KR101993125B1 - 신규한 esbl 생성 대장균 특이 박테리오파지 eco4 및 이를 포함하는 항균 조성물 - Google Patents
신규한 esbl 생성 대장균 특이 박테리오파지 eco4 및 이를 포함하는 항균 조성물 Download PDFInfo
- Publication number
- KR101993125B1 KR101993125B1 KR1020170169340A KR20170169340A KR101993125B1 KR 101993125 B1 KR101993125 B1 KR 101993125B1 KR 1020170169340 A KR1020170169340 A KR 1020170169340A KR 20170169340 A KR20170169340 A KR 20170169340A KR 101993125 B1 KR101993125 B1 KR 101993125B1
- Authority
- KR
- South Korea
- Prior art keywords
- bacteriophage
- eco4
- esbl
- coli
- present
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3571—Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/381—Microorganisms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00031—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Mycology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Abstract
본 발명은 대장균, 특히 ESBL 생성 대장균에 특이적인 사멸능을 갖는 신규 박테리오파지 ECO4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 ECO4를 이용한 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 병원성 대장균에 대한 특이성이 매우 높고, 상기 박테리오파지 ECO4는 ESBL 생성 대장균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 ECO4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 ECO4는 대장균, 특히 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
Description
본 발명은 대장균, 특히 ESBL(Extended Spectrum β-lactamase) 생성 대장균(Escherichia coli)에 특이적인 사멸능을 갖는 신규 박테리오파지 ECO4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
일반적으로 대장균(Escherichia coli , E. coli)은 장내세균과(Enterobacteriaceae)의 Escherichia 속에 속하는 그람음성의 단간균으로 포유동물을 비롯한 다양한 동물의 장관 내에 존재하는 정상세균 총 중의 하나이다. 대장균은 일반적으로 대장에 정상적으로 존재하는 비병원성 대장균과 특정 병원성 인자(부착인자 및 내열성 독소 등)를 획득하여 병증을 유발하는 병원성 대장균으로 구분할 수 있다. 대장균은 온혈 동물의 장내에 많은 부분을 차지하고 있는 미생물이나, 대부분 비병원성 세균으로 기회감염을 유발할 수 있다. 비병원성 대장균 외의 대장균은 사람에 있어서는 설사증, 요로감염증, 패혈증 및 뇌막염 등의 질환을 유발할 수 있는 병원성 미생물이다. 가축에서는 주로 설사병 등 장관감염을 일으키며 가금에 있어서는 급성 패혈증, 만성 호흡기병 등 장관 외 감염을 일으켜 폐사를 유발할 수 있다.
대장균은 다양한 환경에서 많은 분포로 존재하는 만큼 세균을 제어하기 위해 사용되는 항생제, 약제, 항미생물제 등에 노출되어 있다. 이에 따라 다양한 항생제에 내성을 나타내는 내성세균이 출현하고 있다. 특히 항생제 중 베타-락탐(ß-lactam) 제제는 감염증 치료에 흔히 사용되는 항생제로, 병원에서 치료제로서 3세대 세팔로스포린 항균제들을 집중적으로 사용하게 되면서 이에 대한 내성균주들이 출현하게 되었고, 다양한 베타-락탐 계열의 항생제에 내성을 나타내는 세균을 ESBL(extended-spectrum ß-lactamase) 생성 세균이라고 하는데, 현재 임상에서 빈번하게 분리되고 있다. ESBL 생성 균주는 주로 장내세균과(Enterobacteriaceae)의 세균에서 생성되며 세포탁심(cefotaxime), 세프타지딤(ceftazidime), 아즈트레오남(aztreonam)과 같은 소위 제 3세대 항균제들에 대해서 내성을 가지고 있다.
1980년대 초 유럽에서 Klebsiella와 Escherichia coli를 비롯한 여러 종류의 장내세균에서 플라스미드 매개성 ESBL 생성 균주가 출현한 이후 우리나라를 포함한 전 세계적으로 임상 가검물로부터 빈번하게 분리됨으로써 질병치료에 중요한 문제로 대두되고 있다. 제 3세대 약제 내성을 획득한 균주가 분변이나 생활하수, 축산 폐기물들을 통하여 자연계로 확산될 경우, 자연계내의 여러 종류의 균에 내성을 전달할 수 있는 위험성을 가지고 있다. 또한 질병과 관련된 균에 ESBL 유전자를 전달할 경우 항균제 선택이 제한될 수 있어 질병 치료에 심각한 상황을 초래할 수 있다. 항생제는 가축에서 세균성 질병의 치료뿐만 아니라 질병 예방 및 성장 촉진의 목적으로 오랫동안 사용되어 왔다. 항생제 오남용으로 여러 가지 항생제에 내성을 나타내는 다제 내성균과 지금까지 개발된 항생제로는 치료가 되지 않는 슈퍼박테리아가 출현함에 따라 축산 분야에서 가축의 질병 치료에 어려움이 많은 실정이다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 자연 친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
그러나, 중요한 문제가 되고 있는 베타락탐계 항생제에 내성을 나타내는 세균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 베타락탐계 항생제에 내성을 나타내는 ESBL 생성 균주에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
이에 본 발명자들은 ESBL 생성 대장균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 야생형 대장균 뿐만 아니라 항생제 내성 균주인 ESBL 생성 대장균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
따라서 본 발명의 목적은 대장균(Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 ECO4를 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지 ECO4를 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 ECO4를 개체에 투여하는 단계를 포함하는, 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 대장균(Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 ECO4를 제공한다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는, 사료를 제공한다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 ECO4를 개체에 투여하는 단계를 포함하는, 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 ECO4를 이용한 대장균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 대장균, 특히 ESBL 생성 대장균에 대한 특이성이 매우 높고, 상기 박테리오파지 ECO4는 ESBL 생성 대장균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 ECO4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 ECO4는 대장균, 특히 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 박테리오파지 ECO4의 ESBL 생성 대장균에 대한 반점 분석법 수행 결과를 나타낸 도이다.
도 2는 박테리오파지 ECO4의 ESBL 생성 대장균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 ECO4의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 ECO4의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도다.
도 5는 박테리오파지 ECO4의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 ECO4의 열 안정성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 ECO4의 ESBL 생성 대장균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 ECO4의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 ECO4의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도다.
도 5는 박테리오파지 ECO4의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 ECO4의 열 안정성을 확인한 결과를 나타낸 도이다.
이하 본 발명을 상세히 설명한다.
본 발명은 대장균(Escherichia coli) 에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 ECO4를 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명에서 상기 대장균은 ESBL(Extended Spectrum β-lactamase) 생성 대장균(Escherichia coli)을 포함한다.
상기 ESBL 생성 대장균은 광범위 베타락탐 분해 효소(Extended Spectrum β-lactamase, ESBL)를 생성하는 대장균을 지칭한다. ESBL은 3세대 세팔로스포린(cephalosporin)을 가수분해하는 베타 락타마아제를 포함하는 넓은 개념이다.
본 발명의 ESBL 생성 대장균은 ESBL을 생성함으로써 베타락탐계 항생제에 내성을 갖는 것을 특징으로 한다. 베타락탐계 항생제(β-lactam antibiotics)는 페니실린, 세팔로스포린, 모노박탐, 카바페넴, 베타-락탐 분해효소 저해제를 총칭하는 단어로, 모두 베타락탐 핵을 분자 구조 내에 포함하고 있다. 베타락탐계 항생제는 예컨대 메티실린(메탐피실린), 디클록사신, 옥사실린, 플루클록사신, 아목시실린, 암피실린, 피페라실린, 티카실린, 아즐로실린, 카르베니실린과 같은 페니실린계, 세팔렉신, 세팔로틴, 세파졸린, 세프테졸, 세파제돈, 세파클러, 세푸록심, 세파맨돌, 세포테탄, 세폭시틴, 세프트리악손, 세프탁심, 세프타지딤, 세파핌, 세프피롬과 같은 세팔로스포린계, 이미페넴, 메로페넴, 에르타페넴, 파로페넴과 같은 카바페넴계, 아즈트레오남과 같은 모노박탐계 항생제를 포함하나 이에 제한되는 것은 아니다.
본 발명의 박테리오파지 ECO4는 180-200 nm의 크기로, 정이십면체의 머리를 가지며 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속하며, 단백질 패턴 분석 결과 100 kDa, 70 kDa, 50 kDa, 19 kDa 그리고 16 kDa 크기의 단백질을 포함하고 있음을 확인하였다. 또한 상기 박테리오파지 ECO4는 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.
본 발명의 박테리오파지 ECO4는 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 ECO4는 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 ESBL 생성 대장균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 ECO4를 ESBL 생성 대장균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 ECO4를 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 ECO4는 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자들은 이를 박테리오파지 ECO4로 명명하고 2016년 7월 22일에 한국미생물보존센터에 기탁번호 KFCC11675P로 기탁하였다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명의 박테리오파지 ECO4는 대장균, 특히 ESBL 생성 대장균에 특이적인 사멸능을 가지므로, 다양한 종류의 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다.
본 발명에서, 대장균에 의한 감염성 질병은 예컨대 유행성, 급성 또는 만성으로 발병하는 전염성 질환을 통칭하는 대장균증을 의미한다. 본 발명의 용어 대장균증이란, 가축에 병원성 대장균이 감염되어 발생하는 질병을 의미하는데, 증상으로는 패혈증, 설사(신생기 설사 및 이유 후 설사), 독혈증(부종병 및 뇌척수혈관증) 등이 있으나, 이에 제한되는 것은 아니다. 병원성 대장균은 가축의 장간막, 위, 앞머리와 눈꺼풀의 피하조직, 후두, 또는 뇌를 통하여 감염될 수 있다. 본 발명에서 병원성 대장균에 의한 감염성 질병은 설사 또는 부종병에 의해 발생하는 출혈, 부종, 혈관내피의 손상, 혈관 내 응고, 미세혈전 등의 증상을 제한 없이 포함한다.
본 발명의 박테리오파지 ECO4는 ESBL 생성 대장균에 대해 특이적인 사멸능을 가지므로, 이를 포함하는 조성물은 흔히 사용하는 항생제인 베타락탐계 항생제에 내성을 보이는 대장균에 의해 발생하는 질병을 예방 또는 치료하기 위해 사용될 수 있다.
본 발명의 약학적 조성물은 1×103 내지 1×1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1×106 내지 1×109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU(plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.
본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화 되는 조성물에 있어서 허용되는 약학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 ECO4를 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화 하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 ECO4는 기존 항생제에 비하여 대장균, 특히 ESBL 생성 대장균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 사료 첨가용 조성물을 제공한다.
양돈, 축산, 수산업, 반려동물 산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 동물에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 ECO4를 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조 상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 동물의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 ECO4를 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 ECO4를 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 ECO4 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 ESBL 생성 대장균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 박테리오파지 ECO4를 포함하는, 소독제를 제공한다.
대장균, 특히 ESBL 생성 대장균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 ECO4를 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 ECO4를 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 ECO4는 대장균에 특이적 사멸능을 가지므로, 상기 대장균에 노출되었거나 노출될 가능성이 있는 동물의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 ECO4를 개체에 투여하는 단계를 포함하는, 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 방법은 대장균에 의한 감염성 질병, 예컨대 가축에 병원성 대장균이 감염되어 발생하는 질병을 의미하는데, 증상으로는 패혈증, 설사(신생기 설사 및 이유 후 설사), 독혈증(부종병 및 뇌척수혈관증) 등이 발생한 개체 또는 ESBL 생성 대장균의 감염에 의해 베타락탐계 항생제에 내성을 보이는 질병이 발생한 개체에 박테리오파지 ECO4를 투여하는 단계를 포함한다.
본 발명에서, 용어 "개체"는 인간을 포함한 동물, 바람직하게는 인간, 가축류 또는 반려동물을 말하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 인간과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 조류, 어류, 곤충류, 포유류를 모두 포함하는 개념이며, 상기 가축류는 돼지, 소, 닭, 말, 오리 및 개로 구성된 군에서 선택될 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 ECO4 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 개체의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 ECO4 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 ECO4의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예
1:
신규한
박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리
ESBL(Extended Spectrum β-lactamase)을 생산하는 대장균(이하 ESBL 생성 대장균으로 지칭함)에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하였으며, 박테리오파지 분리에 사용된 대장균인 ESBL 생성 대장균은 (주)옵티팜이 아시아태평양 감염연구소에서 분양받은 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 ESBL 생성 대장균과 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 시료 여과액에 대해 ESBL 생성 대장균이 접종되어 있는 LB 플레이트에 전처리한 시료를 점적하여 15시간 동안 배양하여 스크리닝하는 반점 분석법(spot test)을 수행하고 그 결과를 도 1에 나타내었다.
도 1에 나타낸 바와 같이, ESBL 생성 대장균에 대해 용균 활성이 나타나는 시료를 확인하였으며, 용균 활성이 확인된 시료에는 ESBL 생성 대장균을 용균할 수 있는 박테리오파지가 존재하는 것으로 추정하고 용균반 형성을 확인하였다.
용균반 형성을 확인하기 위하여, 전배양된 ESBL 생성 대장균 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 LB 탑 아가(top agar) [LB 배지(트립톤 10 g/L, 효모 추출물(yeast extract) 5 g/L, NaCl 10 g/L) + 0.6% 아가]를 첨가하여 잘 혼합한 후 미리 만들어둔 2% LB 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(ESBL 생성 대장균) 배양액 150 μL에 혼합한 후 0.6% LB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% LB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% LB 탑 아가가 포함된 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 LB 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, LB 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 ESBL 생성 대장균 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예 1.1에서 확인한 ESBL 생성 대장균 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x107 PFU/mL로 희석한 후 전배양된 ESBL 생성 대장균 1.0x1010 CFU/mL과 혼합하여 MOI (Multiplicity of infection)를 0.001이 되도록 하여 35℃에서 120 rpm으로 9시간 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 ECO4(Bacteriophage ECO4)"로 명명하고, 2016년 07월 22일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 기탁번호 KFCC11675P를 부여받았다.
실시예
2: 박테리오파지
ECO4의
전체 유전자 분석
박테리오파지 ECO4의 전체 유전자를 분석하기 위해, 박테리오파지 ECO4 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액(Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국).
박테리오파지 ECO4의 전체 유전자 서열 분석 결과, 박테리오파지 ECO4의 전체 유전자의 크기는 168,638 bp 이며, GC함량이 36%, 전체 ORFs의 수는 272개임을 확인하였다. 분석한 박테리오파지 ECO4의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예
3: 박테리오파지
ECO4의
형태학적 특성
박테리오파지 ECO4의 형태학적 특성을 알아보기 위해, 박테리오파지 ECO4를 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 카본 코팅된 운모판(carbon-coated mica plate, ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균 증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경(Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 검경하였으며 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 ECO4은 180-200 nm의 크기로, 정이십면체의 머리를 가지며 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.
실시예
4: 박테리오파지
ECO4의
단백질 패턴 분석
박테리오파지 ECO4의 단백질 패턴을 분석하기 위해, 1.0x1010 PFU/mL로 준비된 박테리오파지 ECO4 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 ECO4은 100 kDa, 70 kDa, 50 kDa, 19 kDa 및 16 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예
5: 박테리오파지
ECO4의
다양한 세균에 대한 감염성 조사
박테리오파지 ECO4의 다양한 세균에 대한 감염성을 조사하였다.
우선, 박테리오파지 ECO4가 아시아태평양 감염연구소에서 분양 받은 ESBL 생성 대장균에 대하여 감수성을 나타내는지 여부를 소프트 아가 오버레이법을 통해 확인한 결과를 표 1에 나타내었다.
상기 표 1에 나타낸 바와 같이, 박테리오파지 ECO4는 14균주의 ESBL 생성 대장균에 대한 용균활성을 확인한 결과, 12 균주에 대해 감수성이 있는 것으로 나타났으므로 ESBL 생성 대장균에 대한 용균활성이 탁월함을 확인하였다.
또한, 박테리오파지 ECO4가 다양한 세균에 대하여 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.
상기 표 2에 나타낸 바와 같이, ESBL 생성 대장균 외에도 다른 미생물을 대상으로 감수성 검사를 진행한 결과, 박테리오파지 ECO4는 병원성 대장균에 대해 용균활성을 나타내는 것을 확인하였다. 그러나, Salmonella Typhimurium, Bacillus cereus, Listeria monocytogenes, Lactobacillus plantarum 등에는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 ECO4는 대장균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예
6: 박테리오파지
ECO4의
pH 안정성 조사
박테리오파지 ECO4의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 uL로 분주하여 준비하였다. 8.0x109 PFU/mL로 준비한 박테리오파지 ECO4 배양액 10 μL을 상기 용액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, pH4-10의 범위에서는 초기 박테리오파지 투입수에 비해 감소량이 크지 않아 박테리오파지 ECO4는 2시간 동안 안정한 것으로 확인되었다. pH2의 경우에는 박테리오파지의 수가 약 4 log, pH3에서는 약 1 log, pH11에서는 2 log가 감소됨을 확인하였다.
따라서, 본 발명의 박테리오파지 ECO4는 pH4-10의 범위에서 안정함을 확인하였으므로, 박테리오파지 ECO4는 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
실시예
7: 박테리오파지
ECO4의
열 안정성 조사
박테리오파지 ECO4의 열 안정성을 확인하기 위하여, 다양한 온도 범위 (40℃, 50℃, 60℃, 70℃)에서 박테리오파지의 수를 측정하였다. 박테리오파지 ECO4 배양액 (8.0x107 PFU/mL) 5 mL을 멸균된 튜브에 분주한 후 박테리오파지를 첨가하여 10분, 30분, 60분 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.
도 6에 나타낸 바와 같이, 40-60℃의 범위에서 안정함을 확인하였다.
상기 실험으로부터 박테리오파지 ECO4는 ESBL 생성 대장균에 대한 특이성이 매우 높고, ESBL 생성 대장균에 감염하여 ESBL 생성 대장균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 ECO4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 ECO4는 대장균, 특히 ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 ECO4를 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예
1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 ECO4 1×106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으로 제조한다.
1.2
액제의
제조
박테리오파지 ECO4 1×106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 ECO4 1×106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
SEQUENCE LISTING
<110> Optipharm.CO.,LTD
<120> Novel ESBL producing Escherichia coli specific bacteriophage ECO4
and antibacterial composition comprising the same
<130> 1-26P-1
<150> 10-2016-0176714
<151> 2016-12-22
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 168638
<212> DNA
<213> Bacteriophage ECO4
<400> 1
acaaggaaaa gctgtttggt ctttaggtac tgaaattaat tccgggactt ttgttttgca 60
tcattacaaa gaagacggga cccaaggtca tacatcaaga tttaatgctg atggtacagt 120
caatttcccg gataacgtac aggtcggtgg tggtgaagct actattgccc gaaatggtaa 180
tatcttctct gatatttgga aaacatttac ttcggcaggc gatataacta acattcgtga 240
tgcgatagct acccgtgttt ctaaagaagg cgacacgatg acaggccgct taactcttaa 300
aaccaactcg gatgctgttg ttattgatta tccagcagat gaagcgggct atgttaaggg 360
taaaaaaggt ggcgctgata actggtatgt cggtaatggt ggtgctgata atggacttgc 420
cttctggagt ttccaatccc aaggcggtat taatatcaac ccgaacggtg aagttattct 480
atctccacag ggcactagta tattcaatat aaaccgtgac cgaattcata tgaacggtgc 540
tcactgggtt gcgcgtaaat ctggtgcgtg gggcgaccaa tggggcttag aagcacctta 600
tttccttgat tttggtagcg ttggcgaaga tagttattat cctattatta aaggccgttc 660
tgtaattact ggtcaaggat atactacttc tgttgacctt ggtattagac gtacaccaca 720
agcctgggga caagcgataa ttcgagtagg taatgccgag cgtggcgacg ggcctgtggg 780
tgttttcgaa ttccactcta gcggtttatt ttacgccccg tctttagtcc agactcctgc 840
cattggtgtt ggtactgtta acggattagg ctctcctagt attgctatcg gtgataatga 900
cacaggatta tcacacggcg gtgatggccg aatcaatatg gttgccgatg gtatgcatat 960
tgcatcttgg tctggctctt accatatcca tgaaggtctt tgggatacca ctggtgcctt 1020
gtggactgaa acaggaagag ctattatttc ttttggtcat ttagtccaac aacacgatgg 1080
ctattcaaca tttgttcgtg acgtttatgt tcgttctgat attcgtgtta aaaaagacct 1140
tgttaaattt gaaaatgctt cacaaacact ttcaaaaatt aacggttaca cttatatgca 1200
gaaacgtggc ctggatgaag aaggtaatca gaaatgggaa cctaatgctg gtttaattgc 1260
tcaagaagtt caagctattt tgcctgaatt agttgaaggt gaccctgatg gcgaagcttt 1320
acttcgtttg aactataacg gtgtaattgg tttaaataca gctgcaatca atgagcatac 1380
tgcagaaatt gcagaactta aatcagaaat cgaagaactt aaagcattag ttaaatcatt 1440
gttaaaataa taagaggggc ttcggcccct tggaggttta tatggcagta gcaggaccgt 1500
ggataggaat ttctgcattg gcacagactg gagaccattg gatggcagga gcagccgcaa 1560
gattaagatt gggtgttcct tgctggatga gtcaatttgc aggtcgctca cgagaaatta 1620
ttcacacgct tggagcagac cataacttca atggtcaatg gttccgagat agatgttttg 1680
aggcaggtag tgcacctata gtgtttaata ttacaggtga tttagtatca tattctaaag 1740
atgttccttt attcttcatg tacggagata caccaaatga atatgttcag ttaaatatac 1800
atggcgtaac gatgtatgga cgtggcggta atggtggtag caatagtcct ggctcagctg 1860
gaggtcattg tattcaaaac gatattggtg ggagactaag aattaataat ggtggagcta 1920
ttgctggcgg tggcggtggc ggtggcggcg gatattattc tcctttttca caaatgagat 1980
taacctttgg cggtggtggt gggcgtccgt ttggtgcacc tggcggatct attgatatgc 2040
aatcaggcgc aactgctggt actatttctg cacctggctc aggatccgtg aatggtatct 2100
ataatggtgg aaacggtggt gaagtaggtt ccgcgggagg tagatgcaat attcgcggtc 2160
aaggatctga atataatggc ggcgctgcgg gttatgctgt catagggtct gctccaacgt 2220
ggcaaaatgt tggagcaata tatggtccaa gagtataatg tgaataaata cccttaaaag 2280
gagggtctat gacagcacct agaatatcat tttcgccctc tgatattctg tttggtgttc 2340
tagatcgctt gttcaaagat aacgctaccg ggaaggttct tgcttcccga gtagctgtcg 2400
taattctttt atttatgatg gcgattgttt ggtatagggg agatagtttc tttgagtact 2460
ataagcaatc aaagtatgaa acatacagtg aaattattga aaaggaaaga aatgcacgct 2520
ttgaatctgt cgccctggaa caactccaga tagttcatat atcatctgag gcagacttta 2580
gtgcggtgta ttctttccgc cctaaaaact taaactattt tgttgatatt atagcatatg 2640
aaggaaaatt accttcaaca ataagtgaaa aatcacttgg aggatatcct gttgataaaa 2700
ctatggatga atatacagtt catttaaatg gacgtcatta ttattccgac tcaaaatttg 2760
cttttttacc aactaaaaag cctactcccg aaataaacta catgtacagt tgtccatatt 2820
ttaatttgga taatatctat gctggaacga taaccatgta ctggtataga aatgatcata 2880
taagtaatga ccgccttgaa tcaatatgtg ctcaggcggc cagaatatta ggaagggcta 2940
aataattatt tgttcgtata catttctaga tatcgatata caccctcaaa accctcgttg 3000
aattcatcga tgagggtttt cttatcttct tgagttaatt cagaaacaat tttacgaaat 3060
gaattctgat ttaactttct accttcatgc gttactccaa tctcattaag aaatgcaata 3120
aaattagcac gattctcaac aatatcttct ctggaaaatt taatcaaaat agatgcaaca 3180
gtaataattt cacgaactgt atcaatgttt ttattcatta actataccac tcaattagtt 3240
gactttgtta taatatcatc agacgcttga tttgtaaact ggtctgtgtt attttcttca 3300
aaaatttttt ctacgaattc cttgaacgac tcgcgttcct gagctacatt atgctcgatt 3360
accttttcaa gattatgact cattcgaaat aatcttcaat ttcgtaatca tggacataaa 3420
tcattatagt ttttaataca tcatcaatac tttttcctgg agctggaatt acgtaaaaat 3480
atcctgcttt tgagaggtct ttataagttc caatcaagaa atcattattc tcaagatgta 3540
actcttcaac taattcattg acaattgaat ggtataggtt tggtagaaac ttatatagct 3600
tttctagaat atcaattttg attgtgtatt gaaccacgga ctgagaatca ataatcatag 3660
accttcccct tatgtttctg tttgcgatta gattctttaa acgctttctt cttatcctta 3720
tggacagaag ctttattaaa attgtgtttt gcgactaaat tgttcatagt gctgaattac 3780
ctctctcaaa cacttgcatg tgaatgaaaa ctttttagct acaccacatt caaatatatg 3840
ttctcttaaa tcacgtgtgt cagtatatcc catctcaaca ataaaatgtc ttattagatt 3900
tttatcttta tcattgagag aattaaaata atcggatttt gaattaattt ccctggccaa 3960
attgaatcac cttcagttga cgttttagtt cttttatcat ttcttcgttc atcgcaatat 4020
aaagatcgcg taaagcaggt tttagcattc catttaccgg agaactaaat gggcatacat 4080
aatcttttcc tacaagcttt ttggtaaatt ccatatcaca aaatttaaat gctggctcat 4140
tcgcataaat tccccaatta gttgacatca ttttattggc atattccagt gcctgaattt 4200
gattcataat tccatcgatt tgaaactttt taatattcat tagtaaaggt cctcagagta 4260
aagttctttt tcactaccac cacgttcaat acgtacttgt ccagcgtaag ttgcaataat 4320
cattgcttct tcacgtgtcc aataattact gtattggtca ataaaccctt ggtcatcatc 4380
acaaacttgt tgagtaacta attgaggttt aactacatct aaaacttcgg ccatatcttt 4440
agaataatga cgagcacctg gaataataag agttcgtcca tcttttaatt taaaacggtt 4500
ggctgcacag acaattcgtc gttgatactt ttgattttca tcccaatacg cagtctgcca 4560
acaaatttca ggaacttctt tcagaatatc ttcttctgtg catttataac catgcgcttt 4620
aaatttttca gcaagacttt ctggagtttc acgagataaa ggaacattca gcatttttaa 4680
acgattgata aatgggttca tttaaaccat cctttaatac gttgccacaa agttttctgt 4740
tgagctttgt taacaccaat tgagcgaata actggttgag attcctggaa ttctttataa 4800
tcggcaaggt aaatttcgta agctgcatct gtaaaggaac ttatcgctgc catgaaatta 4860
ttgcgaatac ctactggagc atctttactt tcacgaataa tcatgtattt accagtctta 4920
atctttacaa tagttccaag ataagctcca tggtaccaaa tatcccaacc ctcttgagta 4980
ggttctgcac aacgacgaag ttcattgata atttctaact tgttcattat ttattcctca 5040
cagttcagat gctacaatga ttactgcttc aatgttttct tccgagcgtt taatgtcaag 5100
atacacatta ccgtttttag cgattttaca tgacattccg atatcagtaa atttctgaat 5160
atgatgttcc atcattttgt atccaaaaat tcgcatattt ccattgttgt taatttcaaa 5220
attacgaatt ccgtgagtgc gtttttctaa aatagcgaga tagttactac gataagtttc 5280
gaccttttta agaacaaatc cattttcatc taaaagtttt aacatgaggt ctttatcttc 5340
ttccatatca gaagtaatct cacgagcttt acgagttgct cgttttttca gtagttccgg 5400
agcattttcc tgtgcgtata aagttgctgc atttgaaata atatcctgag cttcaccagt 5460
aatgattaat ccatcacctg atttctccac caggcctttt ttaatcaaca ccccaatatt 5520
actattaact actgcgttac ctaaatctgg atgcacctca cgaacttcta cagctgtaat 5580
gaaatctttc ttagcaatag taattaaaat cgcagcagtt ttttcattca gaacatcgtt 5640
agaagctttg atgatgtaag ttactttaga cattttctaa tctccgtaat tctgtatcag 5700
tagttgatag ttgtatagta ccacagtatg ctttggttgt aaaccgtttt gtgaaaaaat 5760
ttttgaaata aaaaagggag agcctcggct ctccctaaaa ttactgcatg actgtgataa 5820
ctgtcatgat aacacgttga attccgaacg caagaagacc tcctgctacg gcaggaacaa 5880
cacctaaacc cgccagtaaa atgctaccag atactaatgc cgcgcttgta ataccaatga 5940
atggactcat ttgatttcct ctaaatcttt ggtgtattct gtaactacat cagtagtttt 6000
ccaatattcg ttttcttctt ttttggcttt agcttcttca gcaagtttct ttgcttcgtc 6060
ggaagtcata tgaaaaatgt tcattccaac tagtttatca acataagaag aatacatatc 6120
aattttagaa agttcttcgg tcagttcttt gcgagtttta ccttgtacaa caatttcacc 6180
tgaaattact ttcttaatga aatgtgcctt ggcaaaagct aaacgaaatg ctgattcagt 6240
ttctttgatt ttgttatcaa ttcgtttttg gacataagtt ttacgaactt caacgaagtc 6300
tttgattaaa tcaactacat tatcgtaaac ttgcagcttt cctttctcat taatgacggt 6360
aatattctgg gaacgacgct caatcaaccc gaagtctttc ataatttttg catggcgttc 6420
ttcttcatta tcgctcaaag agtattcttt tcggaattta actttgaagc caaagccatg 6480
ctcaccacaa gcatcatccc atgtaatgaa gcctttatct tcaagcgggt ctaagatttt 6540
actcacataa gtttcacgat catacttata tggaatctca gtgatatgca tttgagttcg 6600
tgaagtaaac ttatatgttc cacgaatttc atattgccca tcaatttcaa cgacttcacc 6660
acgaaattct gggaattcta ccttcggttt agttactttc tttccttgaa gagcttgcag 6720
tacagctttc ttgacagaag aaacactatg aggaagaatg taagttgcat aaccagttgc 6780
aataccggaa acgccattaa gaagaacagt aggaataata ggcaaataga aagcaggcgg 6840
aatgtgttct ttatcttgat gtactggagc atattcagta tctttatata cgttatagaa 6900
atttttactt acacgagcaa aaatataacg acttgctgct gccttttgga cagtacgaga 6960
accaaagttt ccttgaccgt ctaacagagg aaagttatta ttccaagtgt tagccatcaa 7020
agcacctgtg tcttgcgcag agttttcacc atgatgatat ccaaggtccg ctacaccgcc 7080
tgcgatagaa gcgagtttgt gaaacttatc tttatttcct cgtgccaaat caagagctcg 7140
agcaataaca aatcgttgaa ctggcttaaa tccgtcaatc atatttggaa tggcacgatt 7200
ttcaaccgtg tacatagcat aagccaatgc ttcattatca atgatacttt ttaaatcacg 7260
attattcagt tgcataaatt taccatacta gtgaatgtag tgccataata acatcagaaa 7320
tgaaaagcac gacttgaatt aatccgaaca ttattccgta atataatgct atcaataaaa 7380
tagcaagggc taatgaatag cccaagattt tcttaatcat tagtagataa caacacaaat 7440
gttaaatatg cacacatacc ctgagctaaa gcttgcgaaa acacactgct ggcatcaata 7500
cagatagtta aaacacatgc tactatccaa caaataaatg aaataactcc taataatttt 7560
gcgatattca tattttcctc actggcgtcc gaagacgcct ttagttttaa gattattacg 7620
atagaactgc atcacgtgtt cgttgtggaa attactcatt aatacgcctg caaaacgaat 7680
ttaaaattat cagccaacat acggttcatt tcttcaagtg tttgatactc agaatgatga 7740
ttacgagtaa acgctaaagc taactgtcct tttccaaatc ccgtcgtcag aggtttcatc 7800
ttagaagcag gcagataaaa tattgtgtat accatattgt tatttgcaat agtacgtgca 7860
agctgagacc gacgttgacg aatatgactt agaactgcac tgaatccttg cttagaacgc 7920
tgattaccta cataaaatcg tgcagacaca catggattac taaatggacg accatctaat 7980
ttacttacta aaaaataaaa tccaggttta gataaaatat ctttatgcgg agttcccaaa 8040
aaccactcac cacccttgat tgtaccaata acagtagcgc ctgcattatt cagatcagta 8100
acagtcatgt atttcatatt aatttcctct aaattatttt ctactccaag gccgcatgaa 8160
tacacgcggc cattaaatta atcgtcgcag tcgacgctca attcccaaaa ctcttctacg 8220
gtataagttt cagtatcatt ttcaatacag aaacgttcat tactgttatt tgctaaagta 8280
gcattaactg tcattttttc gctagtgctc ttaagaggtg aaatacgaat taactgatca 8340
ccgttatcta aacaaaaaat ttcaccaact tttacatctt taaaactttt cataattcac 8400
ctcaaggagt ataaaatcca aacgcagttg ttgaccatcc catccaatat ggaaaatttg 8460
caccaatgca atgtaaaaca taagaatata aaaccaaccg ctcagcaaat tcatcatttt 8520
acaccattcc aaattgtttc aaccacagat tttaagccat tttgatgaat gtccattccg 8580
actaccgcca tcaaatagat tccaactaca actgaaccta aggcaaaaat cagcatgaaa 8640
atgaataaag ccggaaaaat attatcgaaa aaccattcaa taaatgtaaa agcactgcgt 8700
ttacgcttca tattttcctc acataaatcc aaagtaagcg tttaatacat caatcattaa 8760
aacgattagg aatatactca aaactactag tattataact acattccata tagctttaac 8820
aatctttttc attttctgtt cctccgtagt tgatagggta atagtaccac agaggaacag 8880
tcttgtaaac aactttttta aaaatattcg taataaatgt gaataccaac tactaccgct 8940
gaaacctgtg caacccacca cgcacaagca ataagtacag aattcaaaat tttcataata 9000
acctcatcac aaaagtaaat gttaaacaaa ttactggaat actaattaac caaacaaaac 9060
accaccataa tgaactcata gttcaatctc agcgatttcc aagtgttttt gttttattgc 9120
ctttttaaca caatcatgga ctaaatatga ccatgaatca ttatattctc cattaactaa 9180
tcgttggaga tcttcgcgtg atgataagta aggttgatct gattcccatt ttgataaaaa 9240
tactgcagta aaaatatctc cttcacctgt agttgaagtc gtaaatgcaa taaattcacc 9300
ggtaatttta tgtttagcgt aataaaattt aaatttcatt tttactcctc cgtagctgat 9360
agttgtatag taccacggtc cttgtggcat gtaaaccatt ttgtgaaatt ttttaaatgg 9420
aaagatacca tccgttgtag ttgctttttc ttacaacctt acgaaggtct tctctgtcac 9480
cgatgaactt cggagtgtac tggatgacac ctggatgaat ttctttagtg ttgaatataa 9540
ttatacagtc agcgacttga tgatttagaa tgggccctag atttattcca gaaccgtatg 9600
gatactctcc gcggcatcct gttgttacag aaatccaacg tgagtcagtt tggtgtgtct 9660
taacttctac acgaagccca cagtattttg gatgtgctaa aacatcccat gcatatgtgt 9720
acggatcatc gacatcttct tggcctttat tgacatatcc gcttagccaa tctgctacaa 9780
aaaactctgc gtacacagcg atacggcatc tttcgataac ttctgcctta tcctgatttg 9840
gattttgttt taaagagtat cttgctgtat cagcaatttt gaccttcatt tcactagtca 9900
agtcactgtt cgatagggta aatgtcggaa tctgaaatag tctctgtaaa cccggattcg 9960
ttttctgcat taaactttcc ttttacgtcg gaatcactga tgttaatata ataaatcata 10020
gtttccctta aaacaaaagg gccgaagccc tttactttat ttgaattgtg caattctttt 10080
ctctaaacaa tctgcgtaag atttcattga gatgaactgt gaaagcagca gttcttgctc 10140
aactgcacta accgttagaa actttgtgct ttctaaaaat ttgctcagtg cattaatttt 10200
gagcattaat tgatcgtatt cttcttttac tcgtgcttga taacctaaca taattttcct 10260
tagttaaggg ccgaagccct tatttaaatt gttcagtaac gtcttcaact acttcgtatt 10320
ggcaggtacg cattttagca tcgttgtaat caatcggaat tgatactaca tcacgtggat 10380
gtactttaac ttttacaact cggctggttg aactgccaaa gtgacgaata taagatttag 10440
aacacacatg tagaccacga gaacaagttt gtgtatcatc gtcattcaca cgagtacgcg 10500
acattttaac tactttacca ggactgttat caaaagtatt tgaatggcag tcaaagtaat 10560
tactgcgaac tactttccaa gcatagaagt aaccatcttc tgtaatttca atatcgtttg 10620
ctaccaagaa atcaaagagt cgagataccg ctttctggct tgggttttcc agcagatttt 10680
ccaagaacgg aaaataaaat tcaaagtttt cacctttttc catcgaatcg agaatacgat 10740
caactaaacc agaccgtaat tcgatatttt gatagaacaa gcttccgcct tcaattcgaa 10800
catcgccgga aatatatttt tcaacagcgc gacgaacatt aattttttgt gccgcttctt 10860
ccaacttatc tgctacaagc agattaagaa tttcctggaa gtttgaatga gtattaggag 10920
ttgcgttata agttacaccg tcaacagtaa ttgaaatgaa ttttttagat gcattccaaa 10980
taatgtcaga tttagcaact ggagcaataa ctgcatcgct attaacttta attgtaatat 11040
caccgctaat agtaacttta gagcgtttag cttcttcagc atttttcaaa acacgacgaa 11100
ttgtgtcaac cgatacacct tgccaatcag ccaattcctg ttgggtgtaa ttaccgcttg 11160
aatacaattt aacaatttca gcttgttcgt ttttggtcag gcatttaata ttgtacataa 11220
ttttccttat taggccgcaa gggccttcat agttttagcg atttgggaaa cttcatcatc 11280
actcaaagag ttacgataac cgatgaagtc ggaaacaata cggaatttct tggtaaactc 11340
agcaaccatt ttatcactat tttttgaagc attacgtgat aattcatcaa agagattagt 11400
tactgtccag atatcatgac cgatggtatc ttttccacca ttgaaatata caccgcgtaa 11460
tgaactaacc atattagcga gtcgtgtata ttcttcagaa acttcatctg tactgaagta 11520
cttcatcata aaatcaagtt caggatactt gataatttta tcaatatatc gctgagctga 11580
acttgaataa cctacatact tatcataatc tacatcatca aaagcatcta catataaatc 11640
acgcaaagct tcaaaaatac attggcactg accgagttct tttacctttt tctgcaaaag 11700
cggacgaata acataaaact cattaatgcc aataagatta gccatacgaa tcaaaatatt 11760
catagatgga tgacaaagag atgtagtacc atccatagag aaaatatcag aacgatgcat 11820
atacgctaca tacccagtaa tttcatctgc ttctgatgtg agcgtaaata attcctcttt 11880
ttcccagcgc ccgtctttaa tttcaaactt aaatgctgta gcagctttag gacgaggagc 11940
tttactttta actacctttg gaatatagct tttaactaaa gcttcaattt ctgacaaata 12000
atgaatgtta acttcatcac tttcaaacat tgccataata tcaggtagta aatcaatctg 12060
cgattctact tccggattaa taaacagaag acgctcattg tgatgaatat ttaaagtgtt 12120
attaaattca ctatcatcta gcgcatgtgc taatccacgg acaatattaa cacgattttt 12180
aatattatca ataacgatat taatttttgt tgtattaata ccaaacagac gataacttga 12240
tgcaacggct gaagtttcat gactttgctt aatgcgtttc agtcgagggt caagatttac 12300
ttcatacacc acgcctgcat tacataactt actgtcaggt tcaaacatgc tctgcatctt 12360
tttatatgac agatttttag tcgtgaattt gactgaatta ctaatcatat aatctcgagc 12420
agaatacccc atcttcatca attcacgata tgtgtgacgg ggagatgtag attctttaaa 12480
tcgttttaca tcttcattaa atgctttctc actaagctct ttaactcgtt caataatatt 12540
tttacgagta cgatcatcca atgaaagagc ttcacgtgat ggagcaatat caagtgaacc 12600
cattggaaac ttaatgtaat ttacttcatt gcgaatgctt agccagttac ggtctctaat 12660
aacaccatcg ataggataaa caataccgcc atagatagca tataatccac cacgatcagg 12720
ccagtatctt tctggattta caccgtaata atcatcaaaa tccggaaaat aatcaatttc 12780
gcggtcaaga ccattaataa tagccaaatc tttgaacggt cgcatgatat aagaaacttc 12840
ataagcaaag tttctaaagt ctttttcttc aactggaact acgatttcaa taccagtttt 12900
atcatctgga cccatttctt ttacgaatgt aggtttaatc tgtgggccat caccatccat 12960
gtaagctaca taaccacgaa tttcaccttt atgatacgaa gtaatactaa acgtatcagt 13020
ataactaaac ggagatttag aacctaaacc aaatccgcca atgaaatcgt tagattcagc 13080
cttagatgaa ctgaagtatg aattatacaa accaggagaa ttatcatcac cctgaatatc 13140
aaaatcactc atacccggac caaaatctcg gcaaacaaat cgtggatcta aacgtccagg 13200
aacttgaatg ataaattttt caggatttcc attgagagca tgggcatcaa tcatgttggt 13260
aatcaattca cgaacaactg cgcgaatttt gtttgtatac aaatcagatg acagaatttt 13320
aaatacttta ggagatgctg tgatgctaaa tgcttttgat ttagaaccat taccaagaat 13380
tgtttctttt tcagtggtga taatcataat ttcctcatta attcatatta cgcttaataa 13440
cttcagcaac ttctagtagt tcatctttag ttgcggtgtc ggattgaatt ttatctctaa 13500
tatctttaaa gcggttttta aattcttcgg cttctcccat atcgaaaaag cgttgaatga 13560
ttctatattc tcgatgaact gctttatcaa aaagttctaa atttacttta tatgatttca 13620
ttccaatatc ctcatttgcc caattaatta taccacatcc ttgtggtaaa gtaaactact 13680
ggctcatcca ttctttacga aggtcagcat tatctcccat gagcatttca aaaagctctt 13740
tccagttctc aggaagttta acaacatcat atactgggtt ttgaatcatc tcacgatatt 13800
cagatttttc caaagagcca agtcccttaa tataacggat gctatgttta ggtagagcat 13860
ctttggcact ctcatattca gcgactgtat aaaaccattc ttgtttttta ccgacctgag 13920
cgatgattac aggagttttg acaaagcgaa ttcttccttg ttcaaacagt tctggccaat 13980
tactaaaaaa tccgagcaga gaaggataaa tgcttcctaa accatcatgg tcagcatcgg 14040
tcataatagc aatattatga taattcaagt tttcagcttt ttcaccaaga actaatccag 14100
tgattgcgca aatatcaaat agttctttgt ttttaagcat atcagcatat gacatacccc 14160
aactgttgag aactttacca cgcaatggat aaccaccatg aagttcttta tcacgaacat 14220
caataagata tccgatagca gaatcaccct cagtcaagaa aagagtagtg tcagcatctt 14280
taccgcaaag attcgctttg atatgtttat gaactttagc tttagaagcc tttttagctg 14340
ctttagtttc tgctgctttt tctgctgcta atttacgtgc taaagcagct tcaataatcg 14400
gcattaaagt tgcttcatta tttagaatag cgcgtgaaat ctttttagca tcaagctgaa 14460
tatgactacg aatttcgcca aatggagaag tcaaacgctc tttagtttga gaatcaaatc 14520
gcatgttttt catatcacgg acaaacataa cgatagtcaa acattctttg acacgtgctt 14580
tagtgacatc aattttgaac ttacgtttga tttgtggaat aaggtcttca caaatatcat 14640
ccataacgca gtcaatgtga tggccaccat tcttagtatg aatgttattg acgtatgtta 14700
attgacgaaa accatccggt gaacgaccaa ccgcaataga acaattttct tgttcttgaa 14760
caatagcatg ctcatcatat tggcgtgcat atttcttaaa attgccctga acctttttac 14820
cattaaaggt aaattgaata tcaggataaa cgacagcaag tgtctggaga cgatccagtg 14880
taatgtcaag ataaacctga gacagctcat tagtttcaaa tgacataaaa tcaggaatga 14940
aagtaacacg agttcctttc cattttccag gaatagtttc ccaggattta ttttccatac 15000
catttgaaca acgaactaca atattatttt gaccatcgcc agtttcaccg acaaacatca 15060
cagaaaaaat gtttgtcaaa ctagaaccaa caccattcat accaccggtg acgcgttctt 15120
tatcatcacc gaagttacca cctgcttttg gaatagtcca ggcagcaaca ggaccaggaa 15180
tttcttcacc ggtaggtgtt ttaaccatcg cttgtggaat accgcgaccg ttatcttcaa 15240
ctgttacctg attattttta atggtaacat taattttatt cgcgaattta aacttagtac 15300
gaataccttc atctactgag ttatcgataa tttcatcaat aagcttaaca agaccaggta 15360
catactgaac actttcccat ttaccaaaca gaaagcgctc atgcatttca ttagcagaag 15420
agccaatata catgccgcta cgctttttga tatgttcaat atcgctcaga attttaattt 15480
cattcttaat catcacttat cctcgtttgg tttcgggaat attatactcc ggcaatcata 15540
aagctaaagg cccgaaggcc ttttatttaa aacgaatagt tgaatcctta aagaacagcc 15600
cagaacatac tgttccttct actttctgcc cagtaggtcc aatagcacga aatccagtat 15660
gttggaaatc attttcagag caaccgaacc agttatatcc agtgatttca atattcgtaa 15720
aaccactcga tgataaaatt ttagttgcat tatcagcatc agtacatcct actaaagata 15780
ctgctaatac taatgctgca atagaacgat taatatattt catagttttc acttaaattt 15840
aatggcttga aggagactaa taattctcaa acggctttct ttcatcttta actgtaaaag 15900
aaagagggtc gccagatttc atagtgatag tgcattcaaa atcaaaatct tcaggaactt 15960
cttcgaagaa gtcaaattct tcatcataaa ttagaacttc actccgcaga ctgtgaagaa 16020
tttttccagc atttctgcta gttgctgtac taatcattgt aacattatga cctttcatat 16080
cttcaacgat aaattcgctt gtagatatta cggcattaat agaaccattc ctattactag 16140
cagaaagtag atatttcttt tcttcacctt cgcgaacacg atatttctta ccgattttaa 16200
acataatcac cctttaagta aatcgtaaaa accgccattc acatgcttag gagcagaagg 16260
ccgacgagta gacaaacgat gacatttagg gcaaacatca ttttctcgtt cagaaatctt 16320
tttaattttt tcatattcat gcccgcaatc ttcggattgg catttataat catacattgg 16380
cataattatt ccttaaagtg tgctttcaac atctgataca aagaccatgc ctgttcatta 16440
ttttcaatag taactttcat gacgggaaat tctgtgaaat cttctatctg ttcttgctct 16500
tcctgctctt cagcagcctg atatggattt tccacttcat tgaagaactc ggcttcgttg 16560
gtagaaagcc agataaagtt ttcgtcaatg actgtacctt gtgttgaata tccaactatg 16620
ccagtagatg tcacaatttt agtaggacgc ccgtaatagt caacatctaa aattttaaaa 16680
ggttccatac ctaaacgccg cgcatagatt ccgttatcag tatggtcttt aataaaagat 16740
tcttgagctt gtttattttt aaattgatac catttattaa cttcaaattt aatagccatt 16800
aataaatttc cttccagtaa gttgtaccgt cttcagtgat ttcacggaat acaccataaa 16860
tcggttgttt atcaccgact ttctcataca cataaaccga agtcaagtga gtaaacttaa 16920
cggtatgttc cttttgaacc actaccaaat ctggatcaaa taatacatct tcaaattcgt 16980
cattagtgca attctgaaca attttacgtt tcattacaat ttcctcatta attaaacagt 17040
ggagcgatac gtttcagaag agtagcagca cctttggcga attttacatc atgaaaaaca 17100
gtttcttctt ccgttacaac acgaacttta atgttttcac aatcccaatt tttacgaaca 17160
atcttcaaaa gctgcagtaa atctttacat tcagcaatat cgataacaca tccacgagaa 17220
tcttccatta tagcacgata accgtaagcc ataccataat cgttgaaaga ttgctcgatg 17280
ataattaagt tttccatttt attctccaag ttgttttctg tatcagtagt tgatattgat 17340
atagtaccat aatcaactac tgatgtatat agttttatga aaaaatttta aactttatgc 17400
atagagagtg tttaatccaa ctttcaggaa tgactttgta tgttcctaaa aataccacgt 17460
tgtacaactt aacgccatct tctacccatt gatcggtaat gtatccacac atagcgcgag 17520
tataaacagc ctttccatca tctttgataa atttaaattc gcaaggagca atgaacttaa 17580
tagcttgacc gagtttccac ttaaagtcta cacctacatg cgaagtatca atcgtttcaa 17640
ttcctttagc gggaacagct ttcaaaaacg cagattcaag aaatttcgca cgaacatagc 17700
caaactgagg tttagacttt ccatctttag gaatgatacg cacttttact tcagaatctt 17760
catctttaac accatgctta agctgaatgc ttacaatttc gaccaatttt cctgctgctt 17820
tagaacggga tttattagat acacgagcaa tttcaccaat attaataatc atagttatct 17880
ctcacttgtt aaaaagattt tatactccac aggaccatta tactctggtc ccaagagttt 17940
gtaaactatt aattcaaaat agctaccact gcactacgag gtactacact aaaatcacct 18000
gcatgaacaa cgttcagaag ttcaacacca tcttcaatcc attggtctgt tacccatcca 18060
cagaccgaaa taaatggagt cttgatagct accgcacgag ttagaaggtc agtaggatcg 18120
cattcttgaa agaggatgaa ctctgcttca aaaactatag ttttaattac ttcatcatta 18180
tctaaacggc gtactcgaat cacgtaagct ttattcttat cataccagtt actttttgaa 18240
aagcttttaa ccacaaactc gccttcacca aaaacattag tcaatgcttt ataacccaaa 18300
tttagttcag tagttttaat ttcagtttca accagtttgt aggttttgcc gatttcaata 18360
gcggtagtca tagtaggttc cttaatttcc agtggtttaa cagggcatac ataagtgctt 18420
acaacatcaa aatcaatcag tttagctacc ggatttggta tgtattcagg atcataatta 18480
aatttcataa ttatctcatt tcaataaaat ctacgagttc agcatgcgat ttgcggaaca 18540
ttacttgatg cccaccaatg ataacttcat cttcaggaac ttcgtataca gcgagataaa 18600
atcctttaga agataattct tcccgctctt ctcgtgtgaa ccatctcatc atatcatatt 18660
cgctagcgaa agcaaaatga taaagagcta taaaccatcc tggaatatga tattctactc 18720
caacataatc tttcttgaac ttagtattaa ttactatatt agcgttttta actaatagtt 18780
tatcttcgtg tggtaaagga attcttttat tattatcgct atgatgcata aaattaggtc 18840
tgtcataacc tacgtgtaat agccactctt cgctacatga atctattata ctcctgtacg 18900
gcgttatttg aacacaaaga tttcgacgta ttgttatagc atcttcataa tcaagaatac 18960
taaacgatga ttcaacacga taaattttca ttttattatc ctcagtagct atggtgttat 19020
aataccacaa ctaaccgagg aagtaaacaa ctttttatcg ttttgttgga agagacagag 19080
gatcgcaatc ttcctctgac ggagcatctt caagacccat agcgtatcgc aaagcatact 19140
tcatcatcag gatgtctttc gcacagtcat gaatagaatc atgtgcaacg aatccatcta 19200
aagttccctt tggaagagga cacgcggtca tatcacgaac aaggagaagt gcttcaattc 19260
tggtacgaat atcacgctga ttccagaatt tacatggttc taacttaaat gtatcaagct 19320
cattttcgga aacgccgtta agacgttgaa tatcacgaat gagatcgact aaaattggaa 19380
aatcaaacga cattccacgg caccagcctt gagatttcca aggatcgata ttatgtgcat 19440
tgatgtaatc attaaatttt gcaataccat cgatggtgct tacatcttca tctgatggtg 19500
caatattttt tcgagcttca ggggattgat tcttccacca ttcgatagta cttttagtaa 19560
aaagacgatg tcctttttgg ctttttaaat caaatttgat tttaatgcca cgtgaaacta 19620
attcatcaaa tgtttcaacg acttctggat tagggtcaaa agcaattaca gctaaatcaa 19680
taacagctgc cttttcgccg cttcccattg tttcaaaatc tataataaaa tcaaacatta 19740
aattttcctt gctaaatcgc gaatttgacc tacagtatag tcttgaatat aaactttatt 19800
aataggctca tcaataaatt ttgccataga ttcaatgtct ttttgtatct cttcaagact 19860
gtatactatc tttgaagctt tttcgcgaat agtaatattt tcaggacccg gattttcttc 19920
aatgacagct ttaacatttg tcataagaga tttaaactgg taccaactca attcaatcat 19980
taataatcgc cttataaaga tagctaattt cgcctaaaac ataatcactg attgtaacag 20040
ttttcacttc accacaaaag aattctaacg caattaaatc tcgttcaatt tcttctaatt 20100
gaagcattaa cttgcctgat tcagttttca catttttgcg atttttgcta taagctattt 20160
cataaatttc gcttacttta tcttgaagaa gataaaactg atctttagtt atttccacga 20220
atagcttcct caaatttaat taataattta cagacacttt catctagtgt aattaccgta 20280
tctgtattac tgtgatatga ttgtttttca attcgtttaa ttgctaatat agtatcactt 20340
ataagataaa gcttatgaag gagctcagct cctgttacca taacatcgag attatcttgc 20400
ttattagtat gcttccttat accatctatt agacgattta aatattttga attgatgtta 20460
atcatatagc ctcacacata aaacacatca taacgaccac gtgttacacc aacataaaga 20520
agctgctgag ctagttcagc atctgcataa tgaatacaag gcgtataaat gaaagcacgg 20580
tctacagaca taccctgagc tttatggaat gttgatgcag gaagtgcttt cactttacta 20640
aactgtgatt tagcatccca aaaatcactc cacggagctt ttccgccttt attccaattt 20700
ttataagttt ctgccgtttt acctaaaaac aggttaaact tatatagctc ttcatcagat 20760
gaaattattt taatcttttc acgataatat tcatcatcgc cgtaagtttc tactgttaaa 20820
tcccaatgac gaattaagta ttctccagga acaccacgag ctttaacaaa cgtcgatgta 20880
tactctgctt ctataatacg aactaattgt ccgttattaa aaataatttc tgacacaggc 20940
tttccatcaa ttttatatgt tttaattaat ggttcctgca ttacaataat ttcaccgaca 21000
ataaaatctt tatcagtttc aaaaatcttt ttacgaataa tgctatttaa cttgtcaaca 21060
gatttattcg taaatgccat tacgcgattt tcaaacaaat catctagaga tttgacaatt 21120
gaaaaataat tcaccataaa atcgcgtaaa gcggtatcac cagtaaatcc acgtactcca 21180
tgcccgtcaa caattttatc ataaatccac ttaccgttac gaacgtcagt agctacatca 21240
ataataggag cattactgcg tttaacttca gtaagttcac actgataaaa atctttgtgt 21300
gtaaagaatg gactgatata agcagtattt tctcctggat caacaggtct aatttgctta 21360
ttatccccta ttccaattat agtacaccaa ggtggaatag ttgaaagcag aattttaaat 21420
agctttctat catacattga cacttcatcg cagattaata ccctgcattt agctaaatct 21480
ggtacttcct tctgttcaaa aagaacattt tcttcatatg ttaccgggtt aattttaaga 21540
atgctgtgaa tagtactcgc ttctttcccc gacagttttg aaagaatctt tttagctgca 21600
tgtgtaggag ctgccaaaat gataccagtt tcacccgtag atattaaagc ttcaatgatg 21660
aacttagtaa gagtagtctt accagtacca gcaggtccat taatagttac atgatgtttc 21720
ttttctttaa tagccctcat aacgatgtta aaggcatttt tctggccttc tgtcaaatca 21780
tcaaatgtca tcggaaagtc cctgcaattg gaatactaac aatacgccca gtatctagaa 21840
ttcgttgata taatctttgt gtatctacat caggcttaac atgtttaact tctattttat 21900
taaaccaaaa cttgcgtgga gtctcaacta gtcttggaat tcccatacct aaagctagtt 21960
tatattggtc tttgagagta gtaaaaactc tatcagcaat ctctctttca aaaaacacag 22020
caggacgatg ttcatcaagt ggaactggcg ccgtaaatcc gtctttgtct cggtaaacta 22080
tcgcatatac ataaaccata ttatcctcgg ataagtttaa aaattgaaca atttagcggg 22140
tatcctcttt tcagtttaag tttatcaata aaagacaagt tttgataccg ctctacacct 22200
tgaataattt tatcacacat atcatattgc atttctgctt ctgacaactt tttcacaatt 22260
ttccaatccg agcctttaag aagaacgttc agtttaacaa cttcagcgcc ttctgctatg 22320
cgagaaccat caatacgagc tttaagtgct ataatcctta gcttaatgtc agaggtctgt 22380
tttgatttag aaagctgaga aatgtgttca attcggtttt cacgtttttt ctgtatagct 22440
ttaatttgat tataagtctt tttgatttta gcccatttct tttcatctaa atttagttta 22500
tgaacttttt tcgcagatga acgaccaatt cgcaaagcaa ataaatcacg cttttcaatc 22560
aactcttcta aagtataatc agaacgaaat gtattatact ttttctttac tgcaataaca 22620
ttccctttaa tgtatccaat gttattatca aaacgttcta atgataattt ctctccttca 22680
atacgattat caaaaggttc tcccgagtaa gcacaaactt tttgatctaa aatgttctta 22740
atgtaattga agtctaagtt aaaatcttta gaacgtcttt ttgcagatgc ctgagtatgc 22800
tctaaacgac gtttaatttt acgaatttga ttattagaca tattatgcag tttcatattt 22860
ttctcacatc ttacggacga ttgactacta tactataaca tttttacttc agattgtaaa 22920
caactttatg caaaaatgct ttaaaaattt catggtataa tgaatctaag tccttccatt 22980
atagattaaa tccttcaaaa tcaagagtat agatagtgta tgttgaatac tttttgtact 23040
catatctatc tgcaattcta aatacacttc cagctggtat cattacttct tgttcatctg 23100
aaactaattc catattacga taacgatggc tatccggaaa cttaaagttt ggattgtatt 23160
ctttacagcg tagagctttt atagcatact cctggaaatt gaataccata ggagctttga 23220
attcaaaaat aacctgtgtg ttatactcta aaccggaagc aaaatgtaga gctatatttt 23280
tatcatatga agctgatacg actttatcaa atgtaataat atcaattcct tgatttaacg 23340
cttgcttagt ctcagctgga acacctctcc aaagaggttt atcgtttgga accaaacgag 23400
atttgattat ttcatttaac caagtatggt catctggttt gttggtaata caatgaatta 23460
aaagttcaat ttcagataaa ttaaaccctt cagaaagtaa ttcttcacga atagaagcac 23520
gcaccgatgc atccattgat tttattttaa aatcttttag ttgcattact gagtatttca 23580
ttcaactacc tcaatatcat aaactttaaa tgttccaaat gaatcgtgta atttttcttt 23640
tgaaatagaa gttattttat actttccaat tggaatcatc cattcttgtt cacgcacaat 23700
catcattaag ttatcagtac gctctgaatc taatccatca gtatcttcat acgtgtactt 23760
aaactcagta ttaggagaag aaagtataat atcgctgata tggtcagaat aattaaaagc 23820
tttatcagtt tttaagcgaa atattatttc agtgaaatac tcaacataag aaaaagaaca 23880
cgctgtatgc aaactagtag taaatgaatc taccctgttc gttgaaaaca cttctccaac 23940
ttgtaaatct ttaatgagtt cttttgtcga ttttgatata ccacgatata attgataagg 24000
cgatttagtt aaatgctttt taatgatttt attcaactgt ctgtgaagag cttcattctt 24060
tttggcttcc atacattgcc aaagaacaga ctgctcaaag tcagtaaatt tttcacagac 24120
ttttttatac atatcatatt gaaaatcaac gctttcagct tttatagata actgttcaac 24180
atctgcaaga ttaataatca tgatagcctc cgtatacttc agaagctatc atatcattgt 24240
tagaaaggaa agtaaacaac tttttgaatt attttgccca gggagcccaa ggcggagggt 24300
caagatggta tgaagctagt tcttctagaa gagcatctgg ggcttcaatt ccataattct 24360
gtaatactat acggtattct ttcttataat cactagaatc attccggata ttcgtagaat 24420
gattatcttc taacatctca aataaatcca tactaattcc tagcgataaa aaccaaattg 24480
acgattagct tcaataattt ttctttcttc ttcggacatt ctccagcgta gtccaacatc 24540
aaaatgagcc cagaccatct taacaaatgc atttatatct ttaatatctt caataatgaa 24600
tgttttactt ttagaaggtt gactcgctaa tttaacttta tcgtcttcaa acaggtcaaa 24660
aagaccatat tcacgagctc ttttatagcc tttaatagtt aaagcttcag aagaagaaaa 24720
tggtgaatca gtattctgca aaatatcttc agtatgtttt ataattagaa taacattttc 24780
tggatatttt ctttctttta tatctttaat taaaatatcc ggattttctg ctaaaggaat 24840
aattaatgag cactctttat caagtgtatt tactgattta ccttctttag acataaattc 24900
tattgaataa tgttttgcta cttcaatcat tcgatttcct cttgcctact aatggaccgt 24960
caagaatttt gttttcctgg atatatttct cattttcttc catcatttta ctgccaattt 25020
taagaagcaa atccaatgct tcatttgctt tagccttggc ctcttctaac gtcatatctc 25080
tgttcatgat ttatccccat agatgtctct catcaattta agcgctgagc gttctaattt 25140
cttttctttc tcggcactaa tcattgattt catccattct tctgattcgt tctgcatttc 25200
tttatttgcc tgttcaaccc aaccatcatc aatatactct actgaaccat tcaaacattt 25260
tcttcagaac tttcatctgt tttacctaaa acaacagtag gagcatcatc aaattcatga 25320
atttttagca aatttggatg taaactattc catacagaag aaataaagta tgataaagca 25380
tcttcactcg caattataaa tttgtttcct ttatctattt tccagttata tactgaatcg 25440
tacgaataaa aagataaggg tttatcatta tattgttctg cgctaacatt aatgtattcg 25500
gatttagtaa atgcttcaat tgctctaaac ggaatatttg gtacagtttt aataatacca 25560
atctttttaa gttttatttc agcatcttct ggaactggca ttgaaacgaa attttctacg 25620
agatacattg ggtcacaata acccttatca atcattactg ctactgtaat tggaacatct 25680
ttagcaaacg acatactatt actgctaata tacatttcaa acaaaatcgc ttccataatt 25740
ttcctcaatc gcaagatgta gatgaacaac tagaatcaca agaacttcca cacgaatcgc 25800
ccgtccatac atgaacagga acattagtgt catatgaatc agaactagac tgtgtattct 25860
gtgcattaga tgatgtagta ggtgttgacc agcgccaagg atttttataa tattcctggg 25920
cttcttcata agtcatagta actgcttcta ctgttccatc tcccatataa acatattcaa 25980
ctacagttaa aggaaggtag tcgtttgaaa taggaactac accttctcca ggagctgtag 26040
agaaaaaatc cgtaaagaaa tttttaaacc agttaaagat aaacattaca aaaagcctct 26100
cttgaattca acttgcttct caccataatc atatcgaatc tctgcattaa attcgacaga 26160
accatctgcg tacatcataa atgaatgcac aacaacttct gtagaccatg gctgtagttc 26220
atatttcttc attacatgcc gtgaaatgat aatatctaaa tcttcatttg gtttaatcca 26280
acgatttaac atagtgctct cctctataag ataattttat tataccatac tcattttgga 26340
aagtaaaccg gtaaaatgaa aaaggactcc cgaaggagtc cttgaaatta ttcaccagtt 26400
actttccaca aatcttcgtt tgcagcaatc cacgcagcac gttgattttc ttcatataca 26460
gtagtatatg ctgctttttc tgaagggaat gtctggtaat gagcaccaga aattttgtga 26520
acgtcagaat aaagagggaa agctacagaa atttcctttc cttcaatttt cttatttcca 26580
tctaatttct gctcaaatgt tttgatatta acataaccgc gagtactagc catgtaattc 26640
tccttttatt taaattacat gattatttat aataattctc gcggctttta agtcgtcgtt 26700
taaataaacg agctattaat aacctcggtc ttgacgagcg aagttttcag cattcttcag 26760
ataataaagt ttaaagattt cttcagcagt aaggccgaga ccttggaaca tgttcagaac 26820
gaaatgaaga atatcaatca tttcgaattt aatttccaac tggtcttgtg gagacaaatc 26880
agtaatcaga gtttcacgac gttcaccatg ctgcgacttc caaggcttcc atacagcaga 26940
tgcatctttt tcgccattgc tcataccacc aagagatgtc agaagttcac ggaattcatc 27000
gtcaatataa tctttctgat tacgcagcca atcgacaact tcacctgcag tagccaaatc 27060
atcaggatga cggttatatt caggtttatc tttagctaaa cgaacctgca aagatttctg 27120
catatcaagc ataacttgca gtgggtcttt ttcgtcaccg agaatatccc aatattcatt 27180
ttgagcttta tcagcgcctt cgatcagttg cgaacattca ttaaagtaag ccattatttt 27240
tcctttcaat tcatgggtta gtagattaat tatacaataa atatataaag caataaggag 27300
gacatatggt acaaaaatta atggcacttg ttaatgccat aaaaggtaat aaaaaacgta 27360
tagcttttac tatttctgct atgataggaa ttttactctg gaattttgtt ttatcaccaa 27420
ttgctattgc tcatggcgtt aatattccag taattactct cgatacattc gtagatttag 27480
catttgcttt ggttgggtta atttaaatct tagcatattt agatagccgc attttagcca 27540
tcaacccttg ggcaatatta tttttcatat attccataat ttgttcaggg gttgcacctt 27600
cctttctaat catatcatta acatcttttg atttccaggg agatttgtcc caaaacataa 27660
ccctttctcc tgcatcaacc aatttagtca ttcgtttaat agtgtcagga tgacgaggtt 27720
cattatctaa aacccataca cgtctatctt taaatggaac aatttctagg tctaattgac 27780
cacccgtaat agctataccg ttttcaataa aaagtgaatc tataggtcct tctagaacat 27840
atacatcacc atctttaacc cgttcaactc catagatttt tgttgcctca ggataagctt 27900
tgatggtgat atatttttga ggagcatctt tctttaatgc acgtccttga aaagactcag 27960
cttttccatt agcattataa attggaataa caagacgagg ctcagatatt tcctttttat 28020
atgttcccgg tgctatacta ttaactaatt taggccattc ggttgtaaac caaagatatt 28080
tccatttatc ctttggaata cagcgagctt ttacgtattt tataattgga tggtcttccg 28140
ccagtttatc taatctaata catgacggaa gagatttaat tattttcttc tcaggttgtt 28200
tagaaagttc tttaggtttt tctactggac gacttttacc tttttctttt cttatttcaa 28260
agatatactc acgatataaa tcaggttcaa actcctttaa atatattccg attggtgcat 28320
gatagttaca gttataacaa tgaatatttc cttcattatt atcaccataa taccatccac 28380
gggctttatt ttggtcggtt tttgaatctc cacaaacagg gcatctaaac cgcaatttaa 28440
aagttgaact attatttact tgtgtgaatt taggtaaatg agctaatgca cgatatgcaa 28500
actcattatc aatccaaggt attgatgaca tttttactct tctttttctt tagattcctc 28560
ttttttcttt ttaggaatct gttcaggacc tttatttact acagcgcctg acgttgttcc 28620
agtagagata ttttcaggat taccacctga atctccagcg accatatctt ctttaataaa 28680
ttctttatat gttttcatat taacctctat tcataaaagc attaaaattt ggtcatcaat 28740
agaaacattt actttagact gtttttcgga tggtaattca tatccacata ttacaatttt 28800
gtgatcaata tcaaaataca cagaagcaat atgattaatg ctgttttcag taaagtctaa 28860
atcaacatca atatcttttt gaccaaagcc caaaggataa ataatgcgag taattcgatt 28920
atctttaaca aagattccac cgacatactc tgtactgcgt ttaaagtcta cacgccgacg 28980
aaatgaaaaa tattcaggct ctttatgagc tcggctcata ggacacaacg agtaactaga 29040
ataagagatg tcaaatccta caccttcgat atgagccata gcgtcatgat taaaccaatt 29100
ataatcgtac gccaaatcca ttagattata atatgtaaaa ggcaccggat taacatcatt 29160
agtcacaagc atgtaattag caactgctat aatttcattg tttttaacga atacaaaccg 29220
tgattgatgc gaatggcctg gacctgcgtt ttcacgatta atgatataac actgggcacc 29280
tttatatttg tatgtatctt tgcacttgtg catttgatag agcattattc acctaccact 29340
tcagcgatga tatttttgtt attaaagttt ttatcgcaat acagaacata attatactgc 29400
attacaccac cagacttaag ctgtttttgt acttcagctt tcatttcagg acgatcgcgc 29460
tcaacgatat tcataatatc cgcttcaatt tgagtttcaa cctcagtctg atcagcagtc 29520
atagaccatt cacacaaatc tttatcataa cctgccatag caggctgagc agcacaagaa 29580
gccaaagcaa aaattgtagc aaaaataaat tttttcatga taatctcctc agtagtttat 29640
gtttatatag tatctcaatt tccaacaaaa gtaaacagtt attttaaaac ttctgtgtaa 29700
tcacatgtta caaactgttt ctctagcttg acgattttac gaaagtatct tttacattga 29760
cgaatctgtc gcttagtagg gcgcacagca aacttaataa attccactcg accaaatgga 29820
gggctttctt ctgatggaat atctaacacc aattcccacg tatctgcaat aagtgctttg 29880
aattgagtat ttttcctaac gttatacgga gtaggtttaa ataaaacaat atgcatatta 29940
tcctcggcaa tccacttcac atactttctt gtcatcaatg aaagctttaa ctaatgcttt 30000
attaacttca gcatactgag tagtagccca ttgaacgtca tctttcatca ttgtggtttc 30060
tttagtaaac atgctttcat tcttaaacca ccccataaaa actaccttta ccaattccat 30120
aacaatctcc tcatttaacc aacaagacta ctataccata gtcttgtcag cttgtaaact 30180
aaaattttaa ttcatttgcc aaagcatcta actgagctcg agtcgattcg tttctttgat 30240
agcgattctg ctcagcttgt atctgttgtg aacctgctac ctcactcact tcagttggag 30300
tagaatcttg ttcaatttct acccatttct gatttccttt ttgaacaccc atcaaaaact 30360
tattccactt gttcttatca ccatatcgtg atttgatttg cttaatgagt tgttgttcag 30420
cagctgctaa ctcctcggtt tcaatgactg caagcataaa atcagctgtt gctggaagac 30480
cggcagattc tgcaatatcg ctcatgttaa catcagaaga atcccaagct tgtttaccaa 30540
cctgtgctgc agtccaaaga acagtttcgg tttcaacagc cagagcacgc aattcctctg 30600
caatagcttt aacagttgtg taactatttt ctgaataaac tcggatgcga caagatttac 30660
aaatacccag atagtcgaca ataatgattg ttggaacaaa attcttcttg agcttcaatt 30720
cgtttaaaag tgatcgaaat gtattagcat ctgctccacc ggtaggatac tgtttaacga 30780
ttaaacgacc gagagtagat ttctcacacc atttttccat ttttccttta tactcagcgt 30840
aagaaatatg cccatcatca atgtcatcaa gagaaacatc aagcatatta gcatcaatac 30900
gcttagcaca gacttcttct gccatttcca tggagatgta aagaacatta tgtccgagct 30960
gtaaataatc tgctgccaat gaacacagac ctaatgactt accaacgtta acgccagcca 31020
ttaaaacgtt cagtgttcca gtctcagctc cgcctttagt aattttgttt agaattctga 31080
gtttaaatgg aaccttacga gctttattca tataagatag ccaacgtgct tcgtagtcat 31140
ccatccaatc atgaccaacg taactatcaa atgaaattga taatgcttgg cgcatgatgt 31200
caggaatagc accaacatcc ggcattttct tatttcgttt ttccggagga agctcagcat 31260
tagtttgaat ttcgattatt ttagacgtag cattaaacat cgccctttgc tgaacatatt 31320
tttctgtttc ttttactaac caactgtggt cttctggaga atcggctagt tttgaaataa 31380
gtgtttttac accagaatat tctgtttcag taaatgaact attttctaat gcaacattta 31440
acgcattaat agatggaacg ctatggtact cattaacatg agatttaatt aatttgaatg 31500
tatttttagc tggaccactt tcaaaatatt ctgaatccat atacggccaa acttttgaaa 31560
aataagcttg atcaaatatg agatgagaaa gaataatttc taccacactt actccttaaa 31620
agaatttaaa ttttttcttt gaccttttat taaatgcatc ttgtagttgc attgtaatac 31680
atttttctac atgaggagct aactcagctt ttctttcttg gtcaagaaca gcaaagtcca 31740
ttacgacttt tccatcaacc caatctaatt ttgtcacata cacaatgtgt gtagaaccat 31800
cttctagttt aatgacaatc tcctggataa cattttccat agcggattta attatcttaa 31860
gagactcatt aaaaagacgt tcttttcttt cttcttcccc ctccgaagag ggggattcat 31920
cgataatttc tagatctaag tctaaatcat ctttattcat taaattcttc catatcactt 31980
aactgttcga ggtcagtttc taaatcagca gctgatttac ttttactttc tggagattta 32040
aatttttcaa cctttgagtt aatcaattca tcaacttcag cttcaacaat ttcattacta 32100
tcaatagcac ctaactgata agcacgttta atagcatcac ggaatggttg atgcttaaat 32160
aaaggacccc agaatgtagt gcagttggta tcttttgcgc gccaagattt ttcttcgcga 32220
atcatctcac cagtttcttc atcaagaaat tcacgagcat accaaccatt tttaggtttt 32280
accacgaatc ctaattctag agccatatct aacaatccag aataaggatc gataccgccg 32340
tcaaatttaa catcaataaa gaatttactt ttttctttaa cggtacgaga tttttctaca 32400
tttagaacaa attgataccc ttgaagatca gaaccatctt taatctgacg tttaccgata 32460
ataaatacgg tatcagccga atacattacg cctgtaccac ctgtcatcac ggttttacta 32520
aacatttcaa ttgtttcaat tgtatggtta accgcaacac atggaatatt tttaatgcta 32580
aagtaaggag taacaatacg gaataatgac ttcagtgatt tagcacgagt catatctgcc 32640
acagattttt cattcaaggc atcttcagtt tctttcttag aagccatatt accgattgag 32700
tcgatgaata caataacttt ttcaccgcgc tcaatagctt caagctgatt caccatatca 32760
atttttagct gttcaactga ctgaatcggc gtatgaatta ctcgttctgg gtcaaccccc 32820
atggatcgca aataagctgg agtaatacca aattcgctat catagaatag acaaaccgcg 32880
tcaggatatt tgttcaaata tgccgcaacc atagtcaaag acatatttga tttaaagtgt 32940
ttagaaggcc ctgcgaaaat agttaaacca gactgcatac cgccatcaat cgcaccagaa 33000
atagcaatat taagcattgg aatttttgta cggattacat ccttttcatt aaagaattta 33060
gatgtagtca gttcagcagt cattttagaa gtggaagctt taatcaaacg ggattttaaa 33120
tctgcaatag acattcattt tttccatagg catcattata ttttcctcac tggttaaaga 33180
tagggtaatt ataacacaat aaatttaggc attaatcaac tgctattgga tgaatagcat 33240
taaacttatg aaatgcttct gatttttctt tacgcgaaac acacatgcga agaaccttta 33300
atggttcatc ttcttcaccc aacgattttc gtttttcaat attagaagtt ttccaacgag 33360
cttgctctgg aaactctcta ttgatttgct caagcgctct attatgttta gaattactac 33420
gaattgaact gcacccgcca ggagcttgtg cttttccgga tacaaccaga tatttgaaca 33480
aggccaaatg tggataacct tgattaatta aattgagaaa tgcatacata tcttcgcata 33540
aatcaatttt tccataccca atttgttctg tcgtaagttt tccgaggtca taccatgtat 33600
tcgtgaatcc atatgaattt tcacgataat taccccaaga tgaagtaatt ttaaaaatag 33660
gtagacgagc atggccatga taatacccac aatccatggc atcctcaaca tattgaatca 33720
attcatagaa ctgttcacga gttaattgat tgactttatc tacgcagcgt cgatcatctc 33780
tttttcgcat tgaactcata cgaatagtag tatcatcgtc aatcatccag attcgttgac 33840
ctgcatacat atcagtaatt gctttacgag taccggcaat tccgtttaca tcatcaggaa 33900
tagttataat tttagcttta gacccatagg catcataata agctttttct tcatgttcac 33960
gcactacaat atggggttca taatcagtcg gaaacatatc aagggcagaa actgccccga 34020
cacgctgata acttggaatt acgaattgaa tcatttccac tcacctttat agtctttttt 34080
cacaatatga gtttcgccag tattccacca atgatcaacc aagtaaaaat gacgagaata 34140
tacatgaaga cttccaacat tccatataat agaacctgct ttatactgac gagttgaatc 34200
gcctgcattc aaatcagata ctaatttatc taatacgtat ttttgccatg cataatcatt 34260
acggaatccg aagaccacgt catttgagcg catgcttact actgcattga ctttcttatc 34320
acgaatcagg tactgtactg tattagtaca catgaaatct gacataccat ctttattgta 34380
gtcaaattgc atagatggac gagtataaat catgatacca cgtcgagaat caggattttg 34440
accaagttca gctaaacaca tatcatactg agcatagtta tcttctgacc agatagccca 34500
accataattc gagttaattt cacctttaga agatgctact tgttgccaaa tcttcggtgt 34560
ttcacctgga atatctttaa caaacaagct tttagattta taccattcaa gttcacgctg 34620
aatgtattca tcattaagag cgccaaaaat aaacggttca tctgctacaa atgatgcgcc 34680
aataatttca atagttttaa caccagtttt atcaactacg aaatcttttt cttttaatgc 34740
aagccccaaa tgaagacgga tttcttcaac tgtcatagag tcactaatca tttaaacctc 34800
aattgataca ttcatattta acttgtaaca gtaataaact ccaacctaaa ataatagttg 34860
gaatcataag aggaaccgtt acactatagt atatacttat tataatcatc aagattaaaa 34920
gcaatgctgc tataattttg cttttcattc cttctctctg atgataatta cctgatttgg 34980
ctgcgcagac tttttagttt caccagcaat tgaccaaata aatgtaataa accaaccaat 35040
aattgaccag ttaaacagta aagatgtgaa aaagattcct actgtcgatt ttgacccacg 35100
catcaaggcg ataaaccatg gaagcatgta tataataata gccaacacgc ctgaaactaa 35160
aaccataaaa attgaacctg ctactaaagt ttccatgttt tcctcactta gtcaaatttt 35220
ttacacatga attataagaa ttcactacat actccatcgg agcattttta ccagtacgcc 35280
attggtaatt attagcccaa tttgcccaaa gcatggcgca gtagttttca attttttctt 35340
cgcgtgtaat tacatctgaa ttacgatatg cttgagcaga ttcatctgga cgaatagctt 35400
cgtcaaaatt cgcctgcatt tgttctactg tttgctttgg agcttcttta taacacttga 35460
tattaggatt ataaaatttg cttgaacagt ttacaatttt tcctgcatca gactgattta 35520
ctaccggtcc ttgagctaca caaccagtaa gacctaatgc aataaccaaa atagcgattt 35580
tcataataat ttcctcaaat gcaagtagta attactccag tagtgcttat gcaggtatta 35640
cccatttgca cacctaaaga tccatttgta ttcacatgaa gattatcgtc aattttaact 35700
gatattttac cattagtgtg aataacggtg ctagattcaa tcacaggttg agtatcattt 35760
tcaacactaa caaatggaac tgctgctaat gcaactaaac aaactgctaa gcatcccata 35820
acaattttca tttcattctc caaatccgta tcagtagttg atagttgtat agtaccatag 35880
aagaacaggg atgtaaacag ttttgtgaaa aaatttttag ggaatccaaa gggtccagaa 35940
tcatctcttt ttcataagta tagatttata ttacttgtat gaaaaaggga cccggaggtc 36000
cctagattta ttctatcagc caaacaggaa gtctaacgaa gctttttctt catagtccat 36060
gccagccgat tcacacatac ccgcaagcgg tttaacaaac gatttttgga acaaagttga 36120
gtagtcaatc caagacagta cgtcagaacg aatttctttt ggaagttctg tacccgacgg 36180
ccaagcaatg catttgtcac caaatggatt tccttcacgc aatggaagaa ccattacttt 36240
atttccatcc aaaattggag ctacacctaa accgctaaca gctcgacgat aagttagcac 36300
accgcgaata tggaacgggc atttaaatcc tggccaacct ttatcatcat atttcgctat 36360
atcgttcgca gtttttactt cagcaataac tttatagtca agttgacgat attctttctc 36420
gaagttcttg tagtattctt ggacagactc ttcaccttct tgaagaatac gacgaatact 36480
ttcttcgaga gcttcttgca ctgcttttgg tgttgaactc tgctgagttt ccatacccat 36540
gatttttaga tgcggttcag caaatcgttt atcttccata tcataaacgt tcagagcata 36600
acgctttttc gctttccaaa atccaccaac accctttgaa ccaagtggag ggcaagaaat 36660
agcttcacgg tccatatgca tcagatgctc gcggttattc atataatcac ataactcacg 36720
atatgcaaca tcaatcatag gttccatctt tttcttaccg aactgattca tgaattcaac 36780
taaatcgttc tgctctttga atcggtcaag accaactttt tcaataactt tatctacaca 36840
aacatatacc gaatcagtat cacctgctgc gatgaaatct tcaccattag ttccgcatac 36900
tttattcaga tattcattaa ttttacgagc aatccactga ataccaactt ggccgaaaat 36960
tgtgatagca gtagcatttc gcaaatcata gtaacgaaaa tgaatattac caagagcacc 37020
gtaaagactg ttaataagaa ttttacggtt cagctgattt gtgttagcaa gtgtagctgc 37080
tttttcacat tcttcaatca aactattgag aacagattcg gtgtaattcg atagttcatt 37140
taagaaatca tcactgaact taacatatcg ttcaacttca ggtttagttg aacaagaccc 37200
tgcgcctttc ataataatct ttttaatagc ttcggcattc atttcttcag cgaacatttt 37260
ctttttccaa tctttacgct ggaaaaatac tttagcgatt tcctttggaa tgataccttc 37320
ttgatgctta tcatacatcc atccattcgg agaacaagaa tattcatcac tcggtttagg 37380
agctgttcct gcaatatatt catgaattgg atgaacttta aactgcccac gaatagtctc 37440
aggactaatg ttaacctgac gaataatgct cggatacaga gacgtcaagt caaaactcat 37500
aatatatcga cgagcaattg gtttaggttc aaacacaaat gcacccggaa aactctgttt 37560
aacgtgcgaa ccctgttgag gaataacctt atgttcacct ttcaatgagt taaaaataat 37620
ggcatcccag gttttaatag gactcattac accagaaaaa ggcattttag cgtaataaga 37680
catacttaaa actagatcga taaacccgcg aattttatca attgcttgaa ctgattctac 37740
gtcaatgatg ttataactaa tgtatcgttg atgattagtc tcacgaagtt tattaatagg 37800
accgtcgtat ggtaatttac cttttttggt ttcatgctga gcaactgatt ccaaagagaa 37860
tgacggcaaa ttagtaaatg cgaatttctt atacaaatct aaataatcaa gaatagatac 37920
gccatcaata gaataaattt ctttgctacc gtacatattt tggataagtt tagattttac 37980
tcgaccgatt ggagagaagc gtttcatact acgttcaccg agaaccattt taacgcgatt 38040
catgatatac ggaacgtcaa atccctcaat attccaacca gtaaaaatag caggtcgttt 38100
ctgttcccaa agattaatat attccatgag catatcacgc tcattatcga atggcatata 38160
aattactcgg tcaagaattt cttgaggaac ttcatcacca ccttcacagt caagcttagc 38220
agctaacttt gcatcccatt ttgatactga accatacatt gaattcaaaa ggtcgaaaac 38280
ataaaaacga tcgtcaattg aatcataatg agtgatagca tcaatttcat attctgcttt 38340
cattgggtca ggaaatttat caccagtaac ctcaatgtca cagttagcta cacgaacaaa 38400
ttttcggtca taaacaattt ctgaaccata tgtatcactg atataagcga gtttaaaatc 38460
gttcataccg agagcttcga gaccgatgtc ttccattctc ttcatccaat ctcgagcatc 38520
tttcattgat ggaaattttt gaggagcgca gtttttacca tagatgtctt tgtactttga 38580
ctcttcctta caatgcctaa acatagttgg aagatattct acttcacgag tacgttcctt 38640
tccgttttca tcaatataac gttcaacaat gttatttccg actgtttcga tagagatata 38700
aaattctttc atagatattc cttagtttat agcccgagtt attaggctct tgatatatta 38760
tactccaaat aaggggccga agccccttgc ttaattacca atcgtatatt taggaacgag 38820
tttccattca tgtttttgtt taaaagaaat aactcggaag ttattagtta aatctttcat 38880
aaaagttctt tgaccaggga cgatttcaat cagtccccaa tcttctaaca gccatgcaat 38940
cgaatcacga cgaacttcat cttcttctgt catttcaact tgacggccat ccatacgaag 39000
catttcttta aaatgaacga tatagtatag tccttttttc tgaagaatat gacaggactg 39060
atacagaact ttatctttat tattagcaat tcccatacga gtcaaagttt cttttacttt 39120
cagaaaatct tcaggttttt taagagtaat ttcaatcatt ttaccattcc aatgctagtt 39180
ttttgagttg tttctgttct tttacgttct tagtcacttc tttcaaaaaa tcatccgtga 39240
ctaatccttt aagttctttt aatactaaag gtagttttcc atttttagta agaattgatt 39300
tatagttaat tgcatcattt gtattaactt gataacgctt agcaagtaac ttaataatca 39360
atacttcggt ggaatcttca actagttttg cccatttacc atatctttta ccacgaggaa 39420
ctgcagccat tagataatta aaatgggctt catcacttaa gcctgatcca attaaattca 39480
tagcatatac agccggcatg cactctggaa attgtgataa tgcattttca accatgaatt 39540
ttgaataatc tttttgagca atagagcatt tagttttatt attaatagct ccaattattt 39600
caaaaaactc attttcagct ttttctttaa aagaatcagc agcggattgg acagctgtcc 39660
aatcttttga ataccaagca acttgatgct cgtttaattg aatatcatct tcaaataagc 39720
tcatatcact tccactgcat ttcacatgct aactgaatga aaagataagc taaatgcaat 39780
tcagtattag ctgcaatacc atgatactga ttattttcac caacaatttc atacatacga 39840
ataatacttt gcggagttac gcgtgtatag atttcttcgg caagtttacc tacgaaccac 39900
gaataatcag ctgcatattt tggtgctaaa gctctgagct gtttaacatc tttatttttg 39960
agagactcaa gaacatcatc aatagcacca cgatcgttag taaccagtga taaaatacca 40020
gcatccaaaa cacctttaga tgaataacta tcgagctcgc caatagtttt acgaaaatca 40080
ggaaaattct ttttaaccaa agctgctaca actttcatat cagctatagc aattccttca 40140
tgcttgcaga tttcagtcaa tcgacgaatc atctgcttca tcatttcaat tttatcttca 40200
tcggtcggtt gaccgaatgt aataactcgg cagcgtgact gaagtggttt aataatacca 40260
tcaatattgt tagcagtaat aataatacta cagtttgaac tataagcttc cataaaggaa 40320
cgaagatgtc gctgagactc tgctaaccct gagcggtcaa attcatcaat aacgattact 40380
ttttgacgac catcaaatga agcggcgctg gcaaaattag tcaaaggacc gcgaacgaaa 40440
tcaattttac aatctgatcc attcacaaac atcatatcag catttacatc atgacacaat 40500
gcttttgcta cagttgtttt acctgttcct ggagaaggag aatgaagaat aatatgtgga 40560
atcttacctt tacttgtaat agatttaaag gtttctttat caaaggcggg aagaatacat 40620
tcatcgatag tagatggacg atatttctgt tcaagaatgt gttctttttc atttacggta 40680
atcataattt cctcattcaa gttttagtgt aaattataaa gggccgaagc cctctattaa 40740
aaatcgtggg tagaatcagc ttcaagagct actacataat tcgcgtgttc accttcaaat 40800
ttagcagcac cttgtttacc ttttgcccag agcagaagtt tataatttcc tggttgcatt 40860
ttcatatttg ccatattgat aataaaatta aatgtatttt caccatcata atcaccaaga 40920
gtcaaagaat atttaacacg ggtcagagca gaatcttcta ctttattaaa accgttaatt 40980
acgattttac cttcttttac cgtgatagca attgtatcaa tttgcagacc acgagataca 41040
cgcaacagtt gttgaaggtc ttcagcttta atttcagtaa caacagatgc taccgggaat 41100
ggaattggtt tattaggagc aactactgta ctcggatcgg ctgctggcca aaaaattgtt 41160
gaacgagcat cagcaatttt aatattacca tcttctgact gggaaatttc tgcatcatca 41220
ttaactagag acagaatacc gagaaaaccg ttcaaatcgt aaattgctac atcaaaatca 41280
ataacgtcag aaatattcgc ttctgcataa gttgtaccat taaccgcacg agtcataata 41340
aattgaccgg atttaagcat aataccagag ttaatagtag cgaaattttt cagcagagca 41400
gtagtatctt tagacagttt catgtaattt ccttcaattc aaatgagatt taattttata 41460
actaatttaa taaagcaatt aacgattaaa atcagccgca attgtttccg caacaatttg 41520
tgcagcaaca attagacgtt catctgcatt accacaataa tcgtcttcaa ggcgttcacc 41580
acatgaagtc ataataaatt tagcaccggc gtttagggat tctgcagtat gtttgcgcat 41640
tagttcaatc catttatcac tcacttcgcg atcgatggct tcataatacg catggcgagc 41700
aggtgcagat ttaattttgc tctgaataac ttccattgcg ttatcagaaa gagacaaaac 41760
ccatgctcga cgaattttat tttggttttg tggatttgat tcagaacgca cgtgttttgg 41820
ctgaatatct tttacatcaa cagtataatt cacagtaatt ttagtcataa tacaccttta 41880
gtcataataa tcagtaacag tccaagcttc atttctattg gacattattt ttgtatattc 41940
tgctttaaat gcattcctaa gcatagattc agtaactata tgctcttcat tagaaaaatt 42000
atttctcaga atatatcgtt ttatttcagg aaaagttaat aaatgctgtc cagttgaata 42060
ttccatgttt ttcctccata gagattatac tctaataaat taaagcataa tctcttataa 42120
attaaaccat tacagtaaat cgaccaactt tcttcatttg aagatgctga ccatattctt 42180
gcgggtcatg gtctttatgc gaaattataa aaacattagt gtttttcatt gaatttataa 42240
tattagctac acctttaata ccttcggcat caaatgaccc atcaaacact tcatcaagaa 42300
ttaatgtatt aatactaaca ccagatacga tagaagcaat atcacgccaa gtaaataaaa 42360
gagcaatatc aattcgtgcc ttttcacctt cactaaatga agcataacta aaatcttcac 42420
gaccacggga tttaattgtc tcattaaatt cttcatctaa tgtaaacaca taatccgctt 42480
ccattatttt aagataatgg ttaatctgct tattaaataa tggaatgtac tttttaataa 42540
tagcaccttt aataccagaa tctttgagca tatcagtcaa aattcctcgg tggtattttt 42600
ccattactaa attagttttt gtcttaacaa ttttatcaag ttcttcttga agcaatgcta 42660
tttcatcagc atggtcaata aactcggatg atgctttttc tatagctgct ttaacttttt 42720
tagctttatc tactgtcgtg attagagatt gctttttatt gcgaatatca tttgccaacg 42780
actgctgggt tttaatatta tctcggtatt catcaacaag aacttttaaa ttatcacggt 42840
gcgttgaaag ctgttcaaac gaatgcgtac attcagaaac tttatcttta attttagaaa 42900
caactttatc accggaactt aattgtgaca aacaggttgg acataatcca ccttcgtgat 42960
acatattaat gactttatta tacgagtcaa tttttgattt aattaaaaat gcttcttgac 43020
cgattttatt aaatgcatca gtcgggtctt catccaaaac aatattaact aatctttcat 43080
tagcttcttc tatttccgat tttaacgttc tagcttcttt tgccaaatca tcatacatat 43140
tttgcagacg agtaaggttg tcacccgtta attttttctg gcgttcaacg ttatcattat 43200
atattttaat ttgttggata atactatctt ttttaacatc aagcacttgg ttttgtgaat 43260
ttaattcacg tattagtgct ttattaagct tatccatttc agctaatgtt cctacctcaa 43320
gcaggtcttc cacaagcttt cttcgcgcag gggtcgacaa acccatgaaa ggggtatacc 43380
ctgctgtacc aaggacaaca atctgcttga aactggcata tgacattccg ataagctgtt 43440
caaattctgc ttggaaatct ttactgctgg cagattcatt aagacgtgta ccgttaacgg 43500
tgatttcgaa aacgtttggt ttttgtcctc ttttgatata gtactttttc tcatcatatt 43560
ccatccacag ttcaactaaa agttctttct tatttgtgct gtttattaat tgacctttct 43620
ttacatcacg gaatggcttg ccaaaaagcc caaatgtgat ggcttctaac atagtagact 43680
taccaccgcc atttcggcca gtaataagag ttttttgaac cttatctaat tgaatgtcaa 43740
taggatttcc acctactgac attatatttt gatacctaac tcggtttagt ttaaaattct 43800
tcacaaaaga ttccttttaa tgtatctttt agaccattct atcatatcat cataatctaa 43860
aaagtattca tcaaattcag ccatgcaaac aacgccttgt gctgtttttg atgtaatata 43920
aattattcca acatatctag aatcttcttc ggtataatca atgtttgcta tgaattcatc 43980
attaatgtca aatgtcgaaa acttcacagt atgcatcctt aatacaagat acggccatat 44040
ctcgcaatga tttaggtgtg tcattatcta aaatgttgaa gttaaaagat acagcccagt 44100
cagtgcagac cgtgaccttt ttaatacaat tatcttcaac ctctagcggt tcaaaccaat 44160
attcaataat ttctttatgc ccaatatcat cttttacttc gcattcaaaa tgctgactca 44220
tcataacatt tttaaattca tcaaaagtca ttgtgttgcc tctacatata actgatttgc 44280
atattgaata agtgcttcac ggtcagaatc agtgatgtct ggaattgcat taatgtattc 44340
ttccatcaac gtctgaagag attgaacttc aacttcttca ctgtcatctg actcgacaga 44400
gttatcaatc tttgacacaa ctcgtaatga atgcacaact ttttctagtt cagattcgaa 44460
cttcgttaga tttttgtcta cttcagttac tataacacgt actgatagat ttgtaaaatc 44520
tttatagtca atttttcctt taaatggata atgaattcta cgatgccagg tagtgttgtt 44580
tggaataaat tccattcgtt ctgtttctgt atcaaacatc cagaacccac gagggtcatt 44640
ctcgtcacct gcagttagtg tccatggtgt cccaatatat ctgacgttag cagcctcaga 44700
gatagtatgg aagtgaccag accacacctc tttataagtc ttaaggaaat caggttcaag 44760
accgtgagat ttcattcctt tataaaaata aaatccattc agttcccagt gaccaacaca 44820
aaaagaagca gatgaagttt tgatgtgctc aagaatttca ccagtatttt cttcgcacat 44880
ccaaggaatt aaatcaatca aacatccgtc aaaatctact gtagtaggct tatcatatac 44940
tttaacatta ggatatttag ccaaaagctc agtagaggca tttggatgca ttacattttt 45000
gtagtggaga tcgtgatttc ctacaatagt atgtaatgtg attccagcgt catcaagcat 45060
ttgaactatt tcacgggcaa actccatagt tttatgtgtg attgcttttc gcacatcaaa 45120
aatatcacca tattgaatcc atacagtaat tccatttttc ttagaatatt ctatcgcttg 45180
cttaattcca tcaatttgaa taccgcgaat ccactcatca tcagctttaa cgcctaaatg 45240
ccaatcaccc aagtttagta ttttcatggt gtcttttcca tcctaattta gctgcttttg 45300
aaaccagttc tttaattttt ccttttgtcc attcaggacc aggaggttca tgacataaca 45360
tttgcttaac tccgttatta taccattttt tacctttatt atgtgatgaa gctttaaatt 45420
tatttgacct tccttttaca taaccttctg gaatataagg caaaaaggca gattttcctg 45480
ttaatggatc atgtgaatgt atatttcctt tacaattatg agaaccatat aatggatgat 45540
tttgtccttt attatctctt ccaaatgaac cttttggagc agcatatgac atattaaaga 45600
ataatggatt tttaactgca tcatgcaatc gttgataata taactcgcat ttaatagctt 45660
cttcacgcgt atcaaattca gctaaaatgc atgaatcaaa taagtgagga ttatctgaaa 45720
gctctttatt ataaattttc ttatactttt tagataaaac tgaaccatga tatccagcta 45780
aatgcctatc taaagacgta gatccaatat aaaaaggagg aagtttatct ccactatata 45840
ttgttaaata agttatatat tttttcatat atcaagaacc gtcattgaaa tgcaaaataa 45900
aattattgaa ataaacccat ctggtgtgct aaagaaacca atccagcatg ctctagtgaa 45960
tagataaaat gcaagaaaaa gtatcacata tccaagaaat atcattatat caaactccgt 46020
ataaagctaa agggccgaag ccctttattt tgtaataatg tcaaactgtt ctttaaagca 46080
gaagcttgaa tcttgatgct gatacaaaaa ttcatatgct ttttctcgct cacggtcata 46140
aagagctcgg tcagatgaca gttctttaat acgttcaaac gttgattcca tatcattttc 46200
atcaaaccaa atgataccgc tatcatgcga ggtcaaagga gtattatcaa cacggaattt 46260
taaattttcg ccagtagatt tccaaaatac cggaattgtt ccacatgcac caagctcgag 46320
atgagtatat tctaaagaac gttgtagata ttttttatcc aacttactca gctgataacc 46380
aaatccggat ttactcatgc gttcaagcat ttcgctattt acataacggt caagaatttg 46440
cgttggcaaa ttaggagcaa ttttaatttg gtctacttga tgaagacgat aatactcgta 46500
tggaattcct ttttctttaa taggaatgaa cgctggagaa cgttccagac cttccataat 46560
agtacttagt cctgcaggtt taagatgttt ttcatgaaaa tcaaacatct gataaaaacc 46620
tttccatgta gtcgtacgac caatccaacg gttgatattc atgttaattt cagaaacatc 46680
tttccagtag gttgatctaa ccttcgcaat atccatagga ggctgaaagt tatatactgt 46740
cggtgcttct tcaatatcat caaacagaga aactgtttca ggataccatt ctttcatcag 46800
aactttatta aaatcaccat tatcagaatg gctaaaaata acatcagctc gacgaacagt 46860
ttcttctaat cccaaatttc gacgcaaaga aagagaagaa tggtcatgtt gataaactac 46920
aacacgaaca gaaggtttaa tgttatcaat aattttttta tagttattaa tagtgtcttc 46980
ttcaaccgaa gtagcaggaa ctgaattaat aattagaata tcacaatcat ttaccagctt 47040
aagtgtttta tcatattctt ttgccaataa aaccggaatt gaaaatgatt tataatcatg 47100
cgcgcaatta cgagtaaatg atttatcttt agcataaacc aaagttactt catgaccatt 47160
tttaataaac caatcacgct gctcaagaga aaatttagtt acaccgcaac cttcaagacc 47220
ccgagccaga aaaatgcata ctttcattta atatcctcat tgttttggtt tattttacca 47280
aaaatttata aagcaatata ggagccgaag ctcctatcca cataatacgc catacaaagg 47340
ctcattagag cttctaaatt ttctgcgcct atatgttata gttccttctg ctttagcttt 47400
atcgtaagac tctttaaagc gtctcatcat ttctacttta gaggaacgaa ttttattata 47460
atctatttca gaagtctggg tgttcatctt tcataactgc caccattttt tgacttgata 47520
agaatcaacc cacactttca tattagggtc tgctcttaca ataggaggat taacttcttt 47580
aattgaacta tcatggtatt ctttttcaga aattttcaca caaagatgac cattcaaaga 47640
ttcagtaaat cctgcattaa ttttaagacg cttgaatttt acgtgtgtaa gcatcaatca 47700
tatcctcaat ctgcgatcta gtagtcttcc aaagaatact gatgagttca tcgttatatg 47760
gctgtttcag aatatcccga cttttcttga tagcatattc gtattgagca aaattattgt 47820
tttcagctgc gatctgagcg tgcttataaa gacgattcag ttcgcgtttg tttttagaca 47880
ataacttatt tgcttttctt tctgcttcaa gacggttctt ttcttcaata gaagaaataa 47940
gcttttccac ttcatcatta atttcgggtt tatcagtcat attatttctc taatataaaa 48000
taaaaatcat catctgttaa atgatacctg taatttaatt ctacaccatt agatttaaaa 48060
gcggtatcat acggattttc tggatcaata tcaatgtcaa gagctaaaac ttccctgaga 48120
tacattttaa gtaaataggg aatagcttca acttcaggta tttcttccaa gaatccggag 48180
aggttaatcg ttagcctcat ataaaaaatc caaactagga gaatcgtcta caacactttt 48240
cttttcagcc cccggtgttc tataggttga ttcttcgtaa tgcgtcattt tatcgtagat 48300
gtcttgaata aaagtttcat ctactaacgc aaccatatcg tcgtcacgac tgtcatagac 48360
attgtgaacg aagtaactgt atttctttgc aacttcctta cgttcttttt taatacgttg 48420
gacgaatgca ttaaaacaag cttgagttat atatgcatgt gggtttttat atttcgtttc 48480
atcaaaatta tgaagcccct taatagaagc ttctatacca tctgcaatca tttcttgttt 48540
ccaggactgg gtgtatcctg aaaagttgaa acgcttagat aagccttctg caataagcat 48600
aatggctaat ccgatagtat cattctgacg aactacttta tttgggtctt tattatttgc 48660
taattctgtt ttccaatcaa taatagcttg taaaagctct ttattgttta cgtaattata 48720
tttaggctta gtttctgaca ttttcacctc ttagctcaat tcatagatct attatatcat 48780
aatatttgaa gatctatctt aaagcataga ggatatcagt tatctaagta agcagtatgc 48840
ttggaatact ttctccatca tctttttaaa ttcatgaata tctatataat gactagttag 48900
atcagcatga tataaaaagt ctaaaaactt ttcatgtgtg ctaacatatt cgctttcatt 48960
taattcagaa acatggcttt cccaatatcc aacaccagtc ttatttggga aaaatgaaat 49020
tttcatgtat tggtcaacat agaaaatgcc ataattttca atagtaatag aaatattaat 49080
aaatttcata cattcatcaa cttagccgct tcaagagctg catctagtga atcaaattgg 49140
tcaacatatt caatcaattc gccgtaattg gcatataacc accattggct aaattcatac 49200
tcaaggatga atccgtttcc ttcaatttga gttaaaccaa tgccatttat atttacttca 49260
tatccagcaa gacgcaaatc gttaataaga gcttcgttca taattatacc ttagtaattt 49320
tcaggtctgc aaattttttc ttgcgttgat ttttcatacg acgaatagtt ttatcggaaa 49380
tttcatgctt ttgataagct ttagattcta caccaaaagc tttaacatca aattctgaca 49440
agatatattg aaccagcaat tcacggacag tattgcgtcc aatcttctga tcattctgtt 49500
tcatcatctg atgaagctct ttttcccatt tatccaaaat ttgaggagtt acaatatcgc 49560
ctttttctag caaagaaact actttatcat atgcgtaaga attaatgacg tttttaattt 49620
gaatagtcat acattatcct caattacgtt aaaattttat tatccaaaaa gggccgaagc 49680
ccttagctaa actttttggc acccttccag ccttcgtaca tcattgcgac tgacaatgac 49740
aaagctcctt cacatgctgc atacttatta ttccagaacc aatttagaaa aacttcatcc 49800
tcaataccat tgtgtttcat gttctggaaa aaattggcgc gttcttcacg aagcttttgc 49860
gataatttag attcaggatt catttaaatt tcccaattac cattttcatc aataaattta 49920
atccagtcat ttactgacca cttggtcgta tcgccttttg gagcaacatt taaagtgtat 49980
aatccttgtt taaaaagcat tcgtttgata ttcatatttt cctcagctgt aacgatagca 50040
ctcgtttgat ttgcgcttag caactcgttg agaagtattg taatcaaaat catcgtcaat 50100
gtaaactgat tttttcaact ttcttacttc accacgtaat tggcggattt agctcatctt 50160
taacttctga atcaatacct ttcattctac gccatttatc agagcgaaaa atgttttcaa 50220
ccatatcttt atgacttaca ccatcaggag ctttacgctt tccgaaatag tcataatcac 50280
gcacttttaa gtctttacga cgatacgttt tacccatgga gtttaatttc cttagcaact 50340
gaactaaata cagcacgatc gcaaatcatg cgtttatgta acttgagtat aatatagcaa 50400
acttcaaaac tatttacatg agtaacacga acagcattac cattaatgag ataatactgt 50460
ccctttttaa tttctttatc aaccataacc atatcaattc ctcaaaggca attcatatgt 50520
taataatacc acagtttgag cttgttgtaa acaactttgt gaaaattatt ttagggaatg 50580
ataagaaggg aacgatagct tagaatggta atatacagaa tgtgagaaag aaaggcccag 50640
agggcccgtc ttagtcttct atgatatctc tatcatatcc aagtgaaatg agagtttctt 50700
tgaagtgttt aatgttcttt tgtctagaat cattaatgaa aatgactgga taacgaatgt 50760
taagagatgt gaatccagcg cgtttagcaa gagatacaat cagcggacga tcatactcaa 50820
tcttaccgtt atttgtaaga actttataga aagtaaaagg agcattaagc tcctttagaa 50880
gttttgtaac tgattgacat ccaggacaac gacctacttc ttcggggatg ccatagattt 50940
caatcttatt ctttaaattc gagttttgtt ccacgagaaa taattccttg ataagcccag 51000
tatggcgggt taacagaatc ctcaccagag ttttcttcag gaaaataaac ctggataacg 51060
aagccggatt catcaaaggt gaaataagta gtaggcagtt cacctaacaa atcggcacga 51120
gcgttgattt cttcgaggtc ttgttcacgt ccagcccaga agcttgggtt cagactacat 51180
tcatagaaat aatagtcatt accgaacata tcaaaaccat tccaactctc tactacatac 51240
cgctcaaaac taatcataat taagcctttt tatcaagaac agcattcagc ttgttagtaa 51300
ttttatccag acgctcattg aactcgctag aagataagcc tttttctgga gaaattaagc 51360
taatcacgaa aaatatagca ataaaaggaa taagaaaaat agcaccaact gccataaaca 51420
gaaagaatgt tacagttgta agaaaatcag ctaaaccttt acgaaattta tacatatttt 51480
acccttaatt gattaaccaa gcattgataa gcactaaact atattgggaa taaaattctg 51540
gaccaaaatg aaaaatcata tcatttatag tatccataat gtaattcaat ttaatcatgt 51600
ttccacaccc catcggtatt tgaccaaagt cgctgattat ctgatcctcg ccacagcttt 51660
ttggtcggaa gatttttctc atacttccca tcaataataa catcaacata tttaagcatt 51720
tctagttgtt taatatcttc aaacttatat cctgtccaca accaaatgct tttattggga 51780
taaagatttt taactgtttg aacgatgcaa tgaatcacgt ctctgttatc aggataaaga 51840
gggtcacctc cggttatagt taatccttct atataatcat tattcaaaca ttcaattaat 51900
tgttctagtg tttcaccagt gaatggaata ccatttctag cattccatgt tgatttatta 51960
taacaccctt cgcatttatg caaacaacct gtaacgaaaa gaacgaccct gcatccaggg 52020
ccattaacaa agcagcacgg gtatattctg tcataattca taataatatc caatttttcc 52080
aagcttcatc agtagaatta cagcgtttta gtataagatg tctagaaact tttatggcat 52140
ttgagcactt tttaattgaa tcatatttaa taccgtcaac tgaaacggtt ttgctaattg 52200
gagaaatttt tccatacatt ggattttttg aaccaacttg aagtcctttt aaagcttttg 52260
aaagcttttg tctagattcc aatgacatgg gagaattctt tttaccttca ataattcgct 52320
tgcgatgaag ttcgcgttct tcttcactca aagaattgta atatttttta acaccgtttg 52380
atatagataa tttatctttc tcagaccgct ctccagctaa tttacttcta acatcttttc 52440
gcttcatagc tatgcttacg gctttattta aatttgcttg atgctctggc gtacgtttat 52500
atttctttaa agcacgtgaa atagctattt tagtttcttc tgttctcttt ttacctttat 52560
ttgctaaact atttttgcgg cgatgttcaa gtgtctgttc ataggcagtt ccaccttttc 52620
caccaggttt aatattatat gtattttctt ttagacaata ctcttcggtt acaagttcag 52680
cttctttatc atacatctgt ttttcattat caaaaacatg taaaatttct ttattaaaat 52740
tttttctacc atattttaat aaagcggcac gaatcaatgt tcctgacccc atataaccgt 52800
catttatgtt atcggtgcta tgcgcaccga tatattcctt tgaattaatt atatttgtta 52860
ttttataaat tatataatac ctatgcatgt tttactcgtt ttaccatttc tttcatttta 52920
cctaaattcc atggaacaac gctaggagtt ccaagatatc cgcatgttct tcttattgta 52980
ttcatctttt taggatcagt ttctccacaa atagaacaaa taaatccgct ttcagtagga 53040
gtcatttcat gggtgcttcc gcatgtaaaa catttatcta ctggcatatt aacaccaaaa 53100
taatctaaat gttgtgcagc ataatcccat acggcctcaa gaccctttaa gttatttttc 53160
atatcaggaa gttcaacata agaaatgtga ccacctgtcg caatgaaatg atatggtgct 53220
tctcgagaaa tcttttcaaa cggagtaata ttttcttcta ctgaaacatg gaaactgtta 53280
gtgtaccagc ctttatcagt aacatccttt acacttccat atttttctgt atcaagttta 53340
cagaagcgat aacaaaggtt ttcagcagga gtcgaatata aactaaaagc aaatccagtt 53400
ctttcagtcc actgtttaag atgagcattc attttagtta aaatttcttg cccgatatca 53460
cgtccaacaa gaatattcaa ttcatgaata ccaatgtatc ctagggacac tgaacttcta 53520
ccgtttttaa ataactcaat tatgtcgtca tcaggtttaa gacgaacccc gaatgcacct 53580
tcttggtaaa gaataggagc aacagtcgct ttaactcctt ttaaggaact aattctacac 53640
atcaaagctt caaaacacaa atccatacgt tcattgaata attcaacaaa tttctgttcg 53700
ttaaattgtg ttccaatata agaatctaat gcaatgcgag gaagattcag tgttacaaca 53760
ccaagattat tacgtccatc aagaatttca ttaccagtcg aatctttcca tacgctcaag 53820
aaactacggc aacccattgg agaaacagga atagatgaac cggtgatagc tttattattc 53880
ttaactgaaa taatatcagg atacatcctt ttgcttgcac actctagagc aagctgctta 53940
atatcatagt tcggatcgtc tttataaaga ttaacgcctt cttcaacgaa cataacaagt 54000
ttaggaaaaa taggagttat cccatcacga ccaagacctt taatacgatt tttcagaatt 54060
gctttctgaa tcattcgttc agtccagtca gttcccgtac caaatgtaat tgttacaaag 54120
ggagtctgtc cgtttgaact aaagagagta tttacttcat attcataagc ttggaatgca 54180
tcgtatacgt ctttttctgt tttagattgg gcataattca gtgcatcggc gatttgccat 54240
ttttctgcgt cctcgatatg ttttgcatag gtgcgtttaa cataaggaga aagtacttta 54300
tctacattag caaaagtcgt tccgccatat tgatgggaag caacttgcgc agtaatttgt 54360
gccataattg cagtagcaac gccaattgat ttaggagttt caatctgtgc attaccaagc 54420
ttaaatccgt tttcaagcat tccttttaaa tctactaaac aacaattagt aaatggaaga 54480
gcaggggaat aatcaatatc atggaaatga ataattccgc tttcatgcgc tttcataata 54540
aaagacggga ccatattttt ggcaatgtgt ttagacacaa taccagccat aaggtcccgt 54600
tgagttggaa aaacacgaga atctttatta gcattctcgt ttaaaaggtc tttattagtt 54660
ttatgaatca atccttcaat ttctttttca attgtcattt taaactcttt ctaagctgct 54720
tcttaaatga agctattaat tgtgttttgg tgtcaaattc attatattca aatcctcttt 54780
gaagcatctc agccatcatt tcctcttttc ctaaacgaga aaattccttt gatttatctc 54840
caacgaagtt agggtgaata ttattttggg tgtaatcgga ttttaaataa gtaagtaaat 54900
tttctaacca ttcaagataa tcaacaccct gtccctttaa tccagaacga ttaaatttat 54960
gcttcatttg accttctgca gcattgcaga gattacagag caatccacgt acctttcctg 55020
cttttggtcc atttaattca tggtcatggt caaggtgatt agcttgaaca tcaggattta 55080
attctcgttg gcaaattaag catttaccgt tttgtgcatt ataaaatttc tgtttttctt 55140
ctttatataa tttgccagtc aataacataa taaaaccctt accttaaata gataagggta 55200
tttattattt tcaagtattg taaaacattc gatgcaatcg cttatattgt cgaatcatct 55260
ttttagtagg acgagaatag gttcctacgc aagtggtcat atgagggtcc gtagaatgtc 55320
ctttaataaa aagtttccaa accttaccgc catttaactt ttcagtataa accaattcgg 55380
ttttcattaa aatgtcctgt cagaaaaaga attttgagtt ttttcaagta ttgtaaaaca 55440
tttgattcaa tcgcttatat tgccgaatct tttggtcaga aaaagaaatt tgagtttcaa 55500
gccattcaat gtactctgcg gcagcttgca ttaaatttcc ttcataacca tcgttatttt 55560
cttgtgcagc taatttagct aatgcgtatg aaatacgttc accttgaaaa tcggctttag 55620
gcttctgaac aacttgatta gttcgctcta caacttcttc aatttcgcca ttttcgactg 55680
attcagtatt ccacaagcac caatacgtaa ttggcttatc atagatgtta ataatctttc 55740
cgtcggaaag ttcaatttca ataattccag tatcaggctc tatatcatct tcacattctt 55800
ttgcaagttc acgaacttta aagacagtac ctgcactaag ttccggccag taattacata 55860
gccctgtatc aacacgatta attctaaacc acttatctac tgtaatcatg tcccatctcc 55920
atatcaatta agtcatttat tgtaggttca ttatatactg tttcttcatc agtgtaaacc 55980
ggttcttccg gctctggctc tacagtttcc catctaaccg cccaccaagg tttaaccccg 56040
aagcttatta agttcttcat aatcaatcca ggattctaat cctgatggca aatcagattc 56100
aatttcccaa agaagctctt caattttctg aagacgatct agttcttcgg ctggaatagt 56160
aaccattgac ggagttcttg atacactaat atcgtaaatc atatttaccc cagtttgacc 56220
atgcaatcgc cgtatttcca cttagaaata gacttttcgc cattagaata ataaacttcg 56280
agtttagcac gattattttt aatttgaata accttggctg tcatcaaagt tccataccca 56340
taataaactg caacctcatc acctacatat accgcgcttc cgcggtagtc atggatataa 56400
tcagttcctt cgagcatcat ttaaagtatt cccgcaattg gtcaaatcca ccaatatgac 56460
ttccatcagg agcaaatacc tggggcattg tcaatccaat ttgagtatca cgacctagtt 56520
tagtcagaag ctcagcgatt ttctcatcat caaaaacacc tttttccggc ataatgttaa 56580
taaattcaaa cggctgtttc ttcacggtca aaagacgttt tgcattatcg caatacacac 56640
atttatgaat gttgctatca taaccatata ctttaaacat attattcctt aattcctagt 56700
acttgtttaa aagtctcgtc gtaatcaaga ctttggcctg tttgttcttt atgtttgtat 56760
ataatatcac ttacttctga tagcatattt ttatatgaac gagttaaagc agatttaagt 56820
acgctgtacc tatcaggaaa tttaccatgt tcattataat aagctattgc taattcacgg 56880
actgcctttt cagcagcctc catatattct ttacgcttgg tcatttttaa tccaaaatat 56940
tattaggcat tggttgaaca ctcacaagtt ctttaaagaa ctcagtagag tcaggcaatt 57000
taaccatttc cggagcatgc ttactgaatt tatgtttaca ttgacggcat ttatattcaa 57060
gctctggttt acgccagtta atcaactgaa cttgttcagt accgcattca gggcaattag 57120
gaacgttttt agaagctctt tcacgtcgtt caaccatagc cataatagca tcccatgctg 57180
gaggtttaaa atctaaatca tcgcagccgt gaatctttcc acgcatttcc atatcatctt 57240
cctcaccagc cataataatt ttaattagac tagaattact tgaagctgca atgtcttcta 57300
ataaacgctt tttcatttca atacctcaat agcattacgt aaaccatttg ctttggcggt 57360
taaagcctta agaactttag tatgctcttc aatttgtttt tcaacttcag tcaaacgggc 57420
attgagatat tcacgttctt cacccagatt atcaaccttt tctactttag gctcttttac 57480
aactgtctta tatgtattag ggttcttcag tttaattaga atgcgtgaac tgtataacat 57540
tgaaccatta tcttcggttt cgtcatacat ttccactacg tccataattt ttaacatcat 57600
gcggagttta taagacaacg aacgaatagt tttgttgtgc ttattaattt ctttagctgt 57660
catggtgccg agattacgtg agtaataata aggaacctgg atattaatta atactgatga 57720
accacctggc ttgtgtgtta cttcatcagc aataacccaa tccttaacat gaactgtatt 57780
tgtacggtca tcgcccgcgg taaatagttt gcgagcatgc ttaaaaagca tattcacttg 57840
gtcattgaat tgacaagcaa atttatcagc aaatttagtt tcaggaatgg tagataacca 57900
atcagccaaa tgggtctttt taacatcgtt aacaatagta aattcaacca aatcggttat 57960
agatgtcgca gatttaatga agctcggctt cataaagttt ttaatgttat cgcgagctac 58020
ggtagaagat aacatacgag aacgtttaaa ccattcaagc aaattgccta acgaatgaga 58080
ataagcgttt tgagtatctt tacagatatg attttcctgg ccaacatatt gaaggaaatc 58140
acgaagaata ttattgatta ctgctctgtg cccgatctga taattacggt gtttagtaat 58200
aagactgtca aaataatcaa tataatgttt acgagttttc atgttcttct cacttggtta 58260
atgatttata ctccgagcca tccttggctt taaattactt aattaactgt aaagcttgtt 58320
caagacgatc caagcgatta acagattctt cccaaatctt tttagccttc tcatattctt 58380
tctgcgcttt attagaaatt tctagaactt ctttataagc tttttctagt gcaacaactt 58440
ctggacgaat ttctaccggt tcaggtgaat catcaagatt atccattagt tcctcaaggg 58500
tagtttcttc tttaggagta ttcacaattt catcacattt ttgttgataa atttctttat 58560
cagtaggtga gtacgcgcac tttacttcac gaagactaat tacaatttta tatccttccc 58620
aaccgcatat attcttaaaa ggatatgtat gaatattttc tactgtttcc atacaaagta 58680
atgcggtctc taattgacga gttatagtgc tagcaattga gaaaaattta ttaatattct 58740
tttggttagt ttctggtgta aaaaatccat aattcacaaa aatagatact ttatttttat 58800
caagttcata ttcttttatg ataatcatat cagaagccaa aggatgaatt tgacgataat 58860
cgccataaca taatttagaa gctgatttta gaatctgtcc tttgaaaagt ctgaaattac 58920
taatccaacg acgagtaaaa atattctcag ggtcttcttt attattaaga tgataagaat 58980
taacatcacc gaaccaatta tatcctacta catctttggt tcgtttaatt tctttcccaa 59040
aattaccaag aatatcccga ttaaccaaat atgaaagaag acgagactct ttaaaggttt 59100
tcttgataac atctttatct acacggctag aaattttacg aatttcatga ataaatttag 59160
tagaagaaac aatacttgca tcaacactat tgagccattg attgataata gaaagaacgc 59220
tattctgact agacacaggt ttaactttat catcaataac gctattgaat gatttgatat 59280
attcgttacg agtcataata atctcctcag tagaaagtaa gaacattata ccacatcctt 59340
gtggcaaagt aaactagttc agtgcattta gtgcattgtt cagtttagaa cgttgcttcg 59400
taagattttt gactttttct tgagcttttt ctagcatctt ttcagcttct agcacttcat 59460
tggtcacttt aacgagttca tcatctactg ccttaagaga cttctcaatc gcatcggcgt 59520
gccatttttc tacaggttta aaatttgaat tttcagtagg aagaaaactc actttattaa 59580
gtttacatgc atctatattg cttgagctat acatccaaaa tttaggatcg tttgatgagt 59640
aattggataa atttaagata tcttgcactt cctgcttttt ctcttgcggg acttcgtcct 59700
ttctcaaaaa atcgtattta aatgaaacga tcatatcaag ttcatatgtt gttgtgtcta 59760
atttaaatcg ctcaaaacga ggtaaaatct tagactgaac agcggcaaca acatccatat 59820
acttaaatgc ttctgtcaac tgcgatttaa ggcattcgca aattgaaaga gaattttttg 59880
tattaggttt aaagctaatt cgcgcagttc tgttattttc ttttaatggt cttacttcca 59940
tctgaagagt ataaccatca aatttcaggt tctttaagtt aatgtcagaa ccttttaatc 60000
gactagcagt cgacaaaatt tgctttaatt gtctacggaa cagagcaata aatctccatt 60060
caatacgata atgatttgga ttgaaaaatc cagatgataa atcgacctta ctttgaccaa 60120
cgccttgaac aaatagagga tttttataat caatagtttt acagaaatct gtgagctgct 60180
cacgagcagt catttgtgta atataccccg ctttactaaa attactcacc cattcactgc 60240
tatttagata tttaaagtga tgaatagcat gattaacttt atcagggtct aaattatttt 60300
cacacaaaaa tgtcataaca ttacgagtat cgctggcagt acgaaccata tcttcaattt 60360
gagaacgagt tttcatggta ttccttaaga tttaagtaaa tcgacaattt taattaactt 60420
ttcacgctca gatttagctt tactactcaa tccagatagt ctgaaaattt catcatcata 60480
ttgttgaata gaaacattca gctcttcaat ctgtttatta aaataatcaa tttgttcaaa 60540
atgtttttcg ttactatgaa ctggtacagg ttttgtaggc aatgtagttg aactggattc 60600
atccgggcga taaattaaaa tacaacttga accaataggg cattttgcac cagatgaata 60660
ttctaatgtt ccagattctt ttaaaacttc aaaagctaaa cagagatgat gccccatatt 60720
aacataatct gtagagtgag ctctgatgta ataatcatcg ccacgagtac taaatttaaa 60780
gcatttaagg tcttctgtat tattagtctt aaaaatcatt tgtttatcta gacctttagc 60840
taatcgagcg cctaatgcta ataatcgtct ttgattttcc cacaaatccg caatcatttg 60900
atcgaatgat aattttggca ttagtcgacc ataaaggtca tatcctttat tataattacg 60960
aaggatttca ctcgcgttaa tacgagacaa tgctccaatt ttattaaggg ctttcataat 61020
gcgattagat aaactcattc cagacccatt tgttcgctgc aaatgttttt ctaatccaaa 61080
tccaatatca actttaaact tatctaaaat ttctgcatga acatctctgt caataacatt 61140
caaatccaaa gttgggttaa atctatgaaa aaatttatcc ggctctccac ggcgaaatac 61200
agtccattca ttcatcattt ttttattaac taaagattta attactgcat tgacattatt 61260
aattactact gacatatttt cctcactcaa ttttactaat tacgcgaaat aagattgaac 61320
agactatata agtaccgcat atagactgaa ctaatgccat tccaaagaac caaataatat 61380
tatcaaacca tgtctgtttt acgtcgaaag gacgtaaact tacagtaata ttatcacctt 61440
tttctattga agaatacatc tctggggaaa tatattcact aaatctataa ccgtctttga 61500
gttcatatac ggcaataaac gataaactag acccttttcc ttgtgttcct gtaatggtat 61560
taactacagt aacatcataa tctttataat gcatataatc attaattgcg taataaccat 61620
atgcaattac tacacataaa caacatatca ataaattcaa tcttttaatt atcaactgtt 61680
tcataataat ctcaattaaa agggcttaga accattatac catccttggt ataaagcggt 61740
tatgcgagta ccgtctttaa ccgttcttca aacttccgaa gagtattttg gcgttcagct 61800
ctttgctttt tgtaagtttc aatacgctct gaaatgagag tgtatcgttc atttactgat 61860
tctttcataa aatcaggaat ttgacgagaa gctttaatct cgtcaaattt atcaataaca 61920
gcttgctctt cagcaattaa gttatcatac attaaaatat ctttcttgat gaactcaata 61980
tcttcttgag ttacacgaga taatttagat gctttatcct ttttgtactg ttcgttagta 62040
tcacgagacc agtgtaatgt acgattttta ttcgtattct tataaatttc tacaatacca 62100
atctcatcaa taataacgat ccaattccaa cgggatttgt aaatttgtcc tccatcaaca 62160
gtgatttcac ctccgattga gatgtcatta aagaacttgc tttgtgcttc agatttaaat 62220
ttaccatcgt tgtaatttac caagttgaaa atatctttag cgttcatttt ctgttcctcc 62280
gtagttgata gttgtatagt accacagagg aacagtcttg taaaccacta aaagaaactt 62340
ctttcacaat tttttccact gaaccaggcg ctcactgctt tcttggtctc aggagcagtg 62400
ttatccataa accattcaaa ggcagccttt ttatgattct ggagggcttc tcgggcttta 62460
atctgctcac ggtctattaa cactaacata tgagcctttc ttgtcaccat gggcttctta 62520
tgattttttg aatactccca gtcatttgtc catcgcattg ttgttgcgaa ctgaaatact 62580
gcttctttaa ttttagtttc gtaaatttca cgagcctttg agtataacat cactacctcc 62640
attcatcagt ttaattctag tcatcttttt aatggcagtc catataatct atttctgaac 62700
tgcctttttg tcatagaagt cctcttatga attatttcaa aagagtaacc tcagcaattt 62760
cttcccaacc gtttttgtcg gtcataataa agtcagcaag ataaagagca gtacgcagtg 62820
aaacattgcg taaacgatta acattaactt tcatccatga taatgcttta taagtttctt 62880
catcagaaag accgcgcttt tgcatcatgt cagttgaaag aataacatct tcaaccctga 62940
ccataatttc ttcattagtg tgaacaccca aatctaaata aaccgagcgg gacactaatg 63000
cttgtaaatg tggagcaagt ttagtaccac ggtctaattc gcggtcaatg tcaacgtttg 63060
tgataaaaac aatcgttcct ttaaattcaa actcacgctc aatgcctttt tcttctaagt 63120
aagaagacgc agtgctccag cagactttac gggtctctcc agtgtccaga gcggctttta 63180
gaagattaag aatgtccata tcagagaaaa catctacatc atcaatcaaa aggacagaat 63240
tctcttcacg attattccaa agctgctcat aaagaccaat accagagatt ttaccattaa 63300
tgcttttata ttcaatgtat ccaatatcat ttgctttatt taaagcttta tctaaagaat 63360
acgttttacc aatacctgct gcgccagaga taattaatga acgaatattt ccgttaataa 63420
taccattcgt catcattccc ataacattaa atcttttatt aatgcgggtt ttcatatctt 63480
catatgattc tttaacttct tcaactttta caccatcata tgaaatatct gatttgtaaa 63540
cccaaacacc gcgacgttta ccgtcaattt caacaaaaac tttaccatct ccttgtgcat 63600
ctaccggagc attatctggg aaccattcgc ctaagagctc aaaagttcca gagatttctt 63660
taccgaagta gataccctta ttgatagtta cagttttcat tttattctcc aaatccgtat 63720
cagttgatag ttgtatagta ccataaagct ttatgcttgt aaaccgtttt gtgaaaaaat 63780
tttgaaataa aaaagggagc ccgaaggctc cctatcattt ataataactt cgatggtttt 63840
caagataaac cctctcaagg aagtcatccc agaaacccat gtctactttt tgctgcatac 63900
cgttcttaga agcttcaatg gatgctgctt ctacttgatc gaccacatct tccaaaaact 63960
cttgaacagt tttaaatgga tgtttaccca acttcacgtc gagaataaat ggagcgtctt 64020
gaagtggata gactaagtca ccagttttgt aaatttccaa tagttggagt ccaccacggc 64080
aagcatgact cagagctttc cagtcaatgc cctcattcgc ttcagcctta cgagcacgtt 64140
cgccgtattc agcatcaagt ttattcaaag actgcttaag ctcaataaga gaaagcgttg 64200
tttgatattt acgacccaac acagtgtaga acgtttgtgg acctgttttc tcatgattat 64260
ggaataccca ttcacagaat tcgttctctg gaagacgatg cttaatatct tcaactttag 64320
ttcgacgctg cttaatggaa ccgtcttctt ggtaatcaac ccattgctca gggatttgat 64380
taactacttt caacacatca cgtaatgcgg ccaaacgaga acccttaaca ccgtatttag 64440
aagcttgctt gcgaacatat cctaagtagg atttcatgtt ggtcgtataa aaacgagaac 64500
ggttgtcttg aataaacttc catacatcag gcaaatcaga tttaactact agttccggtg 64560
gagtgtggag catatccaat gctacagttt caccatctgc tgctaattta aagaaatact 64620
taagactgta tagttcatgg tcaatatcat ctttagtgtt tttagatgat gtgttgttag 64680
tgtttttact catatgctct ttaacatttc caataagaat atcgcgagca ggaggaacaa 64740
agatttcttt aaaatctaca tcagattctg gagtagaagt tccataaaga tgactaccaa 64800
aatagctttt cattactgtt ttcatcattc agccttatat tcaataacag gacatacttt 64860
agctttacga gcttttaaaa attcaacgat aatcgatttc ttgggttgaa taggaggtaa 64920
acctttatac gctctatcaa tattttctac gtgtaaagca taatcctttt tccatttata 64980
atctttatat ttttcacgca aatgtgcagg aataacaaat gaacagataa taagtaaaac 65040
aaccaaaagc gcaagtataa atgccgatgg aagaagagtc cataaactac caaaaataag 65100
ccaacgttgt aaactttctg cacagataat tgttagccct acgagtatag cacatccaaa 65160
aatagaaacg aaaaatgtag gaatggcaat agaccaaaaa tatgcgcata gtgtcttagg 65220
tcgttgccat tcatcgttaa acaatttgaa taatttatag tgccaagagt tttcattaat 65280
aatcataatt atcctttcat tgaaggcgta acggttgtta aatacttaat catagcttca 65340
gcttctgatt ttgacaatga aatttctcca ttgttttgac gaatagaaat aaaatccgga 65400
tgacggtcac caccagcttt taaaacacac atataagtat cagtttcgcc ttcaatattt 65460
gaaatgattg aagcagttcc acatgaatgc ggtttttgat aaatcaatac agcttttctt 65520
ccgccatttg gactgctcat aggcttttaa tacatcaaac aaatcagttc ttttatcaat 65580
agctaaaatg ttattttcat cttcaatgtt aaatccttcg gatacttcat aaagtgtcac 65640
ccataaatcg ccaatatcaa taacagcgtt cacttttcca tgactttcaa gagcatgaca 65700
aattttcttg atttcgtcat aactcatttt aataatatca tctccttgaa taagaaagat 65760
gtcattttta aattcaacac gaattaaacc acttccactt gaaataaaca tatttcctca 65820
ctttgaaatc atagttggaa tgacagaatc aagataagtc tttagcgcaa tagcttcgtc 65880
tttggtaaat gtgacaatat gtgatcgaaa atcgtcaatt tggcgaatag ttaagacatc 65940
tccctcttca taacattttg atacatttaa aagagtttca tcattctgat tgcaagcgtt 66000
agtaataata gcattgcaat ttttgagcca ttttaaacta tgttttcttt cattagaata 66060
ataaaatatt taatcttagc tataaaacta tcccaatgga taactgataa acacattgac 66120
tcgcttttaa tattaaatcc tgggcatgaa gaataaaaat gaattttatg ctcatcatta 66180
atgcttacaa ttttatcagt gtaagcatat tcaatttgag ttaaacgaac aatttcacta 66240
ggtgtaaaat acagcatatc gtcttcttgc gtcaaacgat acatattatt tactttttct 66300
atagccaatt caccaaaaag tggactaact tctaatacta atcgtttcat attaatcctt 66360
tttattggca cgaatttgtt ctaaaatttt agagtattcc tttgtatcag atttacgtac 66420
aatcgataca ctatacggca tactatcggt gtcttttata aagcgttcca aatgacattc 66480
taataaaatt tctggattat aaatcgtgta catcaaatta cctgttgctc cacgatattg 66540
acagatttct actgattgaa caccattcca taattttgtt aagaccaaat cacctacttc 66600
taatttagga aagcccatgt tattcaccaa ttaaagtttc aatataagaa tcaagattta 66660
ctttagcttc ttccataaga gttttgtatt taatcttgtt ggcatgtccg gagaaagctg 66720
attcatcaat aattgttgat gtatgaacag ctttactata cgtctcaatt aattctctta 66780
atttaaaagc ctgctcactt gtcattacat actcctctga atcatatcaa taatgttgtt 66840
caccagatta taagtaaaca ttgggtaatt atattgaatc atcacataca caacaaacaa 66900
aactttcatt ctcttctcct tggcagttga caagattact ataccataac cttgtcaact 66960
tgtaaaccat taaatgacgt tttcgataaa attctgaagc tttgtatgag catcaaccat 67020
gattttcatt tcttctttgg caaaagctgt gcctctttca cgagaagaac attcatagtc 67080
agaaactgca ttagcatatt cttcaattag cttcattaaa aacatctgct tttcagtttt 67140
cattattcca cctaatcatt tcaagatatt gaactaactt agctttagat ttatccaaat 67200
cctttttagc tgttgctata ccttcgtatg aatatccttc gcaatgctca actgctaatt 67260
gatatgaatc tatttcaaca tcgcgtgcta atttaatgat tttttcaaac tgttcgtgtg 67320
ttagcatact taaactctcg tattatgatc gataatttca tcaagaaaca tatctaacgc 67380
ttctaaagca ttatcaactt tagcttcaaa gtctttaatg cctttatttg caatgcctga 67440
cgaaaaccaa gcaaagtcac taagttcctc atctgcttta cgaattaaag ctaccaattc 67500
cttaatttta tccgcttgtt cgatactaat cattattcca ccacatatga aagagagaat 67560
attgcacatg ccatgtgagt tgcaacttca tcacacatat tataacgttt cttaagaagt 67620
tctacaagtt cttcactggt aacttcatcc atgtcgacga aaaaatcacc attaatgatg 67680
acgtagatat ttccttcttg attaagtgct tcaattttca tgatgttctc ctctttatcc 67740
gatggttgta tagtatcaca gctcaaacgg aaagtaaacc ggtaaaatga aaaagtctcc 67800
cgaaggagac taatgttatt cgagggaaag aagatactta ctctggtaaa acatcccagt 67860
aatatcatct atcgtgcttt gaatggctgg aggcatttct ttataaatgc tgttagattg 67920
gtctagtatg cgatcaatca ttttaattgt gtcggtagga agtttactgg catctggaat 67980
tgaaggcgtg tattttctac cagaataccc caaatattgc tcaccaaatt tatcaatcaa 68040
atctggcaat tcggagaaaa taaaatcgta tgctttgtgt ctagcataac ttttagtttc 68100
aaaatgcgca gaatgaaaat aagcttgtgc agccattaat aaacctaagt attcatctgc 68160
ctttgaaggt tttccacttt gtgaaaagtc gctgaatttc attcagtctc caatttaatg 68220
ttcataattc tagcgtatga ttgtgccatc tccgcgcctc gttctataca ttcaaaatca 68280
gaagagcacg ggtcattttt ataggtcgtt ctcataaaac tatagaactg ttcagatgat 68340
tctacgcttt tattttcaaa aagcatataa acatgtctaa taccagattc cataaattta 68400
tcaaaatgag gatcgacatt cgcttcaatt ggtggagata aagcaaatga caatcctagc 68460
atggcaaata gtgccgttgc ttttaaggcc ataaaggcct cctatcattt ttgtcctgta 68520
tttactttat gccgatgcac ggccttaact ttatcaaggt atttttcaaa atttcgcaat 68580
ctagtatagt ctgccggaga ttggttgagt gatacttctc gacgcaaagc tgaaatgata 68640
tttccaactt ccctacgaat ttcatctaat tgaagcacag taagattgcg aagttgcttt 68700
tcagttaatt gtagcatata taccccttta gttagataaa cctatttata acttttgcac 68760
taaccgagct ttttagttaa ttcattccaa tgttttctac acaaagaaac ataaatttca 68820
tcaccaatac agatttgatt accttcttta actggtgttc catcttccat taatcgagct 68880
gtcataatcg cttttttgcc gcaatgacaa actgccttta gttcaataag tttatctgca 68940
atcgctaaaa gttctttaga accttcaaac aattttccag cgaaatcagt ccttaatcca 69000
taagccataa caggaacatt atatgtatca acaattcgac ttaattgatg cacctgttca 69060
gtttttaaaa actgagcttc atctacaaat acgcaatgaa tatctttttg tgcttcagcc 69120
catttataga actcgaaaat atccatatca tctgtaataa tattcgcttc ctgtttaatt 69180
ccaatgcgag aaacaacttc acagacagaa tcgcgagtat caatagcagg cttaagaact 69240
aatacactca ttccacgttc tttataatta tgtgcagcag tcaaaagaga agcagatttt 69300
ccagcattca ttgctgcata agtaaaaatt aaactcgcca tatcaccttc ttaaagcgta 69360
ttcacataag ctattaattc attttctttc ttatcaaacc gatcagcaaa ttcttcctgc 69420
tgttcgggag atagcgggcc gtattcatca taaaaggtgt ttgcttctgt atgctcatct 69480
agaagttcat ggataagctc aaacaattta tctttttgtt ctttgcttag actcacagta 69540
tgtcaatccc caaaagtttt aaaatgactc gtttctgatt cataaccgct acgattgaat 69600
gaccgttgtg gtctttttga cctgatccaa ttataaatcc tttttgcgca gaaagttcaa 69660
tcaaaacatc aagttcacgt aataattgat attttaaatc atcattcatt ttggtttacc 69720
ttctttaacg aaatcaggat aaggataaaa tcccgaataa aatccttcac ctttatgatt 69780
gatgcatcct ttattagaac aatagcacca ataatcgaaa tcacaagcca tttcatcgtt 69840
gcataaagca aaaacaaccg gccacttaca cttttcacag tgggcatttt taagaatact 69900
agtttggctc ataaccatgt aacctttaag caatattctt ctacatgttg tttacgacct 69960
ttcttatcaa taaaggtata ttcaacgaat gttccaatgt agtctttatc tacatcatgt 70020
ggactattaa ttggacattt agtacggcaa atgcgttccc attgacgaat aatttccact 70080
ttgtttttag gatcaaacgg atgtgggtaa tgtactttca taatccacca ctattaaatc 70140
aatatcagga gtaaacatgt cgattaattt agaaacctta tcccaatcgc cgccagcaat 70200
accacaacct atgcgtggaa tgtaaattac tggtttaaac aaaagggttt ctgcctgtag 70260
atttaattct atcatgcagt ttactaaagc accataatca agattaggac ctggttcgta 70320
ttgcgtgtac aagttataac atatgccaaa accattaggt ttatgtttaa aaacaataga 70380
catatcgcct aatttatcac gagaaccgta ctcagtagtg gttttatcta tttctaaaat 70440
tttgggatag gctcttgcta attgacccgc tacacctgaa cccatagtat gaaaacaatt 70500
gcacccgtgc gcaataatat taccttgaag aaatagggcg acaatatcgc ccttgatata 70560
ttttacaatc atctagtact caatcctcga ttataagaat ctaccaaacg gtcaaccatt 70620
gaatgacaag cggctttatc tttctcctcc gcaactgaac attctaaggt attccacttt 70680
ttagcatatc gttttaacaa tgtatcgttt ttgtatctgc ttgatttatc tctttctccg 70740
tctttatatg catatattaa tttctgcgca aattcagctt ggcatgcttt atttttcccg 70800
caataatccg ctgcagtacg gtttacatac tctctaattt cagtatatga tgtatctgct 70860
aacgcagaaa atgaaattaa tcctatacat aaaaccaaaa ttttagtcat ttactatttc 70920
caaaagttta ttatttttaa ggtaattagc cttttctagg acttcagaag catatttaga 70980
acctgcttta acattccatc ccgaattata agaggatatt gcttttctta tatcgccctt 71040
atgtatattt aaccaataag aaagttcaat gtacgcccag gaagctgaat tggaccgttt 71100
attcaacatt ctttttattt cagcatcggt catattataa ccaagttcct taactcttgc 71160
tcgcatagta ggcaaataat tttggaacat tccataagcg tgatgctttg gtttagattt 71220
taaattaact ccgccagagc tttcttgcca taaaatagca gccattatat gacctaatcc 71280
gctcttgtgg atatttttgt gtgttttata ttttccatcc ttagaaaatt gttccccgaa 71340
ttgatacgcg taacgcatgt tatcgagttg gacattactg aaagtatgct cggagctatg 71400
tgccatcatt gaaatggcca atagaccagc gagtagtgct tttctcatgc ttacctcatt 71460
gagttttaat tactgcttta gaagcctttc ctggtaaacg acgactgttg ataattgcca 71520
tcctacattg aagtgacggg tctttgaact tcgcattagg tttacaaact gtaaatccaa 71580
gccaaagatt tccatctgtg atttctaaac gtccaggacg atattcaacc ccatcaataa 71640
aatcctcgtc aatgtcagga cgcggaggca tactcaggaa ttcattaact tctaaaacat 71700
ggtcttttat tttatggaat aattcaaaaa catatgtctc atcaatctcc cgttgaattg 71760
cacgatcaag aagatgttga gaatatttta gatgaaacga tgagactcct gctgcttttg 71820
atgcctcacg aatctcattg ttaatttgac gaaactccga ctcaaagtga cgacgaagct 71880
tatttcgacg gataaaaact tctgtattga tagtcatgtt attctcctct taactgatag 71940
aaaaattata ccacagtcaa gaggaaaagt aaacagttat tctttaaatc taatcaattt 72000
attcatagac tttgaaacct ctgcacgaac ctcatgtaga tttttgagct gttcaagacg 72060
ctgctcatag taagcaattt catcttcttc gagacagtcc tgtgaatctt ctttaagata 72120
acgtgcatag tcctggaaag cgttacgaac tacttcctgg aagtcatcaa gactttgaat 72180
tttcttagga gcagcagata cacgacgagg ggcagtataa tactcataac caaaccctgc 72240
gcttaattga gccattagta tttttcctct ggttggaaca ctgcgcgaca agcccacata 72300
ctggcttctt tgagtttcgt tttagcaata gttaactgat cgaggctttc ggcgtaattc 72360
ttcgcgagtt catcatcttc acagctatca aatgcttccc aaaattcatc gtataaagca 72420
tcaaagataa gtcctaaacg aacttcagcg tctttaatag catttacttt accgattttt 72480
tcgtcggtgt gtggcttata acctttaata tcttcaatca tatttgactt cctcaccagt 72540
gcataaatca tattcaacta aacgaatagg ttcatgaatg ccatatccct gaacagaaat 72600
ttctgtcgta ggataaattc cattaatatc acccatgttc catgcttcgt taaattgctg 72660
ttcgcctgaa ttactaaacc actcggcgaa agcatttagc acatcttcag aaccttcaat 72720
aattatcttt gccattacaa actctcggtg aaggtacgag cgataacgtc gcgctgctgt 72780
tccggagtca gagagttaaa gcgaactgca taaccggata cacggatggt cagctgcgga 72840
tatttttccg gatgcttaac tgcatcttcc agagtttcac gacgcagaac gttaacgttc 72900
aggtgttgac caccttcaat tttaactgta ggttgtgttt caatttcaat ttcacgggca 72960
tgcaaaccat agaaaatttc tgggtctaca aaagagtcct ctttaaaggt tttagaaaca 73020
ataattcgcg cttgaatacc atcttcaaaa taaatagtac ctttatgcgt gccttcaaga 73080
atttgatatg ctttcatata acctctcaat tagaaaataa atttatccaa gattgttctt 73140
taattaaaaa tggctcagaa tcgtatgcca ttaaactttg ggtgattagt cctttaaaag 73200
gtccatcaat aaattccata gtaaaatatg gaattttatt cattaatctt gcattaggag 73260
cagtacacaa aactctgcat cctttgaata cgcctttttg taatttgtat tgcttgggat 73320
aaaattcgct caaaatgtta ttttttgcca aaatttcaaa atgattcacc aatttatttt 73380
taatagtttt tggcgaaaaa taaagatatt cgaaaagttg cgtatctgtc atcattgcat 73440
tccgattacg aaaaactgtg gacgagtaat accaccaatg caacatttaa tattacagca 73500
gcagtgtaca gtgtcaatat ggacactata aatcttatcc atatcaggag atttgacagg 73560
ctcatcaatt atatacaaaa ttcgcgaaag cgataaacct ctgaacttgc ttcctttatt 73620
accaataaaa ctgcgcacag aatcagtaaa taaacgaaaa cgtatatcat cattagaata 73680
acgcgaaaat tcctttttaa tattatctgc ggaaatttta gcgtaagctg aagtattaga 73740
aagaacaata actgttccgc catcatacag ccaattagca gcaaagttag tcacagcaat 73800
tgatttgccg gattgacgtc caccatctat acgaagtgtg cagtactgtt taagtaattc 73860
ttcaaatggc gggatataat cgtttttaca aatttcttct actctagcat cagaatggtg 73920
tgtaaaagca ttcatcaggg atagataagg accagttaaa aatgttctca ttttattctc 73980
tctaggtttg ggccattccg tggcacatga attgtccatt tctgtattta cccattaccg 74040
cacttgggct cgaccttatt acaggttggc gggaatccct catagaatca tgaggtccag 74100
cttgttccca tatttcttat ttgcttattt aaatgatttg acgtactgaa cagaaccttt 74160
actattcacg aaagcgattt taccattttt attatacatg gtagcagtac gctgatagcc 74220
ataagtttgc ttaccagatt gataaccaac taatgcaaaa ttatcttcac ccattttatt 74280
ctgtttagcg cgaatgcgtt catgaccatg tgccataaga accttagcat cacccgttgc 74340
aatggatcta cgagtttttt catcttcaac tgtattaaca aaatcatcaa atgaatcaaa 74400
tttagcatga gatttattat acagttttcc atctactgca taattatatc cttgcacatc 74460
catctcaact tctgtaccat catccaatac agcagtgatt ttctgtcctt ttttaaattt 74520
caaaagatca gtaaaagatt cagcaataat ttgagaatta atagctgctt cagtgataaa 74580
ttcttgatat gttttcatat gtttccttta aatgtaaata tttttgccgt aatacttgta 74640
ccagtgtggc ttcattaaaa ttttttcatc gagtcgttgt tgactcaatt taatagctga 74700
tttgcatgga ttataatcat ttttccattc tgctggaata tcgctgatgt caggaacttc 74760
agtatctttt atactaaacc cgcgttttaa gcattccgtt ataatgtctg attgacgctt 74820
tcgcaaaaat tctaacttat cgtaaaagaa cgtaacatga ccagaaccta aaataaactc 74880
ggaagatatt ttaaaatctt taacccgctt accatttgcc acatgtttac gaactatacc 74940
aaaaacacgt ggcaattcac ggtattctgc gattaaatgc tgatcagcaa gttcagatac 75000
taaagtcaaa ttaatacgag tcattttatc cctccaagta actgtgaata tactatcaca 75060
gttctaggag aaagtaaaca actttataga tttttatacg cgtcccacgt accagttcta 75120
aacgtggcaa tgactcgttt tgcgcgatta ggtgtttgat tataccatct gcttttagct 75180
aagttaactg ctgcttcatc ccagcgtttt tgctggagca ttcgtaaaga attagtgaat 75240
ccagctacgc cagtttctcc catttggaaa accatattaa tcaatgcgca gcgccgaaca 75300
gcatcaagag aatcataaac tggttttaat ttagcatttc tcagaattcc gcgaacagcg 75360
gcatcaacat cctgattaaa gagtttttca gcctcgtctt tggtaattac accattgcaa 75420
ttacgcccaa tagctttatc taattcagat ttagcaacac taagcgatgg acttttagta 75480
agtaaatgac caatgccaat agtgtaatag ccttctgtgt ctttatagat tttaagtcta 75540
agaccttcat ctatacgtaa catttcaaat atattcataa tacctcctaa gtatttatag 75600
aaggtattta taaattaaaa gaggttgttc attattcggt aaagtgaagg acccatcaca 75660
tattgccact gagtacgagg aataagagca aaagcgtcca tctctggaat cataacacca 75720
tctttatttt caaaataaga ctcacaatgg caatttctaa acatctcatg ctctactgga 75780
atcgtataat aaaataactg taagtcttta ttactagaat atttaaatac acctaggtct 75840
tctagaaggt ctggattata attgctaaaa ccggtctctt ctaagcattc tctttttgca 75900
gcttccagtg cattcaaatc agaactttct acacgacctt ttggaatatc ccaacgatgt 75960
gccatcattc caggcttacg agaaccagta acccgaccca taaataaatc tttatcttct 76020
gtcatgaaga taataccagc tgataatgtt ttcattttaa tttcctgcat tcagtgataa 76080
agctatttaa attttgagca tatttctttt catcataaat cttttgctgt ctgcgtaaac 76140
gccatggcat ttcaatgaac gtgtaccata tcccagataa tattgctgct gtaaaaatat 76200
taacaagtat ggttaaaata atccaatctc ccgttctgtc tactggactt tctccaaaga 76260
agcaaaatac aaatgatgtc acaggaaaac taataatgta ccacagaatc ataattttat 76320
ctgtgaacca atcagcgttc gttaatttag cgcgaccatt atgaatacac acgaatttat 76380
catctgttac agtagatggc ttaactgctt gatatcccat tctaaactcc ctaattaatc 76440
gtttctttgt atcttcagaa cagccgctcc agtcaactct atcgactgaa atgccatcgt 76500
ccccatcatc taaatcatac cagcgagttt ttaaaatcat ttgattttcc tacaatcatt 76560
cacgaattct ttcattgatt cattttcaat ataagacatg tagttattat attcttttaa 76620
ttgtattttg taatcctttt ttctttgcca atttatttta aaattatcat aatgaaaata 76680
taaaatgata ctaaagaatg aaaataatga aattgctata gtataatgaa gttcactcca 76740
aacttctatt atatttactg tgccgtcaat gtttaaaata atacagtcaa ttaacaatcc 76800
aaaaagacta cccgcaagag ctgcagccaa cgccacagca aaaattaaaa atgactcagg 76860
aagagaatat ttgactttat ttagttttgg cttttgcatc gtgattcctt aacaaatttc 76920
ataatttcat caaattcatg tgcagcaagt ttaagctgat gttccttttt aatcttttta 76980
cactgggctt tccaatcacg tacacgttta cgatagtgtc ttccttgata ccagtatccc 77040
acccaattta caggtactaa taaaaatgga actatcattg gaagaattag tgttgacgca 77100
aatattatat tagattcaat atcagtcata acatctataa ctattccaac ccccagtaga 77160
attacaaatg atacagctat tacaggacct attaatacat cagtagaaat tagctggcgc 77220
tttaattcat acttcaacgg tttacttgga agatacattg atggctttga catattctct 77280
acattccttc acaaattttt ctaataataa atcgctttca aaattgggat tttctacgaa 77340
tttatcaaaa agatcatcaa caatagttaa gatattcttt ttactaagaa tacgcttatt 77400
ttcatgcttc gtttcagaat caactataag agtaaagaaa tatttcttgc cctgaaattt 77460
tacagtagta tcaatataga ataaatttga cttttgtaaa ttacgtttaa accatgcatc 77520
acttaaacta taaacgccaa gataatcata atcgtcgttt aaataacaga ccgtccattc 77580
aggagaaaca aaatcagtaa attcaacgtc aaaatcgcat gttaatgaat gaattgattc 77640
aatactgtta ataagtattc caggacgtat taaagacttt ttacctctag aaaatcttcc 77700
agaaagattt tcatcagttt catatgaaga accccaataa taattacgtc cttctgccat 77760
acgtttaaga gcatttaata attggtctgg aacatcaact tgtctttgga attcttcaaa 77820
cattgaattg aaatcacttt gcatttttca ttcctattta ctccaagtaa taggggccga 77880
agccccttat cattatttca gagaattaat atattcctga acatcggcag aggtagtttc 77940
aaccccagaa atattgccat taaaggtttc aactcgggca agagtatctt caatatcaac 78000
cttagtcagc gctgcaattt caactacatc atcagcagta ctaattccga gggcattcgc 78060
ggcgcgagtt tcacggatat attccaattt aactgcaagt tcttggcgag catcatctaa 78120
ctcaactact ttcttggcga tttcaattcg catttcagca taaccatcag ctttagtagt 78180
cagctgctca gctgttcgac gatatagtaa accgagttta gcatgcattg ttacatcttg 78240
accttcagaa aggagcttgc gaatttcgcg ctcttttgat tcggcctgct tattcttttc 78300
gacaataagt tcacgaatac gcttttcttc gttaatagat ttaatggaag cagtttttag 78360
gtctttaatc ttatcaagta gttttgctgc tgcagcagta tactgttctt caacagatag 78420
atttttagcc ataacagaac caagtttagt gcgaataaac tcaacaattt tcttcagtgt 78480
gttcatagta tttccttagg ttgattaaaa ttaaaatcca cagaaaaatt atatcatgct 78540
atttaagaga tgtaaactat ttttaatttt acaaattcgt tcagcttctt caacagcggc 78600
agtgataatg cttttagcta taggagtact aatactagta gcttttacac ttaacacgat 78660
ttctttatct ttaccaggcc aaccccacga tttttcacca tgagtgcctt taattacagc 78720
agacacctca agtgagcatc cattatcaca tgtttttaca ttaacaaccc aagtgtcact 78780
tttctcaacc ggtttatccc agtaaatatt gagaatacgc gggacatcaa atttagcagg 78840
gcaaatctta accgtaagac cttcgctttc tagccaatta ataagaggac gttcatacat 78900
gcggcgatgt gggctttgaa ctcgacaagc cttgtaccca ttgcttgcgg cttcactaag 78960
ctcttctaat acctgctttt gcattattga taagatacca tcaaaagatt tttcggaagt 79020
ttcattcagt tcggtataaa gagacataac agttttcctc aaattatagg ctcataatat 79080
ctcaatcatg agcctatgta aacttatttc atattattga aatattcttc tgcaatttcg 79140
tcgttatcat gataaacttt agaagacagt ttaacataac cttcagcagt gaacatgtta 79200
atcacaacct ttacagtata ccactgacca tcttcattac ccattactgc gtaagtttca 79260
aacatcggat gatcaggacc gataacttta atatcattca ctgtacgacc aaaatcttct 79320
gaaacacatt tcataaagaa gttgaacagt tcgccgtaat tatccatttc attctccaag 79380
ttgttttctg tatcagtagt tgatagttgt atagtaccat ggaagaacag ggatgtaaac 79440
agttttgtga aaaatttttt aaaaagtttt ggggaattct agggcaagga ggggaaatca 79500
aaggatagga taatatatta taaagggtag aaactaaatg atgcctagag aggcctggaa 79560
aggcctagat accaaaaagc cccaaccttt tggtcggggc taagaatgtt atttgatttg 79620
tttagcagac caaatgcggt ctttaataat tttttggatg tcttcaacat actctaggtc 79680
atgagcatgt gggttatctt taaagctatg agcacgagct agcttttggc cttcagtttt 79740
gattactaaa agctctttaa ggatagcttc atatttggag ataattcctt taacgatatt 79800
tttttttctt gtgcgacttt aggatctgct ttaggagcag gtttacccga agcctttgca 79860
aaagcagcgc cagtagcaac taaacttttc caggccatac taactgcatt tcccgtaaat 79920
ccttccgctt tcatgtcgcg tgcgaactga aatcgcgatt catcagaagc atctttgtaa 79980
gaatatttac ccgctgcaat ggctgctttt gcgacagctt gaatttcggt gctagatgct 80040
tcatttaaca ccgcttcatt taaaaattga gtatatgatt tcatcttatt tcctgtttta 80100
attcgtggat ttaatatact tatttatact aaaaagcccc aacctttcgg tcggggctaa 80160
gccttgcggc aaccttgtcg gggttccacc tgctaaggca agtgtttgta cgaaacgccg 80220
ggattcgaac ccggttatca agcagttgac gctactcaat atttttaaaa ggccatatct 80280
cgaccatatc cgaacgttcc gtcaaaaacg ctactcggtt tacggcaaag atatttcctc 80340
gaatcgataa ttcggtgcgc cgtttctgct gtgatagtaa agagccagaa cacagtaaaa 80400
ctgtgggagg aaactatact ccagggaaca tcagtccgac gacttaccgg tagcgacccg 80460
gtttcttagt attcttttaa agcatcaacc tgttcacgac gtttacgcca taaatcaatt 80520
acttcatacg cagattcagc atttcgaatt ggacggcatt tatataaaga cttgtgattt 80580
tgatattgtg tagataacgg aattttatct aaaaggtctt tacgttcaaa atattcgtaa 80640
ccatctaaac caaatgaacg atttttgaga aattgccaat gaccaaattc gttttcgaca 80700
taaacataat ctgcgtgttg ataaagcaaa ttagtttcac gagatgagat atggttttca 80760
tattcattga agtaaaatgt taaatcatga actactaagt aaacattacc tttcatattt 80820
tcctcactta taattggtcg aggcagtagg gatcgaacct acgacccagg acttagaagg 80880
tccttgctct tccttctgag ctatgcctcg tatttggcgg acgtgatagg attcgaacct 80940
ataaccaatc acttaacagg cgatcgctct gccattgagc tacacatcca aattggtggg 81000
gagtgatgga gtcgaaccac ccgagtcgca atgacaatgg atttacagtc cacaccgcta 81060
cctctacggg ataactcccc aaattaattt ggtggccctg ggtggaattg aaccaccatc 81120
tggcgattat gagtcgcttg cttgaacctt ccagctacag ggccttggtg ctgattgacg 81180
gaatcgaacc gccgaccttc tcattacaag tgagttgctc tacctactga gctaaatcag 81240
caaaactggc ggaggcgata ggatttgaac ctatgagtcg ccggagcgac tgccggtttt 81300
caagaccggt gcattaaacc actctgccac gcctccagtc tccgcggcag gatttgaacc 81360
tacgacattc tgctcccaaa gcagacgctc taccaaactg agctacacgg agtaaattaa 81420
attggagcgg ataatgagaa tcgaactcac atcatcagat tggaagtctg aggtaatgcc 81480
attatacgat atccgcaaat ttggtgcgag aagtgggact cgaacccaca aggaaatcat 81540
tccgcagcat tttaagtgct gtgcctttac caatttgacc attctcgcgc tgggaataaa 81600
ggactcgaac ctttgcatcc tggaatcaaa atccagtgcc ttaccaactt ggctaattcc 81660
caattattaa caaaggctct ctaacaagaa cccttgatga tagagggtat taatcagtgc 81720
ggtatgagtt aataataaca aataattctt aaagcatatt taccatttat gataatacat 81780
atttacgatg cattcaagac ccaaaggatt cttgaaaata tcatattcaa gaggaccttt 81840
ttctgtttca ataaagaaat caaaatttac tgtattaaat ttacggtctt ccttcactaa 81900
tttaacttgt gaagatgaac ggtcaatgta aaccttttca acttcaaaat atgttaaaat 81960
gccataatca tcaatcaagg ctttagccgc gtcttgatca tatttatatc cattttcaat 82020
ggatgatact ttcgcataaa gaatcattat caaccttcat caacaatagt gtgcgtattg 82080
gcatttacaa tttgccacca atcaaagcga ttagaaccat aatctagttt gttttcattt 82140
tctttgataa tgtcacggag ttcatcttcg gtagcggctt tcgctattaa atcagcatat 82200
ccaccacgag gataataatt atcacctgca aaaagtaaaa agtttggttt aatgttattg 82260
aactcttcaa gagtaataac ttttcctagt ggtagttgaa caatctctac atatttatat 82320
cctaattttt gagcagcatc tactgcttca agcaaagtat catgagccca tccaatttga 82380
caacctggct tttccgatgg attagcctga taatccgcat acactttgta cattctattc 82440
acctttagaa attttatcca taacgatagc aattaaacca attaaaaatg ctactacaag 82500
tgaaaacaca ttttctgctg tagtcaataa tccgcatata aatccaacaa acattgaaaa 82560
actaaaagcg gaagcagaaa ttgcaatagc aacatttcga attaattcac aacgtttcat 82620
tttattctcc tcagtagttg atagggtaat agtatcacaa ctaaaaccct atgtaaacaa 82680
ctttgtgaaa aatttattac aaaagatttt tagcaataat tttaagctga gctactgaaa 82740
tatgcttggc tttaaacaaa gcagtttctt cagcaggtga gataacgatt gtagcaccat 82800
ctttcttagc ggaccatcca tcacccaggt aaacagtacc tttgacttct tcgccatcaa 82860
ccaggctaat catcggttta ccttcacgtc ctttgtttgc tttaataact tcagaagtaa 82920
gggtcgcttc agtcaaagta gaagcgttag tcgttgaagt gaattcttga taagttttca 82980
ttttattttc ctaaattaat aaatgtgttg atggagataa tatcacttct ccatcatcgt 83040
gtaaacaact ttgtgaaatt attttaaatc atctgccaat caagcttaag aggttctttg 83100
tattcacgat ctaatacgac cggaatttgt acatcaccgc taaatgataa gggcccaaca 83160
ttataagaca atgttatatg cggtgtgtaa tcgtcaaaat catgtgtagc acctagcgcc 83220
cgcgcataca tgtgccgaca gcgcagatat tcagaatcta gtacaagtac aagagtagat 83280
ccatcttgtg ttttccatac ttctaaatgt ccagaagaag ctacttcaaa acttccgctt 83340
gatggaacat acggaacatt tactcttgaa taacatatag tcgaatgaat tttttctcta 83400
ggaactggat taggaacacg taaagagcgc tggagttctt ccagcgcatc aagtgttaat 83460
tctgaaaact tagctgctac ataaagaccc gttgaaaagt ctttaaattc cattattctt 83520
catctgcaga ttcagcagta agattcttga cagcttcaac gatttcttca actttaatag 83580
tatcgccggt aatacctact gcgcgagcaa tttcagccaa agttccttgc agaattttag 83640
attcttccat cagacgagcc gcttggtcct gcgtatcaag aatgcgagat ttcagagtta 83700
cgatttcagc agatagtttt tgttcaatag tttgttcaga cattatagta cctttagtgt 83760
atttttaatt ttagaaaaaa gttcttcaag agaaccatcg tttgtaatta ctaaatcacc 83820
atcacgaatt ggcaatccag cttctgtaat atgtgtatca ttggattttt gaccaggacg 83880
aactacatga attactgtag cacccatcgc cctagccgca tccatttcat gatcttgacg 83940
ggtatcagga acgatataat aatcataacc tgagttaaat ttatcaagat aatctaaagc 84000
aaataatttt acccagtaca tgcggtcgaa gttattaaca atcaaatccg tacctagggc 84060
ttgcatcaga cgacggactg accattgatc ttcaatatta tttataacgt caataatctt 84120
gttaaatgct acggaattaa ctgattcttg tccttcgtca tcaaaaacaa acacaccctt 84180
aattgggctt ttaccattaa gatagcaaaa tgcttgttcc ataatcgtaa ttacttctaa 84240
tttagtcaga tttaaattag tttcacgatc atagtcaatt ccttcaaact ctttacgagt 84300
taaacaagga tagtcagtgt ttgctgcaaa tacaccccat gcataagcca atgcatcctt 84360
aataggacca gcaagttggt atttaactgc agaataattg ctcatgataa aatcagcagt 84420
agtatctttt ccactacgct ttacaccgct taaaaagatt agtttcatgt gtttctcctc 84480
aaatttaatt aagattataa cacacaaaac tgaagcatta aacttccgct ataatttttc 84540
catctttttc tacttgaaaa taggtgtaag gaatcgttgc agtacatact aaagccgggt 84600
ctgaatcttc tgtgtagcta aattctactt cagataggtc agaaacccaa ggcttataaa 84660
aatttattga catcacgatt tcagttttgc tattatctaa gatgtaaagc gtaatgtact 84720
caggacctgt tttttgggca gtattttcac ctgtaagata gttgctagtt cctaacatcc 84780
attcatacat tcctatccac gacttaagtt cttcatcaac tataaatctc acaatgagtg 84840
gatcatactc aaatgtaaca cctggacgtt gtgctcggcc cagtccaaac ggcccagtca 84900
cggtatcagt aacaggtatc ctaattcccg gaataggaac tgactgagca tttaaagtaa 84960
aagcagatgt agtattacta tgcggtattg atactacaaa gttagttgta tttgcttggt 85020
taaaaatttg ttgtagtgct tgcgacatat attcctcata atgcttcata aatgttggtg 85080
gtataatggg tctaagtccc ttccattcaa ttccaattag aacaaacaac agaaaagaat 85140
ggaagataat agaattagat atttgaccag actttgtttg cagagaaacg ttttcctttt 85200
gaaacgaact gctgaagtgg catcaacaca acgttcgccc agtctttcgg ggcgatttca 85260
acgaggctac ccataatatt accgggtata tatgccttaa tcatttgatc tgcaccccta 85320
aatcctttca cttgactcca atcaattttt aatttcgttt tattagtaat agtaggtgta 85380
tttgaatatt gctttaaaag ctcttctaga aattgctgac gagctttagg tggaatatag 85440
tgcaagttca atccgtacat taaattatgc ttacctaaac caaggtaaat tatcaaagga 85500
aatttatccc agtaaggaag agtttccttg tgtttagcat cataagcaaa agcatatatt 85560
cgtcccggct gcgggcgaac aactttatgt ccttttactt gcttaatagt ttcagcaaac 85620
cattttctgg ttttattatt aattgctgca ccttcattac gaattttatc gcgcaatgtt 85680
tgtctgaatg aatttatcat aagcagttgt ctttcttgct tattgagttt attcattggt 85740
tttgattcaa gcttttgaat cttttcagct gttttaattc ctgaagcata ttttgacatt 85800
gccgaagtaa acgtagagta tttgattcct ctttcttcag caaattgctt tcctgtcatt 85860
ccttttgctt tggccttttt gtattcaaga cctatctgaa tccatttctt ttcgtttaat 85920
gattgcttaa cctttggaac ttggggagta ctttcattaa ttatttgaaa aatagccatt 85980
atgccccctt aaagccaaga gctcgtaatc catcttctgt tagaattcta aattttattc 86040
cacgcttttc agctaaagct tgcgctgctt tccatttgtc agtattaacg gaatatgtat 86100
aaatttcatt cataaatctt ttcttcgctg cagttgttag atgtgctggt ttaactggtg 86160
gttgtgtttc ttttttaggt tttatttcaa taaaaaattc ttgcccagaa gaatctttca 86220
tccaaatatc catgaagtat ctacgttttt tcccttctgc attacaaaaa taaggaatta 86280
ctgctgtttc actaccccat gcaataattt ctggattttt atctaaccat tcaaaaaaga 86340
atttttccca atttgatcta tacgtaattt ttttagggtc acctctatat tttgatatat 86400
ttttaggaac ccattttcca gaatatgcca ttggattctc cttataaata gataatatat 86460
ttataaacag gagggcccat gctctttaca ttttttgatc cgattgaata tgcggccaaa 86520
acggtgaata aaaacgcgcc gactattcct atgacagata tttttagaaa ctataaagac 86580
tatttcaaac gcgctcttgc gggatatcgc ttacgcactt actatatcaa aggttcacca 86640
cgcccggaag aattagcaaa tgctatatat ggaaatccac agctgtattg ggttttattg 86700
atgtgtaatg ataattatga tccatattat ggatggatta cttcgcaaga agctgcttat 86760
caagcatcta tacaaaaata caaaaacgta ggtggagacc aaatagtata tcatgtgaat 86820
gagaacggtg aaaaatttta caatttaata tcatacgatg ataatccata tgtttggtat 86880
gataaaggcg ataaagctag aaaatatcct caatatgaag gagcgcttgc tgcggtcgat 86940
acgtatgaag cggctgttct tgaaaatgaa aaacttcgtc aaataaaaat aatagcaaaa 87000
tcagacatca attcatttat gaacgacctt atacgtataa tggagaaatc ttatggaaat 87060
gataagtaat aaccttaatt ggtttgttgg tgttgttgaa gatagaatgg acccattaaa 87120
attaggtcgt gttcgtgttc gtgtggttgg tctgcatcca cctcaaagag cacaaggcga 87180
tgtaatgggt attccaactg aaaaattacc atggatgtca gttattcaac ctataacttc 87240
tgcagcaatg tctggaattg gaggttctgt tactggaccg gtagaaggaa ctagagttta 87300
tggtcatttt ttagacaaat ggaaaactaa cggaattgtc cttggcacgt atggtggaat 87360
agttcgcgaa aaaccgaata gacttgaagg attttctgac ccaactgggc aatatcctag 87420
acgtttagga aatgatacta atgtattaaa ccaaggcgga gaagtaggat atgattcgtc 87480
ttctaacatt atccaagata gtaacttaga cactgcaata aatcccgatg atagaccact 87540
atcagagatt ccaaccgatg ataatccaaa tatgtcaatg gctgacatgc ttcgccgtga 87600
tgaaggatta agactaaaag tttattggga tactgaagga tatccgacaa ttggtattgg 87660
tcatcttatc atgaagcagc cagttcgtga tatggctcaa attaataaag ttttatcaaa 87720
acaagttggt cgtgaaatta ctggaaaccc aggttctatt acgatggaag aggcgacgac 87780
tttatttgaa cgtgatttgg ctgatatgca acgggacatt aaatcacatt ctaaagtagg 87840
accagtctgg caagctgtca accgttctcg tcaaatggcg ttagaaaata tggcatttca 87900
aatgggtgtt ggcggtgtag ctaaatttaa cacaatgtta actgctatgt tagccggaga 87960
ttgggaaaaa gcatataaag ccggtcgtga ttcattgtgg tatcaacaaa caaaaggccg 88020
tgcatcccgt gttaccatga ttattcttac ggggaatttg gaatcatatg gtgttgaagt 88080
gaaaacccca gctaggtctc tatcagcaat ggctgctact gtagctaaat cttctgaccc 88140
ggctgaccct cctattccaa atgactcgag aattttattc aaagaaccag tttcttcata 88200
taaaggtgaa tatccttatg tgcatacaat ggaaactgaa agcggacata ttcaggaatt 88260
tgatgatact cctggacaag aacgatacag attagttcat ccgactggaa cttatgaaga 88320
agtatcaccg tcaggaagaa gaacaagaaa aactgtcgat aatttgtatg atataaccaa 88380
cgctgatggt aattttttgg tagccggtga taaaaagact aacgtcggtg gatcagaaat 88440
ttattacaac atggataatc gtcttcacca gatagatgga agcaatacaa tatttgtacg 88500
tggcgacgaa acgaaaactg ttgaaggaaa tggaactatc ctagttaaag gtaatgttac 88560
tattgtagtt gaaggtaatg ctgacattac agttaaagga gatgctacca ctttagttga 88620
aggaaatcaa actaacacag taaatggaaa tctttcttgg aaagttgctg ggacagttga 88680
ttgggacgtt ggtggtgatt ggacagaaaa aatggcatct atgagttcta tttcatctgg 88740
tcaatacaca attgatggat cgaggattga cattggctaa tatacttcca atgagcgctg 88800
atttaggaga atccatggaa ggttcttcta tcgacgtcac ctttaccgct caattagaaa 88860
caggtgaaac gttagtatct ataaatataa ctagttacga agaaactcct ggggttttag 88920
tagaagaaaa tcgcttatac ggaacatatg aatctgtgtt tggatttgga aatgacgcgt 88980
tgaaatatcg tttaggcgat gaatttaaaa ctgctgcttc atgggaagaa cttcctactg 89040
attctgatac tcagttgtat ttatggaaag ctcctcaaaa cctccagaag acattcactt 89100
acgaagtaac attaatatat gactaccaag aacaaagtga atctggaggt tctggcagta 89160
attctaggtc atcttctgat actactgaac cgacagatcc tcctgctcca gtaagaaaaa 89220
ctctcgttaa aaattatact aaaactatag ttggaaattg gagtcgttgg gctaataaat 89280
taagaagcta tgtgtatgag aggtcataga tgtcaggatt aagttatgat aagtgtgtta 89340
ctgccggcca tgaagcatgg cctccaacag ttgtgaatgc tacacaaagt aaagtattca 89400
ctggaggaat tgctgttctc gtagcaggtg atccaattac agaacataca gaaattaaaa 89460
agccatatga aacacatggc ggagtgacac aacctagaac ttctaaggta tatgtcactg 89520
gaaagaaagc ggttcaaatg gctgatcaaa tatcatgcgg tgatactgtg gctcaggcat 89580
catctaaagt attcattaaa taggatttaa aatggcaaat acccctgtaa attatcaatt 89640
aacaagaaca gcaaatgcta ttcccgagat attcgtcggg ggtacgtttg ctgaaataaa 89700
acaaaacctc attgaatggc ttaatggcca aaatgaattt ttggattatg attttgaagg 89760
ctcaagatta aacgttctgt gtgacctttt agcttataat acattgtaca ttcaacagtt 89820
tggtaatgct gctgtgtatg aaagctttat gcgtactgct aacttacgaa gttcagttgt 89880
tcaagctgca caagataacg gatatttacc tacttcaaaa tccgctgcgc agaccgaaat 89940
tatgttaaca tgcaccgacg cattgaatag gaattacatt actattcctc gcggaactcg 90000
ctttttagca tatgcaaaag atacttctgt taatccatat aacttcgttt ctaccgaaga 90060
cgttattgct attcgtgata aaaataacca atattttccg cgtttaaaat tggcccaggg 90120
acgtatagta agaactgaaa tcatttatga taaattaaca cctattatca tttatgataa 90180
aaatattgat agaaaccagg ttaaattata cgttgatgga gcagaatgga ttaactggac 90240
aagaaagtca atggttcatg ctggttctac atcaacaatt tactacatgc gtgaaactat 90300
tgatggaaat actgaattct attttggtga aggtgaaatt tctgttaatg cttctgaagg 90360
agctttgacc gctaattata tcggaggtct taaacctact cagaactcta cgattgttat 90420
tgagtacatc agtactaatg gtgctgacgc gaacggagca gtcggatttt catacgcaga 90480
tacattaaca aatataactg tcatcaatat taatgaaaat ccaaacgatg acccagattt 90540
tgttggggca gatggcggcg gtgatccaga agatattgag cgtattcgcg aattgggtac 90600
tattaaacgc gaaacccagc aacgctgcgt aactgcaacc gactatgata cattcgtctc 90660
agaaagattc ggttctatta ttcaagcggt tcagactttc actgattcta ctaaacctgg 90720
ttatgcattt attgctgcta aacctaaatc aggactatat ttaactactg tacaacgtga 90780
agatattaaa aattatctca aagattataa tttagctcct attacaccat caattatttc 90840
tcctaattat ctttttgtta agactaattt aaaagtcaca tatgctttaa ataagctgca 90900
agaatcagaa cagtggctag aaggtcaaat aattgataaa attgatcgtt attataccga 90960
agacgtagaa atttttaatt catctttcgc taaatctaag atgttgacat atgtagatga 91020
tgcagatcat tctattattg gctcatcggc gacaattcag atggtacgtg aagtacaaaa 91080
cttctataaa acgcctgaag cgggtattaa atacaataat caaataaaag atcgttctat 91140
ggaatctaat acgttttcat ttaattctgg acgaaaggtt gtaaatcctg atactggttt 91200
agaagaagat gtattatatg acgttcgtat agtatcaaca gaccgagatt ctaaaggaat 91260
tggtaaagtt attattggtc catttgcttc tggcgatgtt acagaaaatg aaaacattca 91320
gccgtataca ggcaacgatt ttaataaatt agcaaattct gatggacgcg acaaatacta 91380
tgctatcggt gaaataaatt atccagctga catgatttat tggaatatcg ctaaaattaa 91440
tttaacatcc gataaatttg aggttcagac tattgagcta tattctgatc caatagacga 91500
tgttatcttt actcgcgatg gttcactgat tgtatttgaa aatgatttac gtccacaata 91560
cttaactatc gatttggagc ctatatcaca atgacagtaa aagcaccttc agtcactagt 91620
ctcagaattt ccaagttatc cgcaaatcag gtgcaagtac gctgggatga cgttggtgct 91680
aatttctact attttgtaga aatcgctgag acaaaaacaa actcgggaga aaatctcccg 91740
agtaatcaat atcgttggat taatttagga tatacagcaa ataatagttt cttttttgat 91800
gatgctgatc cactgacatc atatgttatt agagtagcta cagctgcgca agattttgag 91860
cagtctgatt ggatttatac cgaagagttt gaaacttttg ctacgaatgc ttacacattt 91920
caaaatatga ttgaaatgca attagctaat aaattcattc aggaaaagtt cactcttaat 91980
aattctaatt atgtcaattt caataatgac acaataatgg ctgcgttgat gaatgaatca 92040
tttcagttca gcccatcgta tgctgatgtt tcatcaataa gtaattttat tattggtgaa 92100
aatgagtatc atgaaataca aggttctatt caacaagtat gtaaggatat taaccgagtt 92160
tatttgatgg aatcagaagg gattctatat ctttttgagc gttatcaacc tgtagttaaa 92220
gtatctaatg ataaaggaca aacctggaaa gctgtgaagc tcttcaatga ccgtgtagga 92280
tatcctttat ctaagacagt atattaccaa tctgcgaaca caacatacgt tctaggatac 92340
gacaagattt tctacggccg taaatcaact gatgttagat ggtcagctga tgatgtcaga 92400
tttagttcac atgatataac atttgctaaa cttggcgacc aattacatct aggatttgat 92460
gtagaaattt ttgccactta cgcgacttta ccagcgaatg tataccgcat tgcagaagct 92520
attacttgca ccgatgatta catttacgtt gtcgccagag acaaagttag atacataaaa 92580
acgagtaatg cacctataga ttctgatcca ttatctccaa catattcgga aagacttttt 92640
gaacctgata ccatgactat aaccggaaat cctaaagcag tatgctataa aatggattct 92700
atcggtgata aagtttttgc tcttattatt ggtgaagttg aaacattaaa tgctaatcct 92760
agaacatcaa aaataattga ttccgctgat aaaggaatat atgttttaaa tcatggcacg 92820
aaaacatgga aaagagtttt tggcaacact gaagaagaaa gaagacgtat tcaacctgga 92880
tatgcgaata tgtcaactga tggtaaatta gtttctctat cttcgagtaa ttttaaattt 92940
ttaagtgata atattgttaa tgaccctgaa actgtggtga agtatcagtt aatcggtgct 93000
gttaaatatg aatttcctcg tgaatggcta gctgataagc attatcatat gatggcattt 93060
atagcagatg aaaaatctga ttgggaaact tttacacctc agccaatgaa atactacgca 93120
gagccgttct ttaactggtc taaaaaatct aacacacgct gttggataaa caactctgat 93180
agagctgtag tagtttatgc tgatttaaaa tacactaaag ttatagaaaa tattccggaa 93240
acatcaccag atagattagt tcatgaatac tgggatgatg gtgattgtac gatagtaatg 93300
ccaaatgtta aattcactgg atttaaaaaa tatgcgtctg ggatgctttt ctataaatcc 93360
tccggtgaaa taatttctta ctatgatttt aactatcgag tgagagacac ggttgaaata 93420
atttggaagc caactggaat atttttaaaa gcatttttac aaaaccaaga gcatgagact 93480
ccttggtcac cagaagaaga gcatggatta gctgatcccg atttaagacc attgattggc 93540
acaatgatgc ctgattctta tttgctacag gattcgaatt ttgaggcatt ttgcgaagca 93600
tatattcagt atctttctga tggatatgga actcagtata ataatttacg aaatttaatt 93660
cgtaaccaat atccgcgaga agagcacgcg tgggaatatt tgtggtcaga gatatataaa 93720
agaaacattt atttaaatgc tgataaacgt gatgctgttg caagattttt tgaatcacgt 93780
agctatgatt tttattctac taaaggaatt gaagcatcat acaaatttct ttttaaagtt 93840
ctttataatg aagaagttga aattgaaatt gaatctgggg ctggtactga atatgatata 93900
atcgttcaat ctgattcttt gactgaagac ttagtaggac aaacgattta tacagctaca 93960
ggaagatgta atgttactta tatagaaaga agctattcta atggtaaatt gcaatggacc 94020
gtaactattc ataatctttt gggaagatta attgccggtc aagaagttaa agcagaaaga 94080
ctccctagtt ttgaaggcga aattattcgt ggggttaaag gaaaggattt gcttcaaaat 94140
aatatagact atattaatag aagtcgatca tattatgtaa tgaaaattaa atccaactta 94200
ccttcttccc gctggaaatc tgacgttatt cgttttgttc atccagtagg atttggattt 94260
atagcaatta ctcttttaac tatgtttatt aatgttggtt taactcttaa acatacagag 94320
accataatta ataaatacaa aaactataaa tgggattctg gattgcctac tgaatatgct 94380
gatagagtag ctaaattaac tccgactggt gaaattgagc atgattcggt aacaggcgaa 94440
gcaatttatg agcctggccc aatggctggt gtagaatatc ctcttcctga tgactataat 94500
gctgaaaata acaattcaat atttcaaggt caattgccgt ctgaacgacg taaattaatg 94560
agtcctctat ttgacgcatc tggaacaaca tttgcgcaat ttagagattt agttaataaa 94620
cgtctaaaag ataatatagg aaatccaaga gaccctgaaa atccaacaca ggttaaaata 94680
gatgaatgat tcaagtgtta tctatcgtgc gatagttact tcaaaattta gaacagaaaa 94740
aatgttgaat ttttataatt caattggaag tggtccggat aaaaacacta tctttatcac 94800
atttggaaga tcagaaccgt ggtcatcaaa tgaaaatgag gtgggctttg ctccacctta 94860
tccaactgat tctgtattag gcgtaactga catgtggacg catatgatgg gaaccgtaaa 94920
ggttcttcca tctatgcttg atgcagttat tcctcgtaga gattggggag atactagata 94980
tccggatcca tatacattta gaattaacga tattgtagta tgtaactcag ctccttacaa 95040
tgctaccgaa tcaggcgcag gctggttagt atatcgctgt ttagatgttc ctgacacagg 95100
aatgtgttca attgagtctt taactaataa ggatgaatgc cttaagttag gtggaaaatg 95160
gactccttct gctaggtcaa tgactcctcc tgaaggtcga ggagacgcgg aaggaacaat 95220
cgaacctgga gacgggtatg tatgggaata tctttttgag attccgcctg atgtatctat 95280
aaatagatgt acgaatgaat atatcgtggt tccttggccc gaggaattaa aagaagaccc 95340
gactagatgg gggtatgaag ataacctcac ttggcagcaa gatgattttg ggttaattta 95400
tcgtgttaaa gctaatacaa ttcgttttaa agcatattta gattcagttt attttcctga 95460
agctgcattg ccgggaaata aaggatttag acaaatatcg ataattacaa atcctcttga 95520
agctaaagtt catccaaatg atccaaacgt taaagctgaa aaggattatt atgatcctga 95580
agatttaatg aggcattcgg gtgaaatgat ttatatggaa aataggccac ctattattat 95640
ggcaatggat cagacagaag aaatcaatat tctgtttaca ttttaaatta agggagccca 95700
tgggctccct ttttctttat aaatactata aactcataag gaaaccgcta tgttcattca 95760
agaaccaaag aaattgattg ataccggcga aattggtaac gcttctactg gtgatatctt 95820
attcgacggt ggtaataaaa ttaatagtga ttttaacgca atttataatg cgtttggcga 95880
tcaacgtaaa atggcagtag caaatggcac tggagctgat ggtcaaatta tccatgctac 95940
tggatattat caaaaacact ctatcgcgga gtacgcaact ccagtaaaag ttggcactag 96000
acatgatatt gatacttcta ccgtaggtgt taaagttatc attgaaagag gcgaacttgg 96060
cgactgcgtt gaatttatta actcgaatgg atcaatatca gttactaatc ctttaacgat 96120
tcaagctatt gattcaatta aaggcgtttc aggtaattta gtagtaacta gtccatatag 96180
taaagttact ttacgttgta tttcatctga taattctacg tcggtttgga attattctat 96240
tgaaagtatg tttgggcaaa aggaatcacc agctgaaggt acatggaata tttctacatc 96300
tggatcagtt gacattccac tatttcatcg tactgaatat aacatggcta aattgttagt 96360
tacatgccaa tcagtagatg gaagaaaaat taaaacagca gaaataaata ttcttgtaga 96420
tactgttaat tcaacggtca tttcttctga atatgctgtc atgcgggttg ggaatgaaac 96480
tgaagaagac gaaatcgcta atattgcatt tagtattaaa gaaaattatg taacggcgac 96540
tataagttct tcaactgtcg gtatgagagc agcagttaaa gttatcgcta cgcagaaaat 96600
cggggtggct caataatgaa acaaaatatt aatatcggta atgttgttga tgatggtacc 96660
ggtgactacc tgcgtaaagg tggtataaaa ataaatgaaa actttgatga actttattat 96720
gaacttggtg atggagatgt tccatattca gccggtgcct ggaaaactta taatgcttca 96780
tctggacaaa cactaacggc agaatgggga aaatcatatg ccattaacac ttcatctgga 96840
agagtaactc tacaacttcc taaaggaacc gttaatgatt ataataaagt aattaaagct 96900
agggatgtat ttgcaacatg gaatgttaat ccagttactc tagtagccgc ttctggtgat 96960
acaattaaag ggtcgtcatc gtcagttgaa attaatattc aatttagtga tttagagctc 97020
gtttattgcg ctccaggacg ctgggagtat gtcaaaaata agcaaattga taaaattatc 97080
agttcagaca ttagtaatgt agctcgtaaa gaatttttag tcgaagttca agggcaaaca 97140
gactttttag atgtttttaa tggaactagt tataatgtca ataacatcag agtaaaacat 97200
cgtggtaacg aattgtatta cggcgatgta tttagcgaaa acagtgactt tggctctccg 97260
ggcgaaaatg aaggcgaatt agttcctctt gatggattta atattcgatt aagacagcct 97320
tgtaatattg gtgacactgt tcaaattgaa acatttatgg atggtgtatc acaatggaga 97380
agttcatata caagacgcca aataaaagta ctggattcaa aactaacatc aaagacttct 97440
ttagaaggaa gcatttatgt tactgattta tcggcgatga aatcaattcc attctccgca 97500
tttggattaa ttccaggaga acctattaat cctaattctc ttgaagttcg ttttaatgga 97560
attttacaac aacaagctgg aacagccgga tatcctctgt ttttatgtga aggcgctaat 97620
tcagatacgc aagaaggatg tatatctctt ggtggcgaat ggaaagaatc aaacaccgat 97680
tattctatag aatatgaaga cggaaaacct atcagtcttt tatttgatag aaaatttgaa 97740
tccggtgaca ttatcgttat aacatggttc aataatgatt taggaactct tttagaaaaa 97800
gatgacatta ttgaattaac tgatgaccgt tatgttagta aaggatcatc tactgaagtt 97860
actggtgatg tagccttaac agattttgat aaaatcggtt ggccaaatgt tgaaaaagtt 97920
gattcttata ctagaacgta taattcaata tcatctattt tcgacagcat ttatcctgtt 97980
ggttcaattt atgaaaatgc tataaaccca aataatccgg tgacttatat gggatttggt 98040
tcatggaaat tatttggtaa aggacaagtt ttagtaggat ggaatgatga tgttacagat 98100
ccaaactttg cattaaacaa taatgattta gattctagcg gaaatccttc acataccgcc 98160
ggtggaacag ttggtacaac atcagtaacg cttgaaaacg caaatcttcc tgcaactaaa 98220
accgacgaaa gagttttaat tgaagacgaa aatggatcgg ttattattgg aggttgccaa 98280
tatgacccag atgaaactgg tcctatatat acaaaatacc gtgaagatta cgcaacaaca 98340
aactcttcac atactcctcc tgctaatatt agtaatattc aaccgtctat tactgtatac 98400
cgttggataa ggattgcata atgagtttac ttaataataa agcgggagtt atttcccgct 98460
tagcagattt tcttggtttt agaactaaga aaaatgatat ttcggttatg aataatcagc 98520
cagtaggtgc tgtaacaatt tcacaaatag caaaaggttt ttatgaccca aatgtagaat 98580
ctgctattaa tgatgttaga aatatggcag agcaacaggt tggagctgta ttagttaata 98640
taagcggcgt atctcctact ggagtgcaac aaacagacta ctggtcattt gaaggaactg 98700
tcaatgatac ttcagccaaa ccgggtgaca cagttattgt taacatgttt ggtattccag 98760
ttaaagctac taatggaatg acttcaatcg aatttaccag tgccgttaga acagctctac 98820
aggaaatggt tgcaaaattt attgcaattg attcatttga agaccatcct accataggaa 98880
ataaaataca agttaagtat ttagataacc aagaacatat cttagaacaa tactctgata 98940
aaggaattac tttcaaacaa gaaataattt ctccttctaa acctggatac ggaacttggc 99000
aattattagg tgcgcaaact gtcacgctag atagtcacac acaacctacg gtattttatt 99060
attttgagag aatagcatga gtaacaatac atatcagcac gtatcaaatg aatcaaaata 99120
tgttaaattc gatcctaccg gatcgaattt tcctgacact gtcacgacag tgcagtctgc 99180
attatcaaaa ataagtaata tcggcgtaaa tggtattcct gatgcaacta tggaagttaa 99240
aggaatagca atgattgcgt cagagcaaga ggttttagat ggaactaata attctaaaat 99300
cgttacaccc gctacattag caacaagatt attgtatcca aatgctactg aaactaagta 99360
tggtttaacg cgctattcaa caaatgaaga aacattagaa ggctcagata ataattcatc 99420
aataacgccg caaaaactga aataccatac tgacgatgtg ttccaaaata gatattcgtc 99480
tgagtcatca aacggggtta ttaaaatatc atctacacct gcagctttag ctggagttga 99540
tgatactacg gcaatgactc cattaaaaac gcaaaaactt gcaataaaat taatttcaca 99600
aatagctcct tccgaagata ctgcatcaga atctgtgaga ggtgtagttc aattatctac 99660
tgttgcgcaa actcgtcaag gaactctccg cgaaggatat gcaatttctc cgtatacctt 99720
tatgaattct gttgcaacac aagaatataa gggtgttata cgtttaggaa cacaatcgga 99780
aattaacagt aatttgggag atgttgctgt aacaggtgaa acattaaatg gtcgaggagc 99840
taccggttct atgcgtgggg tagtaaaatt aacgacgcaa gccggtattg cccctgaagg 99900
tgatagctct ggagcattag catggaacgc agatgtaatt aatactcgcg gtggacaaac 99960
tattaatggt tctttaaatt tagatcattt aacagcaaat ggaatttggt cacgcggcgg 100020
aatgtggaaa aatggcgatc aacctgttgc cactgaaaga tatgcgtccg aaagggttcc 100080
agttggaact attatgatgt ttgctggaga ttcagctcct cctggttgga ttatgtgcca 100140
tggtggaact gtgtcaggag atcaatatcc tgattataga aacacagttg gaacgagatt 100200
tggtggcgat tggaataatc ctggcattcc tgatatgcga ggtcttttcg tcagaggagc 100260
tggtactggt ggtcatattt taaatcaacg agggcaagat ggttacggga aggatagact 100320
tggtgtagga tgtgacggaa tgcatgttgg cggggttcaa gcacaacaga tgtcatacca 100380
taaacatgct ggcggttggg gagaatacca aagacatgaa gctccatttg gcgcgtccgt 100440
ttatcaagga tatcttggaa ctagaaaata tgccgactgg gataatgctt catacttcac 100500
taatgatgga tttgaattag gtggaccgag agatgccctt ggtacactta atcgtgaagg 100560
attaattggt tatgaaacta gaccatggaa tatatcatta aactatatta ttaaaattca 100620
ttactaagga ttacaaatga ttgaattaaa agatttacct tttgttgata gcgttcctgg 100680
cgaaggtcag gaacgtattt catggattaa aaatggtgaa gaaatactag gagctagtac 100740
taagtatgga aacgatggat caatgaatag accaactgtg tccgtattta aaaatgttga 100800
ggttcttgat gaaaatatag gaattcttaa aactgccgtt gaaacatcac aggaagatat 100860
taaaacaatt caaggcattt tggatgtatc tggagatatc gaagcactat cacagattag 100920
cgttaataaa aatgacatat caaatttaaa gacgcttacg aatgaacaca ctgatatatt 100980
aaatggtaca aatactacgg ttgataatat tctttctgat attggtccat ttaattcgca 101040
agcaaattca gtttatagaa cgattagaaa tgatttgtta tggattaaaa gggaattagg 101100
acaatatgct gggcaagata ttaatggtct tcctgttgta ggaaatagca gcacggggat 101160
gaagcaccgt atcattaata atacagatgc tataacttcc caaggaatac gtctaagtga 101220
tttggaagaa aaatttattg aatctgatgt aggttcactg acaattgaag tcggaaatct 101280
tagacaagaa cttggacaaa gaccatcttc atttagtgaa agcatatatt cacgtgtgca 101340
taatttagat caatcacaga ttaatcttag ttccgaaatt aaatctatca aaacttctat 101400
tggatatcca ggaaatactt caataatcac agatgtcaat gtcaacagtc aagaaatttc 101460
agctttaaat gatgaactaa ataaaagtgg cggcgttaaa cagcgattaa ctgttattga 101520
aacatcgatt ggttcagatg atattccttc tagtattaaa ggtcaaatta aagataatac 101580
cacttctatt gaatctttaa atggaattgt aggtgaaaac acctcgtccg gtttaagagc 101640
taacgtttca tggctaaatc agatagttgg aactgattct agcggaggtc aaccttctcc 101700
tccggggtct cttttaaata gagtttcaac tgttgaaacc tctgttaata gacttaacaa 101760
tgatgttcaa aacttacagg ttgaaattgg taataacaat tccggaatta aagggcaagt 101820
tgtaacacta aataaattag taaatggaac aaatccgaat ggttcaactg tcgaagaacg 101880
cggattgact aattcaataa aagctaatga gactaacatt tcttcaatta atcaagagat 101940
tcgtagtatt aaaggtaatg tgtcctcatt gcagagggat gtccagactt tacaagaagc 102000
tggttatatt cctgaagctc caaaagatgg tcaagcttac gttcgtaaag acggcgaatg 102060
ggtattgctt tctacctttt tatcaccagc ataacatggg gccgcaaggc cctaaaggat 102120
tttaaatgtc aggatataat tctcagaatc caaaggaact caaagatgtc attctaagac 102180
gtttaggggc tccaattatt aatgttgagt taacacccga tcaaatttat gattgcatcc 102240
agcgtgccct agaattatac ggtgaatacc attttgatgg acttaacaaa ggttttcatg 102300
tattttatgt aggagacgat gaagaaaagt ataagactgg agtatttgat ttaagaggtt 102360
ctaacgtatt tgcagtaact cgcattttgc gcacgaatat tggatcaata acgtcaatgg 102420
acggaaacgc tacatatcca tggtttactg actttctttt aggaatggct ggtattaatg 102480
gtggcatggg aacttcttgt aatagatttt atggaccaaa tgcctttgga gctgatttag 102540
gatattttac ccagcttact agttacatgg gaatgatgca agatatgctt tcgcctattc 102600
cagacttttg gtttaattca gcaaatgaac aactcaaagt catgggaaac ttccaaaaat 102660
atgatttgat tatcgtagaa agctggacta aatcatacat tgatacaaac aaaatggttg 102720
gaaatacagt aggatatgga acagtcggtc cacaagatag ctggtcatta tctgaacgat 102780
ataataatcc agaccgcaat ttagtaggcc gtgttgttgg tcaagatcca gatgttaagc 102840
aaggtgctta taataatcgt tgggtgaaag actatgcaac agctttagct aaagaactaa 102900
atggccaaat tttagcacgt caccaaggaa tgatgcttcc cggcggcgtt acaattgatg 102960
gtcaacgttt aatagaagaa gctcgtttag aaaaagaagc actgcgcgaa gaattatact 103020
tacttgaccc tccatttgga atttttgtag gttaatatgg ctacttacga taaaaatctc 103080
tttgctaaat tggaaaaccg cacaggttat tctcagacca atgaaacaga aatactaaat 103140
ccttatgtaa attttaacca ctatcaaaac agccaaatac tagctgatgt attagtagct 103200
gaaagcattc aaatgcgagg tgtagaatgc tattatgttc caagagagta tgtttcccct 103260
gatttggtat tcggcgaaga cctaaaaaat aaatttacta aagcatggaa atttgctgca 103320
tatttaaatt catttgaagg atatgaagga gctaaatcgt tctttggtaa ctttggtatg 103380
caagtacagg atgaagtaac tttgtccatt aatccaaacc tgtttaaaca tcaagtaaat 103440
ggaaaagaac ccaaggaagg tgatttgata tattttccta tggataacag cttatttgaa 103500
atcaactggg ttgaaccata tgacccattt tatcaattag gccaaaacgc tattcgtaaa 103560
attacagcag gtaaattcat ttattctggg gaagaaatta atccagttct acagaaaaac 103620
gaaggaatta acattccaga atttagtgaa ttagaactaa atcctgttcg caatcttaac 103680
ggtattcatg atattaatat tgatcaatat gcagaagtag atcaaattaa ttctgaagct 103740
aaagaatatg ttgaacctta tgttgttgtc aataacagag gaaaatcttt cgaatctagc 103800
ccatttgata atgatttcat ggattaataa atattataaa ctaattaaag cccagattag 103860
gagaaatcat gtttggttat ttttataatt cgtcttttag acgatatgct accttgatgg 103920
gcgatttgtt ttcaaatatc caaatcaagc gtcagttaga atctggtgat aagtttatac 103980
gtgttcctat tacgtatgca tcaaaggaac actttatgat gaaattgaat aaatggacat 104040
caataaattc acaagaagat gtagctaaag ttgaaactat tctacctcgt ataaatttgc 104100
atttagttga ttttagctat aacgctccat ttaaaacaaa cattttaaat cagaatttac 104160
tgcaaaaagg tacaacttct gtagtatcgc agtataatcc atctcctatt aaaatgattt 104220
atgaattgag tatctttact cgctacgaag atgatatgtt tcaaatagtt gaacagattc 104280
ttccatattt tcaacctcat tttaatacaa ctatgtacga gcagtttgga aatgatattc 104340
catttaaaag ggatattaaa attgtactga tgtctgctgc tatagacgaa gctatagatg 104400
gggacaattt atctcgtcgt agaattgaat ggtcattaac atttgaagta aatggatgga 104460
tgtatcctcc agtagatgat gcagaaggat taattcgtac tacttataca gattttcatg 104520
ctaataccag agatttgcct gatggcgaag gcgtttttga atctgttgat aatgaagttg 104580
ttcctcgaga tattgaccca gaagactggg atggaacagt aaaacaaact ttcactaaca 104640
atgtaaatag accaacaccg ccagaacctc ctggcccaag aacatagagg ttattatgga 104700
aggtcttgat ataaacaaac ttttagatat ttctgacctc cccggaattg acggggagga 104760
aattaaagta tatgaacctc tgcaattagt agaagttaaa agcaatccac aaaaccgtac 104820
tccagattta gaagatgatt atggagtagt tcgtcgaaat atgcattttc aacaacaaat 104880
gctaatggac gcggccaaga tttttcttga gacagcaaag aatgctgatt ctcctcgtca 104940
catggaagta tttgcaactc ttatggggca aatgactacg acgaacagag aaatactgaa 105000
gcttcataaa gatatgaaag atattacatc tgagcaggtt ggcaccaaag gcgctgttcc 105060
tacaggtcaa atgaatattc agaatgcgac agtattcatg ggttcaccaa cagaattaat 105120
ggacgaaatt ggtgatgctt acgaagctca agaagctcgt gagaaggtga taaatggaac 105180
aaccgattaa tgcattaaat gatttccatc cgttaaatga agctggaaaa attttaataa 105240
aacacccaag tttagcggaa agaaaagatg aagacggaat tcattggata aaatctcagt 105300
gggatggaaa atggtatcct gaaaaattca gtgattacct tcgtctgcat aaaatagtaa 105360
aaattccaaa caactctgat aagcctgaat tatttcaaac ttataaagat aagaataata 105420
aaagatctcg gtatatgggt cttcctaact tgaaacgagc taatattaaa acacaatgga 105480
ctcgtgaaat ggttgaggaa tggaaaaaat gccgagatga tattgtttat tttgcagaaa 105540
catactgcgc tattactcat attgactatg gtgtcataaa ggttcaatta cgtgactatc 105600
aacgtgatat gctcaaaata atgtcatcta aacgtatgac tgtttgtaat ctatcacgtc 105660
agcttggtaa aacaactgta gtagctattt tccttgcaca ctttgtatgt tttaacaagg 105720
ataaagctgt aggtattctt gcgcacaaag gctcaatgtc tgcggaagtt ttagaccgta 105780
ctaagcaagc aattgaactg cttcctgact ttttacaacc aggaattgtt gaatggaata 105840
agggttcaat tgaacttgat aatggttcct caatcggagc ctatgcttcc tctcctgacg 105900
cagttcgtgg taactcgttc gcaatgattt acattgacga atgtgcattt attccaaact 105960
tccatgattc ctggcttgct attcagccag taatttcatc tggtcgtcgt tcgaaaatta 106020
ttattactac gactcctaat ggattaaatc atttttatga tatttggact gcagccgttg 106080
aaggtaaatc tggatttgaa ccatacactg ctatttggaa ttcagttaaa gaacgtcttt 106140
ataacgatga agatattttt gacgatggat ggcaatggag catacaaacc attaatggtt 106200
ctactttagc tcaatttcgt caagaacaca ccgcagcatt tgaagggact tctggtacat 106260
taatttcagg aatgaaatta gctgttatgg atttcattga agtaactcca gatgatcacg 106320
gttttcatcg atttaaaagc cctgaaccag atagaaaata tattgcaact ctagactgct 106380
cagaaggtcg tgggcaagat taccacgctt tacatattat tgatgttacc gatgatgtgt 106440
gggaacaagt tggtgtttta cactcaaaca ctatctctca tttaattcta cctgacatcg 106500
ttatgcgtta tttagtagaa tataatgaat gcccagttta tattgaatta aatagtactg 106560
gtgtgtcagt tgctaaatcg ctttatatgg atttagaata cgaaggcgtt atttgcgatt 106620
catatactga tttaggaatg aagcaaacta aacgcacgaa agcagtagga tgttccacat 106680
taaaagacct tattgaaaaa gataagctta ttattcatca ccgagcgact attcaagaat 106740
ttagaacgtt tagtgaaaaa ggcgtgtctt gggcggctga agaaggttat catgacgatt 106800
tagtaatgtc tttagtgatt tttggatggt tatcaacaca atcaaaattt attgattatg 106860
ctgataaaga tgacatgcga ttagcatctg aagtgttttc aaaagagctt caagatatgg 106920
gtgatgaata cgctccagtc atatttgttg attcggttca ttctgctgag tatgttccag 106980
tatctcatgg tatgtcaatg gtataaatat attaaagcat attaaagagg attaaaaatg 107040
actttattat ctccgggcat tgagctcaaa gaaactacgg ttcaaagcac cgtggttaat 107100
aactctactg gtacagcagc tttggccggt aaattccagt ggggtcctgc ttttcagatc 107160
aaacaggtta caaatgaagt agatttagtt aatacttttg gtcaacctac agctgaaact 107220
gctgactatt ttatgtctgc aatgaatttc ttgcagtacg gaaatgactt acgagtagtt 107280
cgtgctgttg atagagatac cgctaaaaac tcatctccga ttgctggtaa tattgaatac 107340
acaatttcta ccccaggtag taactatgca gttggagata aaatcacggt caaatatgtt 107400
tcagatgata ttgaaactga aggtaaaatt actgaagtag acgcagatgg aaaaattaag 107460
aaaattaata ttcctactgc aaaaattatc gctaaagcaa aagaagttgg tgaatatcca 107520
acactaggtt ctaattggac tgcagaaatt tcttcatctt cttccggttt agctgcagta 107580
ataactcttg gaaaaattat tactgattcc ggtattttat tagctgaaat cgaaagcgct 107640
gaaactgcta tgacagcagt tgattttcag gcaaatcttg aaaaatatgg aattccagga 107700
gtagtagctc tctatccagg cgaattaggc gataaaattg aaattgaaat cgtatctaaa 107760
gctgactatg cgaaaggcgc ttctgcatta ctcccaattt atccaggtgg tggtactcgt 107820
gcatctactg ctaaagcggt gtttggatat ggaccacaaa ctgattcaca gtacgctatt 107880
atagttcgtc gaaatgatgc tattgttcaa agcgttgttc tttcaactaa gcgtggtgaa 107940
aaagatattt acgatagtaa catctatatc gatgactttt tcgcaaaagg tggttcagaa 108000
tatatttttg caactgcaca aaactggcca gaaggcttct ctggaatttt aactctgtct 108060
ggtggattat catcaaatgc tgaagtaaca gcaggagatt tgatggaagc ttgggacttc 108120
tttgctgacc gtgaatctgt tgacgttcag ttgtttattg cgggttcttg tgccggtgaa 108180
tctttagaaa cagcatctac tgtccaaaaa cacgtcgttt caattggtga tgctcgccag 108240
gattgcttag tattgtgctc accaccgcgt gaaactgtag ttggaattcc tgtaacccgt 108300
gctgttgata acttagtcaa ttggagaact gcagcaggtt catatactga taataacttt 108360
aatattagtt caacctacgc agcaattgat ggtaactaca aatatcagta tgacaaatat 108420
aatgatgtga atcgttgggt tccattagca gctgatattg ctggtttatg cgcgagaacc 108480
gataacgttt ctcagacttg gatgtctcca gctggttata atcgtggcca gattcttaac 108540
gttattaaac ttgctattga aactcgccag gctcagcgcg accgtttata ccaagaagct 108600
atcaacccgg taactggtac aggtggtgat ggttacgtat tgtatggtga taaaacagct 108660
acttctgttc cttctccatt tgatcgtatt aacgttcgtc gtctgtttaa tatgttgaaa 108720
acgaatatcg gacgtagttc aaaatatcgt ttgttcgaat taaacaatgc gtttactcgt 108780
tcttcattcc gtacagaaac tgctcagtac ttgcaaggaa ttaaagctct tggcggaatt 108840
tatgaatatc gtgtagtttg cgatacaaca aataacactc cgtcagtaat tgatagaaat 108900
gagtttgttg caacattcta catccaaccg gcgcgcagta taaattatat ccagcttaac 108960
ttcgttgcga ctgctactgg tgcagatttc gatgagttaa ctggtcttgc tggttaatac 109020
ggtgcattct aaaggcctgt ttcgacaggc catataaata cactatatcc ttaattcttt 109080
aattctatat gccctaggtt aaacataggg atataaatac tacagaggct aatatgtttg 109140
tagatgatgt aacacgagcg tttgaatctg gtgattttgc tcgacctaac ttattccaag 109200
tagaaatttc ttatcttgga caaaatttta cgttccaatg taaagccact gctttaccag 109260
ctggtattgt agaaaaaatt ccagtcggat ttatgaaccg taaaattaac gtagcaggtg 109320
atcgtacatt cgatgactgg actgttacag taatgaacga tgaagctcat gatgctcgcc 109380
agaagtttgt tgattggcaa agcattgctg ctggtcaagg aaacgaaatt actggtggaa 109440
aacctgcaga gtataaaaag agcgctattg ttcgtcaata tgctcgtgat gctaaaacag 109500
taacaaaaga aattgaaatt aaaggtctgt ggcctactaa cgtgggtgaa cttcaattag 109560
attgggattc aaacaatgaa atccaaacct ttgaagtaac tcttgctctc gattattggg 109620
aataaaatga atggggagaa atccccatcc tgcttaaagc agagaagtcc attataaata 109680
taactataat tcccatttgg agaatacaat gaaatttaat gtattaagtt tgtttgctcc 109740
atgggctaaa atggacgaac gaaattttaa agaccaagaa aaagaagatc ttgtttccat 109800
tacagcccca aagcttgatg atggagcaag agaatttgaa gtaagctcga atgaagctgc 109860
ttctccttat aatgctgcat tccaaacaat ttttggttca tatgaaccag gaatgaaaac 109920
tactcgtgag cttattgata cataccgtaa tctcatgaat aactatgaag tagataatgc 109980
agtttcagaa atcgtttcag atgctatcgt ctatgaagat gatactgaag tcgtagcgtt 110040
aaatttggat aaatctaaat ttagcccaaa aattaaaaat atgatgttag atgaatttag 110100
tgatatatta aatcatctat cgtttcaacg aaaaggttct gatcatttta gacgttggta 110160
tgtcgattca agaattttct tccataaaat cattgatcca aaacgtccaa aagaaggcat 110220
aaaagaatta cgtagattag accctcgcca agttcagtat gttcgtgaaa ttataaccga 110280
aactgaagct ggcacaaaaa tagttaaagg ttacaaagaa tattttatat atgatactgc 110340
ccatgagtca tatgcatgtg atggtagaat gtatgaagct ggcacaaaaa taaaaattcc 110400
taaagctgct gtcgtttatg cccattctgg attagtcgat tgctgtggta aaaatatcat 110460
cgggtattta catcgtgctg ttaaacctgc taaccaatta aaattattag aagatgctgt 110520
agtcatttat cgtattactc gtgctcctga ccgtcgtgtt tggtatgtag acacaggtaa 110580
tatgcctgct cgtaaagctg ctgagcacat gcagcatgtt atgaacacga tgaaaaaccg 110640
tgtagtatat gatgcatcga caggtaaaat aaaaaatcaa cagcataata tgtctatgac 110700
cgaagactat tggttgcagc gccgtgatgg taaagctgtg acagaagttg atactcttcc 110760
tggcgctgat aatactggca atatggaaga tgttcgttgg tttagacaag ctctttatat 110820
ggcattacgt gttcctcttt cacgcattcc gcaagaccaa caaggcggtg tgatgtttga 110880
ttctggaact agcattacac gtgatgaatt aacgtttgct aaatttattc gtgagctgca 110940
gcacaagttt gaagaagttt tcctagatcc acttaaaaca aatcttttgc ttaaaggtat 111000
aatcacagaa gatgagtgga atgatgaaat aaataatatt aagatagaat ttcatcggga 111060
tagctacttt gctgagctca aagaagcaga aattttggaa cgaagaatta atatgctaac 111120
catggcagaa ccatttattg gtaaatatat ttctcacaga actgctatga aagatatttt 111180
gcagatgact gatgaagaaa tagaacaaga agccaagcaa attgaagaag agtctaaaga 111240
ggctcgtttc caagaccccg accaagaaca agaggatttt taatggaagg tttaattgaa 111300
gctattaaat caaacgacct cgtagccgct cgtaaattat ttgctgaagc catggctgca 111360
agaacgattg atttaattaa agaagaaaaa atcgctatcg ctcgtaattt cttaattgaa 111420
ggtgaagaac ctgaagacga ggatgaagat gatgacgaag atggtgatga taaagacgac 111480
aaaaaagaca aagactctga cgaagatgac gaagacgagg atgatgaata atgcttctga 111540
tccctgaaac tcatgaatta gttctcgaga atgtcgaagc acttattcct gaagcacagg 111600
gtcgctttga cgaattgtct tctgctttaa ataaagacga tataaataca attgtcgaga 111660
atatgcttga tgatgaaact gatttagcag ttgcattagc ttctattaat gaaaatatgc 111720
cgttaaatga attcatcgtt aaacatgttt ctgcccgtgg tgaaattact cgcactaaag 111780
atcgcaaaac ccgcgaacga aatgcatttc aaaccaccgg gctgtctaaa gcaaaacgta 111840
gacaaattgc tcgtaaagct accaaaacga agattgccaa tccagcaggt caatctcgtg 111900
ctcagcgtaa gcgtaaaaaa gctcttaaac gccgtaaagc attaggatta agctaatgaa 111960
tgaaccccaa ttactaattg aaacttgggg tcaacctggc gaaattattg atggtgtgcc 112020
aatgcttgaa tcccacgatg gaaaagacct aggtttaaaa ccgggtttat acatcgaagg 112080
aatattcatg caagcggaag tcgtcaatag aaataaacgt ctttatccaa aacgcatatt 112140
agaaaaagcg gtaaaagact atatcaatga gcaagtttta actaaacaag ctctcggaga 112200
attaaatcat cctccacgcg ctaatgttga cccgatgcaa gccgctatca ttatagaaga 112260
tatgtggtgg aaaggaaatg acgtatacgg acgagctcgt gttattgaag gtgaccatgg 112320
tcctggagat aaattagcag ctaatattcg tgccggatgg attccaggag tttcttctcg 112380
tggattaggt tcattgactg acacaaataa aggttatcgt atcgtaaacg aaggattcaa 112440
attaactgta ggtgttgatg cagtatgggg tccaagtgct ccagatgcat gggtaactcc 112500
taaggaaatt accgaatcac agacggcgga agccgataca agtgccgatg acgcctatat 112560
ggctctcgca gaggccatga aaaaagcgtt ataaatatta ttatctaaac aacaggacta 112620
caaaatgctt aaagaacaac tgattgccga agcgcagaaa attgatgctt ccgttgctct 112680
tgatagtatt ttcgaatcag ttaatatttc tccggaagca aaagaaactt tcggcactgt 112740
attcgaagct accgtcaagc agcacgccgt taaattagct gaatctcata tcgctaaaat 112800
tgctgaaaaa gcagaagaag aagtagaaaa aaataaagaa gaagcagaag aaaaagctga 112860
gaagaaaatc gctgagcaag cttctaaatt ccttgaccat cttgcaaaag aatggctcac 112920
tgaaaataaa ttagcagtag ataaaggtat caaagccgaa ctgtttgaat ccatgcttgg 112980
tggattgaaa gagctcttcg ttgaacacaa cgttgttgtt ccagaagaat cagttgatgt 113040
tgtagctgaa atggaagaag agctgcaaga acataaagaa gaatcagctc gtctgttcga 113100
agaactcaat aagcgtgacg catatatcaa ttatgtgcag cgtgaagtgg cattgagcga 113160
aagtactaaa gatctgactg agtctcaaaa agaaaaagtc tctgctctgg tcgaaggtat 113220
tgattattca gatgcattct caagcaaatt gagtgccatc gtagaaatgg tgaagaaatc 113280
taataaagat gaaagcacta ttactgagag tataaatact cctgatactg aagcagccgg 113340
actgaatttc gtcactgaag ctgtagaaga taaatctgca caaggtgcag aagatattgt 113400
aagtgtatat gcgaaagtcg catctcgttt ctaattttaa aggttaacac aaatgactat 113460
caaaactaaa gctgaacttt tgaacaaatg gaagccatta ctggaaggtg aaggtttacc 113520
ggaaattgct aatagcaaac aagcgattat cgctaaaatc tttgaaaacc aggaaaaaga 113580
tttccagaca gctccggaat ataaagacga aaaaattgct caggcattcg gttctttctt 113640
aacagaagct gaaattggtg gtgaccacgg ttacaatgct accaacatcg ctgcaggtca 113700
gacttctggc gcagtaactc agattggccc agctgttatg ggtatggtac gtcgtgctat 113760
tcctaacctg attgctttcg atatttgtgg tgttcagcca atgaacagcc cgactggcca 113820
ggtattcgcg ctgcgcgcag tatatggtaa agatccaatc gcttccggcg ctaaagaagc 113880
attccaccca atgtatggtc cagatgcaat gttctctggt cagggtgctg ctaagaaatt 113940
cccagctctg gctgctagta ctgaaactgt tgtaggtgat atctatactc acttcttcca 114000
ggaaaccggt actgtatatc tgcaagcttc agctgttgtg acaattgatt ctagtgcaaa 114060
tgatgcagct aaattagatg ctgaaattaa gaaacaaatg gaagcaggtg tactggtaga 114120
aatcgctgaa ggtatggcta cttctatcgc tgaactccag gaaggtttta acggttctac 114180
cgataaccca tggaatgaaa tgggcttccg tatcgataag caagttatcg aagctaaatc 114240
tcgtcagctg aaagctgctt actctattga attagcacaa gacctccgtg ctgttcacgg 114300
tatggatgct gatgctgaac tgtctggtat tctggctacc gaaatcatgc tggaaatcaa 114360
ccgcgaagtt gttgattgga ttaactactc agctcaggtt ggtaaatctg gtatgaccct 114420
gactccaggt tctaaagctg gtgtatttga cttccaggat ccgattgata ttcgtggtgc 114480
tcgctgggcg ggtgaatcct ttaaagctct gttgttccag attgacaaag aagcagttga 114540
aattgctcgt cagaccggtc gtggtgaagg taacttcatt atcgcttccc gtaacgtagt 114600
taacgttctg gcttcagttg ataccggcat ttcttatgct gcacagggtc tggctaccgg 114660
ctttaacact gatactacca agtcagtatt tgctggtgtt ctgggtggta aataccgcgt 114720
atatatcgac cagtatgcta aacaagatta tttcactgta ggttataaag gtccgaacga 114780
aatggatgct ggtatttact atgctccata tgtagctctg actccgctgc gtggttccga 114840
tccgaagaac ttccaaccag taatgggatt caaaactcgt tacggtatcg gtatcaaccc 114900
atttgcagaa tccgctgctc aggctccggc ttctcgcatc cagagcggta tgccttctat 114960
cctgaacagc cttggtaaaa acgcttactt ccgccgtgta tatgttaaag gtatctaatc 115020
tttgacgatt taagggacct tcgggtccct ttagttgttt ttatggtata aataaatcat 115080
ataaactgaa aggaaagcgc aatggctaaa atcaacgaac ttctgcgcga atcaaccaca 115140
acgaatagca actcaatcgg tcgcccaaat ctcgttgctt tgactcgcgc taccactaaa 115200
ttaatatatt ctgacattgt agcaacgcaa agaactaatc aacctgttgc tgctttttat 115260
ggtatcaaat accttaaccc agacaatgaa tttacattta aaactggtgc tacttatgct 115320
ggcgaagctg gatatgtaga ccgagaacaa atcacagaat taacggaaga gtctaaatta 115380
actcttaata aaggcgattt attcaaatat aataatatcg tttataaagt attagaagat 115440
acaccatttg ctgatattga agaaagtgat ttagaattag ctcttcagat tgcaattgtt 115500
cttttaaagg ttcgtctatt ttctgacgca gcgtcaacaa gcaaatttga aagctctgat 115560
agtgaaattg cggatgctag attccagatt aataaatggc aaaccgcagt taaatctcgt 115620
aaacttaaaa ctggtatcac agttgaatta gcacaagatt tagaagcaaa tggattcgat 115680
gctcctaatt tcttagaaga tttgcttgca actgaaatgg cagatgaaat caataaagat 115740
attctgcagt ctttgattac agtatcaaaa cgttataaag ttacaggaat tactgatact 115800
ggattcattg atttgagtta tgcatctgca cctgaagctg gtcgttcatt ataccgaatg 115860
gtatgtgaaa tggtttcgca tatccaaaaa gaatcaactt atacagcaac gttttgtgtt 115920
gcttcagctc gtgccgctgc gattcttgct gcatctggtt ggttaaaaca taaaccagaa 115980
gatgataaat atctttcaca aaatgcctac gggttcttag ctaatggttt accgctttat 116040
tgcgatacta acagcccatt agattatgta atcgttggcg tagtagaaaa tatcggtgaa 116100
aaagaaattg ttggatcaat tttctatgct ccgtatacag aaggtctcga cttagatgac 116160
cctgaacatg taggtgcatt taaagttgtt gttgatccag aaagcttaca accgtctatc 116220
ggtttattag ttagatatgc tttatctgca aatccttata ccgtagcaaa agatgaaaaa 116280
gaagcaagag taattgatgg tggagacatg gataaaatgg cgggtcgttc agatttgtct 116340
gttttattag gtgttaagct accaaaaatt attatcgatg aataaaacaa agggaccttt 116400
cggtcccttt ttatttagct caccaactca atccaagccg gacgaagtac atcttgtacc 116460
attttaacta attccttttt aatcaaagaa ggattatctg cttgagttag agtaatacct 116520
tcacgagaag tttcttccaa aatatcttgg acagttagcc ccatcacctt tccaaaatcc 116580
tttggaccaa tttcgccaat tttagaaata acgttattta ctcggttcag tgtaacgtaa 116640
caagctaaaa ttcccaccaa tttgttatca gcttctgaca attcaacttt agctttaata 116700
ggcttatcag actttttctt ttcactaaat ttagaattct tgcatttgat ggctacacga 116760
ttgcgattag gcagccaaga aggctaacaa ggtttcaata catatccttc agcggtaaat 116820
acttcgcctt tggcttcggc attccaaacg catttatttg catcaactaa tccagcatgg 116880
tctactgtaa aattataatc ttggacgaca gaatctaaat catttggcaa tttaataagc 116940
tcttcaaatt taccgcgacc taaaagtgga gccattttaa atttaaatgt attgcagaat 117000
gattccatca tataatcatc gacataagtc acgtcaccac tttctgtagt gacaataatg 117060
tcaaatacat aaaaatcttt atcaccataa tcaacattct tctgaatgcc aggtccagcg 117120
aattcgccaa aaacttgata agtcacaaca gctgaagttt ccataatatc ttgtactgct 117180
ttaatggaat cagcgtaatt ctttagaata atttcatacc caaagaaatc ttcagcagga 117240
agaatcggtc cagtacgttt agcgcaagtt actttatcac gctcaataat caatgagaaa 117300
tttgtgccgt gaatcttttc acgagctacc cattcgccgc cagtcaatcc caagctataa 117360
agtttttcaa taaatttaga gttgtaatga ttttcaagac tgctatactt tttaaacata 117420
attaatcctc aaaatgtaat ttctaaccaa tcaccatcac gctgatcact attgacttta 117480
aaattaaatc cttcttttct cagccaatca ccaatttctt cagtaatcaa tttatcacga 117540
gcagtacaat aataactaaa atatgtttta ccttgttcag ctgctttatt agcaagttct 117600
gaaaaatctt taataaaaca ctctagttta aactgtttac tttttaatgc tttttcacgt 117660
aattgattag caaaagattc attttcataa agatcatact gttccatttt tcaccttttt 117720
attaatgtgt ctttttctat agacaacttt ttctcgagtc tcaaatttat tctttgcagt 117780
catagctcga gcccataata cagccacttc tttcgcctgt aagtttaatt cacgagcaat 117840
ttcaatgaat gactttccag actcatgaag tgtaaacacc acaacttcag ttctcataat 117900
caatctcatg ttatcgagtt ggtgccatta tatacatcat tttctgattg tgttttgtgt 117960
gctttcaaaa tgaagaaagg ggccgaagcc cctttcgatt atggataagt atagatgata 118020
ccagtttcta aagcagtttt atggatgatg tatccattac gtgattcttg aacatcaact 118080
tctggataat ctttcatcat cttctgaagc gtataacgat gcaagtagta cttactatct 118140
ggatcttcag ttttccaatc tttaccttct tcagtcattt tttggatttc atccataacc 118200
caccaaccgc accagatata agctgaagta cgatgtggaa gaggatgaac ataaggcaat 118260
tcaccttctg gttccggagc aactttatca gttacctgaa cttgacctgt tgttttaact 118320
gttttgctat catagtcagt tgctgtaacg acagcagtaa cttcaatagt ttgacttcca 118380
acagatgagg tatcaacagt atatacgtta gttgaccctt ctacaggaga agaatctttc 118440
ttccatgagt aagtaatttg tgcttcttct ggagcatccg taacattagc agtaaatgta 118500
gccgaagcat cttgctgaac gttaatagaa ggaggagtca atgtaacctg tggattcatt 118560
gtcttcttat taactgtcaa tgatacttca ttagaagtaa cttccttttc attgtaattt 118620
tctgctgtta cttgggctac gcatttaatt ctttttactc cacttgtagt tggagtatag 118680
ctaaatgtag agctagtttc tccaccaact tgtgaatcat ctacatacca ctgatacgta 118740
gcagatgctc catcaggttg agaagctaag gcagcagtaa attgaactgg ggttccaatt 118800
actccagctg aaggactagc aggagttact gccaatgtag ttgtctgtgt ctttttatta 118860
acagtcagtg atacttcatt agaagtaacg gttttttcat cataatttgt cgcggttact 118920
tgagctacac acttgatttt tttaactccg cttgcggcag gagtgtaatt gaatgtagca 118980
gaagtcgctt cgtctacagg agaactgtca acgtaccatt gatacgtagc agatgcacct 119040
gatggctgcg aagctaaagc agcggtaaat ttaacagctg ttccaattac tcctgctgga 119100
ggactattgg gagttacggc taaggtagtc gtctgagttt tgtttttgac tgtgatagtt 119160
gtagtagctt ctgctgtttc agcttcagat tctggaactg tatttgttgc aacaacttta 119220
atagtctttt gaccagcagg accttttaat acataatcaa aagttgcttc agacccatct 119280
tgtggagcat tatctacact ccaagcataa gtaatagttc cacctccagt ttcaccacta 119340
ggtgcagcag taaactgctt ggtttcatca ataactcctg acggtgtttt aggagttata 119400
tcaactgtaa aagccataag ttatccttat tttaatgtta cgaaagaaga attgcgtgtt 119460
tcacgaatta aaactgatcc gtcgcgatta atgtaataaa ttaagctaaa caaagtttgg 119520
tgtgctgacg cgtgttcaaa actagttggg tgagatttcc aatccggagt ttcagcaatc 119580
cactggtaaa tccaccaagg aacggtacag aatcctggat tttttccaat caactgaaga 119640
ttcggactaa agttttccgg aagagtaaat acagacggct tttcagattc aataatctca 119700
gctacagcct gttcgaattt ttcttcaaca aaaggagtat cttcaattaa aacagtagta 119760
ttttcaggaa ttttatccgt ttctactact tcaattttaa tgtcagattt aaccggagaa 119820
tcaatcagaa gtgctgcctc tggattgact tcttcatcgt catattttaa tccgtctgcg 119880
gcatcagcag catcaattaa gtctttaata gataacccat cagtctctgg cataggttca 119940
ctagcgagct tctggagagc ttcttcaata tcattaacga tattatcaaa agatttattc 120000
tttttgacct ttataccaaa ctgttcagcg tattcagcta atttagcttt agcttcttta 120060
ttatcatcaa gagccttcag ctctgcaata taatctttat ctatcataat atttcctcag 120120
tataaatata gatatattta ttactcggaa aatagtatgt accactttgt atatgaaaca 120180
acaaatctaa taaatggtaa aaagtatata ggaaaacact ctactgatga cttgaatgat 120240
ggttaccttg gttccggtaa ggcaattcag caggctataa agaaatatgg tgaaaacaat 120300
ttctctagaa caatactaaa agagtttaaa acttccgaag aagcgtacat gtatgaagaa 120360
gaaattataa ctcctgaaat aataaaaagc aaaaattatt ataatatgaa acctggtgga 120420
attggtggaa ttgttatgac tacagaggtt atagcaaaga tgaaagaatc ttccgctaag 120480
agatttgaaa actcaccggg cacggtatta ggtacaactt gttacactaa tggaactaaa 120540
aatattttta ttaaacctgg agaacttgtt ccagaaggat ttgtaaaagg gatggttcat 120600
cctaatagaa agtccagaaa aggatgtaaa gtcaaaccaa ctaccacagg aactttttgg 120660
gtcaataatg gtgcaataaa taaattaata caaccagacg gtattattcc cgacggattt 120720
attaaaggtc gtctcatgaa aagagattct aaaggcaaat ttagtaaggc ataattatgg 120780
atattaaagt acattttcac gacttcagcc atgtacgcat cgattgtgaa gagagcacgt 120840
tccacgaatt aagagatttc ttttcgtttg aggccgatgg atataggttt aatcctcgct 120900
tcagatatgg caactgggat ggacgaatcc gtcttttaga ttataatcgt cttcttccat 120960
tcggcttagt cgggcaaatt aaaaagttct gtgataactt tggctataaa gcctggattg 121020
acccacaaat taacgaaaaa gaagaattat caagaaaaga ttttgatgaa tggctttcta 121080
aattagaaat ctattcagga aataaaagaa ttgaaccaca ctggtatcaa aaagatgcag 121140
tgttcgaagg attagttaat cgtcgtagaa ttcttaatct tccaacatct gcaggtaaat 121200
ctttaattca ggctctgctt gcgcgatatt atttggaaaa ttatgaaggt aaaattctta 121260
tcattgttcc aacaactgct ctgacaactc agatggctga tgactttgtt gattatcgtt 121320
tattcagtca cgcaatgata aagaaaattg gtggcggagc atcaaaagat gataaatata 121380
aaaatgatgc accagtcgtt gttggtacat ggcaaactgt agtaaaacaa ccaaaagaat 121440
ggttctcaca gtttggaatg atgatgaatg atgaatgtca tcttgctaca ggaaaaagta 121500
tttcatctat catatcaggt ttaaataact gcatgttcaa atttggtcta tctggttcat 121560
tacgtgacgg caaagccaat atcatgcagt atgttggaat gtttggcgaa atatttaagc 121620
cagtaacgac ttctaagtta atggaagatg ggcaagtaac tgagctaaaa attaatagta 121680
tttttcttcg ttatcctgat gagttcacta ctaaattaaa gggaaaaact taccaagaag 121740
aaataaaaat tattactggg ctcagtaaaa gaaataaatg gatagctaaa ttagctatta 121800
agcttgcgca aaaagatgaa aacgcttttg tcatgtttaa acatgtatca catggtaaag 121860
ctattttcga tttaattaaa aatgaatacg ataaagttta ttacgtatca ggggaagttg 121920
ataccgaaac ccgcaatata atgaaaacct tagctgaaaa tggcaaagga ataattatag 121980
tagctagtta tggtgtattt tctactggta tttcagttaa aaatctgcat cacgttgttt 122040
tagcgcacgg tgttaaatca aaaatcattg tattacaaac aatcggtcgt gtattacgta 122100
agcatggttc taagacaata gcaacagtct gggacctcat agatgactgt ggtgttaagc 122160
caaaatctgc taatacgaaa aagaaatatg ttcatttgaa ctatctttta aaacacggca 122220
ttgatcgtat tcagcgctac gcagatgaaa aattcaatta cgtaatgaaa acagttaatt 122280
tataagggct tcggcccttt ggagaaaaag atgttactag aatttaaaca atttctttat 122340
gaagcttcta ttgatgaatt tatgggtaaa attgcctctt gtcaaacatt agaaggttta 122400
gaagaacttg aagcttatta taagaaaaga gtcaaagaaa ctgaattaaa agacactgat 122460
gacatctctg tgagagatgc tttagcagga aaaagagctg aattagaaga ttcagacgat 122520
gatgaagtag aagaaagctt ttaaattaaa aaaggcccaa ccgaaaagga agggccaaaa 122580
ctatagacta aaggtcacac tatagcaaaa gttgtgtttc atttaattgt tcttccgaac 122640
tttctgaaac tggtagttct ttaatgtaat tatagcaagg cccaggatgt acaggacctt 122700
tgtctgtttc aacaaccaat gcagaatcga ttggagtttt acagacaaca caaatcttat 122760
ctgacatgat tgtctcctct gaattatata tctatttata caactctcat atgcatatca 122820
atgcccatat ctttagaata aaaatattca tcaagatatc cggcaaattt tcctttaaca 122880
taaaggacat cttcaccgca tggatggtcg gccaggatac gaatatcctg acgcttaaga 122940
ttatgctttt tcattaagaa ttgaatctca gtttcaaatt cttcttcata attaaaagca 123000
tcatcaatgt tatatctcat tattttccag cctcaaatgc ccgcatgtct tgaatatgct 123060
taatagcaaa tccgcgtgat ttgatagcat caagagctcc gctacagaaa tctaataaaa 123120
ttccccaata ttgtaatgaa gtatcaacct ttaaaacatc cttatcagct gatagaactg 123180
ttttcatttc tgatttctcg taacgatcca tactaaattc atcaccatct cctcgtcccg 123240
agtagtagtc taatttagct ttaagagcaa cttttttctg tgcttcaatt ctaagcattt 123300
cctttttaat acttgaatgc ttattaagcc atttactata taacatcaca ttattagctg 123360
cttcatactg taatttagtc gaatctataa acacatcttt cttcaattct tcttgaagat 123420
cttctaatct catattgttc tctattcaat tgttattgga tggacttaga ttcattatac 123480
cacgttttaa cgtgaagcat tataccctat tactggaagc cagttgcagt tttatctgct 123540
caatatcatc aggattatcg atgactgaaa agcgtatttc tactatcaaa gtataatcat 123600
cataaaccgg tattacatta actgctaatt tatcaatacg tggctcatag tttcttactg 123660
cgctttcgat attacgctca accgtgtcag cagtaagagg agtcatattc tcaaaaagtt 123720
ggtcagataa atcgcatcca aattcagggt caaacggtct tgaacctttt cttgttgtaa 123780
taattcctaa aagactattt ttaattgacc ttaatccaag tgatcttgaa acgtctttgt 123840
tccaatccat tttcatctct gggtcaatat cagaataaag cttattaata tttgccatta 123900
caatagctca aagaattctt tgagtcctct tattacatga gcgtgggttt ttccacactc 123960
tggacattta attggaacag ccaaataaac agtaggcttt aaaagcatat cttttatagc 124020
tacaatatct gactctgtga tgatagaata taaatcttcc aattcttttt catttaagtc 124080
ttcaactgga atgctttcac cgttagcatg aatcgtttct atacatgata ctatcatgtg 124140
ggctatattt ttatcatcaa aaattttagg gtaatggaat ttaattttaa tgtcacccag 124200
tgtataccag aggtcttctg gtgcatctat ttgtgtatgt aatagattta tatgggttgg 124260
tatttcagtt ccacaggtgc acttccagga gttttcgtga ttaacttctc caagagaatg 124320
cgcccataaa tgaatcagta atagttctga ttcttggcgg tttaaatctt ttgcatttgt 124380
gcagtctttg attagctttt taacaattac ttctacggaa ccattatttt tggcagtaat 124440
aagttctaga tattctttaa gagtaaatgc acgacagttg attattttag aaccaactct 124500
cacgtcaaat ttgtattcat acatatttag ctcctttatt tatcatattt ataaatagaa 124560
taaaaggagc atctatggca aacattattc gttgtaaatt acctgatggt gttcatcgtt 124620
ttaaaccatt tacggtagaa gattatcgag attttttgtt agttcgaaac gatatagaac 124680
atcggtcatc acaagaacaa aaagaagtaa ttgctgattt aattgctgat tattttggag 124740
actatccaaa gacttggcaa ccatttatat ttttgcaggt atttgtaggt tcaataggta 124800
aaactaaagt accagtcaca ttcatatgtc caaaatgtaa aaaagaaaag acagttccat 124860
ttgaaatata tcaaaaagaa ttaaaggaac ctatttttga tgtagctaat gttaaaatta 124920
aattaaattt tccttctgag ttttatgaaa ataaagcaaa gatgattact gaaaatattc 124980
attctgttca agtagatgaa atgtggtatg attggaagga aattagtgaa tcaagtcaaa 125040
tagaacttgt tgacgccatc gagatagaaa cattagaaaa aattctcgat gcaatgaatc 125100
ctattaattt aacattgcac atgtcgtgtt gtgataagta cattaaaaaa tacactgata 125160
tagtagatgt gtttaagcta ttagttaatc cagatgagat atttactttt tatcaaatta 125220
atcacacgct tgtaaaaagt aattatagct taaattcaat aatgaaaatg attcctgccg 125280
agcgcggatt cgtattaaaa ctgattgaga aggataaaca ataatgagta tgttgcaacg 125340
ccccggatat ccaaatctca gcgttaaatt atttgagagt tatgacgctt ggagtaataa 125400
tagatttgtt gaattagctg ctactattac cacattaact atgcgtgact ctctttatgg 125460
tcgaaatgaa ggaatgctac aattttatga ttctaaaaac attcatacaa aaatggatgg 125520
aaatgaaata attcagattt ctgtagctaa tgcaaacgat attaataatg ttaaaacacg 125580
aatttatgga tgcaagcatt tttccgtgtc agtagattca aaaggcgata acatcattgc 125640
tattgaattg ggaactattc attctataga aaatcttaaa tttggtagac catttttccc 125700
tgatgccggg gaatctataa aggaaatgct tggtgtcatt tatcaagacc gcacattatt 125760
aactccagca ataaatgcta taaatgctta tgttcctgat attccatgga ctagcacatt 125820
tgaaaactat ttgtcatatg taagagaagt tgctctagcg gtaggaagcg ataagttcgt 125880
atttgtatgg caagacatca tgggagttaa catgatggac tatgatatga tgataaatca 125940
agaaccatat ccaatgattg tgggtgagcc aactttaata ggtcaattcg tccaagaatt 126000
gaaatatcca ttagcatatg attttgtttg gttgactaaa tcaaacccgc ataaacgtga 126060
tccaatgaaa aatgctacta tctatgctca ttcattttta gattcttcat taccaatgat 126120
tactacagga aagggtgaaa actctattgt agtgtcaagg tcaggtgctt attctgaaat 126180
gacttataga aatggatatg aagaagctat tcgtcttcag actatggcgc agtatgatgg 126240
ttacgctaaa tgttctactg tcggtaattt taacttgact cctggcgtta aaattatttt 126300
taatgatagt aaaaaccaat ttaaaacaga attttacgtt gatgaagtta ttcacgaatt 126360
atcaaataat aattccgtaa ctcatcttta tatgttcact aatgcaacga aactggaaac 126420
aattgaccca gttaaggtta aaaatgaatt taaaactgat actaccactg aagaaagtag 126480
ttcttccgat aagtaataaa gaagtttcta ttcctaagat gggtcttaaa cattataaca 126540
ttttaaaaga tgttaaaggt cctgatgaaa atttaaagct tcttattgat tctatttgtc 126600
caaatttatc accggcagaa gttgatttcg tttctattca tttgctagaa tttaatggaa 126660
agattaaatc tcgtaaagaa atagatggtt atacttatga tattaatgac gtttatgtat 126720
gtcaaagatt ggaatttcaa taccaaggaa atacatttta ttttagacct cctggaaaat 126780
ttgaacaatt tttaactgta agcgatatgt tatccaaatg cttgcttaag gtcaatgatg 126840
aagttaaaga aattaatttt cttgagatgc cagcatttgt tttaaaatgg gcaaatgata 126900
tttctacaac tttagcaatt cctggcccta atggtccaat aaccggaatt ggcaatatta 126960
ttggattatt tgaatgaaaa agccacaaga aatgcaaacg atgcgtagaa aagttatttc 127020
agataataaa ccaacacagg acgcggctaa atccgcttct aatactttat ctggtcttaa 127080
tgacatttct acaaaattag atgatgctca agctgcttct gaattaatag ctcagactgt 127140
tgaagaaaaa tcaaatgaaa tagttggagc aattgataac gttgaaagcg cagtaagtga 127200
tactactgcc ggttctgagt taattgctga aactgttgaa attggaaaca atattaataa 127260
agaaatcggt gaatcgctcg gaagcaaatt agataaatta acaagtttac tggaacaaaa 127320
aattcagaca gctggaattc agcaaactgg aacgagttta gcagtagtcg aaaatgctat 127380
tcctgttaaa gtcgtcgagg atgatacagc tgaatctgtg ggtcctttat taccggctcc 127440
tgaagcagtt aataatgatc ctgatgctga ttttttccct actcctcagc caattgaacc 127500
aaaacaagag tctccagaag agaagcaaaa aagagacgca tttaacttaa aattatctca 127560
agctttagat aaattaacaa agacagttga tttcggattt aagaaatcta tttcaattac 127620
tgataaaata tctagcatgc tatttaagta taccgtcagt gctgctattg aagctgctaa 127680
aatggttgca ttgataatgg ctgttgttat tggaatagac ctgctgatgg ttcattttaa 127740
atactggtca gataaatttt caaaagcctg ggatttattt agcactgatt ttactaaatt 127800
ctctagcgaa accggaacat ggggtccttt attacagagc atctttgatt ctattgataa 127860
aattaaacaa ctttgggaag ctggagattg gggcggattg acagtagcta ttgttgaagg 127920
gcttggaagt gttctttata atttaggaga gcttattcaa ttaggtatgg ctaaattatc 127980
tgcagcaatt cttcgagtca ttcctggcat gaaggatact gctgatgaag tagaaggaag 128040
agcattagaa aatttccaaa attctactgg agcatctctt aataaagaag accaagaaaa 128100
agtagcaaat tatcaagata aacgaatgaa tgatgatctt ggcccaatag caaaaggatt 128160
agacaaaatt gcgaactgga aaactcgtgc atctaactgg attcgtggtg tagataataa 128220
agaagcattg actactgacg aagaacgtgc agcagaagaa gaaaaattaa aacaactttc 128280
accggaagaa agaaaaaatg ctttaatgaa agctaatgaa gctcgtgctg cgatgattcg 128340
ttttgaaaaa tacgctgatt cagctgatat gagcaaagac tcgacagtta aatcaattga 128400
agctgctcat gaagacctta aaaaacgaat gaatgatccg gatttaaata attcaccagc 128460
agttaaaaaa gaacttgctt ctagatttgc taaaattgat gccacttatc aagagctcaa 128520
gaaaaatcaa cctgaagcaa aacctgaaac ttctgctaaa tcaccagaag caaaacaggt 128580
ccaggtgatt gaaaagaaca aagcacaaca agctcctgtt caacaagcat ctccttcaat 128640
caataatact aataatgtta ttaagaaaaa tactgtcgtt cataatatga cacctgtcac 128700
aagcacaact gctcctggtg tatttggtgc gacgggagtt aattaaggaa taatatggca 128760
attgttaaag aaataactgc tgatttaatt aaaaagtccg gtgaaacaat ttcagccgga 128820
cagagtacta aatcagaagt aggaactaaa acatacacag cccagtttcc aactgggcgt 128880
gctagtggta atgacactac aggggacttc caggtaacag atctatataa gaatggatta 128940
ttatttactg catacaatat gtcatctagg gattctggaa gtcttagaac gatgagatct 129000
aactactctt cttcatcttc gagtatttta cgtacagcca gaaacactat cagtaataca 129060
gtatcaaaac tatcaaatgg actaatatca gataataatt caggaacaat aagtaaagtt 129120
cctgttgcaa atattctttt acctagatct aaatctgacg tcgatacgtc atcacataga 129180
tttaatgatg ttcaagatag tcttattaca aaaggcggag gtactgctac tggtgtgcta 129240
agtaatatgg cttcaactgc agtatttggt gcgcttgaaa gtataacaca aggaataatg 129300
gctgataata atgaacagat ctatacaaca gctagaagta tgtatggcgg tgctgaaaat 129360
agaacaaaag tgttcacctg ggatttgact ccgcgctcaa cagaagattt aatggctatt 129420
attaatatct atcagtattt taactatttt tcttacggtg aaactggtaa atctcaatat 129480
gctgctgaaa taaaaggata tttagatgag tggtatcgtt ctacatttat tgaaccatta 129540
acgccagaag acgcgattaa aaacaagacg ttatttgaaa aaatgacatc gagtttaacg 129600
aacgttcttg tagtttcaaa cccgacaatt tggatggtga aaaactttgg tgcaacttct 129660
aaatttgatg gaaagactga agtattcggt ccatgccaaa tacagagtat tagatttgat 129720
aaaacaccaa atggtaactt taatggatta gctattgctc ctaaccttcc aagttctttt 129780
acactcgaga ttactatgag agagattatt acgttaaacc gtgcttcttt atatacgggg 129840
actttctaat gtattcttta gaggaattta ataatcaagc aataaacgca gacttccaac 129900
gtaataatat gttcagctgt gtttttgcta caactccatc aactaaaagc tcatcgttaa 129960
taagctcaat tagtaacttt gcttataata acttgggtct aaattcagat tggttgggat 130020
taactcaagg tgatattaat cagggaatta ccacgctaat taccgctggc acacaaaaac 130080
tgataagaaa atcaggggtt agtaaatatc ttattggtgc catgagtcaa cgtacagttc 130140
aaagtttatt aggctcattt acagttggta catatttaat tgacttcttt aacatggcat 130200
ataactcatc tggattgatg atatattctg taaaaatgcc agagaataga ttatcctatg 130260
aaactgactg gaactataat tctcctaata ttcgtataac tggaagagaa ttagaccctt 130320
tggttatttc atttagaatg gattcagaag cttgtaacta tcgtgcaatg caagactggg 130380
ttaacgctgt tcaagaccca gtaactggat tgcgtgcttt accgcaagat gtcgaggcag 130440
atattcaggt caatcttcat tctcgcaatg gattaccaca tactgcggtg atgttcactg 130500
gctgtattcc aatatctgtg agtgctcctg agttatcata tgatggagat aaccaaataa 130560
ctacatttga tgttactttc gcgtatagag tcatgcaggc tggagcagtt gatagacaag 130620
ctgcccttga atggcttgaa tctgctacta taaatggtat tcaaagcgtt ctcggaaata 130680
gtggaggtgt tactggacta tctaattcgc tttcacgact tagtagatta gggggaactg 130740
caggaagcat ttcaaatatt aatactatga caggaattgt caactcgcaa agtaaaatat 130800
taggagcaat ataacaatgg ggaccgaaag gtccccatgt ttttatttac ggaatgaaat 130860
aaaagcagca actgaagcaa cagaggtttc ttcaatataa acctcaattt ttatcggagc 130920
ttctgactca aatttacctg ttactacacc ctgaaaaata ctttcagtct gttctggctt 130980
tgaaaaattt tcagaaggaa aaattccgaa ctttttatct gttccaaaaa ttttgataaa 131040
ttcatcgtaa actgcttcat tgaaagcgtt atcagcggga ataacgcctt caacgacgag 131100
ttcttgacct aaaaagcgca aagaagattt cattttgtgt tcctcatgtt atgtcagtaa 131160
gactactata acacaacacg agggacttgt aaactacatt ttgaactttt tagacattcc 131220
gttgatgtta accaaagaag ctaagatttg agaaacttcg ttttcctctt cttttgattc 131280
ttctacaagg aattgattaa atccagccat tggacgaact tcaccagttt ccattagatg 131340
gtcgccatca tatactgatt cttctaattg ttcagaagga ggaacgattg taccttcgat 131400
tagatacttg ttataagcag tttctttcat aaagtaagta cttactttat taatcttcag 131460
taaaattcca cgtggtagaa taacttcagc ttctgatgga aatcctgaca aatgacctgg 131520
aacgataact ttaactcgtt cagctccttt aattaccata cccacgctag tttcagcatc 131580
ttcattagca tatgtagaat gactacccat atgcatcaaa tcttctgcat caacggaacc 131640
ttctccttca ccagaaaata ctgctccgga atcatctaag gccatataat ttttaccata 131700
ctcaccaaag atatttggtt taagtgatgt agatacgaag ttcttgaaat agaacatttt 131760
attttcaatg ttatgacgca aagttttaaa agtaacttct tgtccacggt aaagtgtagt 131820
tcctggagga agaactgaac ctttagcaaa cgcagaatcc atagtctcga tgtgcttaat 131880
agcgcgctcc atgtattctt cacgtgtaga atcaggttta cctaaaagga atgagttcat 131940
ttcaacatac gaatctgcac aataatcttc aattacatca gattcagcct gagtcaatcc 132000
ttttggagtt acttcagtgc ttgcatattc atacgcctga gcagcggatt catcaattaa 132060
tttataaatg ccattcatga caaattgaat aatagctgtc ttttcatctg gcgtagcttt 132120
agaaccttta actaaatcat tgacaatttt cttaataaca tcaaagctat tagaaatatt 132180
aatgtcagca agatcgctta aaattttatc agttttataa tcaaaaaatt ctttattctt 132240
taaatattct tgagaacttt gatatgttat atcgctctgc aacttgatag atggatcacg 132300
taaacgtgca tgggctaatg caatatgatt tcggaagctt tctagttcat aatcactaga 132360
tttaaaacga gaagcactcc tcataccacc gatagctcct ttgccgaagt ttgaaccaat 132420
ctgaataacg ccagagttca ttggtccttc tgctttatat accggaactt tagattcaaa 132480
ctcttgatat ttcttagcag caaagctatc accctgaagt gaagcatcaa cagtagaata 132540
ttgagcttgt gctgctaatc gacgactaat tttagttttc tgaataacag cttgatccgt 132600
acgcttatca ttttctaaag caatagaagc agcaactgcg acagctttag gaacagcatt 132660
acctgtttta acgtctacat aaacatcacc gactttcgat tcaacttttg tgaataactc 132720
agttgaaata ggaggtacac ctggaatgtc ttctaaattg gcatttttac ggtaaaccat 132780
aatatatgca tatttcttat catagtccca gatttccttt aaaagaacat atcgacctgc 132840
tcctttagta cgtactaaac ggtcagcaat aacttgcatt tgacgagcag cgccatttgt 132900
tttacttttt agtacgcgga ataggcatgc atcaatttta tactgtttca ttgtttgaag 132960
agcagtatca aaaaccgcat taatgacacc aattggattt ccacccaaat ttttaagctt 133020
aactaacgat aatttctcat taacacctat cattacgata tgcatcattt tgtcgcctgg 133080
cttaacgttt ttattcgtat caccgccaga ggtgtatgta caaaatcgaa atccaggaag 133140
aacgctttct tcaccggctt gaatagcaaa aatttgaggt attttatgct taggatttaa 133200
gttaacaacc ggcgccgaag cgccgtcaaa taattctgta ataagttcca tgatttatcc 133260
ttgaacgaac ttgtaaggca tgtttgtaat atctatgcaa gacgcaataa ttccaagaga 133320
tgattctact ttctgtttaa catttgatga aacaaatgat gcaaagtcaa ctctatcttc 133380
tatttcaata tcacctgtca ttgcaactac ttcaccggtt tccattaaat ggtctccgtc 133440
atagattacc gattcggtga gctcttccgt ggtcataact tcagcttgaa tgagttttgt 133500
attattagat gttgttccgt cattattaga agcatcagtt attttattaa ctttgaccat 133560
caatccacgc ggtagaataa cttcagcttc tgttgctatt ccgagacttc ctggatatac 133620
aacattaact ttatgagctc catcaattgc ccatcctatt tgaactttaa cgtattcagg 133680
attttcttta tacgctctta tttcgtttgg attaatagtt attccttctt catttttatc 133740
aactgttaat tcattgcgag cttctggttc taaaagacca ataccagcat gtgtgattcc 133800
aaaacgtcca aaaatgatag gagttaaaga agtagataca aaatttctga agtagaacac 133860
tttattttta actaacgctt catatatagg agcagtcata ctttgagcac gataaactgt 133920
aatgccttct ggtatacggt caccattttc aaaagctgaa tctaagttat ttatagcaga 133980
ttcaatttct ttttcactca ttacatcata tcgttctgga ttgtaacgac ctaaaagaag 134040
attattgatg tcagtatatc ctgaaccgca atattctcta atgccacgct tttgtgatgg 134100
agtatattta gaaccatcgc gggcaatagt aatatcaatc attggaccag caccaattcc 134160
agaaaaactg taaatcattc gtttgaggaa tttagttttt gctgcgttcc aggaattttt 134220
agttatttct tcccagactt catctggttg tcctttacga tttttattat gattagcaag 134280
ccatttatct ttataatctt caaagaattg atttacagct gctgcgtatt tctctaaaca 134340
ttttattgaa gtagttggtt catttttaat tgcattaaaa attacttctt taattttttc 134400
tgaaacttca ccgacttgac tcattggaaa gaatttataa tcatagtgaa gttcatctgc 134460
cgttccttca gcaataattt ttgctgcctt tgttttagaa gctaatgaat taattccaat 134520
tttcatttct tctgcttcgg gaattaaagg tgcagtagct ggtttattaa aattagctgc 134580
tgtagattca tacttctgga ataattcact ttcaaatcta gaagattcca atgactgact 134640
ttgtgcaatt gctctacggg aaattttaac tttaacgatt acggcttggt cagaacgttt 134700
atcattttct tgtgcaatag atgcagcaat tgcctcattt ttggttactt gagctccagt 134760
atctttattg atataaacat caccgacctt cgattcaact ttagtaaaaa gctcggtgct 134820
aatttctgga actcctggaa tgtcttctag tgatacattt ttacgatgta taagaatata 134880
tgcatacttt ttatcgtaat cccagagttc cttaagaagg acgtatctgc cacctgaacg 134940
actgcggatg agtctatcag caataagttg aatttgtcga gcttgaccgg cggttttaga 135000
cttaagaata cgaagcatgc aggcatcaat tttatattga cgcattgttt gcattgcaac 135060
agtaaaaact gaattgatat aattaatcgg gcttggacca agacctttta atttagcaat 135120
tgaaccttta gcagttaatg taaaaggaac aatgtgcatc attttatcgc ccatctttaa 135180
atcacgatta gtatcacctc cagatgtata ggtacataaa cgaaagcctg gttgttcaat 135240
tgcatcatca acatgaactg aaaaaatttg tggtattttc ttctttggat ttaagtttgt 135300
aatcggaaga gtagtatctt cgtcaaataa ttctgtaatg agttccatca tatcctctct 135360
agtgtttatt ctatttataa aattaaaggc ccgaaggcct ttaataatct attggtaata 135420
gagtacgata tatttcaaac tttggacctt tttcataagc atcaaaagtt tctgtgaatt 135480
tattataagc atatgcatct ataaattcaa tcatgatttg cgatacagaa gtagaaacat 135540
ctccaccttc tttttgagcc acgacaattg tttctaagta agctttcata aaccagttac 135600
ctcatgaaaa tcgccaaata catcttcgaa cgtattagct ttagttttat cttcacgtaa 135660
acgaatcgca attggaagaa ataatttaac gtaatcggtg cggccatcag attttaacca 135720
accgttgcat tcacactcta gaatttttcc aatataataa ttttggtttt ccataatgcg 135780
agtacggtca agttcatgcg attttacacc agctttatct tttaagcctg aaccagcatt 135840
tactttaatt tttccacact ctgactcaag aataaatcca cccgctttag tagggtcttt 135900
acggtgagga taaattccta caatttttaa atcaacatca attacttctt taaatttata 135960
aagatttttt gaacgagcat tttcccataa tccatcgata tttttgagaa taataccttc 136020
aagaccttgg tcaatatact ttttataaat taccttagct tcatctaggt tatttactac 136080
ctggttttca attaaaatta ctttatcata acctgatgtc atttgttcta gtttagaaaa 136140
acgtacatca tatttcaaac gaaatgcagg aagaccgtat atttctacca acgggacata 136200
atcccagacc tgaaacttca tgcattgtgc ttctttttca gaaatggttc cctttaaaga 136260
tttattagcg attccattag aagtagtacg tgattcagct acttcggcga attctttagc 136320
tttactaatt tcaggataag catcaaaaag aaaatctagg ccttctggtt ccttttcaac 136380
ttgctcatgg tataccaatt cgccatcaat taacacacct tctggatgaa tctggcgagc 136440
ttctgcagtc attttgatta actcttcctt gagaagatct aatcctagat attcattacc 136500
agctcgtgat aaaagacgaa catcatctaa ttcatcacct ctgacttcag caaagcaccg 136560
agctccatca gcttttaatt gggcaaaggc tggaaacttg atattcttac taatgccttt 136620
ttcatcataa gaacttgcca gcatttgagg ttgttcagga attaaacctg gccaaacttt 136680
gtttgcaata gatactgaag caccgcattc aaggtctcgc atcatcaccc gacgcaaaac 136740
ttcaacatca tcttttttac cgtcagcaat atatccagtt aattcctcaa ttgccgcatt 136800
tccggtcaat ttccgagtag ctaacgtgaa ttcaatgaag tcaagcatat cggtaagagt 136860
caacattcca aaactctggg tagcaatacc aggtttaggc catttcttga tataatactg 136920
taacccacga gaataagtca gacgatatac tcgtttaagc aattcattat ctttattctt 136980
ttcaagaatt gcttgcttct gcttagttga accaatagat gctatttcgt tcagaatttt 137040
aagaatcatt gttcatcctt tagagtttgg tttacagctc tattataaat caattcatca 137100
ttaagctcag gcaaagactt atgatatgta gttctaactt tatttccttg catccagtgc 137160
ttaacgtaaa tgaaaccttg ctctacacat tttttaaaaa ttcgttcgtc tttttgagct 137220
cggaattctg gattacatct aaaaaattga tttacgtgac cgtaatcacg tgtagtatta 137280
ccttcatttt cataaatagt gtgaataaca aacattagaa tgctccttgg aaaatattat 137340
caccactaat aggtctatta tacaaatact ctatgccacc aggtttaata tagttccatg 137400
tctgaaacgg atgtgtctga tatggatgat atagattata aggattaaat ccaggcgttc 137460
tccaggtagt gttccaagga aaagaatcgt ttttaaccat cttctcaatt aaatctttta 137520
tagctttttc actatcaaaa ctttctttat tttccttcgg cgaaaaaagc ttattttcta 137580
catcattcca tgtataaact cgctgcgcag tttttggaat attgtcacgc tctcctcgag 137640
ccatccaata aaccggaaca tttaatattt cactcgcgtg gtcgcagtgg tgagcaagat 137700
cgtcaatata acaaattacg ttatatttct cttttgcctt tttgaacaac tcttcttttg 137760
aagaatcatg accacacatc attacttctg agaaggcacc aggaaaaaga gcattcaaat 137820
taaattgacg attcagcaga gcgtcaatag aatcacccaa tgctgtaaca gctacaaaat 137880
tataatcttc ttttaatttg ttaattacac acagggcatc tttatatgga gacaagtaac 137940
gaataaaatc tgatcgattg tatttttcaa ttagcttgac accaagttct tcatcacaat 138000
taaagagttt acctggagaa ataaatttct catcttggat catttttaaa atatgttcta 138060
acggaagatt atatttctga gcaaaataag gaagacctga ttgccagctt aaacatactc 138120
catcaatatc agttaaaata gtaggcttca tagagagtct cttaataggt ttaacacatc 138180
aataaattca gcttcggtta gtattgtatc atcttttgtt agaccactag ccatgctatg 138240
cttcaaaact tttcctttcg aggctagtaa tgcatcacga aagcccttgt tttgaatcgc 138300
cgcttcaaaa tatgcatttg tgtacaactc tttccacgct ggtgagtatc ttgaaaacgg 138360
aactccaagc cagaagaggg tcccacggtc ctgagctcta gcataagacc ttccagcttg 138420
ttgggcggca agcccggata acccaaatac acgacgttgc tgttcaacat ttttcacctt 138480
acatccttgg agaaatcctt caagacctcc aaattggata ccatccataa caaaaggcca 138540
ttgggcgaaa ttacttaatg cacacgatgg ccatctaaaa ttacttctaa tctctaactc 138600
aggcattttc aatacttata atttcaacat cagcccaatg accatagcaa ggaagacgaa 138660
attcaactgg ccagttaggg tccttttcta atataataga cttaacttgt ggttcttcat 138720
gttcatcagt atatggattt ttatctgtta ctttatatgt gaccttaatg tactgaattc 138780
caaaaatctt attaattata ttcatactaa ttcctttaat ccgtaaatag gagataattc 138840
atcacccata cgaaggtctt catttccatc tacccaggaa acaatataag cctcttttat 138900
ttgaacacca ctccatttaa atggaggtag aaccttagaa attaatccag gtataccaac 138960
tccctttaat tcaacagttt gacctaaaaa gaatttcatc agaacctcat ctgaaagccg 139020
tgtgatttaa cattaccgcc gccaatatca gaaatattaa tttcacgcgc aattgaaggg 139080
tcaatgtcaa tttcacgatt aagtttagcg atagctaaag tatcacgccc atttactgta 139140
cggaattcta aaggacaaac cacatcaaca taatttttaa tcgattcact ggtaggttgc 139200
aaatgagcag gaaggtcttt aggcgcctta gagaaaacaa cttcacagaa atttttgcgg 139260
gtatcaaaat aagtagtcat aaacatagta ttttcctcag taaggggccg aagcccctgt 139320
tttattttaa atatcaaatt cgttaagaac tacatcaaag attgcttcaa gatgctcagg 139380
tttagctctg ttactcaaaa tatgacgaat ccaagtttta accagaagct tacgattagc 139440
gccattccag caaggatggg tccctaaatc gcgttgacga aaatcatcat ccagagcgat 139500
tttgaagttt gaaccttcca ttgtgattga aaccgtgatg ccattttcaa atcgcatata 139560
aacgtagtta ggagtcatat actgttcaat ttcgcatact gatccatttt gatgtttcca 139620
aaggcaaata gtatcaatag aacctgcaat accattagaa acatatttac gttcaaagtt 139680
gatgtagttc atttttattc tccgagatgt ttaattgcgg tacaggtata taatatcata 139740
tcctgtacca aagtaaacaa ttattttact actttccagt gcttcatgtc aagtttacca 139800
acttttttca tcttctcaat caaacgttcg gcacgttggc gagctgtaac ataataccat 139860
tcgcctaatt cattttgttc aatttttcca acgattactg tattcaattc ataaatccaa 139920
ccagtaaaga aattatgaac ttgaattgta aaggtgaaat ctgttcccat accttctgtt 139980
gtttctactt caataatatc accttcaact gccattaaga accacatagt ttcatcatat 140040
ttaccattga agcatttagt tttaactgca gcgttcagat taatcgtttt cattttattc 140100
tcctttgttt gtgtaagata atactatcac aaaggaacca tactgtaaac aactttgtgc 140160
aatctttgga aaataaaaaa aggactcccg aaggagtcct caacttatgc tttctgctta 140220
ccaaaacgag aagcatcatc tcgaagaacc gcacgtgctc ggcgcatgat cttctcaaca 140280
gtttgattga tacgagagtt cgacccacgc ttgtaaccag cgcgtttaga atcaccaact 140340
ttcttttcaa ctgctttctt tgctttaact tgttttgcca ttataaattc tcttttaaat 140400
gaaaatgcag gacttattgg cattgcctgc gcaagccctc aagggggaac ataggttttg 140460
tatatttacc gacaggataa ccataaacct cgtcaacata ccaccaagac ttacacagat 140520
aacacttttc tgacgcatga tagtaacatt caagaggtac accgtaaaac tgccggggtc 140580
ttaaaactat aatgattcgc aaatcattaa tcagacagtt cgacggctcc tcgattttag 140640
ctcacactaa ggcagtgaat ctccaataaa ttacttcagt gttaccacaa agtgacgaac 140700
tgcttttcgt gcagcagaag ccagaggctt agcatactta agttcatctt tttcctgaag 140760
ctcagcagct aatgcagttt gagcaggatt tagatgtttg aaataacgca ggatttcaag 140820
agcttcggct tcaacatcaa tagatgcgcc atagttttcg tgaccattat tccatgcgtt 140880
tcgttgcagt tcaagagcgt gttgtaattg tttaatcatt taaaaattct cgttagagat 140940
taaaactcgg tagtcacgtt cttctgaatt tcatcttctt tcgacagatc tctcagttgt 141000
agactaccac atagaattgt tcggttaact tattattccg acacccaatt catattatta 141060
tttatatcac ttataaagac acggaatagc tttatagtga caagtaacga atttttgttt 141120
aatttctttt ggctgcttaa gacccagagc tacaaaagga tgcggaacat ttcgaatttg 141180
accaactgga agagaagtca aatcaccaac ttcgcagaaa ccttcaggaa catcaggacc 141240
gacagagtga actacacaca gttcaggaac ttcaccttga acacgtttac cgataataag 141300
tcctgattct gtaacttctt catcaccggc ttgtgcgggt tcagaaacta aaataacata 141360
ttcaccgaca gcacgaattg gtagctgttg tacttcagac atcgtttttc ctttttgtta 141420
acagatgaat taataataac aaataattct taaagcattt atttaccaat aaattggagt 141480
aaatgctcaa ctttcatacc attaacagaa atcaatttgt caatagaaaa acctcgccat 141540
gcaccaagtt caacatcaaa tactggaatc atgtcagtag attctttccg agtcgattca 141600
gtcaatttac cagtttgcat ggttggcata aagtcagcat cgcgagtacc tttcatagta 141660
cgaatagtac catcagactt ttcaaaaact acgtttgaaa tacccatgga caatttagtt 141720
ttcaaaattt cacgaattgc tactttctgt tcagttgtca gtttcattta tttacctatt 141780
acagttttaa tatgagttct tccacgttct ttaagggtgg aaagtaattt ttggcatttt 141840
tctaaatcag atttccaact atatggtcta tcaatactag tccaatcagt tttataatac 141900
tgtttccatt tagagaaaaa atatttctta tactctacag caaacgagat gttctcgtta 141960
gaataagaac taattgctgt aagctttacc aaacgaaatt tcattattca ccacagaatt 142020
cgttgatatt ttcccagttt aacttattca agtttttctt aggaacatta aacacttcaa 142080
tacctgcatt tcgcagaata tcatcccagc caggtttatt tttatcgtat gtttcgcaat 142140
aaaccagttt tttaatacca gattgagcta tcgcttttgc acaatctgga caaggagaaa 142200
gtgttacata catagtagca ccttcaatag aagaaccatt tcgtgcagca aacaaaattg 142260
catttagttc agcatgaatt tcatttttag acgaccattc agagtgagca ctacgatgtt 142320
ctttagccaa gacaaagcga tcagttgaac caaatgatac gcattcaggt ttatggcctt 142380
gaatgatagt gtgtttaggc ttattcaaca accaaccttg ctcagcagca taatcacaac 142440
agttcacacc accagcaggt gaaccattat atccggtaga aataatacgt ccattctttt 142500
caattactgc tcctaccttc caggagcaac attttgattc ctgcgatact aaatatgcaa 142560
tttgaagtac tgtactcgct ttcatttcat aatcaccaga taagcagatt tagcagtttc 142620
aacacgataa atttcgtgac gaagtttagt tatactttta ataacagaac taattatatt 142680
ctgcccatct ttaaagcggt ttttcttatc aataaaaact gcgccagtca tctttttgtg 142740
aagctcaact ggatacttcg tcacaataat agcatcatat acagaaggat gaatactatt 142800
tactagagtg tcattcatta aagttattct aatgaactgt gctgtttcag agtcaagcgc 142860
tctatgatcg ccagtatcat tttcaagaca attatcaatt atatcagtta aattcatcat 142920
agtacgccat acaccctttg tgcttcaact aatccatcaa aatctaattt aagatgcgat 142980
atttgatcgc catcacctgg attcacaatt actaatactg aacgaggagt ttcagtaata 143040
acacgaaccg atgtttcagg aaatcgttca gaaaccttat ttaccaattc ctgcgcaaat 143100
agcttaactt tttcttggaa ttctttaaca gtaatcggtt tttcacttag cagcattttg 143160
ttttcctcat ttgtttggta gagctataat atcacaactc taccgtaaag taaactatta 143220
aattgctttg aattctgatg tctgtgattc aaaacgaatg tcgcctttga taactagctc 143280
agcatcaaga ccgaatacaa caatgatatg cgcggaacct ggatacaacg tgatggcaac 143340
agaatccacc tggtctggaa gcaaagtgtt caatacatga gtcacttgag catgaattcg 143400
aagctcggct gcgttatcaa gcttttcaaa catattatta gcgataattt gactaaacac 143460
tacttctaca attttagaat aagtcggaaa catatttacc tcacataatt ttcttcgagc 143520
caatcaataa catccaacgc attatcaaaa gttgaaccat ctactttgtc ttctgtttca 143580
taatcaagaa catctaaacc tactcttcca tcaacaatag gccataaaca aaatagatat 143640
ttcttttctt tttcaatttt atcacaaaga cgataaatct tttctatgtt attcataagt 143700
tttccatggt aaaggcagtt tagttttctt tactgttagt tcaacatcag gattcttttc 143760
tcttaattta aggcattcct cccaagctct gatttcacta gtgaatacac aaaattgccc 143820
attactagta ccgactaaac cactatttac aataataata gcccaagttt catgatgcaa 143880
cgccattaaa aatctcccga agcaacttgc cagcattcaa caccgatacg acgccacatc 143940
tcaactactt gagttcggtc atcaatagct aatttcacgt caaaatgtgg tgcgatgtgt 144000
ttccagaaaa tttcttcttt aactacatca tctttacggg tatcgccttg ttcgcgttga 144060
cattgcataa ctaatggaac accagcaatg tcctcaaccc atttacgggt catacgataa 144120
tattttgttg ggtcttcttc ggttccactt tcacggcccg aaacaactac gatgtaatat 144180
ccttgcttat cgtacatctt agctagttca acgaccattg gattaataat atcggtatca 144240
catttttcaa ggtcataagg accacgacca ttcatttttg ctaatgtgcc atcaacatca 144300
aaaataactg cttttggttt accaggagtc cctttatata ccggaagtcc gagatattcc 144360
cgcatgcttt tatacattga acgtaaaaca tcaattggta ctgctttagt tccacgtttt 144420
gagttacgtt taactaattc aacccatgga acatcgaaca cttgatattc gacttggtgt 144480
ccccactgct tagcatattc ttcccaggca agacgacgtt caggattcag attagtatct 144540
gaaacaatta cacccttcgt tccgtcttgg cagagaatca tatgtgccgc atcgtgttgc 144600
atataagtca cgatgctttc tttcttcttg gtgtatttgt actcatcacg ttcttcgtgt 144660
gccataacag actggcgata atcatcacga ttaatattat aaaacccagg attcttagca 144720
ataaattcac gagcccaagt gcttttacca gaaccaggac aacctacagt caaaataatc 144780
tttttcatca tttaattcct aagaaaactt caagaatacg aatattatgc tcacgccgtc 144840
ctttgtataa ttcagctgtt gattgattcg ctgatttact ctgaacattg gatgaaataa 144900
attttatcat gtgattttta agctgataca tatcaagccc acgagctttc gcttcttttc 144960
gcagggcttt acccgcatca tctaaagctt tagcgtgttc aatgtcttcg ctaatacttg 145020
atacattttc actgcatgca tcaatgtaac ggtctgaaca ttcaatataa cgttctaaca 145080
gagttttcat ttatttttct caaccaatga ttgaatataa tcatgcaggt ctttagatgc 145140
tttaccccac ttattttgat attcattttt gagattagcg cgtgattgag ctaataaaac 145200
atcattagtt ggaggtaaag attctaatcg ttgaatctgt cgtccataaa tcattgcagc 145260
catctcggat tcataaatta atccttttag atgttcaaat tgataccatg aaatcattta 145320
catttatcct cttttagctc ttgacgataa taacatatca tagttttctg gtcatgtaca 145380
tatcgtttta catcattaag ccaaatacga aattcctgag aatcttcaaa tggcatacct 145440
acccaagctt taccatcaat aactttaact tgccaagata gtttagcttc gtcatatgac 145500
tttatttgca caggccaatt aggatgaact gtttctttct ttacttctag aggctttgtc 145560
gaacaaccaa ctagaagacc aatagataat attactgcag ataatttaat catttagaaa 145620
ggtcctggat gtcttctgcg aacttgttga aggagttgtt gatttgtttt tcaaccaatc 145680
ctggcttacg agccaccaca tccgccttct ttgcatcttt gcgcagtttt tcattttcac 145740
gctcaatagc agcaatcgcc tcacgatttt tattattcat cgcatcaata taattatact 145800
gaattcgcaa attatttaat gctaaggcgt tttcattggc cgtttttgta atttctacaa 145860
cagacgtttc taatctttct accttatttt ttaaaataat agatgttccg ccaaatgcta 145920
ttacaagtaa tagcaatcca gctgtaaaat tacttacatg cataaagttt taataacctc 145980
tataatatcg tcttgagaaa gaccgttaat taaaatatga tgttcagccg gagatttaga 146040
aattttaaag cacgccgcaa catcttctgc catatccgat gcgctacgat ttggattact 146100
aattccaaga cgatgctttc ctgtcaaagg attaacgatg atatagcatt tgcagctatt 146160
gatatgaaca ttaggttgag tctgattaat aaacacttca caatcatact tagcgagttg 146220
attttctaaa aagactttca tctcctcaac cgcatcagga agcatatcac gggcttgctc 146280
aagacgacga tttcgatatt ctttaatggt cgttttccgc ttgacttgct tagctaaatc 146340
tttcttaaga tcggtgatat atccaactcg acgatttcct ttgaatacag aaatcccatc 146400
tgtagtatca ccgtatgctt caacgaccat ttcagtagta ataagctgca aatccatcat 146460
aaagtcctca tgttatgtca gtaagactac tataacacaa cacgagggac ttgtaaacag 146520
cttagtatcc ttctgggata aattttttat aatttttcaa aaaattctgt tcgatttcgc 146580
acatgacctt ttcttgacta tcgtacccct gatataggct cataatgata ccgaacaggt 146640
gatccattcc agcaccttta gcaacacctt gcgcttccat cgcataagtc tttctatcct 146700
taccacaatg cttattatga cagtcaagaa ctaaaaacag agctcggtct aagtacttca 146760
gataagtcgt ttcaaatgct tcaatttttc tgtatgaata ttcatcgtca gcatacattg 146820
ctttaagatc atctgatgca ccatcaataa tagtcttaaa caatttttct ggattatcta 146880
atgaactttt tgtgctatga agagacacat accagtcaga cttaatttta aaatgagaac 146940
catctttcat cacagcaaca tagccttcga tgttttccgc atttttagct tcttctaccc 147000
atttagggct atcgatttcg tatcgttcaa ctagatatgg acgaagagca gcatctttat 147060
aaatatcatc atatgaaatg tattcgcctg tttcattttc acgaatattc aataaaatga 147120
ttttcatctc ttgataagca agaacgattc tattagttgg agcgacgaat tcgaagttag 147180
cagtaaatcc atcttcagct aattctttaa gtctatcacg caaccgatgg tgattaatat 147240
tcatcaaaat accattagcc attaaagcct gttcggattt gattgaaccc tttgatttga 147300
acagaatttc atcaccgtct aaataagttg ataccaaaga cccatcttcc tttgtcagaa 147360
tgtaatcaac atcatttaaa tcgatattca tcgtgaatgg attttcgttc aagttaaaaa 147420
acttttccat gggacgagag gcaattctta ctggtttttc tccatccatt tcaaacatga 147480
ttccacgaca ttccaatgcg tctggaagta accaatcaga ataagatgca taattatatg 147540
agaaaattct gtaagttctt ccagatgcac ttacatcatc cgagtaaaaa aacttacgct 147600
gtgaatcctt acatagttcc attaaattgt taaaaagttc ttgcattgtg tatcctcttt 147660
tgtattttga atatagtacc acattccatg tggaagcatc attttttctt atgttgaata 147720
ttccaaggcg ggttaaacag tttaatgaat agtggctcct ctaggtcaat cgttgcgatt 147780
gtcattgtac ctaactcatt tgtcatagaa agattaaaac attggcgggc gtaaaattca 147840
actttgcttc cttcctttag cgcagcatga attaatgcag atttagtaga gtcagacgtt 147900
ttgtctttac gattaatagc agttctataa taatttattc ttttacgtaa atttttagtt 147960
tttccaatat aaacaagctc atcatttata gcaatagcat aaattacgtt atacttattt 148020
ggaatagata gttgttttat acttccgttg tcgtctaatt ctaactcagt atatttaata 148080
aatgaatatt ctgttgcaat ttctttcata ataaaatggg ccttgcggcc cactccttaa 148140
aagtattttt taaaactcat cataacttta tcatcaacat cattatcaat ctgtgcaaca 148200
agataagatg acagttctac ttcttgcggc gcggattgaa cattatcaga attaaggtat 148260
tcacgaatcc aaggatatgg atgtttaacc ggagcatcgg taatcgggca tggaagacca 148320
cactgtttca tacgagatac agttaagtaa tcaataaagc tccacatgct atttgtattt 148380
aatccaggaa catcgccatc tttaaataaa tgaactgccc aatctttttc ttggcggtta 148440
acttccatga aaatatcaac tgcttcttgt tcacactctt tggcaatttt aacccattca 148500
tcgccatcag taccagattg aagttgacga ataatatatt gtgtaccttt aagatgaagc 148560
tgctcatcac gtgcaataaa tttcataatc ttcgcattac cttccatgat ttccatgttc 148620
ttatggaagt tgaaagtaca tgcaaaggat acataaaaac gaatagcttc caatgcgttg 148680
attacatgca gacaaaggta aagagaacgc attagttcgt atttgcattc ttctacatgc 148740
ataaggctat ttgaatatgc gtccaaatca tattcattct ctgaaaaaca cctaaaaatt 148800
tcttttgcgt tttcccattc acgagttttc tcaataacat catcataata acgaccaata 148860
gattcagcac gtttcatgat agctttatct aatacaatct catcaaatac ctttgacgga 148920
tcagtataaa gatttcgcat gatatgagta tatgaacgac tgtgaatagt ttcactaaaa 148980
gtccatgtag caacccatgt atcaaggctt ggatctgaaa ttaatgacat aagtacagca 149040
gacggtgcac gaccctgaat gctatctaaa agtgattgat acttcaggtt attagtaaaa 149100
atatcttgct gatactgggg aagcttgtta aattgtgcag catccatcat caagtttact 149160
tcttcaggac gccagaaaaa actgatctgc cgctcaatga gttcttcaaa tactcgatgt 149220
cgttgaatat catatcgagc taaacctaat ccagaaccaa agaacattgg ttcgttcaaa 149280
acatcgactt gttgtgtatt aaaaactgta ctcatttaga atccttaaat ttacatttat 149340
cataatgcca tcttagagca ttgcctttat taactttctt gccacaatgc ggacaaggtg 149400
gatattcagt actttgctta gttctcaaag aaatcaaatc acgagtttct ttagtatgag 149460
gaacatctct tgttggagat attgtaccat acataggatt aagcacgccg actttagcag 149520
cagctatatt ctttttagct tcttcagttt taggctttct catctttttc ttagtttctt 149580
cgcttttagc ccttcctttg gttgccgccg atattttgtg tttggtttct tctgttaaac 149640
gcagacctgt tttcgctttt gacattttca gtctcgtttc ttcagaaatg accgtacctt 149700
tgcgaaattg tgaatttaac ttctttgcat gggcatatat tttagaatga actttataat 149760
gacgtttctt agttcctttc atattgcaca tcatgaaaaa tgcgaatata acagatttta 149820
ccggataaat ctttgataaa atagcatgcg ctataaaatg ttctctagct gttaattcaa 149880
ctaaattttc tttatcatca gaacctccca tgcatctagg aactatatga tgtgtctctt 149940
tatattcaga taaaggttcc cgagcctgag ctcgggaaat taggtcgtta tagatttttt 150000
gataattcat tacaatttac acgctgcaca atcttcagct ttaggtgttt ctaattcata 150060
gtcatctgta cctgacccat cacgagtgtt atgatagtag aggttttttc cgccaaagta 150120
ccagaagtaa agtagatcgt caagcattac tgacattggt actttacctt tctcaaatac 150180
cgcagggtca taatatgtat tcgctgaagc tgattgacat acccatttca gcataatagc 150240
tacttgcgta agataaggct tattaccttt cttagctaat ttccacgtat aatcatacag 150300
gtctatgtta tgctcaatat tgggcacgac ttgattaaag gagccctctt ttgattcttt 150360
aacagagact ggtccacgtg gaggctcgat accgtttgta ctgttagaaa cttgggaaga 150420
tgactcacat ggcataagtg ctgataatgt gctattacgg atgccaaaga gcttaaggtc 150480
ttcccgcagc gacgaccagt cacaaacgta ttttggagct gcgatttggt caatcttttt 150540
attgtaccag tcgataggta attcgcctcg agaccaacga gtgtctgaat aatattcgca 150600
aggtcctttt tctttggcga gtttaatgga tgctttaatg agtccatact gtaatctctc 150660
aaatagttca tgtgttaaat cgttagcatc ttcataagaa gcaaagttac ttgccaacca 150720
agctgcatag ttagtaacac ctacaccgag gttacgacgc tttttagctt tttctgcttc 150780
aggaactggg tatccttggt aatccaaaag attatcaaga gcacgaacct ggacttctgc 150840
caattcatta attttatctt ggtcttgcca gtcaaaatta tctaatacga atgcagagag 150900
agtacacaat ccaatttcag catcaggact attcacatca tttgttggaa tagcaatttc 150960
acagcacaag ttactctgac gaataggtgc cttttcacga ataaacggag tatagttatt 151020
cgtattatca atgaactgta cataaatcct tgctgttcct gagcgttcag tcatgagcaa 151080
ttcaaatagt tcacgagctt taatacgctt tttacgaata ttagggtctt tttctgcggc 151140
ttcatacaat tcacggaaac ggtcttggtc tttaaaataa gaataataaa gctctccgcc 151200
catttcatgg ggactgaaca aagtaatgta atcgttcttt ccaaaacgtt ccatcatcaa 151260
atcattcagt tgaacaccat aatccatatg acgaatgcgg ttttcttcta cgcctttgtt 151320
atttttcaaa acaagaagat tttcaacttc caaatgccaa ataggataat aagcagtagc 151380
agcgccgcca cgaattccac cctgtgagca tgatttaaca gcagtctgaa aatgtttcca 151440
aaaaggaata acaccagtat ggcgtacttc acccatgcca atcttagaac cttcagcacg 151500
aatcatacca acgttaatac caattccagc acgtttagag atatattcaa caattgaagc 151560
ggaagcctta ttgatagact ttaatgaatc acctgcctca ataacaacgc atgaactaaa 151620
ctgccgagtt ggagtacggc aaccagccat aataggagtt ggtaatgaaa tctgtcgagt 151680
agatactgct tcataaaaac ggataacgtg ttttaatcta tcaacaggtt catcttgatg 151740
caatgccatt ccaatagtca taaatgcaaa ctgtggagtt tcataaattt gaccagtggt 151800
tttatcttta actagatatt tttcttttaa ttgcatcgcc ccggaataag taaattccat 151860
atcccgctcg tgcttaattt ttgattctaa aaatgtaatt tcttctgcag aatattttga 151920
caacaattca gggtcgtatt taccttcatt tacacagtaa gaaatatggt caataaatga 151980
acgtggttca tactgcccat aaacatgctt acgaagagca aacattaaac agcgtgcagc 152040
tacatattga taatcaggtt cttcaaccga aatagaattc gcagcggcct taatgacaat 152100
agtctgaata tcatcagttg tcattccatc acggagataa gatttaatat tttcatataa 152160
ttcataagga tctactgatg ttccttcagc tgcccaagat aaaactttaa taattttttg 152220
tgggtcaaag ctctgagaaa caccactact tttgataaca ttaattaatt gcataagtcc 152280
tcaacttgaa aatcgtcttt aaacaatcgg ttaactatat gagctattat atcaccatga 152340
cacggctttg gtttacatgt gcatcctagc ctcattccac gtaaaggctc taaatgtgct 152400
ttagttattt ctccggattt aattcgacgt ataaaatctt ttttgaataa ttcaatggca 152460
gcctcccggc tgccagcatc tttaccgacg taatttcccc aaaatgtacc acggtgaata 152520
ttaacatcaa agtcggattt atatttattc actactcggc atatacggcc tgcgcggttg 152580
taagtgttca tattgttctt ccgttaaaac agtaatatcg tagtaacagt cagaagaagt 152640
tttaactgtg gaaattttat tatcaaaata ctcacgagtc attttatgag tataatattt 152700
tttaccataa atgataatag gctgatttgg tcctggaact tctagctcac ttggattagg 152760
aagtgtaaaa agaactgcac cagaagtatc tttaaatcgt aaaatcatat atcctcgcaa 152820
ttaaattgaa attacaccgc catctttcct ttaattggcg ggtgagatac atagttgtta 152880
agaacaaaat tatgcggctt tgcgaattga ctcaaccaaa atacctgtga ttctgtaccc 152940
cattcatcga attcatctgg aaattttaat tgcaattcgc ataaatccat aggttcacga 153000
cgcaaaattt ctttacattg ttctacgtga ttcatataga tatgagtatt accaccagaa 153060
aatatcaaat ctcccggaat aagattacac atcttagcta caatatgaac taacgtagca 153120
tatgatgcaa tattaaatgg aagcattatg ttcagataag gtcgttaatc ttaccccgga 153180
attatatcca gctgcatgtc accatgcaga tcagactata tctccaactt gttaaagcaa 153240
gttgtctatc gtttcgagtc acttgaccct actccccaaa gggatagtcg ttaggcattt 153300
atgtagaacc aattccattt atcagatttt acacgataag taactaatcc agacgaaatt 153360
ttaaaatgtc tagctgcatc tgctgcacaa tcaaaaataa ccccatcaca tgaaatcttt 153420
ttaatattac taggcttttt acctttcatc ttttctgata ttttagattt agttatgtct 153480
gaatgcttat gattaaagaa tgaattattt tcacctgaac gatttctgca tttactacaa 153540
gtataagcag aagtttgtat gcgaacaccg cacttacaaa acttatgggt ttctggattc 153600
caacgcccgt ttttacttcc gggtttactg taaagagctt tccgaccatc aggtccaagt 153660
ttaagcatct tagctttaac agtttcagaa cgtttcttaa taatttcttc ttttaatgga 153720
tgcgtagaac atgtatcacc aaacgttgca tcagcaatat tgtatccatt aattttagaa 153780
ttaagctctt taatccaaaa attttctcgt tcaataatca aatctttctc atatggaatt 153840
tcttccaaaa tagaacattc aaacacatta ccatgtttgt taaaagacct ctgaagcttt 153900
atagaagaat ggcatccttt ttctaaatct ttaaaatgcc tcttccatct cttttcaaaa 153960
tctttagcac ttcctacata tactttattg tttaaagtat ttttaatctg ataaattccg 154020
cttttcataa atacctcttt aaatatagaa gtatttatta aagggcagtc ctacaattta 154080
gcacgggatt gtctactaga gaggttcccc gtttagatag attacaagta taagtcacct 154140
tatactcagg cctcaattaa cccaagaaaa catctactga tcgttgatac cactgcaaat 154200
ccaaatagcc attacgcaca ttaaactgat agaacatatg acagggcggt aatgccattt 154260
gattgatttc agctggattc catgcagaaa caatttgacg cctatcattt ggcagttttt 154320
taatacgatc aataacttct ataatttgat ctacaccgcc aaaatcacgc cactgttttc 154380
cataaattgg accaagttca ccgctatggt atcctaaatc ttttgcttga ttttcgtaat 154440
tttcatccca gactgttttg ccttgaatta atgaatcgtg ctgaattaat cgtaaatcat 154500
tgacatttgt gcttcctgat aaaaaccaaa gcagctcagc aatgcaagct ttccaggcga 154560
gcttcttagt tgttaccgca ggaaaacctt tagttaaatc ccagcgtaat ttagtaccaa 154620
acaaagcaat tgttcctgtg cctgttcggt catcggtttc atagccattt tcaaaaatgt 154680
ctttaattaa atcttggtat tgtttcattt agtaccttat ataaattata atacatttta 154740
tgaagctaaa taatcaatac ggtttagcat caaattttct ctcaatttca ggcgtgaaat 154800
ataattcttt accgcgtttg gaaaagcgac caataatatg ataattattc tcatcaaacg 154860
tgatattacc aatatccata gctttcaacc aaatatcgat atttctatcc agctttatgt 154920
caaaattcca atacggagaa ctattaccga aaatactaca agcggattca gtgaaacaac 154980
tgctataaat cttgtcttta ggaactacta attgatagac acctttaata aactgaggac 155040
cctgccactt tggctgtttc tcatcttttt ctaatagaat agggtaataa ttaaaattca 155100
tatttccgcc gcgcgttatt tcatttatat actgattccg taagggttgt tacttcatct 155160
attttatacc aatgcgtttc aaccatttca cgcttgctta tatcatcaag aaaacttacg 155220
tctaactgaa ccgttgaatt aacacgatgc cttttaacga tgcgggaaac aactacttca 155280
tctgcataag gtaatgcagc atatagtaga gcgggtcctc caattacact tactttggaa 155340
ttctgatcaa gcatagtctc gaatggtgca ttagggcttg acacttgaat ttcgccacca 155400
gaaatgtaag ttatatattg cgcccaagta atatagaaat gtgctaaatc accgtcttta 155460
gttacaggat aatcacgctc aaggtcacac accacaatat ggctacgacc gggaagtaat 155520
gtagataatg actggaacgt tttagcaccc ataatcataa ttgtaccttc ggtacgagct 155580
ttaaaattct ggaggtcctt tttaactcgt ccccatggta aaccatcacc taaaccaaat 155640
gctaattcat taaagccttc aactgtttta gttggagaat aagcgaatac caatttaatc 155700
attacacaaa tcctctttcg ataaaccatt cagtggcttt attagcatca aagaataatt 155760
cttcatatgt cttttctttg ttttcaaaaa ctgtcacaca aacacgttga cattctccac 155820
agtattcttc tgacatactt aaagcgtcag aaaacatttc tttaaattca tttaaatcag 155880
gattatgcaa tgcgttaaaa attgcataat cgaattcatc attcataaat tcaaatacaa 155940
aaatcatatt acctcccact gaaaggggcc agaagcaaat ccgctatctt taatcatttt 156000
aactaaagtt accattcctc tgttaactgc ttgcgagatt tcatcaaaaa cttcatcact 156060
atcaccataa agatcgctaa aaagttctaa cacgttcttc tgaactttta atttacagcc 156120
aacaaattcg cctacagtaa attcgtttcc gccaactcca gcgtaaaacg taattacacc 156180
agttaatggt ctttcactag aacataggtc gtgtgataaa ttaatataag ccgtcccggg 156240
tgcagtttta agttggcaac gaatacttac tcgagcaatt ccagctacac gaatgtcaga 156300
catattattt tcctcaaata gactttttca caattttcca atcagcttta aactgctcga 156360
cgtcagaatg gtaaatccaa aatcctgcgc tttctccatc ctcataaaga gggcatccat 156420
cacattcatc ttcccatccc atatcgcgta aaaggtgttc agctttttca acaagttcag 156480
aatctttacc gatgatatta aaataccatt tacctctaac ttctgaatct ttgatactct 156540
gacgttgtaa tctcatttta ttctccttag caagctttaa tcaaaagata taaacagacc 156600
aacataactg ctgccataat ataaggtgcg aacattttct tttctccatt agttttgata 156660
gggtaatagt atcacactac taccccgttg taaacaatta tttttgaatt ttatcgagcc 156720
acttaccaag cttaatcatt tctttagtag ccttttccat acttctgaac ttaaccaata 156780
gaggataggt atcgacaccc ataactaaac tggttacaag actgtgttca cccacaagcc 156840
ataacgaata cgtttgaata tcgagtccgt aatttctgtc tttatggacc cgtacaccca 156900
tcacttcaaa tttctcacta gctttttcta ccgcatccag gaaatcatct ttagtcatat 156960
taggccttaa aagtttttcg caaaagttca atgatttcat ctacattgtt ttcgtcaaca 157020
atgcagtgaa tttttgttac gccagaaact ataccttcat tagcggattg aggcttttct 157080
aaagttacct cagtaaagta tttgaattct tcagggtaaa tctcaaaata cgtctcaagt 157140
gggccacccg ccatgtattc agtgccgtct tccatagtta cacgtaccac acagtcacca 157200
gcacaatcat cactttccat ttcatctaca acaaaactag gtccgtgctt ctctattaaa 157260
tttagcatca ttacattgca acggcactcg ttagcaaagt catttttaaa taaagggtta 157320
atgatataag tttttccaac ttccactttg atttcctcat tttaacgggg ctatcaaata 157380
gccccttgat aattattgtt caatcagtcc catgtaaaat tctgcgtctt cagaatccat 157440
gccatcgcaa tattcattag ccataaagcg ggtaaggtct tcaagaggac cttcaatgac 157500
aatagaaaaa ttgcaataat tgggatcatc atgaatactt gtgatactaa gttcaggata 157560
acgattacga ataatctctt caatatattc aaaatcaacg atgtcaatat caactttagc 157620
catattattt tcctctttaa tcatcagcag tattgccgat agttgtatag taccataaag 157680
ccttatgttt gtaaaccgtt ttgtgaaaaa atttttgaaa taaaaaaagg ggacctctag 157740
ggtccccaat taattagtaa tataatctat taaaggtcat tcaaaaggtc atccaggtcc 157800
gtgtcatcag cactagatga actgccagag cttgagctca taaaatcatc ttcagttttt 157860
gtattgaagt catcaacatt gaatgcatcc aaatcatcag caactttatc agctttctta 157920
gcagcagttg cagcggcacc gccaatcaca gcagttccca taacttgacc gaatttagta 157980
ttcagttctt caaacgattt gaatttatct ttagaagtca tttcagaaag gtcaaccatt 158040
tgttcgaaca gttctttctg gaaagattca tcgtcaatgt ttggaatcgc agattgattc 158100
aggaatttag attcgtcgta gttactaaaa ccagaaactt gtttaacttt cagtacaaag 158160
ttagcacctt cccacggaca agttacatca accggagttt cacccatttc aacatcaact 158220
gcaatcattg cattgatttt atcccagatt ttcttaccga aacggtattt aaatacttta 158280
ccttcatttt ctggagcagc tgggtctttt actacaagaa tgttagccca gtaagaagtt 158340
ttacgtttaa caagaccgta ctctttattg tcagtgttgt ataaatcatt tttattgatg 158400
tactgacata ctgggcaaga atcgtaatca ccgtgggtag atgaacagtt ttcaatatac 158460
catttaccat ttttcttgaa accgtgattt acaagaattg tgaatggtgc ttgttcatca 158520
tttttagacg gaagaaaacg aattactgct tgaccgttac ctgcattgtc gagtttcagt 158580
ttccactcgc ctttatcttc agaagaaaaa ccacctttat ttccagccag tttagccatt 158640
tgtgcagcga gttcagcagt agatttacgt ttaaacattt ttatttcctt tttaatttaa 158700
ttaacagttg gtgctatgac gatgtatgac ctcatagctg gtcagtgaga taattataat 158760
ctatttataa taagcaatta atacttacaa gatttcacag tttcaataaa aactttttta 158820
gcttcctgtg aatcgatatt taaaattttt ctataagcct ttaactttat agaataatta 158880
ttccagacta aattatcagt ctgttcatca tgtttatcga ttatatttaa aaacgaatca 158940
agcaagataa acgtctcaaa cgaaattata ttcgattgca gaagtttaaa aatataactt 159000
gactgaactt ttggattata ctcaaagatt tctttaaaag cagaaacttc aactttttta 159060
ctaaaataat aaatgttgcg aatatcttct tcaaacttaa atttaatttg ctttaagcgt 159120
ccgatatatt cacgataaaa cacaagtgca tcagcgtcag agatgtcgcc aatccaagcg 159180
tcttggttag caaccaaatt acttataaag attaaagcaa gttcctttaa tttatatttt 159240
tctgataact tctggaaaaa atacttatcc cttcgctttt gataagcggc atcagacacc 159300
cgcatgcacc aattatactt aataacatca tactttccat tcatatgttg ttttatcatt 159360
aagtataatt tataaactga tttaccatca atgtatcttt caccaccagc aggcatgcgg 159420
agtttaatca tagcagaaaa tctaatgtat tagttttttc acaacgaaca acagaaggac 159480
gtaaaagatt ttcgtcaata gcttctgact gaattttttc aattataccc gaaggaataa 159540
atttagcaaa ttgagtttca ggaatagaat tttcttctaa gaatgctgtt gtagcttcaa 159600
gataactcat tccaaactct tctaccattt tttcaatgat aaatccattt tcttgtcgat 159660
caagaagctt tgcgatttca tctttttcct ttttaaggga aagttctttt tctgaaagcc 159720
cggcctcatc gaccggacga atatcattta gagaaaactg tgtcataaag ttcaactacc 159780
tcttcagttt cagcttcaaa cacatcacgg ttatctttat gatatagagc caaaagacga 159840
ttaaacatct tgccatcaac accaagttca tctttggcac gaattcgaat atctttaatc 159900
aattcattat aaccggaaat tttcagttta tgatcagatg cttctttaat aaatttagcc 159960
aagtcttcgc cgtggatagc ttcatcaaat tcaaccattt cttttttagc cattattcac 160020
ctcaaaattc attaatgcta ttagttaatt tagaaagacc cgcttttaca aaatatgaat 160080
aaattttgcc acgcggtggt aatttatatg aattatagta attcacaatg tttgaagcaa 160140
tattatcagg aatataatca aaatcaatta gaactaaatt ttctttataa cgattatatt 160200
cagattctgt gagaagcacc ttagcttgct cacggtcatt agcaatagct tcaacgattg 160260
aagttttcat tgaaggagtt cgttcacctt caactttggt aaaccaaaag tcagatcgta 160320
ctttaactga agcaacgtta tcctttttgt cgcctttaag gattttagtc atacagtcaa 160380
tttcagcaga accgctttta attttaaccc atttcttatg catcggtgac cattgcttaa 160440
catttgggta tttgtgaagc tgtgtaaagt caccatccga cgaaatgatt aaaattttat 160500
gtccttctaa agagaacttt ttaacaagaa cagcaatgtg gtcatctgct tcatacttat 160560
caatatccat aacaatgtat ggcatataag ctttcaattc atctataact ttatgactgg 160620
attcaaaata accttcccag tcccaagtag attcttctcg tgcttttccg cggtttttct 160680
tataataata cgcgaaatca cgacgccagt atccagattt cgcgttatca atacacagta 160740
caattttagt gtatccaagc gtttttgctt ttttaacatt aaacttaatt gagttcaata 160800
tcaaatgacg aaccattgat aaattaattt tttctttatc tgggaagttt accaaagcag 160860
ttgaaagcgc aatttgacta aagtcaatta agcagattcc ttctttgtaa tcttcatcca 160920
acatcatttc taaatccata tgaacctcgt tcaattagtg agatttctat tatataccat 160980
ccgaatctta aagtaaacaa gtataaatac ttattattga aaacacaata ggagcccggg 161040
agaatggccg agattaaaag aaagttcaga gcagaagatg gtctggacgc aggtggtgat 161100
aaaataatca acgtagcttt agctgatcgt gccgtaggaa ctgacggtgt taacgttgat 161160
tacttaattc aagaaaacac agttcaacaa tatgatccaa ctcgtggata tttaaaagat 161220
tttgtaatca tttatgataa ccgcttttgg gctgctataa atgatattcc aaaaccagca 161280
ggagctttta atagcgtacg atggagagcg ttacgcactg atgcaaactg gacaactgtt 161340
tcgtcaggac cttatcaatt aaaatcaggc gaatcgattt cagttaacac cgcagcgggt 161400
aatgacatta catttacttt gccatcttct ccaattgatg gtgatactat cgttctccaa 161460
gatattggag gaaaacctgg agttaaccag gttttaatta cagctccggt acaaagcatt 161520
gtaaacttta gaggtcaaca agtacgctca gtactaatga ctcatccaaa atcacagata 161580
gttttaattt ttagtaatcg tctgtggcaa atgtatgttg ctgattatag cagagaagcg 161640
gcagttgtaa caccagcaag tctttatcaa gcgcaatcaa acgattttat cgtgcgtaga 161700
tttacttctg cttcagcaat taatattaaa cttcctagat ttgctaatca tggggatatt 161760
attaattttg ttgatttaga taaattaaat ccactttatc acacaattgt taccacatat 161820
gatgaaacaa cttcagtaca agaagttgga actcattcca ttgaaggccg tacatctatt 161880
gatggtttct tgatgtttga tgataatgag aaattgtgga gattgtttga cggggatagt 161940
aaagcacgtt tacgcattat aacgactaat tctaatattc gtccaaatga agaagtcatg 162000
gtatttggcg cgaataatgg aacaacccaa acaattgaac ttcagcttcc aactgatatt 162060
tctatcggtg atactgttaa gatttccatg aattatatga gaaaaggaca aacagttaaa 162120
atcaaagctg ccggtgaaga taaaattgct tcttcagttc aattgctgca atttccaaaa 162180
cgttcagaat acccacctga aactaaatgg gtgactgttc aagaattagt ttttaatggc 162240
gaaaccaatt atgttccagt tttacagctt gcttatatcg aagattccga tggaaaatat 162300
tgggttgtac agcaaaatgt tccaactgta gaaagagtag actctttaaa taattctact 162360
agagcaagat taggcataat tgctttagct acacaggctc aagctaatgc tgatctagaa 162420
aattctccac aaaaagaact ggcaattact ccagaaacgt tagctaatcg tactgctaca 162480
gaaactcgta gaggtattgc aagaatagca actactgctc aagttaacca ggatactaca 162540
ttctcttttg ctgatgatat tatcatcact cctaaaaagc tgaatgaaag aacagctact 162600
gaaactcgca gaggtgttgc cgaaattgct acgcagcaag aaactaatgc aggaaccgat 162660
gatacgacaa tcatcactcc taaaaagctt caagctcgcc aaggttctga atcattatct 162720
ggtattgtaa cttttgtatc tactgcaggt gctactccgg cttctagccg tgaattaaat 162780
ggtacgaatg tttataataa aaacactaat aatttagttg tttcgccaaa agctttggac 162840
cagtataaag ctacgcctac tcaacagggt gcagtaattt tagcagttga aagtgaagta 162900
attgctggtc aaagtcaaga aggatgggca aatgctgttg taacgccaga aacgttacat 162960
aaaaagacat caactgatgg aagaattggt ttaattgaaa ttgctacgca aagtgaagtt 163020
aatacaggaa ctgattatac tcgtgcagtc actcctaaaa ctttaaatga ccgtagagca 163080
actgaaagtt taagtggtat agctgaaatt gctacacaag ttgaattcga cgcgggcgtc 163140
gacgatactc gtatttctac accattaaaa attaaaacta gatttaatag tactgatcgt 163200
acttctgttg ttgctctatc tggattagtt gaatcaggaa ctctctggga ccattatacc 163260
cttaatattc ttgaagcaaa cgagacacaa cgtggtacac ttcgtgtagc tacacaagtt 163320
gaagctgctg ctggaaaatt agataatgtt ttaataactc ctaaaaagct tttaggtact 163380
aaatctactg aagcacaaga aggtgttatt aaagttgcaa cacaaaccga aactgttgct 163440
ggaacatcgg caaatactgc tgtatctcca aaaaatttaa aatggattgt gcagagtgaa 163500
cctacttggg cagctactac tgcagtaaga ggctttgtta aaacttcatc tggttcaatt 163560
acattcgttg gtaatgatac agccggttct acccaggact tagagctata cgagaaaaat 163620
agctatgcag tatcaccata cgaattaaac cgtgtattag caaattattt gccattaaaa 163680
gcaaaagctg cagatagtaa tttattggat ggtctagatt catctcagtt cattcgtagg 163740
gatattgcgc agacggttaa tggttcacta accttaactc aacaaacgaa tctgagtgcc 163800
cctcttgtat catctagtac tgctacgttc ggtggatcag tttcagcaaa tagtacatta 163860
actatttcta atactggaac agcaactcga ttgatttttg agaaaggacc tcaaactgga 163920
acaaacccag cccaaacgat gacggttaga gtgtggggaa atcaatttag tggggaatta 163980
gatacaacac gttctaccgt atttgaagtt agtgatgaaa catctagtca tttttattct 164040
cagcgcaata aagccggaaa tataacattt aatatcaacg gtacagtaac accgataaat 164100
gttaatgctt caggaacatt gaatgcaaat ggcgtagcaa catttggtaa ttcagtcact 164160
gcaactggtg aaattatttc tcgaagcgca aatgctttcc gtgctattaa cggaaattac 164220
ggttttattg ttcgcaatga tggatcagta acgaatttta tgcttactgc atcgggtgat 164280
cagactggtg gatttaatgg attacgccca ttagctatta ataatgcatc tggccaagta 164340
acgattggtg aaagcttaat cattgccaaa ggtgctacta taaattcagg tggtttgact 164400
gttaactcga gaattcgttc tcaaggtact aaaacatctg acttatatac acgtgcgcca 164460
acatctgata ctgtaggatt ctggtcaatt gatattaacg attcagctac ttataaccag 164520
ttcccaggtt attttaaaat ggttgaaaaa actaatgaag tgactggtct tccatattta 164580
gaacgtggcg aagaagttaa atctcctggt acactgactc agtttggtaa cacacttgat 164640
tcgctttatc aagattggat tacttatcca acgacaccag aagcgcgtac cactcgttgg 164700
acacgtacat ggcagaaaac caaaaattct tggtcaagtt ttgttcaggt atttgatgga 164760
ggtaaccctc ctcaaccgtc tgatatcggt gctttaccat ctgataatgc tacaatgggt 164820
aatcttacta ttcgtgattt cttacgaatt ggtaatgttc gcattattcc tgacccagtg 164880
aataaaactg ttaaatttga atgggttgaa taagaggtat tatggaaaaa tttatggcag 164940
agtttggaca aggatatgtc caaacgccat ttttatcgga aagcaattca gtaagatata 165000
aaataagtat agcgggttct tgcccgcttt ctacagcagg accatacgtt aaatttcaag 165060
ataatcctgt aggaagtcaa acatttagtg caggtcttca tttaagagtt tttgaccctt 165120
ctacaggagc attggttgat agtaagtcat atgctttttc tacttcaaat gatactacat 165180
ctgctgcctt tgttagtttc atgaattctt tttcaagcaa tagacttgtt gccatattaa 165240
ctagcggaaa ggttaatttt cctcctgaag tagtatcttg gttaagaacg gcaggaacat 165300
ctgcttttcc atctgattct ttattgtcaa gatttgacgt atcatatgct gccttttaca 165360
cttcttctaa aagagctatc gcactagagc atgttaaact gagtaacaga aaaagcacag 165420
atgactatca aactatatta gatgtagtat ttgatagttt agaagatgtt ggagcgacag 165480
gatttcctaa aagaacatat gaaagcgttg agcaatttat gtcagctgtt ggtggaacta 165540
ataacgaaat tgcacgtcta cctacagcat ctgcaataag taaactttct gactataatt 165600
taattcctgg agatgttctt tatcttaaag cacaactata tgctgatgct gatttattag 165660
cgttgggaac tactaatatt tcaattcgtt tttataatgc gtcgaatgga tatatttcct 165720
cgacacaagc tgagtttact ggacaggctg ggtcttggga attaaaagaa gattatgtag 165780
ttgttccaga aaatgcagtt ggatttacga tatacgcaca gagaactgca caagcgggtc 165840
aaggcggtat gagaaattta agcttttctg aagtgtcaag aaatggtggc atttcaaaac 165900
ctgctgagtt tggcgtcaat ggtattcgag ttaattatat ctgtgaatct gcttcacctc 165960
cggatataat ggtacttcct acgcaagcat cgtctaaaac tggtaaagtg tttggacagg 166020
aatttagaga agtttaaatt gagggagcct tcgggttccc tttttcttta taaatactat 166080
taaaataaag gggcatacaa tggctgattt aaaagtaggt tcaacaactg gaggctctgt 166140
catttggcat caaggaaatt ttccattgaa tccagccggt gacgatgtac tctataaatc 166200
atttaaaata tattcagaat ataataaacc acaagcaact gataacgatt tcgtttctaa 166260
agctaatggt ggtacatatt taaataaagt aatttttaat aaaggaatgg ctgttcctgg 166320
tgctgggtca ggtgacaacg gtatttttgc cggtcctggt gataatgcta catatgatac 166380
tacaaatatg gatattgttt catggtatgg tatcggcttt aaatcatcac aaggggcagc 166440
aggtagaact gtagtaatta acacacgaaa cggagatatt agctcaaagg gtgtaattga 166500
agcatcacaa atacgcgcaa cttcgttatc accagtaaat aattatgacc ttacgagaaa 166560
agattatgtt gatggagcaa taaatattgt tacaacaaat gcaaactcta gagtattacg 166620
ctctggagac actatgacag gaaatttaac tgcgccaaac cttttttcac agaatcctgc 166680
atctcaacca tcgcatgttc cgcgatttga ccaaatcgta attaaggatt ctgttcaaga 166740
tttcggctat tattaagagg acttatggct actttaaaac aaatacaatt taaaagaagc 166800
aaaacggcag gtcaacgtcc agctgcttca gtattagccg aaggtgaatt ggctataaac 166860
ttaaaagacc gtgtactttt tactaaagat gaccagggaa atattattga tttaggtttt 166920
gctaaaggcg gtagtattga cgggaatgtt attcatacag gcaattataa ccaaactggc 166980
gattatactt taaatggcgt cttcactcag actggtaatt ttaatttaac tggtattgct 167040
cgagtaactc gcgatattat tgccgctggg cagattatga ctgaaggcgg agaacttatt 167100
acaaaaagtt caggaacggc acacgttcgt tttcatgatt ccgccgaccg tgaacgcggt 167160
attatttttt ctcctgctaa tgacggttta actacacaag tagttaacat cagagttcaa 167220
gattacaaag ctggttcaga aaacactttc gcttttaatg gaaatggttt gttttcttca 167280
ccagaagttt ttgggtggaa atctgtatca actccggtaa tttataccaa taaagttatc 167340
accaataaaa aagttaaaga tgattatgac atctattcga tggcagacaa tgttccattg 167400
tctgaaagca ctactgctat taatcatctt cgtgttatgc gtaatgcagt tggttctggt 167460
attttccatg aagttaaaga taatgatgga ataacatggt atagtggaga tggattagac 167520
gcttatcttt ggtcatttac ttggagcggc ggaattaaat caagtcactc aatttccatc 167580
ggtttaacac ccggacctaa ggattactca atattaggac cgtctagtat cgctttagga 167640
gataatgata ctggatttaa atggcatcaa gacggatatt atttcagtgt taataatggc 167700
acaaaaacgt ttttatttag ccctagcgaa acaactagcc taagaaaatt tgtagctgga 167760
tattctacta atggaaccga tttaactact cctccgactg aaaactatgc tcttgctact 167820
gtcgtgacat atcatgacaa taacgcgttt ggagatggtc agactctttt ggggtattat 167880
caaggtggta attatcacca ctatttccgt ggtaagggta ctacaaacgt taacactgca 167940
ggtggtctgt tagtcactcc tggtaatatt gatgttgttg gtggttctgt taatatcgat 168000
ggtagaaata atgcctctac gctgatgttt agaggtaaca caactggtag cagttcagtt 168060
gataatatga ctatcagcgt ttggggtaat acctttacta atcctagtga aggcacccgt 168120
aaaaacgtaa tggaaatatc tgatgctact agctggatgc aatatattca acgaacaact 168180
gctggtaaag tcgaatcggt tctaaatggc acccagattg ttaatgaaaa cttgactgta 168240
gtaaaaaatg ctacatttga cggtacaatc agcgcagccg gtgaaatcgc gacaaatgct 168300
gtaaatggtc ttcgtatttg gaacaatgat tacggtgcca tttttagacg ttcagaagga 168360
agtcttcata ttattcctac cgagtttgga caaggtaaaa ccggcgatat cggtccactt 168420
cgtccattta gtttggcttt agataccggt aaggttgtta ttcctgactt agatttgagt 168480
catacgactt ttgctgaaaa tggttttatt aaatttggcg gtcatggcgc tggtgcaggc 168540
ggttacgata ttcaatatgc acaagcagct cctgttttcc aagaaattga tgatgacgcg 168600
gtaagtaaat attatcctat tgttaagcag aaattctt 168638
Claims (10)
- ESBL(Extended Spectrum β-lactamase) 생성 대장균(Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어지고, 기탁번호 KFCC11675P인, 박테리오파지 ECO4.
- 삭제
- 제1항에 있어서, 상기 ESBL 생성 대장균은 베타락탐계 항생제에 내성을 갖는 것인, 박테리오파지 ECO4.
- 삭제
- 제1항의 박테리오파지 ECO4를 포함하는, 항생용 조성물.
- 제1항의 박테리오파지 ECO4를 포함하는, 사료 첨가용 조성물.
- 제6항의 사료 첨가용 조성물을 포함하는, 사료.
- 제1항의 박테리오파지 ECO4를 포함하는, 소독제.
- 제1항의 박테리오파지 ECO4를 포함하는, 세척제.
- 제1항의 박테리오파지 ECO4를 인간을 제외한 개체에 투여하는 단계를 포함하는, ESBL 생성 대장균에 의한 감염성 질병의 예방 또는 치료방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20160176714 | 2016-12-22 | ||
KR1020160176714 | 2016-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20180073448A KR20180073448A (ko) | 2018-07-02 |
KR101993125B1 true KR101993125B1 (ko) | 2019-06-26 |
Family
ID=62914225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020170169340A KR101993125B1 (ko) | 2016-12-22 | 2017-12-11 | 신규한 esbl 생성 대장균 특이 박테리오파지 eco4 및 이를 포함하는 항균 조성물 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR101993125B1 (ko) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016509838A (ja) * | 2013-02-27 | 2016-04-04 | シージェイ チェルジェダン コーポレイション | 新規なバクテリオファージ及びこれを含む抗菌組成物 |
JP2016515802A (ja) | 2013-02-27 | 2016-06-02 | シージェイ チェルジェダン コーポレイション | 新規なバクテリオファージ及びこれを含む抗菌組成物 |
-
2017
- 2017-12-11 KR KR1020170169340A patent/KR101993125B1/ko active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016509838A (ja) * | 2013-02-27 | 2016-04-04 | シージェイ チェルジェダン コーポレイション | 新規なバクテリオファージ及びこれを含む抗菌組成物 |
JP2016515802A (ja) | 2013-02-27 | 2016-06-02 | シージェイ チェルジェダン コーポレイション | 新規なバクテリオファージ及びこれを含む抗菌組成物 |
Non-Patent Citations (2)
Title |
---|
Escherichia phage slur13, complete genome, GenBank: LN881737.1, 2016.03.25.* |
Genome Announcements. 2015, Volume 3, Issue 6, e01364-15.* |
Also Published As
Publication number | Publication date |
---|---|
KR20180073448A (ko) | 2018-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101649851B1 (ko) | 신규한 시가독소생산 F18형 대장균 박테리오파지 Esc-COP-1 및 이의 시가독소생산 F18형 대장균 증식 억제 용도 | |
KR102003770B1 (ko) | 신규한 포도상구균 특이 박테리오파지 sa3 및 이를 포함하는 항균 조성물 | |
CN107109373B (zh) | 新型噬菌体以及包含其的组合物 | |
CN110545670B (zh) | 噬菌体疗法 | |
PH12015501888B1 (en) | Novel bacteriophage and antibacterial composition comprising the same | |
KR102073095B1 (ko) | 대장균 박테리오파지 Esc-COP-14 및 이의 병원성 대장균 증식 억제 용도 | |
KR101993121B1 (ko) | 신규한 클로스트리디움 퍼프린젠스 특이 박테리오파지 cp3 및 이를 포함하는 항균 조성물 | |
KR102432624B1 (ko) | 신규한 스타필로코커스균 특이 박테리오파지 opt-sc01 및 이를 포함하는 항균 조성물 | |
KR102016922B1 (ko) | 신규한 병원성 대장균 특이 박테리오파지 ec10 및 이를 포함하는 항균 조성물 | |
KR101993123B1 (ko) | 신규한 병원성 대장균 특이 박테리오파지 eco5 및 이를 포함하는 항균 조성물 | |
KR101587113B1 (ko) | 치주염 유발 장알균(Enterococcus faecalis)을 특이적으로 사멸시키는 신규한 박테리오파지 | |
KR101863593B1 (ko) | 신규한 살모넬라균 특이 박테리오파지 sp1 및 이를 포함하는 항균 조성물 | |
KR101993125B1 (ko) | 신규한 esbl 생성 대장균 특이 박테리오파지 eco4 및 이를 포함하는 항균 조성물 | |
KR102237011B1 (ko) | 병원성 살모넬라균 특이 신규 박테리오파지 kfs-sm 및 이를 포함하는 항균 조성물 | |
KR102016919B1 (ko) | 신규한 살모넬라균 특이 박테리오파지 sc1 및 이를 포함하는 항균 조성물 | |
KR102193495B1 (ko) | 신규한 아시네토박터 바우마니 균 특이 박테리오파지 ab63 및 이를 포함하는 항균 조성물 | |
KR101896512B1 (ko) | 신규한 사이트로박터 프렌디 특이 박테리오파지 cf1 및 이를 포함하는 항균 조성물 | |
KR102203675B1 (ko) | 신규한 여시니아균 특이 박테리오파지 ye12 및 이를 포함하는 항균 조성물 | |
KR101993124B1 (ko) | 신규한 살모넬라균 특이 박테리오파지 sg1 및 이를 포함하는 항균 조성물 | |
KR101871347B1 (ko) | 신규한 병원성 대장균 특이 박테리오파지 ec121 및 이를 포함하는 항균 조성물 | |
KR102269089B1 (ko) | 항생제 내성을 갖는 아시네토박터 속의 균을 용균하는 신규한 박테리오파지 | |
KR102193473B1 (ko) | 신규한 클렙시엘라 속 세균 특이 박테리오파지 kp12 및 이를 포함하는 항균 조성물 | |
KR102066898B1 (ko) | 신규한 장알균 특이 박테리오파지 ef5 및 이를 포함하는 항균 조성물 | |
KR20180074608A (ko) | 신규한 클로스트리디움 퍼프린젠스 특이 박테리오파지 cp5 및 이를 포함하는 항균 조성물 | |
KR101992013B1 (ko) | 병원성 장내세균에 대해 사멸능을 갖는 신규 박테리오파지 및 이의 용도 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant |