ttactaaaac cagtctcttc taaacattct ctttttgcag cttccagtac attcaaatca 67740
gaactttcta cacggccctt tggaatatcc caacgatgtg ccatcattcc aggcttacga 67800
gaaccagtaa cccgacccat aaataaatct ttatcttctg tcataaagat aataccagct 67860
gataatgttt tcattttaat ttcctgcatt cagtgataaa gttatttaaa ttttgagtat 67920
atttcttttc atcaaaaatc ttttgctgcc tacgtaaccg ccatggcatt tcaatgaaca 67980
cgcaccatat tcctgatagt actgctgctg taaaaatatt aacaagtata attaaaagaa 68040
tccaatcttc cgttctgcct actggacttt ctccaaagaa gcaaaataca aatgatgtca 68100
caggaaaact aataatatac cacagaatca taatcttatc tgtgaaccaa tcagcgttcg 68160
ttaatttagc gcgaccgttt cgaatacaca cgaatttatc atctgtcgca gtagatggct 68220
taactggttg atatcccatt ctaaactccc taatcagcaa atttttcata tcttcggaac 68280
agccattcca gtcaactcta tcaactgaaa tgccatcatc cccatcatct aaatcatacc 68340
agcgagtttt taaaatcatt tgattttcct acaatcactc acaaactctt tcattgattc 68400
attttcaata taagacatgt agttattata ttcttttaat tgtattttgt aatccttttt 68460
tctttgccaa tttattttaa aattatcata atgaaaatat aacatgatgc caaagaatga 68520
aaataatgaa attgctatag tataatgaag ttcactccaa acttctatta tatctactat 68580
accgctgacg ttactgcgga tgtttaaaat aatacagtca atcattaatc caataagact 68640
accagcaaga gctgcagcca acgccacagc aaaaattaaa aatgactcag aaaacgaata 68700
tttgacttta tttagttttg gcttttgcat cgtgattcct taacaaattt cataatttca 68760
ttaaattcat actcagcaag tttaagctgg tgttcctttt taatcttttt acactgagct 68820
ttccaatcgt gtacacgttt acgataatgt cttccttgat accagtatcc tacccaattt 68880
acgggtacta ataaaagtgg aactaccaat ggaagaatta gcattaacac aagtatttcg 68940
ccagaatcaa tatcagtcat aacatctaaa acacctccaa taatcaatag aattacaaat 69000
gatataagta taacaggacc tattaataca tcagtaggaa ttagctgacg ctttagttca 69060
tacttcacag gtttacttgg aaggtatagt gatggctttg acatattctc tacattcctt 69120
aacaaatttt tctaataata aatcgctttc aaaattagga ttttccacga atttatcaaa 69180
aagatcatca acgatagtta agatattctt tttattaaga atacgcttat tttcatattt 69240
tgtttcagag tcaactataa gagtaaagaa atatttcttt ccctgaaatt ttaccgtagt 69300
atcaatatag aacaaatttg acttttgtaa attacgttta aaccatgcgt cacttaaact 69360
gtaaacgcca agataatcat aatcgtcatt taaataacaa actgtccatt caggagaaat 69420
gaaatcagta aattcaacat caaaatcaca cgtcaatgaa tgaattgatt caatactttt 69480
aatgagtatt ccaggacgta ttaaagactt tttaccttta taaaatccag aaagactttc 69540
atcagtttcg tatgaagacc cccaatagta attacgtcct tctgccatac gtttaagagc 69600
atttagtaat tgatctggaa catcaacctg tctttggaac tcttcaaaca ttgaattgaa 69660
atcactttgc attttcattc ctatttactc caagtaatag gggccgaagc cccttatcat 69720
tatttcagag aattaatata ttcctggaca tcggcagagg tagtttcaac cccagaaata 69780
ttgccgttaa atgtttcaac tcgagcaagg gtatcttcaa tatcaacctt agtcagtgct 69840
gcaatttcaa ctacatcatc ggcagtacta attccaaggg catttgccgc acgagtttca 69900
cgaatatatt ccaatttaac tgcaagttct tggcgagcat catctaactc aactactttc 69960
ttggcgattt caattcgcat ttcagcataa ccgtcagctt tagtagtcaa ctgctcagct 70020
gttcggcgat atagtaaacc gagtttagca tgcattgtta catcttgacc ttcggaaaga 70080
agttttcgaa tttcacgctc ttttgattcg gcctgtcgat tcttttcgat aacaagttca 70140
cgaatacgtt tttcttcatt aatagattta atagaagcag tttttaagtc tttaatttta 70200
tcaagtagtt ttgctgctgc agcagtatac tgttcttcga cagatagatt tttagccata 70260
gcagaaccaa gtttagtgcg aataaactca acaattttct tcagtgtgtt catagtattt 70320
ccttagattg atacaattag ataatatcac gtttttaata gattgtaaac ttattcttcg 70380
tctatctcat cgataaagac gtcaatggcc tcgataacgg catcattgat agccaataaa 70440
gtaaaatcat cgtcagtacc tttataagat tctgaagcat tgatatatgc ttgattgacg 70500
agttcccaag cctttttaaa ataaggagtt tcatcatcag gacaaatatc ccgcacacct 70560
tcaaagatac gattggcata atctaacacc cattgtacag gcatgttttg agaacgttcg 70620
ttaaactctt taaattcctt agattcaaaa agctcttcgg gataataatt tcgattacaa 70680
aaagctttac taaagttacg tttcataatg ttctcctcaa gttacaggct cataatatct 70740
caatcatgag cctgtgtaaa cttatttcat attattgaaa tattcttctg cgatttcgtc 70800
gttatcatgg taaactttag aagacagttt aacataacct tctgctgtga acatgttaat 70860
cacaactttt acagtatacc actgaccgtc ttcattaccc attactgcgt aagtttcaaa 70920
catcggatgg tcaggaccga taactttaat atcattcacc gtacgaccaa aatcttctga 70980
aacgcatttc ataaagaagt tgaacagttc gccgtaatta tccatttcat tctccaagtt 71040
gttttctgta tcagtagttg atagttgtat agtaccatgg aagaacaggg atgtaaacag 71100
ttttgtgaaa aaattttaaa aagttttggg gaattctagg gcagggaggg gcaattaaag 71160
gataggataa tatattataa agggtagaaa ctaaatgatg cctagagagg tccagaaagg 71220
cctagatacc aaaaagcccc aacctttcgg aaggggctat gccttgaggc aaccttgtcg 71280
gggttccacc tgcaaggcaa gtgtttgtac gaaacgccgg gattcgaacc cggttattaa 71340
gcagttgacg ctactcaata tttttaaaag gccatatctc gaccatatcc gaacgttccg 71400
tcaaaaacgc tactcggctt acggcaaaga tatttcctcg aatcgataat tctgtgcgcc 71460
gtttcagctg tgatagtaaa gaaccagaac acagtaaaac tatgggagga actatactcc 71520
agggaacatc agtccgacga cttaccggta gcgacccggt ttctcatttg gtatcccgcc 71580
ctgggatcga accaggaccg caaacttaga aggatcgtat gctatccatt acaccagcgg 71640
gacataattt aaaatttcat ttttcgacct ttaaaccatc cttctggaat tgggtcagtt 71700
ttcttaatac gtttagaaac tttttcatct aatgaatgaa tccacatcat accaaattgg 71760
gaattctttt cgccctgttg atgtttattt ctggcgtgag attctttcat tttattaata 71820
gtttcaggag tatgatgctt atttaaaaat ctgctattat ttaaaaattt ttccctgtat 71880
tcaggagttg accacaagcg tttaaataca tttgaaccat gtttacgata tttttcttga 71940
agtaaaatat catttttaaa acgtgactta aacgatttag ctccttttaa actagcgtct 72000
ttcttctggt ttagcatccc aggaatattt atatggtccc atccaccttc accacctaat 72060
ttcaaattat aaacatcagg gcgctttaaa aactcttcag tcacaatatt cttttctgac 72120
tcaaacatag aggttttatc gtcaaagaac tctaatattt ctttagaaaa attttctata 72180
ccatacttat cttgggctct ttttaataat ttaccagaac ccatatatcc atcatctaaa 72240
ttttcggtag aatgagcgcc tatatagatt ttattattaa ttttatttgt tattttataa 72300
atgtaatgga acataaatat ctcctatttc taagagtatt tatgttccca aaatatggcc 72360
ctgggtggaa ttgaaccacc atctggcgat tatgagtcgc ttgcttgaac cttccagcta 72420
cagggccttg atatgctgat tgacggaatc gaaccgccga cgtcctcatt acaagtgagt 72480
tgctctacct actgagctaa atcagcgaaa ttacggaggc gataggattt gaacctatga 72540
gtcgccggag cgactgccgg ttttcaagac cggtgcatta aaccactctg ccacgcctcc 72600
agtctccgcg gcaggatttg aacctgcgac attctgctcc caaagcagac gctctaccaa 72660
actgagctac acggagtaaa ttaaatttga gcggataatg agaatcgaac tcacatcatc 72720
agattggaag tctgaggtaa tgccattata cgatatccgc aaactttggt acgagaagtg 72780
ggactcgaac ccacaaggaa atcattccgc agcattttaa gtgctgtgcc tttaccaatt 72840
tgaccattct cgcgctggga ataaaggact cgaacctttg catcctggaa tcaaaatcca 72900
gtgccttacc aacttggcta attcccaatt attaacaaag gctctcaaac aagaaccctt 72960
gatgatagag ggtattaatc agtgcgatat gagttaataa taacaaataa ttcttaaagc 73020
atatttacca tttatgataa tacatattta cgatgcattc aagacccaaa ggattcttga 73080
aaatatcata ttcaagagga cctttttctg tttcaataaa gaaatcaaaa tttactgtgt 73140
taaatttacg gtcttccttt actaatttaa cctgcgaaga tgaacgatca atgtaaacct 73200
tttcaacttc aaaacatgtt aaaatgccat aatcatcaat caaggcttta gctgcttctt 73260
gatcatattt atatccattt tcaacggacg atacttttgc ataaagaatc attattaacc 73320
tttatcaaca atagtatgag tatgggcatt tacaatttgc caccaatcga aactatcgcc 73380
aaatcgtttt gatttattgt cttcaataat ttgacgtaat tcatcttctg tttcagcata 73440
cgcaatcaaa tcatcatatc caccacaagg atagtaatta tcgcctgcga acaaaagaaa 73500
atttacttta gatgggtcta cataataatg ctctttagga tatttagttc ctttccaatc 73560
agttacttca acataacggt aagaaaatcc atttttactt tcaacccaac tccacgcttc 73620
aaaaggagta ttaaaaactc tatcaggtat taaattacct tcaaaatgag aaggatttgc 73680
ataatcccca gcataaacat aatattcgtt aatattcatt tattcacctt tagaaatttt 73740
atccataacg atagcaatta aaccaattaa aaatgatact acaagtgaaa acacattttc 73800
tgctgtagtt aataatccgc atataaatcc aacaaacatt gaaaaactaa aagcagaagc 73860
agaaattgca atagcaacat ttctaattaa ttcacaacgt ttcattttat tctccttagt 73920
tgatagggta atagtatcac aactaaaacc ctatgtaaac aactttgtga aatatttatt 73980
acaaaagatt tttagcaata atcttgagat gtgccgcaga aatgtgttta gctttaaaca 74040
atgcagtttc ttcagcagga gagataatga ttgtagcacc atccttttta gcagaccacc 74100
catcacctag gtaaacagta cctttgattt cttcgccatc aaccaaacta atcattggtt 74160
taccttctcg tcctttattt gctttaataa cttcagaagt aagagtagct tcagtaatag 74220
tagaaaccgg gatagttgta gaagtaaatt ctttgaaagt tttcatttta ttttcctaat 74280
taattttgat gagataatag tatcactacc tcatcaacgt gtaaacaact ttgtgaaatt 74340
attttaaatc atctgcccaa tcgagtttaa gaggctcttt gtattcacga tctaatacga 74400
ccggaatttg tacatcaccg ctaaatgata agggcccaac attataagac aatgttatat 74460
gcggtgtgta atcatcaaaa tcatgtgtag cacctagtgc ccgcgcatac atgtgtcgac 74520
agcgcagata ttcagaatct agcacaagta caagagtcga tccatcttgt gttttccata 74580
cttctaaatg tccagaagaa gctacttcaa aacttccact tgatggaaca tacggaacat 74640
ttactcttga ataacatatg gtcgaatgaa ttttttctct aggaactgga ttaggaacac 74700
gtaaagagcg ctgaagttct tccagcgcat caagtgttaa ttctgaaaac ttagctgcta 74760
cataaagacc cgttgaaaag tctttaaatt ccattattct tcatcttttg cttcatcagc 74820
agattcagca gtaagattct tgacagcttc aacgatttct tcaactttga tagtatcgcc 74880
agtgatacct actgcacgag caatttcagc caaagttcct tgtagaattt tggattcttc 74940
catcagacga gccgcctggt cctgcgtatc aagaatacga gacttcagag ttacgatttc 75000
agcagacagt ttttgttcaa tagtttgttc agacattata gtacctttag tgtattttta 75060
attttagaaa aaagttcttc aagagaacca tcgtttgtaa ttactaaatc gccatcacga 75120
attggcaatc cagcttctgt aatatgagta tcattggatt tttgaccagg acgaactaca 75180
tgaattactg tagcacccat cgccctagcc gcatccattt catgatcttg acgagtatca 75240
ggaacgatat aataatcata aactgagtta aatttatcaa gataatctaa agcaaataat 75300
tttacccaat acatgcggtc gaagttatta acaatcaaat ccgtacctag ggcttgcatc 75360
agacgacgga ctgaccattg atcttcaata ttatttataa cgtcagcaat cttgttaaat 75420
gctacgaaat taactgcgtc atcaaaaaca aacacacctt taattgggct tttactatta 75480
agatagcaaa atgcttgttc cataatcgta attacttcta atttagtcag atttaaatta 75540
gtttcacgat catagtcaat tccttcaaac tctttacgag ttaagcaagg atagtcagtg 75600
tttgctgcaa atacgcccca tgcataagcc aatgcatctt taataggacc agcaagttga 75660
tatttaactg cagaataatt attcatgata aaatctgcag tagtatcttt tccactacgc 75720
tttacaccac ttaaaaagat tagtttcata tgtttctcct caaatttagt taagattata 75780
acacatgaaa ctgaagcatt aaacttctgc tataattttg ccatcttttt ctacttgaaa 75840
atacgtataa ggaatcgttg ctgtgcatac taaagctggg tctgaatctt ccgtgtagct 75900
aaattctact tcagacaggt ctgaaaccca aggcttataa aaatttattg acatcacgat 75960
ttcagtttta ctattatcta aaatgtaaag cgtaatgtat tcaggacctg ttttttgggc 76020
agtattttcg cctgtaagat agttactagt tcctagcatc cattcataca ttcctatcca 76080
tgacttaagc tcttcatcaa ctataaatct cacgatgagt gggtcgtact caaatgtaac 76140
acctggacgt tgtgctcggc ctagtccaaa cggcccagtc acggtatcag taacaggtat 76200
cctaattcct ggaataggaa ctgactgagc atttaaagta aaagcagatg tagtattact 76260
atgcggtatt gatactacaa agttagttgt atttgcttgg ttaaaaattt gttgcagtgc 76320
ttgcgacata tattcctcat aatgctttat aaatgttggt ggtataatgg gtctaagtct 76380
cttccattca attccaatta gaacaaacaa tagaaaagaa tggaagataa tagaattaga 76440
tatttgacca gactttgttt gcagagaaac gttttccttt tgaaacgaac tgctgaagtg 76500
gcattaacac aacgttcgcc cagtctttcg gggcgatttc aacaaggcta cccatgatat 76560
taccaggtat atatgcctta atcatttggt ctgcacccct aaatcctttc acttgactcc 76620
aatcaatttt taatttcgtt ttattagtaa tagtaggtgt attcgaatat tgctttaaaa 76680
gctcttctag aaattgctga cgagctttag gtggaatata gtgcaagttc aatccgtaca 76740
ttaaattatg tttacctaaa ccgaggtaaa ttatcaaagg aaatttatcc cagtaaggaa 76800
gagtttcttt gtgtttagca tcgtaagcaa aagcatatat tcgtcccggc tgcgggcgaa 76860
caactttatg tccttttacc tgcttaatag tttcagcaaa ccactttctg gttttattat 76920
taattgctgc accttcatta cgaattttat cacgcaatgt ttgcctgaat gaatttatca 76980
taagcagttg tctttcttgc ttattgagtt tattcattgg ttttgattca agcttttgaa 77040
tcttttcagc cgttttaatt cctgaagcat attttgacat tgccgaagta aacgtagaat 77100
atttaattcc tctttcttca gcaaattgct ttcctgtcat tccttttgct ttggcctttc 77160
tgtattcaag acctatctga atccatttct tttcgtttaa tgattgctta acctttggaa 77220
cttggggagt gctttcatta attatttgaa aaatagccat tatgccccct taaagccaag 77280
agctcttaat ccatcttctg ttagaattct aaattttatt ccacgctttt cagctaaagc 77340
ttgagctgct ttccatttgt cagtattaac ggaatatgta taaatttcat tcataaatct 77400
tttcttcgct gcagttgtta gatgtgctgg tttaactggt ggttgtgttt cttttttagg 77460
ttttatttca ataaaaaatt cttgtccaga agaatctttc atccaaatat ccatgaagta 77520
tctacgtttt ttcccttctg cattacaaaa ataaggaatt actgctgttt cactacccca 77580
tgcaataatt tctggatttt tatctaacca ttcaaaaaag aatttttccc aatttgatct 77640
atacgtaatt tttttagggt cacctctata ctttgatata tttttaggaa cccattttcc 77700
agaatatgcc attggattct ccttataaat agataatata tttataaaca ggagggccca 77760
tgctctttac attttttgat ccgattgaat atgcggccaa aacggtgaat aaaaacgcgc 77820
cgactattcc tatgacagat atttttagaa actataaaga ctattttaaa cgcgctcttg 77880
cgggataccg cttacgtact tattatatca aaggttcacc acgcccggaa gaattagcaa 77940
atactatata tggaaatcca cagttgtatt gggttttatt gatgtgtaat gataattatg 78000
acccgtatta tggatggatt acttcgcaag aagctgctta tcaagcatct atacaaaaat 78060
acaaaaatgt aggtggagac caaatagtat atcatgtgaa tgagaatggt gaaaaatttt 78120
ataatttaat atcatacgat gataatccat atgtttggta tgataaaggc gataaagcta 78180
gaaaatatcc tcaatacgaa ggagcacttg ctgcggtcga tacgtatgaa gctgctgttc 78240
ttgaaaatga aaaacttcgt caaataaaaa taatagcaaa atcggacatc aattcattta 78300
tgaacgacct tatacgtata atggagaaat cttatggaaa tgataagtaa taaccttaat 78360
tggtttgttg gtgttgttga agatagaatg gacccattaa aattaggtcg tgttcgtgtt 78420
cgtgtggttg gtctgcatcc acctcaaaga gcgcaaggcg acgtaatggg tattccaacc 78480
gataaattac catggatgtc agttattcaa cctataactt ctgcagcaat gtctggaatt 78540
ggaggctccg ttactggtcc ggtagaagga actagagttt atggtcattt tttagacaaa 78600
tggaaaacta acggaattgt ccttggcacg tatggtggaa tagttcgcga aaagcctaat 78660
agacttgaag gattttctga cccaactggt cagtatccta gacgtctagg aaatgatact 78720
aacgtattaa accaaggcgg agaagtagga tatgattcgt cttctaacat tatccaagat 78780
agcaatctag acactgcaat aaatccagat gatagaccac tatcagaaat tccaactgat 78840
gataatccaa atatgtcaat ggctgaaatg cttcgccgtg atgaaggatt aagactaaaa 78900
gtttattggg atactgaagg atatccgaca attggtattg gtcatcttat catgaagcag 78960
ccagttcgtg atatgaccca aattaataaa gttttatcaa aacaagttgg tcgtgaaatt 79020
accggaaatc caggttctat tacaatggaa gaagcggtaa ctttatttga acgtgattta 79080
gctgatatgc aacgtgacat taaatcacat tctaaagttg gcccagtttg gcaagcagtt 79140
aatcgttctc gtcaaatggc attagaaaat atggcatttc agatgggtgt tggcggtgta 79200
gctaaattta acacaatgtt aactgctatg ttagccggag attgggaaaa agcatataaa 79260
gctggtcgtg attcattgtg gtatcaacaa acaaaaggcc gtgcatctcg tgttaccatg 79320
attattctta cagggaattt ggaatcatac ggtattgaag tgaaaacacc agctaggtct 79380
ttgtcagcaa tggctgctac tgtagcaaag tcttctgatc cagctgaccc tcctattccg 79440
aatgattcga gaattttatt caaagaacct gtttcttcat ataaaggtga atatccgtat 79500
gttcacacaa tggaaactga aagcggtcat attcaggaat ttgacgatac cccgggacaa 79560
gaacgataca gattagtcca tccgactgga acatatgagg aagtatcacc gtcaggaaga 79620
agaacaagaa aaactgttga taatttgtat gatataacaa atgctgatgg taattttttg 79680
gtagccggcg ataaaaagac taacgtcggt ggatcagaaa tttattacaa catggataat 79740
cgtctccacc aaatagatgg aagcaataca atatttgtgc gtggcgatga aactaagaca 79800
gttgaaggta atggaactat cctagtcaaa ggtaatgtta ctattgtagt cgaaggtaat 79860
gctgacatta cagttaaagg tgatgctact actttagttg aaggaaatca aactaacaca 79920
gtaaatggaa atctttcttg gaaagttgct gggacggttg actgggacgt tggtggtgat 79980
tggacagaaa aaatggcatc tatgagttct atttcatccg gtcaatacac aattgatgga 80040
tcgaggattg acattggcta atatacttcc aatgagcgct gatttaggag aatccatgga 80100
aggttcttct atcgacgtca cctttaccgc tcaattagaa acaggtgaaa cgttagtatc 80160
tataaatata actagttacg aagaaactcc tggggtttta gtagaagaaa atcgtttata 80220
tggaacgtat gaatctgtgt ttggatttgg aaatgatgcg ttgaaatatc gtttagataa 80280
tgaatttaaa accgctgctt catgggaaga ccttccaact gattctaata ctcagttata 80340
tttatggaaa gctcctcaaa acctccagaa gacattcact tacgaagtaa cattaatata 80400
tgactaccaa gaacaaagtg aatccggagg ttctggcagt aattctaggt catcttctga 80460
tactactgaa ccgacgaatc ctccagctcc aataagaaaa actcttgtta aaaattacac 80520
aaaaactata gttggaaatt ggagtcgttg ggctaataaa ttgagaagct atgtgtatga 80580
gaggccataa atgtcaggat taagttatga taagtgtgtt actgccggcc atgaagcgtg 80640
gcctccaaca gttgtaaatg ctacacaaag taaagtattc actggaggaa ttgctgttct 80700
cgtagcaggt gatccaatta cagaacatac agaaattaaa aggccatatg aaacacatgg 80760
cggagtgaca caacctagaa cttctaaggt atatgtcact ggaaagaaag ctgttcaaat 80820
ggctgatcca atatcatgcg gtgatactgt ggctcaggca tcatctaaag tattcattaa 80880
ataggattta aaatggcaaa tacccctgta aattatcaat taacaagaac agcaaatgct 80940
attcccgaga tattcgtcgg gggtacattt gctgaaataa aacaaaacct cattgaatgg 81000
cttaatggtc aaaatgaatt tttggattat gattttgaag gctcaagatt aaacgttctg 81060
tgcgaccttt tggcttataa tacattatac attcagcagt ttggtaatgc tgctgtatat 81120
gaaagcttta tgcgtactgc taacttacgt agttcagtag ttcaagctgc acaagataat 81180
ggatatttac ctacttcaaa atcagctgct caaactgaaa ttatgctaac ttgtacagat 81240
gcattgaata gaaattacat tactattcct cgcggtactc gctttttagc atatgcaaag 81300
gatacttctg ttaatcctta taactttgta tctaccgaag atgttattgc tattcgcgat 81360
aaaaataacc agtattttcc gcgtttaaaa ttagcccagg gacgtatagt aagaactgaa 81420
atcatttatg acaaattaac acctattatc atttatgaca aaaatataga tagaaaccaa 81480
gttaaactat acgttgatgg agcagaatgg attaactgga caagaaagtc aatggttcat 81540
gctggttcta catcaacaat ttactacatg cgtgaaacta ttgatggaaa tactgagttt 81600
tattttggtg aaggtgagat ttctgttaat gcggcagaag gagcattaac tgctaattac 81660
attggaggtc ttaaacctac ccagaactct acgattgtta ttgagtacat cagtactaac 81720
ggtgcagatg cgaatggcgc agtcggattt tcatatgcag atacattaac aaatataact 81780
gtcatcaaca ttaatgaaaa tccaaacgat gacccagatt ttgttggggc agatggcggc 81840
ggtgatccag aagatattga gcgtattcgc gaattgggta ctattaaacg cgaaacccag 81900
caacgctgcg taactgcgac tgactatgat acattcgttt cagagagatt tggttctatt 81960
attcaagcag ttcagacttt cactgattct actaaacctg gttatgcatt tattgctgct 82020
aaacctaaat cagggctata tttaactact gtacagcgcg aagatattaa aaattatctc 82080
aaagactata atttagctcc tattacgcca tcaattattt ctcctaatta tctttttatt 82140
aagactaatt taaaagtcac atatgcttta aataagctgc aagaatccga acagtggctc 82200
gaaggtcaaa taattgataa aattgatcgt tattataccg aagacgtaga aatttttaac 82260
tcatctttcg ctaaatctaa gatgttgaca tatgtagatg atgcagatca ttctatcatt 82320
ggctcatcag cgacaattca aatagtacgt gaagtacaaa acttctataa aacacctgaa 82380
gcaggtatta aatacaataa tcaaataaaa gatcgttcta tggaatctaa tacgttttca 82440
tttaattccg gacgaaaggt tgtaaatcct gatactggtt tagaagaaga tgtactatat 82500
gacgttcgta tagtatcaac agaccgagat tctaaaggaa ttggtaaagt tattattggt 82560
ccatttgctt ctggcgatgt tacagaaaat gaaaacattc agccatatac aggcaacgat 82620
tttaacaaat tagcaaattc tgatggacgc gacaaatact atgttatcgg tgaaataaat 82680
tatccagctg atgtgattta ctggaatatc gctaaaatta atttaacatc tgaaaaattt 82740
gaagttcaga ctattgaatt atattctgac ccaaccgatg atgttatctt tactcgcgat 82800
ggttcactga ttgtatttga aaatgactta cgtccacaat acttaactat cgatttggag 82860
cctatatcac aatgacagta aaagcacctt cagtcactag tctcagaatt tccaagttat 82920
ccgcaaatca ggtgcaagta cgctgggatg acgttggtgc taatttctac tattttgtag 82980
aaatcgctga gacaaaaaca aactcggggg aaaatctccc gagtaatcaa tatagatgga 83040
ttaacttagg atatactgca aataatagct tcttttttga tgatgctgac ccattgacat 83100
catacgttat tagagtagct acagctgcgc aagattttga gcagtctgat tggatttata 83160
ccgaagagtt tgaaactttt gctacaaatg cttatacatt tcaaaacatg attgaaatgc 83220
aattagctaa taaattcatt caggaaaaat ttactcttaa taattctgat tacgttaatt 83280
ttaataatga cactataatg gctgcattga tgaatgaatc attccaattc agcccgtcat 83340
atgttgacgt ttcatcaata agtaatttta ttattggtga aaatgagtat catgaaatac 83400
aaggttctat tcagcaagta tgtaaggata ttaaccgagt ttatttgatg gaatcagaag 83460
ggattttata cctttttgag cgttatcaac ctgtagttaa agtatccaat gataaaggac 83520
aaacttggaa agctgtaaag ctcttcaatg accgcgtagg atatccttta tctaagacag 83580
tatattacca atctgcgaac acaacatacg ttctaggata cgacaagatt ttctatggcc 83640
gcaaatcgac tgatgttaga tggtcagctg acgatgtcag atttagttct caggatataa 83700
cattcgctaa acttggcgac caattacatc taggatttga tgtagaaatt tttgccactt 83760
acgcaacttt gccagcgaat gtatatcgca ttgcagaagc tattacttgc accgatgatt 83820
acatttacgt tgtcgccaga gacaaagtta gatacataaa aacgagtaat gcacctatag 83880
attctgatcc attatctccg acatattcgg aaagactttt tgaacctgat actatgacta 83940
taaccggaaa tcctaaagca gtatgctata aaatggattc tgtcggtgat aaagtttttg 84000
ctcttattat tggtgaagtt gaaacattaa atgctaatcc tagaacatca aaaataattg 84060
attctgctga taaaggaata tatgttttaa atcatgacac aaaaacgtgg aaaagagttt 84120
ttggcaacac tgaagaagaa agaagacgta ttcaaccagg gtatgcgaat atgtcaactg 84180
atggtaaatt agtttctcta tcatcgagta attttaaatt tttaagcgat aatgttgtta 84240
atgaccctga aactgcagca aaatatcagt taatcggtgc tgttaaatat gaatttcctc 84300
gtgaatggtt agctgataag cattatcata tgatggcatt tatagcagat gaaaagtctg 84360
attgggaaac ttttactcct cagccgatga aatactatgc agaaccattc tttaactggt 84420
ctaaaaaatc taacacacgt tgttggataa acaactctga tagggttgta gtagtttatg 84480
ctgatttaaa atacactaaa gttatagaaa atattccgga aacatcacca gatagattag 84540
ttcatgaata ttgggacgat ggcgattgca ctatagtaat gccaaatgtt aaattcactg 84600
gatttaaaaa atatgcatct gggatgcttt tctataaagc ctctggcgaa ataatttctt 84660
actatgattt taactatcgt gctagagaca ctgtcgaaat tatttggaag ccaactgaag 84720
tatttttaaa agcattttta caaaaccaag agcatgaaac tccttggtcg cccgaagaag 84780
agcgtggatt agctgaccct gatttaagac cattgattgg cacaatgatg cctgattctt 84840
atttgttaca ggattcgaat tttgaggcat tttgcgaagc atatattcag tatctttctg 84900
atggatatgg aacccagtat aataatttac gaaatttaat tcgtaacaaa tatccacgag 84960
aagagcatgc atgggaatat ttgtggtcag agatatataa aagaaacatt tatttaaatg 85020
ctgacaaacg tgatgctgtt gcaagatttt tcgaatcacg tagctatgat ttttattcta 85080
ctaaaggaat tgaagcatca tacaaatttc tttttaaagt tctttataat gaagaggttg 85140
aaattgaaat tgaatctggg gctggtactg aatatgatat aatcgttcaa tctgattctt 85200
tgactgaaga cttagtagga caaacgattt atacagctac aggaagatgt aatgttactt 85260
atatagaaag aagctattct aatggtaaat tgcaatggac cgtaactatt cataatcttt 85320
taggaagatt aattgccggt caagaagtta aagcagaaag actccctagt tttgaaggcg 85380
aaattattcg cggggttaaa ggaaaggatt tgcttcaaaa taatatagac tatattaata 85440
gaagtcggtc atattatgta atgaaaatta aatccaattt gccttcttcc cgctggaaat 85500
ctgacgttat tcgttttgtt cacccagtag gatttggatt tatagcaatt actcttttaa 85560
caatgtttat taatgttggt ttaactctta aacacacaga gactataatt aataaataca 85620
aaaactacaa atgggattct ggattgccta ctgaatatgc tgatagagta gctaaattaa 85680
ctccgactgg tgaaattgag catgattcgg taacaggcga agcaatttat gagcctggcc 85740
caatggctgg cgtagaatat cctcttcctg atgactataa tgctgaaaat aacaattcaa 85800
tatttcaagg tcaattgccg tctgaacgac gtaaattaat gagtccttta ttcgatgcat 85860
ctggaacaac atttgcacaa tttagggatt tagttaataa acgtctaaaa gataatatag 85920
gaaatccaag agaccctgaa aatccaacac aggttaaaat agatgaatga ttcaagtgtt 85980
atctatcgtg cgatagttac ttcaaaattt agaacagaaa aaatgttgaa tttttataat 86040
tcaattggaa gtggtccgga taaaaacact atctttatca catttggaag atcagaacca 86100
tggtcatcaa atgaaaatga ggtgggcttt gctccacctt atccaactga ttctgtatta 86160
ggtgtaactg acatgtggac tcatatgatg ggaactgtaa aggttcttcc atctatgctt 86220
gatgcagtta ttcctcgtag agattgggga gatactagat atcctgatcc atacacattt 86280
agaattaacg atattgtagt gtgtaactca gctccttaca atgctactga atcaggcgca 86340
ggctggttag tatatcgctg tttagatgtt cctgatactg gaatgtgctc aattgagtct 86400
ttaactaata aggatgaatg ccttaagtta ggtggaaaat ggactccttc tgctaggtca 86460
atgactcctc ctgaaggtcg aggagacgcg gaaggaacaa tcgaacctgg agacgggtat 86520
gtatgggaat atctttttga gattccgcct gatgtatcta taaatagatg tacgaatgaa 86580
tatatcgtgg ttccttggcc ggaagaatta aaagaagacc cgactagatg ggggtatgaa 86640
gataatctca cttggcaaca agatgatttt ggattaattt atcgtgttaa ggcaaatact 86700
atccgtttta aagcatattt agattcagtt tattttcctg aagctgcact gccgggaaat 86760
aaaggattta gacaaatatc aataatcacg aatcctcttg aagctaaagc tcatccaaat 86820
gacccaaacg ttaaagctga aaaggattat tatgatccgg aagatttaat gaggcattcg 86880
ggcgaaatga tttatatgga aaataggcca cctattatta tggcaatgga tcaaacagaa 86940
gaaatcaata ttctgtttac attttaactt aagggagccc atgggctccc tttttcttta 87000
taaatactat aaactcataa ggaaaccgct atgttcattc aagaaccaaa gaaattgatt 87060
gataccggcg aaattggtaa cgcttctact ggtgatatct tattcgacgg tggtaataaa 87120
attaatagtg attttaacgc aatttataat gcgtttggcg atcaacgtaa aatggcagta 87180
gcaaatggaa ctggagcaga tggccaaatt atccatgcta ctggatatta tcaaaaacac 87240
tctatcgcag agtacgcaac tccagtaaaa gttggcacta gacatgatat tgatacctct 87300
actgtaggtg ttaaagttat cattgaaaga ggcgaacttg gcgactgtgt tgaatttatt 87360
aactcaaatg gatcaatatc agttactaat cctttaacga ttcaagcgat tgattcaatt 87420
aaaggtgttt caggtaattt agtagtaact agcccatata gtaaagtaac tttacgttgt 87480
atttcatctg ataattctac atcggtgtgg aattattcta ttgaaagtat gtttgggcaa 87540
aaggaatcac cagctgaagg tacatggaat atttctacat ccggatcagt tgatattcca 87600
ctatttcatc gcactgaata caatatggct aaattgttag ttacatgcca atcagtagat 87660
ggaagaaaaa ttaaaacagc agaaataaat attcttgtgg atactgttaa ttcagaggta 87720
atttcttctg aatatgctgt catgcgagtt ggtaatgaaa ccgaagaaga cgaaatcgct 87780
aatattgcat ttagtattaa agaaaattat gtaacggcga ctataagttc ttcaactgtc 87840
ggtatgagag cagcagttaa agttatcgct acgcagaaaa tcggggtggc tcaataatga 87900
aacaaaatat taatatcggt aatgttgttg atgatggtac cggtgactac ctgcgtaaag 87960
gtggtataaa aataaatgaa aactttgatg agctttatta cgagcttggt gatggagatg 88020
ttccatattc agccggtgcc tggaaaactt atgatgcttc atctggtcaa acactaaaag 88080
ccgaatgggg aaaatcatac gctattaata cctcttctgg aagagtgact ataaatcttc 88140
caaaaggaac tgtcaatgat tacaacaagg taattagagc tagagacgta tttgctacat 88200
ggaacgtcaa cccagttaca ctagtagctg cttccggcga tacgattaaa gggtctgcag 88260
taccagttga aattaatgtt caattcagtg atttagaact agtgtattgc gccccaggac 88320
gttgggaata tgtcaaaaat aagcaaattg acaaaattac tagttcagac attagtaatg 88380
tagctcgtaa agaattttta gtcgaagtcc aaggacaaac agacttttta gatgttttcc 88440
gtggaactag ttataatgta aataacatca gagtaaaaca tcgtggtaac gaattgtatt 88500
acggcgatgt atttagtgaa aacagtgatt ttggctctcc gggtgaaaat gaaggtgaat 88560
tagttcctct tgatggattt aatattcgat taagacagcc ttgtaatatt ggtgacactg 88620
ttcaaatcga aacatttatg gatggtgtat cgcagtggag aagttcatat acaagacgtc 88680
aaattagatt gttagattca aaattaacgt caaaaacttc tttagaagga agcatttacg 88740
ttactgattt atcaacaatg aaatcaattc cattttcagc ttttggatta attccaggtg 88800
aacctattaa tcctaattct cttgaggttc gttttaatgg aattttacaa gaattggctg 88860
gaacagttgg aatgccatta tttcattgtg ttggtgctga ttcagacgat gaagtagaat 88920
gctctgtttt aggtggaact tgggaacagt ctcataccga ctattcagtt gaaactgatg 88980
aaaacggcat accggaaatt ttacatttcg atagagtatt tgagcatggc gacattatca 89040
atatcacctg gtttaataat gatttaggta cattattaac aaaagacgag attattgatg 89100
aaactgataa tctctatgta tcgcaaggac caggagtaga tatttccggt gatgtaaatt 89160
taacagactt cgataaaatt ggttggccaa atgtagaagc agttcaatcc tatcaacgtg 89220
aatttaatgc tgtttcaaat atctttgata cgatttatcc tattggaact atatatgaaa 89280
acgctgttaa tccaaataac cctgttacat atatgggatt cggctcatgg aaattatttg 89340
ggcaaggaaa agttttagtt ggatggaatg aagatatttc ggaccctaac tttgctctaa 89400
ataacaacga tttagattcg ggtggaaatc cttcacatac tgcaggtgga acaggtggtt 89460
ctacttctgt tacattggaa aatgctaatc ttcctgcaac cgaaacagat gaagaagttc 89520
taatagttga tgaaaatgga tcagtcattg ttggtggatg tcaatacgat ccagatgaat 89580
ccggtccagt ttacacgaaa taccgtgaag ctaaagcatc tactaactct actcacactc 89640
cgccaacatc aataactaac attcaaccat atattacagt ttatcgttgg ataaggattg 89700
cataatgagt ttacttaata ataaagcggg agttatttcc cgcttagccg attttcttgg 89760
ttttagacct aaaactggcg acatcgatgt aatgaatcgt caatcagttg ggtcagtgac 89820
aatttctcaa ttagcgaaag gattttatga accaaacata gaatcagcta ttaatgatgt 89880
tcataatttt tctataaaag acgttggtac aattattact aataaaactg gtgtttctcc 89940
tgagggtgtt tctcaaactg attattgggc attttcagga actgtgacag atgattcgct 90000
tcctcctggt tctcctgtta ctgtattagt atttggtctt ccagtttcag caacaactgg 90060
aatgacagct attgagtttg tcgccaaagt tcgtgttgca ctgcaagaag ctattgcgtc 90120
atttactgct atcaattcat ataaagacca tccaaccgat ggtagtaaat tagaagttac 90180
ttatttagat aatcagaaac atgtattaag cacatattct acatatggaa taactatttc 90240
ccaagaaatt atttccgaat ctaagcctgg atatggcaca tggaatttgc ttggtgcaca 90300
aactgtaact ttagataatc agcaaactcc aatagtactt tatcattttg agagaacagc 90360
atgagtaata atacatatca acacgtttct aatgaatctc gctatgtaaa atttgatcca 90420
actggtacaa attttccagc agagattact gatgttcagg ctgctatagc agccatttct 90480
cctgctggtg taaatggagt tcctgacgca tcatcaacaa caaagggaat tttatttctt 90540
gccactgaac aggaagttat cgacggaact gataatacca aagcagttac accagcaacg 90600
ttagcaacaa gattatctta tccaaacgca actgaaactg tttacggatt aacaagatat 90660
tcaaccaatg atgaagcgat tgccggagtt aataatgaat cttctataac tcccgctaaa 90720
tttaccgttg cccttaataa tgcctttgaa acacgagttt caactgaatc atcaaatgga 90780
gttattaaaa tttcatctct accgcaagca ttagctggcg cagatgatac tactgcgatg 90840
actccattaa aaacgcagca gttagctatt aaattaattg cgcaaatcgc tccttctgaa 90900
accacagcta ccgaatcgga ccaaggtgtt gttcaattag cgacagtagc tcaagttcgt 90960
caaggaacct taagagaagg ctatgcaatt tctccttata cgttcatgaa ttctattgct 91020
actgaagaat ataaaggcgt aattaaatta ggaacacaat cagaagttaa ctcgaataat 91080
gcttctgttg cggttactgg cgcaactctt aatggtcgtg gttctacaac gtcaatgaga 91140
ggcgtagtta aattaactac aactgccggc tcacagagtg gaggcgatgc ttcatcagca 91200
ctagcttgga atgctgacgt tatccatcaa agaggtggtc aaacgattaa tggaacactt 91260
cgcattaata atacgctcac aatagcttca ggcggagcaa atattaccgg aacagttaac 91320
atgaccggtg gttatattca gggtaagcgt gttgtaacac agaatgaaat agatagaact 91380
attcctgtcg gagctattat gatgtgggcg gcagatagtc ttcctagtga tgcttggcgc 91440
ttctgtcatg gcggaactgt ttcagcgtcg gattgcccat tatatgcttc tagaattgga 91500
acaagatacg gcggaagttc atcaaatcct ggattacctg atatgcgtgg cctttttgtt 91560
cgtggctctg gtcgtggctc tcacttaaca aatccaaatg ttaacggtaa tgaccaattt 91620
ggtaagccta gattaggtgt aggttgtacc ggtggatatg ttggcgaagt acaaaaacag 91680
cagatgtctt atcataaaca cgctggcgga tttggtgaat gggatgattc tggagcattc 91740
ggtaataccc gtagatcaaa ttttgttggt acacgtaaag gacttgactg ggataaccgt 91800
tcatacttca ccaatgatgg atatgaaatt gacccagcat cacaacgaaa ttctagatac 91860
acactaaatc gtcctgaatt aattggaaat gaaacacgtc catggaacat ttctttaaac 91920
tacataatta aggtaaaaga atgacagata ttgtactgaa tgacttacca ttcgttgacg 91980
gccctcctgc agagggccag agccgcattt cctggattaa aaacggcgaa gaaatattag 92040
gagctaacac acagtatgga agtgaaggct caatgaatag acctacagtt tctgtactaa 92100
gaaatgttga agttcttgat aaaaacattg gaatacttaa aacatcttta gaaaccgcaa 92160
atagtgatat taaaacaatt cagggcatct tagatgtatc tggtgatatt gaagctttgg 92220
cccaaatagg tatcaataaa aaggatattt ctgacctcaa aacgctaacc agtgaacata 92280
cagaaatatt aaatggaact aatagtacgg ttgacagtat tcttgctgat attggtccat 92340
ttaactctga ggccaactct gtatacagaa caatcagaaa tgatttacta tggataaagc 92400
gtgaacttgg acaatacaca ggtcaagata ttaatggtct tcctgttgta ggaaatccta 92460
gcacaggaat gaagcatcgc attattaata atactgatgt catcacttca cagggaatac 92520
gtttaagcga attagaaaca aaatttattg aatctgatgt aggttctttg actattgaag 92580
ttggtaatct tcgtgaagag cttggaccaa aaccaccatc attttcacaa actgtttaca 92640
gtcgtttaaa tgaaattgac actaaacaga caacagttga gtctgacatt agtgctatta 92700
agacctcaat aggatatcca ggaaatactt cgattatcac gaatgttaat acaaacactg 92760
ataatattgc atctattaat ttagagctaa atcaaagtgg aggtattaaa caacgtttaa 92820
ccgttattga aacttctatt ggttcagatg atattccttc gagtattaaa ggccaaatca 92880
aagataatac aacttcaatt gaagctctaa atggaatcgt cggtgaaaac acctcatctg 92940
gtttaagagc gaatgtttcg tggttaaacc aaattgttgg aactgattct agcggtggac 93000
aaccttctcc tcctgggtct cttttaaacc gagtttctac aattgaaact tctgtttcaa 93060
gcttgaacaa cgatgttcag aacctacaag tagagattgg taataacagc acaggaatta 93120
aagggcaagt tgtagcgtta aatactttag taaatggaac taatccaaac ggttcaactg 93180
tcgaagaacg tggattaacc aattcaataa aagctaacga aaccaacatt gcatcagtta 93240
cacaagaagt gaatacagcc aaaggtagta tatcttctct gcaaggtgat gttcaagctc 93300
tacaagaagc aggttatatt cctgaagctc caaaagatgg tcaagcttac gttcgtaaag 93360
acggcgaatg ggtattactt tctacctttt tatcaccagc ataacatggg gccgcaaggc 93420
cccaaaggat ttttaaatgt caggatataa ttctcagaat ccaaaggaac tcaaagatgt 93480
cattctaaga cgtttagggg ctccaattat taatgttgag ttaacacccg atcaaatcta 93540
cgattgcatc cagcgtgccc tagaattata cggtgaatac cattttgatg gacttaacaa 93600
aggttttcat gtattttatg taggagatga cgaggaaaaa tataaaaccg gagtcttcga 93660
tttaagaggt tcaaatgtat tcgcagtaac tcgcattctc cgcacgaatg ttggatcaat 93720
aacgtcaatg gacggaaacg ctacatatcc atggtttact gactttcttt tgggaatggc 93780
tggtattaat ggtggcatgg ggacttcttg taatagattt tatggaccaa atgcctttgg 93840
agctgattta gggtatttta cccagcttac cagttacatg ggaatgatgc aagatatgct 93900
ttcgcctatt ccagactttt ggtttaattc agcaaatgaa cagctcaaag tcatgggaaa 93960
cttccaaaaa tatgatttaa ttattgtaga aagctggact aaatcatata ttgatactaa 94020
taaaatggtt ggaaatacag taggatatgg aacagtcggt ccacaagata gctggtcatt 94080
atctgaacgg tataataacc cagaccacaa tttagttggt cgcgttgttg gtcaagatcc 94140
aaatgttaag caaggcgctt ataataatcg ttgggtgaaa gactatgcta cagctttagc 94200
taaagaatta aatggccaaa ttttagcacg tcaccaaggc atgatgcttc ctggcggtgt 94260
tacaattgat ggacagcgct taatagaaga agctcgatta gaaaaagaaa cattgcgcga 94320
agaattatac ttgctcgatc ctccatttgg aattttggta ggttaatatg gctacttatg 94380
ataaaaatct ttttgctaaa ttagaaaatc gcactggtta ttctcagact aatgaaactg 94440
aaatactaaa tccttatgta aatttcaatc attataaaaa cagccaaata ttagctgatg 94500
tattagtggc tgaaagcatt caaatgcgag gtgtagaatg ctattatgtt ccaagagagt 94560
atgtttcccc tgatttgata tttggcgaag acttaaaaaa taaatttact aaagcttgga 94620
aattcgctgc atatttaaat tcattcgaag gatatgaagg agctaaatcg ttctttagta 94680
attttggtat gcaagtacag gatgaagtta ctttgtcaat taatccaaac ttgtttaaac 94740
accaagtaaa tggaaaagaa cctaaggaag gcgatttgat atattttcct atggataaca 94800
gcttattcga aattaactgg gttgaaccat atgatccatt ttatcaatta ggccaaaatg 94860
ctattcgtaa aattacggca ggtaagttca tttattccgg tgaagaaatt aatccagttc 94920
tacagaaaaa tgaaggaatt aacattccag aatttagtga attagaatta aatcctgttc 94980
gcaatcttaa tggcattcat gatattaata ttgatcagta tgctgaagta gatcaaatta 95040
attctgaagc taaagaatat gttgaacctt atgttgttgt caataacaga ggcaaatctt 95100
ttgaatctag cccatttgat aatgatttca tggattaata aatattataa actaattaaa 95160
gcccagatta ggagaaatca tgtttggtta tttttataat tcgtctttta gacgatatgc 95220
taccttgatg ggcgatttgt tttcaaatat ccaaatcaaa cgtcagttag aatctggtga 95280
taagtttata cgtgttccta ttacgtatgc atcaaaggaa cacttcatga tgaaattaaa 95340
taaatggaca tcgataaatt cacaggaaga tgtagctaaa gttgaaacta ttctacctcg 95400
tataaattta catttagttg attttagcta taatgctcca tttaaaacaa acattttaaa 95460
tcagaattta ctgcaaaaag gcgcaacttc tgtagtatca cagtataatc catctcctat 95520
taaaatgatt tatgaattga gtatctttac tcgctacgaa gatgatatgt ttcaaatagt 95580
tgaacagatt cttccatatt ttcaacctca ttttaataca actatgtacg aacagtttgg 95640
aaatgatatt ccatttaaaa gggatattaa aattgtactg atgtctgctg ctatagacga 95700
atctatagat ggagataatt tatctcgtcg tagaattgaa tggtcactaa catttgaagt 95760
aaacggatgg atgtatcctc cggtagatga tgcagaagga ttaattcgta ctacttatac 95820
agattttcac gccaatacaa gagatttgcc tgacggcgaa ggtgtttttg aatctgtcga 95880
tagcgaagtt gttcctcgag atattaaccc agaagactgg gatggaacag taaaacaaac 95940
tttcactagc aatgtaaata gaccaacacc gccagaacct cctggcccaa gaacatagag 96000
gttattatgg aaggtcttga tataaacaaa cttttagata tttctgacct ccccggaatt 96060
gacggggagg aaattaaagt atatgaacct ctgcaattag tagaagttaa aagcaatcct 96120
caaaaccgta ctcctgactt agaagatgat tatggagtag ttcgtcgaaa tatgcatttt 96180
caacagcaaa tgctaatgga cgcagccaag atttttcttg agacagcaaa gaatgctgat 96240
tctcctcgtc acatggaagt atttgcaact cttatggggc aaatgactac gacgaataga 96300
gaaatactga agcttcataa agatatgaaa gatattacgt ctgagcaggt tggcactaaa 96360
ggtgctgttc ctaccggtca aatgaatatt caaaatgcga cagtattcat gggttcacca 96420
acagaattaa tggacgaaat tggtgatgct tacgaggctc aagaagctcg tgagaaggtg 96480
ataaatggaa caaccgatta atgcattaaa tgatttccac ccgttaaatg aagctggaaa 96540
aattttaata aaacacccga gcttagcgga aagaaaagat gaagatggaa ttcattggat 96600
aaaatcacag tgggatggaa aatggtatcc tgaaaaattc agtgattatc ttcgtctaca 96660
caaaatagta aaaattccaa ataattctga taagcctgaa ttatttcaaa cttataaaga 96720
taagaataat aaaagatctc ggtatatggg tcttcctaac ttgaaacgag ctaatattaa 96780
aacacaatgg actcgtgaaa tggttgagga gtggaaaaaa tgccgagacg atattgttta 96840
ttttgcagaa acatactgcg ccattacaca tattgactat ggtgtcataa aggttcaatt 96900
acgtgactat cagcgtgata tgctcaaaat aatgtcatct aaacgtatga ctgtttgtaa 96960
tttatcacgc cagcttggta aaacaactgt agtagctatt tttcttgcac actttgtatg 97020
ttttaacaag gataaagctg taggtattct tgctcacaaa ggctcaatgt ctgcggaagt 97080
tttagatcgt actaagcaag caattgaact gcttcctgac tttttgcagc caggaattgt 97140
tgaatggaat aaaggatcta ttgaacttga taatggttcc tcaatcggag cctatgcttc 97200
ctctcctgac gcagttcgtg gtaactcgtt cgcaatgatt tatattgacg aatgcgcatt 97260
tattccaaac ttccatgatt cctggcttgc tattcaaccg gtaatttcat ctggtcgtcg 97320
ttcgaaaatt attattacta cgactcctaa tggattaaat catttttatg atatttggac 97380
tgctgccgtt gaaggtaaat cagggtttga accatacact gctatttgga attcagttaa 97440
agaacgtctt tataacgatg aagatatttt tgacgatgga tggcaatgga gcatacaaac 97500
cattaatggt tctactttag ctcaatttcg tcaagaacac actgcagcgt ttgaagggac 97560
ttctggtaca ttaatttcag gaatgaaatt ggctgttatg gatttcattg aagtaactcc 97620
agatgatcat ggttttcatc gatttaaaag ccctgaacca gatagaaaat atattgcaac 97680
tctagactgt tcagaaggtc gtgggcaaga ttatcacgct ttacatatta ttgatgttac 97740
tgatgatgtg tgggagcagg ttggtgtttt acactcaaac actatttctc atttaattct 97800
acctgacatc gttatgcgtt atttagtaga atataatgaa tgcccagttt atattgaatt 97860
aaatagtact ggtgtgtcag ttgcgaaatc actttacatg gatttagaat acgaaggcgt 97920
tatttgcgat tcatatactg atttaggaat gaaacagaca aaacgtacta aagcagtggg 97980
atgctctaca ttaaaagacc ttattgaaaa agataagctt attattcatc accgcgcaac 98040
tattcaagag tttagaacgt ttagtgaaaa aggcgtgtct tgggcggctg aagaaggtta 98100
tcacgacgat ttagtaatgt ctttagtaat ttttggatgg ttatcaacac aatcaaaatt 98160
tattgattat gctgacaaag atgacatgcg actagcatct gaagtgtttt caaaagagct 98220
tcaagatatg ggcgatgaat acgctccagt tatatttgtt gattcggttc attctgctga 98280
gtatgttcca gtatctcatg gtatgtcaat ggtataaata tattaaagca tattaaagag 98340
gattaaaaat gactttatta tctccgggca ttgagctcaa agaaactacg gttcaaagca 98400
ccgtggttaa taactctact ggtacagcag ctctggccgg taaattccag tggggtcctg 98460
cttttcaaat taaacaggtt acaaatgaag tagatttagt taatactttt ggtcaaccta 98520
cagctgaaac tgctgactat tttatgtctg caatgaattt cttacaatac ggaaatgatt 98580
tgcgagttgt gcgtgctgtc gatagagata ccgctaaaaa ctcatctccg attgccggta 98640
atattgaata cactatttct accccaggta gtaactacgc ggttggagat aaaatcacgg 98700
ttaagtatgt ttcagaagac attgaaacag aatgtaaagt taccgaagta gatgctgatg 98760
gaaaaattaa gaaaattaat attcctactg caaaaattat cgctaaagcg aaagaagtag 98820
gcgaatatcc agaattaggt tctaactgga ccgcggaaat ttcttcgtct tcctctggtt 98880
tagctgcagt aataactctt ggaaaaatta ttactgattc tggtatttta ttagctgaaa 98940
ttgaaaatgc cgaagctgct atgacagctg ttgactttca agcaaatctc gaaaaatatg 99000
gaattccagg agtagtagct ctttatccag gcgagttggg cgataaaatc gaaattgaaa 99060
tcgtatctaa agctgactac gcaaaaggtg cttctgcatt actcccaatt tatccaggtg 99120
gcggaacacg cgcatctact gccaaagcag tgtttggata tggaccacaa actgattcac 99180
aatacgctat tatagttcgt cgcaatgatg ctattgttca aagcgttgtt ctttcaacga 99240
agcgtggtga aaaagatatt tacgatagta acatctatat tgatgacttt ttcgcaaaag 99300
gtggttcaga atatattttc gcaactgcac aaaactggcc agaaggcttc tctggaattt 99360
taactctgtc tggtggatta tcatcaaatg ctgaagtaac agcaggagat ttgatggaag 99420
cctgggactt ctttgctgac cgtgaatctg ttgacgttca gttgtttatt gcgggttctt 99480
gtgccggtga atctttagaa acagcatcta ctgtccaaaa acacgtcgtt tcaattggag 99540
atgctcgcca agattgctta gtattgtgct caccaccgcg tgaaactgtt gttggaattc 99600
ctgtaactcg tgctgtcgat aacttagtca attggagaac tgcaactggt tcatacactg 99660
ataataactt taatatcagt tcaacctacg cagcaattga tggtaactac aagtatcagt 99720
atgacaaata taatgatgtg aatcgttggg ttccattagc agctgatatt gctggtttat 99780
gcgcaagaac tgataacgtt tctcagactt ggatgtctcc agctggttat aatcgtggtc 99840
agattcttaa cgttattaaa cttgctattg aaactcgtca ggctcagcgc gaccgtttat 99900
atcaagaagc tatcaaccca gtaactggta caggtggtga tggttacgta ttgtatggtg 99960
ataaaacagc tacttctgtt ccttctccat ttgatcgtat taacgttcgt cgtctgttta 100020
atatgttgaa aacgaatatc ggacgtagtt caaaatatcg tttgttcgaa ttaaacaacg 100080
cgtttactcg ttcatcgttc cgcacagaaa cttcccagta cttgcaggga attaaagctc 100140
tcggtggaat ttatgaatat cgtgtagttt gcgatacaac aaataacact ccgtcagtaa 100200
ttgatagaaa tgagtttgtt gcaacattct acattcaacc ggctagaagc attaactaca 100260
ttaccttaaa cttcgtagca actgctactg gtgcagattt cgatgagtta actggtcttg 100320
caggttaata cggtgcattc taaaggcctg tttcggcagg ccatataaat acactatatc 100380
cttaattctt taattctata tgccctaggt taaacatagg gatataaata ctacagaggc 100440
taatatgttt gtagatgatg taacacgagc gtttgaatct ggtgattttg ctcgacctaa 100500
cttattccaa gtagaaattt cttatcttgg acaaaatttt acgtttcaat gtaaagccac 100560
tgctttacca gctggtattg tagaaaaaat tccagtcgga tttatgaacc gtaaaattaa 100620
cgtagcaggc gatcgtacat tcgatgactg gactattaca gtaatgaatg acgaggcgca 100680
tgatgcacgt cagaagtttg ttgactggca aagcattgct gctgggcaag gaaatgaaat 100740
tactggtgga aaaccggcag agtataaaaa gagtgctatt gtacgccaat acgctcgtga 100800
cgctaaaact gtaacaaaag aagtcgaaat taaaggcctg tggcctacta acgtgggtga 100860
acttcaatta gattgggatt caaacaatga aatccaaacc tttgaagtaa ctctcgctct 100920
cgattattgg gaataaaatg aatggggaga aatccccatc ctgcttaaag cagagaagtc 100980
cattataaat ataactataa ttcccatttg gagaatacaa tgaaatttaa tgtattaagt 101040
ttgtttgctc catgggctaa aatggacgaa cgaaatttta aagaccaaga aaaagaagat 101100
cttgtttcca ttacagcccc aaagcttgat gatggagcaa gagaatttga agtaagctcg 101160
aatgaagctg cttctcctta taatgctgca ttccaaacaa tttttggttc atatgaacca 101220
ggaatgaaaa ctactcgtga gcttattgat acatatcgta atctcatgaa taactatgaa 101280
gtagataatg cagtttcaga aatcgtttca gatgctatcg tctatgaaga tgatactgaa 101340
gtcgtagcgt taaatttgga taaatctaaa tttagcccaa aaattaaaaa tatgatgtta 101400
gatgaattta gcgatgtatt aaatcatcta tcgtttcaac gaaaaggttc tgatcatttt 101460
agacgttggt atgtcgattc gagaattttc tttcataaaa ttattgaccc aaaacgtcca 101520
aaagaaggca taaaggaatt acgtagatta gaccctcgcc aagttcagta tgttcgtgaa 101580
attataacag aaactgaagc tggcacaaaa atagttaaag gttacaaaga atattttata 101640
tatgatactg cacatgaatc atatgcatgt gatggtagaa tgtatgaagc tggcacaaaa 101700
ataaaaattc ctaaagctgc cgtcgtttat gcccattctg gattagttga ttgttgtggt 101760
aaaaatatca tcgggtattt gcatcgtgct gttaaacctg ctaaccaatt aaaattatta 101820
gaagatgccg tagtcattta tcgtattact cgcgctcctg accgtcgtgt ttggtatgta 101880
gacacaggta atatgcctgc tcgtaaagct gccgagcaca tgcaacatgt tatgaacacg 101940
atgaaaaacc gtgtagtata tgacgcatcg acaggtaaaa taaaaaatca acagcataat 102000
atgtctatga ccgaagacta ttggttgcag cgccgtgatg gtaaagctgt gacagaagtt 102060
gatactcttc ctggtgctga taataccggt aatatggaag atgttcgttg gtttagacaa 102120
gctctttata tggcattacg tgttcctctt tcacgcattc cgcaagacca acaaggcggt 102180
gtgatgtttg attctggaac tagcattaca cgtgatgaat taacgtttgc taaatttatt 102240
cgtgagttac agcacaagtt tgaagaagtt ttcctagatc cgcttaaaac aaatcttttg 102300
cttaaaggca taatcacaga agatgagtgg aatgatgaaa taaataatat taagatagaa 102360
tttcatcggg atagctactt tactgaactc aaagaagcag aaattttgga acgaagaatt 102420
aatatgctaa ccatggcaga accatttatt ggtaaatata tttctcacag aactgctatg 102480
aaagatattt tgcagatgac tgatgaagaa atagaacaag aagccaagca aattgaagaa 102540
gagtctaaag aggctcgttt ccaagacccc gaccaagaac aagaggattt ttaatggaag 102600
gtttaattga agctattaaa tcaaacgacc tcgtagccgc tcgtaaatta tttgctgaag 102660
ccatggctgc aagaacgatt gatttaatta aagaagaaaa aatcgctatc gctcgtaatt 102720
tcttaatcga aggtgaagaa cctgaagacg aggatgatga cgaagatagt gatgataaag 102780
acgacaaaaa agacaaagac tctgacgaag atgacgaaga cgaggatgat gaataatgct 102840
tctgatccct gaaactcatg aattagttct cgagaatgtc gaagcactta ttcctgaagc 102900
acagggtcgc tttgacgaat tgtcttctgc tttaaataaa gacgatataa atacaattgt 102960
cgagaatatg cttgatgatg aaactgattt agcagttgca ttagcttcta ttaatgaaaa 103020
tatgccgtta aatgaattca ttgttaagca tgtttctgct cgtggtgaaa ttacacgtac 103080
taaagaccgc aaaacgcgcg aacgtaatgc atttcaaacc actgggctgt ctaaagcaaa 103140
acgtagacaa attgctcgca aagctaccaa aacgaagatt gccaatccag caggtcaatc 103200
tcgtgctcag cgtaagcgta aaaaagctct taaacgccgt aaagcattag gattaagcta 103260
atgaatgaac cccaattact aattgaaact tggggtcaac ctggcgaaat tattgatggt 103320
gtgccaatgc ttgaatccca cgatggaaaa gacttaggtt taaaacctgg tttatacatc 103380
gaaggaatat tcatgcaagc agaagtcgtc aatagaaata aacgtcttta tccaaaacgc 103440
atattagaaa aagcggtaaa agactatatt aatgagcaag ttttaactaa acaagctctc 103500
ggagaattaa atcatcctcc acgcgctaat gttgacccga tgcaagccgc tatcattata 103560
gaagatatgt ggtggaaagg aaatgacgta tacggacgag ctcgtgttat tgaaggtgac 103620
cacggtcctg gagataaatt agcagctaat attcgtgccg gatggattcc aggagtttct 103680
tctcgtggat taggttcatt gactgacaca aataaaggtt atcgtatcgt aaacgaagga 103740
ttcaaattaa ctgtaggtgt tgatgcagta tggggtccaa gtgctccaga tgcatgggta 103800
actcctaagg aaattaccga atcacagacg gcggaagccg atacaagtgc cgatgacgcc 103860
tatatggctc tcgcagaggc catgaaaaaa gcgttataaa tattattatc taaacaacag 103920
gactacaaaa tgcttaaaga acaactgatt gctgaagcgc aaaaaattga tgcttccgtt 103980
gctcttgata gtattttcga atcagttaat atttctccgg aagcaaaaga aactttcggc 104040
actgtattcg aagctaccgt caagcagcac gccgttaaat tagctgaatc tcatatcgct 104100
aaaattgctg aaaaagcaga agaagaagta gaaaaaaata aagaagaagc cgaagaaaaa 104160
gctgagaaga aaatcgctga gcaagcttct aaattcattg accatcttgc gaaagaatgg 104220
ctcgctgaaa ataaattagc agttgataaa ggcatcaaag ccgaactgtt tgaatccatg 104280
cttggtggat taaaagagct ctttgttgaa cacaacgttg ttgttccaga agaatcagtt 104340
gatgttgtgg ctgaaatgga agaagagctg caagaacata aagaagaatc agctcgtctg 104400
ttcgaagaac tcaatatgcg cgacgcatat atcaattatg tgcagcgtga agtggcattg 104460
agcgaaagta ctaaagatct gactgagtct caaaaagaaa aagtctctgc tctggtcgaa 104520
ggtatggatt attcagatga attctcaaat aaattgagtg ccatcgtaga aatggtgaag 104580
aagtctaata aagatgaaag cactattact gagggtataa atactcctga tactgaagca 104640
gccggactga atttcgtcac tgaagctgta gaagataaag ctgcacctgg tgcagaagat 104700
attgtaagtg tatatgcgaa agtcgcatct cgtttctaat tttaaaggtt aacacaaatg 104760
actatcaaaa ctaaagctga acttttgaac aaatggaagc cattactgga aggtgaaggt 104820
ttaccggaaa ttgctaatag caaacaagcg attatcgcta aaatctttga aaaccaggaa 104880
aaagatttcc agacagctcc agagtacaaa gacgaaaaaa tcgctcaggc gttcggttct 104940
ttcttaacag aagctgaaat cggtggtgac cacggttaca atgctactaa catcgctgct 105000
ggtcagactt ctggcgcagt aactcagatt ggcccagctg ttatgggtat ggtacgtcgt 105060
gctattccta acctgattgc tttcgatatt tgcggtgttc agccgatgaa tagcccgacc 105120
ggtcaggtat tcgcactgcg tgctgtatat ggtaaagacc caatcgctgc cggtgctaaa 105180
gaagcattcc acccaatgta tggtccagat gcaatgttct ctggtcaggg tgctgctaag 105240
aaattcacag ctctggctgc tagcacacaa accacagtag gtgatatcta tactcacttc 105300
ttccaggaca ctggtactgt gtatctgcag gcttctgctc aagtaacaat tagttcaagt 105360
gctgatgatg cagctaaatt agatgctgaa attaagaaac aaatggaagc tggtgcactg 105420
gtagaaatcg ctgaaggtat ggctacttct atcgctgaac ttcaggaaag tttcaacggt 105480
tctaccgata acccatggaa tgaaatgggc ttccgtatcg ataaacaagt tatcgaagct 105540
aaatctcgcc agctgaaagc tgcttactct atcgaattag cacaagacct ccgcgctgtt 105600
cacggtatgg atgctgatgc tgaactgtct ggtattctgg ctaccgaaat catgctggaa 105660
ataaaccgtg aagttgttga ttggattaac tactcagctc aggttggtaa atctggtatg 105720
accctgactc caggttctaa agctggtgta tttgacttcc aggatccgat tgatattcgt 105780
ggtgctcgct gggcgggtga atcctttaaa gctctgttgt tccagattga caaagaagca 105840
gttgaaattg ctcgtcagac cggtcgtggt gaaggtaact tcattatcgc ttcccgtaac 105900
gtagttaacg ttctggcttc agttgatact ggcatttctt atgctgcaca gggtctggct 105960
accggcttta acactgatac taccaagtca gtatttgctg gtgttctggg tggtaaatac 106020
cgtgtatata tcgaccagta tgctaaacag gattatttca ctgtaggtta taaaggtccg 106080
aacgaaatgg atgctggtat ttactatgct ccatatgtag ctctgactcc gctgcgtggt 106140
tccgatccga agaacttcca accagtaatg ggattcaaaa ctcgttacgg tatcggtatc 106200
aacccatttg cagaatccgc tgctcaggct ccggcttctc gcattcaaag cggtatgcct 106260
tctattctga atagccttgg taaaaacgct tacttccgcc gtgtatatgt taaaggtatc 106320
taatctttga cgatttaagg gaccttcggg tccctttagt tgtttttatg gtataaataa 106380
atcatataaa ccaaaaggaa agcgcaatgg ctaaaatcaa cgaacttctg cgcgaatcaa 106440
ccacaacgaa tagcaactca atcggtcgcc caaatctcgt tgctttgact cgcgctacca 106500
ctaaattaat atattctgac attgtagcaa cgcaaagaac taatcaacct gttgctgctt 106560
tttacggtat caaatacctt aacccagata acgaatttac gtttaaaact ggtgctactt 106620
acgctggcga agctgggtat gtagaccgag aacaaatcac agaattaaca gaagagtcta 106680
aattaactct caacaaaggc gatttattca aatataataa tatcgtttat aaagtattag 106740
aagatacacc atttgctgat attgaagaaa gcgatttaga attagctctt cagattgcaa 106800
ttgttctttt aaaggttcgt ctattttctg atgcagcatc aacaagcaaa tttgaaagct 106860
ctgatagcga aattgcggat gctagattcc agattaataa atggcaaacc gcagttaaat 106920
ctcgtaaact taaaactggc attacagttg aattagcaca agatttagaa gcaaatggat 106980
tcgatgctcc taatttcttg gaagatttgc ttgcaactga aatggcggat gaaatcaata 107040
aagatattct gcaatctttg attacagtat caaaacgcta taaagttaca ggaattactg 107100
atactggatt cattgatttg agttatgcat ctgcacctga agctggtcgt tcattatacc 107160
gaatggtgtg tgaaatggtt tcgcatatcc aaaaagaatc aacttataca gcaacgttct 107220
gtgttgcttc agctcgtgcc gctgcgattc ttgctgcatc aggttggtta aaacataaac 107280
cagaagatga taaatatctt tcacaaaatg cctatgggtt cttagctaat ggtttaccgc 107340
tttattgcga tactaacagc ccattagatt atgtaatcgt tggtgtagta gaaaatattg 107400
gcgaaaaaga aattgttgga tcaattttct atgctccgta tacagaaggt cttgacttag 107460
atgaccctga acatgtaggt gcatttaaag ttgtagttga tccagaaagc ttacaaccat 107520
ctatcggttt attggttaga tatgctttat ctgcaaatcc ttacactgta gcaaaagatg 107580
aaaaagaagc aagaataatt gatggtggag acatggataa aatggcgggt cgttcagatt 107640
tgtctgtttt attgggtgtt aaattaccaa aaattatcgt tgatgaataa aacaaaggga 107700
ccgaaaggtc cctttttatt taacttacca attcaatcca agccggacga agtacatctt 107760
gtaccatttt aactaattcc tttttaatca aagaaggatt atccgcttga gttaaagtaa 107820
taccttcacg agaagtttct tccaaaatat cttgaacagt tagtcccatc acctttccaa 107880
aatcctttgg accaatttcg ccaattttag aaataacgtt atttactcgg ttcagtgtaa 107940
cgtagcaagc taaaattccc agcaatttat tatcagcttc tgacagctca actttagctt 108000
taataggctt atcagacttt ttcttttcac taaatttaga gttcttgcat ttgatagcta 108060
cgcgattgcc attaggcatc caagaaggat aacaaggttt caatacatat ccttcagcgg 108120
taaatacttc gccttttgct tcggcattcc aaacgcattt atttgcatca actaatccag 108180
cgtggtctac cgtaaaatta taatcctgaa cgacagaatc taaatcattt ggcaatttaa 108240
taagttcttc aaatttacca cgacccaaaa gtggagccat tttaaatttg aatgtattac 108300
agaatgattc catcatataa tcatcgacat aagtcacatc accactttct gtagtaacaa 108360
taatgtcaaa tacataaaaa tctttatcac cataatcgac attcttctga atgccaggtc 108420
cagctaattc gccgaagact tgataagata caactgccga agtttccata atatcttgta 108480
ctgctttaat ggaatcagcg taattcttta gaataatttc atacccaaag aaatcttcag 108540
caggaagaat cggtccagta cgtttagcac aagttgcttt atcgcgttca ataatcagtg 108600
agaaatttgt gccatgaatc ttttcacgag ctacccattc gccgccagtc aatcctaaac 108660
tgtaaagttt ttcaatgaat ttagaattgt aatgattttc aagactgcta tactttttaa 108720
acataattaa tcctcaaaat gtaatttcta accaatcacc atcacgctga tcactattga 108780
ctttaaagct aaatccttct tttctcagcc aatcaccaat ttcttcagta atcaatttat 108840
cgcgagcagt acaataataa ctaaaatatg ttttaccttg ttcagctgct ttattagcaa 108900
gttccgaaaa atctttaata aaacactcta gtttaaactg tttactttta agtgcttttt 108960
cgcgtaattg attagcgaaa gattcatttt cataaagatc atactgttcc atttttcacc 109020
tttttattaa tatgtctttt tctatagaca actttttctc gagtctcaaa tttattttta 109080
gcagtcatag ctcgagccca taatacagcc acttctttcg cctgtaagtt taattcacgt 109140
gcaatttcaa tgaatgactt tccagactca tgaagagtaa acaccacaac ctcagttctc 109200
ataatcaatc tcatgttatc gagttgatgc cattatatac aacgttttct gattgtgttt 109260
tgcgtgcttt caaaatgaag aaaggggccg aagcccctga gattatggat aggtatagat 109320
gataccagtt tctaaagcag ttttatgaat gatgtatcca ttgcgcgatt cttgaacatc 109380
aacttctgga tagtctttca tcatcttctg aagagtgtaa cggtgcaagt agtacttact 109440
atctgggtcg tcagttttcc aatctttacc ttcttcagtc attttttgga tttcatccat 109500
aacccaccaa ccgcaccaga tgtaagctga agtgcgatgt ggaagaggat gaacataagg 109560
taattcacct tctggttccg gagcaacttt atcagtcact tgaacttgac cttctgctgt 109620
gatagttttg ctatcatagt cagtagcggt aacagttgca gtaacttcaa tggtttgact 109680
tccaatagat gatgtatcaa cagtgtatac attagttgac ccttctacag gagaagaatc 109740
tttcttccat gaatattcga tttgcgcttc ttcaggagca tccgtaacat tagccgtaaa 109800
tgtagccgaa gcatcttgct gaacattaat agaaggagga gtcaatgtaa cctgcggatt 109860
cattgtcttc ttattaactg tcaatgatac ttcattagaa gtaacttcct ttgcgtcata 109920
atctgtcgcg gttacttggg ctacgcattt aattcttttt actccacttg tagttggagt 109980
atagctaaat gtagcggaag ttgcttcact aacaggagaa tcatctacat gccactgata 110040
cgtagcagat gcgcctgatg gttgagaagc taaagcagca gtaaattcaa caggagttcc 110100
aatcactcca gcagcaggac tatcaggagt tacagctaag gtagttgtct gtgtcttatt 110160
ttgaactgtg atagttgtag tagcttctgc tgtttcagca tcagtatctg gaactgtgtt 110220
tgttgcaact actttaatag tcttttgacc ggcaggtcct tttagtacat aactaaaagt 110280
tgcttcagct ccatcctgtg gaacatcgtc tacagtccaa gcataggtaa tagttccacc 110340
tccagtttca ccactgggtg tagcagtaaa ctgctgagtc tgatctataa ctccagtagg 110400
tgttttagga gttatatcaa ctgtaaaagc cataagttat ccttatttta atgttacgaa 110460
agaagagttg cgtgtttcac gaattagaac tgatccgtca cggttaatgt agtaaattaa 110520
gctaaataaa gtttgatgtg ccgacgcgtg ttcaaaacta gttgggtgag atttccaatc 110580
cggagtttca gcaatccact ggtaaatcca ccaaggaaca gtacagaatc ctggattttt 110640
tccaatcagc tgaagattcg gactaaagtt ttccggaaga gtaaatacag acggcttttc 110700
agattcaata atctcagcta cagcctgttc gaatttttct tcaacaaaag gagtatcttc 110760
aatcaaaaca tcggtatttt caggaatttt atccatttct actacttcaa ttttaatgtc 110820
agatttaacc ggagaatcaa tcagaagtgc tgcctctgga ttgacttctt catcgtcata 110880
ttttaatccg tctgcggcat cagcagcatc aattaagtct ttaatagata acccatcagt 110940
ctctggcata ggttcactag cgagcttctg gagggcttct tcaatatcat taacgatatt 111000
atcaaaagat ttattctttt tgacctttat accaaactgt tcagcatatt cagctaattt 111060
agctttagct tctttattat catcaagagc cttcagctct gcaatataat ctttatctat 111120
cataatattt cctcagtata aatatagata tatttattac atggtattta gacatgactg 111180
acattaaagt acatttttat gattttagtc acgtgagaat tgattgtgaa gaaagtacat 111240
ttcatgaact ccgtgatttc tttagctttg aagctgatgg gtatcgtttt aatccgaagt 111300
acaaatatgg ccactgggat ggacgaatcc gtcttttaga ttataatcgc cttcttccat 111360
ttggcttagt cgggcaaatt aaaaagttct gtgataactt tggctataaa gcctggattg 111420
acccacagat taacgaaaaa gaagaattat caagaaaaga ttttgatgaa tggctttcta 111480
aattagaaat ctattcagga aataaaagaa ttgaaccaca ctggtatcaa aaagatgcag 111540
tgttcgaagg attagttaat cgtcgtagaa ttcttaatct tccaacatcc gcaggtaaat 111600
ctttaattca agctttgctt gcacgttatt atttggaaaa ttatgaaggt aaaattctta 111660
tcattgttcc aacaactgct ttaacaactc agatggctga tgactttgtt gactaccgtt 111720
tattcagtca cgcaatgata aagaaaattg gcggtggagc atcaaaagat gataaatata 111780
aaaatgatgc accagtcgtt gttggtacat ggcaaactgt agtaaaacaa ccgaaagaat 111840
ggttctcaca gtttggaatg atgatgaatg atgaatgtca tcttgctaca ggaaaaagta 111900
tttcatctat catatcaggt ttaaataact gcatgttcaa attcggtttg tctggttcat 111960
tacgtgatgg caaagccaat atcatgcagt atgttggaat gtttggtgaa atatttaagc 112020
cagtaacgac ttctaaattg atggaagatg gacaagtaac tgagttaaaa attaatagta 112080
tttttcttcg ctatcctgat gagttcacta ctaaattaaa gggaaaaact taccaagaag 112140
aaataaaaat tattactggg ctcagtaaaa gaaataaatg gatcgctaaa ttagctatta 112200
aacttgcaca aaaagatgaa aacgcttttg tcatgtttaa acacgtatcg cacggtaaag 112260
ctattttcga tttaattaaa aatgaatacg ataaagttta ttacgtatca ggggaagttg 112320
ataccgaaac acgcaacgta atgaaaaccc tagctgaaaa cggtaaagga ataattatag 112380
tagctagtta tggtgtattt tctactggta tttcagttaa aaatctgcat cacgttattt 112440
tagcacacgg tgttaaatct aaaattattg tattgcaaac aataggtcgc gtattacgta 112500
agcatggttc taaaacaatc gcaacggtct gggacctcat tgatgattgc ggtgttaagc 112560
caaaatctgc taatacgaaa aagaaatatg ttcatttgaa ttatctttta aaacacggca 112620
ttgatcgtat tcagcgatac gcagatgaaa aatttaatta cgtaatgaaa acagttaatt 112680
tataagggct tcggcccttt ggagaaaaag atgttactag aatttaaaca atttctttat 112740
gaagcttcta ttgatgaatt tatgggtaaa attgcctctt gtcaaacatt agaaggtcta 112800
gaagaacttg aagcttatta caagaaaaga gttaaagaaa ctgaattaaa agatactgat 112860
gacatctctg tgagagatgc tttggcagga aaaagagctg aattagaaga ttcagacgat 112920
gaagtagaag aaagctttta aattaaaaaa ggcccaacca aaaaggaagg gccaaaacta 112980
tagactaaag gtcacactat agcaaaagtt gtgtttcatt taattgttct tccgaacttt 113040
ctgaaactgg tagttcttta atgtaattat agcaaggccc aggatgtaca ggacctttgt 113100
ctgtttcaac aaccaatgca gaatcgattg gagttttaca gacaacacaa atcttatctg 113160
acatgattgt ctcctctaaa ttatatatct atttatataa ctctcatatg catatcaatg 113220
cccatatctt tagaataaaa atattcatca agatatccgg caaattttcc tttaacataa 113280
agtacatctt caccgcatgg gtggtcggcc aggatacgaa tatcctgacg cttgagatta 113340
tactttttca ttaagaattg aatttccgtt tcaaattctt cttcataatt aaaagcatca 113400
tcaatgctat atctcattat tttccagcct caaatgctcg catgtcttga atatgcttaa 113460
tagcaaatcc acgtgattta atagcatcaa gagctccgct acagaaatcc aataaaattc 113520
cccaatattg taatgaagta tcaactttta aaacatcctt atcagctgat agaactgtct 113580
tcatttctga tttctcataa cggtccatac taaattcatc accatctcct cgtcccgagt 113640
agtagtctaa tttagcttta agagcaactt ttttctgcgc gtcaattcta agcatttcct 113700
ttttaatact tgaatgctta ttgagccatt tactatataa catcacatta ttagctgctt 113760
catactgtaa tttagtcgaa tctataaaca catctttctt caattcttct tgaagatctt 113820
ctaatctcat attgttctct attcaattgt tattggatgg acttagattc attataccac 113880
gtttatacgt gaagcattat actctgttac tggaagctag ttgtagtttt atctgctcaa 113940
tatcatcagg gttatcgatg actgaaaagc gtatttctac tatcagagta taatcatcat 114000
aaactggtat tacattaact gctaatttat caatacgtgg ctcgtagttt cttactgcgc 114060
tttcaatgtt acgctcaaca gtatcagcag taagaggagt catattctca aaaagctggt 114120
cagataaatc acatccaaat tccgggtcaa atggccttga ccctttcctg gttgtaataa 114180
ttcctaaaag actattttta attgacctta atccaagaga tctggaaacg tctttgtccc 114240
aatccatttt catttctggg tcaatgtcag aataaagctt attaatattt gccattacaa 114300
tagctcaaag aattctttga gtcctcttat tacatgagcg tgagattttc cacactctgg 114360
acatttaatt ggaacagcca aataaacagt aggctttaaa agcatatctt ttatagctac 114420
aatatctgac tctgtgatga tagaatataa atcttccaac tctttttcat tcaagtcttc 114480
aattggaatg ctttcgccgt tagcatgaat tgtttctata catgatacta tcatgtgggc 114540
tatgttttta tcatcaaaaa ttttagggta atggaactta attttaatgt cacccagtgt 114600
ataccagagg tcttctggtg catctatttg tgtatgtaat agatttatat gggttggtat 114660
ttcagttcca caggtgcact tccaggagtt ttcgtgatta acttctccaa gagaatgcgc 114720
ccataaatga atcaacaata gttctgattc ttggcggttt aaatcttttg catttgtgca 114780
gtctttgatt agctttttaa cgatctcttc tactgaaccg ttctttttag cagtaataag 114840
ttctagatat tctttaagag taaatgcgcg acagttgatt attttagaac caactctcac 114900
gtcaaatttg tattcataca tatttagctc ctttatttat catatttata aatagaataa 114960
aaggagcatc tatggcaaac attattcgtt gtaaattacc agatggtgtt catcgtttta 115020
aaccatttac ggtagaagat tatcgagatt ttttgttagt tcgaaacgat atagaacatc 115080
ggtcaccaca agaacaaaaa gaaataattg ctgatttaat tgctgattat tttggagact 115140
atccgaagac ttggcaacca tttatatttt tgcaggtatt tgtagggtca ataggtaaaa 115200
ctaaagtacc ggtcacattt gtatgtccaa aatgtaaaaa agaaaagaca gttccatttg 115260
aaatatatca aaaagaatta aaggaacctg tttttgatgt agctaatgtt aaaattaaat 115320
taaagtttcc ttctgagttt tatgaaaata aagcaaagat gattactgaa aatattcatt 115380
ctgttcaagt agatgaaaca tggtatgatt ggaatgaaat tagcgaatca agtcaaatag 115440
aacttgttga tgcaatcgag atagaaacat tagaaaaaat tctcgatgca atgaatccta 115500
ttaatttaac attgcatatg tcatgctgta ataagtatgt aaaaaaatac actgatatag 115560
tagatgtgtt taagctatta gttaacccag atgaaatatt tactttttat caaatcaatc 115620
acacgctcgt aaaaagtaat tatagcttaa attcaataat gaaaatgatt cctgctgagc 115680
gcggattcgt attaaaactg attgagaagg ataaacaata atgagtatgt tgcaacgccc 115740
aggatatcca aatctcagcg ttaaattatt tgatagctac gacgcttgga gtaataatag 115800
atttgttgaa ttagctgcta ctattaccac attaactatg cgggattctc tttatggccg 115860
aaatgaagga atgctgcagt tttatgattc taaaaatatc catacaaaaa tggatggaaa 115920
tgaaataatt cagatttctg tagctaacgc aaacgatatt aataatgtta aaacacgaat 115980
ttatggatgt aagcattttt ccgtgtcagt agattcaaag ggtgataaca tcattgctat 116040
tgaattggga actattcatt ctatagaaaa tcttaaattt ggcagaccgt ttttccctga 116100
tgcaggtgaa tctataaagg aaatgcttgg cgtcatttat caagatcgca cattattaac 116160
tccagcgata aatgctataa atgcttatgt tcctgatatt ccgtggacta gtacatttga 116220
aaactatttg tcgtatgtca gagaagttgc tctagctgta ggaagtgaca aatttgtatt 116280
tgtgtggcaa gacatcatgg gagttaacat gatggactat gatatgatga taaatcaaga 116340
accatatcca atgattgtcg gtgagccatc tttaataggt caattcatcc aagaattaaa 116400
atatccatta gcatatgatt tcgtttggtt gactaaatcg aatcctcaca aacgtgaccc 116460
aatgaaaaac gctactatct atgcgcattc atttttagat tcttcattgc caatgattac 116520
tacaggaaag ggcgaaaact ctattgtagt gtcaaggtca ggtgcttatt ctgaaatgac 116580
ttataggaat ggatatgaag aagctattcg tcttcagact atggcgcaat atgatggcta 116640
tgctaaatgt tctactgtcg gtaattttaa cttgactcct ggtgttaaaa ttatttttaa 116700
tgatagtaaa aaccaattta aaacagaatt ttacgttgat gaagttatcc atgaattatc 116760
caataataat tcagtaactc atctatatat gttcactaat gcaacgaaac tggaaacaat 116820
agacccagtt aaggttaaaa atgaatttaa atctgatact accactgaag aaagtagttc 116880
ttccaataag caataaagaa gtttctattc ctaaaatggg tcttaagcat tataacattt 116940
taaaagatgt taaaggccct gatgaaaatt taaaacttct tattgattct atttgtccga 117000
atttatcacc ggcagaagtt gatttcgttt ctattcatct attggaattt aatggaaaga 117060
ttaaatctcg taaagaaata gatggttata cttatgacat taatgatgtt tatgtatgtc 117120
aaagattaga atttcaatac caaggaaata cattttattt tagaccgcct ggaaaatttg 117180
aacaattttt aacggtgagc gatatgttat ccaaatgctt gcttaaggtc aatgatgaag 117240
ttaaagaaat taattttctt gagatgccag cattcgtttt aaaatgggca aatgatattt 117300
ttacaacttt agcaattcct ggccctaatg gtccaataac cggaattggc aatattattg 117360
gattatttga atgaaaaagc cacaagaaat gcaaacgatg cgtagaaaag ttatttcaga 117420
taataaacca acacaggaag cggctaaatc cgcttctaac actttatctg gacttaacga 117480
tatatctacg aaattggatg atgctcaagc tgcttctgaa ttaattgctc aaactgtcga 117540
agaaaaatcg aatgaaataa ttggagcaat tgacaatgta gaaagtgcag tgagtgatac 117600
tactgctggt tctgagttaa ttgctgaaac tgttgaaatt ggcaataata ttaataaaga 117660
aatcggtgaa tcactcggga gcaaattaga taaattaaca agtttactag agcaaaaaat 117720
tcagacagcc ggaattcaac aaacaggaac tagtttagcc acggttgaaa gcgctattcc 117780
tgttaaagtt gttgaggacg atacagctga atctgtgggt cctttattac cggctcctga 117840
agcagttaat aatgatcctg atgctgattt tttccctacc cctcagccag ttgaacccaa 117900
acaagaatcg ccagaagaaa aacagaaaaa agacgcattt aacttaaaat tatctcaagc 117960
tttagataaa ttaacaaaga ctgttgattt tggatttaag aaatccattt caattactga 118020
taaaatatca agcatgctat ttaagtatac cgtcagtgct gctattgaag ctgctaaaat 118080
gactgcaatg atattggctg ttgttgttgg aatagatctg ctgatggttc actttaaata 118140
ttggtcagat aaattttcgc aggcttggga tttgtttagt tcaaacttta ctaaattctc 118200
tagcgaaacc ggaacatggg gtcctttatt acagagcatc tttagttcta ttgatgaaat 118260
taaaaaattc tgggaagagg gagattgggg cggtttgacg gtagctattg tagaagggct 118320
tggaaaggtt ctttataatt taggagaact tattcagctt ggaatggcta aattatctgc 118380
tgcaattctt cgagtcattc ctggcatgaa ggataccgct gatgaagtag aaggaagagc 118440
actagaaaat ttccaaaatt ctactggagc atctctcaat aaagaagacc aggaaaaagt 118500
tgcaaattat caagataaac gaatgaacgg agaccttggt ccgatagcaa aaggattaga 118560
taaaattgct aattggaaaa ctcgtgcatc taactggatt cgtggcgttg ataataaaga 118620
agcactaact accgatgaag agcgtgcagc agaagaagaa aaattaaagc aactttcacc 118680
agaagaaaga aaaaatgctt taatgaaggc taatgaagca cgtgccgcaa tgattcgctt 118740
tgaaaaatac gctgattcgg ctgatatgag taaagactca acggttaaat cagttgaagc 118800
tgcctatgaa gaccttaaaa aacggatgga tgacccggat ttaaataatt caccggcagt 118860
taaaaaagaa cttgctgcta gattttctaa aattgatgct acttatcaag agctcaagaa 118920
aaatcagcct aatgccaaac ctgaaacttc tgctaaatcg ccagaagcaa aacaagtcca 118980
ggtaatagaa aagaacaaag cacagcaagc tcctgttcaa caagcatctc cttcgatcaa 119040
taatactaat aatgttgtta agaaaaatac tgtcgttcat aatatgacac ccgtaacgag 119100
cacgactgct cctggtgtat ttgatgcgac tggagttaat taaggaataa tatggcaatt 119160
gttaaagaaa taactgctga tttaattaaa aagtccggtg agaaaatttc agccggacag 119220
agtactaaat cagaagtagc aactaaaaca tacactgccc agtttccaac tgggcgtgct 119280
agtggtaatg acactacagg ggacttccag gtaacagatc tatataagaa tggattatta 119340
tttactgcat acaatatgtc atctagggat tctggaagtc ttagatcgat gagatctaac 119400
tactcttctt catcttcgag tattttaagt acagctagaa acactattag tagtacagta 119460
tcaaaactat caaatggatt aatatcaaac aataattcag gaacaataag taaagctcct 119520
gtggcaaata ttcttttacc gagatctaaa tctgatgttg atacatcatc acatagattt 119580
aatgatgttc aagaaagtct tatcagccga ggcggaggta ctgctactgg cgtgttaagt 119640
aatattgctt caactgcagt atttggggca ctggaaagta taacgcaagg tataatggct 119700
gataataatg aacagattta tacgacagcc agaagtatgt atggcggtgc tgagaataga 119760
actaaagtgt ttacatggga tttgacgcca cgttcaacag aagatttaat ggctattatt 119820
aatatctatc aatattttaa ctatttttct tatggtgaaa cgggcaaatc tcaatatgct 119880
gctgaaataa aggggtattt agatgattgg tatcgttcta cattaattga acctttatct 119940
ccggaagacg cagctaaaaa taaaacacta tttgagaaaa tgacatcgag tttaactaac 120000
gttctagtag tttcaaaccc aacaatttgg atggtgaaaa actttggtgc aacatctaag 120060
tttgatggaa aaacggaaat atttggccca tgtcaaatac agagcatcag atttgataaa 120120
acacctaatg gtaactttaa tggattagct attgctccaa acctccctag tacatttact 120180
cttgagatta ctatgagaga aattatcacg ttaaaccgtg cttctttata tgcggggact 120240
ttttaatgta ttctttagag gaatttaata atcaagcaat aaacgcagat tttcaacgca 120300
ataatatgtt tagctgcgtt tttgcgacaa ctccatcaac taaaagctct tcgttgataa 120360
gttcaattag caacttttct tataataact tgggtctaaa ttcagattgg ttaggattga 120420
ctcaaggcga tattaatcag ggaattacca cgctaattac cgctggcaca caaaaactga 120480
taagaaaatc aggggttagt aaatatctta ttggtgccat gagtcaacgt acagttcaaa 120540
gtttattggg ctcatttaca gttggtacat atttaattga cttctttaac atggcatata 120600
actcatctgg attgatgata tattctgtaa aaatgccaga gaatagatta tcctatgaaa 120660
ctgactggaa ctataattct cctaatattc gtataactgg gagagaatta gaccctttgg 120720
ttatttcatt taggatggat tcagaagctt gtaactatcg tgcaatgcaa gactgggtta 120780
acgctgttca agacccagta actggactgc gtgctttgcc acaagatgtc gaggcagata 120840
ttcaggttaa tcttcatgct cgtaatggat tacctcatac tgctgtgatg ttcaccggat 120900
gcattccagt gtcagtgagt gctcctgagt tatcatatga tggagataac caaataacta 120960
catttgatgt tacttttgcg tatagagtca tgcaggctgg gtcggttgat agacaagctg 121020
cgcttgagtg gcttgaatct gctgctataa atggcattca aagcgttctc ggaaatagtg 121080
gaggcgttac tggattatct aattcgcttt cacgacttag tagattaggg ggaactgcag 121140
gaagtatttc aaacattaat actatgacag gaattgtcaa ttcgcaaagt aaaatattag 121200
gagcaatata acaatgggga cctaaaggtc cccatatttt tatttacgga atgaaataaa 121260
agcagcaact gaagcaacta aactgtcttc aatataaact tcaattttta ccggagcttc 121320
tgactcaaat ttacctgtta ctacaccttg gaaaatgctt tcagtctgtt ctggctttga 121380
aaaattttca gaaggaaaaa ttccgaactt tttatctgtt ccaaaaattt tgataaattc 121440
atcataaact gcttcattaa aagcattatc agcaggaata acgccttcaa ctacaagttc 121500
ttgacctaaa aagcgcaaag aagatttcat tttgtgttcc tcatgttatg tcagtaaaat 121560
tattataaca caacacgagg gacttgtaaa ctacatcttg aactttttag acattccgtc 121620
gatgttaacc aaagaagcta agatttgaga aacttcgttt tcctcttctt ttgattcttc 121680
tacaaggaat tgattaaacc cagccattgg acgaacttca ccagtttcca ttagatgatc 121740
gccatcatat accgattctt ctaattgttc agaaggagga acgattgtgc cttcgattag 121800
atacttgtta taagcagttt ctttcatcat gtacgtactc actttattaa tcttcagcaa 121860
aattccacgc ggtagaataa cttcagcttc tgatggaaat cctgataaat gacctggaac 121920
gataactttg attcgctcag ctcctttaat taccataccc acgctagttt cagcatcttc 121980
attcgcataa gcagagtgac tgcccatatg catcaaatct tctgcgtcaa ctgaaccttc 122040
tccttcacca gaaaatactg cactggaatc atctagagcc atatagtttt taccatactc 122100
accgaagata tttggtttaa gcgatgtgga tacgaagttc ttgaaataga acattttatt 122160
ttcaatatta tgacgtaaag ttttaaaggt aacttcttgc ccacggtaaa gtgtagttcc 122220
tggaggaaga actgatcctt tggcaaaggc agaatccatt gtctcgatgt gtttaatagc 122280
tcgttccatg tattcttcac gagtagaatc tggtttacct aagaggaacg agttcatttc 122340
aacatatgaa tccgcgcaat aatcttcaat tacatcagac tcagcctgag ttaatccttt 122400
tggggttact tcagtacttg catattcata cgcttgagaa gcagattcat taatcaattt 122460
ataaatgcca ttcatgacaa attgaataat agctaccttt tcgtctggcg tggctttaga 122520
acctttaact aaatcattga taattttctt aataacatca aagctattag aaatattaat 122580
gtcagcaaga tcgcttaaaa ttttatcagt tttataatca aaaaattctt tattctttaa 122640
atattcttga gaaccttgat atgttatatc gctctgtaat ttaatagatg gatcacgtaa 122700
acgcgcatgg gccaatgcaa tatgatttct gaagctttct agttcataat cactagattt 122760
aaaacgagaa gcactcctca taccaccgat agctcctttg ctgaagtttg aaccaacctg 122820
aataacgccg gagttcattg gtccttctgc tttatatacc ggaactttag attcaaactc 122880
ttgatatttc ttagcagcga agctatcacc ctgaagtgaa gcatcgacag tagaatattg 122940
agcttgtgct gctaatcgac gactaatttt agttttctga ataacagctt gatccgtgcg 123000
cttatcattt tctaaagcaa tagaagcagc aacagcaaca gctttaggga cagcattacc 123060
tgttttaaca tctacataca catcaccaac ctttgattca acttttgtga ataactcagt 123120
tgaaatagga ggtacacctg gaatgtcttc taaattggca tttttacggt aaaccataat 123180
atatgcatac tttttatcat agtcccaaat ttcctttaaa agaacatatc gacctgctcc 123240
tttagtacgt actaaacggt cagcaataac ttgcatttga cgagcagcgc catttgtttt 123300
actctttagt acgcggaata ggcatgcgtc aattttgtac tgtttcattg tctgaagagc 123360
agtatcaaaa accgcattaa taacaccaat tggatttcca cccaagtttt taagtttaac 123420
taatgatagt ttctcattaa cacctatcat tacgatatgc atcattttat cgcctggctt 123480
aacgttttta tttgtatcac cgccagaggt gtatgtacaa aatctaaatc caggaagcac 123540
actttcttca ccagcttgaa tagcaaaaat ttgaggtatt ttatgcttag gatttaagtt 123600
aacaaccggc gccgaagcgc cgtcaaataa ttctgtaata agttccatga tttatccttg 123660
aacgaacttg taaggcatgt ttgtaatatc tatgcaagac gcaataaatc caagagatga 123720
ttctactttt tgtttaacat ttgatgaaac aaatgatgca aagtcaactc tgtcttctat 123780
ttcaatatca cctgtcattg caactacttc accagtttcc attagacggt caccgtcata 123840
aatgactgat tcggtgagtt cttccgtagt cataacttca gcttgaatga gttttgtatt 123900
attagatgtt gttccgtcat tattagaagc gtcagttatt ttattaactt tgaccatcaa 123960
tccgcgtggt agaataactt cagcttctgt tgctattccg agacttcctg gatatacaac 124020
attaacttta tgagctccat caatagccca tcctatttga actttaacgt attcaggatt 124080
ttctttatac gctcttattt cgtttggatt aatagttatt ccttcttcat ttttatcaac 124140
tgtcaattca ttgcgagctt ctggttctaa aagaccaata ccagcatgcg taattccaaa 124200
acgcccaaaa atgataggag ttaaagaagt agatacaaaa tttctgaaat agaacacttt 124260
atttttaact agtgcttcgt atataggagc agtcatactt tgagcacgat aaactgtaat 124320
gccttctggt atacggtcac cattttcaaa ggctgaatct aaattattta tcgcagattc 124380
aatttctttt tcactcatta catcatatcg ttctggattg tagcgtccta aaagaagatt 124440
attgatgtca gtatatcctg aaccacaata ctctctaatg ccgcgctttt gtgatggagt 124500
atatttagaa ccatcacggg caatagtaat atcaatcatt ggacctgcac caattccaga 124560
aaagctataa atcattcttt tgaggaattt agtttttgcc gcgttccagg aatttttagt 124620
catttcttcc cagacttcat ctggctgtcc tttacgggtt ttattatgtt tatcaagcca 124680
agtatcttta tattcttcaa agaatttatt aatagctgct gcatacttct ctaaacattt 124740
tattgaagta gttggttcat ttttgatcgc gttaaaaatt acgtctttaa ttttttcaga 124800
aacttcatta acctcacttt ttgaaaagaa tttataatca tagtgaagtt catctgcagt 124860
tccttcggca ataatttttg ctgctttagt tttagaagct aatgaattaa ttccaagctt 124920
catttcttct gcttcgggaa ttaaaggagc ggtagcaggt ttattgaaat tagctgcggt 124980
agattcatac ttctggaata attcgctttc aaatctagaa gattctaatg actgactttg 125040
tgcaattgct ctacgggaaa ttttaacttt aacgattaca gcttggtcag aacgtttatc 125100
attttcttgc gcaatagatg cagcaattgc ctcattttta gttacttgag ctccagtatc 125160
tttattgata taaacatcgc cgaccttcga ttcaacttta gtaaagagct cggtactaat 125220
ttccggaact cctggaatgt cttctagtga tacatttttg cgatgtataa gaatatatgc 125280
atacttttta tcgtaatccc agagttcctt aagaaggacg tatctgccac ctgaacgact 125340
acggataagt ctatcagcaa taacttgaat ttgtcgagct tgaccagcag ttttagactt 125400
aagaatacgg agcatgcagg catcaatttt atactgacgc atcgtttgca ttgcaacagt 125460
aaaaactgaa ttgatgtaat taattgggct tggaccgaga ccttttaatt tagcaattga 125520
acctttagca gttaatgtaa aaggaacaat atgcatcatt ttatcgccca tttttaaatc 125580
gcgattagta tcacctccag atgtataggt acataaacga aagcctggtt gttcaattgc 125640
gtcatcaaca tgaactgaaa aaatttgtgg tattttcttc tttggattta agtttgtaat 125700
cggaagagta gtatcttcgt caaataattc tgtaatgagt tccatcatat cctctctagt 125760
gtttattcta tttataaaat taaaggcccg aaggccttta ataatctagt ggtaagagag 125820
tacgatatat ttcaaacttt ggaccttttt cgtaggcatc aaatgtttct gtaaatttat 125880
tataagcata tgcatctaca aattcgagaa tgacttgtga tacagaagta gaaacatctc 125940
caccttcttt ttgagcaatg acaattgttt ctaagtaagc tttcatagac cagttacctc 126000
atgaaaatca ccaaatacat cctcgaatgt attagcttta gttttatctt cgcgtaaacg 126060
aatcgcaatc ggaagaaata atttaacgta atcagtgcgg ccatcagatt ttaaccaacc 126120
attgcattcg cactctagaa tttttccaat ataataattt tggttttcca taatgcgagt 126180
acggtcaagt tcatgtgatt ttacaccggc tttatctttt aagcctgaac cagcatttac 126240
tttaattttt ccacattctg attcaagaat aaatccaccg gctttagtag ggtctttacg 126300
gtgaggataa attcctacaa tttttaaatc aacatcaatt acttctttaa atttatagag 126360
attttttgaa cgagcatttt cccacaatcc atcggtattt ttgagaataa taccttcaag 126420
accttggtca atatattttt tataaattac cttagcttca tctaggttat ttactacctg 126480
gttttcaatt aaaattactt tatcatatcc tgatgtcatt tgttctagtt tagaaaaacg 126540
tacatcatat tttaaacgaa acgccggaag accgtatatt tctaccaacg ggacataatc 126600
ccagacctga aacttcatac attgagcttc tttttcagaa atggttcctt ttaaggattt 126660
attggcgatt ccattagaag tagtacgaga ttccgctact tcggcgaatt ctttagcttt 126720
actaatttca ggataagcat caaaaagaaa atctaggcct tctggttcct ttttaacttg 126780
ctcatggtat accaattcgc catcaattaa cacaccttct ggatgaattt ggcgggcttc 126840
agcagtcatt ttgattaatt cttccttaag aagatctaat cctagatatt cattaccagc 126900
tcgtgataaa agacgaacat catctaattc atcgcctcga acttcagcaa aacaccgagc 126960
tccatctgct tttaactgtg caaaagctgg aaacttgata ttcttactaa tgcctttttc 127020
atcataagaa cttgccagca tttgaggttg ttcaggaatt aaacctggcc aaactttgtt 127080
tgcaatagat actgaagcac cgcattcaag gtctcgcatc atcactcgac gcaaaacttc 127140
aacatcatcc tttttaccat cggtgatata tccagtcaat tcctcaattg cggcatttcc 127200
ggtcaatttc cgagtagcta acgtgaattc aatgaagtca agcatatcgg taatagtcag 127260
cattccaaaa ctctgggtag caataccagg tttaggccat ttcttgatat aatactgtaa 127320
cccacgagaa taagtcagac gatatactcg tttaagcaat tcattatctt tattcttttc 127380
aagaattgct tgcttctgct tagttgatcc aatagatgct atttcattca gaattttaag 127440
aatcattgct catccttcaa ggtttggttt acagctctat tataaatcaa ttcatcatta 127500
agctcaggca aagacttatg atatgtagtt ctaactttat ttccttgcat ccaatgcttg 127560
acgtaaatga aaccttgctc tacacatttt ttaaaaattc gttcgtcttt ttgagctcgg 127620
aattctggat tgcatctaaa aaattgattt acgtgaccgt aatcacgtgt agtattacct 127680
tcattttcat aaatagtgtg aacaacaaac attagaatgc tccttggaaa atattatcac 127740
cactagtaaa tctattaaaa taccctgcat caccaggctt agtataactc cacgtatgga 127800
atggattcat atgatacggg tgtgtataat atggattata tggatgtgta taatatggat 127860
tatacggatt aaatccagga gttctccagg tagtgttcca acgaaaagaa tcgtttttaa 127920
ccatcttctc aattacatct tttatagctt tttcactatc aaaactttct ttattttcct 127980
tcggtgaaaa aagcttattt tctacatcat tccatgtata aactcgctgc gcagtttttg 128040
gaatattgtc acgttctcct cgagccatcc aataaaccgg aacatttaat atttcactcg 128100
cgtggtcgca gtggtgagca agatcgtcaa tataacaaat tacgttatat ttctcttttg 128160
cctttttgaa caactcttct tttgaagaat catgaccaca catcattact tctgagaagg 128220
caccaggaaa aagagcattc aaattaaatt gacgatttaa cagagcgtca atagaatcac 128280
ccaatgctgt aacagctaca aaattataat cttcttttaa tttgttaatt acacacagtg 128340
catctttata tggagacaaa taacgaataa aatctgatcg attatatttt tcaattaact 128400
tgacaccaag ttcttcatca caattaaaga gtttacctgg agaaataaat ttctcatctt 128460
ggatcatttt taaaatatgt tctaacggaa gattatattt ctgggcaaaa taaggaaggc 128520
ctgattgcca gcttaaacat actccatcaa tatcagtcaa aatagtaggc ttcatagaga 128580
gtctcttaat aggtttaaca catcaataaa ttcagcttcg gttagtattg tatcatcttt 128640
tgttagacca ctagccatgc tgtgcttcaa aacttttcct ttcgaggctt gtaatgcatc 128700
gcgaaagccc ttgttttgga tcgctgcttc aaaatatgca tttgtgtata attctttcca 128760
cgctggagag tatcttgaaa atggaactcc aagccaaaag agggtcccac ggtcctgagc 128820
tctagcataa gaccttccag cttgttgggc ggcaagcccg gataacccaa atatacgtct 128880
ttgctgttca acatttttca ccttacatcc ttggaggaat ccttcgagac ctccaaattg 128940
gataccgtcc ataacaaaag gccattgggc gaaattactt aatgcacatg atggccatct 129000
aaaattgctt ctaatctcta actcagacat ctttaatact tataatttca atatcagccc 129060
aatgaccata acttggtaaa cggtcttcaa tagataatcc gccatcatat ttaagcattt 129120
taattgtcat aatatatggc tctaaatggt cttcagtgag cggagagaca tcagtcacac 129180
gataagtaac ttcgaccatt tccgtgccca gtaatttctg gattaatttc ttaaacattt 129240
tattaaaatc tcatctgaaa accgtgtgat ttaacattac cgccgctgat atcagaaatg 129300
ttaatttcgc gcgcgattga agggtcaatg tcaatttcac gattgagttt agtgatagct 129360
aaagtatcgc gtccatttac agtacggaac tctaaagggc agactacatt aacatagttt 129420
ttaatcgatt cactagtagg ctgcaaatga gcaggaaggt ctttaggtgc cttagagaaa 129480
accacttcac agaaattttt gcgggtatca aaataagtag tcataaacat agtattttcc 129540
tcagtaaggg gccgaagccc ctcattttat tttaaatatc aaattcgtta agaactacat 129600
caaagatcgc ttcaagatgc tcaggtttag ctctgttact cagaatatga cgaatccaag 129660
ttttaaccag aagcttacga ttgacgccat tccagcaagg atgagtacct aaatcgcgtt 129720
gacggaaatc atcatctaat gcgattttaa aagaagaacc ttctttcgtg attgaaaccg 129780
tgatgccatt ttcaaatcgc atataaacgt agttaggagt catatactgt tcaatttcgc 129840
atactgatcc attttgatgt ttccaaaggc agatagtatc aatagaacct gcaataccgt 129900
tagaaacata tttacgttca aagttgatgt agttcatttt attctccgag atgtttaatt 129960
gcggtacagg tatataatat catatcctgt accaaagtaa acaattattt tactactttc 130020
cagtgctgca tgtcaagttt accaactttt ttcatcttct caattaagcg ttcggcacgt 130080
tggcgagctg taacataata ccattcaccc aattcatttt gttcaatttt tccaacgatt 130140
actgtattca attcataaat ccaaccagta aagaaattat gaacttggat tgtaaaggtg 130200
aaatctgttc ccataccttc tgctgtttct acttcaataa tatcaccttc aactgccatt 130260
aagaaccaca tagtttcatc atatttacca ttgaagcatt tagttttaac tgtagcgttc 130320
agattaatcg ttttcatttt attctccttt gtttgtgtaa gataatacta tcacaaaaga 130380
actatactgt aaacaacttt atgcaatctt tggaaaataa aaaaggactc ccgaaggagt 130440
cctcaactta tgctttctgc ttaccaaaac gagaagcatc atctcgaaga accgcacgtg 130500
ctcggcgcat gatcttctca acagtttgat tgatacgaga gttcgaccca cgcttgtaac 130560
cagcgcgttt agaatcacca actttctttt caactgcttt ctttgcttta gcttgttttg 130620
ccattataaa ttctctttta aatgaaaatg caggacttat tggcattgcc tgcgaaagcc 130680
ctcaaggggt acttaggttt tgagtattta ccgacaggat aaccataaac ctcgtcaaca 130740
ttcaagaggt acaccgtaaa acaaagttcg acggctcctc gttttaactt cacactaagg 130800
cagtgactct ccaataaatt acttcagtgt taccacaaag tgacgaactg cttttcgtgc 130860
agcagaagcc agaggcttag catatttaag ttcatctttt tcctgaagct cagcagctaa 130920
tgcagtttga gcaggattca gatgtttgaa ataacgcagg atttcaagag cttcggcttc 130980
aacatcaata gatgcgccat agttttcgtg accattattc catgcgtttc gttgcagttc 131040
aagagcgtgt tgtaattgtt taatcattta aaaattctcg ttagagatta aaactcggta 131100
gtcacgttct tctgaatttc atcttctttc gacagatctc tcagttgtag actaccacat 131160
agaattgttc ggttaactta ttattccgac acccaattca tattattatt tatatcactt 131220
ataaagacac ggaatagctt tatagtgaca agtaacgaat ttttgtttaa tttcttttgg 131280
ctgcttaaga cccagagcta caaaaggatg cggaacgttt cgaatttgac caactggaag 131340
agaagtcaaa tcaccaactt cgcagaaacc ttcaggaaca tcaggaccaa cagagtgaac 131400
tacacacagt tcaggaactt caccttggac acgtttaccg ataataagtc ctgattctgt 131460
aacttcttca tcaccggctt gtgcaggttc agaaactaaa ataacatatt caccgacagc 131520
acgaattggt agctgttgta cttcagacat cgtttttcct ttttgttaac agatgagtta 131580
ataataacaa ataattctta aagcatttat ttaccaataa attgaagcaa atgctcaact 131640
ttcataccat taacggaaat caatttgtca atagaaaagc ctcgccatgc accaagctca 131700
acatcaaata ctggaatcat atcaatagat tctttccgag tagattcagt caatttacca 131760
gtttgcatgg ttggcataaa gtctgcatca cgagtacctt tcatagtacg aatagtacca 131820
tcagactttt caaaaaccac gtttgaaata cccatggaca atttagtttt caaaatttca 131880
cgaattgcta ctttctgttc agttgtcaat ttcatttatt tacctattac agttttaata 131940
tgggttgttc cacgttcttt aagagtggaa agcaactttt ggcatttttc taaatcagat 132000
ttccaactat acggtctatc aatacaaacc cattctgact tataatactg cttccattta 132060
gagaaaaaat atttcttata ctctacagca aatgaaatgt tctcgttaga ataagaacta 132120
attgctgtga gctgtaccaa acgaaatttc attattcacc acagaattcg ttgatatttt 132180
cccagtttaa cttattcaag tttttcttag gaacattaaa cacttcaata cccgcatttc 132240
gcagaatatc atcccagcca ggtttatttt tatcgtatgt ttcgcaataa accagctttt 132300
taataccaga ttgagctatc gcttttgcac aatctgggca aggagaaagt gttacataca 132360
tagtagcacc ttcaattgaa gaaccatttc gcgcagcaaa caaaattgca tttagttcag 132420
catgaatttc atttttagac gaccattcag agtgagcgct gcggtgttct ttcgccaaaa 132480
caaaacgatc agttgaacca aatgatacac attcaggctt atgaccttga atgatagtat 132540
gtttaggctt attcagcaac caaccttgct cggcagcata atcacagcaa ttcacacccc 132600
cggcaggtga accattatat ccggtagaaa taatacgtcc attcttttca attactgctc 132660
ctaccttcca ggagcaacat tttgattctt gtgatactaa atatgcaatt tgaagtactg 132720
tactcgcttt catttcataa tcaccagata agcagattta gcagtttcaa cacgataaat 132780
ttcgtgacga agtttagtta tacttttaat aacagaacta attatattct gcccatcttt 132840
aaagcggttt ttcttatcaa taaaaattgc accagtcatc tttttgtgaa gctcaactgg 132900
atacttcgtc acaataatag catcatacac agaaggatga atgctattca ctagagtatc 132960
attcattaaa gttattctaa tgaactgtgc tgtttcagaa tcaagcgctc tatgatcgcc 133020
agtatcattt tcaagacaat tatcaattat atcagttaaa ttcatcatag tacgccatac 133080
accctttgtg cttcaactaa tccatcaaaa tccaatttga gatgtgttat ttgatcacca 133140
tcgcctggat tcacaattac taatactgaa cgaggagttt cggtaataac acgaaccgat 133200
gtttcaggaa atcgttcaga aaccttattt accaattcct gagcaaatag tttaactttt 133260
tcttggaatt ctctagtagt aattggtttt tcacttagca tgttgatccc agctccttac 133320
tttcaacgtt tttaactaat ttgacagaaa ctaattcggc atcttgggta atcattaccg 133380
ggccttcttc atactcttca agatattcta gagctttctt tttagcttct tccttcgtat 133440
cagtttgagc atagatatag aacatacaac cagtaatacc tactactttc cacttaattt 133500
ctttatcagt tttaatttca aatttactga tagagtcatc tttttgaact tcttcgaaaa 133560
aataatattc tgacatataa gtaattgaaa ataacgggct atctttataa gattcgccca 133620
ttacatcaac agctttatac cagcagtcat caatttcacg tttaatgcta ataacatttt 133680
tagcagaatc tatttttact ttaaatgaat tttccccaat aaactgggca attcgtttat 133740
tagccccgca agtttcatta aaaatatctt tatatccagc tttaaagcga taaaccttat 133800
cttcttcaaa ccatttgctc atttcaattt cctcatttgt tttggtagag ctataatatc 133860
acaattctac cgtaaagtaa actattaaat tgctttgaat tctgatgtct gtgattcaaa 133920
gcgaatatcg cctttgatga ctagctcagc atcaagaccg aatacgacaa taatatgagc 133980
agaacctgga tacagtgtaa ttgcaataga atccacctgg tctggaagca aagtgttcaa 134040
tacatgagtc acttgagcat gaattcgaag ctcagctgca ttatcaaact tttcaaacat 134100
attattagcg ataatttggc taaacactac ttctacgatt ttagagtaag tcggaaacat 134160
atttacctca cataattttc ttcaagccaa ttaataacat ccaacgcatt atcaaaagtt 134220
gaaccatcta ctttgtcttc tgtttcataa tcaagaacat ctaagcctac tcttccatca 134280
acaataggcc ataaacaaaa tagatatttc ttttcttttt caattttatc acaaagtcga 134340
taaatctttt ctatgttatt cataagtttt ccatggtaaa ggcagtttag ttttctttac 134400
tgttagttca acatcaggat tcttttctct taatttaagg cattcctccc aagctctgat 134460
ttcactagtg aatacacaaa attgcccatt actagtacca actaaaccgc tatttacaat 134520
aacaatagac caagtttcat gatgccaagc cattaaaagt caccatggtt aacttgccag 134580
cattcaacac caatacgacg ccacatttca acgacttggt ttcggtcatc aactgcaagt 134640
ttaacatcgt aattaggcgc aatgtgtttc cagaaaattt cttctttaac tacatcatct 134700
ttacgagtat caccttgttt gcgttggata tgcaaattaa acggaatatc gttttgtaaa 134760
agccactcac gtgtcataac ataatatttt aacttagcat tttcggtgcc agattcacgt 134820
ccgcttaccg taataatctc ataacccgag tgatgaagca tcttcagata ttgtacaacc 134880
atttcgtttg gagcatcggt tgataattta tctaattcgt atgggccacg agatgtatga 134940
atagctagtg ttccatcaag atcaaagatt gccgcttttg gtttaccagg agtccctttg 135000
tataccggaa gaccgagata ctctcgcatg cttttataca ttgagcgtaa aacatcaatc 135060
ggtactgctt tagttccacg ttttgagtta cgtttaacta gctcagtcca aggaacatca 135120
aacactttat attcaacttt ccaaccgtat tctttggcaa aagtttccca tgctaggcga 135180
cgttcgggat tcaagttggt gtctgaaata attactccct tgacagaatc accgccatac 135240
aaaatactct tcgcggtatc aaactgcata ccggtcacaa tgccttcttt ctttttggta 135300
tacttatact cgtcacgctc ttcatgaccc atgatggatt gacgataatc atcacgatta 135360
atattataaa atccaggatt tttagcaata aattcacgag tccaagtact cttaccagaa 135420
ccaggacaac caatagtcaa aataatcttt ttcatcattt aattcctaag aaaacttcaa 135480
gaatacgaat attatgctca cgccgtcctt tgtataattc agctgttgat tgattcactg 135540
atttactctg aacattggat gaaataaatt ttatcatgtg atttttaagc tgatgcatat 135600
caagcccacg ggctttcgct tcttttcgca gggctttacc agcatcatct aaagctttag 135660
catgttcaat gtcttcgcta atgcttgata cattttcacg gcatgcgtca atgtaacggt 135720
ctgagcattc aatataacgt tctagtagag ttttcattta tttttctcaa ccaatgattg 135780
aatataatca tgcaggtctt tagatgcttt accccactta ttttggtatt catttttaag 135840
attagcacgt gattgagtta ataaaacatc attagttgga ggtaaagatt ctaatcgttg 135900
aatctggcgt ccataaatca ttgcagccat ctcggattca taaatcaatc ctttaagatg 135960
ttcaaattga tgccatgaaa tcatttacat ttatcctctt ttagctcttg acgataataa 136020
catatcatag ttttttggtc atgtacatat cgttttacat cattaagcca aatacgaaat 136080
tcctgggaat cttcaaatgg cataccaacc caagctttac catcaataac tttaacttgc 136140
caagatagtt tagcttcatc atatgacttt atctgcacag gccaattagg atgaactgtt 136200
tctttcttta cttctagagg ctttgtcgaa caaccaacta gaagaccaat agataatatt 136260
actgctgata gtttaatcat ttagaaaggt cctggatgtc ttctgcgaac ttgttgaagg 136320
agttgttgat ttgtttttca accaatcctg gcttatgagc caccacatcc gccttctttg 136380
cgtctttgcg cagtttttca ttttcacgct caatagcagc aattgcctca cgatttttat 136440
tattcatcgc atcaatataa ttatactgaa ttcgcaaatt atctaatgct aaagcgtttt 136500
cattggccgt ttttgtaatt tctacaacag acgtttctaa tctttcaatt ttacttttta 136560
aaattaaaga agttccgccc aatgcaatta caattaatag caagcctgct gtcgtattac 136620
ttaattgcat aaagttttaa taacctctat aatatcgtct tgagaaagac cgttaattaa 136680
aatatgatgt tcagccggag atttagaaat tttaaagcat gcctcaacat cttctgccat 136740
atccgatgca ctacgatttg gattactaat tccaagacga tgttttcccg tcaaaggatt 136800
aacaatgatg tagcatttac aattattgat atgaacatta ggttgagtct gattaatgaa 136860
cacatcacaa tcatatttcg caagctgatt ttctaaaaag actttcatct cttcaactgc 136920
atcaggaagc atatcacggg cttgctcaag acgacgattt cgatattctt taatggtcgt 136980
tttccgcttg acttgcttag ctaaatcttt cttaagatcg gtgatatatc caactcgacg 137040
atttccttta aatacagaaa tcccatctgt agtatcaccg tatgcttcaa cgaccatctc 137100
agtagtaata agctgcaaat ccatcataaa gtcctcatgt tatgtcagta agactactgt 137160
aacacatcac gagggacttg taaacagctt agtatccttc tgggataaat tttttataat 137220
ttttcaaaaa attctgttcg atttcacaca tgaccttctc ttgactatca tacccttggt 137280
agaggctcat gatgatacca aatagatgtt ccattccagc acctttagca acgccttgcg 137340
cttccatcgc ataagtcttt ctatctttac cgcaatgctt attgtgacag tcaagaacta 137400
aaaacaaagc tcggtctaag tacttcagat aagtcgtctc aaatgcttca atttttctgt 137460
atgaatattc atcgtcagcg tacattgctt taagatcatc tgatgcacca tcaataatag 137520
tcttaaacaa tttttctgga ttatctaatg aactttttgt gctgtgaaga gatacgtacc 137580
agtcagactt aattttaaaa tgagaaccat ctttcatcac agcaacatag ccttcgatgt 137640
tttctgcatt tttagcttct tctacccatt taggactatc aatttcgtat cgttcaacta 137700
gatatggacg aagaacagca tctttataaa tatcatcata tgaaatgtat tcgcctgttt 137760
cattttcacg aatattcaat aaaatgattt tcatctcttg ataagcaaga acgattctat 137820
tcgtcggagc aacgaattca aagttagcag taaatccatc ttcagctaat tctttaagtc 137880
tgtcgcgcaa ctgatgatga ttaatattca tcaaaatccc attagccatt aaagcttgtt 137940
cggatttgat tgaacccttt gatttgaaca gaatttcatc accatctaaa tatgttgata 138000
ccaaagaccc gtcttctttt gttagaatgt aatcaacatc atttaaatcg atattcatcg 138060
tgaatggatt ttcattcaag ttaaaaaact tttccatagg acgagaagcg attcttaccg 138120
gtttttctcc atccatttca aacataattc cacgacattc tagtgcgtct ggaagtaacc 138180
aatcagaata agatgcataa ttatatgaga aaattctgta agttcttcca gatgcactta 138240
catcatctga gtaaaaaaac ttacgctgcg aatccttaca cagctccatt aaattgttaa 138300
aaagttcttg cattgtgtat cctcttttgt gttttgaata tagtaccaca ctccatgtgg 138360
aagcatcatt ttttcttgtg ttgaatattc caaggcgggt taaacagttt aatgaatagc 138420
ggctcctcta ggtcaatcgt tgcgattgtc attgtaccta actcatttgt catagaaaga 138480
ttaaaacatt ggcgggcgta aaattcaact ttgcttcctt cctttagcgc agcatgaatt 138540
aatgcagatt tagtagaatc agacgttttg tctttacggt taatagcagt tctataatag 138600
tttattcttt tacgtaaatt tttagttttt ccaatataaa caagctcatc atttatggca 138660
atagcataaa ttacattata cttgtttgga atagataatt gttttatact tccattgtcg 138720
tctaattcta gctcagtata tttaataaat gaatattctg ttgcaatttc tttcataata 138780
aaatgggcct tgcggcccac tccttaaaaa tattttttaa aactcatcat aactttatca 138840
tcaacatcat tatcaatctg tgcaacaagg taagatgaca gttctacctc ttgcggcgct 138900
gattgaacat tatcagaatt aaggtattca cgaatccaag gatacggatg tttaaccgga 138960
gcatcggtaa ttgggcatgg aagaccacac tgtttcatgc gagatacagt taagtaatca 139020
ataaagctcc acatgctatt tgtatttaat ccaggaacat cgccatcttt aaataaatga 139080
actgcccagt ctttttcttg acggttaact tccatgaaaa tatcaactgc ttcttgttca 139140
cactcttgag caattttaac ccattcatca ccatcagtgc caagttgaag ttgacgaata 139200
atatattggg tgcctttaag gtgaagctgc tcatcacgcg caatgaactt cataatcttg 139260
gcattacctt ccatgatttc catgttctta tggaagttaa aggtacatgc gaaagataca 139320
taaaaacgaa tagcttccaa tgcgttgatt acatgcaggc agaggtaaag agatttcatt 139380
agtgctcgtt tagtacattc aacaactttg cctagctctt ctttacgaaa tccttctgat 139440
aaaattcctt cataatcttc aaccgcattc tgatattcac gagtcttaac tagaacgtca 139500
tcataataac gaccaataga ttcagcacgt ttcatgatag ctttatctaa tacaatctca 139560
tcaaatacct ttgatggatc agtataaaga tttcgcatga tatgagtata tgaacgactg 139620
tgaatagttt cactaaaagt ccatgtagca acccatgtat caagacttgg gtctgaaatt 139680
aatgacataa gtacagcaga cggtgcacga ccctgaatgc tatccaaaag tgattgatac 139740
ttcaggttat tagtaaaaat atcttgctga tactgaggaa gcttgttaaa ttgtgcagca 139800
tccatcatca agtttacttc ttcaggacgc cagaaaaatg ataattgctt ttcggttaaa 139860
tcttcaaaaa ctttatggcg ttgaatatca taacgcgcaa taccaagacc tgaaccgaag 139920
aacataggtt cttttaaaac atcaactgga tttgtattaa aaactgtgct cataaatttt 139980
ccgcttagtt aatagatagt gactcgtccg tgagtcaaat tatatcataa tttacaggat 140040
gaacaatctt cagcttttgg agtttctatt tcataatcat cagtaccaga accgtcacgg 140100
gtattatgat aatagaaatt ttttccgcca aaataccaaa aatacaaaag gtcatcaatc 140160
attattgaca ttggaacctt tccttttgga aaaatctgcg ggtcataata tgtatttgct 140220
gaagctgatt gacataccca tttaagcata atagctactt gcgtaagata aggtttatta 140280
cctttcttag ctaatttcca cgtataatca tagaggtcta tgttatgctc aatattgggc 140340
acgacttgat taaaggaacc ctcttttgat tctttaacag agactggtcc acgtggaggc 140400
tcgataccgt ttgtactgtt agaaacttgg gaagatgact cacatggcat aagtgctgat 140460
aatgtgctat tacggatgcc aaagagctta aggtcttccc gcagcgacga ccagtcacaa 140520
acgtattttg gagctgcgat ttggtcaatc tttttattgt accagtcgat aggtaattcg 140580
cctcgagacc aacgagtgtc tgaataatat tcgcaaggtc ctttttcttt ggcgagctta 140640
atggatgctt taatgagtcc atactgcaat ctctcaaata gttcatgtgt taaatcgtta 140700
gcatcttcat aagaagcaaa attacttgcc agccaagctg catagttagt aacacctacg 140760
ccgaggtttc gacgcttttt agctttttct gcttcaggaa ctggatatcc ttggtaatcc 140820
aaaagattat caagagcacg aacttgaact tctgccaatt cattaatttt atcttggtct 140880
tgccaatcga agttatctaa cacaaatgca gataacgtgc acaatccaat ttcagcatca 140940
ggactattca cgtcatttgt tggaatagca atttcacaac acaagttact ctgacgaata 141000
ggtgcctttt cacgaataaa tggagtatag ttattagtat tatcaatgaa ctgtacataa 141060
atccttgctg ttcctgagcg ttcagtcatt agcaattcaa acagttcacg ggctttaata 141120
cgctttttac gaatattagg gtctttttct gcggcttcgt ataattcacg gaaacggtct 141180
tggtctttaa aataagaata ataaagctca ccacccattt catgtggact gaacaaagta 141240
atgtagtcgt tctttccaaa acgttccatc atcaaatcat tcagctggac gccataatcc 141300
atatgacgga tacggttttc ttctacgcct ttgttatttt tcaaaacgag aagattttca 141360
acttccaaat gccaaatagg ataataagca gtagcagcgc cgccacgaat tccaccctgt 141420
gaacatgatt taacagcagt ctgaaaatgt ttccaaaaag gaataacacc agtatgacgt 141480
acttcacctg tgccaatctt agaaccttcg gcacgaatca taccaacgtt aataccaatt 141540
ccagcgcgtt tggagatata ttcaacaatt gaagcagaag ccttattgat agacttcagc 141600
gaatcacctg cctcaataac aacgcatgaa ctaaactgcc gagttggagt acggcaacca 141660
gccataatag gagttggtaa tgaaatctgt cgagtagata ctgcttcata aaaacgaata 141720
acatgtttta atctatcaac aggttcatct tgatgcagtg ccattccaat agtcataaat 141780
gcaaactgcg gagtttcata aatttgacca gtggttttat ctttaactag atatttttct 141840
tttaattgca tcgccccgga ataagtaaat tccatatccc gctcatgctt aatttttgat 141900
tctaaaaatg taatttcttc tgctgaatat tttgacaaca gttcagggtc atatttacct 141960
tcatttacac agtaagaaat atggtcaata aatgaacgtg gttcatactg cccataaaca 142020
tgcttacgaa gagcaaacat taaacagcga gcagctacgt attgataatc aggctcttca 142080
actgaaatag aattcgcagc agccttaatg acaatggttt gaatgtcatc ggtggtcatt 142140
ccatcacgga gatatgattt aatattttca tataattcat aaggatctac agatgttcct 142200
tcagctgccc aagataaaac tttaataatt ttttgcgggt caaagctctg agaaacacca 142260
ctacttttga taacattaat taattgcata agtcctcaac ttgaaaatcg tctttaaaca 142320
atcggttaac tatatgagct attatatcac catgacacgg ctttggttta catgtgcatc 142380
ctagcctcat tccacgtaaa ggctctaaat gtgctttagt tatttctccg gatttaattc 142440
gacgtataaa atcttttttg aataattcaa tggcagcctc ccggctgcca gcatctttac 142500
cgacgtaatt tccccaaaat gtaccacggt gaatattaac atcaaagtcg gatttatatt 142560
tattcactac ccggcataga cggcccgtgt ggtaataatt cgtcatattg ttgttccgtt 142620
aaaacagtaa tatcataata acaatcagaa gaagttttaa ctgtggaaat tttattatca 142680
aaatactcac gagtcatttt atgagtataa tattttttgc cataaatgat aataggctgt 142740
tctggtcctg gaacttctaa ctcgcttgga ttaggaagtg taaaaagaac gacaccagaa 142800
gtatccttaa atcgtaaaat catatatcct ctcaattaaa ttaaaattac accgccatct 142860
ttcctttaat aggagggtgt gattcgtaac ctttaagaac gaaatcttta ggcctgagtt 142920
taagaacata ttccaattgt tctttagcag aaagatagcg gaatttataa ggcaatccgc 142980
ctattaccag ttcacaaagc tctttaggtt cacgacgcaa aatttcttta cattgttcta 143040
cgtgattcat atagatatga gtattaccgc cagaaaatat caaatctcca ggaataagat 143100
tacacatctt agctacaata tgagctaacg cagcatatga tgcaatatta aacggtagca 143160
ttatgttcag ataaggtcgt taatcttacc ccggaattat atccagctgc atgtcaccat 143220
gcagatcaga ctatatctcc aacttgttaa agcaagttgt ctatcgtttc gagtcacttg 143280
accctactcc ccaaagggat agtcgttagg catttatgta gaaccaattc catttatcag 143340
attttacacg ataagtaact aatccagacg aaattttaaa atgtctagct gcatctgctg 143400
cacaatcaaa aataacccca tcacatgaaa tctttttaat attactaggc tttttacctt 143460
tcatcttttc tgatatttta gatttagtta tgtctgaatg cttatgatta aagaatgaat 143520
tattttcacc tgaacgattt ctgcatttac tacaagtata agcagaagtt tgtatgcgaa 143580
caccgcactt acaaaactta tgggtttctg gattccaacg cccgttttta cttccgggtt 143640
tactgtaaag agctttccga ccatcaggtc caagtttaag catcttagct ttaacagttt 143700
cagaacgttt cttaataatt tcttctttta atggatgcgt agaacatgta tcaccaaacg 143760
ttgcatcagc aatattgtat ccattaattt tagaattaag ctctttaatc caaaaatttt 143820
ctcgttcaat aatcaaatct ttctcatatg gaatttcttc caaaatagaa cattcaaaca 143880
cattaccatg tttgttaaaa gacctctgaa gttttataga agaatggcat cctttttcta 143940
aatctttaaa atgcctcttc catctctttt caaaatcttt agcacttcct acatatactt 144000
tattgtttaa agtattttta atctgataaa ttccgctttt cataaatacc tctttaaata 144060
tagaagtatt tattaaaggg cagtcctaca atttagcacg ggattgtcta ctagagaggt 144120
tccccgttta gatagattac aagtataagt caccttatac tcaggcctca attaacccaa 144180
gaaaacatct actgatcgtt gataccactg caaatccaaa tagccattac gcacattaaa 144240
ctgatagaac atatgacaag gtggtaatgc catctgcttg agttcagctg gattccatgc 144300
cgacacaatt tgacgtctat cattgggaaa tgttttaata cgattaacaa cttctacaat 144360
ttgatctaca ccaccaaaat cacgccactg ttttccgtaa attgggccaa gttcaccgct 144420
atgataacct aagtctttag cctggttttc gtagttttca tcccaaattg tttttcctgc 144480
aattaaagat ccatgagtac gttgacgtaa atcatttacg ttagtacttc ctgataagaa 144540
ccacaataac tcagaaatac atgcattcca ggcgagcttc ttagttgtta ctgcaggaaa 144600
acctttactt aaatcccagc gtaatttagt accgaacaaa gcaattgttc ctgtgcctgt 144660
tcggtcatcg gtttcatagc cattttcaaa aatgtcttta attaaatctt ggtattgttt 144720
catttagtac cttatataaa ttataataca ttttatgaag ctaataatca atacggttta 144780
gcatcaaatt ttctttcgat ttcaggagtg aaatataatt ctttaccacg tttggaaaaa 144840
cgaccaataa tatgataatt attctcatca aacgtgatat tgccaatatc catagctttc 144900
aaccaaatat cgatatttct atctagtttt atatcaaaat tccaatacgg agaactatta 144960
ccaaaaatac tacaagcgga ttcagtgaaa caactgctat aaatcttgtc tttaggaact 145020
actaattgat agacgccttt aataaactga ggaccctgcc attttggttg tttcgcgtct 145080
ttttctaata gaatagggta ataattaaag ttcatatttt ctgccacgcg ttatttcatt 145140
tatatactga ttccgtaagg gttgttactt catctatttt ataccaatga ctttcaacca 145200
tttcacgctt gcttatatca tcaagaaaac ttgcatctaa ttgaaccgtt gaattaacac 145260
gatgcctttt aacgatgcga gaaacaacta cttcatctgc ataaggtaat gcagcatata 145320
acagagcggg tccgccaatt acactaacat tagaattctg gtcaagaata gtctcgaatg 145380
gagaaccaga aattgatact tgaatttcgt cgccggaaat gtaatctata tattgctccc 145440
aagtaatata gaaatgtgct aaatcaccat ctttagtttc aggataatca cgcgcaaggt 145500
cacacactac aatatgtcta cgaccaggaa gtaatgtagg caatgactgg aacgttttag 145560
cacccataat cataatcgtg ccttcagtac gagctttaaa attctggagg tcctttttaa 145620
ctcgtcccca tggaagtcca tcacctaagc cgaatgctaa ttcattaaag ccttcgaccg 145680
ttttagttgg agaataagcg aataccaatt taatcattac gcaaaacccc tttcaataaa 145740
ccattcagtg gctttattag cgtcaaagaa taattcttca tatgtctttt ctttgttttc 145800
aaagactgtc acacaaacac gttgacattc tccacagtat tcttctgaca tactcaaagc 145860
gtcagaaaac atttcattaa attcatttaa atcaggatta tgcaatgcgt taaaaattgc 145920
ataatcgaat tcatcattca taaattcaaa tacaaaaatc atattatctc ctaatataaa 145980
ggatcgggaa catatccact ggctttaatc attttgatta acgttagcag tcctttatta 146040
actgcttgtg agatttcatc aaaaacttca tcactaaaaa gttctaacac tcccttctga 146100
acttttaatt tacaaccaac aatttcgtca tcgcctatag taaattcgtt tccgccaatt 146160
ccaccgaaaa acttaattac accagttaac tgtgttccac gagaatatgg gtcgtgtgat 146220
aaagtaatat gagtcacccc aggtacagtt ttaaattggc agcgaatgtt tacttgggca 146280
attccagtta cgtgaatgtc agacataata ttttcctcaa acagactttt tcacaatttt 146340
ccaatcagct ttaaactgat cgacgtcaga atggtaaatc cagaatcctg cgctttctcc 146400
atcctcataa agagggcatc catcacattc atcttcccat cccatatcac gtaaaagatg 146460
ttcagctttt tcaacaagtt cagaatcttt accgatgata ttaaaatacc atttaccttt 146520
aacttctgaa tctttgatgc tctggcgttg taatctcatt ttattctcct tagttgatag 146580
ggtaatagta tcacactact accctactgt aaactacttt ttgaaagttt ttcgtaaaag 146640
ttcaatgatt tcatctacat tgttttcgtc aacaatgcag tgaatttttg ttacgccaga 146700
aaccttgtct tcgatttcat cttcttcaga agtcggttct ttatactcac gaaaacaatg 146760
aaattcgtct tcgcaaattt ctaaaagtct atctttgaga taaaaatgct ttccatttgc 146820
acattcaatg tgttttactg ctttgtatcc attggcgacg gaaacttctt taacttcaaa 146880
ccatccgcca ttatctcgaa tagctttaac tattgatgaa ttagaacgtg gactataatt 146940
aataaatgta tcaataagtc ttggaacaag ttcatacttt ctaccagtat acattgcgtt 147000
ttcctcattt taataggggc ttgatagccc cttgataatt actgctcaat aaatccagtg 147060
taaaattcta catcttcagc atccataccg tcacaatatt cattaaccat aaattgttta 147120
agacgattta aaggaccttc aataacaact gaaacattgc agttaggatc atttagtgcg 147180
cttgtaatac ggagttcagg ataacgatta cgaataattt cttcaatata ttcaaaatca 147240
acaacatcaa tatcaatttt agccatgtta ttttcctctt taatcatcat cagcagtatt 147300
gccgatagtt gtatagtacc atagtccttg ttgtatgtaa actgttttgt gaaaaaattt 147360
ttgaaataaa aaaggggacc tctagggtcc ccaattaatt agtaatataa tctattaaag 147420
gtcattcaaa aggtcatcca ggtccgtgtc atcagcacta gatgaactgc cagagcttga 147480
gctcataaaa tcatcttcag tttttgtttt gaagtcatca acattaaatg catccaaatc 147540
atcagcaact ttatcagctt tcttagcggc agaagctgcg gcaccaccca tagcagcagt 147600
tcccataact tgactgaact tagtgctcag ttcttcaaac gatttgaatt tatctttaga 147660
agtcatttca gaaaggtcaa ccatttgttc gaacagttct ttctggaaag attcatcatc 147720
aatgtttgga atcgcagatt gattcaggaa tttagattcg tcgtagttac taaaaccaga 147780
aacttgttta actttcagta caaagttagc accttcccac ggacaagtta catcaaccgg 147840
agtttcaccc atttcaacat caactgcaat cattgcattg attttatccc agattttctt 147900
accgaaacgg tatttaaata ctttaccttc attttctgga gcagctgggt cttttactac 147960
aagaatgtta gcccagtaag aagttttgcg tttaacaaga ccgtactctt tattgtcagt 148020
gttatacaaa tcatttttac tgatgtactg acatactgga caagaatcgt aatcaccgtg 148080
ggtagatgaa cagttttcaa tataccattt accatttttc ttgaaaccgt gatttacaag 148140
aattgcaaat ggtgcttgtt catcattttt agacggaaga aaacgaatta ctgcttgacc 148200
gttacccgca ttatcgagtt tcagtttcca ctcgccttta tcttcagaag aaaaaccgcc 148260
tttatttcca gccagtttag ccatttgcgc agcgagttca gcagtagatt tacgtttaaa 148320
catttttatt tcctttttaa tttaattaac agttggtgct atgacgatgt atgacctcat 148380
agctggtcag tgagataatt ataatctatt tataataagc aattaatact tgcaagattt 148440
cacagtttca ataaaaacac ttttagcttt ctgtgaatca atatttaaaa tttttctata 148500
agcctttaac tttatagaat aattattcca gactaaatta tcagtctgtt catcatgttt 148560
atcgattata tttaaaaacg aatcaagcaa gataaacgtc tcaaacgaaa ttatattcga 148620
ttgaagtagt ttaaaaatat aacttgattg aacttttgga ttatactcaa agatttcttt 148680
aaaagcagaa acttcaactt ttttactaaa ataataaatg ttgcgaatat cttcttcaaa 148740
cttaaattta atttgcttta agcgtccgat atattcacga taaaacacaa gtgcatcagc 148800
gtcagagatg tcaccaatcc aagcatcttg gttagcaacc agattgctta taaagattaa 148860
agcaagttcc tttaatttat atttttctga taacttctgg aaaaaatact tatcccttcg 148920
cttttgataa gcggcatcag acacccgcat gcaccaatta tacttaatta catcatactt 148980
tccattcata tgttgtttta tcattaagta taatttataa actgatttac catcaatata 149040
tctttcacca ccagcaggca tgcggagttt aatcatagta gaaaatctaa tgtattagtt 149100
ttttcacaac gaacaacaga aggacgtaaa agattttcgt caatagcttc tgactgaatt 149160
ttttcaatta tacccgaagg aataaattta gcaaattgag tttcaggaat agaattttct 149220
tctaagaatg ctgttgtagc ttcaagataa ctcattccaa actcttctac cattttttca 149280
atgataaatc cattttcttg acgatcaaga agctttgcta tttcatcctt ttctttctta 149340
attgaaagtt ctttttctga aagaccggtc tcatcgaccg gacgaatatc atttagagaa 149400
aactgtgtca taaagttcaa ctacctcttc agtttcagct tcaaacacat cacggttatc 149460
tttatgatac aaagctaata gacgattaaa catcttacca tcaacgccaa gttcatcttt 149520
agcacgaatt cgaatatctt taatcaattc attataacca gaaattttca gtttatgatc 149580
agatgcttct ttgataaatt tggccaagtc ttcgccatgg atagcttcat caaattcaac 149640
catttctttt ttagccatta ttcacctcaa aattcattaa tgctattagt taatttagaa 149700
agacccgctt ttacaaaata tgaataaatt ttgccacgcg gtggtaattt atatgaatta 149760
tagtaattca cgatgtttga agcaatatta tcaggaatat aatcaaaatc aattagaact 149820
aaattttctt tatatcgatt atattcagat tcagtgagaa gcaccttagc ttgctcacgg 149880
tcattagcaa tagcttcaac aatagaggtt ttcattgaag gagttcgttc accttcaact 149940
ctggtaaacc aaaagtcaga tcgtacttta actgaagcga cgttatcctt tttatcaccc 150000
ttgagaattt tagtcataca gtcaatttca gcagaaccgc ttttaatttt aacccatttc 150060
ttatgcatcg gtgaccattg cttaacattt ggatatttgt gaagttgagt aaagtcacca 150120
tccgatgaaa tgattaaaat tttatgtcct tctaaagaga actttttaac aagaacagca 150180
atatggtcat ctgcttcata cttatcaata tccataacaa tatatggcat ataagctttc 150240
aattcatcta taactttatg actggattca aaataacctt cccagtccca agtagattct 150300
tctcgtgctt ttccacggtt tttcttataa taataagcaa aatcacgacg ccagtatcca 150360
gatttcgcgt tatcaataca caatacaatt ttagtgtatc caagagtttt tgcttttttg 150420
acattaaact taattgagtt caatatcaaa tgacgaacca tcgataaatt aattttttct 150480
ttatctggga agtttactag agcagttgaa agcgcaattt gactaaagtc aattaagcag 150540
attccttctt tgtaatcttc atccagcatc atttctaaat ccatatgaac ctcgttcaat 150600
tagtgagatt tctattatat accatccaaa tcttaaagta aacaagtata aatacttatt 150660
attgaaaaca caataggagc ccgggagaat ggccgagatt aaaagaaagt tcagagcaga 150720
agacggtctg gacgcaggtg gcgataaaat aatcaacgta gctttagctg atcgtaccgt 150780
aggaactgac ggtgttaacg ttgattactt aattcaagaa aatacagttc aacaatatga 150840
tccaactcgt ggatatttaa aagattttgt aatcatttat gataaccgct tttgggctgc 150900
tataaatgat attccaaaac cggcaggagc ttttaatagc gggcgctgga gagcattacg 150960
tactgatgct aactggatta cagtctcatc tggttcatat caattaaaat ccggtgaagc 151020
tatttcggtt aacactgcag ctggtaatga tattacattt actttaccat ctactccaat 151080
tgacggtgac actatcgttc tccaagatat tggaggaaaa cctggagtta accaagtttt 151140
aattgtagct ccagtgcaaa gtattgtaaa cttcagaggc gagcaagtac gttcagtact 151200
aatgactcat ccaaagtcgc agttagtttt aatttttagt aatcgcctgt ggcaaatgta 151260
tgtcgctgat tatagtagag aagctgtagt tgtaacacca gcgaatactt atcaagcgca 151320
atccaacgat tttatcgtac gtagatttac ttctgctgca ccgattaata ttaaacttcc 151380
gagatttgct aatcacggcg atattattaa tttcgtcgat ttggataaat taaatcctct 151440
ttatcataca attgttacta catatgatga aacgacatca gtacaagaag atggaactca 151500
ttccattgaa ggccgtacat ctattgatgg tttcttgatg tatgacgata atgaaaaatt 151560
gtggagattg tttgacgggg atagtaaagc acgtttacgt attataacaa ctaattcaaa 151620
cattcgtcca aatgaagaag ttatggtatt tggtgcgaat aatggaataa ctcaaacaat 151680
tgaactccag cttccaacta atatttctgt tggtgatact gttaaaattt ccatgaatta 151740
catgagaaaa ggacaaacag ttaaaatcaa agctgcaggt gaagataaaa ttgcttcttc 151800
agttcaattg ctgcaattcc caaaacgttc agaatatccg cctgaagctg aatgggtgac 151860
tgttcaagaa ttagttttta acggtgaaac taattatgtt ccagttttac aacttgctta 151920
tatagaagat tctgacggaa aatactgggt tgtgcaacaa aacgttccaa ccgtagaaag 151980
agttgattct ttaaatgatt ctactagagc aagattaggc gtaattgctt tagctacaca 152040
agctcaagct aatgtcgatt tagaaaattc tccacaaaaa gaactagcaa ttacaccaga 152100
aacattagct aaccgtactg ctacagaaac tcgtagaggt atcgcaagaa tagcaactac 152160
tgctcaagtg aatcagaaca ccacattctc ttttgctgac gatattatca tcactcctaa 152220
aaagctgaat gaaagaactg ctacagaaac tcgtagaggt gttgctgaaa ttgctacgca 152280
gcaggaaact aatgcaggta ctgatgatac tacaatcatc actcctaaaa agcttcaagc 152340
tcgacaaggt tctgaatcat tatctggtat tgtaaccttt gtatctactg caggagctac 152400
tccagcttct agtcgtgaat taaatggtac aaacgtttac aataaaaaca ctaataattt 152460
agttgtttcg cctaaagctc tggatcagta taaagctact ccaacacagc aaggtgcagt 152520
aattttagca gttgaaagcg aagtaattgc tggacaaagc caagaaggat gggcaaatgc 152580
ggttgtaacg ccagaaacgt tacataaaaa gacatcaact gatggaagaa ttggtttaat 152640
tgaaattgct acgcaaagtg aagttaatac aggaactgat tatactcgtg cagtcactcc 152700
taaaacttta aatgaccgta tagcaactga aagtttaagt ggtatagctg aaattgctac 152760
acaagttgaa ttcgacgcag gcgtcgacga tactcgtatc tctacaccat taaaaattaa 152820
aactagattt aatagtactg atcgtacttc tgttgttgct ctatctggat tagttgaatc 152880
aggaactctc tgggaccatt atacccttaa tattcttgaa gcaaatgaga cacaacgtgg 152940
tacacttcgt gtagctacgc aagttgaagc tgctgcagga acattggata atgttttaat 153000
aactcctaaa aagcttttag gtactaaatc taccgaatcg caagaaggtg ttattaaagt 153060
tgcaacccag tctgaaactg ttactggaac gtcagcaaat actgctgtat ctccaaaaaa 153120
tttaaaatgg attgtacaga gtgaacctac ttgggcagct actactgcga taagaggctt 153180
tgttaaaact tcatctggtt caattacatt cgttggtaat gatacagttg gttcaacaca 153240
gtcgttagaa ttatacgaga aaaatagcta tgcagtatca ccatacgaat taaaccgtgt 153300
attagcaaat tatttgccat taaaagcaaa agctgctgat acaaatttat tagatggtct 153360
agattcatct caattcattc gtagggatat tgcacagacg gttaatggtt cactaacctt 153420
aacccaacaa acgaatctga gtgcccctct tgtatcatct agtactgcta cgtttggcgg 153480
atcagtttcg gcaaacagca cattaactat ttctaatact ggaacggcaa ctcgtctgat 153540
ttttgagaaa ggacctcaaa ctggaactaa cccagtacag acgatgacta tcagagtttg 153600
gggaaatcag tttggtggcg gttcagatac aacacgttct actgtatttg aagttggtga 153660
tgaaacgtct aatcactttt attctcaacg taataaagct gggaatataa cgtttagtat 153720
caatggtact gtaatgccaa taaatgttaa tgcttcgggt tctttgaatg cgaacggcgt 153780
tgcaacattt ggtagctcag ttactgctaa tggtgaattc atcagcaaat catcgaatgc 153840
ttttagagct attagtggta attacggatt ctttattcgt aatgatggtg ctaatgtcta 153900
ttttatgctt actgcatcag gtgatcagac tggcggattt aatggattac gtcctttagc 153960
tattaacaat gcatccggtc aagtaacgat tggtgaaggc ttaatcgttg ccaaaggtgt 154020
tactataaac tcaggtggct taactgttaa ctcgagaatt cgttctcagg gcattaaaac 154080
atctgactta tatacccgtg cgccaacatc tgataccgta ggattctggt caattgacat 154140
taatgattca gctacttata accagttccc aggttatttt aaaatggttg aaaaaactaa 154200
tgaagtgact ggacttccat acttagaacg tggagaagag gttaaatctc ctggtacatt 154260
gactcagttt ggtaacacac ttgattcgct ttaccaagat tggattactt gtccaacgac 154320
tccagaagca cgtaccactc gctggacacg tacatggcag aaaaccaaaa actcttggtc 154380
aagttttgtt caggtatttg atggaggtaa ccctcctcaa ccatctgata tcggtgcttt 154440
accatctgat aatgctacaa tggggaatct tactattcgt gatttcttac gaattggtaa 154500
tgttcgcatt gttcctgacc cagtgaataa aacggttaaa tttgaatggg ttgaataaga 154560
ggtattatgg aaaaatttat ggcagagttt ggacaaggat atgtccaaac gccattttta 154620
tcggaaagta attcagtaag atataaaata agtatagcgg gttcttgccc gctttctaca 154680
gcaggaccgt acgttaaatt tcaggataat cctgtcggaa gtcaaacatt tagcgcagga 154740
cttcatctaa gagtttttga cccttccacc ggagcattag ttgatagtaa gtcatatgct 154800
ttttcgactt caaatgatac tacatcagct gcttttgtta gtttcatgaa ttctttggcg 154860
aataatagac ttgttgctat attaactagc ggaaaggtta attttcctcc tgaagtagta 154920
tcttggctaa gagccgcagg aacgtctgct tttccatctg attctatatt gtcaagattc 154980
gacgtatcat atgctgcttt ttacacttct tctaaaggag ctattgcatt agagcatgtt 155040
aaattaagta atagaaaaag cacagatgat tatcaaacta ttttagatgt tgtatttgac 155100
agtttagaag acgttggagc tacgggattt cctaaaagaa catatgaaag catcgagcaa 155160
tttatgtcag cggttggtgg aactaataac gaaattgcgc gattgccaac ttcagctgcc 155220
ataagtaaat tatctgacta taatttaatt cctggtgatg ttctttatct taaagctcag 155280
ttatatgctg atgccgattt actcgcgctt ggaactacaa atatatctat ccgtttttat 155340
aatgcatcga atggatatat ttcctcgaca caagctgagt ttactggaca aactgggtct 155400
tgggaattaa aagaagatta tgtagttgtt ccagaaaacg ctgtgggatt tacgatatac 155460
gcacagagaa cagcacaagc tggtcaaggt ggcatgagga atttaagctt ttctgaagtg 155520
tcaagaaatg ggggtatttc gaaacctgct gaatttggcg tcaatggcat tcgagttaat 155580
tatgtctgtg aatctgcttc acctccggat ataatggtac ttcctacaca agcatcgtct 155640
aaaactggta aagtgtttgg gcaagaattt agagaagtat aaattgaggg agccttcggg 155700
ttcccttttt ctttataaat actattaaaa taaaggggca tacaatggct gatttaaaag 155760
taggttcaac aactggaggc tctgtcattt ggcatcaagg aaattttcca ttgaatccag 155820
ccggtgacga tgtactctat aaatcattta aaatatattc agaatacaat aaaccgcaag 155880
ctgctgataa cgatttcgtt tctaaagcta atggcggtac ttacaccgcg actgttcgat 155940
ttaatggagg cgtacatgtt cctactatag gtagtagtca acagtgcggt gtttatccag 156000
gtaacggtga tgcagctact tttgctatgg caaatattga catcgtttcg tggaatggta 156060
ttggttttaa atcatcacaa ggttcagcag accgaactgt tgtaattaat gcacgtaatg 156120
gtgatattag tacaaaaggc gttgtgacag cagtaggtca aataagaagt aatgcagttt 156180
ctcctgtatc agcaaatgat ctcacaagaa aagattatgt tgatggagca ataaatactg 156240
ttacggcaaa tgcgaactct agagtgttac gatctggtga cactatgacg ggaaacttaa 156300
ccgcaccaaa ctttttctcg cagaatcctg catctcaacc ttcacatgtt ccacgatttg 156360
accaaatcgt aattaaggat tctgttcaag atttcggcta ttattaagag gacttatggc 156420
tactttaaaa caaatacaat ttaaaagaag caaaaccgca ggtgcacgtc ctgctgcttc 156480
agtattagcc gaaggtgaat tggctataaa cttaaaagat agaacaattt ttactaaaga 156540
tgattcagga aatatcattg acttaagcat ttctgctggc ggtaatatca gtggaaatat 156600
cactcaaact ggtgattata cacagactgg aaaatttaat ttaattggtc cgcaaattgt 156660
agcaagcggt ggatatattg agtttaatta tcgtactact ggaagcgggg cttggtccgg 156720
tcaacacact gcaaaagctc caatttttgt agatttaagc tcagctactt ccacatctga 156780
atataatcct ataattaaac agcgctttaa agatggaact ttttcattag gtactttagt 156840
ttctgaaggt tcgttgaaga ttcattatat caatgaatct ggtgattcga aatattggac 156900
gtttcgacgt gacggtggat ttactgttga cggtggaggt ttagccgtat caggaggtag 156960
tataactaca tctggaaaca tcgccgcgtt cggaaatatc acttcacccc aaattaatac 157020
taaaaatatt attttagata caaaagcatt cggacaatat gattcacaat cattagttca 157080
atatgtttat cctggaacag gcgaagaaaa tggtataaac tatcttcgta aagttcgagc 157140
taaatcaggt ggaactattt accatgaaat tgcttctgcg cagactggta agaatgatga 157200
aatttcttgg tggaccggaa actcgcttac cactaaatta atgggtcttc gtaatgatgg 157260
cgcaatggta ttacgtcgtt cgcttgctat tggcacaatt accactgatg aaaatactaa 157320
caattatggt tctcctactc caatgggaga aagatatatt gctttgggtg atgctgcaac 157380
cggtttaaaa tatattaagc aaggtgttta tgatttagta ggtaattgga attctgttgc 157440
ttctattact cctgacagtt tccgtagtac tcgtaaagca ttatttggac gttcagaaga 157500
ccaaggcgga acctggacaa tgcctggaac gaacgctgct ctcttgtctg ttcaaaccca 157560
ggcagatgtg aataacgcag gcgatggtca aacccacatt ggatataatt ctggcggtaa 157620
attttcccat tatttccgcg gtaaaggcca aaccaacatt aatacacagg aaggtatgga 157680
aattaaccct ggtattttga aattggtaac tggctctaat aacgtgcagt tttatgctaa 157740
tggaacagta tcttcaatac aaagaattaa atttgataac ggattagttc ttactggtgc 157800
tagacctgac ggtattcaac ttgacgctcc tacatcagca gatggcacta aaactatact 157860
gtgggctggt ggtactcgcg caggtcagaa taaaagttat gtatctatta aagcgtgggg 157920
taattcattt aacgcatctg gcgatcgtgc tcgtgaaaca gtttttgaag tggctgacgg 157980
gcagggatat tatttttatg cacaacgcac tactcctgca tcaggtcaaa cagtaggtcc 158040
ggttaacttt aaatttaacg gaactgtcga aacaggccat atcataggcc ttggaaatat 158100
aagtgcctcc ggtacaggtt cttttggtgg caatgttacc atgtctaacg gtttgtttgt 158160
ccaaggtggt tcttctatta ctggacaagt taaaatcggc ggaactgctg atgcattaag 158220
aatttggaat gccgaatatg gtgctatttt ccgtcgctca gaaagtagtc tttatattat 158280
cccgactcct aaagatgccg gagaatcggg cggtataagt aatcttagac cattgacaat 158340
agaactgaac actggtacag ttaaaatgtc gcatgatgtt catttaggag attctggatc 158400
tggtacagga ttattacaag taagtaatag tcttaaaact attaaaatga tatgtccagt 158460
aactattaat gaacgtaatg cagcgcttac tctagattct ccttcatctt cttctgctaa 158520
ttatttacaa ggttctaaag ctggaattag atcgtggtat gttggtcttg gtggcgctgg 158580
aagtgattta tcgctttata gtcaatctta tggacacggt cttgttataa gcgataattt 158640
cgtgtcaatc agtaaacctc ttaaagttgg aaatgcccaa ctaggaactg acggtaatat 158700
taccaacggt tctggtaatt ttgctaactt aaacaccacg ctaaatcgta aagttaattc 158760
tggatttatt acttatggag caactgctgg atggtataag tttgcaacag taacaatgcc 158820
acaatccact tctacggtct tctttaaaat agccggtggt tctggattta atagtggatt 158880
attcacacaa tgcaatattg ctgaaattgt tttacgtact agtaataaaa gacctgctga 158940
cttaaatgct gtattataca caagaacatc tggaatgtat agcgcagcat ttagaaatat 159000
ttcagttaac aacgtctctg gaaatacata tgacatttat gtttatgctg gaacatattg 159060
taatcaatta gtttgtgaat ggtcatgtac cgaaaatgct actgttagcg ttattggtat 159120
taactcatct acccaatcac cggtggatgc tcttccagat acagcagtcg atgggcaagt 159180
tgctaatgtt cttaataatt tagttgatcg tggcaaagtt aagcgcttcg aagctgattc 159240
tgaaatagct attaataacc aaactggcat tcgtattaga agcaacggcg ataaaactgg 159300
ttctgttgct acaatgctac gaaatgatgg tggtagtttt tatattctgt ttacagataa 159360
aaatgccacc gatggcgcag caaccgttaa tggtggttgg aatagtaaac gtcctttcgc 159420
aattaactta acaaccggcg aagtgctaat gaataacggc atagctgttc gcagcgcagc 159480
tttattctat aatagtataa atgtcaaaga taatggttct attaactttg ataaatcagg 159540
tgctaacccg agaaatatga gaatatttca tgctggcgat gcttctcgcg gtaaccgtat 159600
tgaaattgcc gatgaaacta actatattgc ttactttgaa aaagctccag gtggagctaa 159660
ccgctttgta gtaaataatg ctactgtagc tggtgttaac caaatgaatt catttggtat 159720
taatatcaat aacgcacttg gtggaaatag tatagcattt ggtgatagcg ataccggtat 159780
taagcaaaat ggtgatggat tattagacat atatgcgaac agcgtacaag tattccgttt 159840
ccaaaacggc gatttgtact catataaaaa tataaatgct ccaaacgttt atattcgttc 159900
tgatattcgt ttaaaatcca acttcaaacc tatcgaaaac gcacttgata aagttgaaaa 159960
acttgacggt gtcatttacg ataaagctga atatatcggt ggagaggcaa ttgaaactga 160020
agcgggtatt gtggctcaaa cgttgcaaga cgttttacca gaagccgtcc gtgaaacaga 160080
agatagcaag ggtaataaaa tactcactgt ttcttctcaa gcccagattg ctcttctggt 160140
tgaagctgtg aaaacacttt ctgctcgtgt aaaagaactt gaatctaaac ttatgtaaaa 160200
gagggcttcg gccctctaag gatttttaat ggcaattgta ggtgttcctg gctggattgg 160260
tgaatctgcc gtgaatgaaa ctggacaacg ttggatggat gctgcgatga aagcagttcg 160320
tgtttcagtt ccaggttgga tgagctcaat ggcaggacaa tctaaagaag tatattacag 160380
cattggcgct agtaattctt acaataaaga cacattgata aattggataa aagcccaagg 160440
aagtactcct gttgttatta caattacagg caatatcgtt tcttcatcga caggtcaacc 160500
atgcttagat tttcctagct cattaactaa tgcatacgtg acacttaata tcaattcagg 160560
cgtgcatgtt tggggtcgcg gcgggaatgg tggaaataac tctgctggtg gagcaggagg 160620
aactgcaata aataacggaa ttggaactag attacgtatt aataacaatg gtgttatcgc 160680
aggcggcggc ggtggcggtg gcggcggata ctactctcct ttttcacaaa tgagattgac 160740
ttttggcggc ggtggcgggc gtccatttgg cgctgctggt ggttctgcta atatgaaaca 160800
aggtgctacc gctggtacta tttctgcacc cggtaaaggg tctgtcaacg gtatctataa 160860
tggcgggaac ggtggtgatg ccggtgctgc aggaggtaaa tgtaatattc gcggtcaagg 160920
atcagaatat aacggcggcg ccgctggtaa agctgttact ggtaatgctc caacttggac 160980
taaagttggt acaatatatg gtgcaagagt ataattttga ataaatatcc ttaaaaggag 161040
ggtctatggc agcacctaga atatcatttt cgccctctga tattctgttg ggtgttctag 161100
atcgcttgtt caaagataac gctaccggga aagttcttgc ttcccgggta gctgtcgtaa 161160
ttcttttgtt tataatggcg attgtttggt ataggggaga tagtttcttt gagtactata 161220
agcaatcaaa gtatgaaaca tacagtgaaa ttattgaaaa ggaaagaaat gcacgctttg 161280
aatctgtcgc cctggaacaa ctccagatag ttcacatatc atctgaggca gactttagtg 161340
cggtgtattc tttccgccct aaaaacttaa actattttgt tgatattata gcatatgaag 161400
gaaaattacc ttcaacaata agtgaaaaat cacttggagg atatcctgtt gataaaacta 161460
tggatgaata tgcagttcat ttaaatggac gtcattatta ttccgactca aaatttgctt 161520
ttttaccaac taaaaagcct actcccgaaa taaattacat gtacagttgt ccatatttca 161580
atttggataa tatctatgct ggaacaataa ccatgtactg gtatagaaat gatcatataa 161640
gtaatgaccg ccttgaatca atatgttctc aggcggccag aatattagga agggctaaat 161700
aattatttgt ttgtatacat ctctagatat cgatatacac cctcaaaacc ctcgttgaat 161760
tcgtcgatga gggttttctt atcttcttgg gttaattcag aaacaatttt acggaatgaa 161820
ttctgattta attttctacc ttcatgcgtt actccaatct cattcagaaa tgcaataaaa 161880
ttagcacgat tctcaacaat atcttctctg gaaaatttaa tcaaaataga cgcaacagta 161940
ataatttcac gaactgtatc aatgttttta ttcattaact ataccactca attagttgac 162000
tttattataa tatcatcaga cgtttgattt gtaaactggt ctgtgttatt ttcttcaaaa 162060
attttttcta cgaattcctt gaacgactca cgttcctgag ctacattatg ctcgattacc 162120
atttcaagat tatgactcat tcgaaataat cttcaatttc gtaatcatgg acataaaaca 162180
ttatagtttt taatacatca tcaatacttt ttcctggagc tggaattacg taaaaatatc 162240
ctgcttttga gaggtcttta taagttccaa ccaagaaatc attattctcg agatgtaatt 162300
cttcaactaa ttcattaaca attgaatggt ataaatttgg tagaaactta tatagctttt 162360
ctagaatatc aattttgatt gtatattgaa ccacagactg agaatcaata atcatagacc 162420
ttccccttat gtttctgttt gcgattagat tctttaaacg ctttcttctt atctttatga 162480
acagaagctt tattaaaatt atgttttgcg actaaattgt tcatagtgct gaattacctc 162540
tcttaaacat ttgcatgtga atgaaaactt tttagctaca ccacattcaa atatatgttc 162600
tcttaaatca cgtgtatcag tatatcccat ctcaacgata aaatgccgta ttagattttt 162660
atctttatca ttgagagagt taaaataatc ggattttgaa ttaatttccc tggccaaatt 162720
gaatcacctt cagttgacgt tttagttctt ttatcatctc ttcgttcatc gcaatataaa 162780
gatcgcgtaa agcaggcttt agcattccat ttattgggga actaaatgga catacataat 162840
cttttcctac gagcttttta gtgaattcca tattacagaa ctgaaatgcc ggttcattgg 162900
cataaattcc ccatttggtt gacatcattt tattggcata ttccaatgcc tggatttgat 162960
tagtaattcc atcaatttga aactttttaa tattcattag taaaggtcct cagagtaaag 163020
ttctttttca ctaccaccac gttcaatacg tacttgtcca gcgtaagttg caataatcat 163080
tgcttcttca cgtgtccaat aattactata ttggtcaata aacccttggt catcatcaca 163140
aacttgctga gtaactaatt gaggtttaac tacatctaaa actgctgcca tatctttaga 163200
ataatgacga gcacccggaa taataagagt tcgtccatct tttaatctaa aacggttggc 163260
tgcgcaaaca atccgtcgtt gatacttttg gttttcatcc cagtatgcag tctgccaaca 163320
gatttcagga acttcatcta aaacattttg ttctgtgtat tcaccactgt aagaagctaa 163380
tttagcagcc aaactttctg gagtctcgcg tgacaaagct ttatctaaca gagctaaacg 163440
ttctttaaaa gttttcattt aaaccatcct ttaatacgct gccacaaagt tttctgttga 163500
gctttgttaa caccaattga gcgaataact ggttgagatt cctggaattc tttataatca 163560
gcaaggtaaa tttcgtaagc tgaatccgta aaggaactta tagctgccat aaaattattg 163620
cgaataccta ctggagcatc tttactttca cgaataatca tgtatttgcc agtcttaatc 163680
tttacgatgg ttccaagata agctccgtgg taccagatgt cccacccctc ttgagtgggt 163740
tctgcacaac gacgaagttc attgataatt tctaacttgt tcattattta ttcctcacag 163800
ttcagatgct acagtgatta cagcttcaat gttttctact gagcgtttaa tgtcaagata 163860
cacattacca tttttagcga ttttacatga cattccgata tcagtaaatt tctgaatatg 163920
atgttccatc attttgtatc caaaaattcg catatttcca ttgttgttaa tttcaaaatt 163980
acgaattccg tgagtacgtt tttctaaaat agcgagatag ttactacgat aagtttcaac 164040
ttttttaaga acaaatccat tttcatctaa aagttttaac atgaaatctt tatcttcttc 164100
catatcagaa gtaatctcgc gagctttacg agttgctcgt tttttcagta gttccggagc 164160
attttcctgt gcgtataaag ttgctgcatt tgaaataata tcctgagctt caccagtaat 164220
gattaatcca tcaccagatt tctccaccag gcctttttta atcaataccc caatattact 164280
attaactact gcgttaccta aatctggatg cacctcacga acttctgcgg ctgtaatgaa 164340
atctttctta gcaatggtaa ttaaaatcgc agcagttttt tcattcagaa catcgttaga 164400
agctttgatg atgtaagtta ctttagacat tttctaatct ccgtaattct gtatcagtag 164460
ttgatagttg tatagtacca cagtatgctt tggttgtaaa ccgttttgtg aaaaaaattt 164520
tgaaataaaa aagggagagc cgaggctctc cctaaaattt actgcatgac tgtgataact 164580
gtcatgataa cacgttgaat tccgaacgca agaagacctc ctgctacagc tggaacaaca 164640
cctaaacccg ccagtaaaat gccaccggat actaatgcag cgcttgtaat acctatgaat 164700
ggactcattt gatttcctct aaatctttgg tgtattctgt aactacatca gtagttttcc 164760
aatattcgtt ttcttctttc ttagctttag cttcttcagc aagtttcttt gcttcgtcgg 164820
aagtcatatg aaaaatgttc attccaacta gtttatcaac ataagaagaa tacatatcaa 164880
ttttagaaag ttcttcggtc agttctttgc gagttttacc ttgtacaaca atttcacccg 164940
aaatcacttt cttaatgaaa tgtgccttgg caaaggctaa acgaaatgct gattcagttt 165000
ctttgatttt attatcaatt cgtttttgga cataagtttt acgaacttca acaaagtctt 165060
taattaaatc aactacgtta tcgtaaactt gtagctttcc tttctcgttg atgactgtaa 165120
tattttggga acgacgctca atcaacccaa agtctttcat aatttttgca tggcgttctt 165180
cttcgttatc gctcaaagag tattctttac ggaatttaac tttaaagcca aaaccgtgct 165240
caccacaagc atcatcccat gtaatgaagc ctttatcttc aagcgggtct aagattttac 165300
tcacataagt ttcacgatca tacttatacg gaatctcagt gatatgcatt tgggttcgtg 165360
aaataaactt gtacgttcca cgaatttcat attggccatc aatttcaacg acttcaccac 165420
gaaattctgg gaattctacc ttcggtttag ttactttctt tccttgaaga gcttgtagta 165480
cagctttctt gacagaagaa acactatgag gaagaatgta agttgcataa ccagttgcaa 165540
taccggaaac accattaaga agaacggtag gaataatagg caaatagaaa gcaggcggaa 165600
tgtgttcttt atcttgatgt accggagcat attcagtatc tttatataca ctatagaaat 165660
ttttacttac acgagcaaaa atataacgac tcgccgctgc tttttgaacg gtacgagaac 165720
caaagtttcc ttgaccatct aacaaaggaa agttattatt ccaagtgtta gccatcaaag 165780
cccccgcgtc ttgcgcagag ttttcaccat gatgatatcc aaggtctgct acaccacctg 165840
caatagaagc aagtttgtga aacttatctt tatttcctcg tgccaaatca agagctcgag 165900
caataacaaa tcgttggacc ggcttaaatc catcaatcat atttggaata gcacgatttt 165960
caaccgtgta catagcataa gccagtgctt cattgtcaat gatacttttt aaatcgcgat 166020
tattcagttg cataaattta ccatactagt gaatgtagtg ccataataac atcagaaatg 166080
aaaagcacga cttgaattaa tccgaacatt actccataat atagcgctac caataaagta 166140
gcaagggcta atgaatagcc caagattttc ttaatcattg gtagataaca acacaaatgt 166200
taaatatgca cacataccct gggctaaagc ttgtgaaaac acactgctag catcaataca 166260
gatagttaaa acacatgcta ctatccaaca aataaatgaa ataactccta atagtttcgc 166320
aatattcata ttttcctcac tggcgtccga agacgccttt agttttaaga ttgttacgat 166380
agaactgcat cacatgttcg ttatggaaat tactcattag tatgcctgca aaacaaattt 166440
aaagttatca gccaacatac gattcatttc ttcaagcgtt tgatactcag aatgatgatt 166500
acgagtaaac gctaaagcta actgaccttt tccaaatccc gtcgtcagag gtttcatctt 166560
agaagcaggc aaataaaata ctgtgtatgg aacattgtta tttgcaatag tacgcgcaag 166620
ctgagaccga cgctgacgaa tatgacttag aactgcgctg aatccttgct tagaacgttg 166680
attacctaca taaaatcgtg cagatacaca cggactatca aatggaccgc caaatttgct 166740
cactaaaaag taaaatccag ggttagacaa aatgtcttta tgcggagttc caaaaaccca 166800
ttcaccgccc ttgattgcac caataacagt agcgcctgca ttattcagat cagtaacagt 166860
catgtatttc atattaattt cctctaatta ttttctactc caaggccgcg tgaatacatg 166920
cggccgataa attaatcgtc gcagtcgacg ctcaattccc agaactcttc tacagtataa 166980
gtttcagtat cattttcaat acagaaacgt tcattactgt tatttgctaa agtagcgtta 167040
actgtcattt tctcgctagt gctcttaaga ggtgaaatac gaattaactg atcaccatta 167100
tctaaacaga aaatttcacc aacttttaca tctttaaaga ttttcataat tcacctcaag 167160
gagtataaaa tccaaatgca gttgttgacc atcccatcca atatgggaaa tttgcaccaa 167220
tgtaaaacat aagaatataa aaccaaatgc ttagtaaatt cattatttta caccattcca 167280
aattgtttca accacagatt tcaaaccatt ttggtgaata tccattccga caactgccat 167340
taaatagatt ccaactacaa ctgaacccaa ggcgaaaatc agcatgaaaa taaataaagc 167400
cggaaaaata ttatcgaaaa accattcaat aaatgtaaaa gcactacgtt tacgcttcat 167460
attttcctca cataaatcca aagtaagcgt ttaatacatc aatcattaaa acgattggga 167520
atatactcaa aactactaat attataacta cattccatat agctttaaca atctttttca 167580
ttttctgttc ctccgtagtt gatagggtaa taataccaca gaggaacagt cttgtaaaca 167640
acttttttaa aaatattcgt aataaatgtg aataccaact actaccgctg aaacttgtgc 167700
aacccaccac gcacaagcaa taagcacaga attcaaaatt ttcataataa cctcatcaca 167760
aaagtaaata ctaaacaaat caatggaata ctaattaacc aaacaaaaca ccaccacaat 167820
gaactcatag ttcaatctca gcgattttca tttcattact attaatagcc gctttaagac 167880
tatctgaaag aattacattc cagtggtcat tcatatgacc attaactaag cgcgtaattt 167940
cttcgggagt tgaaaaataa ggcgtatcag actcccaatg cgatagtccc aagcgagtat 168000
aaatcatacc ttcatcatcg ctagaatatt caactgacac aaactcatca gttattttat 168060
gtttagcgta ataaaattta aatttcattt tactcaataa tccgctaaaa gatcgacgat 168120
tgcatcacga agacacttat tcgcaatacg cttaagagca atttcagttt ctggagcatt 168180
ttgaataatc attgaattca attcagcctc agcaaactga agttctttaa ctaattcagc 168240
tttatatttt ccttgccctt tcttagcttt tgctcgtttt aattcagttg tagtaaacat 168300
tttattctcc aaatccgtat cagttgatag ttgtatagta ccacagtcct tgtggtatgt 168360
aaactgcttt gtgaaaattt ttaaatggaa agataccatc cgttgtagtt gctttttctt 168420
acaaccttac gaaggtcttc tctatcaccg atgaacttcg gagtgtactg gatgacacct 168480
ggatgaattt ctttagtgtt gaatataatt atacagtcag cgacttggtg attcagaatg 168540
ggccctagat ttattccaga accgtatgga tactctccgc tgcatccggt tgttaccgaa 168600
atccaacgtg agtcagtttg atgtgtctta acttctacac gaagtccgca gtatcttgga 168660
tgcgccaata catcccatgc gtatgtatac gggtcattaa catcctcttg gcctttatta 168720
acatacccgc tcagccaatc tgctacaaaa aattctgcgt acacagcgat acgacatctt 168780
tcgataactt ctgctttatc ctgatttgga ttttgtttta aagagtatct tgctgtatca 168840
gcaattttga ccttcatttc actagtcaag tcactgttcg atagggtaaa tgctggaatc 168900
tgaaatagtc tctgtaaacc cggattcgtt ttctgcatta aactttcctt ttacgtcgga 168960
atcactgatg ttaatataat aaatcatagt ttcccttaaa acaaaagggc cgaagccctt 169020
tactttattt gaattgtgca attcttttct ctaaacaatc tgcgtaagat ttcattgaaa 169080
taaactgcga aagcagtaat tcttgctcga cttcattaat cgttagaaac tttgtgcttt 169140
ctaaaaattt gctcagtgca ttaattttga gcattaattg atcgtattct tcttttactc 169200
gtgcttgata acctaacata attttcctca gtaaggggcc gaagccctta tttaaattgt 169260
tcagtaacgt cttcaactac ttcgtattgg caggtacgca ttttagcatc gttgtaatca 169320
atcggaattg atactacatc gcgaggatgt actttaactt ttacaactcg gctggttgaa 169380
ctgccaaagt gacgaatata agatttagaa cacacatgca gaccacgaga acaagtttgt 169440
gtatcatcgt cattcacacg agtacgtggc attttaacta ctttaccagg actgttatca 169500
aaggtatttg aatgacagtc aaagtaattg ctgcgaacta ctttccaagc atagaagtaa 169560
ccgtcttctg taatttcaat atcgtttgct accaagaaat caaagagtcg agataccgct 169620
ttttggctcg ggttttccaa cagattttcc aagaacggaa aataaaattc aaagttttca 169680
cctttttcca tcgaatcgag aatacgatca actaaaccag accgcaattc aatattttga 169740
taaaacaagc ttccaccttc aattcgaaca tcaccggaaa tatatttttc aacagcgcga 169800
cgaacgttaa ttttttgtgc cgcttcttcc aatttatctg caacgagcag attaagaatt 169860
tcttggaagt ttgaatgagt attaggagtt gcgttataag ttacgccgtc aacagtaatt 169920
gaaatgaatt ttttagatgc attccaaata atgtcagatt tagcaactgg agcaatagct 169980
acatcgctct taacttcaac tgtaatgtca ccgctaatgg taactttgga gcgctcagct 170040
tcttcagcat ttttcaaaac acgacggatt gtgtccaccg atacaccttg ccaatcagcc 170100
aattcctgtt gggtgtaatt accacttgaa tacagtttga caatttcagc ttgttcgttt 170160
ttggtcaggc atttaatatt gtacataatt ttcctta 170197
Claims (10)
- 병원성 대장균(pathogenic Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC10.
- 제1항에 있어서, 상기 박테리오파지는 기탁번호 KFCC11669P인, 박테리오파지 EC10.
- 제1항에 있어서, 상기 병원성 대장균은 장출혈성 대장균(Enterohaemorrhagic E. coli, EHEC), 장독소성 대장균(Enterotoxigenic E. coli, ETEC), 장침입성 대장균(Enteroinvasive E. coli, EIEC), 장응집성 대장균(Enteroaggregative E. coli, EAEC), 장병원성 대장균(Enteropathogenic E. coli, EPEC), 및 시가독소 생산 대장균 (Shigatoxin producing E. coli, STEC)으로 구성된 군으로부터 선택된 1종 이상인, 박테리오파지 EC10.
- 제1항의 박테리오파지 EC10을 포함하는, 항생용 조성물.
- 제1항의 박테리오파지 EC10을 포함하는, 사료 첨가용 조성물.
- 제5항의 사료 첨가용 조성물을 포함하는, 사료.
- 제1항의 박테리오파지 EC10을 포함하는, 소독제.
- 제1항의 박테리오파지 EC10을 포함하는, 세척제.
- 제1항의 박테리오파지 EC10을 인간을 제외한 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법.
- 제9항에 있어서,
상기 개체는 돼지, 소, 닭, 말, 오리 및 개로 이루어진 군에서 선택된 1 종 이상인, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료방법.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220120307A (ko) * | 2021-02-23 | 2022-08-30 | 씨제이제일제당 (주) | 장독소성 대장균에 대한 특이적인 사멸능을 가지는 신규한 박테리오파지 및 이를 포함하는 항균 조성물 |
GB2605465A (en) * | 2021-03-29 | 2022-10-05 | Jiangsu Acad Agricultural Sci | Bacteriophage composition, bacteriostat, and use thereof |
-
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Non-Patent Citations (4)
Title |
---|
Escherichia phage vB_EcoM-UFV13, complete genome. 2016.04.27., GenBank: KU867876.1.* * |
Genome Announcements. 2016.12.08., Volume 4 Issue 6, e01292-16, pp. 1-2.* * |
JOURNAL OF BACTERIOLOGY. 2003, vol. 185, pp. 3596-3605. * |
Veterinary Microbiology. 2003, vol. 94, pp. 47-56. * |
Cited By (3)
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---|---|---|---|---|
KR20220120307A (ko) * | 2021-02-23 | 2022-08-30 | 씨제이제일제당 (주) | 장독소성 대장균에 대한 특이적인 사멸능을 가지는 신규한 박테리오파지 및 이를 포함하는 항균 조성물 |
WO2022181891A1 (ko) * | 2021-02-23 | 2022-09-01 | 씨제이제일제당(주) | 장독소성 대장균에 대한 특이적인 사멸능을 가지는 신규한 박테리오파지 및 이를 포함하는 항균 조성물 |
GB2605465A (en) * | 2021-03-29 | 2022-10-05 | Jiangsu Acad Agricultural Sci | Bacteriophage composition, bacteriostat, and use thereof |
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