KR102016919B1 - 신규한 살모넬라균 특이 박테리오파지 sc1 및 이를 포함하는 항균 조성물 - Google Patents

신규한 살모넬라균 특이 박테리오파지 sc1 및 이를 포함하는 항균 조성물 Download PDF

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KR102016919B1
KR102016919B1 KR1020170178613A KR20170178613A KR102016919B1 KR 102016919 B1 KR102016919 B1 KR 102016919B1 KR 1020170178613 A KR1020170178613 A KR 1020170178613A KR 20170178613 A KR20170178613 A KR 20170178613A KR 102016919 B1 KR102016919 B1 KR 102016919B1
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bacteriophage
salmonella
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feed
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김영주
연영은
한범구
김현일
박철세
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Abstract

본 발명은 살모넬라균에 특이적인 사멸능을 갖는 신규 박테리오파지 SC1, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 SC1은 기존의 항생제 등의 화학물질에 비해 살모넬라균에 대한 특이성이 매우 높고, 살모넬라균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한, 본 발명의 박테리오파지 SC1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SC1은 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.

Description

신규한 살모넬라균 특이 박테리오파지 SC1 및 이를 포함하는 항균 조성물{Novel Salmonella specific bacteriophage SC1 and antibacterial composition comprising the same}
본 발명은 살모넬라균에 특이적인 사멸능을 갖는 신규 박테리오파지 SC1, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
살모넬라(Salmonella)는 장내세균과에 속하는 그람음성의 통성혐기성 세균으로, 아포를 형성하지 않는 간균이다. 살모넬라균은 사람뿐만 아니라 돼지, 소, 닭 등을 비롯한 다양한 가축에 감염되어 질병을 유발하는데, 사람에게 감염되어 식중독을 유발하고 동물에게 있어서는 다양한 살모넬라증 (Salmonellosis)을 유발하는 병원성 미생물이다. 살모넬라 엔테리카 (Salmonella enterica)는 혈청학적 구분에 의해 장티푸스를 일으키는 살모넬라 타이피 (Salmonella Typhi), 쥐티푸스의 원인균인 살모넬라 티피뮤리움 (Salmonella Typhimurium), 장염균인 살모넬라 엔테리티디스 (Salmonella Enteritidis), 가금티푸스의 원인균인 살모넬라 갈리나륨 (Salmonella Gallinarum), 추백리 원인균인 살모넬라 플로럼(Salmonella Pullorum), 급성 패혈증 및 돼지 콜레라의 원인균인 살모넬라 콜레라수이스(Salmonella Choleraesuis) 등의 혈청종을 포함한다. 살모넬라균은 혈청형에 따라 인간뿐만 아니라 가축에게도 질병을 일으킬 수 있는 인수공통 감염원을 포함한다. 살모넬라 콜레라수이스 (Salmonella Choleraesuis)는 돼지에 감염되어 돼지 콜레라를 일으킬 수 있어 돼지 콜레라균으로 잘 알려져 있는 균으로 사람과 동물 모두에게 감염되는 균이다. 이 균은 살모넬라 타이피수이스(Salmonella Typhisuis)와 함께 살모넬라에 의한 급성 패혈증을 일으키며, 살모넬라 감염에 의한 돼지의 급성 또는 만성의 소화기 전염병은 돼지 파라타이포이드(paratyphoid)라 불리우며, 위장염 및 패혈증을 동반하고 주로 비육기에 많이 발생한다. 이 균에 의한 질병의 발생은 계절적으로는 주로 여름에 흔히 발생하며 급성패혈증형은 2~4개월령의 어린 돼지에서 흔히 발생하며, 주된 증상은 체온상승(41~42℃), 원기소실과 식욕감퇴, 귀 주위와 다리 부위에 청색증(cyanosis)이 생기며, 발병 2~4일 이내에 대부분 폐사된다. 급성 장염형은 비육기 가축에 주로 발생되며 식욕이 일정하지 않고 심한 수양성 설사와 고열, 원기쇠약, 폐염 및 신경증상을 동반하며 중증의 경우 피부변색이 나타난다. 만성 장염형은 가축이 계속적인 설사로 인하여 심하게 여위여 있고 초기 황백색 또는 회백색의 연변에서 점차적으로 젤라틴량의 점액성 설사로 변하고 설사변은 장점막상피세포의 괴사편을 함유하고 있으며 간혹 혈액이 섞여 있는 경우도 있다. 국내의 경우 상기 균에 의한 질병 발생은 빈도가 매우 낮은 것으로 보고되고 있으나, 질병이 발생하면 전염성 및 피해가 크게 나타날 수 있다. 또한, 살모넬라균이 전염되는 경우의 대부분이 그렇듯이 오염된 원료사료나 물 또는 별 증상 없이 균을 보균하고 있는 성돈이 중요한 전염원이 될 수 있다.
현재 살모넬라 감염증을 예방 및 치료하기 위해 항생제를 주로 사용하고 있으나 살모넬라는 동물에 감염 시 세포 내에 침투하여 증식하고 감염하는 경우가 많아 항생제나 약제, 기타 생균제가 침투하여 작용하기는 어려우며, 최근 많은 분야에서 항생제 내성에 대한 문제가 발생하고 있어 이에 대한 원인을 항생제 오남용으로 규명하고 항생제를 충분히 사용하지 못하게 되었다. 이에 따라 산업동물의 배합 사료 내에 성장촉진제로 사용하는 항생제를 금지하기 시작하였고, 유럽연합에서는 2006년부터, 우리나라에서는 2011년 하반기부터 항생제 사용을 규제하기 시작하였다. 또한, 항생제가 없는 안전한 먹거리에 대한 소비자의 요구가 증대되고 있어 점차 항생제 사용이 줄어들고 있다. 세균을 제어하는 항생제의 사용이 줄어듦에 따라 세균성 질병의 발생이 증가하고 있어 항생제를 사용하지 않고 세균성 질병을 제어하는 방법에 대한 요구가 늘어나고 있다. 이러한 연구 중 하나가 자연계에 존재하는 세균을 특이적이고 효과적으로 사멸하는 박테리오파지를 이용하는 방법이다.
박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
그러나 현재까지 양돈이나 양계 산업에 막대한 경제적 피해를 일으키고, 사람까지도 감염시킬 수 있는 살모넬라균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 살모넬라균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
이에 본 발명자들은 살모넬라균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 살모넬라균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SC1을 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지 SC1을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 SC1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SC1을 제공한다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 SC1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 SC1는 기존의 항생제 등의 화학물질에 비해 살모넬라균에 대한 특이성이 매우 높고, 살모넬라균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한, 본 발명의 박테리오파지 SC1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SC1은 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 살모넬라 콜레라수이스에 대해 특이적인 박테리오파지의 스크리닝 결과를 나타낸 도이다.
도 2는 박테리오파지 SC1의 살모넬라 콜레라수이스에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 SC1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 SC1의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 SC1의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 SC1의 열 안정성을 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SC1을 제공한다.
본 발명에서, 용어 “박테리오파지(bacteriophage)”는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명에서, 상기 살모넬라균은 살모넬라 콜레라수이스(Salmonella Choleraesuis), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 플로럼(Salmonella Pullorum)으로 구성된 군으로부터 선택된 1종 이상 일 수 있으며, 바람직하게는 살모넬라 콜레라수이스(Salmonella Choleraesuis)이다.
본 발명의 박테리오파지 SC1은 살모넬라균, 특히 살모넬라 콜레라수이스에 대해 용균활성이 탁월하다. 상기 박테리오파지 SC1은 200-220 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속한다. 본 발명의 박테리오파지 SC1의 단백질 패턴 분석 결과 100 kDa, 70 kDa, 65 kDa, 52 kDa, 37 kDa, 35 kDa, 그리고 33 kDa 크기의 단백질을 포함하는 것을 확인하였다. 또한 상기 박테리오파지 SC1은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.
본 발명의 박테리오파지 SC1은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 SC1은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 살모넬라균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 SC1을 살모넬라균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 SC1을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 SC1은 도축장 및 양돈 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 박테리오파지 SC1로 명명하고 2016년 12월 02일에 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하여, 기탁번호 KFCC11709P를 부여받았다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 “항생용 조성물”은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 SC1은 기존 항생제에 비하여 살모넬라균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 사료 첨가용 조성물을 제공한다.
축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 SC1을 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해 효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에(Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 SC1을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 SC1을 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 SC1 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 살모넬라균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 소독제를 제공한다.
살모넬라균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 SC1을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SC1을 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 SC1은 살모넬라균에 특이적 사멸능을 가지므로, 상기 살모넬라균에 노출되었거나 노출될 가능성이 있는 가축의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 SC1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
상기 살모넬라균은 살모넬라 콜레라수이스(Salmonella Choleraesuis), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 플로럼(Salmonella Pullorum)으로 구성된 군으로부터 선택된 1종 이상 일 수 있으며, 바람직하게는 살모넬라 콜레라수이스(Salmonella Choleraesuis)이다.
본 발명의 방법은 살모넬라균에 의한 감염성 질병, 예컨대 유행성 또는 급성으로 발병하는 전염성 질환으로, 살모넬라증 외에, 식중독, 위염, 장염, 폐렴, 패혈증, 돼지 콜레라 및 추백리가 발생한 개체 또는 발생 위험이 있는 개체에 박테리오파지 SC1을 투여하는 단계를 포함한다.
본 발명의 용어 “예방”이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 “치료”란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
상기 살모넬라증은 살모넬라균 감염에 의해 발열, 두통, 설사, 구토 등을 수반하는 증상을 총칭하는 것으로, 살모넬라증은 장티푸스와 같은 증세를 나타내는 패혈증형과 식중독 증세를 나타내는 급성위장염형으로 대별되며, 장염, 식중독, 급성 균혈증 등이 포함된다.
바람직하게, 상기 살모넬라 콜레라수이스에 의한 감염성 질병은 위염, 장염, 패혈증 및 돼지 콜레라일 수 있으나, 이에 제한되는 것은 아니다.
바람직하게, 상기 살모넬라 플로럼에 의한 감염성 질병은 추백리일 수 있으나, 이에 제한되는 것은 아니다.
바람직하게, 상기 살모넬라 엔테리티디스에 의한 감염성 질병은 식중독, 장염, 폐렴 또는 패혈증일 수 있으나, 이에 제한되는 것은 아니다.
본 발명에서, 용어 "개체"는 살모넬라균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다. 예를 들어, 본 발명의 박테리오파지 SC1은 돼지 콜레라의 원인인 살모넬라 콜레라수이스에 특이적 사멸능을 가지는바, 바람직하게는 돼지에 투여될 수 있다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 SC1 또는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 약학적 제제(약학적 조성물과 혼용됨)는 유효성분 외에 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, “약학적으로 허용 가능한 담체”란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 SC1을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마스네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
본 발명의 방법에서 상기 박테리오파지 SC1 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 SC1의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.
실시예 1: 신규한 박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리
살모넬라 콜레라수이스에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장 및 양돈 농장 부근의 하수로부터 채취하였으며, 박테리오파지 분리에 사용된 살모넬라 콜레라수이스는 (주)옵티팜에서 채취한 야외 시료로부터 분리 동정된 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 살모넬라 콜레라수이스와 함께 35℃에서 24시간 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 um인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 상기 여과액을 이용하여 스팟 테스트를 통해 대상 시료에 살모넬라 콜레라수이스를 용균할 수 있는 박테리오파지가 존재하는지 스크리닝을 수행하였다. 그 결과를 도 1에 나타내었다.
다음으로 전배양된 살모넬라 콜레라수이스 150 uL를 취해서 멸균된 튜브에 넣고 3 mL의 LB 탑 아가(top agar) [LB 배지(트립톤 10 g/L, 효모 추출물(yeast extract) 5 g/L, NaCl 10 g/L) + 0.6% 아가]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% LB 아가 플레이트에 중층하였다. 이를 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 uL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 uL를 취하고, 대상 세균(살모넬라 콜레라수이스) 배양액 150 uL에 혼합한 후 0.6% LB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% LB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 uL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간동안 방치하였다. 상기 박테리오파지액 100 uL를 0.6% LB 탑 아가와 세균 배양액 500 uL와 혼합한 뒤 150 mm 지름의 LB 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, LB 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 um 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 4-6 mm의 크기를 가지는 용균반을 확인함으로써, 상기 박테리오파지가 살모넬라 콜레라수이스에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예 1.1에서 확인한 살모넬라 콜레라수이스 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x107 PFU/mL로 희석한 후 전배양된 살모넬라 콜레라수이스 1.0x109 CFU/mL과 혼합하고 MOI (Multiplicity of infection)를 0.01이 되도록 하여 35℃에서 120 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 um 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 SC1(Bacteriophage SC1)"로 명명하고, 2016년 12월 02일에 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 수탁번호 KFCC11709P를 부여받았다.
실시예 2: 박테리오파지 SC1의 전체 유전자 분석
박테리오파지 SC1의 전체 유전자를 분석하기 위해, 박테리오파지 SC1 배양액에 20 mM EDTA, 50 ug/mL의 프로테나아제 K, 0.5%(w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 uL가 되도록 TE 완충액 (Tris-EDTA, pH 8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 HiSeq 2500(Illumina, USA)를 이용하여 유전자 시퀀싱을 시행하였다(마크로젠, 한국).
그 결과, 박테리오파지 SC1의 전체 유전자의 크기는 151,249 bp이며, GC 함량이 45%, 전체 ORFs의 수는 175개임을 확인하였다. 박테리오파지 SC1의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예 3: 박테리오파지 SC1의 형태학적 특성
박테리오파지 SC1의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경 (Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 SC1은 200-220 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.
실시예 4: 박테리오파지 SC1의 단백질 패턴 분석
박테리오파지 SC1의 단백질 패턴을 분석하기 위해, 1.0x1010 PFU/mL로 준비된 박테리오파지 SC1 40 uL를 10 uL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 SC1은 100 kDa, 70 kDa, 65 kDa, 52 kDa, 37 kDa, 35 kDa, 그리고 33 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예 5: 박테리오파지 SC1의 다양한 세균에 대한 감염성 조사
박테리오파지 SC1의 다양한 세균에 대한 감염성을 조사하였다.
박테리오파지 SC1이 살모넬라 콜레라수이스 외의 다른 살모넬라 균주에 대하여 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 살모넬라 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 1에 나타내었다.
Figure 112017128498914-pat00001
(+: 용균활성 있음, +/-; 약한 용균활성 있음, -; 용균활성 없음)
상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 SC1은 살모넬라 콜레라수이스 외에도, 살모넬라 엔테리티디스 및 살모넬라 플로럼에 대해 약한 용균활성을 나타냄을 확인하였다.
다음으로, 박테리오파지 SC1이 살모넬라 외의 다른 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.
Figure 112017128498914-pat00002
표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 SC1은 Escherichia coli , Bacillus cereus 등의 병원성 미생물과 Bacillus subtilis , Lactobacillus plantarum 등 생균제로 흔히 사용되는 균주 등 살모넬라균이 아닌 다른 속의 세균에 대해서는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 SC1은 살모넬라균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예 6: 박테리오파지 SC1의 pH 안정성 조사
박테리오파지 SC1의 pH에 대한 안정성을 확인하기 위하여, 다양한 pH 범위(pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 uL로 분주하여 준비하였다. 박테리오파지 SC1 배양액을 2.0x109 PFU/mL가 되도록 준비한 다음 배양액을 10 uL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 SC1은 pH 3-11의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 SC1은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
실시예 7: 박테리오파지 SC1의 열 안정성 조사
박테리오파지 SC1의 열 안정성을 확인하기 위하여, 50℃, 60℃, 70℃ 및 80℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 SC1 배양액을 2.0x108 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 10분, 30분 및 1시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.
도 6에 나타낸 바와 같이, 본 발명의 박테리오파지 SC1은 50-80℃의 범위에서 30분 까지 안정한 것을 확인하였다. 이를 통해 박테리오파지 SC1은 내열성이 우수한 박테리오파지임을 알 수 있다.
상기 실험으로부터 박테리오파지 SC1은 살모넬라균, 특히 살모넬라 콜레라수이스에 대한 특이성이 매우 높고, 살모넬라균에 감염하여 살모넬라균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한, 본 발명의 박테리오파지 SC1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SC1은 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
이하, 제제예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 제제예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 제제예에 의해 제한되는 것으로 해석되지 않는다.
제제예 1. 사료 첨가용 조성물
박테리오파지 SC1 1x107 PFU/mL
비타민 믹스 100 mg
미네랄 믹스 100 mg
스테아린산 마그네슘 2 mg
통상의 사료 첨가제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.
제제예 2. 소독제 조성물
박테리오파지 SC1 1x107 PFU/mL
에탄올 적량
멸균 증류수 적량
pH 조절제 적량
통상의 소독제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.
제제예 3. 세척제 조성물
박테리오파지 SC1 1x107 PFU/mL
에탄올 적량
효소 복합물 적량
멸균 증류수 적량
통상의 세척제 제조방법에 따라 상기의 성분들을 혼합하여 제조한다.
이상, 본 발명내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의해 정의된다고 할 것이다.
한국미생물보존센터(국내) KFCC11709P 20161202
SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Salmonella specific bacteriophage SC1 and antibacterial composition comprising the same <130> OTP1-42p <150> 10-2016-0177977 <151> 2016-12-23 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 151249 <212> DNA <213> bacteriophage SC1 <400> 1 atgaaaatgc gcaagtccga gcatttcgtg cgctcttctt ctaccatcgt cggacagaca 60 ttcaatgtca agatgacgga taaattattt gaaacattat tttcaagtct ctacaaatat 120 aaagaggcgg cgtctttgcg tgagacgttg tgtaatggta tagactcgca taatatgcgt 180 gatcgccaac aacgctggat gccgtcgcat tatgctcctc tcacccctat gcctcaacga 240 tacagcaaac atcttgcccc caagggaact cctgttgttg tacatttacc ggatgttatg 300 gaaccctggc tggaaattaa agattatggg gttggtcttc cattagaaat gatcatcggc 360 gagcctatta cagcgcgtga agatgaagtg ctggttgaag gtaatatcgt cgtgaaggaa 420 gacgaaatcc ctgatagcac tgctgttatt ggtacacctg gttattataa tggggtactg 480 gtattccgcg ctgaggatgg cgagatcatt cgtggacctg gtttgtatac aacactcttc 540 catagtacaa aagaggacga cgacgggcaa ataggggcgt ttgggctagg ttctaaatcc 600 ccatttgctg tatctgattc atttacagta gaaagtcgct atgaagggaa actgtatcgc 660 ttcctgatgt atctgaatgc ggacagaatc ccaactgtag atctcattac caaggattta 720 gatacccgtg atcctaaacc ggaagacact gatgagttca acggcctgac tgttaaagtt 780 cctgtaaaga atcagcgttt taccgccttt gaacaagagt tggtccgttt gggtcgagtg 840 atgcgacctt caatgcgacc gaaggttgaa aacgccagtt attctttccg ttggtctgac 900 atcaacttcg aaaaccgtgt aggcaacaca tatatccaac cgaagtcaga ttccgacaac 960 atccactatg ctgtcatggg cggggtttct tacccgatag atctcgacca attggactct 1020 gaaatatgca ccgtgctgga aaaattcccg agttcctata ccttcttcga acttggagaa 1080 ttgaatgttc ctccatcacg tgaagacttg tcatatgacg agttcacccg tgaaagcctg 1140 aaccgcgtgt tcaagcatgt ggctgacaat attatgcagg cgaagatgta tgaacttcgc 1200 caagcggagt caatgggtcc tcttatgttg tatatgaaaa agactcagct gactgatatg 1260 ttcggtagcg gtttccgtaa attggtcgaa cgggaatttc ctgcagataa ccgtttctac 1320 aaaggcacgt tccgttatat cggagcgccg gacgtcgtgc gcgattactc tttggatgca 1380 cctttccggt ctattggtag tccttacgaa attgaagtac acgacaacgg tgtagtacac 1440 gacagcattt atgtgaactc tgtcggaaat tggttgaaat ctaaatcaaa aattgctgtt 1500 attattgata actcgaatcg tgctcgaaac ctgaagatac aaacagcacg caataacttc 1560 aatgtcgtta tcgtcgtcaa accgaatgaa aattatttca gtaatcggaa tcagctggcg 1620 gcacataaag aatcatttac caaccatgag gaattgaagt cttattttga atcatggatc 1680 ggtgtacaag aaacaacgcc ggactacctg gtctttgccg ataaactgat cgaggtcttt 1740 ggcgatttat tcaatccgga tgaagtctat ttcatgcatg aaatggaata tgttcgcccg 1800 accgttgaaa aagatcctgg gatgtttagt ttccattaca attcatttaa cttcgatagc 1860 gtttatgaat tggatggaaa aaccgtttca aatattattg attcaggcaa aaagatcgta 1920 tatatcgaag tatctggccg agaaggtatc cataaaattc atggtaatac cttacgacaa 1980 tccacggctg gacatttgcg tgaagcgatg gaaagaacga agttcggcga gaatggaaac 2040 gaaaacctgt ttgatttgct gggagcacac ccaacaatcg ttcttgcgcg tcgtaaatct 2100 gttccgatga tgaagaaatt cccagaagta ttcatcccca ttgacgcagt gtttgatatg 2160 ttgcttgagc attataaaga tgaatttcag gcgcttgaat ctaagaaact cctgaaactt 2220 cgcaagggca taaacatcat gtctcatcgc attgattatg gtgccaagct gttgattgat 2280 tcccatggaa aagttacgga tggctatgcc catcatcaac acagggcaaa agcaatcatc 2340 ggttatgcga aacaacaaat cactgaagaa gaatggaaga ttgttcgtat gctggccaaa 2400 cgaaatccgt ctggatcggg gtacggttat ttccgcaagg ctgttgagga attacattat 2460 catatagaaa tgcctttctc aactacgaga tttttccgcg cctgtaacca gttaactcaa 2520 gttgttgatt tattgaatga aaaattaact gctgaaggat ttgatgagat aaaggtcact 2580 agcactatat ctcaaaagca aaaggccaaa aaccgatacc gagttgaatg tcatcgtttg 2640 gtgaaattca tgatgtcaac atatcagcct tcggcacaca acgcgattga agatgccact 2700 agatttgtga aggctatttc aaaacgtatt ctcggggcat aatagcccca ttaccccaca 2760 gtgagaacta caagatgaat gctatagaaa aacgtattct caagctgttg aatgagaaca 2820 gaagtcaaag ttcaatagcc agtgaattgg gcgtaccgcg ctcaatgata caacgcgtgt 2880 cggataaaga actgggagtg gatccagctt cgattaagtc tctgaccact gaacagattc 2940 aagaaataca aaccaagagc agcaaaggtg aaagcaattc ttctctggca tcagtttatg 3000 gcgtcagtgc caaaacaatt gcccgcgccc tgatggttcg tatcatcaaa gaatctaata 3060 acgtggtcgt gatttcgcca attaaagaat tgactgaaga agggaaaatc cccgacacct 3120 atgaagttct ggaaggttcg gtgtctgtcg attctgaagg cgaagaatgg tatgttggcc 3180 gtttcctgga aaaccaaaca gtgtttatct gtatgcgtta cgatagctct gctgctattc 3240 aggccaaact tttcagaagc gaagaactga aaccgttaga aactcggtca agccgcttca 3300 atgaagaaaa catttctccg ttggccgaat tggcgacagc actggttgat ggcgttacca 3360 aagtcaatga cggcgtggta atcagtgtac aacatgacgg cgaaacatac ccgatgcgcg 3420 gttcccttga tgcccgtcgg cgtgtgggat actttgacgc aattttgggg cgtacacttc 3480 gactggcgtt gtcgtctgtt gttttctcgg ttaagacaac ggctgttgag gaagagtctg 3540 gcgacaaaca aactcaaaac tcatttaaag aaaaagatct gtcagtgttc ttgaatgagc 3600 accagatcat gattttaccg gaaagcatcg ttatcgttat ggatggcaaa ccggaaacga 3660 taaccacaag ccatcaggcg tatgatcgta ttgttgaagc gattaaaaat cgtgacgtca 3720 aaacagcgta cactctgatg aaaccgcgtg aagccatcag caaattcact acaggcatgg 3780 ttgatttatc tgacaaccgt gtgcgctggg gtggctatga catcacggga acttccgtcg 3840 ccaaacgcgt tttggcactg gcattaaaag gcgattatcc gaacttagaa cgcttgggtc 3900 gttttctgga caaaatgttc caaaacccga gcgcggcgct ggttcagtcc ggtcgaatct 3960 atgaattcat ggcatattcg gatatcgaaa ttcatgaaga cggtgatatc atcctgtata 4020 aatccgttcg cggtaactac atggacaagc gcacaggaaa agttagtaat gctcctggca 4080 ccattgttcg aatggctcgc tcatttgtga acgataacaa caaagatctg tgctcttacg 4140 gtcttcacgt ttgttctctg gcttatctga aacaatgttt tggtagcctg ggacaacgcg 4200 ttgtccgttg caaactgaac ccgaaagata tcgtgtctat cactgatgat tatggctcca 4260 gtaaaatccg ctgctgtgaa tatctggtat tagacgatta caccacggaa tacaaccgcc 4320 aacataaatc cattgatgtt gaaggtctat acaagtaacc gcgaactgac ataaaagagg 4380 gggcttcggc ctccttttct ttgaggtcga tatggaaacc agagatgttt acttcgtgta 4440 tgagcaacag gcatttggat cactgcgccg aaaaacaaag ttccttgttg attcattcca 4500 atttgatgga gaactcaagg aatactcgtt caggaatttt cctccgagag aagtcatagg 4560 cgaccagttc gtgaaattat tttgtcgttg tggcggctgt gactttaacg acgacggata 4620 ttccatgcat gtttattgct gcaattgttg tggtaaatat attacagtct ataggagaac 4680 tgatcatggc gaagacacaa aagaaaattg aaaacactca aaccattcaa gaaatcactg 4740 cacaggaaga aaataaactt cccagttatc tgcaacgcgt ggtggataac gtgcctcagg 4800 gcggcgacgg cggtattgtc tacgctggtg actacggttg ggtgtgtgaa tataaagacg 4860 gctctaagga gcttctagag gaactcaccg gacttgccgg aactttgcgc cgttatgggt 4920 tagataaatt cggtaaacct atgaaaccag gtactgtggt atcaaccgat attacagttg 4980 aagttcttct tttgcttgat atcaatgatc ttaagacact tgcggaaccc ctgggtatcg 5040 acgcgactga ccgtaatgaa ataatctcgc aattgactga aaaactgcag attaaataat 5100 cccagtgtat aactgctgat tataattcaa tatggctatc gttgacgaaa gcaatttgat 5160 ggagtacgct ctaagacatt atatcacccc tggtgtctca agagatgatt tgatggtaga 5220 cattcagcga atttcgctaa ttaatcaatc attgaaaaga tttgtgccag ggaaaagtcc 5280 tcgcgtactt atcaatcaat tgattattct tttcaatacc tttgaaaccg aagccgtgtg 5340 ccgaatgttg gtgttgaaaa cggataagaa ccaacatcct cgtcttaaag cagcgctgtt 5400 gacgttagga gtttggcgag atgatttatg ttccggttca tacgaaccag ataatgagct 5460 gatgatggct ctgaacaacg atttggatga gtggaggaaa ccatgccaac aatcacagta 5520 ttagtcgcac cggaagttgt ccgcaacaaa cccgaaaccg aacgcaatca tgtcgtgacg 5580 ggtgttgcaa agggttggca aaagaccagc ctcaaccaag atcctgacga gatcctgacc 5640 gaatgtaaag gtcttgacgc tcttctcacc aagagcaatt tacaagcgga cggtgtcacc 5700 aaagtggatc ccaccaagcc tatcggcttt caagtatctt atgaaatcca cgatccgaat 5760 gccattttaa ccaccggact tgtgattact ccagctacag ccagcggaga gatcgggcaa 5820 tttgttgaat tgctagcgac ggtatcccct gccaatgcca catatcaagg cgttaattgg 5880 tattctggtg atattacgaa agctgtacat gtcggtggtg gtaaattcaa attactggct 5940 tcaggaactg taacggttta tggtgtcacg gttgaaggga atcacacaga ttctacggtt 6000 attacagttg caggcgctct atcgctgtcg actgatttac ctgccaccaa agacgtaact 6060 tctggacaag acggaacctt tagtgttgtt gctgcgggcg gtacaactcc atacacttat 6120 gtgtggcatt tctctgatac tcctgggggt gcggggtcag ttatcgatgc tggcactaat 6180 gccaccgccg ccactgctaa cctggttatc acagcagttg aagccgcaaa tgaaggcgaa 6240 tattggtgtg ttgtttctga tgcagatggc cattctgtca cgtctactcg ttgtgaaatg 6300 gctgtggtgt aatttatgaa gagcttccag gatttccttg aagactcttc tgctccggca 6360 accacgaccg ccgatgtggg gaaacccgaa ggcggtatgg tcaaggagcc tgtcaaaaaa 6420 ccaaaagatc ttgaagaaga gtctgatttt aaaaagatct ttggcaacat tttcaaagat 6480 ttggatttat ccaaggcgcg aaaatggaat ttcaggacag gccaatacga cgattaaaga 6540 ggcttcggcc tctttttcat ttccagcatt gggtgtataa tggacccgtt ccccatgagc 6600 ggaacctaac tgaggatata ccaaatgcaa tctatgatca aacgtaaaat agaaatctcc 6660 atgaatgccc atgtcgatat gatccagcag cttgtggcag atgcgtatga gatacaaaag 6720 gaacgtcaga ttaggggagt gatagaccct atttgctccg gcaacatgct ctactacaga 6780 atgctccgcc agaccggaca tacagccgct ctgaagaaac tactttctaa aaagtttcag 6840 gtcgaaaacg acgcatatgt gtttggcgtc ttccatactt ctcgtgaacg tgatgcattc 6900 ttctatcctt cccgcaaccc tcagacgggc gaagaattac ttatccctga tgtcgacaag 6960 aaagagagca cgacgacaat cacccatttc atggggacca ggatcgataa ggctaacata 7020 atcgtgttct ctgacactct acatgatgta aaacgtttag ccgctgcccg tgaaatgttg 7080 caggatgctc ggaccagtct cacaaatttg actttagtag tgtttctggg ctagatatct 7140 gtgtggggag agaactcccc attttgaatc ggaggtgatt tatgttacgt tgcaagagag 7200 gttccaactc ctttaagttg ggcatgctga ctggagtaac gttcatgatt gctttagaca 7260 gccttgtggg actgctttcc ctacctgatt ttaggatgga acgattcata ttgttagttc 7320 tatttggcgg cgtctctatt atctgtaccc tgaaagcata taaaaagatt tgacctgatt 7380 acacacagca attttgattt gagaccctat atcatgctcc cattactcaa tgttccaaaa 7440 gaacgtatga cgccggatag tgaaggcaag acccattaca acatatacag tcgaagccgc 7500 acagaactag gcagattcct ttcccatttt gcataccatc ccatggatac tgttgatggt 7560 aatttcaact caatagaagg ctactggtat tggctaaaat atcgccacga cgacttgcgt 7620 agtctttatg ggaacgacgc caagcaattt ggacaaaccc tggccaagtc acgcatcgtt 7680 gtattgtccc ctgatgatcc caaatttaaa agagacatta tcgcagcgac gagtcaaaaa 7740 ttgctgacaa tgccatccaa gttgagattc caattggccc acagccgtct tcccctgatt 7800 cacgcttatg aacatcaggg gaaatacagt tttcaaaact ctatggattt tatcatacag 7860 catattaacc gcttccgtct agaaggatat ttgaaatgaa ttttctaaaa actatcttca 7920 acacatcata tgaactcagc cagcgcgatc ctaatcgttc tcctgtgttt gtatattgca 7980 aactcgtgga agagtcttgt gaactatcag atgtgcttta tggaatcgct gcatccgaac 8040 ccctgaacgg tgaagtggcg gacgttatca tctcggctct ggatctatta tatgttgtgg 8100 attatcaaca agttcaacaa catgggtcta tgaccaaaga agaaatcttt gactccatgt 8160 tgtttgcttt ggctacagcc aatcacacaa ctgatctcag ccaacatacg ttggaggatt 8220 attggttctg cagtggtgtt gaaactatag acaaatatct tgcgatggtt aatcattaca 8280 aaggccgcat cactcgttta ctgaaccaac ctcaacgttc agaagataat atggtggacc 8340 tggtttcaaa tctgatacgc aatactgcca aattggcgtg tggatataat caaaaccata 8400 tcaacacgat cgttaaagtg gaacatgcca tagaacacaa agtggaaaaa tggcgcacta 8460 aatttggtct ataagccaac cccatacata atcttgtgtg tttaccattg acgggatagg 8520 ccgatgtcca acaaaattga tattgaacgc aaatacaaaa agctcactca catagagcat 8580 atcctacttc gcccagagcg tcatctgggc agtatccgtt cgtctgtggg gacggtgtgg 8640 gtgtatgacc caaccaaaga caaagtcatc ttccgtgaca actttgagta ctcccctgcg 8700 ctgatcaaac agtttgatga aatcatcacc aactgtgttg accacagcaa gacccctgag 8760 ggtaaaggct tgacggaaat caccgtcacg gtctccccta tgaacggtca aatcatcgtt 8820 tctgacaacg ggggtatccc tgtggtcaag catggcgtca ccaatgagtg gctccctgag 8880 atgttgtttg gctcgctcta tgcgggcagc aacttcaacg atgaggacga ggagtacaac 8940 aaccagaagt caggcggcca gaacggtgaa ggggcttcgc tcgtcaacgt gttctcaaag 9000 tggttccgcg ttgctaccag tgatggcaag aagtcttata ctcagctgtt tgaagacaac 9060 atgagcaaga agtccaatcc ggtcatcggc aatacaccga aagagttcgg caccactatt 9120 gcctggatcc ctgattatgc gcgcctgggt gttaaggggc ttgaccagaa caacctgctc 9180 atgatttacc gtcgtgcatt cgaagtggcg gcatgcaacc cgcgcctgaa ggttgttctc 9240 aacggcaagc aaatccgcat tgatcgattt ggtcatttcg ttgattactt ctacgctggc 9300 tcggctgttg atgaaacgga tgattggtct gttgctatca ctccctcatc tggtgtgttc 9360 atgcatgcgt catacgtgaa ctcaatcgcc acgcacatcg gtggacccca cgttgattat 9420 gttgctgacc agatcgtggc ggcgatacgc cctcagctgg ttaagaagtt caagaccgaa 9480 ctgaagccag cgatgatcaa gaaccacatg tcattgttca tcgccgccga catcaataac 9540 cctcgctttg acagccagac caaggagcgc atgacgactc ctgtgagcca gtttggtacg 9600 tcctacaagc ccagcgataa actgattcgc aaggcgcttg agttcgtgac agcagggctg 9660 agtaaagaac tggcttcatt acgcaatgaa caagaagatg ccgaatttga aaaggcgaag 9720 aaggatatca gcaaacggga ttatcgtgag attgagaagt attatccggc gaccgccaga 9780 ggcgaccgca gtgggtgttc gctgctactg acagaaggtg atagcgcatc caaccctatc 9840 ctgaacgctc gtgataccaa gaaaattggt ttgttcccgc ttcgtggtaa gtttatcaac 9900 tgcttgaacg ccccgcgctc aaaagtgatg gcgaacgaag aattcaagaa tttatgcacc 9960 attcacggcg gtgctgtgcc aggccagccg cttgatatca gtcgctatcc acagaccgtc 10020 gtggcaacag acgcggatga cgacggcatt cacatccgtg ggttgttaat aactctgtat 10080 tgtacgttct ggcctgaata cgttcgtcag ggtaggctga agctccttcg taccccatac 10140 atgcgcgtgt ggtgtggtaa tataatgcat gaattcatga acaatgccga atatgaggag 10200 ttcctgaaga cacctgacgc caagaagatc acgaagaaga aatatctgaa aggtcttggc 10260 ggtaacagca ctgaagactt caagcgtatt ctaaacaacc tggatgcgta tactacgacg 10320 gtcacgctgg acgatggata caagcagtca ctgaagaatg gcttcggtga tgaggccgcc 10380 gattaccgca aaacctggtt tagcgacgtt tgcctgtttg aaaccgagga tgaataagat 10440 ggttgccaag agcattactg taacggactt tgtcaacact gaccacaagg agttttccgt 10500 ggtcaacagc atccgtcaaa tccctcagct gattgacagc ctgaagccaa gccagcgcaa 10560 gatcctcttc gctgctcttg aatacaacaa ggaggagatt gttgaccgcc ttggcatgtt 10620 cgccgccgct cgcacgaatt acaaatccgg tggtgagaac atgagcggta cgatcgtgaa 10680 catggctcag gggttcccag gtacgaataa catcccatac tttgaccgcg acggacagtt 10740 tggttcaatc atggggcgcg aagcgtcttc cgctcgttat atttcagtgg cagtgtctga 10800 agttatccgt aaaatcttcc gaaaggagga cgatgggata ttggaataca attatcttgg 10860 ggaagagaaa ctggagccga aattcttttt acccatcctg cccatgtttc tcgtgaatgg 10920 tataaatggt atcggctcgg gttatgccac cgacacccca tgtcactgcg ttaagtccgt 10980 gctcagtgcc ctgagagcac ttctccgtgg cgaagacccg aaggacttaa aaccgtactg 11040 gaatggtttc aaaggagaga caggctatac tgaggaagga agagcataca gtcgtggttt 11100 gttcacccgc gtcaatgcaa ccactctgaa catcaccgag gttcctattg gttggttctc 11160 taaaacctat gagaccaaag tgttgttgcc gttgtacaaa tccggcatac tcactgaata 11220 tgctaacgat acgaccgaag atggttggga tatcactgtt gtattcaagc ggggtgaatt 11280 gtctaagttg aatgacgaac aggttgaaca aatgttccgc ctctactcag ctaataagcc 11340 cgtgtggaca gcttgggatg aagatggtgt tattcaccgt tacgatggtt ggaaagatat 11400 gttgcttcca tttttcaatt atcgcctgag tcgctatgaa gatagacgtc agtatcttat 11460 caaggaattg accgacaaaa tacaccgttt gaacaatcgt gccatattca ttgggtgggc 11520 tgtcgttaca gatatgcgcc ggagcctcac ggaactgaaa gcgttattcc agacagacta 11580 tcctgatttt gatggcgatc tcgatgattt attcaagatg tctttatcat caattacact 11640 agatgcccgt gaacgtttgt tgaaccagat aaagaattta gaagttcaac gagaagaatt 11700 aaataataag caagacatcg atctttatac tgaagattta gatgatcttg aaaaggcatt 11760 gggcctataa atccggaggg tgaattccct ccaaacaagc aaggggttca ccatgtttgt 11820 atatttccgc agtctctcat tgctgacttt cttctattgg ttgttcgata tcttatgccc 11880 tcgttttatt aaagaggaag ttgcttttgt caatcatgaa ggtcaacaag atttatggat 11940 acctctttgc gctctttctg atgtaaccga atcggatgaa gtgggtatgg ttggcaccat 12000 gcgttcattt aatttatttg gattcgcatt attccctaag ttaattggag aattacaccc 12060 atacaatcct gatgaagaag tggaggcgtg atatgtcaaa attattgact ccaaaattat 12120 tatcaatggg tggttccata tattttcatt gtcctggatg taatatgctt catccttatc 12180 gcatttcagg gcaaatgcct ggcccaatat ggcaatggaa tcacgatctc gaatcaccga 12240 ctttcactcc tagtctgttg gtgaatcatt ctcatccggc gagtcgttgt catttgttct 12300 tgactgatgg taaattacaa ttccttggtg actgtttcca cgaattaaag aatcaaacgg 12360 tggagatggt tgatatcccc gaacctgaaa tatggataga ttagattatg aaattacttg 12420 gatattttcg ttctttacct actggatctc ctaatgggtg tcagttatat tctgaggtga 12480 aaggggacgt ggacgacact cacatcgcct tgtatactcg tgatatacct gacccaacca 12540 agtttgatcg gcgtgttgtg gctgctgcca acaaatatgg tgatgtgatc gttgtaagcg 12600 cccgacatca cgacaaattg atgaacacgc aactcaaacg attgaaggaa gcaggtatta 12660 tcgaaaccac ccacactcgt gaacaagggt ttattgataa ctatgggcaa tggatgtccc 12720 gtgaagaggc cgctgtggtc gctcgtgaag ccggacaaac taatcaggtc cgtttgaaga 12780 acactccttt caaagaactc ttttccgaag acctctattg aataaattgg cggtataatt 12840 gccgcctaac cccataatga gacaaataac atggcaaatg aaattggtga tattgcccag 12900 ttccgtgcta tttcacgccg cctgaaatcg tatggactcg tcatcgaaga aatagatgaa 12960 gatgttcagg gtgtattgga agggatgttt gggagtaccg ttggaacgga attatttgaa 13020 cttttaaaga tggcggctga taaccaattc gttgaatata tttctgaaca cgctattgat 13080 ggtctgaata aatgaacgag ttatatgaat ttgaacgcgt gtatgagtcc gcttcagttt 13140 caggatacat gaaacgatta tatcaagaaa tctgtgttcg tttgataatg cgaggaatat 13200 ctgtcaattg cgttatggca cagacagaca gttttattat gacactcact gaccatcgcc 13260 agaatatgtg tatcatccag gttagctgtg tcaacaacga aattatacaa tggagacgtt 13320 acgcatgacc acatatgtta tcacaaacgg cgatttactg aaagccgcta cgagttttaa 13380 tctcatcaat gctttcgctc atggcgcaaa ttgttggtct gtgatgggcg caggtatcgc 13440 caaccatgtt cgattagatt tcccagaaat ttaccgagcc gaccaattag atgaacgtgg 13500 tccggaacaa cgtttgggga acatgtccta tgcgtttgat catgacactg gtgtctgggg 13560 attcaatttg tacactcagt tctaccctgg tcctaacgca cgcatgcctt ccattatcag 13620 ttcagttcag attatgtttg aacaagttca cgatatcatt gaggcaaaaa ctgacgaaac 13680 agtctatgtt ggtttacccg ccatcggctg tggcatcggt ggattgaaac tgtttcatgt 13740 ggtgagccag attaataaaa tcgcggatac tatcttcgaa gataccaggc gtcgtgtcgt 13800 acccgtcttt tatatccgac agggtgacgg gtttgaacaa gatttacaag aactttccca 13860 gatggtggac tacggaatct ctgtcgtcgc tagtgaagaa gatatcatcg aagaggaagg 13920 tattggatga agcgtgaaat aacagaagag atgctcgcca aagccgttct tcatcccaag 13980 gtgcgttttg catttatccc tacacgttta cacgatggaa attgggtatg gctggagcat 14040 tatgttcgcg ctcctatcgg cctatatgcc caactccgtt atggcggcga agtcgagtta 14100 aaacaatatc gcgtcggcgg gggattaggc gggttggatg acggggaata tttcccacat 14160 cgcaatttcg ccatgaacga taattcatat ttcaaagtcg agtatgccac cgcttgtggg 14220 acatatcctt tgaaactcct tttagagaaa gcaggggaaa ctgatgtata aatctaattt 14280 cttggccgtc gctgatagcg aaactctcgg tcgttgggat gatgctgtca tgttgtcttg 14340 ggcacagact atcgccgacc tgaccaagcg ttatactctt cagcagcttg ttgtagagcg 14400 cacgacattt atcaaactga atgtcaaaga acagattgaa cttggccgtg tgaaagacca 14460 gggtactgtg gaatggtggc tgggtacagg taaacgcaac ccgtgcgacg ccgcccgagc 14520 tatcagtcta tatccgaccg acaaggatat ttctattttc aaattggccg atgaaattcg 14580 caggggatgc catcgccttg ggatcgaccc gcgatcggtt gactggtgtg ataggaatct 14640 gtttgacctc cgcaaggctc agcacatcat tgaggtgacg tgtaagcaag attccaacga 14700 accttgggac tatcaccaca catttgacat cgtaagctgg ctgaagggtg ttgggcagca 14760 ggatcgatat gctggtatca aggcgtggga actggaaggt atgatctatc atgaccctcg 14820 ttatgatgcg gcgcttgact ggctacgcat tcagaaaacc atggaagacc tgatggggct 14880 gaaggtggaa ggatgaatct ttccttgttt catggttgtt tacaatcata gttttcttca 14940 tagtctgtgt tcaatatttt ggaggttctt aaatgttctt tcaaattgtc ggggtgatca 15000 cgaccattgt ttttgttgcc ataacgcttt ggatattgta ttcttcattt atccatccga 15060 tttttcaggc tctcagtatt acgcgttggc tcacagcgtg ttctttgaaa tccggaagcg 15120 aatgtccttc tttatcgtcc aaatggaaat tcttcaaatg ggcgtatgaa gtcggaggag 15180 tccgaacaac cagatattca aataatgtgg gggaatggtt tagcatcggc aattggcgtt 15240 tgtacgaatc tgaagacaaa taagcccctt tcggggcttt tctatttgta taatgtatta 15300 tcattgtacc atcatatctt tatggcgcac aacaaatgaa agagcaagaa attatccagc 15360 attgtattcg cttaggaaca ttaaaacctc tctatcaggc tttgcgtttc aatgccatta 15420 aattcaaacc tttaccaaga actatcgcaa cgttctttgc catgcgttct gttggaaaaa 15480 cgattttctt tgagcatgac atttattttt atacaaagat taatggcgaa gatttagata 15540 aaatgatttt cgtgaacgac gataaaaata tgaagataaa agtggaaaac gaattgcgca 15600 ggataaatga ttctttaaga ggaatatttt aatggaaatt gttgtctcaa tatctgattg 15660 tgattttgta taccgtgttc ttcaagggga tgctccattg ccggagaata atcaagaagt 15720 gacgttgttc tggtctggtg gggtggatag cacatacatg ttgatttggt tgttatcgaa 15780 aggatattca gttcatactg tgtattgcca cctcgaaaat aataaattta aatctaagcg 15840 cgaaaattgg gcgaggaata aaatacacaa ctggattaat aaaaatgccc cacttctcat 15900 gtatcgttgg acacatcatc aagaacctat cagtagcatc aacgtcccga acggtggttt 15960 tcgcgcttgt ttagcacaag ccccgatatg gttattaaac acgcaattta aaggcagtgg 16020 cttgccttcc acgtatatct tggcatatgt taacggcgat gacgcaatac actggatacc 16080 cgcctttaat aaagttattg aaggatacaa catgatgacc agagacgggg aaagacctat 16140 tgaaatttta tatccattga ttagtctcaa gaaatcttgg ttctatcatc acatgtcccc 16200 aatacatgac ttaatgacat ggtgtgaatt gccaattttg aaaaagaatt gtgattgtcc 16260 tgcgtgtgtt cgacatcgcc atgagttgtc atagagatga aatgttcggt tgttgtaaat 16320 gacatcacga gattgataaa tcttatcaaa gacgtcttcc cacaacaggt ggatgttgag 16380 tatgttggga agaacggaaa gtgctatcag gttgctctgg ttctgaagca tgtgtatcct 16440 caagcagaga tccattatag ccagattgaa ggtcatgtgt atactctgat tgatgggaat 16500 tactacgaca tcgacggcat ccacttcagt gtcccaccag acacgtgttt gctcgaacat 16560 aatagaggtc acaaaccgca tcgttggcat aaagggtttg tgaacgtgcc gattttagaa 16620 tggctgagga aaccataatg gcgggaattg taaagcacct tggtgacact catcttgggc 16680 ataagaaggt ctttaaaccg cgtggatttg atacacagga agcccatgac gctgcggtca 16740 ttgacagtat ctttcagggg ttgaagtctc gggacgttct tgaactggct ggtgatatat 16800 gcttcatcgg ggctgaaggg ttcattcgcc tgatgcggga gggtgccaag cgaaacattg 16860 atgagtttaa gcgacgcccc gttcccgatg actggcgtcc gaactttatc atcaaggtgg 16920 cacaaggcaa ccatgacagc tttaagatgt tgttgtctct gtatctggac ggctggatta 16980 gctccttcgg tgctatgtat gaacgtgaca cgcctgttgg ccgtgtgttg acaacacatg 17040 ttccttatca attagaccgt tgggcgtata atatccatgg tcatcttcac gaaaatattc 17100 gagaagagcg cgaatacctg aactgcagtt gggaacaatt caagcgtcct gtaaccctgg 17160 ctgagttgtt atacacaaat ttaggaattg tattatgaaa atattctttc ctggtcagaa 17220 agtacccgaa gaaatagaaa aggtcgagtt atttggttat aaaagcggtg atccgttcct 17280 gcgattttct tcaccatgta tcgcatatgc gatcagctgc agcatatggt gtaaccagtt 17340 atgctcggcg tctgcaagtc ggttgtgtta tcgtaaaccc tgaaactgat cagcctgtgg 17400 ctatcggatg gaacggaacg cctcctggca tgccgaatgt ttgtgagatg gaacaacacg 17460 ggcaaattgt tacaaacccg tgtgtcattc atgcggagga aaatgctcta atgcgtatcc 17520 ccgaaaatgc agatgatttc acagggttgg ttatgtttgt gacacatagc ccatgccctg 17580 attgcactca gaagatcatc gacaatggca agatcgataa agtatattat caagagccat 17640 atcgtatcat ggatggaatc aaaagattga tgaactccgg aattgaagtt taccggatgg 17700 tgggcgatat ggcaatcctt aaacacgttt tcgacgatca aggcgaagtc ggatacgaac 17760 aaatcttatc caacccagac aaagtaagga attaaaatgc gttatgtaga ccgcatgctc 17820 ggcgaaaatg aacatgtcat cgctttcacc cgcccgactt ggtggagcgg tttttggatt 17880 tatgttctgg ttattttaac gattatccca acatttggat tcagtttgtt atttctgata 17940 ccaacaattt taaatgtatt gacaactgaa ttcgcagtca ccaacaagcg tgttattgtc 18000 aaacgaggat ttattcgtcg tgatgctgat gaactccgtc ttggtaaagt agaaaccatt 18060 aaggtggacc agtctattac aggccgtatc ctgaagtttt cgaccatcag tgttattggt 18120 acgggcggta ctcgcctgtt ggctacaggt tgttctaaag ggaacgaatt ccgtcaaaaa 18180 atttatgatc atctgggtga ctaaatgatt actgcaggat acaccgtcga tttgtattgt 18240 gagtgtgttg aatgcaaatc ttgtaattgg gcttgggaag aacatcaccc cagatgtggg 18300 atgaagtctt atgctggtga atcttgggga gactgtgcta gacaagcccg tgctgatgga 18360 tggatgatat gcagggacaa acaaacttgc tttgcccctg gacatccaag gaaatcaggg 18420 tagtaacaaa ccatcatctt ccgattgcgt tggttgttta ttagcagttt ccttcttcat 18480 ttgctctttc aacgcattaa tcctttgagc gcggcgtcga tcttccattt cgacttcgcg 18540 ctttttctta gaacgaagag caaattgttt tttaacttct gggtcttcac ctggcaccaa 18600 atgttcttct gtccagataa tgaatttcca acctaccttt gcgcaatgtt ctttagttgc 18660 tgtccacttt gcctgattta ccaaccaagt gcgcattgaa ttattgaatg ttgattcctt 18720 catcgtttta gttttgcgag gttctttaat ctggtctttg ggttttattt caataagagt 18780 aatttgtaat tcatcggaat cctgccgacg agtccaaacc ttcaaatcca tgaaataacg 18840 atgggcgcgg ccatcaaccg gagatatgta agggattaca gtttcttctg aagaccaata 18900 gacgatagca ggattcatat cacaaaattt aaaggcgaca agttctagcg aagaacgaaa 18960 tactattttg ttcacgtcgc ctttatattt cttgggattt acgggaacat acttcccctg 19020 caaatacata gccatattct agtcctaaat agtgtcatca ctctattcta attaaagggc 19080 ttcagaccat ggcgaatttc aagtcgacca tcgataagat caaagttctg aacacaaaag 19140 gcttggccaa gtctcagaag caattggtct atccattaga cataacaggg ggtaaaaccc 19200 tcggccatta tgttctattc aacatcaacc gaatatctgg ttcttcatat ggagacacca 19260 caacccaaac cgtcgaaaat ccgatacaaa atccattggg taagactcct gtggtttatg 19320 gttctaaatc ggggtctatt agcaaatatg cttgggcgcg tcatgtccgc tctaacgagt 19380 caattgtgtt gtgtatgccc gaatccatta caaccaacta tggcgttggc tggaacggct 19440 ccgagttggg attagcaggt atgggtgccc aatttttatc acgcgccgcc caagatatga 19500 gtcaattcaa acttggggat gctttgaatg ttggaaaaga aatggggaga tttgcggcaa 19560 caaaggccat tcaatctgct tcggaagcaa ttcctttctt gccgacaatt aatgctcatg 19620 atacattaga attgtttaca ggtacaatga ccaacccgta tgtggagatg attttccaag 19680 gggtgcgcaa ccgagaaatc ccgttcacat tcaaattcac tccaagatcg caaaaagagg 19740 cgaaaatggt gcgggagatt atccgtttat tcaagatgca catgtatcca gaatacaaat 19800 acaacaagaa ttccagcgca ttctatcttc atccatccac gtttgatatc acgttcatgg 19860 tccagggaga acgcaacaaa tggttgcatc ggatatcgac ttgcgtccta tcaaatatgt 19920 ttgtcaacga gacgcctgac tcttcatatg ccgtacacaa agatgacagt atcgtgtcga 19980 cacaaatcga catgacgttt atagaactag aaccgttgca caaaggccgc tttgataccg 20040 aaggcgacag cttctaagga gaaagatgcc atgaaatatt ttgagaaatt tccactcgtg 20100 tggcatcaat taattggtgt caaagaggat gaccaagtcc tgttgcagaa cttaacacga 20160 cgggttatgg ttgttaagaa aattagggac atagaagggc ttctcctgcc gtatactgtt 20220 ttcgatgggg aaaccccaag gtcttttgcc gaacgcgtct acggttcctt cgagctgttt 20280 tggatcccat gtcttatcaa tggtatcatg gacatcgcag aggactggcc gaaaccggag 20340 cgccgtatca ttgaagaact gacggctcga tacggccttg acggaatgtg ggatgtgaaa 20400 tactacgttg acgaattcgg tcatgaaaca gatcctagag caatacgttt agcatatggc 20460 cttggttcta tggatgattc cacgattatc gccaactatg gtctgacagg tattacatat 20520 catgatgatg ctataaacaa aaacgaagcc aaacggaata ttcaggttct agacccagat 20580 tatgtttctt cctttgttaa tcagctggaa caggagctga ccaaatgatc gaaaataaag 20640 aatcccagga cggaatttta actccgtcca caacatttga tttgaaatat atggcgatat 20700 taccgcacac gcctgaaggc ggtactccca agccttatga cctttcatcg ttgtttcaag 20760 aattcaacgt atatcaggat cttggtctgg aagggaatgc ttcaccgtcg ctgacagcta 20820 atattctgat caaagaaggc tgggatatat tggatacaat gccaatcctc ggaggtgagg 20880 aagtagtggt atcgttcaaa tcgcctgcag cttctgatta cactacgctt tcattgcgag 20940 tcagtcgggt ggggagagtt gctgacgaat cgaactcttc ttcgaaaaag gcattctggt 21000 tgcacttggt gacaacagac gcgtatcgag atagcatgtt gcgtaaatct gttggattaa 21060 gcggttctta ttctgagatg gcagctaaaa tctttgagca actgaattca cgcaccaaat 21120 ttgaagacat agatccttca tatgggatac aagaaaggtt cgctacccct ctttggcctg 21180 tactccgctc catagattat atggccagcc gtgcatatga cgaattattc atgccattcg 21240 ttttctatga agactttacg ggttatcact tcaaaagcat gacgacgttg ttcaaccagg 21300 gcaaccagtc tatgactgct gaagagaagc aagaggcttc tattgaaaag aaattcttcc 21360 gagaccctca agacgcgccg ttgatgcagg ataacaattt caactcagaa cgtttcatgc 21420 ggactataat caaggctgaa aagaaactgg cgcgtgatca atacatggcg aattatcggg 21480 atatcttggc agtgaacgag cgcgtgtatg actttagtac aaaatccacg acagcgaccc 21540 aacgcattta ttcagaatgg tttgacagca ctgctcacct tgatcctttc cctttgttct 21600 ctgatcaatt cgaccgcgag aacgttaggt acattgaagc gcaaccggat ggtgccgaac 21660 aaatagatta cgcacgacgc gttatagaat tcagcctcgc gtcaacggtt atgcgtttgc 21720 tggtcgtggg ggataaccgt ctgaatgttg ggcaggttta ttatattgaa gatttgtcga 21780 accgcccgaa atctaatgaa aacattgccg agttaagtaa gttatcaaca ggccattata 21840 tcgtcacaaa gatacgccat aagatttcac gcctgacaaa tgattatcaa tgcgtcgccg 21900 agattgccaa agatagtatg atccagaagg tcttaccgcc tcagactggt caaactgtgg 21960 cttctacacc aactccgacg ccaatagaga aaggacaagc ccagaaggtc tgagaggtga 22020 caaatggcag ataacaatca accgacacca gggcagcaag acatcgtcaa ggttttggat 22080 aaaatcaaaa aagaaatgat ggagcgcaag caattgcgcg cccaatccga gacgaataaa 22140 cagctcgcag atgtcaacaa acaactgcaa tctctgaaga cacgccaggc gtctaatcag 22200 gagcagaaag tcccgccaat taaattccca tcggtgaatg atattgttgg tgggtttgtc 22260 cgcgtcagtc ctattttcac aagggattac agcacttgga tgaaagacac cgtcagtctt 22320 tccaaggacg gaaatgaaga actgatgcga atcgcaacca aaatagaaaa atttggcgaa 22380 gcggcgaatg gtgcttcgag tcggaccttt ggctctgata acatctgtat ttgaattcgg 22440 taaaggtttc ttcaatgcta aagaaatcct tggcaaagcc caagtttcaa tagtagacag 22500 agttcaggcg ggcataacag aacttgttgg cagtttcgga gatctggctg attgggtggc 22560 tgaaatattt ggttgggata acgcaggatt tggaaaggcg ttccgtgaac aagtattgaa 22620 gatgaccgaa gcaccagtgc gctggctcaa ttctatcgtt gattgggtat ccaacgatct 22680 gtttgctggg atcggtaaag ggacagcact gaccgaaatc cctggtaaac ttgcagacaa 22740 cttacaaggc caattgataa aattggttga ttgggtaacg ggcgggatat caggattgat 22800 tgatgatggc atggcggctg caaataaagt cgttgaagat atgaagaaag gatttgcgga 22860 aaacgtgaag aaaccattct ttaatatgtt gaatgccata accaatgcca tgtttgatat 22920 cgtggataaa ttcgtgagta tcatacctga tgctctgggt ggtgaagcag ccaggaacaa 22980 aatggcggaa gcaagacagt ctatgctaat cagccaagac gataaggctc ctgagaatgc 23040 gtctacgccg ccaagcagcc aatcaccagc acaacccaat gccaatatca gcacgttaac 23100 tccgatgcct tctggggttt cttcggatgc tgtgaacgta acagatcgca cttctcaatt 23160 gaaagatgca tatgctggga tcgggggagg tactctgggc ggggcttatc cggttcaagg 23220 aagagcagcc aataacatcg aagaagttaa atccgcctat gctaaccctc cagccagtgt 23280 tgtggttcca gtacaacaaa atgtggacaa ctcgaagaaa gtcagtacga cgaacaactt 23340 caatagttca cagttggagc cgtccaaccg tactgataca gggcgcattc tctgggattg 23400 gtaatcaaat tccgtgggca aggattagct cacggagttt tccttttgtg tattctgtgt 23460 tttcatcagg aacaactgaa ttggttttct ttaataaaaa ggactcagag ttccaataga 23520 tgtcatcctt gagtattgta tcatataaat ggatgaaccc cactacttta ttcaatccaa 23580 cgagaaacca aattggatag cgtttaacaa taatatctgt cagtaaaggt ggatgcccat 23640 taccatttcc tttgatatat tggataaaat tcacgcctct ttcttttatc tcagggatca 23700 tatatctctc aaaatgttca agaaaattat atgagaagtt gtcatacagg cggcgatatt 23760 cattataatt ttcttgggcc tgtcttgtaa gtaatgttgt cacccacgtc tttggtgatt 23820 taacaaagtt ggcaataata taattttcca ccacttcacc ttgggacgat tcgaaccgac 23880 gagcaagttt agcaaattgt ttggccacgc cctgtttaga atagaacgtt tcaaacttgt 23940 aattgttcat cggtccatac aggccataat caaagtcttt tgtggtgaaa tgcaatttga 24000 tcgccatata gatgcaataa acgttgaatg ccctttcata ttgcattttc tcccactcag 24060 ttatcatgga gtttctcctt gcgtttctgt ctttgaagtc ggcgacgttc tgggcaaaac 24120 tggtagtact ccgacatcaa gtctttctct ttaatgaaaa gcatggcgtt ccggaaagcg 24180 atcccgattt tgacatatga cggcggattt ttaccaacca cgtgatctct cctctgattt 24240 aacgaaacgt tgaaactctt ctgtttttcc ttggcgatga ataaacacca acgccaaaat 24300 aaaacgacgg aatgattttg ggataagacg atatccgttg gtccaattat aaacgacatc 24360 agaacaattc atcatcttca tcatctgtaa ttcagaaact cccaattccc tcataatgtt 24420 tatgaggtga agagaatcat tgtctttcct tggtttctta tcaataagtt tcataataac 24480 acctggtaat gatttcttgg aattatactg ctactgtctt tattgaatgg ggttccgaag 24540 aaccccaatt ttcatgccgc ttccaacaac accaaaatat tttcgatata tgctttctgg 24600 atagcataga cttcagccag tgtattagcg actttcttgt ctgtgcgtac ttcaacgaga 24660 cgtggaagga atagagactt catggcgtca tcggttttat cctgtacgcc attagagagc 24720 acggcggcaa tcttaccaat gaagtcctct tggttttccc acattcgtag tctcaactca 24780 tccgagatcc ccgatacgcc aacaactaag aggccatcag aggtcttgca gaggagagat 24840 ccaaatgtct tggcgtgctt ccctttcttg tcggcctcgt tgaagccaac gatttcaagg 24900 tcacattcta cttccatttt cagctttaac ccttcagatg atgttccatc ttcccaaggc 24960 atatctgcgg ccttacaaat cgtgccttct tcccgacgag ccaaagcgtc tttgaagtgt 25020 tcgacagctt cttcaaatga atgaacgaca cgggtctcct gaacctgaac cagaccatcg 25080 ccttcatcaa acagttgctg tatgatatca aaacggcgct catatggggt gtccacacgc 25140 tgagcattga accaattatc atacggcaca acgtcccata cccgatagat caccttgtaa 25200 cgatcttcca ggggttcacc cgtttgaata acactgttga gcttaccatt gccgatggcc 25260 cgaggcaaca ctgtattcgt tttcagatca atgacaagca gttcaccatg gaagacgctt 25320 tcaccgatcc ccgcatcgta gatcaggtct ttgaaaacca atgacaggtt atcaacggaa 25380 ccacccgcaa taagagaacc ggaacgagaa cgaatctctg ggtctcttcc ataacgacag 25440 atgatgttgg cgaacatgcc atctgacttc agctggctga agacgccgcg cttgaagtcc 25500 atcttcttca gcaagtcaat cgtcatgtta tcataacggt gatatggaag gatattaatc 25560 agacgccctg taccacctgc tgcgttgaat gctgcgttta tacctttctc ggcaattccc 25620 gctttgatgt ctctgtcgag tataatttgt atcagggtat ggtaatccgg atggatgttg 25680 gttgcagcct tcgccagttc ttgatctgcc ttcatcccac cgatcttgcg ttcggccatc 25740 atatcgagaa catcataaac ctgatcccag ctaccgacaa cgccgtgcga gagcatgcga 25800 gggaatgcat tcagattgaa ttgagtgcgg taataagaac gcatcgggtc gtagacgtat 25860 tgaaggaaat caaccagttc cggattggtt ctgaacgctt cggtcaacac ggctttctta 25920 gcattagtgc ctttggtgtc acgaagattt tggattattt ctaagagagg aagcatcatg 25980 tgtctccagg gttattcgtc atgctattat aaccctagag acttcaatag atttatttgc 26040 tgcgtctttt tctgttgttc ggtggtgtgg cagaggtgaa agattccttc caactcttga 26100 atttttcaat cagggattct ttccccatct cgccgttgga aacatcatgg atataagcaa 26160 atgcgtcata cccatatcct ggtaaagcag aacagattcg aaggtgaacc aaagattctc 26220 ccacagaaac caaataatga tcgcgacgat cattcagagc ataatgattg tcatggaatt 26280 tgtcgataac aacgcagttc tggggttcgg cgtcaattgc cagcccgttg gcttcgctac 26340 cgccgcgccc aagggtgcat cctgggaata atgtttctac gagtgtggtc atattacttc 26400 ctcatcatat tcaataaatt aattttgccc tttgcttctg gggcatacca aacgttctga 26460 gagtgcctct tacagcacgg acaatccttg gtggcaatta cacagggagc cttgtccacg 26520 gcatatccag cgtcttcggc ttccttgacg gtgttaaatg gcaagtatgc acttgtgcct 26580 tgccctccgc atgaacattc catcagcgtt tcctcttaaa ggggatgatc agggctatga 26640 ttaacagcat agctgtgatc actccgcatg cgataagacc gaatgcaaat gctttcaaaa 26700 caaattgaaa aataatcata atttcctcag ttttgccctt gtgatctgag tttgtttaac 26760 acctttgaat tcggtcaatt ctttgacgcg accacgaatg atcatatcac cttccaggaa 26820 ttcggtttcc atataagaag tcttccatgt aatggtattg ccttccttgg ttttgaaagt 26880 atacagatac gtgtcaccat aatcagatga atacaggaaa atccttgctt cgaatttgac 26940 ttgcacttct aacatttcac caacttcccc cacccaattt gatacagaac gcgtttggcg 27000 cggggtgtga atataatcat aatactttgc tgctccccaa cgaactgtcg tggagtcctt 27060 aacgaggtga tatccaggtt cgcacatacg tttcaaccgg acgttgaaat cgttattttc 27120 agacaacgat gcgatgaaaa gcatcatatg atacatctct gattgagcat cttcacgggc 27180 tttaacagcc ttgttataga atatctcaat gtcagaacct ttctccggac gagtaccgct 27240 agagatatga ccaagaactc gaccaaaatc atcactttta atgctcaggc cggacagcaa 27300 aacctgaaag catttacgca aatatccttc tgtatcaaca taatctggtt cattaacccg 27360 ataaatccct tctgggtcat cttcatcggg ggtaaacatt tcgtgaatag acatgtaata 27420 agacataacc gcatcaaggg atttctgatg cgggacataa tgatgcatgc agctgctacc 27480 cacgagcatc tgtgcgccag attgttcgtt acgaacgaca tatgtgttat gacgacgcac 27540 agatttgttg caatgctcgc accaagatac gttttcagct tcgaatcttt gaacgaaatt 27600 tgggtggatg tcatctgaca gtttattcag aatgactttt ggatactggt ggttgaattg 27660 tccaataatg ctccacccgc cgtaggaaac ggggcggtcg atgccttcac cagtgagtgt 27720 acaatcctgc caccaccgat agaatttttc accagtgata gaatcgcgat gctgggtttt 27780 gtatggttcg ctgtattcga caagagggaa ctcgagattc aggcgcttgg ccgttctttc 27840 aagtttggcc agacgttcct tgacacgacc aatgttatca attgggatgc tgaaggtctt 27900 ggctttcatt tttgcctctc atgatgtagt gaaacttttc aatgtaggtt aaatgatagc 27960 cgcaagtttt attgaagtaa agttttattg aagtaaagcc caacaaatgt tgggctttaa 28020 ccgatattat tcatccgtgc gatcaggcgc ggcgttagga tacagcgact cataaagatc 28080 ttggtatttg gcgctggtct cgatggtctt ggtataagtt ccaccagcgc gatcggtaac 28140 gactttgcgc agatcaacgg ctttgatgcc tgtttctttt gccaattcag ccagggcttc 28200 ggtaacaaag gtctgttcag acttgatacg gatctgggcg gcacgacaat tttctaaagt 28260 ctgcatcatc ttttgacgca gttttggatc agaagggagt tgataaaaac caatttgttc 28320 aactgacata atatatcctc attaatgacg agaaccgagt ggaccgatac tagttcccaa 28380 acggcgcagg aagaaataaa cgatactgtg aaaaccaaac ttaggaataa tatcaacgcc 28440 ttcaacattg taatattcct gagtgttggt ctgtactggc aatggaaaag acggaagatc 28500 aagctgaacc aattcacctg gttcgcaatg tatcttgaca ttcttacccc aatgccgacg 28560 attcttataa aattctagag tctgctctgt agtgagtttg agactggttt ctccagactg 28620 gcacacctgt tgtgccgccc gaatcaggtc agctataaat gcaacatccg acatgatgtg 28680 ctcctgggtt aatattcaga tcatagagat tataccctat gatcaccatt attgaagtta 28740 accgaaattc caattattca cggtctcggc tttcttgaca tcatttacgt cgcctgtttt 28800 gtttaagtca tgtttgatat gaacattctc aacataacgg gcttcctctt ctgtcaggtc 28860 tcgcttgact tcattccaat ccaagtcaaa caatatctgt ttatcttgat ccataccgaa 28920 caagaacgat ttgagtttct gtttattggc ataacggttt ttcaagatag acgctcgggc 28980 tttcttaaca gccgccagtt catcgggggc atagaacgcc atgatgaagt ctgcaacctt 29040 cggaataccg atagcatctg ccaggtcgct aatatcacca tcagtcgccg attgtttttc 29100 acggttaaat tgcatacctg tccatacagg gcaatcaaat tcaaatccaa gcgcacggaa 29160 ttcacgcgcc accgacgtat aatacacgtt ggtgttctgc attaaatggg caggaaggcg 29220 agaagacgct gattcaccca agtagtctat aataatgacg tccggcgtaa ttcccgtgga 29280 tgtcgcgtaa tcaagaatat cgcggcgata cagtcctgta tgcccagcgc ctgaaggata 29340 ttccttgata acaatatcac ccttcatgga accgtcttga cgagttcgca acttttgtat 29400 cgtagcgaca tattcatgtc gtgagagctt ctctaaggac tcgaagtccc tgcgcatcat 29460 acgggcatca aggcggtgac gccagacgtt ctcagccact tctagggtga atacgaatac 29520 gttcaaccct tgctcggagt aaccagcagc caaatcaatc agagttgttg tcttacccgc 29580 attaattgca cccgtcacga tgttcagcgt tttcttacca acaccaccac gagtcgcttt 29640 gttgaatatc tctacagcga aaggaatctt cgcttcatta gagttcatgt ggtcgtattg 29700 ttgttcagcc atttcccaat agatatggcc aagataagaa tcaaaactta tcgccaacgc 29760 ctcttgtagg agagttggaa tcgtgttcat ctcatcttta cgtttctcat caccatagat 29820 gttgacggcg tgtttgatcg cattatgaac agctttctgc cgcgcccaac tttctgtttc 29880 ttttacaagc cattcctgat ggaatgtgtt gtcattgata ttctcaagag cagaaatagc 29940 ttgttcaaat acgtgttcgt tgagcgaagt cttttccagc ataatagaca acgcttcaac 30000 cgaaggacga gcattatatt cgcaagtgta atggtcaatg agaccgaata taattttctc 30060 gccttcgtta tcgaaataat cggctttcaa atacggctgg atctttcttt gatattcttc 30120 gttatagatt aattgggaaa gcacgacaga ttcgagtaac attggcaact accccaccaa 30180 aattttgttg taatcctgag cattttgctg tatcagatca actaagatat ccccagacac 30240 cacagtgaac aagtcatttt ctttcaaatt aacaaataac aaacgccatg gtttcttcaa 30300 tatatctgtt gtaaaggata accgaggctc tccattatct aaatggacac ccactttccc 30360 tatacgaaat tgaacgccac ggaatttgcc ttccgttatt tcgattattg ctaactgatc 30420 agaaccaggg tcgatgattt tgtaattaac gggggagtct cctccccctg caatattact 30480 cggttgtttt gatgacatta tcgaggcgct ccagcatatc tgcaggcata accgaactct 30540 gagagatacc gaacatgttg ttcacatcgt caacaaagtc tgggttttcc agcagcggat 30600 accagaagtc atcccccagc tctgccttac gatatttctt ttctttttct ggatcaaacc 30660 cgcctttggc agtgcgttga taccaagaac cactcaccaa atccacatac cccagcatgc 30720 gcgcaatttc taacataccg gaccaacggt caataccgcc ttcatacaac acagtgacag 30780 ggaacttggc tttttcacgg acaaagcggc ctttcataat gttgactgta aactgccatc 30840 ccaaaaggtc tttgtcttct ttaacttgag aacgcgtgat gaaccacaat tggttagaag 30900 acaggaaccc ctgtttaccg cctttgatgt tcggctcggc gtattggttc ccgatttcat 30960 catagtacga gttgatccat accaaaacga atttcttttc agtgaccaac ggggtgataa 31020 cacgccaaaa actattgaga gcgcgagcgc gggtcatatc ttgtgtgtct ttgcccgcga 31080 tggcatcatc aacttctttg gtagacggca actggctgat tgagtcaatg aatacgatga 31140 tcttgtcacc tttctgtgca tcgttcagaa gctgtgtcag cttgatcttc gtcttttcaa 31200 cgttttcaat cggcagatac aagacacggt ccatgtcaat acccatagat gtccagtagt 31260 tttcattcgc accgccttct gaatccgcga agatacaaat tgcatcagga aacttatcca 31320 tgtaagcctt aacatccacc agcccaaaca tggttttgaa tgtacgagaa tcccccacca 31380 actgtttgat gcctgatatc agaccaccat caatacgacc ggaccaggcc aaattcagaa 31440 taggaatacc cgtactgcaa ataatgtcag gcttcagcgc atcggtcttt gacagcactt 31500 cggcattcgg gtccagtttc tttgctgtct tgagcatgcg agccatcaat gaatcggcca 31560 tttcgtttcc tcttgcttgt tgatcgtaat taataaatcg gtgcccaaga ctttcttgga 31620 caatatattg attgcttcat gaatcgccat tattgacggg agtttttcat cgttaatttc 31680 ggaacccccg cgttctgtta aatacatatt acgcagacga ttgtgctgtg ccctgttgac 31740 acaagaaaca ttcaatgcga tattcaggat atacatcatt tgttcagttg taacatcctt 31800 tggaatagca tgaacataat atatcgcatc ttcaaaatag atatgctgta atgactctgg 31860 aatttcttcc ccgccaaaag caaaatcttc aatgcgttta aaaagtgttt ccggctctgg 31920 tgttgtaata tgttgcgtta cagtagccgc accatctggt tctttgttga atttggtcgc 31980 gataacgaca tgtctgccag gtttaataaa ctcagcaaag ttctgtgcca tttgcggggc 32040 gtgttccgcg taatatgata cgacgactgt aaacattaga actccagagt caaaggggtt 32100 tccgcggact tatcatagtt cgcaccgcca gcagcacgta gacgattgcg atcgttcttg 32160 cgcttgtggg ccagcatgta ggtctcagca tccagcccca aatatccgca agccgctgcc 32220 aagaaggtag ccaaaacatt ccgaagaggg tgtgacatga aatacgtgaa cagttcagtc 32280 actttcctga ggtcgtgagg ggtttgaatt ggctgcgcct gaacgaatct caccatttct 32340 ggaatatcgt gtggtttgtc ttcctcctgc aggacagcac agagcatgaa gtgaacaacg 32400 tccaccaact cgtatatggc atccacttgt cgccaatgct taccaccccc atagatcttc 32460 cagtctatgg ttgtttcgtc tagaaactct gcccactcac gatagatgga gtttgctatc 32520 gccacttcgg tccagcgctt cttccactct tccccaaaat aggccacgtt ggtggccttt 32580 tgaagttcga gcagactttt aatatgctct gctgtgatca tttccgatcc ctataaaatt 32640 tgacgaacgg ttgccaacct tcaaacggat tgacaaattc ataatcaact tccatcttat 32700 caatgaaagc ctcaatgtca tcctctatga taccaccgcg atccgccttt gaaatgcggg 32760 tgatgggaca tttagtgctc agcgcccatt catattcctg aggggtgcgc aaatcactca 32820 cgatataatg aacgtgtggg ttctgttcca ccaaaggaag ttgatatcgt ttaaagaatg 32880 acagaaacag gtctggttgt acgtaacgca agcccgtatc gctgccgaga tgaagccaga 32940 tctgccttgg ggttaatccc ttggggttat ctgggtgaac atatggcaag tccttgatgt 33000 cgtcctctac ttcctctggc aaccaaggat agatgtaatg agccacccga cgcaactcgt 33060 ctgagaaaga taagcgctgg atgtccatat caccctgtaa atggtgaaag ctgatgaggg 33120 actccaaaca gaagtccttg ccggagcgct tgcgccccgt aaagaattcc aaattagggt 33180 atttcattcc ccataccccc acatgtgttt acggtcaacg ggtgattgca acaacgcatt 33240 acgaagacca tcatcagcaa tccgacgttt atcaatttta gtatcattaa ggcgacacca 33300 cagacaatat gacatatcca tcatcaaacc tgtatctgcg ttatattcct tcaaatgctc 33360 tctgatttta ccaaattcac tgccaatgtc acagtgatga agtacaccga ggaacagatt 33420 ttggatgttt ttttgacatt tcaccttttc cgaagagaat tccaacaaag aattgtacat 33480 accagtagaa gttcgggtct tgttggatat gttcccgagt tgcttccgac tgacttcgtt 33540 gttgtaatag tgaaggttat tcgagaacag tttataattc ccgacttcca cgttcagcac 33600 cttcgccaat acttcctgca aaatggagaa ttcaatgaag ttgattgaac tcatacccca 33660 gaggacatcc tgacttcgat tgatgaccgt gatgttcaac cgcccttctg ttatactgaa 33720 caataaagcc agattacaga tcatgtcttt agtcttggct tctcctgttt cactatgcgc 33780 ggccaaactt tcatctgagt ccagagctgg atcatagatg gtgagatacg cctgacgggt 33840 gttggggtta ttgcgcaaac ggttgatgac actatccagc tggccatagt tgtacagacg 33900 tggtccgtaa gcaccacgcc acgttacgcc atcatccgag aagttgaccg cacgagggag 33960 gactcgggaa aggaaacgga tgtcattgcg gcctgacaga acccagaatg tttcaccaat 34020 cgcagcaagc gcagatgaat tacgaccttc aacagataac caacgatctc gagggtcagc 34080 caccgtaatc gtcacgccat caataaaacg agtgccgtca gtgttaatct ctgcgttgcc 34140 aggatctgac tcaatcccgt gttcacggat agccaacaca gctttcttaa gcatgtcatt 34200 attatttaga gcaaaaattt ccatcaatca atactcccaa aatcacgatt gagaaacgca 34260 aaaacagcct gctctacagt caggccatcg gacttcatca tacctgcggg aacggtaggg 34320 aacaagcctt tatgtcgttg acggtgatca tgaactctct cccacttctc gaccaccaga 34380 ctttcattga agtctgcgcc accgttacgc gatttaacac gggcaataca ggtttcaaga 34440 ggggtatcca taaagaggac gaccaattca cgtggtgggc gtgtcaggcg gggaatccaa 34500 gaactcaata atgtagacgg aatgatgcct tcgaaaatca catcatattt caggtattct 34560 ggttggtcag caatagacaa cgcgaacaac atctgctcag tatccttcag agaatcaacc 34620 cctttggact tagacttgtc atatttaccg acacagacaa tattgtaaga tggacaaacc 34680 gtgagcatga tcttactgtt atgggttacg acatacgcct gaggatcatt ctccgccaaa 34740 taagaaggca cagtagactt accactacca ttggagcctt taatgtaata caactctcct 34800 cgtgccgaat attccccttc tacagcaggt ggtttgacaa acaaatgcac agggcgcttc 34860 aacagccctt tgagcgaata agacatgaca tgctccaata aacaaaagga gctgctatta 34920 tagcagcccc tttatctatt gaacgcttct gaattaaatt acgcagcagc tttcgcttcg 34980 gccaacgcct gaggcaacca ttcattgatt gctttcacca gagattcggc atcggtttct 35040 ttgattttct ggcgtttggt gaatgattta ccattcacat acagactgaa cccccagccg 35100 ccggaaacga ttggcgccag atcaacataa gtattggtgc gggcgtgtgg attggcttca 35160 tctgccagtt cggtaacagg gaactggaac cagcgcatat ccggattcac atagctcaaa 35220 taaaccccag gcacaacccc tgattcaacc gcagccagga taggaccata attggatgcg 35280 cgagccgctt caaccatttc ttcacgcttg ttatgacgac gcttgcgttc ttcggtagaa 35340 gatgcagggc gcatttcaga agatttcttg gccagaaccg ccttcgcgtt cgctaaagcc 35400 tgatcatcct tcggattttc aacgtcggcg attgcttcag caacggttgt gcccagcata 35460 cgacggcgaa cttcttcagc acgggcttgc gcttcttcgt caagaacttc ttcgccttca 35520 actaccaggg aaatggaacc gtctttgttg acttcaagag aaccgtcttc gacggtctgg 35580 gaattttgat caccgacagg ttgcccaacc gtttcttcgg cgtcaatcac cggatttgat 35640 tcaccgtcgc cctgtttaac ccccgcatct tcggtcggtt taactttttc ggcttcagcg 35700 cggtcaagag cttcgagagt ttcttctttc tcttcctggc tcagaccttc aatgagttca 35760 aagccgttgg ctgactggag gacgccttcc atcatacggc gtaacgtgac gttgccgatg 35820 ataaggtctg cacctttgat ttctgcttga agatcagcag cggttttacc atcaatttca 35880 aatttcaggc cggactcgat atgaagaata taggacataa taaaaaccct tttgtgtagt 35940 aaccttcttt ggcagtctaa tgttcaactg tgcgtctgga acattaatat actgcctttt 36000 tagaagatgt aaaccacttt ttattgaaaa gttggttaac acttctgtgt tagacaacgg 36060 aacgctgtat cagcgcggac tggcgtgaat attaactttg tatatcaata ttgaaaactg 36120 tttcaggtgg ccacatggca gacaactcga tctgtgtgaa cttcggttga acatactgat 36180 ctaacacttc atcccagaga gcatgttcta tgttggcaat caacaattcg tcgtccacta 36240 tttcgacgga atgaaccact atccggtggt tataagtcaa agcatcgctc acatgatcat 36300 tttctgctct caggtgctgc attatgaaat attcgattac agattccagt accgtgttca 36360 ggcgaacata tttcttcata cagccccctg cttgtgctac agatagaaat taggaatttc 36420 gccggattca caaccaaacc cgttaaaatt ctgctcaacg tgtaagcgaa ttttattcac 36480 cactacctga cgatgctctt cttccataca acgttcaatc aaagaatacg ctgtgtatga 36540 cagactgttg aacaatctgg aaataacaag gcaattctct tcattgtaaa cgacttcagt 36600 atggattgcg aaagcgtggt cttcgtcggt aagaatttta cagcctttga ccacaaatgg 36660 tttttcaaag aaatcacgag ctgattcagt gccagattcc ggcattaaac ggaaatcacc 36720 ttcttcgccg aaaaccgctt tcagattttc tttactgaat tccgcttcca tctgtatacg 36780 tttgtcggca agatatttcg ccgcaaagta gaatttaccc actgcatcat tagcagcgcg 36840 gcggttcgta gcggcttggg tataaccaga aacgaaatct tcaatgaatt ccaatgcttc 36900 tggtttgcca aaacgaattt cgtcgcccag atccaagctg gcttcggaat caagttcaat 36960 gcccataacc ataagaagat ccgtttcatt cagcctgtgc tgattaaaca attgtccctt 37020 ggaatatccc aactggctac cgagttcata tccggtttta ccacccgaat ctttatgggt 37080 gcgatcatag cgaacgcaat tagaactgaa ttcaatacca aaaatacgat gtagctgtga 37140 catatcataa cctcatgttt atagaaagcc gttcgcgaat tatcacgtag aacggctttt 37200 agaactaacc atttttgtgt ttacgacgtg cgtctttcca aacagacatc tggctctgtt 37260 tctggaatcg agcagtgcgc ataaacaaaa caacttccca gtattgaggc tcaatctcat 37320 aaagctgtga acgaaattga tcagcgcggt acagtttcac acaatggttg tacagagggt 37380 gattggcgaa ccgtttcagg gcatcccagg taagtctcaa acgagtttta gaacggtacg 37440 ctctttcgtt cctcaacttg ataagatctt caaacactaa taatctgagc tttggtggca 37500 aataatgaag gttgagacca taaagatagg tcacaccacg ttcaccgaat ttcaccccat 37560 cccccttcac aaaattgaag aagaacacca gaggatacat atcccaatac gggagttcat 37620 ctttagtcag cgcatcatat ttgaaataat acatgcgacc aacaatataa cgcacaccct 37680 gaacaggacg tttattttca gcgaatgctt tcatcatgtg attcggagat aagttagcat 37740 ctttcgacac acgctccata aaccacacat gagaacgacg gatattacgt ttcgcttccg 37800 gcccaaaatg ttgacgatat ttgcggatgt aacgcttgac cagttctggg gcgtccatct 37860 cggcgggaag caacaacggg tcttcttcac ccatagcgtt cttagccatt tgtcaactcc 37920 ttataaatat caacagatat attatttaaa tggagtcctc atcgtggaag actatcgcaa 37980 ttttctaacg caactgcttc aacggggtat ttcccgcaag aacagatttc gtgttacaat 38040 tccgttgccg cctggaatat ttgattccaa tgcgacacta gcaaatgatg ggaacgcata 38100 tccttcatct tcattcggcg atttattcaa acaaagcgcc cgtattgtaa acgcattctt 38160 tggagggaca aaccaaacat ctcgttccct gcaaatgatg tgtatggtcg catctttacc 38220 tggtacaggg attgacacta ctcccatgac caacaacggc aaccacatta aaatgccgaa 38280 caacaagacg aacattgatc tggagttgtc gttcctcctc gccaacgatt attatgaaaa 38340 gtcggtcatg gacaaatgga agaatctgat attcgaccca tacacaacca agatgggtta 38400 ttatgaagat ttcgtgaccg atatttgtat agagcaaatg gatacagaag atcaggttgt 38460 tcatcgcgtt tatgtgactg aggctcaccc catcaacttc agttctatag atctggataa 38520 aagcgccgcc gatcaattta atcagtacaa catttccttt tcttataaca aagtattatc 38580 ggagactgaa tatgaaacgc gcagcctcgc cagcgatttt cttcctttgg gtattactga 38640 tgctcttgct tccggagact gggaaaccgc tgcgtcaaaa gccggacagc tgtataaaaa 38700 gatcaaagaa ggaaacttca caggtgaagc cctgctggct tataagcaac tcgatcagct 38760 tgtaaacaat ctggctggta tcagcctggc tgatttcgaa aggatctcta tcggcatcca 38820 gagggatatc ttaggcaatg ataacctgac ggcgtctgag aagagtagtc tgttgggatt 38880 gttacaggat gttgtcaaaa actaaaaagc ccccgaaggg gctttagcga aattagtctt 38940 gcttcaggaa ctgctcgaac tcatcaatgg aagccgtctg tttcgcatcg gcaccaccat 39000 tattggctgg aacagattgc tgtgcattag aaggctgaga ttgttgttgg ttcagacttt 39060 cctgcgctgt tgggcgctgt ggttcctgag actgggtagg cgcatgtgcc atagtagaag 39120 caccaccttc aaccagaggc tgattatcag ggatggccag aactttgcgc aaacgttttt 39180 ccaaatcttc gtacgatttg aagttggccg gattaaagaa ctcaaacaag ctgtgctctt 39240 tttcccagat ctcttcaatg tattcgtcgg ttcccagcgg tgctggatta tcccacttca 39300 cgttggtgaa gttggcaacc aggcctttcc agtttccgaa ctctttctct tcgccgtaca 39360 gattcagaat cagattcgcg ccttcccaca tatcgaacgg gtcgaatttc gggtcggttg 39420 agaacttagg attctgagcc gaatccagga ttttcttgac ggcattaccg aactcaagca 39480 agaagacctt gccgttgttt tccggattgt taccatcttt gatcaccagg atgttggcgt 39540 agtatttggt gtccggcaga cgttttttga gaactgtttt cagcttttca tcattcgttt 39600 ctttctgttg tgcccacaga ggacggtcat ggtcacgaac aggatcatcg ttaccgaaag 39660 tctgcggaga gttttcgata taccaaccac cagcgccctg gaatgcgtgt ttcatgatca 39720 tggcacacgg agttaacaca gcatcttcag ggatggtgcc ttcttcttta gccttcatgt 39780 ccaccaaagg gatcgacagg aaacgaatga tgttttcaga agtacccttg tcattccagg 39840 tccacttcca gatgcgtggg tcacgaccgc caccaacacg ctggccttgc tgagcgagtc 39900 gctgttgcat agcttcggct tgttggccac gagattgttt aagacgatca aataaattac 39960 ccattttaat attcctctat aatccgcccc ttcgggctat tctgtaaatg tatttgtcaa 40020 ttattccgac ggtgtaatta tactgcgttt tgctattgag ttaacccgca atcatttgtt 40080 ttgctgggtc tatttcaata atgtcgtaca catccgagaa ggttttgtgt ccttccaaga 40140 atgtatggta ttcgatgaca taggatttac cttccggcgt cgtgtaacgt acacgatcca 40200 tatcatcagc atgttcattg aggctaccgt gacgccagcg gatagaacct ggcagatact 40260 cttgcgcctt caacatttta tagatttgct ctttgctcat gttacaacct taaatgagtt 40320 ttttagattt caattcaccc ttcaacaacc gagcatcaga acattcagct gttagccttg 40380 acagaagagg aggcgtgatc aattttttga cctttgcttc ttcgatgtca tactcttcac 40440 aaacactggc catcgtttca aggattgatt ccttgcgttg gcttgctctc atcaacacca 40500 attcggaaaa agaatctggt gtgagcactt gtgctatttg ttgatcagac atcgattgta 40560 ttccccttcc ctgattgctt cttaatatga cgcaaaacgt ctttgaagcc atcaggcgcg 40620 gactgaggac cacgaacacc agatacgatc tttggtgctc cgataatcat ttttatttcg 40680 ccgccacatt caaaacatgg ctctaattca ggcgtgtgac gttcagcaca agattttcga 40740 gcactaaacg aatttccaca acctgtacag gcataatcat aaaacggcat gaatcgcctc 40800 caatacgtgt cgtagaaata taataactgc tcccaccagc gtagaaaaca ggacaatcct 40860 gcttgcttta tcacgcagca aaacatattc ggccaacata tcagattgat ttgcagctct 40920 tacattgacg tcactatgtg gtgaaaccgc atagaaagat accatggcac ttaatgaatg 40980 aaggaatgtc aagaatccct taatccaaac aaacgccgtc atcaacagca aggcgaaaag 41040 cagtatatct gccagcagcc agtagttaat catttcttac acctctattg aaatcaggat 41100 aattttctat gaagtaagga ccagaaacca tatttgcaaa cgaatccacg aggtcatcga 41160 ttggctttgg atccttcaca tccaacatgt ccattatacc gcgcatctta acgttgaaca 41220 gcttctcaaa gtgatctatc atgaccaatt tgtcggcatt tcctttacca caaaaatgtt 41280 tcttaacaaa agacggggta acaatctgaa attccatatt gttacggcgc atcgcttgtt 41340 tcaatagaga tgtgttctcg gcggtttggc atatgttatt ggagtttttt gaattcccca 41400 tagcatagcc ttctagggtg atgaaatccg gcttctccgt aagaagtacg gcttcagccc 41460 atttggaaat gttataaaac cgttcttcgg gggattcata tttgggttga cgtaaaataa 41520 gaatattgtg tcgcacttga cgacagtgct tctcaacggt atggtgtgca tagaaatgaa 41580 gatgatcaaa atccagagga tctttgtcgt cccagaagca catggctgga cagccgtaag 41640 aatagtcgat tccgcaaaat ttcataaaaa tacccataac gaagtttcat tgtgttacgg 41700 gtatttagac cggattatct ggtgacgatt ttgctttccg gtaaaatcag gcgaggtttg 41760 gaatccattt cttcttgaat ctgacgtatc tgttgcagta atgcagaagt gtccacatga 41820 cgtttgatcc ctcgcgcctc atcaccatat gacacatggc cgttggcgtc cacataatgc 41880 gcggtgcaaa ccatcaaaac ataacccaac tcaccaacgg caactgtcag atcaaccact 41940 tcggaagcca aagactcacc atcaacactg agattgggag aataatggat tttaccatca 42000 gccataaatt cgctattcag cataatcatg ccagcgatcg tttgtacaac ggggttcccc 42060 tgatcatcgg caacgaaacc gtcgaatgcg ccttcaaacc ctggcgcaat ttctcccttt 42120 tcatttgtga tcacagcgcg aaggcgttga aggatgacgt cttgtacctg ctgaatatca 42180 gcgcgttcta cgtttggcat tattgttctc cagttcataa tcccgttctt taacatattc 42240 ataaagacga gaagtaattc ggtcggcatt gcctgtggta ttcttcacaa cccaaccgct 42300 cgtaaggaca tccattttat atccacaatc attatcttga aaataacttt taattgtttc 42360 aagacgacga cgtttatgaa aatacggtat taattcaccg atgatgatac aatccggata 42420 gtgtttgtcc agggtgttga tatctcgttg cacccaaacc ggaataacat catcctcttc 42480 aattgggctg tacgttggat caacgataat cacattgaat ccataattca ataaatcttt 42540 aactcccagc cacccgaatt tcatatcgga cacggtcatg gcgacattct ttatccccaa 42600 tttatttgca aaatctgtga gtaatacaaa aaagtccgtg tttgcatccg gataattaat 42660 tgcgagttgc tcccccactt tactgaaaca gaacgcgtgc attttcagtc ctcgttataa 42720 atacaattac aatataccgt ggagatacat tatgaattta ccatcattgc ccaaaactga 42780 gagaacacat aaaagtgatt tctggccgac tgtgatcaaa taccgcgcct ttacagcagg 42840 gcaacagacc atgttacttc aggttgctga tccgaacact cctatgagtg agcgcgtggc 42900 aacattggag caactatttg acagttgtgt tgatgctggc gttcccttta gtaaactgcc 42960 aatcggtgtt actgaagaag tatttttaaa gatgcgctgt atatctatcg gcgaggtcat 43020 gaagatacgt tacaaatgta ataataaagt tcaagccgaa accaatgaag gtggtgaaga 43080 accagtttct ggccttaaag attgtggtca agagcttgtg ttaccgatcc cgctcaatca 43140 agtaaaatgc gtgtccccag aaggcttcag ggagacgttt gatctaccag gtggttatca 43200 tataaagatg cgccagccgt ccttctcgga tgcctcagtg cttaatgaag catcctctgt 43260 tgaacaaatg attgccacct ttatcgattg tctgtatgac gacgatggtc aggtttggaa 43320 ggtggaaaat ccggctgaac ctggtatcga tccagaagtt gctaaagaac gccaacgcat 43380 taaggatgaa tttgtcaaat gggtcgggga caatattgaa tctgagattg ttcaggacat 43440 ttcggatgat ttctttaaaa agattccgcg tattcgttac gcgacaaaaa ttaaatgccc 43500 ttcgtgtggg aaagaacacg aagtcaaatt taacagtgtc accgagattt tcatttaatt 43560 tttgaaattg atttactctc ctattttgtg atgtgtgacg aattaaaggc acacggctat 43620 agcatatttg aaatcagtga atcgatgccg tggcatcttg atttgcttac tgagacactg 43680 aaaattagat tgtctaagaa atcttccaac cccacgtaat gtggggtttt ctttgcttac 43740 ctgttttata ggttaagaca ggaacgttta accttaaatt gctataacac cgttgttgct 43800 gaagtaagtg ttgtgcaatt ggggtttgaa tttgttttga agcaaaaata atccttttct 43860 acgcatgttc tgaggtgtac agtattttcc tcgcctttat gcctccatgg cattggaatg 43920 ggactgcctg tcaaggcggt gttacgagct tcagcgagta ggaacgaaaa gaataaaggt 43980 tgaacggaag cagagcttcc tataatatat tattcgatag atttcaaatc cccgccataa 44040 atatcacatg attctaattg actaatgggt ttcaatatgt tagacaactt gcgttggttt 44100 tacgggcgcg ttgaagacgt gaatgatccc gatcaaaacg ggcgcgtcgc agtacgcatc 44160 tatggggtac acacggagga taccactctc ctgcctaccg aattattgcc ttggggtaaa 44220 atgcttatgc cagcatctaa cgcctcctcg gcaggtttag gctggtctcc gacgggtatc 44280 actgtcggct ctgacgtcat ggggtttgct ttggatgaag catatcagaa catccgtatt 44340 gcatgggtat ggccagcagc aacaccaaca gatgggtcag atacaaaccc attggcgctg 44400 ggccaggtcg ttcaatctat agaaaggcag aagtataatg ccgtcgagaa tgttcctgtt 44460 aagattgagg atgaaccaca accggatcca caaccaccag tagacggtta tgatcctgag 44520 aagtggatga ccgtggctcg tggggaattg ggcgtcaaag aatattctgg taagttcaat 44580 aacaacccaa ggatattgga atatcataag acaacttccc tgggggcgtc agaagatgaa 44640 gttagttggt gtgcgtcgtt tgtcggatgg gttctgatac aggccggata tacatcaaca 44700 cgttctgctt tggctcgttc atatttacaa tgggggtctc ctctgtcaga accacgttac 44760 ggcgctgttg tagtgttccg gcgcgggaac aacccgacat tcggtcacgt tgcattcgtt 44820 cagaaatttg acgccaacta cgtttggtgt atcgggggaa accaatccga ttctgtgaag 44880 gtgagccgtt ttagccgctc atccgtgttg ggttatcgtt ggccaggtcc agcaactaca 44940 gcttcagcag ctccggcaca acaaaacggt aaatggtctg aacctattcc agatcgtacc 45000 ccgaaagtcc aagaaacacc gcctccttct ggtcgtgttc aggatattga caacacagga 45060 gaggtatcgg ttccttcggc tggagggtct cgttatccat acaacaatgt tatggcttct 45120 cgagctgggc atattatgga ggtcgatgac actccaggcg gggaacgtct ccattggatg 45180 cactcctcgg ggtcttataa gcagatgctt cctgacgggg acgtggtcaa taaatcagtc 45240 aaagatcatt atgatctgac gatgtttgac aaacgttatt atgtggggcg cgatcataac 45300 ctgactatcg gcgggactga agtacagcgt aagacaggag aagtttacca cttgcactct 45360 tctaactact ccaatgtggt cgctggcacg gcgttgatga aattttccca attggctgag 45420 atacaggcac agaacgtgtt gcgtctcatc tgtgaaatgt tggaagtttc caatactttg 45480 aaagtgccta aaatactggc tagtgaaata gtttgtgata agttgtcggt ggcgcagact 45540 attgaaggca acatcaaata tgctgaaggc gctggccgcg ccgcctcacg tgcgggggca 45600 actcctgtaa caactacagg cccaggtcca attgatataa aaccggagtt agaggataac 45660 ggtggcaatt ttggtggtaa aggcgcatga ttacactggt gagggcagat aatgccctct 45720 cgtgctggag aggcaatatc caaaggggtt taacatgaaa gagtacaagg acattgacct 45780 gaagtttggc atgcatccgg tcaccaaaga tgtcactaag aaaacaggca tttatgctgt 45840 actacaatct gtgcgtaata tagtgatggc gacggtaggt gattggccga cgtatccgag 45900 tattggggcg gggttgtata ccatgctggg agaaaataca aatcccacga tacaggtcga 45960 cgtgaagaac aaagttgaag atgccattgc tctttttgag ccaagagctg aattgcaatc 46020 tgttgatgta tcattgtcgg acgattatca ttctctgggc gtaaccatca cgttctatgt 46080 ggtcaacaac ccagagccga taacagacac catatggttg aaacggacaa attgattaaa 46140 gaacgtccgt ggcagagcat tttgtcacca actcaaaatg agttaataaa cgatataata 46200 ttttcccacc cgttctgtgg actatggtgg ttggctttag gttaaccacc acaccgtcca 46260 gattacctgt caacacaaat gttagacgga tgcgcaagac gtcggtgcct tcagaacgca 46320 ttatttggca gtcatggcta tatcctattt gctttccctt tagaaccaga gggatacgga 46380 ctttttcctt taacagaata tccaaatttt caaataaagg ttcttctttg ttattgacgg 46440 aatacaccgt ctctaatatc gggaatttgt acatatcacg gcaccaaagt aatgacgatc 46500 atattgagta ctgtatcaac cgcgatacca gaatcttctt catggatagt tgatgcacgt 46560 aaatgaatgt cggaaatata attgtctatg tgcatcgacg tcaaataagg acggtgttga 46620 tacacaggac ggttgacctg aacatattca cgcagaatgc tgaatgaaaa gtcttcacat 46680 tgagtggtgt caatgcgcaa aaatctttga gcatggcagg tctttaactc ggtcactttc 46740 cccaaataat ggaggtctcc ggatgaaccg atgcggaaca tcacgtctac ttcagatttg 46800 aaaatttcgc gttcaataag ggtcgctggt gcccaacaaa cttcttcctt gtcttctggg 46860 aataacgtat cgatcacttc aggcaattgg atgtaaccga agttgtgacg agggttggtc 46920 agtaatttgt tagacatttt gtgctcctat tacgtgctcc gaggcttgtt cataagctgt 46980 acggagttca agataagaat ctgccaataa cggtgatttg tcgtttttcc gattcatgat 47040 tatttggtgg ttaacgacag cacggcgtaa tctgagttct gccacccaga atgctttttg 47100 tttggcgtgt cctggacggg cgcgtaggtc gtgataatgc atagaagcat gatatatttc 47160 agagttggtc atgatgtagt acccgctttt aatttgtggc gttggccaat gaattactgg 47220 gaagtatagg tgggaaggtt tcaaaagtaa agcccctcat tgaggggctt caaatttact 47280 ggattttact gaatatagag agccaacggc aagttcgtac cacggtcgat cacgtataaa 47340 agttggttgt cttttctgaa cgtgaggcat tcagattgat acagtaattc tgcatgtcta 47400 gcattatatt gaaactcttt gtataatttt tggtcttcag ataaacattc aggatcaatt 47460 accataacgt ttttcgagcg catggtctct ttgggtaaca cagcgcctcc atggagggca 47520 tcacgcaatg ctctgataat agagcggggg tactcctccc caataaccgt gaacatatat 47580 ggtacatatt gtttaaacgg tagggataaa gccaaacctt ggatagggaa agcggtggtg 47640 gcgtctagca taatatggga attcagatcc atgatatagt ccttctggtc aagtaaggcg 47700 ttgttgccgt gacctagaat actataaaat gttttttgaa aagtaaagcc ccccgtataa 47760 tgggggcttt gaaagatcag cgtttcaaac ttgcggcgag tccagtaacg tcggtcacgg 47820 tttggtcagc cagaacaatc acgggcatag acatgcgttg cttaccagtg attttctgta 47880 attcttccag cttgtagtct ttgtctagct tcagaatttg gtgttcaata ccgcgaatgc 47940 gacagatgtt ttcagcttgt aaacattgcg cacaaccttg tttggaataa atcgtaatca 48000 tttctcacct ttaggcaaat ttcagaccgt cggagactga tccagtaagg acaccagtca 48060 gataatcagg ggcttccgct tcctgtaatg catattgcat tgttttatta tctagccact 48120 catttatcca tggcaccgga ttgtctttac gggcttgtcc tggatatggg tggccaatgg 48180 ctcccatacg atgtgttgcc aaccagtcca ccatttgatg aaggatattt gcattcagtc 48240 ccagcattga gccgtctttg aacagataat ttgcccattc tttttcttgg ttgacaacgt 48300 cgacatacac ctgggtcatt tcgccgcgca gttcttctct aataatggca aaatcagggt 48360 ccatcagtgg cagacggttc aggaaagtct gggtcaggat gaggtgatct tgctcatcac 48420 gagcaatctg acggatgatt ttagcgttgc cctccatttt gttgaggaat tgcatgaaag 48480 cccaagaaca cgcgaatgaa acatagaaac gaacgccttc gagggagtta gcagcaaaca 48540 gagcacgcca gaatgcacgc ttggcgttca tgatgtcttc acgggtgaac gcgcgtccag 48600 ccatacgcat cccgctgtaa cgcaccatgt cgtcgtagta tacgctgatc tgtccggcgc 48660 aatcgacgat ctcctgaacg tccagaacat ggtcaaaaac gataccagga tcattcactg 48720 tgttacgaag gatatgcgtg taagatagtg agtggatggc ttcttggcgc gtccactcca 48780 gaatagcaaa ttgcgcttct ggtgttgatg cccatgggcc aaacgcttcg aacggagcag 48840 cgccctgaat agagtccagc atggtttggc gtttcaggtt gctgaagtat atgtgttgtt 48900 ccgcagcgga tagagtggca aagtccgctt tgtctttggt gacatccact tcttccggac 48960 gccagaattg gctgaggcct ttttcatacc atttttgaac aaaaggccaa gccactttgt 49020 cataacgctg gatacttaca gggtcgccaa agaacggcaa acctgtatta tctgaagatg 49080 ggtcaaatac tgaaaattgc ttttgttcgt tcatgtttct ttcctgatga ataaggggtg 49140 acgaatcacc cctgatatta aacgattgtg tggtatagac ctaatcaaac aacacaggtg 49200 tcacaaattt cttcaacttg tttcagctcc tcgtcttcct tggagtcttt gttggtgttg 49260 taatacagag ttttaccacc ccacatgtag aaagacagaa tatcctgcat cataagagag 49320 cgcgggatct tgccttctgg atatttctct gggtcatacc atgtgttggt actgatagat 49380 tgatctaccc aacgttgtat gaccgcagcc gtcttcaggt attcaataca atccagattc 49440 catttcaggt catatagagg accaagggtt tctacatccg gaacgatctg tttatagacg 49500 ccgtccttgc tgcctttgat gctgatgaga ccttttggtg gctctatacc gttcgttgcg 49560 ttcagcacct gagaggagct ttcagttggt gctacggcta acaacgtggc gttacggatc 49620 ccatactctg ataggttctg cttaagacct tcccagtcaa gaccataggc ttgcccaaca 49680 ggctttttgc cattgggtag gatgtccagc gggagaggct gaaggtcggc tgttacaaat 49740 ccggaatcat ggatagttga cttcttacaa gatccgaaac gcatggccag acggttggac 49800 gctttgacca agtagaaatg aagatgcgcc atccacttgt ctagaagttc taatccgata 49860 ggcgatccat aacccgtgaa attcttggcc aggaaatgtg cgacgttgac gataccgata 49920 cccagaggac gatattcttc tacggccaaa cgggcttggc gagctgggta gtcctgatat 49980 tccaacaaca tatccaaagc tgaaaccaga acgaaagcaa catcttccat ttctgttgga 50040 tcttcaaatg ccgtcaggtt aaatgatgcg agtgtacaca gggcaatgcg accatcttca 50100 tcatcatact gttggaactc acgagtcgga agcgcgattt ctaaacacag attagagcta 50160 taaatcgtgt ccaaattgaa cggactatac tcgttcatgt gatcaacgaa tgcgatgtag 50220 atccgtccag tgtcagaacg ctggtctagt agcatttgga acacttcttc agcttgcagc 50280 tttttggaac gacataatcc ggcgtcggcg gccttgatca tattgtcgta catttcgcgg 50340 aatttattga cgtctgcgaa aaatgcttca tacatttcgc ggttgtcttt tggatcaaac 50400 aggtatagag gctgtttgtt caccaggcgc tcgaacataa cgcggttaat ctgaatccca 50460 tagtcgatac ggcgttcacg gttctcttcc aatccacggt tgtttttgag aacaacgaca 50520 tcatcaaatt gataatgcca gatgggaaca tagcatgttg ccgatccacc acggataccg 50580 ccttgagagc aagacttcag ggcaccagtc aaatacttga tgaatggaac cagacctgta 50640 tggaccattt cccctttacg gatagggcta ccgatgccac gaattgcccc aacatcgaat 50700 ccgatgccag cacgtttgga aacataatcc acgatgcttt tcgcagtggc attaattgag 50760 tccaatgtat caccagtttt gatcaataca caagagctga actgtcgggt cggggtgcgg 50820 acgccggaca taataggtgt tggaagactg aatttgcctg tactggcgta ttcatagaac 50880 ttcttcacca ttgtcagtct gctttcttta tcccacgctg agaataatgc catagcgatt 50940 gccatgtaca tgacttgagg ggtttcataa tacactttgc tgtcagaaga acgatcacgc 51000 aaaagatatt tttgagtcag ctggcccatt gctgcccaag tgaaattctt gtcgcgtttg 51060 tggttgatga ctgtgttaag ttcttcgaat tcttctttag agtaaagttc gaggaattcg 51120 cggtcataaa cacccagctt ggtgttcttt gcaaagatat ccagcaaatg aggtggcttg 51180 tactgaccat agacaacctt gcgcaggtca tacgacttca ggcgggcagc aacatattga 51240 taattgggtt tatcaacaga aattaaggtg gccgcagctt ggataatgat atcctgaatg 51300 cgttcggttt tcatgttatc ggtgaattga atcttcgatg tggcttccac ctcagacacc 51360 gatactcctt caaggccgtc acatgctcgt tcaataacgg tatggagttt ttcaatgtca 51420 aaggggacag aagatccgtc ccgctttatg atgttaatca tagcgatcct cggtttatgt 51480 ttatgcaggc tgttattata caccgcctcc atggattgaa ggcggcgggg aagttcgtgt 51540 ggtatttaaa tgttgtacag gtcgttaatt tctaacatca ggcgggtgaa gttgccgcga 51600 ccattacgat cagacttatc gaattcgatg atgctgaatg gttgaaccca ctctggatat 51660 tcatctccga tttctacacc gtcaatttgc aaggaacctg tttccagctt attgttgaag 51720 tctttaaagg aatccacata cgtctgtaac gcactatcac gcaatcgctt gttagactgt 51780 ttgatatctc cattcacgaa gatgtacgaa gaatctgaag cacgagtcaa caagtttttc 51840 agctgctcca tatcgcattc ctgcgcttct tcgataatca ggaaacaatc atcgaaagtc 51900 atccccttta cagtttcaag gtcttgaatt tctatgatgc gtttctccca cagatagttg 51960 aagaaaccgt cggaacccgt atctgttttg agaacctttt taaatgtctg tatgagcggc 52020 atcaaataag gcatcagctt ttcatatgtg tcaccaggcc ggaaccctgc tgtggtgcca 52080 gttggaaggg gagaacgtgt gatgatgatc ttgttgattg ttttgtctat cagatgtttt 52140 gctgcagcag atgcaccaca ataggatttg cctgtacctg ccggaccgat tgcgatagtg 52200 aggtgttcgt ttaatgcgga ttgatatgcg aggttctgat tttctgagag gccattgaac 52260 ggagcaattt tgaaatcacc tttagaaaat ttcatccagt cttcttcttt ctggatggtg 52320 tctttcttac gagcagattt tgtctttgct ggcttcatgg atacaacttt agacgcagat 52380 tgcatgttga accttcctat atctacaggg gttgtcgaca cctttaatta agcgacacgc 52440 ccagcatacc tgtatatcag ataaagaaaa aggccgtttc cggccttgag aattagcaga 52500 aactcttgta tgctgccgcc agtttagtat catactggtt tttcgcatat gccggaccat 52560 tgtaccgacg agcaaactcg gcccaattct tgttcttcag ggctttccac atattggcat 52620 ctgccttgat gaacttgaca aatgccagaa ggtgagcgcg ttcaccagtc aggaaatcag 52680 tgaacatctc tttggcattt gaatagccac agatttggca gttgaacccc atgatctgga 52740 ataggccgta ggaagcactc tcgtaagcgc agtcctcgtc aagggcgatt gcaccctgaa 52800 ggcgttccaa ctccgcgtct ccgccgatat acccaccaga attggggtta accaatgttg 52860 ggtagagttg gtacagagca ttggctcttg cttgcccgaa tttggccgtc acctttttgt 52920 acatgatgtg gcgctcaaac agagttttga tcttgccagt tttggtaaaa cccgtgccac 52980 gggattctac ctgattcaca gctttcatac tggccagctc aacaccaagt tcacgtgctg 53040 cgtcaaccaa gtccgcttcg gtcagatgtt cctgatgagc gtctccagcg ttgcggatag 53100 catagaaggt ctttggccca gcaataccat caataaccaa tccagcacct gcctgaacgg 53160 atttgacagc attctctgtt gccttaccaa atatgccatc ggctgtaagg gagaaaccga 53220 ttttgttgag gctttgttga agcgctttaa cttcagaacc tcggttgcca agttttagaa 53280 tggccataag aaaatacctc cgcaatgtat gcgaaggtat ttaaagtgaa agtcgaactt 53340 gaggatctag tgtcgattac ctgactacga cgacaggcat gatttctttg aaggaagtcc 53400 taacttcgga atcataccca tatttttcaa atattttcaa catcgcttgt tccagttcct 53460 cttggaactg aggaaagtgc gcgttgggaa ttcggtcggc aacccataga gcgccaggag 53520 aggcttggat aattgctcta ctcatgtctc attctcctac caaaactttg aaagggggag 53580 gtttcctccc cccttgcggt taagccaatt tgttcaccag agtttctact gcgtcggcgc 53640 tcagtttacc cattttgaca tactgggatt tcgcttcacc gccagcggct ttcacgatgt 53700 cttcgtttgc gtagcctttc ttagggaaga ccatcacaga gaaggaaccg ttgttcagcg 53760 ggttcagctg gatgcggcct ttaccaacta cgatggtgcc gtaagtttcg gtattcgctt 53820 caacaacgtg gatgtcatgg cccaggtctt tcagcatgcc aactttgtca gcagtcttgg 53880 caactacggc tttgtctacg acaacctgct ctaccagggt gaagccgttg gtcgctttca 53940 ctttgccgtt cagcagattc atgaaggaag ttttgccacc agtgaagcca gctgcctgag 54000 cgatgcggaa catctcaact tttgcaactt cggtgttcag ctcaaaagag atggtgccgt 54060 tggtgatcag agttttggta gtagccatga tgtaattcct cataatgtag ttgggtcgtt 54120 tcacttttca ttcggcggtg tgttgtgtac cgccctatgt gaactataat agtgcatcat 54180 tattgaagag taaagtcttt ttcaataaat ttttaaatta tttttgaagt attttaaaag 54240 gcctcataga acgaggcctg aagggaaata atttgagtta aaaagtttta ggtcggcttc 54300 tttttcaaat actggcgagc caaatccatt tgttcttcag tgataggaca accgccgaag 54360 tccaccattc cgttcctcca accatggatg aaactcttag attctaagcc agataggaca 54420 tatccttcac gggcttgcat atacccgcga agaatctctt catcgtccat actattcagt 54480 tctttcaaat ccatcatatc ttcctcaagt cagaaaatcg taaggacgcc gacagtccct 54540 gatatacgtt cttggctatg atctgaagca gatcacgtat cgggatattt cccttgtcgg 54600 ggcgaaccat atcattgata tccttccacg gtatttccgg tggaaacaga acgactttga 54660 ctccgctgtc tatcatcttc tgtataccgt cacaaacttg tttgttcctg tattggttat 54720 cggggatata gatgtctccc ttagcactta ataagtcggc atcggcagtc gcaagacaat 54780 taggtagaaa caagctatca attggacctt ctactaccaa ctttgttttg ttccaaatga 54840 tgcgctcttc cccgtaaatc ttagtgtctt cgttcttagg cttgacagtg gcataccgta 54900 ataccccatc aggaaggtta tcgccgaatg cgcgcccctg aactatcttc atgcgcccgt 54960 cttgggtcca gaatgggatt accagccgct catcttcggg tatcttcttc tgcttctcaa 55020 catccgtttc gaaactcaga agatcttgac gaaaattcct gctgtaatat aacaaagata 55080 acgtgctctc aggcattccc ctgccttcaa cgtaacgacg ggcgatatga tcatgatcaa 55140 gaatatcaag gcgtatcata ttcccaaggt gctcttcatc ccgtttggcg acctgagaac 55200 cgatacgcgc tgtctgggtc aggcgctgta atggtttgag tttttgtaac gggcgggaac 55260 tggtatcccc catgatcctg aatttttcaa ggttgtattc attatacaga cgctcgtcaa 55320 atttcttcaa ccagaattca aacgcccaac cgctcatttc attacagttg tggcacttga 55380 aacgaaacac atcgtcatca cgatcataaa agaagtgacc acgacgcttg ttggcactct 55440 tcttagaatc cccacataat gggcaacgaa atttggcgac agcgccaaca cgttcccagc 55500 tgaatttatc aagtcggggg gcgagaaaat tgatgtattg ttcgtccaag aatttcatta 55560 gatatttggc ctctggaaca cttctgtcac attataatac accccgcgac tttgagctat 55620 gcaaagctgt cgccaagccc catacagaat attttgttcc gcaacctgat tgcgttcaaa 55680 gtgggcaaat tcttccagca tctgtttgta ccctaataga taaggaggga tatctgtagg 55740 acttcttttg cccaaagatt tagacaaata tgatgcataa tgttccggtg aagacaaaga 55800 ggaatattgc atattcggaa cgtgaacggg cttcaaagat tttctagggg tgaagtacaa 55860 caaaccccat ttgggaggga ggtcttcaat tttaataaca tctgctgggc aaacatagaa 55920 acgatatgct cccatgccta tggaaggatt catgcgatga ggtttctttt tgtctgtcag 55980 gaagtcggcg cgggagactt taacttccat taatatagaa caacccccag gtctgaaccc 56040 gatggcgtca ggggattcac gattatcgaa tgaatttggt tctacgaaca cagcaccaca 56100 attcatttgt ttgtgtagaa attttgcagc gatttgacaa ccttctgagt gagaaggtat 56160 aaagattttg cccattgtta tctgtatcct attgatgacg aatgggcaaa attataacct 56220 gacgatgatc ctattgagtt aggacaattg cttcagtttg taaatcgttt gatagcacag 56280 agtcttgatt tcgtcaagcg tattttgaag atgactatca cactgattgt agatcccatt 56340 gacgtcgatg accacgctgt tgatatacga tatcggttca ggattgtaca atttgatgtt 56400 ctcgaatcct ggaatgtata tacctcccgc accaatatac gcttccgtaa aggtgtccag 56460 caagtcctcc agttccccgt agaactcccc gagtgccttg tgcttggcat aggacgttgt 56520 aacgaagtgg agggcatgag agtgggctat agcaagcagt ccacggttga tgaatatact 56580 cgcgttaacc atgattgttt cctcagaaaa agaaatcccc ctgtatttag ggggattgtc 56640 atcaaggctt gatcaaagtc agcttgacgg tttcacccgt gctggtgttc gtcagggtca 56700 taatgttctg tgcgttcaca gacttcactt tcccctgatg tttatccccg ttgcgatcat 56760 agtaatcaat cagatcgcct ttgttagggc ggccaacgtc ggtgatgtca tacatgccct 56820 gctgtccaag acggcgatgg tcaacctttg cttccttcaa gaggaagtcc tggaatcctt 56880 tcatacaacc tccttagaca ggtttaacgc caatatattt ggcaatgtcc gcagctaggg 56940 ttttcccctt actgatgtca tgctgtttgc cagcgactgt gacaattaca tatggatcgt 57000 cttctccgcc gaagtcgatt gcgacaggtt ttccaatacc aggaataccg gaatattcaa 57060 actctgtacg accgctttta cgagatttgc caacgcccag cgctttaccg atcatcttat 57120 ccatgttcgc caattcttgg gcataggatt ctgtgacctg acctttgctg gcatctttcc 57180 caaagaagaa ctcaaaaccg tcatgaacgg caaccacatc tttaccgaca gaaactgcat 57240 gaacctggtc cggtgtgagt tttactttgg tggtgttacc gttagtcaat tccagattat 57300 agatgtcggc ctgattatct ggagtgatct gggtcacggt ggcaccagta caccattggg 57360 ttccgtcggc ctgtttggtg atggttacac ttttgccttg tatgccgcca tgagtttgcg 57420 gttgttgagc ttgttcttta aaatattcga taaacggttt catcgtggat ctcctaagga 57480 ttttgatgta tttagccccc gaaggggcta tgacttattt cagactaatc tgaagattac 57540 cacccagcga ttgttcatat tcactgtatg cactatcacc attactcata gcccattcgt 57600 cggattggcg agcgcgttca agagtcatga gatttggctc ggtaggatta tagcctttag 57660 atttcgcgtc gttgtatacc gtttgcaggt attggttggc acggttgatc tgatccttga 57720 attcacgata tgctccttcg gtcgtattgc gacggaaagt gatatcccag gcaacattca 57780 gaactgtacc attactggct gtgtatacct gccaatccag atctcgtcca ttaggagcgc 57840 tatcacgaat ggatccggca taggtggcca gatcgcctgc attcttacca ccagcgacct 57900 gatctttcgc ccgagccaaa gcatcaatga ctgccgtgcg gtttttggac tgtgccagat 57960 ctttgtcttg gaacataatt gcaccaaact tactgacggt gatatcattc aggaacagct 58020 tgttcgggtt atagtttgat gaactgagat ggctcaattg agccgcagcg tctttcaggc 58080 gttgtgaagt ctcattcaat gcatcttgca cagacttgac agataactga atgtcatatc 58140 cgctgctatt gactacattt cggccatttt ctgtcagcat ggtcgtgatg ttggccttat 58200 tacgatcgaa gtcgtaagtc acgttcgtaa cgaaccgtgc ggcttgcagc tggctacccg 58260 cagggaactg gaagtcccaa gccacagaga acccatgaac ggtttcacca aatatcttcg 58320 cattgcttgg ggctttcagg ttcgcagtga tgacagcgtt atcactggaa tttgtgttga 58380 tttcgccgaa gatagtcttc ccatcagaag actggaccat cagagtatct ttgctgcgcc 58440 agtcataacg aacaataaac gtcgttcgag ggaactcttt tatcagatcg agtttgactg 58500 ccttacccag agtaaatcga tttaacaatg catcggcgat cttcaaagta aacgaaatac 58560 aatcgacata agaataaccc tgagaacggg aaaccttttg aatcgggtat ggggcaccgt 58620 tgatcggaac aacacgacat tccacttcac cgttgaactg agaatcagca gcacgggata 58680 tcgcactgac gatttcaaaa gcagcgtttt tcacgtcgcc ttccagcatc agctgttcat 58740 tgccagataa atcagaaacc acttctacag aaagttttcc gttgacaatc ccccaaaaat 58800 agacttgaat atccaacccg ccagaagttc gatatttgcc agcaccaacc cgagccaatt 58860 tttcaccagc atacatgccg acttgctgag gagcatatgt atcaacgatg cccaagatgc 58920 gggcgatata accctggttg cgcagatcat ccatagaacc ggtttttgga agagttttca 58980 tgtcgacggg agcagtagcc cctattccaa attcaacata tgccacaatc ttgccgccgg 59040 acttcagttc ccatcccatt ccctgacggt cagaagctgc catgattttg cgatccactt 59100 caccgcgacc gacatattct ttgttgaata cggtcacctg agcgatagat tgggagcggg 59160 caatcttcgc cattgcgcca tctttgacca tgatggccag atcattggaa ctcagagtca 59220 catcgttcgc accgactacc ttcacaacag aactgaagat accgttggac ttcgccatga 59280 ttgaaatgtt ccagtcagga ttggtagaat ctgaattgct ggtgtcaaca tccacaacaa 59340 gtacaacctg cccgcctttc ttgaatgtgt actggtcata caaccctttc ttctgtttag 59400 acatgtctgc gccgattaag tcctggttgg tgaaaccgcg cttcatgctc caggatactt 59460 ctgtgccatc cgggtattta tcaaaattgt agccatagaa ggtggcaact tcacgggaac 59520 cgctcaccag tcggacgtag tttccgcgga tagggtcgcg accattcttc aattcaaggc 59580 tagtgtcgga agagttatac caatcacggt tgacttcaac ctctgaactg ttgtaagaag 59640 atgaagtccc cacatcagga gtatcgttct gaaccggaac gtcgccgacc ttgtccggat 59700 catcccatgt gacacctttc attttcggac catcgaatac ctgagcagga tccttgcctt 59760 tacgcacaac ccatacgaat gcacgatcag ggataggggt atacgtcagg tccatgacat 59820 tgagcttttg cttcaggccg gactgacgga taatcttcgg caggagggta acaccacgct 59880 ccaatgcttt cttggagaag ttaattgcaa agccgtcaat ggttttcccc aaaggcgtcg 59940 ccatgaattg ctttgttgct tcaatcatgg atgcgataac acgcatcgga ttcttgaaac 60000 gaccgatggc atcgggatat gtggaaccac gcttctgacc gataaagact tggcgaacat 60060 tcttgcctag accttgtggg gtatagaatt gaatacggaa ttctttttcg tcttcatcaa 60120 caaatgtgaa gaaaatgtcg ccagcgttct tcttgccgaa tgtcaattca tacggggatg 60180 agttaaacgc ttcgtctaat tgtttagact cttcaagaaa gttcaagaaa gatgggatgg 60240 ccattataat tctcctgatt ataaaatcgg tgcggtttcc cttaattagc gaaaccaaaa 60300 gggagccgaa gccccctggt gggtcacgcc catgtggatt tgcttacgga caggtaatga 60360 tttttggact cgaccagatt tttgccggac ttgacgatag cgtccatgga atagaaaccg 60420 atctggaatc cgtctttcag gaagattgtg tggtgcatgt ggttgacagg tttgccgttg 60480 acaggggaat tcttgaaatt ccaaccttca gccaagaatt ttgcgtggac tgctttcatc 60540 gtagcgtcgc gatcgccgtt tgtcgtgatg cccatttcaa cgttgtctgc taaaccacgg 60600 tcaacaatct gaccttcgag ggttacaacg ccgaagccaa gggattcaag gatagacatt 60660 tctggtttgg tgaaatctgt tttgatcgcg ttcatgatat agttccttcg tttcaagttg 60720 gtgtcgtact gcttatgttt agaattatac gtgggttatt gaagaagtaa aggggctttt 60780 gcccctttta ttgaataatt taaggtgttg gattgacaac gggaatatgg aacctgatcc 60840 cagagacaat gtccttcaat tgtggctgcc aacccgtgac caaacggggt agcgcattag 60900 aaccaggata gacaataatg atgtcgcttc cggttacatt atgttgaggg aattgtgaca 60960 tgtattgctc catcgtcacc cctgggtcta tcaataccgg accgacatcc gaagatgcat 61020 atgttgcccc caaaccgtcg actccccatg ctagtattcc ataatcagga atattggctt 61080 cagaagttat ggtgaatccg aagatacgat tcagcgcaga aaaatcatac acgccgtgag 61140 cactgtcata tgtcagataa ccctttgaca gcatatcagc gaatatcgcg tctgtgtcac 61200 cagttgccgg agtcggtatg gcaaacaata actcaccagc aggaggtgat ggatacgtgc 61260 cgagcgcata aaggcaccaa gcgtcaatgc atttcttgat gaatgcttca ggcgcgacat 61320 aatccgcaag gcgcattgta ccggaatatt ctgaagtaat gatcccttcc ttcgcgccct 61380 gaatagccag aaacaccatt atgtgttcat atccggtctg agatggagtg atattcatta 61440 tctggtcctc ttgagtttct caatcgtgcg cttattcatg gcgatcactc ctgggtcgac 61500 ctttgggttt attgccatgc ctttgaaaga cacacatcgt tgaagatatt tagccttctt 61560 cacgacgtcg gctgcataag aattggattt ctgattacga ttgaacccag cattgtaaga 61620 ggaaagggat ttgcggatgt tttggttatg atattctagc cagaaattca tttcatcaag 61680 ggcagcattg gcagcatatt cttgattgac cagtaatttg atcgcgacat tggcgtaaca 61740 cttctgcgtt ttgcatccct cccgtttccc gacggtttgg acgcgatttt gaaatgcccc 61800 catattagcc gatttgaggt tattctgcat ggatacgaca tcttctccgg cgcggctttc 61860 cctccatgat attgcggcga gagtgaaacc aaggtcttgt tgttttccca cgtgataggc 61920 tgtggccatg gttgaaagtt gttgatcaga aaactcataa tcacattggg tggtactttg 61980 ggaagcgtac acactcccgc tggcaatggt aaaggtcacg gacaaggcca tggccttcaa 62040 cgttgtcatc gtcatgatgg cgttccttat gtgtttgtcg acttgcagct cgctggagcc 62100 tcctgacagg gttaaaagat aaagggcacg tgatatttag tgcccttcac cttattcgta 62160 gatcagatgg tatgattcct cgatgcattc caaccaaccg tagacaaatt ccataggatc 62220 atcccaagct gtattggaag caatagtgaa atccccgtcc aagatttgca tatcagtata 62280 tttgttgaaa cctaacacgg catcaacgac tattaagcca ccttgctcta gataacgctt 62340 tggggtcaac gttacctgat aatgtttgtt tcgctgattc cataattcga cagcgatatc 62400 gcaagcaatc tgaatttcat ctcggctcat caaaagaact ccataagttc agatggtgat 62460 tacattggtt atacagactc tctaacaggt aggcaaatgc ttccgtggtg tgagtgttag 62520 ctaccatatt gacggcttca aatatgttta ttaccgcatg gctcagttca tgtaccaaca 62580 cacctgaatc tgaaatgaat actccgacca ccatctttcc acgactttca tcggaactaa 62640 ccataccgat agtatcttct aaatcatgta tgataccttc atcccttatt ttagataatt 62700 gttgtaaaaa gagtatgcga ctgttagtga accaaatgtc tgggaaatat ggatggcaat 62760 caagttttac aagaactttt cgcatatgtt tgtctcaaat attcagtaaa agatttaccc 62820 aacttacgga atagtttaat acgaccgatc actttgacat aaacatctcc atgacatggg 62880 cgcggcttac accagcatcc caaggtcttt ccatctaatt caaggagttc atcttcggtg 62940 atatcccctt caatcaggcg cacatacaag tcgtcttcga ataactcgat acaaacgccg 63000 cgcccatggt ctttgacttc gaagtcatta ccccatttgc caggccgccc aatgtagatg 63060 tcgtatggct ccttcttgaa gtggacgact ttcattccag ttcttcattg tcagagattc 63120 ttaccagaaa cgcctggtct ctgtttgctt caagatcaac gaatcttcga cttccgatag 63180 cttcaatttt ccaccaatcg aaagaacacc aattcttgat gatacatttg atagcttttt 63240 gctgcatact acaatgagcg cggcgatagc gttccttgta tttctttgtc caaccgtggt 63300 tgtccgcctt gtgatcataa ataaacatca ggcgaatagc tttgtacagg cgcttttcag 63360 cgcccttaga tttcttcgat accctgatca tgatatgcat gcgttaatcc ttcttaatca 63420 cttcggtcat gccattacgc agaccataac gaatgttgtg ttggaaatat tcttggaact 63480 cctgctcacg ctgactgatg acaaacagat tgttcccgcc aaatttatgt ttcaacatct 63540 cgacggattc ttgaacccct cgctcactca tgttttcgag tatctcatcc aacacgaaga 63600 ggttacattg tacagacgcc ttcaggttag cgacgtcccg cagggctaat gtcaccgcca 63660 gattgagtcg gctgcgttgt cccgtagaca gggagaatat gctttgccct ttacgaccag 63720 cagcgctcat agtgatttca aatgtatcat caaccgcaat atccaagaac atattgagtg 63780 cttcaagata ctcgtttatt ttactattga ggaaaggcaa atacaggctg ataattcgag 63840 ccttggtctg atcatctttt aggaagaaca gaagatggtt caggtcttgc aatttctcat 63900 ccaactctac gcgccgcgca ttcagatctt ccattaatgc cgtgatgcga gcgatctctc 63960 cttccagggc gtcagttggt gtcggcttaa ccgccaattt acgctctaaa tcggcaatgg 64020 atgcctccag aggggcacgg cgtgatttca ggctggtgag tttatcagcc gtgtcgttga 64080 tactcttaga gagctgctca cgcgcttgac ggattgacgt cgtgatatct tcgtaacggg 64140 tgtctacggc cttgaggacg tcgttaattt tggactgttg ttcccgctgt aaagatgttt 64200 tctcaacagc agcgacatca tagaatcctt ggatgtcgcg ttttaatgta gcgatcgctg 64260 attccgcttc tcggatttca ttgcgcaaag catccagttc tttgtcaata accgaaatct 64320 gagaagataa ttctgaatct ctgacattgt aattctcaat cagggaattc acttcttcta 64380 gggctgtatc aacctgaaga atcttgtcag tcagttcact gatttgcgga taatattgac 64440 tttcaatgcg tgatttggta tcgtccgaca ctaattgcgt acacgtaggg caagtgccca 64500 tatcgtggaa acgtttgatg gcagattcat gtccttccat ttctgttacg aatttgaaac 64560 ggaagttctc tccctgttga cgccgcgcca acgctttgtt cagttcgtcg agattagcat 64620 tcctctgacc gactagttcg tttttgcgtt ctgcgaccac cgccattctt tcgcggattt 64680 cttgtaacga cctttcgccg tcggatactt ctatgcgttc ataatcttca gccttggtat 64740 cggcttcatc ctgaactgct tggattttgg ccgcatactc ttcattgatg gcatcgatat 64800 cccctttcat ttcggcattc aggcgattac ggacttctga taattctgat tccaatttag 64860 agtcttgagc acgggactct gtcagttgtt cctgcactgc gccgatatct gaattcaaac 64920 tattcagacg ttccttctct tggacaagga tatcagcaga ttgttgctgg atcatcgcat 64980 tggaattatt gatctgttcc aactgcgctt gctggccttt taaatttaca tcatgaaagg 65040 cgtaatcatt ggtgaccgtc gtgagttcat tcgttactgt cttgatagat gcttttacat 65100 cttcattcat caaactgaag aaccccaaat cccagattgt ctctaccata gcgcgacggt 65160 cggcagtgta catttccgtg aatgggatga acttctcttt gcctagaacc agggagttct 65220 caaacatctt ctggtctacg ccaatcaggt tcacaatata tttgttcatg tcagctttgg 65280 ccgcatcatt cacgacctgc ttccactgac cgtctaccat ctgatagact tctacgaaat 65340 caggtttgat accacgacgg actttccatt cacttcctcg agtggagaac tcaacttcac 65400 ccacgcattc ctttttgttt tgagagttaa ccaatccggc tttcttttct ttcttgctat 65460 atgtgtcatt atacagaacg aagaacagca gccagacaag catggtggat ttaccagcgc 65520 cattgtcatc ggatgtaacc aaggttgccg aattgcgttg gtaatcaatt tccatgaatt 65580 cattaccgat ggaacggaag tttttagcgc gaccgcgatg gaaagtcagt ttgtgggtaa 65640 tttccccacg gatttcaaat ggtgcttcaa cagaaacagg agtgtccgct tctttcaaca 65700 gcgaaccaaa ttttgataat aggtctacat tgctcattat tatgcatcca atgtgttcag 65760 gcgttgttgg gcagcattat agaattgttc tgctaatttg caaacatttt cagggcgctg 65820 gatattattg gcggcgcgga tatctttctt caggacttcc acagcatcag tcgccaccat 65880 ctcttcagtg acttctacct tctcggaagc aacagtaatc gtccgatcga tgaagttgta 65940 atcgatgcat ttacagcgct tcaatgcgtc acagaacttt tcataatgct tggcattgtc 66000 acggttctgt acaatcacct taacgatttg cccttcaata cccaaaacat tgtttaacca 66060 atcgggatcg atccaattac cttcagtatc agaagacatt tgtgtgtagt cgtattccac 66120 gaaccggaac aacgtttgtt gttcgttgtt ggggataaac aattccccgc cattcatgtc 66180 gtctacatag aatcctcggt tcgtcccgtc tttgtggtct tcccaggtaa ggtgataagg 66240 agtcccaata tactgaatgt taccttccat cgaacgggta tggaaatgtc cggtatccac 66300 gcgctcgaat ttcgaaagga gcgccacgtc gatctgacct ttatcacata cagaggactg 66360 gtacattttg aaccctgcca actccagatg cgcaaaacag tacttggcgt ctgtatcttg 66420 tatcgcttta atggacgcat catagttctc tttgttaatc cacggcagta ggagggtctt 66480 gacaccttca atcattactt cagttggttc gctgtaataa tgataaacgt ctggtgccaa 66540 ttcattaaga taagaaggcc agttaatgcg attggactct tctaacgtga tatcatggtt 66600 gccaacgatg ccattccatt taatacctgc tttgcgcagc gctggcgtca attcatcttt 66660 caaccaatct ttatcgcgac catacatgaa tttgcgaaca tcaaacatat caccaaattg 66720 ccacacttct ttaatatcgg cgtcaaccaa ttctggaata aaataattga tgagataatt 66780 ctttatgaat tctcgaacgt aacgggaacc attacggctc ccgatatgta aatcgccaat 66840 tttagcaatc gccattattt tgtttctccc gttctaatgc tcgtttcttt gcttcttccc 66900 aatctggttc catagaacat atttcgtctt ccagattgaa ttgagtagag ccgaagtcat 66960 agtctgaatt atcttcggcg tcggcggtaa tggtattttc actctttgtg agacattgaa 67020 gtataccgcg aggaattttc ttattctttt cctcttcttt gatggcgatt tgcttttggc 67080 gttccttttc gcgctgggct tctttcttag tttcaaaatt tccgatacgc tcacggaagt 67140 ccattgttat accagtgctg tctacgaatg tctgttgctg gaagtctggg tcatctgata 67200 atgcagcgaa accacctgct tcttcaaatg aacgcaactt gatataattg tgttcttctt 67260 cactggtgag tttcttggcg aatgaacggt cggcgcacat cgttacccaa gagaagaaat 67320 tgatttttcc tttcttgccg atatgactga cgtcaaatgt atggaggtaa cgaaggatgt 67380 tgacaacggc ctcactgacc atgtcttcgc ggtatggata atcacgatag ttgtagcgca 67440 tactcatgtt cttaataatc atctgaacat tcatggccac ataattgggg attcttggta 67500 ggggtgttcc ttcggccaaa gcctttttgc gagccggaat ccaatctctc aatattccaa 67560 caacacggtc attatcttcg tctgtgaaat atttggtgac gttatcaccc ctgtctacaa 67620 aattcatacc catcgtgata atcctcaaat accaatgaat tcattgaaag aaccaacgac 67680 ttttttgacc gagaaacggt tattttcaag aaccattgaa ctatcttctt tggctctaac 67740 gctccactga tccgcaattt cgttgcccat cgttcctgca tgacctttca cccattttaa 67800 ttcaagttca caaattgaac aaactttgtc ataataatcg aacaactcga gcagaagttc 67860 tgtgttctta ggcggcattc cttcatattc ccatttacga cgccactcca aaacgctatt 67920 gataacatat tggctgtcgg atataatgcg ggctggggga atgcagcgtt caccgcaatt 67980 agagaatttc cataggatct tcatcgcgtt tataaccccg agtaactcag ctatattgtt 68040 cgttgacggc gggggtaaat acccataaaa cactttccat tgctctccag tgattggact 68100 gatggcaaat gcccaaccag cggctcgtgt cttctgaggg gatgatgccc cgtcagtgta 68160 tatttcaatc atgtataagt atcccaaact ggttttatcg atgaggaacg aatcatgtca 68220 gaacgcgcat atcgtttcag tctgaccgcc ccagaaattg agcgtttgct cttgtctata 68280 aatgattcca tacaaaagct ggacatcatt tatgactaca cggcgggtgg gactgaaggt 68340 caagtcgcag ctgcgtcagc tgtcaaaaac atgtggctaa aacttaatga gatggtcaca 68400 ggtgaaggtc ttaaagacgc aatcaatgca gctaacgaca gcaacgtatt caccgattat 68460 tataagtcta ttttagatcg cgaaacttgg aaatttattg gttctccggc agatttatta 68520 gcaagggacg atatagacac ttccaatttt gaaggcggtg aagtaatcct cctacaaaag 68580 aacgcttcgg gcaacccaga attccaatac tggaaaagaa ctcctgtggc aggaggtgat 68640 ccaatatttg gttgggaatc tgtttatgaa ggaaactcca acgactcttc tatcgatatt 68700 ccggttgttg ggaccagcat actgaagacc atcccaaaag cattgtttca tatggtcgaa 68760 ttccgagtac acgctcgaga gtctaccctc ggtcattggc aggacactga tggcaaaatc 68820 ggttatcgtg gtgaagatct gatttatagc ctgtataatc atgttcaaac caaaccgatc 68880 gcaaatatat ctttcagcca agatgtggac aatatgatta tcacgataac gacacttgaa 68940 ccaaatatca agtgccattt atcgtttatt gcgggttatt aaacctcaaa cactgcatcg 69000 gtgaaccagg ttgggaagaa ttctgggttg cgcatcataa gagattcaaa ggatgaatca 69060 atgatgtatg tcgcagccca gtcatcaaca cccctgaccg aacgcccgca catttgaaca 69120 atgcgcagta ctgcattgcg gaaatatgcc gacggatcca ctgaattgat atgtgctatc 69180 agtggatcac ccagataatc ataagggact ttgatcagta tttggaaacg gctgtaatcc 69240 cctttgaaat cataaccttc ttccatagcc ggactggcaa tgacacatgg ggactttgtt 69300 ctaaaagcat tttccataat atccatcaac gcctttcggg tacgcggaac atggataaaa 69360 ttctgatatt tgctgaattt ttgtattgcc aaggcgcgat cataactcac tgtatggata 69420 atgccggact gacctgggtg gaacgcgatt atttcatcaa tatattccgt caaccttttc 69480 atttcatagt cacccatatt gttagtcatc ttcactatgg gcatatagtt gacttttctg 69540 ttttcaatcg ggatagggtt gccgatctga atggaatgat aatccccctg tcgaataccc 69600 aatgaacgag catatgaatc tataccacag atcgttgctg acatatgaac gtgataatcg 69660 gcttttcgga ataacccgaa ttcacttaca tcagaaggca taacgggttt aaaccgaata 69720 aagtcatctc ccttttcctg tacgataaag gtgctggcct ttgtctgaga cataatacca 69780 caataatcac tcaagttatg caagacatct ataatgtctg cgagtttcat cacttgactt 69840 tcactcaggc ggtcatcttc aaccaattct tcaagaactt ccaacaaaga ctccacttta 69900 agatggaggt cttcaaacat cgaatgcatt tcaccagaca aagaatacaa cttgcccaag 69960 acatagtcct tggtgcgttc tacgatatcg gcaatgatag agactatctc cttcccttcg 70020 gggatagttc gcagtccgtc cacagccttt gtattgtatt ccattatcgt gtgctctagg 70080 agcgtagagg gcatcttatg acactcgtct aagatcagca tatcggaacg gttttcaggc 70140 ttcatacaga tggtggtgca catctcaatc atcatagctg cattagtgca acgcaatgac 70200 gaaatatcag tccataaatt gcgcgcctgt acataaggac aacggcgttt gctacaatgc 70260 ccgtcgcggc atgctatacg gcattgcaca gcgttgtaat acacatctgg gtgtacgtgg 70320 caacgatagt tcttcttgcc tttcaggatg tctatcgcca ccgccttttc agcagcatac 70380 tgatcttgta gacctttggt aggcgtactg atagacgtgc ggaattgtcc ataaggatcg 70440 gcctgtaaaa ccaaatgacg aatcacttta tgaattgttg tcccaatcaa agatttcccc 70500 acgccagttg gggcttcaat gattacgtgt ttgacctttt tgttgaccaa ggcatcaacg 70560 gcttcgacga tacattccat ctggccttgg ttcgccttgt catatggaaa ttcgtttttg 70620 gcaaggcttt gtatttcttc tataggaacc ttacggccta tggcgtcaat tgcctttcgg 70680 tgttgattaa atgctgtcac gttgttcctc ctttggattc tgttatagtt tacccgaatc 70740 ccaacaacga aaaagccgag gcattaacct cggcttctcc ttttagcctt gcaccgctgc 70800 actgcagaca tgcgctgggc cgacgcctgg tgtgattact ggccgttggc agcagctttc 70860 agaccttcac cgactttgaa tttaactaca tttttcgctt cgatctggat ctgttgtccg 70920 ttcagcgggt tgcggccagt gcgcgcttcc tgatgtttaa cttcaaacgc gccgaagcct 70980 acgaattgga cagattggcc agccgcgact gcagttttca cgccattgat aaaagatgca 71040 acgattttct cagcttcgcc tttggtcata ccctgggttt gagcgatgtg ggcgataaaa 71100 tcagtacggt tcattcggat tactccagtt ggttgtttac gatgtttcac tacaagagga 71160 ctacagctta cctaacaaat attattgaat aaagcgttta tttgccgacg tttagcattt 71220 tacttgagcc agaaccatca acaatcagag tacatttccc gctgttggcg caagattgca 71280 acaccatgtt atattcgtgt tgtaaatatt caggtgtcag agatgttgtc agtttctgat 71340 tcgccttggc ttcttggtcg cgaatttcaa cgttctttct tgctgtatcc aaacgtttgt 71400 cggccatgac attatcacgg atagattgct caatcgaagg atctgtcagc gcctttttga 71460 ccaacacgcg tgtgattgtg aacatgccag gcgcagctgt ttctaattgc tgctgggtgc 71520 gttccttgat catcttttct aactcagccc gttgggtgtg aattgtcata gaatccaaag 71580 aggaaacggc gtccatcgtt gaggatgctg cggcggtttt aaccaggttg aatcccaccg 71640 ctatcgtgcc gtcaccgagt tcagcgctct gacctgcaaa tttggtatgg aaccaaggaa 71700 ccttcgcgac gttcggtgtg taataaacgt ccacatccag atcttccaag gtcaggttgt 71760 ctttggcctt tggcgtcatt ttcgtcagac tcacgacggc ttctttagtc gtatagacat 71820 ctacacttga aacgaaactg gtgtagatac ctgcggttac agggttcatg tccacttcac 71880 cccattgggt tcgaacaccg acgtttcctt catcgataac accgccgcag cctgaaagaa 71940 ggcttgttgc taggaccata attgcgccaa ataccagttt cttgaacatc aatgtactcc 72000 ttcaaaaatg taaatataag cacccaacgt gagtgcagtt attgtaaccg aagaaatcag 72060 cagtaggaaa gttactctca cccgtttgcg ccaacgttta ctccggtaga ttttagtctc 72120 tttcaagtat ttgaaaaaga aaaataaaat gaatgttgtt attacgaata tgaacagata 72180 acggattaac ccgatcatat ttcccaccct gtactgcgca gatgatcaaa ataatcgttg 72240 agttcgtcaa tatcttcgat atcaacccaa cgatcatcca gtcccatatc atttagatct 72300 tcttcagtca gatcatgttg gtatatttga acgccggaag cattacaata atccggcttg 72360 atgttattgt tatactgaaa caggtcgtaa tcggccagag tattcttcag acgttgcgct 72420 tcttcaaatg ttggaacctc aacatgaaaa gcgaccccag gaacctgggg aatatgccaa 72480 acacgaaatt taagttcaaa tggtttattc gacatgttgt tcttcctgcg ccaatattac 72540 tttcatttgc tcacgagtaa tgatggtttc aacaaggttc tcgtcaatca tcatttcgtt 72600 taacagatca caacccagca catgtggtcg tgccatatac ggcatcgtgt tgagtttttc 72660 ttcaatgtca agaacgcgct tgacagtcag acccatcgaa gaaaaaggga caggataaaa 72720 gaatgaaatg atctgattat ccatcccgtt tgaaaatctt accaacaata catcacacca 72780 tacgccggac atattacacc tccagacggt tacaatgaga aagcgcgtta tcaatctgtt 72840 cccgagacag atattccaac gggttgcgag aatacgcatc taacagcagc agttggagca 72900 cagcgcgatt acgagtttca ctctccatca tgatgccgtt catatgtggt gaacgggctg 72960 tccatacaac atactgacct aaatcgtcgt tggcagtcag gctgatgcga aactgattgc 73020 acaatttgtc gattaacgca taatcatatg tgaacgtccc ttcagttttc cagcttgatt 73080 tcttcacctg aagagcttca ccacgaattc tgaattctaa cgtcactcca tgagtttcat 73140 tgtcgaaatg aacaactctc tgagtttcat ttttcagagt ccggttcata ttatatgcga 73200 agaaacgggc gtcgatctcc ctattgctca tggaattaaa atcgatcggc caaaatcgtg 73260 cacgcataat cgcgccttct ggcaatacaa ttagtccatt ttcacgggag acatagcaaa 73320 gacgtttaac tgtagggtca ggatgttcca cacaataaac ggaaattcca gtgggaagga 73380 tagcgtgggc gacaacacca gatctttcaa aatataaatt accctggtca gccccgatga 73440 taatacggct cttgttgttc ataatataga tctctcaaat aaaggcggtt taataataac 73500 cgcccttgta ttatagaatt attttatatc accgacatac atgttcaaac tttcatccca 73560 ttctaaacga acacgaatag tgccagaatc gtttgggaaa gacaatttgt cgcacatatg 73620 acgatttgca tatgttccgc tcttattaac aggataatct ttaccttcac cgattgcgaa 73680 tcgtttgaag ttccgactca ccatcatatt gatgttagtc cactgcaatt gttcccgtag 73740 ggttttgcac aatataatct tcccattaga ccggaaagac acgaataaat catttggtga 73800 agaaaatcgt ctttcttgcg gacataactg cctgattgaa ataaattcag attcttcttt 73860 attctcaacc ggagacttca cgggttcttc ttttcgtttt tctgcatatt gctcaacagc 73920 cttttggctg acaggcggca gatcaataga aggggagatg actgcgggct taacgactgg 73980 tgaagtacga gcagcaacaa gtttttcctg agcttccaga attctctctt ggcgagattt 74040 tggtcgagta tcaaccttgg agctgaaatc acaaaccgta acccagtcac cctgatcgtt 74100 gcgcttggca accagagtta atttgtaaat gatgccctgt agcttgcttt cacgcatagt 74160 gtctgcaaac cagaaagcgc acccttgctc aaatttttca gcgaagacca cgcgaccatc 74220 atcatggatc agaataacct ttgctttgct aggtgcgaac attttattct tttcaacgat 74280 cgcctcagcg atctttttgg taatgatcat cacgaaatac acctttcagt tcaatgggga 74340 ataaaatttt aacctgaaac tatctttgat ttccaacgaa attagttgca atttcacggc 74400 acatagtcag atctttaata gtctgtttgc tgttgtctgc agcagattcc atcatgggta 74460 aatcaagcgc attctctatc tggtccacac tatagagatc aaggcgtttc aattcacctt 74520 cataatcaga taaaaggatt gatgtgtcct tatcatctgg atgaaattgt tgatatgtag 74580 acaaccaagc agcacaaata ttcaacttac tggccggagc tgccaatact tgggaagaca 74640 tgaaagtgca caggaataac aataagattt tgattttcat ctttcgttct ccttcatcat 74700 attatcgcag tcaattcttg tttgcttgag ttcacgagca agcctgggat catcaagatt 74760 gacagacaaa ttagtggaaa gatctttcaa accattctga acacggtctt cataataatg 74820 atcattttcc accagccatg ctctcaggcc aagggcgcga gtccgccatt cctttttcaa 74880 acgtcgatct gattcttggt cggcactata ttcaaacacc ttgatgcatt ggttgccatc 74940 attgatgaga tccagctgac gtcggccaac ctgcacacct ttttgtaatg ctggagaagg 75000 aagagaacgg cactgtctta cggtcattcg tccttgtgtg tccatacgac cagtcataat 75060 aagatcgcca gcctccatgc ctcctcggtt aaattctttg tcgttcatat atcctttcag 75120 gttgaacgcg ccttgcttat atcgattaaa ctcaatacca gcatttacaa cggcatctgt 75180 gacattacct gtggcccaga gttcagcaaa gttctctatg gaaccggttt tgtctatagc 75240 gacggcttgg gagaacccag cacagtagga aagatcagac cacagttttt cacctgtgga 75300 gttcagcttg gcggtggcag gaagtgccag accagccagc acaaccccga tgattaaacg 75360 tttcatggtg attctcctta tttcattgga taaaatgata gggctgtcac catgttgagt 75420 aaagggtttc aataaactat cgtattcaga aacgggtatc gctgaccgtt ctgtatcgca 75480 caccctgaaa ctgtttagcg agtttaacaa attccatcgc tggcaaatca actttgtaga 75540 ccttcatgcg ctgtttgccg tccatgttca acgcagcgac aaatcggtga gaaccgtcaa 75600 caacgtaatt gtcagaagac acccaaactc gacccatggg cttcttattt ctgatctgct 75660 tcataatctt ccagaccttc attttattga tttcgttctg ggtaagacga agcattttga 75720 taggcacttg cgcagcatct atagacacgc cgttgtcttc aagatatttg tgaaaatctt 75780 cttgtttgtc ggcatcgatt tgcggcatag aagaacgaga aagcccgagg ttcccaacag 75840 gaatcctcag gccatttatg atattcatcc agtcaataaa ggatgtaagg aacatgacac 75900 acctcgggat atagggttat cccttagtta gttcattcgg acttaaacag caattcgcga 75960 acagaagtcc caacgatatt ctgggcgttc aacaaacgag ttaaatcatc catgtcatat 76020 gctgaattgg tgacatggcc caagataatc gccaacattc cctccagcgc tctccgattg 76080 ttattctctt caatgtcaaa cttaatttca acaaatcgag atagcattct ggattgagca 76140 tgagtttcgt tggttttgct ctgtataata tctttgattt ccgaacgagc aatacttctt 76200 tgatctgtca tgatatagtc tcttcaaaat tggaatgttt gtttcataac gttcaccatg 76260 taggatggat ctactggtgt tctgttatac gtgatcttgc ccatgccatt cagacgttcg 76320 acaatgcgct cggcattctc ttctactgcg gcctgggtcg gttggtaatc gttcaaatag 76380 atcgcgagtt cctgtcgatt gtcggacgtc acctgattgc ggagcgaagg atagttgaca 76440 acatacccac gagaaatcag ttcggcaaca agctgatcgt agcgctcgat cagataaatg 76500 agtttgtcgc ggaagaacag cacatgacct tcgttgagtt tgtactgctt tggagcgccc 76560 ttgagattac ggcgttttcc attcaccacg ttaaggacaa caggcgcaag ttctttatac 76620 tcggcaagga ggtgttggtc gcaaagagat tcaacgggaa taacattgat gcgagtcatg 76680 gtatagttcc tgcatttcaa atcgacgggg taatcatacc ccgccataat ttatagaatt 76740 aattgatatg cttcagaaga gcgaaaagaa tattcgcctt ggctttaacc ttaccgacga 76800 cacccgtttc ggcatcaacc tcttcagcaa cccatacttt tcctttcttg ctaatgataa 76860 catctcggcg cgaagcatag acttccttgg tcatgtacac acggcggaat cctttagcgc 76920 ggagcaagcc ccaattgcgg tctatttcta ctgccgtttc tactttcttg tttgacatgt 76980 tataatcaac ctattcaatt tctgaccaac cccacgttag ccagttattg aataatacgg 77040 caaatgttta ttcaagtaaa gcccttgaaa gtaaaaatcc ccaataatta ttggggattt 77100 catggattat tatttgcaga gaacaacgac gagttcagct aactctccga gggtaggatc 77160 atctccatgt ttacccaccc actcgtcact aatttccaca tcgtactctt cttcgatttc 77220 catgaccagc tcaatcatgt caagatcgtc accgccgaga tcattcttaa cccgtaacgg 77280 cgctaaagca tcgatattat catcaatgtt atcaaacttg tccttgtgat ccccgttgcg 77340 ccaggtttcc atgttcaggt tgtcacaagc gtactgagcc agaacacgca ttacttcaac 77400 ataagttggt ttgtttgaca taagcatatc tcaaaatgaa ggcgggtttc cccgccagtt 77460 gaatttagat tttgacttct ttttcagcca gttcggcagt gacggtgtat ttcaccccat 77520 caacttccac atccatagtg gattcttcca aatccaggtc ggtaaaccaa ccatgccctg 77580 caacaatccc ataaactacc ttggacagcg ttttgttcag ggcgcggact tcgttaatgg 77640 ccgcttttgc tgcgtctccg atccaacttt cgatcagctt tttctgagtc tcttccggta 77700 cgctggtgat catcggcgat ttaacaaacg cattgtattc agccagggca ttagcgatca 77760 gctgatcagc gacattgagt tttttaccgt ccgtctgttt tttgataaca gacgcgatgc 77820 tcggcagtga agatgcacct ttgattttca cattcaattc acgactcata tagacatcgg 77880 ttgattctac agaagaagtc ttcggtgaaa atccatagtc gcgaatgccg tttgctgaca 77940 ggaaatcagc cgcttctttg ccatattttg aagccagacc agtagcgttg cctttaccaa 78000 ccagttcatc acggtagaat ttcagaactt tttgcttcgc cttcaatgct tcacggcgca 78060 cattgtctgc aaagaattca gcagcactga tattctttgt catggcgcgg ttaaccattg 78120 ggatactttc cagatttaca atgaagactt ccggcccacc aaacacatga acacccatgg 78180 cagtcaaatc ctgtgccacc ttagcccgaa caatcggaga atctgcagtg ataggcattg 78240 ttttcaggtt gatgatacca tccttgacaa tggtgtaatt gcgataacgc caggttccca 78300 gctcttcagg aagttcatat ttcttctgta caaactcagg cacaacaacc gttccgtgtt 78360 gaactgtctg cacactgatg ttaggacgtt ctgaattata gaccaaattg ctgatcggga 78420 caatcccttt atcatctgct ggattgaatt cgggggtcca atcttcgtgc tcagccagtt 78480 tgagcgccag ggctttacgc tcttctttag aagtcgcatt cgcaatctct tcggccaact 78540 tgtcttcggt gtcatcaact ttctgtatag taccgcgccc aatgctctta taagagaata 78600 gcggatgctt ggtgacgata gagacatctg cttcagccag atacgtcaga acatcaacaa 78660 tggtggtggc gtcttcagcc ggaaccatat tataatcgat gccatcaact cctcgcagag 78720 attcgtctac gatagcctgg gtcagatcga ctttgatgtt ggaatagtcc tgcttggtga 78780 aacagttgct gtattgtttg atgaagcgga cgtcacccgt tttcttcagc gcagcccaaa 78840 ccaaatctgc gtccatggta tacacgccgt aaaatgccag cacgtatgcc gcttggatgt 78900 ctgccagatt atccagctgg tcgatcatgt tggggtttac aacccacagc tgagaaacgc 78960 tttcagggat gctgacgtgg ccaatagggt gctcttcatc aggatgcaca gctaaaacag 79020 tcgccacacc attttcaaca taaatggcat gggtataaac cagaggaaca tcgactacaa 79080 ctttcggtga agaagttttc agcacgtttt ccaattcggt ctgatattca ttctgtcctt 79140 cggcgaatac gtgggtcgca ccagaacgtt ctgccattag ccccagcagt tctcgattac 79200 aataccaacc atattcgatg aaggtaatgt tatcaaacgc tttgggcagt acttcagcgg 79260 catccaggat ttcattagaa cgccagcagt tgtcatatcc gtcggtcatg aatgccaggt 79320 tattaacata accaggttta ttcaggctaa tggcagtttc cgcagccaat ttcagcggct 79380 caacaaaacc agtacaacca gaaggcttca ggaaacggtc aattagatta ttgatctcac 79440 tgaggtcagt tgcactgtta atctgacgtc cggcaaatac cgttccgaaa tcaccgcgag 79500 atgaaaagta aaggatgctc acagtatctt ccggtttcac cagggaaggc aggttctcct 79560 tcagatgctt acggacttct ggaagtgaac gatacatgga accggagata tccacaacga 79620 ttacatggtt agacggcgcg acggtcgcaa ccgcattctt aaatgttaat gattcaatca 79680 tcgttattac cttctttagt ggtatggacg gcttcacctt ccggcttcgc cagcatgtgt 79740 tctatgaatt cgcgattagt ctcaatctgt tgaattaaaa cttcgctggg tttaaactgt 79800 gagtcaagag agtcaactcc tgaacgcaaa aatggtttag tcatatcaat tccctttcac 79860 ttccatgaca ccagaaatat tcttcagggc ttcacggact tccgacgcct tatctttctt 79920 tacaatcaca acaatgaaag aaaagttctt tttcttacgc caattcttga aatgagtgac 79980 caactggata tctttctctt cagcaccact ttctccagct acagggatat aaactgtgcc 80040 tgactcaatt acgacatcag catcgtctgg aatattttca tcgagttctt cacggtattc 80100 tccattaact ttgacgcaat ggtcatcgtg ccaagcaccc ttttcccaat attcgtcatc 80160 gttatagtag gcgttgaatt caacaccttt catttttacg gacatgattt cctcgcttta 80220 caattagacc attatacctt ggcttgttaa ttgaaacgcc cagcaatttg ccagacgtta 80280 ttgattttga aagacttttg aaaattacaa gtaggacacc acgatggctc tatacagcgc 80340 ccccacggaa tcaccaggtt gggctttcgg atctaacaag aatttcttaa cacgatcaca 80400 agctgcttgg cgtttgtctt ctgacaggtc acaccacgga taatcccctg aagcagcatt 80460 acacgttttc gccaaacgca agacaagttc agaatttagt tcttcagaag tcatgaatga 80520 gcgaagatac gcttccacca aagatcttgc ttcaccatta cgccgttcgt tataacgttc 80580 attatcggtg cgaacaaatt caactcgaaa tccccgactt ggatccttgg gatgacgaaa 80640 cacgacggat tgtcctttac ccttaaggaa ttcagaacca cccatctcat gtatcgcttc 80700 cctttctgac acatattcat caatgttgat cttagcatct ttgacggaca catcgataat 80760 ctgcctttct accatcgcgc gatatgcttc cagttcccac agctgggaga aggtcttttc 80820 ataggccagt ttcttaccca actcttcatc aaagttggct gggtcgatag aagttgaact 80880 attcttcccc cagacgacga agccattgtc catcttgaag tggcatgtaa tgacacgatg 80940 gccaccgact tcacggtctt cataaatcac ttcagcaata tgtgacttca gaagttctgg 81000 tgtgagttta atcccttcac gattacccat tatccacccc cactttcacc aaacgatcca 81060 gtaattggta aatcttgcgg ggacaacgcc ttaaatcttc atccgacaga tatagcactt 81120 cggtctgaat atctttaaaa gttgaaaggt tattcaactc agattcgacg acggttttca 81180 attgcgtata cgcttcatcg caataatttc ggcggttgca gtcggtcatt acctgagata 81240 acttttcaaa agattcttgt atttcctttg acatcgtttg acacctctag ttgattacac 81300 acagcgacta ctttacggca catatcgata tcgaacaagc cgatatggca atcgcgcttc 81360 ttgatcccca gattatgagc cagccagctg taagcatcac tcctgctcct ctgcccactt 81420 ttccagatag ggtcaaacga cctatgagct tcctgcttag cagcacggag agcggcattc 81480 gccatccttc ccagaggttg tctaccatcc ccatgggtat ggcaacccac acgagcgtcg 81540 catggcgagc atacccagaa cttcagtttg tgtagatctg ggcgatgagg gtagagtaca 81600 tcaccactga cgtatttggc aggaagaccg caataatcac aaataacttg tttcatattc 81660 tttacctaaa agaaaccccg cacacggcgg ggttgctcag gccggagccg acagattatt 81720 tcaacagcgc ttccagttct tcaagagatt taccttcaag ctcctgctgt ttcttacgct 81780 ggatcagttc cagaataacc tggttgttcg ctttacgttc ggcggcggtt gcgctttcgt 81840 cacgttcttt cagtttaaca ccgatgatcg ctttcacgat atcgaaacgc agttgtaact 81900 gagagtcgac tgcgcttttc acgccgatga aatcttcttc atcgctggcg gcttccttca 81960 cctgacggct gaggtctttc gccagttcgt ttagggcatt caggttcaga tcccaaacct 82020 gctcaacaga cagcagacct ttgttagagt tgaaacgcag ttttaaacgg gttgcttgat 82080 caaacatttc attgttcctt attacgaatt tgtggtcaaa atcaattaga aaatgacttt 82140 tacagtacgg ttaaacgcgc cggacacttt gacgaacacg tgattgcgtt gcgtcgttga 82200 gaatcccaga ccggacagtt ggttttcatt cggctggact ttcattttac tacccaacat 82260 ttcaaaaacc ttacgatgtt tatccagttc tggcttcaga tattcgttgt agaaaccacg 82320 agtaccttca ggattagcac agccttcaag aatgaagaac acgtgcttgt taccagtttg 82380 ctccccatcc caatggtttg gtgaattcag gaccagctgt actttctgga aggtcgcagt 82440 cttgataccc caaacttctt tagacttatc aacattagcc agttcggact taatgccaac 82500 aacttgtttg tctttaacag tcaggatgac tgcagtgata cgcccctgat ctttcaggcc 82560 aggatggctg aaacgatgcg ttgcgccttt gtattctact tcgacttcaa acccttcgtc 82620 gattttttca cgttgattgt agttgtggat ttcgaaacgg tattcaccat cgcgcagctt 82680 gctttcatct gtaaagatga tattttccac cggggcgcgg tttggatcaa taccatccat 82740 accgttcata tcgatatcca gatgggcacc tgtcatagag cggcgatcac ggaagtaaac 82800 gtgctccatg ttgttgaaca tatgcagatc gaggtcgtcg ttgttgtgcc acgccaagga 82860 aacgcgcaga tacccgtcaa ctttaccacc agcagccttt acacgttctt taatggaatc 82920 ggtcacttca ccgttgtaag accaggagaa accgttgttc cacttgaaca ggttaggcgc 82980 atctgggttc gccggagcaa ccagggacat caggttgcta gtatgagaat tctctacaag 83040 cacttccatt gaatgcgctt ttggcagaac attgctcagg aaatcatcaa cgctgatctc 83100 ttcaactttt tccagggact tggtcggagt tttcacttcg gcggccagct gtgcaaacgg 83160 atccatcgct ttctgagcag ccagatctgc gaacagaacg ttgttgattg tcagatcatc 83220 ataaaccgca taacgacgcg ccagtgagtc ttccaaaccc agagcaataa cttctttctg 83280 agcgttttcg atcatggatt ttgaaaccag cgctgtcgga cgtttgtagt tcgccggagc 83340 aactttggat tcaaacgatt taacagcctt ttccagttcc acgccttcgc tgatatctgt 83400 cagcagagtg ccgataactg tgttgcggat gccgtgtgga acatgattgt ttgaacggta 83460 tccagtatgc catgcccaaa gagaacgggc tgattcgggg acttgttcat atgacttttt 83520 ggtttcaaca aatcccttca ctgctgcttt gtgttctgcg ccgcgataca gagaattctg 83580 gtcaatcagt tccagaacga tttcagctga ttccagagta atttcacgca gaccgcgttc 83640 aaacaattca atagcctggc ggatttcacc ttttttcgaa gcgattgcgt ccggacgcag 83700 aacatagcta ccaagtaatt gggtatggaa atgattgtaa gtacggattt tgccatcttc 83760 accagattcg tgattgtgag acaggccgac tttggcagaa tcgttaaaat aaacatcgac 83820 gattgcgtgt tgtttgacat acgcggaaag agccgcagcc accacgtcat attcattacc 83880 cagatcaatg ttgtcccaga tagaaattac gttcagttct gaatcgatgg tgacaacacc 83940 gccgatgtta cggatgaatt gtttacagca ggtgcaatcg tgttcagtac gttcgcggta 84000 cagcgggtta gtaccagcag ggaaagatgc cagatacaga tcccaaagag catctttatc 84060 gatattggtc atgaacagac cagttgcgga catcgccagc acgttgttat taactgccgt 84120 tgcgaagggt ttgaattctg ccatggtata gtcttcctgt ttcagttcaa agtgagcgcc 84180 cttatcgggg cgcgtcgtta aagtgaggtc aatatacgct gaaaagattt attgaaaagt 84240 ttaaacggga atcatgttta ctcgaatact tctgaaccgt ttcccgtcat aactggtgta 84300 accaacaacc gtaactgatc ttgttccctt tggataaccc tttggagtac tcacaacgcg 84360 cacagggcgc ttgctttctt tatcgtattt cgaaatcaat ttcaaaagat gtttatcgat 84420 ctggcttaaa ctatcaccat acacggtata ttgatattgc tcgcaattac ccaacaaaat 84480 gataaattta taaattttgt cgaccaaaga tcgacatttt ggatcatcat aatgatgccg 84540 acagacttga cattcatatt tcccagtatt catgttgaac aattttgtcg cccgacttga 84600 acacgctggg catactttcc atgaacgatg atgttttacg ggtttcattt tttcatcttc 84660 tctaacagat taatagaacg aacgggagtc ttctgtaatg gctgattaac ttcaccacca 84720 ttatacccca cctttcctcg aggtttctcc ccgcgcatca ccgcctcaac gcagcgggta 84780 tatttctgaa gttcacagaa catgttctcc aactgcataa cattcatgca acggtcttcc 84840 ggttcttcta ccgaccaaaa ttcattacgt ttatacccgt actgagcgaa caattgatct 84900 tgatgatcac gaacccagaa tatgcattct tcatgcgtca tgccgtcctt gtccaaaaat 84960 aacagatcga taccagcacg gcaacctgga ccagcgatag tgaagtggtt ttcactgaat 85020 ggatattcat cgatgtatgt aaaatcaacc caaatctggt atgccaagaa tggtccaagc 85080 ccctcaatgt cgtcatacat cgcctggtaa acagagtcgg gacggctaaa ttccctgagg 85140 cgatcaaagt aatgagggtg tttgttaacg aatgccttca aagagcggat gactcgcatc 85200 ggcatgtatg gttcccagcc ttctattttg tattcaccag gattatcttc ggccagcttc 85260 ttggcaacct tgtaatccat ttcatctata acaccgccaa cccgatggac ttttaccttc 85320 atgccgccaa agcgttgctc cttgtggttg acaactagtt cagggaaagc caggcattgt 85380 ttcagaccgc ctgtattaaa cgcattggtg aaaactttgc cacctttaga ttcgaattcc 85440 tgaagaacat ctcgacacca ttcaagattt atgtttccga attcttcgat cgtccatgga 85500 ccacccaaag cctgtatagg ttcccacatg ttgtacatgc ggaacaatac acagttgaac 85560 attttgtcag atagcgtgag atcctgatcg aggatgatat tattgatcaa atttcgagac 85620 tgcctatcgt gctctctccg cacgttacaa aacttgactt ggcgtaatac cggattatcc 85680 gtccatggcg ctggaaggca ttgcacgtcc ttcttgacat gtatcgcata acgatccctc 85740 atccattcat atgccagctg gcggtggaat gaacttaaca taggatgggc tgatttgatt 85800 ttggtttcac ggacaccgca atatgggatg tcatgtggtt tatctttcat ggtatcctct 85860 ctagaataca aaaacagagg ccattatagc ctctgttgtt tagtgaataa cggattatat 85920 taatcgaagc gagagaggtg tgtcacagtg ttttgaacag gtgcgcacgc gtatacacga 85980 acattagcac cccacacccc acacagctta ggcatattgg tatcgttaat gatatacgct 86040 ggcacataac tttcaatttg gccgttaaca tctacgggtc gagaagattt ttcaactgcc 86100 atagaaagaa ttacttccaa cgtttttgga gataccaacg ccacgccgtt catatcatca 86160 acaaatacct gaccttcttc aattgccatg ctggcaacga tgtcattgat ctgacgggaa 86220 ggggtattcg tcagcatatc agagaaatca ggctctttga acacagccat gtttttcagg 86280 aattttcctt tcggatattc tttgccattc cacatcacag tctcattcac tttgatgcat 86340 gcctgaggga attcaccttc aacgcgtaac tggccatctg ggaaaccgcg tgaataataa 86400 tattccagtg ccggaccgac ttcatcttct gagcgaataa atttgctcat gttagaggca 86460 aacacacgtt gtaaacattc atcaccatta aaaccagcga tatgggccac gccgtcatta 86520 acagttgtga tatcaccctg agcgtccatg atggctttca ggattttatc catatcaaca 86580 tcatcggtgt cttcttttgg agttgccacc agctcaagtt tgatgtcatg atcgaaataa 86640 gccgcttcca gtaattcgcg ggtctcttcc agaaccagtt tggcttgatt gcgaatttta 86700 ccgaagtcag gggctgtaat atctccagcc gcattaccaa aagccaaatt caatctcacg 86760 tttttattaa atgtagttgt cataatatag cgactccagt tattcgcttt ttgcccgact 86820 tgggcgaatg gtgtattttg gaaccaattt ccactcagaa acttggtcat gttttacaac 86880 tttgatccga gacatgtcag ccacttcggt tatttgttcc ggatgcaaga tcttaaccat 86940 attccattgc tccagaagcc gtataatccg attcatacgc aggacatctt cacgcgtaaa 87000 gccgttgtag tgcccatcta gcatgaacaa atgcttgaaa tgcacgatgt gatatctgcc 87060 aaatttatgc agaatatggc acgtttgata caaggtgtta ggctcttgac gagtgttaac 87120 ccctatccga ctcagcgttt ccttgatacc caggaaaatc cctggtttgt cttggttcaa 87180 ttgaacttca accatacagt caacaatgct ggcctcatcg ttgacagctg aaagttttaa 87240 gatgtccagc gtattacgcg ccatgactca taccccttta acaattattt gaattactta 87300 gccttgcgcg gtttggcttt ttcgttgctg ttggaacgtt cgaccttcgc cttgatttca 87360 gccaggactt ctttcggcag gaatcgaaca tattctgaag ccttttcagg actgatgtaa 87420 taatactcag aaatcaattt cacatcagga tccatagctc ccttcttaga ccacttgtca 87480 tagcgacgtt ttgccggaat gctatgaaac gccaggttcc attgcatcca aggagtaatg 87540 gcatggaagc ggttcatttg ttcagcaacc acaagcgtgt ctttactctg agcaaggccg 87600 cgccgagtca tgaaaggatc aaatgccttt ctgatttcgg ggtcttcggt catcaacaga 87660 ttctctttgg tgctattcaa cgcaccgagg taatcgaaca gtgacggagc ggccataata 87720 ttacttccat ttgatgttga gcatgacgtt agtcaagaag taaacgccgt gtaaccagac 87780 gtcgccgacg gaacgatgtt caatctgaga ctgaccacag acacatacca gatcagggat 87840 tgactctttt tgaatcaaag gagtcttttc cttgttctgg ggaacgcaga aatggaagaa 87900 acgggaataa aaatcttcag tgatgtagtt ttggttgtcg gtcacccact gcttcatccc 87960 agcccaatca ttggttttta ggaaatccac caacgcttgg aattcccctg ctttaacctg 88020 tgccagagcg cgttcatcga ttttaccaaa cgtggtggca ttatcctgaa gagttcccat 88080 aattttgcga ttatctggga aatatgattt cacaatggaa gcaattacac cagcttcata 88140 cggaatgcct tcctctgtca ggatagttgc gcaacgacgc atgaattgaa gtttaacttc 88200 atctgcttcc ttttcagacc agataaaatc aatttcgcga cagcgggaac gcagaggttc 88260 gttaacgcgc tgtttcgcat tagtcgtcag gatgaaggag cagtttttgg agactttctc 88320 tacgatgcct ttcagggatt cctgtgccgc catagaaagt cgctcaactt catcaaggat 88380 aacgacttta cggccaccga aaacactgac gccagttgcg tattgaataa cacggtcacg 88440 gatgacatca atgctgttat ccagtgacgc attgatcatc aacggtttga tacaaccgat 88500 ttcgttgcaa acagccagag cagaagtagt cttgcccgta ccaggctgag gggaatagaa 88560 cagcattgag gggatgtttc cattgcctga tgtaacatag ccatggattt ttgcacggac 88620 gtctgaaggg aggacgatct catccagatt gtcagggcga tatttgtttt cccacgcgta 88680 ttgatctgtg acgatagtga tgttagacat tgcagcctct ttagataaaa cgtttcaaag 88740 ggcggggaaa ccccgccacc gataataaag cgccgaatcg ttattgatta atccagctgc 88800 atgccgacgt aatagttgat ggtgccgtct gcggattgga agttaaccag ttgcatttcg 88860 gcacaggcgc ggatcacgta gttgccttcg atcattttca ggttgaccac atcaacaggc 88920 atagcaaaat cacccagagt tgtttcaccc aactcaacag tgtaatcgtt ggaattgtcg 88980 atagtagtgg tcgtgcccac cagacgagtt ttaccgccgc tggccaccag gcgtacagtt 89040 ttgtggccca gagtagaaca ggcgcgagtc agctctttca ttttttcagg agtgactgtt 89100 gcttcaaatt ctacagacgg aagatcgatg ctgtctgccg gaacgacagt cagttcttta 89160 gcggaacgcc agaattgcag ttgggagttt tcacctttca gcaaaatgtg gtcttctgac 89220 atttcaattt taccgccttt aaaactcggc agacgctgga ttgccagcaa tttggtcaga 89280 tccagaatcg ggaattcgaa cgggaagtct tcgtcgatgt cggcaatagc gataactgta 89340 ctggaatcgt taacagtgcg caacttttta ccaggtgcca aaacaataga ggggcagatg 89400 gtttcaaagt tagccagcag ttgtaaagtg cgttcggaga gagtgatctc ttgcattagt 89460 tgtatcctca aaatatagtg gggttcaagt catatttgac gcaaattagt atcgcgtgtt 89520 tgtagttata gaacaagtaa taaattgccc tacgcgcgat aaataaatgc ctgacggcat 89580 ttataatatt ctgttttaat aaaacctttc tttaacagtc tactcgcttc gctcgtgata 89640 atactcgttg ctcgcaaagc tcacaactcg tatattacgc acggattgtt caacaagaaa 89700 gcgattttta ttcaacaatt aaaatatttt atttggtcta aacagagcat gacattatta 89760 tgtagccaag tttgctaaca cgcgagaaat acatatgaag caatttgttg gtttatacgc 89820 agtaggggaa gaccaagaag caattctttc catatcagaa caacgttcgt cattaaaagg 89880 cgtttattta caaagccttt tctgtacatc ggggtttgtt gtgacaccga tgatggtgat 89940 accattactc ccaaataaca aaggtctgta tgttggcatt attcaacaag gccaggcgcg 90000 ggaagtgaaa gttgttccat tgctggcatc taatgaagaa ttgttttctc agattcttga 90060 gccgaaagtg ctacaacaat gtattggcac gatcgactgt ttatttggtt ccaacaaaga 90120 aggcgaggca acccccgcct atgtgaatca agatatttga aatggttaga gcgccacttt 90180 tttcatttta acagggtggc gctccataag ataaaattta tatctctcat gagaatgcct 90240 gagagcatgg ttgtaggaac cgttgtagcg caggttgtct accaggtccc aaattcgcgc 90300 aacatcctta gaggaatgct gacgcatcaa acgccccaat gtctgtataa cacggatata 90360 agatttgctg ggatgggcca atatcagatg atggagtttt ttgatagata cgccctgttg 90420 catagtacca tatgatgcta acagtgttat atcttcccct tcttccatag cagcctgaat 90480 ctgtttacga acttctgtct tgacttcccc attgatgacg aatacgtttt tcttgactgc 90540 cgatagcatt tcataaacca acatcatgtg tgcatcgata cgttcgaaca tgaccgccac 90600 gttccctttc aaagacagag ccattcgggc tatcaattca ttgcggcgtt cgttagcaat 90660 gagaaattct atttcctttt gatactcagc accgtgcatt tcaatacagt ctgccatagg 90720 atgtatgact tcaatcatat taacattgat gtctgccgca tatcctagat cgattaaatc 90780 gcgcgctgta ataattttat gatatgcacc aaagtgagca acgacttgta accctgcgac 90840 ctttgtattc gccagggttc cggttactcc caaacgttga tcagcgttaa tacagttgtt 90900 caagatataa gacaatttat ctgattttga tgtatgtact tcgtcgacga cgatatctcc 90960 aaattgatgg aaccactctt tgggttggtt ctggatacct tgccaagttg aaataactat 91020 gggtttgaaa atctctttcg ttgccccttc gtatattgtc tggacgttca tcaatggctt 91080 ccattctgtc ccgtggctat attcttcgaa gttgtcatac aactgagtca ccaaatgaat 91140 ggatggtaca acgattaacg tcctcagatt actttcgagg gcatctctgc gttgcctgta 91200 gtaacgagcc atgatgtaca aaataaagga tttgccagca ctcgtagcag cttcgaggac 91260 acatctgctt tggcgtattg ctgtggcaac ggaatcaaat tgataatcgc ggacaatcgc 91320 tttttgatat tgtttgtttt cgtctcggta caccgcattc aatgtatcga tgaacgcatg 91380 aatttcttca tccggaatat cttgaatata ttttaaggcc ggatctaatt tgatggtgta 91440 accgttcatc ttacagaatt tgaacacctc aaataacagg ccgatgtcga taagcccaga 91500 actctttgtg aacaaccgca ctacgccgtc ccatttactg aacggattcg gttggaaatt 91560 aggatcttca aatttgaagt aatcgttgag ttcttcacgg atataatcct cggcaaggat 91620 ccgcattcta acttcgttca ctttgactat ttggatctca gacatcacta atttccccca 91680 atattatgga gtatttagcg atccgcccag attcctttct gttctttgtc cattttgtga 91740 tacagacgga cacggtcaaa cattttagaa ataacgtctt tgcgatcgaa ttcgattatg 91800 gtgggaacaa gggcattttc gttggatata atattgatta aacgctctat cttgacatta 91860 aacatttgtt gaaacatgac tgagtataga cacaattgaa tactataatc ttctatcatg 91920 cttcgagttt ttagggtgtt ggatgttttg aaatcgatta tgcttggaat tccttcgtaa 91980 accccgatga ggtcaacacg accagcaaga cccaggactt cgctatataa tggaatctct 92040 tgtgcatata tcttgctcat tttgttaagg taggggaaaa cctgtttgaa cataaacacg 92100 tattcccctg cagcttccag aacttctttc attggtctgt ttttgagata caactcacaa 92160 gccaaatgaa gtttttcccc acggtctgcg caacgatgtg tttctatatc agcagcttca 92220 tgccccaact tgtcccgcca ggcttctaac catgtgtggt caccagtacg ccctaacatg 92280 gtcgtcactg aagttaattt gactccagtg ggggaaacat agtgacgacc attttcggta 92340 gttacgcaag tcagttcctt aaacggcaag gaatattgct gaaatgtgtg atgacgattt 92400 tcaaagtcat taagtttgcg caaagcctgt agagaaacca ttacatccca tccaaatatt 92460 ttcgccaatc aatagcattc ttcacttcat atccgagttt gttcaaacga tctaagcaac 92520 tttcgatgaa cttgactttg gctttctgct cttgaagcat gctagacaat tcgatataat 92580 catcatctgc ttttacccat acatctatat cagatttcag gggtcgaact tttaatgggc 92640 gttcaacata aacgttgggc ggcaattccc ctgcataaaa tcggcgtaaa tagagatcta 92700 tttggcggaa tttgccagtt agatactcca gatatcttcc ttcacgaata taatggcgtt 92760 gcacagtcat ccacgaacga ccaattttca atgacatttg gtccaagttc atgtcttcag 92820 gatttaccga aataagaggt tccaattctg ccattatatc ttcggttttc atcgtttcaa 92880 gttttgtttc gctcatgatt tattccctgc tgtttcaact ctctgtatta taacttattg 92940 tttatcaatt tcgcgggtgg cgcgagtcgg agtcagtttc aaatatttga acgtaacagt 93000 cgtgaccagt tggggaaccg cagcatccac atccaccaat acgttatcca aagctgtggg 93060 acgggcttct tccaacaaca attgtagacc aataggtcga ttcatgttat caagaaggtc 93120 gatggtgatg tcgcggctaa cagctaaatc agatccagca ttagacgcaa tccaattgta 93180 aatctgttcc cagttgtacc aactctcatc gataacgaac gtaaatacga tggggtcata 93240 cgtgagacgt tctgaaggta tggagttgag cacatcgcca ggggatggac cctcgatacc 93300 ttcagaatac actccaggaa tactgaagtc atgtattgaa cgagtaagca atatcaggtc 93360 tccgatagtt aagcgccatt tatcggaagc cgcgaaatta ggattttcgt ttttgaattg 93420 tacacctgtc atgttagcac ctttgctgtg gagaacgttt tagtgttcct gatacgcgga 93480 ttcagaaaat ggatcatgac gatgataatg gtgcttgcac tcacaagttg ccgtatcttt 93540 gtcacgtccg tcatttctgt aaccgacctc tgggatcctg aaatcagaac catacctgtt 93600 aacatctcag ccgacattga taaatgcaat aaaaatattc tgaatcaagt agtatctgat 93660 tttcagaact tccagactct tcaagctgtt ggttgttttg atgataacaa ccagtcactg 93720 agaccatact ggaaaaccac gattccccta ttgaggaaag gtgacgaagg aaagatccca 93780 tatctatccg caagtattta ttactctcag aataatagca tcatagcgac tttcaaccct 93840 tctttctttg acaaactcag aaggaatact caagcaaggg acgtagaaat caccagagac 93900 gttgcaatat catttcagat agttaataac accaaatctc cgatccgaat tgccactcag 93960 ggtgttttcg ttaatggatc tgctgtaggt aatgaaatga acatctatga aataagacca 94020 ggcggtaaag tatggattcg aatgagtgat gttggggtga actccctggt gatggaaggt 94080 atcgaaccag tgggagttct ccccgctaga cattaattat ttcagggact cttttaattc 94140 tggagtccct attttatcaa taacgcctcc agcacagaga tctttagccc attctccaag 94200 aacattcgca aaagagaagt ttagacattc tttgatcata ctttcaatat gagcaagttc 94260 tgcagctatc ccatcggtga tatcgtttat aactccattg acggcggtta ttgcctcatt 94320 gatatgtcct gttacttcag cagccaattg ctgtagtttt gccatccctt ctgaggcacc 94380 ttccataatc atgtcataca attccgatat cttgtttgtt acggtctgta gagcaccttc 94440 catagcattc agccattggc gtcctaaatc ctgaacaaca ccaaaagcct tgttgatcaa 94500 atcacaattg tttggctctc gtgatatacc cttcagacct gatttgtatg acacggaagt 94560 accgatgcga gaatacgcgt cattgatact ttggtcgcca tatgtgttca gtgtcgttat 94620 ccccgtgttg gcggtgctat acatggtggt ggctgctgtg agtttttctg gtgttagtcc 94680 accagcaacc atagccgcct gcatctccgg agtcgcgttg gcagttatca atggtatatt 94740 ggtactacca ctggtgatta aatcctgtga gggaccggag agggacggaa gcggattgct 94800 aaatgcgtta ccagaggaaa ggacatcgta gatttgtgcg ttcataaaat acccccaatt 94860 ttgggggtat ttataatcat ggaagatgat agataaaatt ctcgcagaac tttttggtgt 94920 atttctttag aaatataaat ttaggttcgc gtggtgtatc tttcagatca tttagtgtga 94980 tataactgat tcgcgccaga aagtacatgg taaaagcgac acaaagaatc aaaattaatt 95040 gcagcatagc taactccata tgggtgtgaa ggcaaacata tttataacaa tcgtttggtt 95100 ttgggtttgc ccatgagagt gatattgaca ttgacacctg cttttttcat gcgggtaatc 95160 atgtcttgcg tcccagtaga cgaaccatcc cataatgcaa ttccaaagac ctcaagacct 95220 ttttgtttgg ccagggtcat agctttgtct aacatatctt tgttacgttg gtttcctgcg 95280 cctttcccat atatcgtgtg ataattctta gggatctcca ttggtgtaac atggacataa 95340 ttgatttcac accagtcacg agatatcaag tccacaccaa ccgcttcacc ttctataaaa 95400 gtttcgatct cgtggggatc taacaattca tccagtttgg cgaagatttt atcccgctca 95460 gttatagaac gggaacccgt tataagaacg atatacttct tcatagaact cacagcgccc 95520 caagattgcc gattacatat aggctgcaca agggagtccc tgatgaacga ggttctatgc 95580 tcattcccga gaggcggatc agttccagca aaccgtcggt ggtctgatac gctcgagtcg 95640 aaccgtttgg acgatatagc tccaactcgg ttcgcccttc ctttaatgcg ttacggatgc 95700 gtgtgaatac gctgtgggct tgatattttt gacgtagaat atctaaacgg gtgatgagat 95760 ttcgactgcg gctgcgacgt cccgttgacg aaacaactaa tttcatttct ggtgttttac 95820 aagccatgtt atagtcctct atttgtaggg gttgggtatg attttaacat acccgttcaa 95880 atggtttaga acaaattaca gatcttggca ctgatcgcaa tattcgtcgt atgtgaatgt 95940 ctcatcacac aggccgtcac gcatcatatc ggccttggct tcgccaaata ttttcagggt 96000 gataacgttg ccgtctaaat ctttacgaag ttcgttcggc ttggtttcta tgaagtcgaa 96060 caccacaaag aacccttcgg tgacatattt gatggttttg ttgctcagct tacggatgcc 96120 accattcttt ttgaagatag aggtgcggag gttttcgaat tcggccagat tgtcatcgtg 96180 attcttgatg gcgttcagca ttgcgtcaag gtcgatttca ggacgaagca ttttgacctg 96240 atcttcgcgg tcataagaag tgaaagattc tatgttggtg atgcccagag cgtttttaac 96300 aaacgcgtca aatttggtga aattgttgaa tgcccagacg gagattttta cggttgtcat 96360 gatgtagttc cttcatttca gagtcagtgt tgtgctgctt atggaatgaa gtatacgggg 96420 tttattgaag aagtaaaccc cgtatattga ataaatttta aatttatttg aagcgatcag 96480 gaagagtgtc gtgaacctca gcgctcagca ccaggaactt gccgtcttta gtagggaagc 96540 agtagtcttt cttgatgtgg cgcatgtgtt cagccgtagc cgctacacag tcgttagtca 96600 cgtcggtctt ctcacctacc cacatactgg ttttggtatt caatgtacct tggaagatag 96660 tgcccgtcaa tgggcttgct ccaatctttt tgattctcat aatttctccc aagtccatgt 96720 ttgcgccttg gcttttccga ctactggaac gttacggtgc atgtttctga agctgcctgt 96780 ctgataaaaa cagattctga tgcgttcatt ttcggtatgc tgtgcccaaa catgatgacc 96840 gtcagggtat ggatcatgac cagtgctacc gccttgtagg gctgttttgg taacgacata 96900 atgcccttgc atgtaaccga agaatccctc aggggtgata taaccagagt ccgtttgcca 96960 atctcccttg caattagaat acaagaaatg tttaggcacc tgagtttcaa tggtcatttc 97020 ttctgtgaga acgaacacat cgccgacttg aagcagtggt aaattgctca tatattaatc 97080 tctcacatgt tgctgatttt aaataaagtc ggaacatagc acgggtgttg ttcacaggac 97140 atgaaggtat caaaacggga acctttaacc aagccaggca gttcgccttt cttcaggaga 97200 tcacgcacta actcttgcgt gtcataccaa ctttttgctg gattggattg ggcttctgaa 97260 actcggattt tcaactcccc agtcgaataa tatttaccgc tttccttcat ataataaagg 97320 ttgacggtca gatattgagg agaatctatt tcttcccaac cgttatcaac caagtcttgg 97380 cggtcattgt cgtgactttg ataatcaatg tcaccgctgg ccaatttata gcatttgaaa 97440 atgcgaaaac cttcgatagg tgtatcgatg tcgctacgaa aaaactggga acgtcctgga 97500 ctaataaaga tataattttg tttagacatg atgtagttct cacttcaaag tgttatgttg 97560 tgacagttgt cttcttgcgt cgctatttcc caacgaatga ttgtgccatc tatttggggt 97620 atgtcgcgat tcaaattact tcctgggaga taaaggtctg gattcagata atatctcgtt 97680 tcaccgtctt caaatatttt ttgagccgtg aaaacttcga ttttagattc caaatagttc 97740 ttatccagat atatcttacg gattagagtc ggcatcatcc cacccccatt cgtcttccca 97800 agcctgacgt ggagtttttc cagattcata atcttcacgc caagcatctg catcagcggc 97860 agaaccatgt tgagaacggg caacgcgctc taattcggta tgccattctg caaagttgga 97920 gttttcattg ttaagagttt cttttgccat gagttgtatt cctattgtga aagttgggta 97980 atgatggttc attacccatt tattgaaaac attaacaatt atctttagac tcgtcttcac 98040 aatttgggtg ataaaacgtt cccagtttag tatggatgac gtccatgtgg gcattgattc 98100 tatcgatgat atcgtcctgc tctccttgta tgttaaggat agcaccaaca agacctggat 98160 tgtgtgttga tttttcttca gaatcagatt cgggaaattc accatctaat tgtcgacgaa 98220 tattgatcac attagtgagg atgtcaaaaa gacgttcttt ttgggtgcgg gaattaatga 98280 ggatttgtga cacggattgt tcagaggtaa tatttcgggt tgtcatgact gatactcctg 98340 ttgtaagaaa gttatatcgt acaacaggaa ttgttattga actattcgcg tattaaatcg 98400 ttacgataaa caatcacgta ttttgagaaa catatttcag atatgcgtat ttgtaacctt 98460 cctcggtgag tacacacaga tgtgtatctc gaccttttgg tacgttttta acatcaactc 98520 gtttacaaaa ccccagggag gccaattcgg cttctccaga tttagcaggt atttccccag 98580 cttcacgagg tccaaaccag aaaagaacga atagagtatc gactgcaccg ccagataatt 98640 gatgagacat tttaacctcc tttgataaat gaggctttat tatcttacat atccctataa 98700 agaaaaaccc cgccgaagcg gggtttatta tcaaaacctg tcgattagaa cagagatttg 98760 atcagacctt tgcggaaata cgggttgctg tcttgagcaa taccgtcagc agtcacgtaa 98820 acctgcgggt cttggttagc cggaatctgt acgaacgggt tagcacagat gccgtaacgg 98880 gttttgaacg ccatacgcgg agcgaaggtg gtttcaccct gggtgcggta catttccagc 98940 ggcacatacg gcgcgaagaa gataccagca tccagcgcag ttgcgccttt gtatgccaga 99000 gtgatatatt ctgctacagc atacgggtca acatagacgc gcataccgtt ggacagaaca 99060 ccagcgaatg tctggccagt cgggtcaaca gccagtttag tgttttcctg cagaaccgga 99120 gcatagtcca gcatgccaga catcgccaga gcggatgcca cgttcggaga acacagaaca 99180 cggttgcctt taccacgacg ggtgtcaaca ccgataccgt tcgcttcaac ttccagcatg 99240 aaagtcagga acttccattt ttccagcgcc caacgaccag agatgtcctg cgcgatatca 99300 acaacaccgt tggtgccgaa ttttttgaag cgaacagcac tgaagttcat ggtacggatg 99360 aattcgcggt tcatttccgc ctgaatttca gttaccatca cgtcagacag gatattatcc 99420 acgtcttcgc cgtgaattgc catcatgtcc tgacgcagtt catggctgta atcagcgtac 99480 aggccgcgag acttggcagt aacggtcgct ttctgaacgg tgataccaac acgcgcccac 99540 ggattggtgg tagtacccag cagttcagcg tcacttgacg gcataccttt accgatagtg 99600 gtcacgacag agccggaacc ttcgatctca gcctgactaa agcctgacgg gtcgccagcc 99660 tgtacagtac catcaccgga atagccggaa tcggcttcct gcatgaacag ttctttacga 99720 gactgtgcgg tgttggaact gtcaccaata ccctggcgag cgcgcagtgc aaagatctga 99780 ccgtcaggac cagacagcgg ctgaacaccg aagaagtcca tcgcgatgtt gatcggcgcc 99840 agacgttttg ccatgtcgat cagaactggc tgccatttac cgacagtgct gttcacagaa 99900 ccaggtgcgt cagattcgcc caggtttttt gcgttccatt cagcctggtt ctgcatcaga 99960 cggatggtta cgttttcggc agacagaggt tgaatagctt cagattcttt ttggagaact 100020 ggcagccact gtttgcgcat ttcttcggtt acaagtttct tagtcatgat gctcgttcct 100080 tacattgata ttcagttaag ttgaaattac ttagtagttc aaaatcaagc cccctttcga 100140 gggctgtggc tgctaaaatt agccgttcag caaagcactg atctggcgac ggacggcttc 100200 gttgacttct ttgccaactt cgtctttgtc gtcatcgtca tcgtcatcat cgtcggcttc 100260 accttctttc ttcggttttt taccttcttt gatgtctttt tcagacttgt cgccatccgg 100320 cttgcctttt tcattgtctt tgccgacttt atcagagaag tcatctttgc cttctaccag 100380 gttacggaag gtgcgcacac gggattcaaa ttcagactcg gtctggaatt caataccttc 100440 cagcaggttg acaacagtgt ctttcttggt gtcaaccatg ccttcacaaa tgcgatcaat 100500 tacgtcggtg cgctggcgtt tggtttcact ttctttgagc tgagccaatt cagtattggc 100560 aatgctggcg cgttgttctg cttcagcaag gcgactggtg agggcggcaa tctgaccgtc 100620 tgggtcagta gcgaaactca cacctgcttc tttcagcacg ttggagaaac cagtgaggaa 100680 gcgttcagca gcttcagttt tgatctgagc gtcaatagct ggggcatttt tgttagccca 100740 ttcttcaacc accgcgttga ggaacgaatc aactttttcc gccaactgaa gagtgaaatt 100800 ttctttaagg tctgcgactt ctttctggtg ggcttctacc agagtcaggc gctcaacgtt 100860 accagccgct tcagtttctt gaatagcttg cagacgggcg gcttcaactt tagattccag 100920 cagaccagat actttgtcca agaaatcggt gctgaggcca ttaacgcctt caaacagttt 100980 ttgcaattca ggtttcatga tagtttcctt ctgaacgatt tttcagtatt tagtgagctg 101040 aaattcagcc cagatgattc aatgctgcat caaggcggcg caggaagtcg tcttctactt 101100 gaatattggc tttcaccaac tgatcaacaa cgtttccttt aacatcccga ggcatccaaa 101160 tacccgaagc ctcatcaagc tgccattcaa cagattcact cacagcctta acataacaaa 101220 cttgtccaga aggacggtcg actgcatcaa cagcggtgag cataaagcca ggttgaacgt 101280 cgtcataacc gtttactgac ttggtctcac ccagaccacg cgtagacacg gccagattga 101340 agtctgcttc agccaatgca cgtatgattt ggccttttgg tgtatttaaa attcgcgccc 101400 gaccgatggc attagtgcct tcccagcgaa gggattcggt tttgagcgca gcttccacca 101460 gattagggaa aggatagtca ggatgtgtga cttcaccgat tgcgcgacga tcttggatat 101520 actctttgtc gtatgcttcg acagcaggaa tacccacttt ctgcagatca tagttacgcc 101580 cgttacggtt gacttggtta cacatcacaa acggaccttc gatgaacatg gccttcccac 101640 cagttgaggt tgtggcctca ccgatttgaa gatccttccc tatcgctgtg atctcacgca 101700 acagtttcat cataaactcc ttacttgttc ttactcagtc ccatcatttt gcggaacttc 101760 atagcctttt tcttacgacg ctcgattttt cgttggtagc ccatacccat acgctttttg 101820 gagcgaagag cttttcggtt gccgattttg cgcacacgac gttcgctggc atccatgact 101880 tcacaacgtg aaccatcagc cgacaatttg aacccagggg cacatttcaa gcggcggcgg 101940 cgtttaccac gagcgttcac tttatcgatg actcgctgct cgtccatacg agaggccagg 102000 aaatcagcga acgtggcgat ctctgtgatt tccatcatgc atctccttac tggccgttgt 102060 tgtttgaatt catatcagct gcgatagaat ccagaacata tgctgtgcct tggtttaata 102120 gttcttgact acgtgcatca agttccatgt tgcattctgc aacagcagtt tcagtgtcac 102180 cgtcaattac tgcacgaacg atatcaattg cgctcatgat tttgatctcc gaattaattt 102240 tctatattta gttgaacttt aaatactatc gtctgttgaa ccagagaatg ggatagtctc 102300 aggtttaaac ttcaacggac taacatctga accgctataa ttgccagttt catctgcttg 102360 aaccttcgga tagagacctt tcttcttctc ttccgcgatc ttcgtttgtt gttctttaac 102420 ttcttcatca gacatacgca atacatttct catgacgtag tctatggaga aaatggaacc 102480 aacaaatggc tcaacagtgt tcaatgaagc cagacgatca ttcaagatag cgttttcttg 102540 ttgttcacga atgtaactat cggatgtgaa ttcaaacttt ataaacggtt tgatcttctc 102600 attccaatcc ttttcatccg taacgccttt caaaattaac tggcggcgca agaattccat 102660 aaagaaatgg gagtaacggc gtcgtaaccc agcacagaac ttgctgaagc gcagctcttc 102720 ctgtgtaatc tccgcaaggt tagaaccccc aatgttaata gatccttcct cttggaggcg 102780 gctcttaggg atcattagag catcatagag tttttcacgg aaatagttca cgtgatccat 102840 ttcgcccaat tgattcccac ccccaacagt cgcaatctct gtagcattct gaccttcgcg 102900 gcgcggcaac caataatcct ctgcaatacc cataagatgg gcattacctg ttatcttacc 102960 agtggtgcgg tcatatgcgt tgcggttttt gaatttaccc atcatcatgg tcatgtattc 103020 ttcagcagat ttcttaccga gagtaccgac gtcaagatag aatgcgcgtt tctcaggggc 103080 gcgagtgatg gcataaatta cagtcgcatc ttcagtcgta accaggttgt tcaacgggcg 103140 gattgcagga tttaaaagcc ctgggacaat accgttagcc aatggttctt caccactatc 103200 gatataaacg atactttcgt catcaaacac gagttcttgt tgtgaaggtt ggaagttttg 103260 agaagtacct gattgaccag tgaattggtt tcgattataa ttcggattgt aatagtattt 103320 cagcgttaca gattcgatcg cttctatacc accttcacgc attgcctttt caacgatgta 103380 cacaggacga atacaacgag aatccagcat gaccaatttc ttgatcccgc ccttcttatt 103440 cgttgggtca acaatcacat gatacgcttg tcgaccatct acataccatt tccgaatctt 103500 ttgatacgcc gtattttcaa aatccatcaa atgaatcact tctttgaaac attcggtgat 103560 agattctttg actgattcag aaataccatc aactttgtca agattgactg tcaccggagt 103620 ttcgtcttcc tcacatgtga caacgtcatt aacaatgatg tccacagctt tgcggatttc 103680 tggctgctgg gccatggact gatattcttc cacaactgtt ttaacgctga gaagttcact 103740 ctcaacgcca acatagttgt aggtgtttgc accgccctga aggattatag aaccgtcttg 103800 agcatcgtcc agagcaacaa ctgtcgcctt ggtgagcaac aattcatctt gtttttgggc 103860 taacttatcg gtgtcgactt tggcattgac taaaccgccg ccaccaaaca aaccgaagaa 103920 ccccatgccg tatccagcca tgatctaagt cctcaacgtt ttcttgtaat tagtgagggg 103980 gaataacatt cccccagcac cgaggacatt acaatgactt gtcagaaacg gcttggaaat 104040 aacgcaagtc gacagtgaac tgtgtgtaag agtccattgc cgacatatcg agttccagtt 104100 ggccgaggtt ttgaggccag ccgccctgta aagtccatgt cttagtcacg ttgtcattcg 104160 cgtccagaag ttccatgatg atatcacgga aataatcatc tggattcgcg ctggcgcggt 104220 tgttttcact accgttgatg aattgctgcc acacttcaaa agcattgtat ggagcgttgt 104280 tcaccacgtt aatgaacgtc acaggaagcg cttcgaaacg acgatcccct gggaacggaa 104340 gttcacgacc accccagggc accagaattt cgcccagctg acctgttggg gtgttggtgg 104400 ttacagccag caaggacacg tcacgaattg tgtcggaacc agcaacaaaa gaaggaaagt 104460 ttacagtcac acgccagcgg tgttggcgtt gtacgccgcc ccctcgtgac atggctgcgc 104520 gaaactcatt gactgtcgcc atttttatat ctccaaataa gagtacacaa ttctaattag 104580 tcgtcaatct tttaatcttc atggaagaaa aatcaaatcc gtggtcaaca ttgcttaaaa 104640 cgggttcgat ttcacacaat tcccaacggg gatctatgag agaaacaaga ccaatgtgtt 104700 cacctgtgga tgtcaatttt gctgcagttt tacccagcat atgacttcca tcattaccgc 104760 ctttattcat gttgtaaccc atctcataag aattatattg agagatgagt tgcttctcta 104820 attcccattt atggacttca tcggtctgag caattacaac gaaagtaaat ccagatgttc 104880 catacttacg catggcatca tacaattcac tttggactcc atgatgaaaa gcattcgcaa 104940 aatgctgatc atatcttcgt tgtgggtcat tggtcacacc gatgtagacc tttccattag 105000 ttatcgtttc aattttgtat gcgtatatca ttcaataact caaatcaata agacaaagga 105060 aaaccccgcc gaagcggggt tggtcattta tgaagcagca acgatgccgc caccggattc 105120 gatttcgctg aactccatat ctggtcgaac tgcagcaaaa tccaaataaa tccagttaat 105180 gctgtactca ggcttcaacc aaataccagc aaccatttgg tttgccgcaa tgatatcagc 105240 agtgttgttg tcttcatcac atttgacttt accatcgtaa atcgcgccca tatttgccag 105300 ctggcgaata tatggacgaa ccgcattgct gaacagacca cgtgtaaacg cgtcattgtt 105360 ctcaccaaga tagtatttgg cgattgcggc gatgttctgc tcagccatga tgaacaggcc 105420 acgaacgttg atacggtcaa acgccgacgg gcgggtcagg ccagttttgt caccatacag 105480 gacgatgcct tcattggaga aggttacgat gctgttgatc tggttgcggt acaacacagc 105540 acgttcatca gaagatgcag accacgccat tcgattatag ttgttgtatt taccacggtt 105600 gtggaacgcc ggagatttgt agatacccgc gatttcaatg cttcgcgccc aaacacctgc 105660 ggtgccacca caagccggaa tccaacgcat tttgtcgttg tacttgtcgt acacatatgc 105720 ccagttatca tccatgaaga aataagaaga gtcgcgaaca aggctttcac gccaagcaac 105780 gacatcatcc atttcacgac cacggttgcc aacaaccgta tcacggagcg gggatacgaa 105840 agatacggta tcttttcgct cagtagataa gtcgatcaat gcttgttgct caatcagttc 105900 ttcacagtac gcaaatactg gcttcgcatc atatgcttca gcattgttca agacttggat 105960 agctgccacg cggttgatgt tataatcgtc tacgccgcct tctaattcaa cgacacctgc 106020 aaccagttcg ctcgcgaagg tatacaccca atttgaagta tcgttgatca cgtctttgaa 106080 gtacgcattc gcgccatcgg attttttaga accctgggtg ttctgcatga gttcgtattt 106140 ttcgataata gaaccagaag cgccaacagt agtgattacg gctgttgcag tcagtccttt 106200 atcatcagga acgatagctg taacggcctg aggaccgata gctttatggg tcacgatgac 106260 agtgttggac ttcacgacaa cagaagaata aacacttgtc agggaagtta gcgctgtacc 106320 gattttggtt gccaaagtgg ctggagtatc agtatccaga tatgcgatat cttcacctgc 106380 cacactgatg gtgccagcag cagtagccgt accagaaacg gagatacggt caacctgacc 106440 gactgcgcca gcagagtcgg taatgcggcc aactttgtct acgacaacta catggaattc 106500 accagactga ggtgcgtatg caaagttatt acggaattcc caagtcgaga acccagcagc 106560 atcacaaaca ttgatagcaa tatcattacc cagggaacct ggataacgac cagtccaagt 106620 gatggacgcc gaaggacttg ctgtttcaaa atccagtttg tttttgatcg caatcgctgt 106680 ctgacctttg gtaacagagt tcttggctag aggaccaaca acacgggtca cccatgccat 106740 agagctgtaa gacaaaaagt ccgcgattac gagaaaatcg gtcgcagtac tgtcgttggg 106800 tttgaagaat ttcttcacca aacctgtctc accaccagtc accagcactg gaagttcaac 106860 ttcaccccat tgaaatttgc cgacggtcgc gccctgaaca acaacggacg gagacgtctg 106920 aagcgtggca tcacgctcag tccactgaac ggacggcgca acgctgaagc tttgagttgc 106980 cataatatca ttccttctcg gtagagtttc gctcaatttg aaagatattt agtgatcaat 107040 tcttaaacca ctcatccatg gtcatccctg acatttcgtt gaaaacttga atacccccga 107100 aaccaggcaa atgctcagtt tcggatgggg tgtctccaac gactaaaccg ccaaatggga 107160 atacctgctg agattcagtt gaagacattc ggtttctcat gtcctgagaa atacttgtag 107220 atgtcaaatc actgaaccat tcttgtttta ccgcccatga atataagacc aacggcatga 107280 cacagtcatc gtgacaaccg tcatcggctt cataccgagc gcctttgaac acaaatgtac 107340 tgagttcatc tatcgtgtcc tggtcttcta tcaccaacat ttctttctca atgagcgctt 107400 tcaggttagc acaaccgata gatcggactt ttctgttggt attgatacca ggttccggtt 107460 tacgcccacc aatccgtttc cccgtccctt tgttatctgt tgatgtgaat atgatttctg 107520 gatattctat ctcttgataa agaattgtaa taacctgacc gccgacgtcg ttgtttgttt 107580 caacaaggac aggacattcc ccgtattcgg tgcacatatc agctatcgtg tatgcataca 107640 tcataggagg tatcgtatta ttcctgtact tggctgctat gacatgcgga tattcagtta 107700 tatccagaat tgttaagacg gaataatctc cttccacccc cttcccagtg tccgcaatcc 107760 caaagtagag acgttgtggg tcgtattcct tataaatctt ggtgaattca ttaggttccc 107820 gatacaactt ggacgtcatt ttatctaagc atttggccgg aatcaatgaa cccacggaac 107880 cacggaactt aatgccaaat tcttgatcga aacgagcatc ccccagacgg gcacgttgtt 107940 tggtttccca atctggatct ttggtatatg ccggaacctt ataccatggg acttcagtta 108000 ggtggaagtc gttgtattgt ggatggcgcg gatctgcttt ggtgacaata tcatagaaca 108060 accctcgctg gcctttcgga gtacttgtca aaatacagcg tgatgtatcg gcagatgcaa 108120 tggctgggaa agttgattcc caaaattcaa agtcgttttc gataaacgcg acttcgtcaa 108180 cgtacaagag cgatacagaa cgaccacgga tggagtccga agacgtggca taagcgtata 108240 tcttagaacc attttcaaac tctatcaggg tagaaccaaa cttctcacaa ccctgctgaa 108300 ggaagaatgg aaggtcttgg tatgcctttc tgatacggtc aagaatttct atcgcttgtt 108360 tctctttgtt tgccagtact gcgatttcct tatcagaatg gaacatcgca taccaaagaa 108420 gaaacgccgc caccacggtc gtgttatgac tgagaaagcc attcgtgtaa taacgttgat 108480 cactagattt gacctgcaga tcgtacatat ggtgatattc accagtctgc caaatctcac 108540 ggatttcttc tggaccttct gtcgtcatga tgtatgaccc agcattcagg tctttggcaa 108600 atgtctcctt catgtccgga gtgaagaaca tatgttcatc ggccacgtta attcgccttc 108660 cggtaactgt gacaataacg aattccgcat atttcttcgt cttatgcgct gcgataaccg 108720 gaacccagcc actatcggat tgtacaaagt aacgtttgcc gaagcggctg tccacgaact 108780 tgtcatggtt gccaatggta ttcagcggca cagcgtggtt gacgtcctcg aatcggctgt 108840 gaagctcccc tatggtcagg agcaactcct cttggctgag agtatcgtaa actgtgacaa 108900 gcgtgtcgcc ttttacacat tttccagact gacgagcctg gacgaccgca ttgaatcgat 108960 agtcctgaaa gtcatggaac aactgtttct gataatcatg catatcgaaa aggataaagc 109020 ctttatcgat cgtggttatc ttgtaatagt tggcggcgaa gtagtgtgca tccatagaac 109080 attcaacgaa ttcgtcttct tgttcatctg tcagcattaa ctcgactcga ggagcacgca 109140 cagaaggttt gcgcatgaac gtttggtcca tacgcaattt cacatcgtct attttgaacc 109200 ccgttttaat tggggcatat tctatatcac gcttctgata cgccatcgtc ttcttccttc 109260 acatcaactg tttcaccatc aatgatttca tcttctggtt gttgtgcggc ctttgcttgt 109320 gctctttctt cagcgcgacg gcgggcatct tcaatcgtct tcaataaatc gcgagaagat 109380 cgcgcctttt tcccaaccga tactgttgtt gttccgtctg gtgaagttgt aacatccact 109440 gtcgtgtcat caacaggtgg ttctttatca cctgttactg ccttgatggt tttctggttt 109500 tccatcaagt ctttattcag accgcgcatg agttcaccca attcacggaa aacagaaaat 109560 gctcgcggag cttctgtgga tgcagccaat ttagcggctt gtcccatcat gaacattgtg 109620 gcttcttgca tggcatatgt tgtgtcgcgt atccgtttgt aatccgttgt agcatcagtg 109680 tccgcaaact caggtacttt ggattccttg gaagcaatat cctccaatga aggaggttca 109740 ggaatcggct gatacccttc cggacgttca ccaaaccatt cacctgtatt ttcatcgaag 109800 tcaatacctg gacgaggggc gacagcctcc attgcctcct tcccaacttc gtctcgggca 109860 gtcaccgcat caagtgtggc gagtaacctt tctgacatat tgctcatgat caatcctccg 109920 gatgatgtat gccgtcttta tcaactcgga accactcagg aagttccgac catggcatgt 109980 tcaaatcatt agacatttca ataattatct ctttgatgac gtttggatcc ccaccgcccg 110040 aaccatcatc aacccaataa tcttctccat agatgtgtcc atgtaattga aaattaaagg 110100 tgcaatctat atggggtgat tctgttgcgt ctccttccca gttgtcagaa atcgtgtgat 110160 ttaccaacat tatcttcacg ttctgatctt gagataaagt atcgttgtct tttatctgac 110220 aatcaataga aggagtgaac acagaataaa tttgttccaa cacctgtagc atttcgacca 110280 gtttcttcgt tctgatgtta tattcaaaat ctataatgat cggaatgcgt tgtttggacc 110340 gcgcagttgc agtcgatatc tgattatgat acgacttggt cacctgttta ttgatttcga 110400 actgaccaaa ggacattgtt gcaaatggca gcatattggc tggcacgttc ctgttgaggt 110460 cattacggcg gccaatggcc atatgcagcg ggatttccat caagccacgt tcggttttga 110520 cttttaaatc cgacatgata gcgttgaaaa catggatata tttcaacaac gattcatggt 110580 agaaatattt ttcaaatggt ctggccatga ttattccccg aagtctatct tcattttatt 110640 gggcgaaaga tctttctcta tttcgtccgc aaattggtta tctgtctgta gactggcatc 110700 tttatagaca ccatcgccgt ctagatcctg caatcgttta tcaatatcgt ctatttcaga 110760 tacacctgta tcgaaatctt cgttaccgta ttggaacaac gtacatggta gagaatatgt 110820 gtaccatttc ccaaattgca tgaattcttc atcgttattc gggttattca ctttaaatat 110880 tttgttagcc ataggcagat atatcaaatc accttcttga ggcatttgtt caaggcctgg 110940 accattacca ataacttctg aaaaacgacg acgagcaata gtgaaggtca cttcatcttg 111000 taattggata ccgccgaact tttcccacat ctgtgtgttg aagccttgat aatcctgcat 111060 gtacacttcg atgtcaaacg cttggtcgaa tttgtgttca gcctcgttta aaattgggta 111120 tttttcaaca atagaacgtg ggatatactt gacgtcaatc ccacgcaatt gtatcatctc 111180 gaccaccaag tcatcaatta atttttgagt accttgatgt gctgtatagt tgaaatattt 111240 tgaagtagcc atgactttac cctcaatttt gaaggtattt agtcaatcat taattctttt 111300 gaggaattga taaatgaagg ttgaagatat taaagaaact cgtgacggaa ggcgtgtgag 111360 aattatctgt gtagatgcta aaatcgccga tggttcatat aacattgtgg gtcttatcaa 111420 aggcgaaaag gataatgatt ttattgaatg gtgggacgaa aagaacgtgg ttgatggtta 111480 tattctagca aattcagatc cttccggacg cgacatcaag ttataaaaag aaaggcgggt 111540 tatcccgcct tctcttatcc catcataaaa tcgatagggt attgctgacc agtacgcaat 111600 tcttcctcca gccgctctat ctcggtctcg gcctcactga acatactatc accatccagt 111660 tcgataccac cagggagacg gatgcctctt gccttcttaa gcacctctgc ccaacggcgc 111720 ttgaccaatg cagtcgcata cgctttcaac cacatatcat tccatgcttc agcgttttct 111780 tccgattcgg ggtcgatatt ttgataacaa cgaaaagcca gagtttcatc aacaatggca 111840 gcaaactgcg ggtaaaggcg tcgctggaac ttcttgtaca caaaattacg gcgaacattt 111900 aagacgcttg tgatatccga caggcgttgt tgcatggaaa cataatcaat gagacgaata 111960 gaaaccagcg ctgctttggg gacaagcatt gcttgagcca tttgccattg aggagttgcc 112020 cagtttccga ttgactcaat aggaggtcca gggataactt caatcacatc gtcaatatca 112080 tcgggaaatt cgatatatcc cttgtcgata tcttcttgtt taacttggta caggaagaac 112140 gcatcttggc taccatcacg atgatattcc caaaatttct gcagagcatc atcgactgca 112200 tcttcgactt gtgaactgtc aaggttaatt tggatcacag gagcgcccaa tttacgcaag 112260 acataattca taaaagattt tttgtctcga atcttattga cggccattgt tattcccctt 112320 ttgctgcaaa tcagatacag taatccgcag tgtgcgaaca tcatctgaaa gactgctgct 112380 attgagtttt aactcagcca tgttttgttt gacatatgcg aggtcagtat tcatgatcgc 112440 catacgttca ctcatgtcat tcactttctg aagaacttga tccatcttgt tggaatctcg 112500 ttccaataca ttcacgcgcg tttccatccc gcccatgaac caaaggaacg atgctgccga 112560 gaccaatgca gaagccacga cagcggttaa gataccacgg atgtcaagcc ccgttctttc 112620 agcttgcgtc gccattctga cctccttcgg ggatttcgat ccccaacttt tcggccatca 112680 ttttgattgt cgcctccaga ttagatatct ggtttgattg ttcaacaatg gtggcttcac 112740 gggtttcatt gcgttgacgg gcttgcaatg cagccatgcc agcggcgtga tcggtgcaaa 112800 taatcgcgcc agggcaagaa ctgcttctca acatggatgc gtgcccctgt actttcactc 112860 cacgcatatc tttatcctct attggtttgg tgggctttac gcccaccttt caacattatt 112920 tatgccagag caataagacg gaagtctttg aatgatggag gagcaacgcg gttcccccgt 112980 acaagcgctc ggactttcag gccaacaaac gggttattgc tcgccacagt cttgtcatac 113040 tcatattcaa agaatgtgga accgtcgtta accagaggcg aagttggggt gacgtcttcc 113100 caagccacac tatccatctc ttgccctgct cgtagaagtt tcacctgcac cttcatcgaa 113160 gactgagatg ggagcattgc accaaagaac aacttcacag tagaacacgg attatcaaat 113220 ccgatgtcct ttgtcacgta tttgaagaca tcttcgaatg gatccacacc gtatgagttg 113280 aaaatcacac ttaggtcatc accatcaatc attggagcag tgtacacgtt gttttcacta 113340 cgcgtcatgg tggctcggat ttggaaatcc ccgacctgac gatagatacc ttcagtcggc 113400 aatgccacgt cagtgtcagt ttcaaactca gcccaatcag acatagaatt tgaagtggca 113460 tcgcgataac ggtattccaa tttcataatt gaaccttcca gagccgaatt ggtaacgctg 113520 gcatagaaca tatcaaccag ataattgccc aagaaagaag cattatctcc accgatttgt 113580 ccattgctgt ctgctgccgc accgacgtca atcttgaatg aagtatagct cgcatctgtc 113640 acagtaaacg ttttgttaag ttgttcagga gtaaagccac aaccgcctgt caattcagaa 113700 agagtgacat tgttcccagc aaccaaacca tgaccaggtg caaacacagt cacaacagaa 113760 gacccgctta cgcagttcag agtgttcaat cccaacggac gttgttttgg cccgagcttc 113820 ggatcaaatg ttacaacgtt ctgtcccgca gcgaagttac aacgatatat gcggaatttc 113880 atatcagcca tttggtttgg agaccatgta gaaccgtttg aagaagtgaa gaacacccct 113940 gtatacggtt gtttggcgat atattcgttg gacagaaggt ttttcttgcc catttccgcg 114000 atatacgcgt tgtaatcctg agtattcgcc aacaaaacga tagcaaactc agtcgatgct 114060 tgcagataca ccggataatc aaaggtgaac ttcgtaccgc cggaagagtc tgtagagatc 114120 gtcacttcag atgggttcaa agtcttacga gtaatgactg tgtgagaagg taagccgttc 114180 tccatctcgc gaatttccag agtgatcgga acatcacgtg acttggtaga gaagaatact 114240 tccacgcctt cgatatactc gccgccattc ttagtcgcca ccataaacga ttgggcgatc 114300 ggatcacgcc attggtcgac cacaacttca gaagtgctgg tttcggtgcg agtactggca 114360 gtgtaaccca ggacacgagt gttgacaaag gtcttttgaa taccttgttt cttaccgaaa 114420 gatttatgaa caatttctgc attggtcagt gtatcatccg cagatttact gtcaacaggg 114480 ctatccgtta agcggaacac gttgtcgcct gtgttgaact tgattgtatc gttctgtgga 114540 acgcggaata cacctttaac agcaccattg gcatcagtgg tgatcgggtc tccgaaatta 114600 ccgccattcg gtttgcaata cagattgacg tcacgaccag agaagaacgc atacatacga 114660 gtgaaaggtc gcagcccaga tgcgtcgaaa gaaatatcga tctcgcgcat gtatgggata 114720 acttgcgtct ccacaatctg ttcaccagtc atggtcgtgg ttgttttgtc cgtgtatgta 114780 tatgtggtga catcacgggc agaaacagtc gtgcggtaac gatatcccca ccacacacca 114840 ccagcaccat gcggttccca aacacgatca gaaacagaaa cagtacgcca tgttccgtac 114900 actgaacctt cttgtacagt accacgggtg ttgatcgttt cattgataat acgcggtgca 114960 acataatagt tttcgaacca gtagtctgtg gtcgggttaa tcttcaagaa accttcccaa 115020 ttgaatactg catacgggtt aacgttgatc gtcgtcgtcg catattcttg gttcaccgag 115080 atttcaggcg tgtaattaca aaccaccatc ccatccatca ctttgttcca gccaaccgga 115140 gtcatgtcaa caacgttttg ttgtacaaac gggcgcagac gtccgttttc ggtatcgata 115200 gaacccatcc aatcttcaga caagtcatca atcaacctga agtctttgaa cggatcagct 115260 gcgataccat ttttgaaacg aggattaccc gtaatggggt cgaacacttg ctgtgtcatc 115320 gctgaagatt ccagctgtga cagagaggta tagtattcaa cattggaaat acgggtttcc 115380 agtttaccga tatcgcgcat cgtataacga cgattatcaa tagtgcgaat ttggatatca 115440 tcaatattcg gtgtatacgg cgggatcaac aattcataca aacgcatagc gttcgctggg 115500 attgctggag aagccagatt attagaacta attcctcgag ccacaccaaa cacaccgttg 115560 tctgccagat aaatcgcgtc gatacgcggc agataatatt ctgtgtccag aataactgca 115620 gtgtttggac gaaccatatc tgtgtcagaa gttccgttgg tgattttcgg acggaaatcc 115680 aaactatctg ccaggccgta caccgcgcct gatgtagaag atgtataatt cgggatatct 115740 ttataatcca tcgaagtata cgaatcagca gagaagaaat caccggaact gtgggcgaag 115800 tattgataca ccactgtata cgtccctgag attgctccag cgctggataa caagttagac 115860 ttgtaatacc ctgcatcacg ctgtccgcca tctaggacga agctggaggt cacgtcttcg 115920 ccagtatcgt ttttgaccga taccaatttc caaccatcgt gattcgccaa aggacggcta 115980 gtctgcgagg tgaacgtcac tgtttcagtt gtttcagtga tggtcttcgt tttgattgtg 116040 gccgtggtac gaatcatcag cgccagcaaa ttgattgact ggttagcatt accactgccc 116100 agagaaatct gcagcgccga accgaccgga gaaccagtca aagacaaaga accagagata 116160 tcgaactgcg cttcagaacc atctgatttc gctgcagagt acaacgaaaa ttctggggaa 116220 aaactatatc ccaatggagc agaaatagaa cccgcgccgc tgttgtccaa cgtcacttta 116280 tacgttctga gaacagtgta gttgatatcc acggagccag ttggtgctaa agtcttgaca 116340 ccgaataccg gaagagagaa gatcagatct atcatagaac tctggttaaa ctgattggat 116400 tcaagttcag cagagaacat ggtgataccg ctttcttcgt aagacacttt ggtgatagtg 116460 gatgcatcgc cagtaacgac caggtcgcgc atatacagac gaaattctgt tgaattacgt 116520 tcagctgata tacaaagtgc tgtagcctgg gtaacgcctg aagcattcag taatttgtat 116580 cgaacggtgc gggatatcac tggcacacct ttagaattct tagtgaccag ataattgcct 116640 gtggccaccg caacaggggt gttgttcagg acatcggtat cccgcgcctt atcaacgatc 116700 accaactctt ccccgacgtt ttcgatacgg cgaccgcgaa cataggaaat acctggtttc 116760 attacagaca cgaatttact ttcgtcgccg ccatcagcag cattgaatac accaccattg 116820 ttattgactt tcaggtgttc gcggatgtcg atctggtgcg ttgaaacgtt gtaatcgccg 116880 ttggtttcat acgtccgttg ggccaacgtg tcttccagaa tattataggt ggactgagtc 116940 accatagact ggattttacc atcacgaact ttggccagtt caacaaagtc ttcaaccaca 117000 gcatcataat caaatcgaga taagaccaga tctattcgaa gacgatgagc gcctggggct 117060 ttggagttaa tcgttccctg agcatttgaa taaagggatt cgtcttcaga ttcagtcacg 117120 atggtttcag tgactttaaa tccgacgcgg tgggaagacg tgttcgaagt tttatcaacg 117180 ataagagtcg cgtcatcaac gtctaggaac atcccacgaa tgaagtaaac gcctttcgtc 117240 atacgagcaa cgatagaacc agtcacagca gccgcgatcc cataaccaat acgaatgaaa 117300 ttatcattca cgtcgtaagt ctggaaatac agattatcgt taacatggaa tccgtcagca 117360 ttacccgctt cagtcatctc aaggatagcc agcattgtat caggagcaga cagatcacgt 117420 tcaagagaca gcacacgcgc tttggcgtta ttgtctttcc ccaaaacgta gagttcagaa 117480 ataccttcca gatcagtgaa ttcagtacca ccagccaaag tgaatttcaa agagactgcg 117540 gcgttagtga tcgtcaaacc gccagggata accatagaac catctttgaa caaatggttg 117600 cccagttttt caatttgatc ctgaagaata gtctgcatct gattcagttc gcgagtctga 117660 accttgatag gcatcggacg aaaaagaatc cgtgaaaaac gtttcccagg attccagtca 117720 tcccaatacg ggcgacggtt taaatttgta gattgcattt tgatgctcca tcgagtgcca 117780 ttttatagag atatttagta tacagccaat agatagtttt gaacttccag ttcctgtcag 117840 gttaacgaga catagcaaaa gaaagccccc ttattggggg cttgtatttt agattgttac 117900 gttagcaata ctttccgtga accaaccaga tggagtctta actaaagtag ccatcatctt 117960 agttgcatag tctaccctca aagcagtaaa ggctcctgcc acattaaagt ggaatctgtc 118020 cgttacagta ggcaatgttg tatcagcacg tttaagcacc accccaccac cagatgaatc 118080 agagataact gtcacacgct ggcccatata tccaccgcta aacccactaa gggtaagagt 118140 agtaccagaa ccagtgacta atacaatatc aacaccatct acaggaatag atgctagggt 118200 ctgagttgta gtgtacttat caacagcatt ctgactaacc cccaactgct gaatcttaac 118260 tggagtaccg ttgcggttga agttaattag gttggagtct ttgtttacgt aaaaagagta 118320 gttaggaata gcaccggatg cgagcattgc tgtttcatct actgactcta attctcgcaa 118380 ctctttgtga tagcggttgt agtttctgtt ctggatatac ttagcattcc attgagtaaa 118440 ccaaatacca ccaaaaccac ctgattcaga tgtagagatt acataaccat catcaccacc 118500 aggcattgat gcgatgtacc caacagaatc acttgtgttg atatccccag taggagctaa 118560 cccccaagta actaggtcac gactaatcca tactcggtag ttagtacgac caatagaatt 118620 atcacctaca ccattagcac aagtaaacgc ccaagtaaga acaccattaa ccccatcaaa 118680 aataggaacc aggtcaccct tactatccga tgtaactaaa tcagataagt gctgccagtt 118740 cttaaactga tgatcactga tatagaattt ctgaagccct ttaaggtctg tggtgtggta 118800 agcacgagag ttcatcacca tacgaccatc cggcaaaagg ttcagtccga cttccccacc 118860 agattcttcg gaactaagta cgtagtccat gctgtactta atgtcatact tcatgatggt 118920 aaggaaagaa tcaacccgtg aaccagtgac ggtagacaca atcattgcca tcttaccatc 118980 cggtaaaaca actggtttag ttggtgaagt ccagataaaa tctgccgttg ctggcttaag 119040 ggtagcagta aggttagctg gtgtacgcca tatagtagga gcttccgcat cacagtaggt 119100 aacatatatc tgggatgatg tattagggtc attgcctggc tgtgagtatc cccaacccaa 119160 ctggcctttg caggaagtaa agtaacagta tacccgacca tctgctgggt tatacacagc 119220 agcaatctca ccgttctgat acgtagcccc aaagttagct accactacct tagccgacca 119280 agaccaccca ttatcaatgg agtatttcat aacgatatta cattgctgat ctggagtagc 119340 accaatatct gtattgttac catgcaactc attacagaaa atcatcagag taccatcacc 119400 agttttaaca atctggggca tacggtagaa gacggtatcc gtagggttaa gtttatcaat 119460 agcaacgtct ggagcagacc atgctaagtt tttaccagag tgacgctgaa cgccacggat 119520 atggtgataa acattaggaa taacggttct caccatattc tcttggttct gccatgcagc 119580 ttcttcggca aattcttctt caatggtttt gccattagcc agtactacca tggatgcacc 119640 actggtactg ttaagctgtt ccttcagata agaagcaccc aagccaatcc aattatcatc 119700 actggatggt aaagagttct gaggtacaac tttaggtaat gaaccattcc aacgatactg 119760 gataccattg tgggtaagta catcattctt tgtggatact attgcaccag tagtaaaaga 119820 accaggtaat acattatatt cattgcgttg ggaagctagt tcgcccaggt ctacagaacc 119880 cccagagtgt acaagcagag cactggcgct aaggctaata accgtggttc ctgctggaat 119940 atctacaggc aaggaatacg ctctctgtgt ttccttgtca taaataacct tataaccaga 120000 caaggactgt cctgatttcg cataaacgac ttccgacttt ttgcacccaa atttacgggc 120060 gatgctatct ttattcgatt cttttgaagt agaacctttt ggttgagcaa attgcggatt 120120 cataataaga atctcctgtt tttctctagt aaataccctc cgaagagggg tatattttta 120180 aatagaagaa tccaatatac ggtaactaat taacttatta gggtctacag gattaatcag 120240 gttgtagtac cgtgaagcta cataatcatt ctcagaagag aacataccaa catacacttt 120300 agcacctaca ccagaacagg catccccacc agcattgcta tccgagaaga atgttaatga 120360 agaagttaat ccgaatatag aattaaatgg tacagctaaa taagcgcctc ggaatgaccg 120420 tctgattctc ttacccgtct gaatattaag aatactccac cagaaatatc caggtttagc 120480 accaatagct atatgatatg gcacaccact ttgtagttta aggtcgttag gtaaatcccc 120540 agataaaatt tgggttgtac catcgccccc caatagcaaa gcaattgttt gttttccaga 120600 agcgtctata actaattgaa gatgaagact gttggatgta tcactaaacc ctgaaccaat 120660 ggccatgaag ttaaatactt cagctccaga tatggtgggt actacaacag cagccatggt 120720 aataccttct ggacctgctg ttcttgaata cagtaattta tctttgttgg cttgtgatag 120780 tctcagacca tttacttgcc ctacagaaga tgggacactt acataaacag gtgtagtgct 120840 aacaccatca aatgtagggg tctcgttcat ggtttgcaaa ccagtcttgg aataattaac 120900 caatccgtta atgctcaggt cggaattggt ggggttgata atattgttat caccaataaa 120960 gttaatgccc atataaccag tctcaaccac accattaatg atgacactac aatcattaga 121020 caggaactga aaattgcctg cactagagtt agcacctgaa ccactattcg cggcataatt 121080 gagtcctacg aatccgttga taactgcatc acttttgtta aatacgatgt tgtagaaagt 121140 gttgttagca ttgatgccgt tacgattggt gttcaatccg ttcatggaaa ttgaatatga 121200 ctcgctaatc tcaataccat tcccgccaca atcttgtacc tcaataccat taataaccat 121260 attctggctg ttattaatag taatgcctgg gaactgtcct actgtaccat aaggttgcca 121320 gttagcccaa atgaatttac cgccaataat acgaccatta ccacaaccat caagaaccag 121380 acattgttta ccgcaggtat taacctggat atttgtccaa gtccaatcag tagtagcaca 121440 acggacaccc acctgattga tgtggttgac taaaagagaa tctgtagtaa cactaaagtt 121500 accactatca atatttaacc catattcatc aaaacctgct atatggacct tagaaataca 121560 caagtcgcgt cttgggtctg cggtagtgtg gaacggataa tcggctgaga gacctgaagg 121620 agtttctaca tagatacctg ttgtgcccgc agtaaatgac gtgccttgtt gtgcacctgt 121680 gccatatacc ccaaaggcgt ctaatacaat aagggagcat gtatctttta tggtaataca 121740 attcccagta gcagaaggca actgatgcaa ccttgagtaa tgtaatccag acccataaat 121800 agacgacgta ttatatttta actggatatt gctaacgtaa tgtacaccag ttaattgtgt 121860 ggccttacca ctatccacac aagattgtac tggaatagta tcatcattag aaccacccaa 121920 agcaccaaac atgaatgggt taactctatc agcattaaca cgtaaccatg ctgcgccgcc 121980 aacagttttg atcacagtac cgttattatc agtctttcct gtaccatcaa ttaacgcacg 122040 gaatacccct ccaccaagaa gagtacccgc agtgtgttgc ttaagaataa tgcgttgtcc 122100 atccatagtg ggttcagtat tcctgagatc agcaacagaa tggcattctc caatatactt 122160 ggcaccatca ttgcgcccca gagtgtttat cacattaata aatgaatctt ctaaaggcaa 122220 caaatcaacc tgcacatcac ctgggttgta attcaatttc ccagcagata cagaagaaat 122280 gacagaacca tcaggaatgg ttggtaaacc ataactggtt tgcgtcgcta tatcataaac 122340 aactttcttc ccatccaaca aagatatggt gtccgtacta acgatgactt cagagtcttt 122400 tacattagca gaacgggcga tttcttgaat acttcggtca aacgccggac tgatattcgg 122460 ttgtttaaca gacatttcag cgactaccca aacgcctgca gtcagtgcag tttgcaaaga 122520 cactttccct gtcgtgctgt tataggaata ttcaatttcg ggtgttttgt actcgccacc 122580 gatataaaga gattggacac cataggatgt gaaatcagga gtgaactcgg tttcaccccc 122640 tacggcttga aatttgtata tgcggatacc tttggctgta tcttctggcg aaagaatttt 122700 atcgaataag caatacacaa catcgccttt ggacaatgcg cgcccgagat tcaacgtatt 122760 tccttcgatt tcaaagttgt ctaacggaac ttgcatacca ccgttgattg tgactacgcc 122820 agtgacagga tagaacggca aggaaaggaa agtttctcca ccgacatttg atttatacgt 122880 gaaaggaatc tggtggggag ctgtgatcac gccgccgaat aattcttcta catttctggt 122940 catttgaaaa taccccataa ggatttgcca atatggggta tttagtctga actaataaaa 123000 tttatgaaca aaggtataat aagaaccccg ccaaagcggg gtttttgctc aagataaatt 123060 aaagtgtgta tgttacataa cttccatctg gttttttagc aagcaacctc aatgctccgt 123120 cacttccgaa gaagaatcct atagatgaat tatgttccag agcgctctct ggtaattgta 123180 aaggggcagc aggtatactc atatgcttaa agcctaagcg gttaagctga aactcaccta 123240 cacgtacacc ctcctgaatt gccgaaagct tgacaatact tgcctcaccc cctggtgtag 123300 caacctggca atctgccgtc ataagcaaag atgggtttgt agtaccaccc atagcaggtt 123360 gcattgcaag tgtcatttgg ttggcactat gctgaacatt gatattacct ccctgaatat 123420 cgcttatata ggtacatagt aatttcttag taccggaacc agcacaggaa acattactta 123480 cttctgaaga cggagcgtat atagcgtaac cttgtgtagt atatgcatgg atgttaatac 123540 cacgaagtct actacctccc tcacaggtaa tctgatttag gttagttaaa tccttattcg 123600 cacctactac agtaatgtta gtaatatcat tgttggtacc cctatcgaag acgccttcct 123660 tatgggcctc ataagtaaca acattatcaa taatattttt ctgaccatcc caccaagcac 123720 caatccccat acaatcacga gtaataatat tacggatgat atgttgagta ggtaggtgga 123780 accatggata ctctgcgagt gagtagtcat ccacacgttc agttggcgac cctgtgtcag 123840 cattaacatc aataccatca tagtaacact ggattgtagt tatattgtcg aacactaaac 123900 ggtagttcct ggctgaacga cctccaattt cgttctgata ggttttagta cctgattctc 123960 caacacggta tgagattaaa tcccttactc caccatcatg gtctgtacca ccatcattgc 124020 gaatgaacag tacagcggaa ccagagccat attttatctc acccccaaca acccagttgc 124080 cagtacccca tgcagttgta tgatggttct caaatgtaat gcccgattcc aaggcaataa 124140 aattgcgtgg attcttaaca agaatcctat tacataaagt aaatagataa ccaccaaatg 124200 tagcttctgg gttctctacg atgatattat cgccgctcat tattcgcaaa gtagcaccag 124260 caacctgatt ttttacatta tcaggaaggt cgtcccaaat atctaaatcg ttaatatttg 124320 gcttatatcc aacatccaaa cgctgctgaa cagatgccag aacttgtgtt gggtctgtaa 124380 cccaattacc gtttgcatcg aatcggtaaa cagtatacgg cgtagtttta gtatgcatgt 124440 gcggtttctt aattactgaa cccgcaccca aaccattcca aaccaacata ccatcgccaa 124500 tgaattttcc tttgcattca atgattaaaa ctttaccgct aaaatctaca ctctcatctg 124560 cagtaaaagt gtagtcaaca tcaataagca atccatctac ggctgctgtc gctgcatcct 124620 gtaatgtaga ataatcagat aactttactg aatatttgaa ttttttgttg gcttcctgtc 124680 taaattctgc gtcaccaaca ctcaaccatg cacctaaacc aacgccacca gatgtttcag 124740 gtgttgagcc agcatcgaca gttttaggaa gtgaaccatc ccatcgatat tttttatcat 124800 cgtgaacaag aagttcattt ttcacattaa tggtatgacc gaaattaaaa gaaccaggta 124860 aagtcacata ttcttcgcgg cttactgcta attccccaag gtcaacagag ccagaagaat 124920 gagtaaggat ggcttgttcg ttcagactta tcgcaatcgt tcctgaaaca atacctgaag 124980 gaagagaata agcccgttgg gtagactcat cataaattac tttaaacccg ccgagattga 125040 taccagaaga gaaataaacg acttcgtctt ctttgacacc gaaatttcga gcgatagatt 125100 gtttgttaac ttctatagaa gtggagccgc gtggttgatt gaattgagaa atcatgataa 125160 taccccataa aggatgacca atatggggta tttagtctga actaataaaa tttatgaatc 125220 atgggttctt gttatcaaat tgtcaatgtg ttgactaagg ttaattttcc gcctggtcgc 125280 ttatacatgt aactgtaatt tgtatttgca ggaattatta tattgctact aggatagtta 125340 agattaagaa tagaaatatc aactgcaaat tcatcccctg catacacagc gtaagcatcc 125400 gcttgcgaag cattgaaagc acatgagcta ccaatacagc accttgttcc agcaccagat 125460 gaacgtatag cagctttatt ctctatacct gaatcagagt tcgtactcca cccatcgaat 125520 tcaacggcat caatagctaa cctagaccct gatgataaaa ctattgggtt attattaata 125580 cctcttacac ttccggcaga aaaagccatt ccggtagaat ctgtcgcatt taagaaatta 125640 tatgtgcgac tgcttgcaga actgtactcg cctcgtccaa gaacatcaaa agatgacatc 125700 acaaaaccat caactttatc ggttcgtatc atcaccatgt ttgtattgag agtcaagtca 125760 gcatgcacaa aatgtgcatt tgaaatctga acaccagata cgcgacgaat tgagttacct 125820 tgtagttcta atacaggaat agcagtgcct gattcgtttg tactttcacc tatatagaga 125880 ttgctcatgg cagtgttgat atggttagta ctgtcgttct ttggcatcaa acgtattgcg 125940 ccaacatcat acccaccatt tgcccagata ttagtaattc ggtttccgcc agcagcaatc 126000 catagtggaa cacttcctcc ataacagttt acggtatcca ttacagaatc tgagtatata 126060 cggatacatc cacctgtagc tcttttcgtc agatctgaac tggttgcttc ggtataaacg 126120 tcacgcatta cagtcaaacc ctgatcatcg tagataaccc atgtattgaa atttttacct 126180 gtcagttttt catagtacca accagctcca gactcatgca atattgcatg gttgcaacgc 126240 cattctccgt caaattgaat gtttttaaat tttatagaat cctgtccgtg ctggtttacg 126300 ccagaattaa ataaacaatt ttgattatca tttaacggtt tgatcactgt tgttccggtg 126360 tacgcctgat tggcaccttg cccttcaaac gtgaggcctt gtgtgtattc tggaatatca 126420 cactgagaca ttctaagttc acctttagga aatatgatac ggcgaacacc agcagatata 126480 gccgccataa ttgcaggagt ctgatcagct acatgcacac caccaccgta attttctatg 126540 taatcagaaa caggttcttt tttccagttt gagtcaacgg atggggttgc cggaactatc 126600 gaacctggga caataggtcc tttgtatgag taatattcat cattatactt gaatacctgt 126660 aacgaagaat caaaaggaag tccagaacca aaattgcctg aaggaacaaa aggatgtaga 126720 tttgtttgtt gaacattttt tataaaatca aatgtttctt gtacagtatt cccatttcca 126780 gtttttacaa ttccagcccc atttgtcgaa ttcaaatcag atcttaaaga agcatcacca 126840 acacccaccc acgatccaaa cccaataccc ccagatgttt cgggcgttga tccagcatcg 126900 acagttttag gtaatgcccc atcccaacga tacttaccgt ccgtatgggt gagtaattca 126960 tttttagtat tgatgacagc accagaatca aatgtcccag acaatgtaat atattcttca 127020 cgagatacag ctaatgcgcc cagatcaaca ctaccagcag aatgcacaag cacagccgaa 127080 gaactaaggc tgactgccgt ggttccagtc ggtaactctg gaataaaata tgatctctgt 127140 gttactttat catagataac tttatacccg cttaacacag caccaacact aaaataaacg 127200 acctctgtat ctttaacatt ggttacacga gccacttccc gcaaagtata atcaatttga 127260 ttatagatgt ttggcgttcc attgataatt acaacaactt catcctctgc atccagttct 127320 tgtgcaagag tgattttact ggttaatgga tcgaatgtga accccatatt tttatactgg 127380 cgacttccgt ttatatcaat ggccggaaca tcatcaacaa cgatgtctaa cgtgatttcg 127440 gtttcaccgc caatcgctga acccccatta tagacccagg taatcgtaga agaaccagaa 127500 ccaccgccat tacccaattg aatcggagta tattcaatca cctgaagttc tgtgttggct 127560 ggcaaagaag gactgaaagt gattacattc ccatctaatg aatatttgga ttccgcaaga 127620 cgttttccgt cagcatacac gtccacgatt gttggtggag tattgagagt gacagcactt 127680 gtttcagacg ccaaaatttg tgtaaagatt tcacgactgt agacacggcc ttgaccaaga 127740 ccgacgccgg atgtgataac ccaaccttgt tcaggtccag accaagtaaa cgttgctgat 127800 acgttatcag ttgttatagc catgtcttca gtggagccat acaaattatt tccagaagga 127860 gacacggtca atgggtaagt ggcaaatttc ccataagcat cacaaatagt aacggaatcc 127920 ccaatacgcg taggggaagg gagaaccact gtagatgtcc ctgtggtatt attaatgaga 127980 tagccacgac cttctaacaa attgctagag ggagcgtgag ggagcgtttc ccagcgtatt 128040 ccaccgcccc ccaaagacaa ccaaccaccg ttttcgtaat aaccttcaaa ttcatcacta 128100 tcaggattgt aacgcacaga agatggaaga cctgtaactt cagtatcttc aggaaatgtc 128160 attacggcac caggggaatg ctcaatagtg ccggagttgt tgaagccttt tatgttcgaa 128220 gactcagaag tttctaaacc caaagggaaa agaggctgtg ttggtttgtt ggccatttgt 128280 aataccccta aatgtattca tgtcatctag gggtatttag ttttagaaag aagctgcaat 128340 agaataatca acagaacaag cagttgttgt attcgcatta acaacggaaa ttctcaattt 128400 accgcccacc acagaccctg tgaacgtcac tgtaccactc gtacttttct gaactaacaa 128460 ctctgatttg atcgttccgt cacgagttat ggttactcga tatgtgtcaa caacgttacc 128520 cgtcccccat tgcgcagtta ccagtatttg acaaaggttc accaaatcaa aatcgggaag 128580 agccgtcgtt ccagaagccg aaaccgtgta tgacgacaaa ttcgtttttg tgcgataaac 128640 tgcgttccct aaactgttat caattgtggt cattttggca ttatacgttg atacatcgac 128700 cttaccagtc gtgagagaac tgatactgcc gtccaaggaa gtcatcttcg tgttgtacgt 128760 gctgacctcg actttattac ccagagacgt attgatattg gagatactca aatccaatga 128820 cgccatctta gtgttgtaag tcgaggtgtt gactttcccg ttcaacgacg tgttgatgtt 128880 attaatctgg gactctaaac tcagcatatc tgcgtcatac gctgtcgttg tcacatatcc 128940 attaaatcgg ttgtctgcaa acaacgcatc aaaaaatgca gtcattgtcc aataacgcgc 129000 tccagaatct gtttgtactg gaactgaagt cggcaacgtt ggtccggtat acgcagacaa 129060 cctggtgaag tccaaattga atttgtaata tccggatgtc aacaactccc cagccaaacc 129120 agaaccaggc ggggtagtgt cttcactgac gccatgcttt ctcaacatgc tcaggttaac 129180 accatctgtc gagttcgttg gttcatctgt gattgaaacg gattttccgg cgggaacttg 129240 tatgccccca ttggtcacca acaacgcatt gaaagtcttt ttgccattga ttgtttgttc 129300 accactatct gtccgaataa ctttgttggc cagagtatca ttgattgtgt caacagatct 129360 tttcaactcg tatgtcaggc gagcagatgg tggaaacaat gggtcgttaa cttcaaaatc 129420 gttaataacg tcatttttac ttactttgtc atcaacagaa cccaatatct gatctatctg 129480 ctgacctgta tattgactca ggaaatcggc catttttagc tccttgtgct ttctaggaat 129540 acagtaaatc cagcaggatg gaaatgctga cggaagacgc gctcaaacac accttcaaaa 129600 tcagatacgt cgcctgggac tcctataaca taagtgtatt catcataata gtaatcatca 129660 cgcatccctg tcgtgccgtc acattcaaaa tttccgtcca gaccacctat gtcttctttc 129720 gtaaaataga cgctgactgg acaaccaaaa tatatccaaa agaacaattc aattgctttc 129780 ttggttccgc ggattttata gatatgtttt aacagtttca accaacgtgg atgatctagc 129840 gttctccgtt tcgttccttc gatataaaca gagaacgtat cgcccgtggc cgtcaataaa 129900 gaatccgaac cgactgggat aaaatgtcca aattcttgaa atgatttatc aacagttcgt 129960 tggaaaccaa aatcattata ccagtcatct atctgtttgt tcttatcttc tattgacaat 130020 agcggccttc cgtcggcatc taaaagttct tcggcatcca gagccatcat gttctcaaag 130080 gtacgaacca agaatttatc agacaaataa tccttggcct ctgagcctgg agtcttgtca 130140 gcctttaaat caatcagctg tttaaccgga gaatcttcac tctcgggatt catccaacta 130200 gacgtatctg ccagatatgc caagatctct tcttgagtga acccctgctg tctatacaac 130260 caattgaaga acgtgtccat aaattctatg aacagaggga aatcattctg gtagaacaac 130320 ggagtttcat acttaacccc gttgtgtcca ttattaagat ctttggacat agcgcacctc 130380 tggcgtaaca accacatcac caatcttgaa tacttggttt tgtgtagcct gtatgttctg 130440 gttcagtcca tccggtaaca cgactatggt caccccttca gggttatagt tagagaccgt 130500 gatctgctga aggtctacaa ccccatttgc ataatctaca acccctgttt tttgaactaa 130560 aaactctttt gtcgtgtcat tgttattcac tttatacatg ttcagatcgc cattatcgtc 130620 gcgcatgtag taagtgaaat ccacctcggc aggaagcggt ttgaaccccg ttattttcac 130680 agaaccaggt ttgatacttc gtccataact gaatgtgaaa ctgtctaaga caccataatc 130740 aggtttgaaa tggcgtttat aaccaactga agtaatattc gagttgatag aacgttccat 130800 ttttgtaatt gcttcctgca atatttcttt gtcaaacaat tggtcaaatc cgccgagatt 130860 attttcaccc catttaacga tactgtttcc aacaacaact ttcatctgtt cttcaacgta 130920 gactgtagaa gtaggatccc aaaatatagt cgttgagact tggatatatg tgatctcgga 130980 gtctaccact ttgggggtaa tagatcccac attatacttg tccagagcag caacgatatc 131040 ggccttctca gcgtccgaaa gtgtctcacc aacagaaggt ataacagcga tgtaaacata 131100 gccagaatca ggaggagaca gcgtgtcacc accatatgat ttagctcggg agacgttgga 131160 gaataacctt tcagtcaata caccataatc tgtttctgta accgccgcac catcagcctg 131220 ataagctaaa ggagccaacc gtttagtgtc ctcaatagat tctggatcgt ctccacctgc 131280 gctacgttcg gaaaccaatt ctacgtcgac ctggttaaac ccgcctatgg atgacgctga 131340 tgacaggctt gtgatatcat tcccatcagc accagaagtt tccaagtatt gaaggaatat 131400 gacgttccca tcttctactc gacgcgaaag ataaccatcc ccgaattcaa acacatacag 131460 accgtcaata cccaattcta cgaaatacag gtaagcatat tggctcagat caaatggact 131520 gttgtaacgt tgatatgtcg tcgaaacgtc ggaagactct gattcttgta cttgcacgac 131580 catatgattg atatcgacat tcccagaagg aatcgtatat gttgaaatcg cgcttccttc 131640 aacatcatat gtcttgtaca accaattccc ctgtaccaac tttacattgt tgaacatgta 131700 ataaccgtct gcagtcaacg ttgccgacac tggtttctca acagtaaagt tgtaggaact 131760 gccgtctttt gccccaacga acattacgcg ccgatccatg atgatctcat tgggggctgt 131820 gctggcgtca taaggcgtaa ctttgatgtt gacatacatg tatgctgccc gatagttgtc 131880 aggcgtgtag gaaagaaatg cagcagataa accgacgttt gaacgttgat ttgctgtctt 131940 caaatggcct tcaccattaa gcatgttttg cataaaggct atggcgttcg cgtcagatgc 132000 caacaaacga ataatcgcac taagaccaga accttcaaag tcataatctt taaaggtggg 132060 atcagctttc attcgctgtt taataatgta ttcaaatgct ctgacgtcga gtgaaggaac 132120 tgtttgcgtg gccatgataa tctccatcac ctgagtttga atatggtgtt gaagatattt 132180 agccaacggg aatcaaaacg ctcgcgcgcg tttaatttat tcgaatatac tcgcgagggg 132240 gctgacgccc tcgctcgtaa caccgccttg acaggcagtc ccattccgca gccatggagg 132300 ctgcttctcg ttgttcgtta acactcacaa ctcgaagggc accgcgttaa gatacagttt 132360 cttgatgttg tagaaaagta gtttttacct attaataatc actgtcatta ttttattggc 132420 cattcctgtg tttatattca ataaacgtat ctccaatata ataatggaga catttaatca 132480 attcggtgag gctccggaat gcacattaac acagcaatca tgaaacacat tattccttta 132540 ttggcaaaat acgaagggga acgcgccacg aaaatccctt ttggaacaat cacagatgaa 132600 gtgaaacgcc tgacaggtaa aagtatcaat ttccgtcgcg ttgttgaatc tgcgttagag 132660 ttggcccgtt ccgatttaca gaatccaaca ttttcattta atattgacgt aacttcttca 132720 ctccgacaag aattggaaga atcatcacaa gcgcggcgcg atcgtttccg tcatttatat 132780 gttcgtaacg aattctccga aggtcgtgtt ggtatgaaac tggagtctat tcgttctgat 132840 atttgcttca ctgtcaacta tgttttagag ccagaaagcc agcgcattta ttttggcgcg 132900 attatcggtt tctatgggaa ctctattaat ggttgggcag aacgtgttgg attaaaagaa 132960 acccagaaca atcattccac accttctacc cattatatga cgcatgaagc tgctggcgaa 133020 tatgtttacc ttctgcgtcg tgttgtgaag ttagaagtgt taaaataacg ctttattcaa 133080 taaataattg tagtaaagtt agttgcatgg aagggaggga acactatgtt ttacatgatg 133140 ttactcctca tcctcctgat cgggattacc tgctctctcc tgggtctacc cgatcagtcc 133200 ggtaaacagt tgcccacttc ggcgcatccg gttttgagtg aaggttcgtc cgcactgctg 133260 tgggcagtgt agctcaaagg ggagaggact tttcaaatta gctgggctgc ggtaaagtat 133320 taaacatgag ggaaataaca cagtgggagt cgggtttgca gcccaaaacc agttaacccc 133380 tagtctcagg ggcttgtgtg aatagaggcg taatagccac ctcgctggtg tcagtggacg 133440 cacttgaccg tcggagaacg aaactccctg ttgtagcgtg attagctcag aatcagagag 133500 caccctgttg gcaagtcgac accaacatat aaggggaggt cgggggcgct aatctccatc 133560 acgccgacaa cattatgagt cttcatagag ggttcataat gttgcgtcaa agggcaacac 133620 gaggattcct gttggttgga ttaacttgat tcatagttcc tgctgattct tcccggattc 133680 agaagagcac cgacaggacg aggccggatg cgaaagtttc ggtagattat gttgcggtgt 133740 acacacagac tggtgtgtga acataggcag acgaggatag gcgtcccgtg cgacgcttgc 133800 tgatgatggt cgggtgagca ccttctccta agactctgcg ctcaatcagc tgtcggttcg 133860 aatccgacca ccgcaaaata atttaggggt ttgtcaataa cgggtaacag agtatagtta 133920 acccactgaa aacgaaaagc tgtttgggtt ccagacattc acttcggtgg aatccaagac 133980 aaggcgtttg gtgcccaaac aggttttcgt tctcgttgct tgcgactttg cgggttttta 134040 gaaactgacc acaaagataa atgcaaacga taacacgttc ctggcagtag cttaacagcc 134100 atacaccagt gaggtcttcc gattcctcat caccaaattc ggcgcactaa aaatagacgg 134160 gagggtgtga ttaataatct cccgtcgaca atgccgttat atctgactgt ccaaagggga 134220 taagctcctg agtaagcaga ggtgggttgc ctaagtcaga tgggatgtaa ggtcagcgct 134280 ggccaagcat ttgggttcga ctccctaaaa cggctccata tctttgaggg cattccgcgt 134340 cagacgcgag actgtatgga gtttcaggag aaaggcaact taaatccgag gcagtaatgc 134400 cctatgaaat atcggagcct gttgtacact gagtgccctc aaagatgtgt ctcacagcgc 134460 atcagtttgc agttatgcaa gcttcaataa gttaaaacgc gcctcgggcg ttatgggata 134520 aagccttaaa cagtggaatc cccagggcta gcaatccctg tcaaagaagt agccgtgtgg 134580 gggtttgccc ccacaacgca aatcgaagtt ctttgggtat atcttttaac cctcaaggtc 134640 tgtacacaga agtggccgtc ccatgagtaa gttaggcgat atacaacatg ttgggtcgaa 134700 cctgttaagc ccagagaact tcgatttgcg tacttgagag agcgttgtat gaaatagggc 134760 aatgccttgc agacctcgac gcctacacat tctagacact ggtgggcgct ggcgaagatc 134820 tcaatataag ctggtcatca agggtagctc cctgaccgga tgaacaatga gaggccgaac 134880 taaggggaaa cccgagacag gcgcagtatt ctcgagttcg caaaacagtg atcatctgac 134940 aagtgtgatc actcttcgat agagacatta catcgtggct atcaaccaca tcctcgctct 135000 agtgttgagt ggtgttttgt ttcttcggcc agcctcgttt ggtccgagcg atagaggaca 135060 agtattcggt gtgacgaaga cattgaatgc gagttgtgac atttggttgc aactttgatg 135120 gctctggatt ttataaacca tgtctatggg tgacgcggga tctttagtac cagagccatc 135180 aaagttgtgt ccaacccgat cttgcaagcc cgtatccctg tatggttaag acttgcaagt 135240 ggaaagccct ggaaaaataa acgcctgtgg tgaggctacg gtgcaagcca aagacccaca 135300 gaagcgcgtt gccgtgaggc gcacaaacag gcatgcatga actgatcatg cacaaacggg 135360 ataaagggtt gagagacctt ggttggtcac acaataaatt atggggcgat agtttaaggg 135420 attcgatgtg cgcacatcga atcctcatag agaacagctg gaggccaatc cagcaggtga 135480 ggtgaaaagc ctcagacccc gccaaatttt ggccccgtag ctcagtggtt agagcagtcg 135540 actcataatc gattggtcgc tggttcaagt ccagccaggg tcaccactaa ataaaccagt 135600 tgttcaataa acaattggtg agtatgatga aaacgttcgg tgagtttctt actgagtggg 135660 atggcctcgc tactgacaac aaagagattg ttgagtttgt tgaaaagcga ggcgataagt 135720 gggttgtcct tgaccacacc aagactaaag ttcttgggac acatgacacc aaagctgacg 135780 cggacgccca attaagggcg atcgaagcga ataaacatag ttgaagggtt ctatattatg 135840 aagaatattt gggtggtgat ttccaacaga attcgcgcta gttgggaagg tcggatggtg 135900 agcatcaaga acgggtctca tccaaaaact tacgatcgtt atgatcctgc cctgggtctt 135960 catgcagaat aaagttttat cgcgaatcaa cgttacctga ttttacgaat atcgttttgt 136020 atcatgggtc taatgttgaa ttcgatatct ttgattttga aaaatttggc cagactgact 136080 ctggtacgat gggtgctggg ttttacctga cgggggatcc agaaaaggca cagatctacg 136140 cagaaaatgc cgtgcgctat cgtcaatctg gtgaacctat tgtcatggca tttcgtgtca 136200 aggccaagaa gactcttgta atagattcca acaatgtttc ggtgtgggaa aataaaatgc 136260 gagagttggg gataaagcct ggtaagatac atgataatgt gaaagaactt atcaacaaag 136320 ggttcgattc tatagcctct atgagtgcca ataacgttga ggaaatggtg gtgtttaagc 136380 cagggctggc gaccagagaa gcctaaatag tccaaagcgg tttattcaag aggacattac 136440 catgccaatt tcgaaattat ttgaagcgga ttccccagca gatatgccta tctggactgg 136500 tgttcaagac gggacaacga ttgaattctt tgagcgcggg gaaacaggcg ctgaagagat 136560 ttatgcttcc gtacaaggga cagacgtcgt ccgcgccgcc gtagctcttg ctacattttt 136620 agaggacgcc ccgattgacg gtatcccgtt tgaagcccat gtggacccag aagacccgac 136680 gtctatcatc attacagtcc agggttctga atatacatct tacagtattg agcacgatga 136740 agaaacagga gcgctgttta tagccacgga tcttcaattg gaagatgacg aaattgaata 136800 tctgaaacag aatggtcgtc ttccagagta ctctgacgaa gaattggatt cagcgtttga 136860 caacgtagac gatgaagacg acttttggga tgggaaataa acaaaggggc ttaagcccct 136920 ttgttttaga tatcgtttgt gtgtactgtg aatctcattg ttacgacatc tgttctttca 136980 tccttgtgta attcgaactt caaaccttcc ttcagaagac tcgccgccaa caatgttttg 137040 aacttttcga cttgcttgtc tgttgggtat ttttgagact tatatgcctg ttgaaatgct 137100 gttaatattt cgtcaaacct gttgccacca acagcgtaca ccatgtcatc aatttcaact 137160 ccgcgatttg cttgggaaac gagttgcttc ttcattttgc aaacaaagat atcaacggct 137220 ttttcaacta tccccatggc ttcccaaatc tgagcctggt caatcgtagt ctgtaattct 137280 tgtgcgaagt ttttcatcat ttcaccttcc tcgttggata ttggttaaag agtttgccca 137340 gcttggacac attgataatc gtctgagtct tccagcgctc gatcccctct ggtgtagtca 137400 cggttaggat tgaataaccc catatatggg aaccattcag cacagccgcg ctgtgcccac 137460 caattttgtc ttctagttta caaatgaaag actcatattg catcgcagcg tttcgacgtg 137520 cttctttgac aaacagagca tggcgctcag gatcagcttt gacaatatcc ggcttcccag 137580 gtatgtaaga aggattcact gcctgggtca aagaacggta gagcgcatgt tttgatttca 137640 ttctttggta atctggatca ccaaacttga caccaaccga agatggccac ggagcgcact 137700 tctcgacgtc ccagccgttg gatgccagat cgtccattat gttcttgatg actttgttcg 137760 cgtactgctc agcagcattc tcagcatcaa ccagcagagg ctcaactgcg atacggacag 137820 gagtttttgg catattcatg atatagtcct tcagttcaaa gtaagccccc gaaggggctt 137880 tgtcatatta gaggcgggaa tccaaccatg cgttcttttc attctgccat tcccaagcgg 137940 cctgaccacc agccataatc acttccagag aaggagtatt gtcatcctcg ccgccgtgaa 138000 gatctggatc aaatccatca tcttccggat catcttcaca ttcgttctga tatgcggaat 138060 attcaatata atgcgcttcg gcttcgcaat ccatgtctcc cagagcagtc tcaagagtca 138120 ttttaccttc ggcaatcagc tcagccgttg cgtcgtccag acctgcgtct ttcgcttcaa 138180 caaagagttc atgacgtttc tggaagagaa agaattgcat ggcggcagaa cgtgaatcaa 138240 agaattcttg acgaggagcg gtgatatcac gcccatcaat tttacttacc atcacgacac 138300 gagaaccgta ctcaaccagg aagcgaccgc cttttacggg gttgctgccg tcaactgtgc 138360 ccaaagtggt gattacacgg ccttcttcgg tgccgaacaa tacagttttg ccggatttag 138420 attgaacgat aatttcgatt gccatgatgt atttccttct cttcaaattg ttgtttgttc 138480 gtactacaat tagaagtata cgccagttat tgaagaagta aactttattc aataaatatt 138540 ttaataaatt ttgaactctg ctcctttgta cactgctgtc cctcgttcta tgaggccgtc 138600 ggggacaacc acctttgtgg gccatccacc gtccggtgcc ttgacagtca ggcgtgtctt 138660 atgatcaccc agctgaatct gttcgtaaat ccttcctctt actatcgtcg ccccgccttg 138720 ggtgacgagc aatctcttgt ttaccacttt cattccttaa caccaaaaga aaggggagtt 138780 tcctcccctc taacttattt cttcagatca ggccacgcac cagaggtcgc agtagaccca 138840 gctgggggag cagactcaag atcgggagaa cccgactgag taacaacagt gggatctttg 138900 ttaaccactt tgaccccaaa ctgcttgaga gcatccacag cttgcgcctt ccggctgttg 138960 cttttgtaat ggttataccc cttgataccg aatgatgcac taattgctgt caataacgaa 139020 taggtatacc attcaggtgc ggtatcgagc gcctggaggc cgccgattac tgctttgatg 139080 aaatcccctt tatgatactc atcagggaac agaattagtt ccacaaccgg agcagtcatg 139140 acgaggatag cgggtacggc caacacgata gtccagaatt cgtctttcca agacccgccg 139200 acttcggtga tcttagacag ctcccaatct gaggaggact tgatagcctc tagcttgaca 139260 tcgtgttttg cctgaacaac ttcccgcttg tattggatca aatcagtccc gaggttccag 139320 agttgcttta gcgcccctgg gataatactc acaaagggga ttgccataat aaactccttg 139380 gtcattgaac gttcctcagc taaattacgg ggacgtgcta acggcacggt taaccggaga 139440 caaacaatga ctgttttcta tacgaacgtt gcccgacagg gtaacgacct tctgattcgt 139500 attgcagacg acaacggcaa tcgccgtatg ttgcgtaaga aattcgaacc caccttgtat 139560 ttacccacag ccgattattc caaagttgaa aagattggcc tcctcaatga accgttggtg 139620 tctaaaaaat ttgcgtcaat gcgtgacgcc gacaactatc tggaggaata taaggaggtc 139680 gaaggcgctg ccgtttacgg acaaacggat tatgcatatc aattcatagc gcatagtttt 139740 cctgggatga ttacccccga ttactcaaat attcacatcg ccaacgtgga tatcgaagtt 139800 ttctcggctg ggtggcgcga tggagaaatg actaaaggcc catttcctca cgcgacgatt 139860 gaatcccaca cgtttaaggg gagcgaggcg cgtgttcgcc gattccataa gcaagtgttg 139920 gccaaccatg atttcgttcg agagcacttc ccaggttcct ttatttccaa caacgtgact 139980 gaccagttcc ctatcattga tagtaatggt aagatcacac agaacatgaa tgccgccttc 140040 cctattacgc tcatccagct tcaagacatg aacaccaaca agttctatgt ctggggtatg 140100 ccgtgttcta aggatcgcca taaattcaaa tatgatccaa atgatgaaga gataggtggt 140160 cttgaggttg aatacaaaga atacacgact gaacaagaac ttcttcgcgc tttcttagat 140220 tattggtctg aacgtcaatt tgatggttgg actggctgga acatcgaaac gtttgatagc 140280 ccgtacttgg ttgaacgtat tacgcaggtt ctcggcgaaa cccaggcaga gcgcctcagt 140340 ccttggggca aactcaagaa acgtttcatc aaagaccgta aaggcgacgt gacttcttac 140400 caattcgtgg gttgtcctat gatggactac atgcaagttt acaagaaaca cacgtacaca 140460 acccgcgaaa aatactcact ggattggatc gcttattgtg aactcggtga gaagaagttg 140520 gattatagtg aaagcaagtc attgtatgat ctatatttta atgattattg caaacacacc 140580 cgatatggta tcaaagacgt caaactcgtg tggcgtttag aacaaaagct gcgtttgata 140640 cagctgatgt tcgtattggc gtatcgcacc aaatctaact atgaagacgg tcttgggact 140700 gtagcaccat ggctggcgat gtgttactat cgtctttatg aaaaggggat tgtccctaaa 140760 atacagcgtg tgtatgatgg tccaacggac tttgaaggcg catatgtcat ggaggttgca 140820 ccagggatat atttctgggt attctctgag gacttaaact ccctgtatcc ccacatcata 140880 cagcaataca accttggtcc tgagactatc gtatctgaca agcacacacg tcgcgatatc 140940 attgagtcca tgtgtgagga attaaccaaa gcgatgaatg atatgacaac gcctatgaac 141000 aagcgccgtc atctcaaaaa tcttcacgac aagctgcagc gtgctattga tgaacgcata 141060 caagttgttg atgaattggt cgcgctgggt gaattccatt ttgaaacatt acgtcgatat 141120 aacgtttcgt ttaccccgaa cgttcaattc ttcagtaatg agaagatgtc tttcctttcc 141180 gaaattatgc gaggcatata cgctgaccgt aaaggagaga aagcaactgg cctgaagtat 141240 gagcaatggg ctggttggtg taaggaaatg tctaaaggtg atttccacct tgaatctgcc 141300 atgaagtctc gtttctacga tcctgaatgg tatgaagaac acaagcatat cgaccttgat 141360 cacctgactg aagtcatgca caagtgggaa gatttgggag ttgcccaaga tacgttacaa 141420 caaggtctga agatcttgat gaacgcagga tatggtgcaa tttctaacgt ctggtttaaa 141480 gaatacttca acatcaacat cgctgaagca attaccactt ccggccagct gatcaacaaa 141540 tggaataaac gacacactga tgattatctg aacaaacttt gtggtactac tggtcaggat 141600 tttgttatcg cgggtgatac tgactccaac tacatttgca ttgaacgcct ggtcaagcaa 141660 ttgtggcctg aagaaaagga ccatcacaaa ctcgttgata acattgacca atggatcaaa 141720 gagaattacc agccaaaaac cagtgaatgg gcgcagttgt tgtgtaatac catgaacggg 141780 tttgagcagc gcatggtctg ggaacgtgag gtcatcgcat cgtctgctgt atggcgagcc 141840 aagaagatgt attgcatggc agtatacgat agcgaaggca tcaagtatga gaagccaaag 141900 atcaaattca aaggtttgga agcgcgtaaa tcaaccactc ctgagtggtg tcgtgagcgt 141960 ctggttaaat gttatgagaa agtcctgctc ggtactgagg cagaggttca ggaattaatc 142020 gctggataca aaaaggaata tatggaactc accgtggatg atatcgctca ggcatctggt 142080 gtaagcgata ttgagaagtg gttagacgcg aacgggaatt acatcagcgg tacgcacttc 142140 gctgccaagg cttgtattat gtacaacaag ctgatcgata agcacgaaga tctcggtctt 142200 ccgcctatcg aatccggtga taaggttaaa atcatcaacc tgaaacctgg caatcctgtg 142260 gggaatgatc gcatagcctt ccctgacttc cttcctccag aattgggatt ggataaatgg 142320 gtggattacc acaccacgtt tgaaaagacc tttatagagc caattcagtc tatcttggat 142380 gtggttggtt ggtctcataa acgtcgagtt aacctgttgt ccatgatggg caagaaaggt 142440 tgattcaata aaccaaaggg ggatataatt ccccctgtta tccctttgac aacaggtatt 142500 gttatgaaac ttaaaaaaga tgtccttttt tacaaaatca tgcaggtgtt cgctgtgacg 142560 accatggcgt tttcattgtc agcatgtgca actcttctgg attcggttga cctcgatgcg 142620 ccgacgttca ccaatcagca agcggtgaat aagatggaag acacaatcaa ggcacatgct 142680 gcgttggata acaccactcc tggtccgttg caaactgttt gcaattatga cgattccatc 142740 caggaagatg aaacctatca ctgtaccact tacgtgaagg aatcttctgt ggttctgtat 142800 gcagattgca cagaagagca atgcaccgca actggttatg atcaagtgga gaagtctgat 142860 gaataatcat gttggtctgt atgatgccaa ttctaaaatc ggtggaatgt atcgtatcct 142920 ggtagacgta gacttgactt tggttgatag cctctcccct tgggtggatt ggtttaatat 142980 ttccaattca aaagctgctg cggaaaacat gggttgccat gattatccca atgatttcca 143040 gcgtatcacc aaagagtgct atatggctca tgctggtgat ttggcgatcc tcatgcggga 143100 acgcgcgcat ccggcctggt taacgcgccg tgtattcgtt gctggtcaat ggatggattc 143160 acctacagga cgtgatccta tggattggtg gcgcatgccg gacctgtatg ccaagatgaa 143220 cccgcttcca ggcgcttacg atttcctggt gaatctgaag aagatccttc tcgaagactt 143280 tgaaaatgtt gaattgatcg cagtatctaa gtgtgagcca gaacacgagc gcagcaagcg 143340 ccagtttgtc tatgacaagt tccctggcat cttcaacggg tttgtcagca ccgacgaaaa 143400 gcatcttttg gcaggtgatg ttttaattga tgataacccg aaatacgttg aaccctgtgc 143460 gatgaacaat atttttgtca tctttgttcc tcagggaaat tatgaaaaac tggatctttc 143520 gaactcggaa gatatgcttt atattaaacc agtagaaggc cagaaccact tcgacttcct 143580 gaaccgcaat attgtcgaag tggtgaaccg cctgattggc cattatcaat acgtccattg 143640 aggaggacat cgtgcaagaa caatccaagt ttggggaaac cccagacaag cgttccggtg 143700 atagcgatat ggatggcgtt attatccatg tgaacaactt cattcgtaaa caaaccacac 143760 ccacttccgt tggtgcggcg ctggagttaa agcgtgttct gatagaaaac ggtatggcac 143820 cagatgacga tgaaattttc tataacttcg acgaccagta taaagtgaag tttgtagaaa 143880 acgatcgccc acaggttgct gttttctggt ctccctggtt gggcggtgtg agctggcgta 143940 ttgaggaaga tgcataatgg ctaaaataat tgtagtgaaa ggaacaagtg gcgtgggcaa 144000 gggtacgaga gtagtccagt tcatcgaatg gctccgcact aagctggagc ctactgaact 144060 cacctacacc attggtgaca agacgcgccc attcggcctg aaattcgaag agctgaagtt 144120 aatcttcgtc ggccagtata ctgtgtccaa caaatccggt ctggcttcct ggacttccat 144180 ggatgctatt catgctgcca caggctcggg tgatatcgcc cgtgatctgg tcaaaggctg 144240 gctggctcag ggttacactt tggtgtgcga gggtgaaccc ctcatgctct cggataaatg 144300 gcgtcctgaa tggatgttca agaactatcc gattgaatct ctggcgttgc tttattttgc 144360 atacccagac cgctatcagt atgatgcgcg catccgtggt cgctctggta aggaagcggg 144420 ggactccggc tggtcacgca acgaatctta ctccaaggag tttgagaagt cgaagaccga 144480 aatgctggcg ctgggttggg aagtggtggt caatgattac agcggtcaag acgtgttgta 144540 tcgccaatcg tctacaaaca ctcaagaatt caaaacagga aatgatagcg aattagccat 144600 gatgccgttt gatgcacctt tgtgggtgat tggcaacgct attcatcatc aaatgcgtgg 144660 tgagtttcac gccatgggtc tggacatcaa agatttctac ggattctgtg aaactgaccc 144720 aatgacgcgt gaagtcggtg gggatgatcc tctagcgcat cgagtccctg agaaggcgac 144780 caaatctaaa accaaggcga gcgccaaggg agaggtaaca aagtcctctg tatcccttct 144840 cggcctgttg agtaagggtt agaaatgaaa cagatgtcta aatattttgt gttcgtcgga 144900 ttggtgatgt gtatcacagc tgtgcttgtc ggtgtcatga aatatttggg catcgttgag 144960 ttggattcaa ccgaaatatt gaacgtttac gcgttatatt atttgggggg tgctatctta 145020 ttaacgcctt tcgtctataa cataattcag agtttcaaaa ggaattaaaa tgaaaatcct 145080 cattccacgc aacgttgtcg ctgttgctat tgattaccgt ggtgatgcga agatgattaa 145140 cgctgtccgt tattatccgg aacagaataa aatcgtccca caatttcaac tgaataccaa 145200 tccttcttct aaggatttcg gttcttggcg tcaggtgggt ttggctcgta cccaagtcaa 145260 tgcccagcat tttatttccg aaaagacgaa aaccgccaag caaatttggt tggtgacgaa 145320 tgatcgtcgt ttcctgccta tctggtctct gggacagccc gtagtaagcc ccgaagaaat 145380 tcagctggct cccgaagctg agcctgaagt tgtttctcct gtagaggaag cgaaagatga 145440 aaatcaagca ggttgatttt atcttcatga tgttgatgtt cgttatcttt acggtttcgc 145500 tggtcggcgt catggtcaca gaaggggtgc aacagcgccc attcttggtg atatgtcctg 145560 tatcgatcgc cactttcttc tatctggcgt tccgtgttga actcgggagt aaaatcggat 145620 gatacacatt tctaaaatgc cgcagggata taaagcccct gaaaaatgga aatacccgat 145680 tgatctggca gtagattatc gtaagccaga aaatcgcatg tacctgctca aggcatgggt 145740 ggaggcgcta tcctacactg aagagcataa ccagcaagtc cgtctgatgg attatgccat 145800 agaggttaca gaaggcatca cacagctcga gaagatcgag cgcaagattt ggatggcctt 145860 tttgtggggt tgttgctata atgggattgg accatggaca atttacagtg aatttcctgt 145920 acccccacaa tctccgaaag agtttcagcg attttctgat tggtataacc tgaactttga 145980 tcgtatgcgc ttcgatacag attgtcgtta tcgtaagtcg aagatgattc cgtgcgttca 146040 gtcctatatc gattggttgg gtggtaaaac ccaaatggat tcttttcgtt ggatgttgga 146100 atgcactacc aaggaagacc agttcactga actgtggaat acggcgatgt catggaaata 146160 cttcggtcgc ctgagcgcat ggaacttcct ggaagccctg aacatggtct tcggtaacat 146220 atgggatata gacgtccctg gtttcatgtt gcgtgaccgt gatggtagcg aatccaatcg 146280 taacggcgcg gcgttcttat ccaaccgtga tgattgggtg accaagcacg ggaagaaaaa 146340 gatcaacggt tgtcctatta cagacgaaga atgtgatata ctcgaaaccg accttgagaa 146400 agcgtttcag gaatgcgttg aagagtttgg ccacatcacg tttatcaatc gtctgaactt 146460 tgagacctcc ggtgcttgtt ggctgaagaa attcttccga ctgaagaata cccgttacat 146520 cgggtgggac gccgagcgta catgggacga gatcgattat atggaacgta tttggcctga 146580 atactcctgt acacctctct gggaagcccg ttcactctgg ctaccagata ccctgttatg 146640 tgagaaggct cctgcagggc acgttccagg cgtccagaag tggaagatgc ccgtgttctt 146700 tgagacgggt gttcctctac atatatggca cctgcagcag ggtacgcgtt gggaaccatc 146760 tgaggtttac actaatctga aaatggccgt ccggaagata gaggacaatc cgaagtcgac 146820 cagtgtaaac ctcatgtctt tgttgaagcg ctgatataaa tatcctcacc tataaagtga 146880 ggatattatc atgttacaag atctgttggt gtacgcgctt cctggcgttg ttgtcggctt 146940 cgtagctggc gctctggtct ttcgtaaaca cgcgcaagac ggtgaagtga ttgttcagaa 147000 gggtaaagac atcctggaac aaatcgaagc caaactggac gagctgaaga aaaagtaatc 147060 tgattgcgat tgcgttcttc aataaagggg aatgggttat tattagcccg ttcccctttc 147120 tttttgcaag gattgattta tgacacctca atacaaaata ttggtcacca gccgttgtta 147180 tgcttatgga cagggtgaag caatatcagt acacacagtt gtagttgatt ttgaaaacaa 147240 agaacaagca gatttggcat tctataatat gcggcagagc acagctcctg ccgatattgg 147300 cgttaaacaa gtttacacga aattatactg aggtcctata tcatggcaat gcaacgaatt 147360 gaagacatgt ctgcgctcga tatggaagcg acttttggtg attactttga gtccacccca 147420 aaacaaaaag aacctctggt tggtcgtttg gttgtttctg aagcgttcgc ccagaaggtt 147480 cgcgaaggtc ttcctgcaga atatagttgt ttccgtaatg gcgctcctgt tatcgtcatg 147540 ggagaatcta aatgacacag tccgaataca aacagtacct gtacgatctg ttcatgaaag 147600 aaacagacgg cgcactacat cctaagaaag cgactatcgt taaattgcat tctgaaggtg 147660 atttgtctat agcatatatc cgaaaagaac tagatttgat gggaatcgaa tatgaagacc 147720 atatcacgga tacacgtgct ttaaaaagag caacagcaat cgttcttcac gccgttgcaa 147780 caattatgca tcgccaccat gtttcttttg acgatgcaat aactccacag tatcatgaag 147840 aacgttggga tctgttgttg aaaaatgggg ctaaatctga gcataaaaat caacttcttg 147900 gtatgacgaa ggaacaactc gtggatggtg tgttatgatt taccttctgt ttgcggttcc 147960 tgtaattttg gccatcttgt ttgtaatata tcaccgcaag actcatgagc caaaggagac 148020 tttgatcgcc acggccattg ttatcgtatt gtcctgcctt atccagtcgg gattatatgc 148080 tgctttctcc ctgggtagtt cgggagatgt tgaaattttg aatgggtacg ttactgacaa 148140 gcaacgaaat aaggtgggtt gtgaacattc ttatgaatgt atgtgctatt acacaacatc 148200 ttgctctggt tcaggaaata accgatcttg tacacaaacg cgtcattgca gcacatgcta 148260 tgagcactct tatgacgttg attgggacgt attaacaacc gtcggtgatc tgagcattga 148320 ccgtattgat cgtcagggta ctacaaagcc tccgcgttgg gcacaagtta aaatcgggga 148380 acctgcggca cgtgaacatt catatatgaa ttatgtgctg ggcaacaaag attcattatt 148440 ctctaaatct gaccagcaat tcgctgagaa gttcaaagag catatccctt catatccaag 148500 ggtgtatgat tattaccgag taactcgtgt tctgaatatg tcagggatgg acattcctgt 148560 tgattactgg aatgattatc tgaacaatac tctgaaaacg ttaggtgctt cacgtcaggt 148620 taatatcgtt tgggttgtga cttctggcca gcctgttgaa tattttcagg gacttctata 148680 tgcatggtcc ggcggtaaaa agaacgatgt tattgtagtc accgatattt caaaggatat 148740 gaaaattaat tggggtaagt ctacgtcatt tgccgacggc atgaacaaca tggaactcca 148800 ttctcgtaac ggactttcat tgactgggaa accaatgggc atatccgtgt tccaagaagt 148860 tgcggtcaat atcagtaagg gatacaaccg agttgagatg aaggaaatgg aatatttgaa 148920 atggcgagat cttaaaactt gggaagtgat tatcgtcgtg ctgtttggat gtatcccatt 148980 taccgcagtt ttcatattag gccgcatgca gtacaatggt cgaacttata aacgtttgtt 149040 ttaacaagag gaagtaaaga tgtcacaacg taaaggtatt tcaattggtt ggatcgttgg 149100 gttggcaatt ctagcatttg ctgtaattgg gattggcagt gtggttagct atttcaatga 149160 tttcaaccgc attgaacaac aggtcaaaaa gttcaacaaa gattctgaaa accacctgag 149220 caactacacg ctcaaagttc aggagacggc gcagattcct gacatgtaca aaaacggttt 149280 gaaggaagtg atcaaagata ctttccaagg ccgttatggc gcagacggtt ccaaagcagt 149340 aatgcaatgg attcaggaac agaatattca gtttgattca tctttgtaca aagagattca 149400 ggttgttatc agctcaggtc gggatgaatt ccgcattagc caaactaaaa aattggacgc 149460 atgtgcgatc tatgaaacta aacttggcca gttccctggt tctctgatag caggaatctt 149520 tggatatccg cgtatcgatc ttgacaagac atgtcaggtg gtgagtgaca cccgtaccca 149580 ggccgcattt gactccggtg tccagactcc gattaacttc aaaggctgat cttatgagcg 149640 tgaaactaac cgaatctctg acgctggacc aacagcagtc tctgttggac gaaatagtga 149700 tttctgccat caagcagggc attatcaaag acgacacgtt gttgacgcgc cccgaaatga 149760 tccatcatct ggtggtgtgc ctgggcgaag ccaataatcc tcgcaaaaag attgtaatgt 149820 tcaaagaagg cattatttat cccaatggaa gattcgcttg gttaacccta tcgggaagtc 149880 atccggattt gaaggatgaa cagaaagaaa tcaaaacttc tgttccggta acgccataca 149940 ctgaaggagt tgatttattg tcttggtttg agactatcaa taccatctat gtcatggcac 150000 ctgatggtaa gccagcacag gatctgcgtg gtgggattgt aggttcggaa gactaatagt 150060 tcttcaataa atggggatag ggtattattg ctctatcccc ttttcatggg caagaacatg 150120 acagacaaga caagaaagat agcgattatt ggaggaggaa tcggcgctcg gactatggcc 150180 attatccttc aagaaaagtt gaaaggtgtt gaagtagaat gtatcagtgt agacgatatt 150240 cctaaacgtt gttgtgaacc aggtgaacgc atgataattt gtgatgatct ggtagaaagt 150300 gaacgcaaaa cattggtatc tcaagcggtg gctcagttac ggaaggcaga tatttcgtat 150360 tgtgaagcag aagccgatga cagagacata attgcatcac aacgttatca aaagccgccg 150420 cgcctatatg gagccgccca acataaacgt caggctaaga aatataaaaa tcggagtaaa 150480 cgaaaatgac tactcaaaaa ccgacttatg aggaattggc gggtgtaccc ctggggaacc 150540 tgggcatgct cgtccttccg tcagtcgtcc taaaaaggcc aagacccatg gaaagaacaa 150600 aaagaaacgc cgtaaatgat gtcatccccg aatatcgcct tcacgcatta tcggaaggtg 150660 aacccagatc atcacgatgt catgtgatgt ttcaagaagg taaaatgatg gccgatgaaa 150720 tcctcttcct tcgagcagag gtgatccgtt taagtaacaa taaaccccca aagaaatgag 150780 gatatgtcat gagttctatt gaacagctga tcacaccaca atatgtttac agcaatattg 150840 tagagcacct ccgctctcaa ttgaatgtga agcagttgaa cagctctgaa ttgagtggtt 150900 tggaaataac agaagttgaa gttgcggcct tcggtaatcg ttatcatttt gttgtcaatc 150960 acactcaggt tgaacaagtc acttcgagca ttattgacct cggcgcaacg aagccttccc 151020 gcgcagagcc gaaatctgtg acacgcaata ttgtgggtta tctggaagag acgttagagc 151080 caggtgccac ccacccgata ttcaatttca acgccaccgt tgtaaacgtt cagggaagtt 151140 aatcctgatt aaagcctccg attggaggct tttctattga accacccgcc agtatcataa 151200 ccttacccaa taatgtgttc ttctttgatc tgaacaggaa ttctatact 151249

Claims (9)

  1. 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진, 박테리오파지 SC1(수탁번호 KFCC11709P).
  2. 삭제
  3. 제1항에 있어서, 상기 살모넬라균은 살모넬라 콜레라수이스(Salmonella Choleraesuis), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 플로럼(Salmonella Pullorum)으로 구성된 군으로부터 선택된 1종 이상인, 박테리오파지 SC1.
  4. 제1항의 박테리오파지 SC1을 포함하는, 항생용 조성물.
  5. 제1항의 박테리오파지 SC1을 포함하는, 사료 첨가용 조성물.
  6. 제5항의 사료 첨가용 조성물을 포함하는, 사료.
  7. 제1항의 박테리오파지 SC1을 포함하는, 소독제.
  8. 제1항의 박테리오파지 SC1을 포함하는, 세척제.
  9. 제1항의 박테리오파지 SC1을 인간을 제외한 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법.
KR1020170178613A 2016-12-23 2017-12-22 신규한 살모넬라균 특이 박테리오파지 sc1 및 이를 포함하는 항균 조성물 KR102016919B1 (ko)

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Publication number Priority date Publication date Assignee Title
US20110052544A1 (en) 2009-09-03 2011-03-03 Cj Cheiljedang Corporation Novel bacteriophage and antibacterial composition comprising the same
JP2011514802A (ja) 2008-12-24 2011-05-12 シージェイ チェイルジェダン コーポレイション 新規バクテリオファージおよびこれを含む抗菌組成物
WO2011155727A2 (ko) 2010-06-09 2011-12-15 주식회사 인트론바이오테크놀로지 살모넬라 콜레라수이스 또는 살모넬라 두블린 감염을 방지 및 처치하는 방법
JP2014507128A (ja) 2010-12-21 2014-03-27 シージェイ チェイルジェダン コーポレイション 新規バクテリオファージ及びそれを含む抗菌組成物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011514802A (ja) 2008-12-24 2011-05-12 シージェイ チェイルジェダン コーポレイション 新規バクテリオファージおよびこれを含む抗菌組成物
US20110052544A1 (en) 2009-09-03 2011-03-03 Cj Cheiljedang Corporation Novel bacteriophage and antibacterial composition comprising the same
WO2011155727A2 (ko) 2010-06-09 2011-12-15 주식회사 인트론바이오테크놀로지 살모넬라 콜레라수이스 또는 살모넬라 두블린 감염을 방지 및 처치하는 방법
JP2014507128A (ja) 2010-12-21 2014-03-27 シージェイ チェイルジェダン コーポレイション 新規バクテリオファージ及びそれを含む抗菌組成物

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