KR101993122B1 - 신규한 클렙시엘라 속 세균 특이 박테리오파지 kp1 및 이를 포함하는 항균 조성물 - Google Patents

신규한 클렙시엘라 속 세균 특이 박테리오파지 kp1 및 이를 포함하는 항균 조성물 Download PDF

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KR101993122B1
KR101993122B1 KR1020170169376A KR20170169376A KR101993122B1 KR 101993122 B1 KR101993122 B1 KR 101993122B1 KR 1020170169376 A KR1020170169376 A KR 1020170169376A KR 20170169376 A KR20170169376 A KR 20170169376A KR 101993122 B1 KR101993122 B1 KR 101993122B1
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klebsiella
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김영주
연영은
한범구
김현일
박철세
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Abstract

본 발명은 클렙시엘라(Klebsiella) 속 세균, 특히 ESBL(extended-spectrum beta-lactamase)-클렙시엘라 속 세균에 특이적인 사멸능을 갖는 신규 박테리오파지 KP1, 상기 박테리오파지를 포함하는 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 클렙시엘라에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 KP1을 이용한 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 클렙시엘라 속 세균, 특히 ESBL-클렙시엘라 속 세균에 대한 특이성이 매우 높고, 상기 박테리오파지 KP1은 클렙시엘라 속 세균에 감염하여 탁월한 용균 활성을 나타내고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 KP1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.

Description

신규한 클렙시엘라 속 세균 특이 박테리오파지 KP1 및 이를 포함하는 항균 조성물{Novel Klebsiella genus bacteria specific bacteriophage KP1 and antibacterial composition comprising the same}
본 발명은 클렙시엘라(Klebsiella) 속 세균, 특히 ESBL(extended-spectrum beta-lactamase)-클렙시엘라 속 세균에 특이적인 사멸능을 갖는 신규 박테리오파지 KP1, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 클렙시엘라에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
일반적으로 클렙시엘라(Klebsiella) 속 세균은 장내세균과의 한 속명으로, 그람음성간균이다. 편모는 없고, 협막을 지나다니면서 점액을 생산하는 것이 특징이다. 구연산염으로부터 탄소원을 얻고, 여러가지 탄수화물에서 황화수소를 제외한 산과 가스를 발생시킨다. 자연계에 널리 존재하며, 사람의 호흡기, 장관, 비뇨기에서 검출되며 급성 폐렴의 원인균으로 알려져 있다. 최근에는 다양한 클렙시엘라 속 세균이 진단, 검출되고 있는데, 폐렴간균(Klebsiella pneumoniae), 클렙시엘라 오자에나에(Klebsiella ozaenae), 클렙시엘라 리노스클레로마티스(Klebsiella rhinoscleromatis) 등이 존재한다.
임상적 측면에서 클렙시엘라 속 세균 중 대부분을 차지하는 것으로 알려진 폐렴간균(Klebsiella pneumoniae)은 그람음성 (Gram negative)의 간균, 통성혐기성 또는 호기성 세균으로 사람의 장관 내, 피부, 구강, 호흡기 등에 상재하고 있으며. 폐렴의 10~20%는 이 균에 의한다고 한다. 또한 요로감염증에서 분리되는 경우도 있으며, 패혈증, 복강 내 감염 등의 주 원인균으로 보고되고 있으며, 중환자실 환자에서 발생하는 균혈증의 원인균으로 높은 감염률을 보이고 있다.
한편, 현재 미생물을 효과적으로 사멸시킬 수 있는 다양한 항균제가 사용되고 있는데, 베타락탐 계열의 항생제는 현재 사용되고 있는 항균제의 약 50%이상을 차지하고 있다. 그러나 많은 그람음성 세균에서는 이러한 ß락탐 계열의 항생제에 대해 베타락탐분해효소를 생성함으로써 상기 항생제들에 내성을 나타내는 것으로 보고되고 있다. 현재 발견되는 클렙시엘라 속 세균인 폐렴간균 중에서도 항생제 내성을 나타내는 세균인 ESBL (Extended-spectrum beta-lactamase)-폐렴간균이 35~45%에 이르는 것으로 밝혀져 임상에서의 ESBL-폐렴간균의 사멸의 중요성은 크다고 할 수 있다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
현재까지 클렙시엘라 속 세균, 특히 ESBL-클렙시엘라 속 세균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 클렙시엘라 속 세균, 특히 ESBL-클렙시엘라 속 세균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.
한국공개특허 제10-2015-0123396호
이에 본 발명자들은 클렙시엘라 속 세균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 클렙시엘라 속 세균, 특히 폐렴간균을 선택적으로 사멸할 수 있고, 더 나아가 항생제에 내성을 가지는 ESBL-폐렴간균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 클렙시엘라 속 세균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 KP1을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 KP1을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 KP1을 개체에 투여하는 단계를 포함하는, 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 클렙시엘라 속 세균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 KP1을 제공한다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 세척제를 제공한다.
또한, 본 발명은 상기 박테리오파지 KP1을 개체에 투여하는 단계를 포함하는, 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 KP1을 이용한 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 클렙시엘라 속 세균, 특히 ESBL-클렙시엘라 속 세균에 대한 특이성이 매우 높고, 상기 박테리오파지 KP1은 클렙시엘라 속 세균에 감염하여 탁월한 용균 활성을 나타내고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 KP1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
도 1은 하천에서 채취한 시료 내 박테리오파지 KP1의 존재를 확인한 결과를 나타낸 도이다.
도 2은 박테리오파지 KP1의 클렙시엘라 속 세균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 KP1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 KP1의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 KP1의 pH 안정성을 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 클렙시엘라(Klebsiella) 속 세균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 KP1을 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균, 특히 ESBL-페렴간균에 대해 용균활성이 탁월하다. 상기 박테리오파지 KP1은 200-250nm의 크기로, 정이십면체의 머리를 가지며 수축성 꼬리가 있는 마리오비리데(Myoviridae)에 속한다. 본 발명의 박테리오파지 KP1은 단백질 패턴 분석 결과 70 kDa, 55 kDa, 50 kDa, 35 kDa, 33 kDa 그리고 16 kDa의 단백질을 포함함을 확인하였다. 그 전체 염기서열을 서열번호 1로 표시하였다. 또한 상기 박테리오파지 KP1은 pH에 대한 안정성이 우수한 특성을 가지고 있다.
박테리오파지 KP1은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 KP1은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
상기와 같은 클렙시엘라 속 세균 특이적 용균활성, 내산성 및 내염기성은 본 발명의 박테리오파지 KP1을 클렙시엘라 속 세균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 KP1을 유효 성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 pH 범위의 적용이 가능하게 한다.
본 발명의 박테리오파지 KP1은 상기 박테리오파지가 존재할 것으로 예상되는 하천으로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 이를 박테리오파지 KP1로 명명하고 2016년 7월 22일에 한국미생물보존센터에 수탁번호 KFCC11674P로 기탁하였다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명에서, 상기 클렙시엘라 속 세균은 폐렴간균(Klebsiella pneumoniae), 클렙시엘라 오자에나에(Klebsiella ozaenae) 또는 클렙시엘라 리노스클레로마티스(Klebsiella rhinoscleromatis)을 포함하며, 바람직하게는 폐렴간균이나, 이에 본 발명이 제한되는 것은 아니다. 임상적 측면에서 폐렴간균은 클렙시엘라 속 세균 중 대부분을 차지하는 균으로 폐렴간균은 클렙시엘라 속 세균을 대표하는 세균으로 알려져 있다.
본 발명에서, 상기 클렙시엘라 속 세균은 베타락탐 핵을 분자 구조 내에 포함하는 베탁락탐계 항생제 내성 세균인 ESBL(extended-spectrum beta-lactamase)-클렙시엘라 속 세균일 수 있으며, 바람직하게는 ESBL-폐렴간균일 수 있으나, 이에 본 발명이 제한되는 것은 아니다. 따라서 본 발명은 상기 균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공할 수 있다.
상기 베타락탐계 항생제는 예컨대 메티실린, 디클록사신, 옥사실린, 플루클록사신, 아목시실린, 암피실린, 피페라실린, 티카실린, 아즐로실린, 카르베니실린과 같은 페니실린계, 세팔렉신, 세팔로틴, 세파졸린, 세프테졸, 세파제돈, 세파클러, 세푸록심, 세파맨돌, 세포테탄, 세폭시틴, 세프트리악손, 세프탁심, 세프타지딤, 세파핌, 세프피롬과 같은 세팔로스포린계, 이미페넴, 메로페넴, 에르타페넴, 파로페넴과 같은 카바페넴계, 아즈트레오남과 같은 모노박탐계 항생제를 포함하나 이에 제한되는 것은 아니다.
본 발명에서, 클렙시엘라 속 세균에 의한 감염성 질병은 폐렴, 요로감염, 창상감염, 뇌수막염, 골수염, 상처감염, 내안구염, 안내염, 간농양, 인후염, 설사, 패혈증, 축농증, 비염, 중이염, 균혈증, 심내막염, 담낭염 또는 이하선염을 포함하며, 이는 특히 폐렴간균에 의하여 발생하는 질병이나, 이에 제한되는 것은 아니다.
본 발명의 약학적 조성물은 1 X 103 내지 1 X 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 X 106 내지 1 X 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, PFU(plaque forming unit)는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.
본 발명의 용어 예방이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.
본 발명의 용어 치료란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.
본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.
본 발명에서 용어, 약학적으로 허용 가능한 담체란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.
본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수 도 있다.
상기 비강 분무의 경우 일정량의 박테리오파지 KP1을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.
상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.
본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감음성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마스네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.
본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 동물에게 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 KP1은 기존 항생제에 비하여 클렙시엘라 속 세균에 대한 특이성이 매우 높고, 동시에 베타락탐계 항생제 저항성 균에서도 작용하며, 유익균은 죽이지 않으면서 특정 병원균만 사멸시킬 수 있다. 아울러, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다는 이점이 있다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 사료 첨가용 조성물을 제공한다.
축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 KP1을 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 KP1을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 유지류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 KP1을 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 KP1 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 클렙시엘라 속 세균의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 소독제를 제공한다.
클렙시엘라 속 세균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 KP1을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 KP1을 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균에 특이적 사멸능을 가지므로, 클렙시엘라 속 세균에 노출되었거나 노출될 가능성이 있는 개체의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 KP1을 개체에 투여하는 단계를 포함하는, 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명에서, 용어 "개체"는 클렙시엘라 속 세균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 KP1 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 KP1 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 KP1의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
중복되는 내용은 본 명세서의 복잡성을 고려하여 생락하며, 본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예 1: 신규한 박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 분리
클렙시엘라 속 세균 중 폐렴간균(Klebsiella pneumoniae)에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 하천으로부터 채취하였으며, 박테리오파지 분리에 사용된 폐렴간균은 아시아태평양 감염재단에서 분양받은 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 폐렴간균과 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.2 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다.
전배양된 클렙시엘라 속 세균 150 μL를 취해서 멸균된 튜브에 넣고 3-5 mL의 BHI 탑 아가(top agar) (뇌 심장 침출액(brain heart infusion) (뇌 침출 고체 12.5 g, 소 심장 침출액 고체 5.0 g, 프로테오스 펩톤 10.0 g, 글루코스 2.0 g, 염화나트륨 5.0 g, 인산나트륨 2.5 g/L) + 0.6 % 아가)를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% BHI 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다. 그 결과는 도 1에 나타내었다.
한편, 박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(폐렴간균) 배양액 150 μL에 혼합한 후 0.6% BHI 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8g/L; MgSO47H2O 2g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.45 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.
도 1 및 2에 나타낸 바와 같이, 1-2 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 클렙시엘라 속 세균의 대표 세균인 폐렴간균에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예　1.1에서 확인한 폐렴간균 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0x109 PFU/mL로 희석한 후 전배양된 폐렴간균 1.0x109 CFU/mL과 혼합하여 MOI (Multiplicity of infection)가 0.1이 되도록 하여 35℃에서 120 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 박테리오파지 KP1(Bacteriophage KP1)로 명명하고, 2016년 7월 22일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고 수탁번호 KFCC11674P를 부여받았다.
실시예 2: 박테리오파지 KP1의 전체 유전자 분석
박테리오파지 KP1의 전체 유전자를 분석하기 위해, 박테리오파지 KP1 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL가 되도록 TE 완충액 (Tris-EDTA, pH 8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국).
시퀀싱 결과로 얻은 박테리오파지 KP1의 전체 유전자의 크기는 167,989 bp 이며, GC함량이 40%, 전체 ORFs의 수는 280개임을 확인하였다. 또한 분석한 박테리오파지 KP1의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예 3: 박테리오파지 KP1의 형태학적 특성
박테리오파지 KP1의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 Carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경 (Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 KP1은 200-250 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.
실시예 4: 박테리오파지 KP1의 단백질 패턴 분석
박테리오파지 KP1의 단백질 패턴을 분석하기 위해, 1.0x1010 PFU/mL로 준비된 박테리오파지 KP1 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 KP1은 70 kDa, 55 kDa, 50 kDa, 35 kDa, 33 kDa, 그리고 16 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.
실시예 5: 박테리오파지 KP1의 다양한 세균에 대한 감염성 조사
박테리오파지 KP1의 다양한 세균에 대한 감염성을 조사하였다.
우선, 박테리오파지 KP1의 클렙시엘라 속 세균인 폐렴간균에 대한 용균 활성을 확인하기 위하여, 소프트 아가 오버레이법을 이용하여 아시아태평양 감염연구소에서 분양받은 ESBL(extended-spectrum beta-lactamase)-폐렴간균을 대상으로 용균 활성을 확인하였다. 그 결과를 표 1에 나타내었다.
대상세균명 대상 세균수 용균 활성이
확인된 수		 용균 활성이
확인되지 않은 수		 감수성 비율
ESBL-폐렴간균
(Klebsiella pneumoniae) 		11 균주 9 균주 2 균주 81.8 %
상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 KP1가 ESBL-폐렴간균 11개 중 9개의 균주에 대해서는 용균활성을 나타냄을 통해 본 발명의 박테리오파지 KP1이 ESBL-폐렴간균, 즉 클렙시엘라 속 세균 중에서도 베타락탐계 항생제 내성 세균인 ESBL-클렙시엘라 속 세균에 대하여 탁월한 용균활성을 가짐을 확인하였다.
또한, 박테리오파지 KP1이 다른 속 세균에 대해서도 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.
Figure 112017123130305-pat00001
(+: 용균활성 있음, -; 용균활성 없음)
표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균인 폐렴간균 외 다른 속인 Salmonella 종이나 Escherichia coli, Bacillus cereus , Staphylococcus aureus , Lactobacillus plantarum, Enterococcus faceium 등의 균주에 대해서는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
실시예 6: 박테리오파지 KP1의 pH 안정성 조사
박테리오파지 KP1의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 KP1 배양액을 4.0x109 PFU/mL로 준비한 다음, 상기 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.
도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 KP1은 pH 3-11의 범위에서 안정한 것을 확인하였다. 이를 통해 박테리오파지 KP1은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.
상기 실험으로부터 박테리오파지 KP1은 클렙시엘라 속 세균, 특히 ESBL-클렙시엘라 속 세균에 감염하여 탁월한 용균 활성을 나타내고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 KP1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 KP1은 클렙시엘라 속 세균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 KP1을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예 1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 KP1 1 X 106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으로 제조한다.
1.2 액제의 제조
박테리오파지 KP1 1 X 106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 KP1 1 X 106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
한국미생물보존센터 KFCC11674P 20160722
SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Klebsiella genus bacteria specific bacteriophage KP1 and antibacterial composition comprising the same <130> OTP1.28P-1 <150> KR 10-2016-0176923 <151> 2016-12-22 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 167989 <212> DNA <213> bacteriophage KP1 <400> 1 attaaaaatc gctttttgac tttcttttaa ttggtcaaac gtaatcatgc cacttttacc 60 ctcactacat gcagattttt aatttttgct ttgagttttt cacgctcaac atcgctaagt 120 ggttcataca ccagctcagt tgttttccac caaagcattc ctttggtttt gctttttcca 180 gtaaaattcc cttttgctaa tttgtctgtt aaaaccgaca ttgtacgaat ccgtgcttta 240 ttagccgatt cttcattagt gaagaccaca catcgttctc catcgtacat atcagttgtg 300 actggatggt caaatccgtc tttatcctta tacgctacta catatccata gtgttgcatt 360 acattttacc tctcaaaagt tggaagaagg acgcagtcaa tggaagacct tttttcaatt 420 ttaacttatc tagcattgag catttttcta accgacgaag tgagctaaca attagccgta 480 ttgattgtac acggatttca gcatctgacg gacgattcgg aactgatgct aaaatagcag 540 ataacttacg ctcaacttta gctaattcag acttaccacc gctgatacga gttctcaatg 600 cattaataag ttctaaatct gccgaggttg cagttccatt cttttctttt tgcacaaatt 660 gagaaagatg attttcgcga ttacgtaagt tagttttaat tgatgtgata gttttttcat 720 actcacgaat cttttccaaa cgagaagctt ctttatcact tgttggctta acagaatctg 780 aagaacgaac tatgcgtgct gcgatttcat tcgcttttcg ctcaaggcct tcaatagtgt 840 tatttccacg taaggtatta tacttttgct tgacaggaat aacattccct actacatatc 900 ctaaatcatt attccagcgt tcaagcgtca tgctgtcagg atggtttcct ttgacggttc 960 caaacttttc acctgagtat gcgcaatgag tctgctgcat gatgttaaac agatattctg 1020 gggtgagatt gaactccttg tgccgacgtt gagcagaacc taaagttgta attaaacgag 1080 tataaacttt agcggtttca gcagtaaatt tcatcatgtt ttcctcaaaa atgctttcgt 1140 cttacggacg gtataatggg tctaggtccc tagttctaga taatcactag ttgactaagc 1200 tatagtaaca ctaaagtagt ccataagtaa accagatttt tcaactttgt tatgacccac 1260 cactttgaac ttagttccca tcggtagcat cctttcttgt tctttatcaa tcatctcgat 1320 gtcagcgctt ctgcgctgag caatgttatc aatcacatca tttggtcgca tgaattcaga 1380 atctggtgca gtaattaaaa gcgatttcat gttggtatga taatcaaatg attgatggca 1440 attattgact tcaatgacta caaaggtcga gtaatgccat ttgcctgcaa actctcgggc 1500 gattgtttca tctgtcgtga atgatgccac ctttccaaag tcaaattgct ctcctttaat 1560 aagagcttca taaaaggctt tagcctcacg gcatgataga cctctataga gagtgtctct 1620 gttatcaatt tgatggcgcc taacgataga gtcaagtttc ttatgaaatt cttcgccaat 1680 cttattgttc atgcactgcc acagaattga ctgttctttg cagtcaaaac gattggctaa 1740 tgcttcccac acgcttaaat catataaagg taatcctttg ctttctcgcg cgaagttaag 1800 aacatcaatg gaacgaatgg gttcttcgat aggaataacc tttgataatt ttactgaaat 1860 agatgggttt aatgaaatag ccatgatatt ctccattttg gttacgagag gtatcatatc 1920 atggcttttt agaagagtaa actactttgt gaaattattt tgcccacgga gaccagggcg 1980 gcgggtcaga ccagattgaa gccagttcgt ctagaagagc ttctggggct ttaataccat 2040 acttctgtat aattatacgg tattcgtctt tgatgtcctt agaaatcact ggatgaactt 2100 gaacctcttc ctgaggctct tccatcattt caaacaaatc catcacatga accactcagt 2160 attgcgatac agacaactac tgctgttata tccatcagct gctttttgta acagcgggct 2220 tggaacaagt ttgataaaat ctgcgcccat atataaccaa actaacttag taaattctat 2280 tagagaatct gtactatcaa tgataatctt tttgcctctt gaaattatgt cattttcgta 2340 ttcatataag ctagtttcat gacatacatt ggtgtatcct ttcaagtgga gagcatgcag 2400 tatagaaaca ggacttcctg gaactgtatc tacgtcaaag acatgagcag tcttaataat 2460 gccgtaatct tcagaaggac accaaccaaa tgcctcgaat ttattaacta agtctttgaa 2520 atctttgtcg aacgtactgt atagagcaac agtaaaaatt ctatcttggt caagacgcaa 2580 agctcctttt gcatcatttc ttgattgaac tgcgcgttgt aagcttactt tatagatttt 2640 tgcgtttgcc acacatagct ccttcagtca tgttgttgtc ttcaaaccac ttatcatttg 2700 ctttaattaa agcaggcgca gcttttagta ataacgctgc agctcttaca cctctgtacc 2760 aacaatcaaa atgagacttc tttaatggcg attgatacca gggcttagta taacatatca 2820 ttttcttctc ctcagttagt aggaataata tactattccc agtatagcat aaaaggactc 2880 ccggaggagt ccttaatttt tatacttctg catcagcttc aaacattttc gcattggtgg 2940 ttgcccaagt tgcagcatca tcaactactg ttgaataagc agctttttca gatgggaaaa 3000 tctgatactg tgcgttagca atgcgatgtg aatcagaata caccttaaaa gctacagata 3060 cttctgtacc tttaacttcg ccaccagcag tagtatggtc aaaagttttg atatttacgt 3120 aagccatttt aatctcctat ttagtttaca ggagtattta tatagctgcg gtaagcacct 3180 ttaatatttc tttatcaatt tctcgagtga tttcttctcg aagggccaat actaaggccc 3240 tttctttttg ctttctgata atttttaaac gacgcttaga tattctttta gccattagta 3300 gcctgcatct tgacgagcaa agttctcagc gtttttcaga taatacagtt taaagatttc 3360 ttcagaatcc agaccaagcg ccataaacat attcagaaca aagtgcagga tatcaatcat 3420 ttcaaatttg atttcaagct ggtctttatc agacaggtct ttgatataag tttccttcat 3480 cttgacgtgg tcggctttcc acggtttcca cacagcacta gctgcctttt caccattact 3540 cataccgcca agagatgtca gaagttcgcg gaattcgtca tcaatgtaat ctttttgatt 3600 acgcagccac tgcacgatat caccggcttg agccaattca tcaggatgca tgttagtacc 3660 aggcttgtca tttgcaagac gaacctgaag agatttttgc atatcaagca ttacttgcag 3720 agggtcacca ccaactttgc gtacgatacc tgcgtatcgg gcttcagctt tatctgcacc 3780 agcgatcagt tgactacatt cgttaaagtg tgccattatt ttattccttt caattaaatt 3840 agataaatat tatatcactt aacataaata gcaggaggat tcatgtctga agtgaaacaa 3900 gaatgtaaag acaagggagg atttggaaga tatctttacg tcggaatcgc cactgctgct 3960 ttagctgcat ggaattatgt ggtagttcca ttagctagca cacacgggct agttcttcct 4020 ccaatgccgt tagaaaaagt tgtgtcgttt attatgactg gaggattgct ttaatttaag 4080 gggctttggc ccctatacct tcgcatattt gtcaagacgt aatttagcca ttaaaccttg 4140 cgatatattt tgattaatat aatccgttat ttcagaagca gttgccccct ctttcataat 4200 catatcattt atatctttgc ttttccaagg cgacttatcc cagaaaacta ccttttcacc 4260 agcatctact aaacgtttca tacgcttaat cgtatcagga tgacgaggtt catggtccat 4320 aatccatgct cggttatcat gacatggaac ttgagctaaa tctaaagacc caccggtaat 4380 tgcaatagca ttatcaatga acaacgaatc tattggtcct tccatgacga atacgagttt 4440 tgactcatca atagtgtcga gaccataaat tttggtcgcg tgttcgtggg ctttgattgt 4500 gatgtatttt tgtggagcat tctttcgtag tgctcgtcct tgaaacgact caatctctcc 4560 tttcttgttg aagataggaa taaccaaacg tggttcgttc gtctcattct tataggttcc 4620 tggattaacg gagttaacaa gagaaggcca ttggttagta aaccataacc ttttccaaga 4680 agtgcttgga atacatctgg cagtcacgta tttaactatc ggatgttcct taggaagtct 4740 atctaatcgc tcgcagaaat taagtttttc tattacgggg agttttgcat taattttctc 4800 agacggttct acagtctttg gcttatcaaa gacccgctcc tttcttttct caagaagata 4860 ctctcgatag aggtcaggtt cattatcttt aagatactgc gatagccact tgttatactc 4920 acagttgaag caatgacagc gtaatccttg acctgcatca aaaatccaga atcgggcttt 4980 attgatatct ttctgtgagt caccacaaat tgggcaacga cagtttaact tgaatgttga 5040 agatgtagta acgtgtctaa atttaggtag gtgagatatt gcacgaattg catactcgtt 5100 atcaacccaa gacataatat ttcctctggc cttaaactaa taaggccatt ttatcacttt 5160 ttcttggcag cgtctttatc cgcttttcgt ttctttggaa gggtttcggg tcctttattg 5220 acgatgtccc cggaagtggt acctgatgca atattctgtg gattgccgcc cgcatcacct 5280 gcgaccatct cagtaacaaa ctctttgtat gttttcatag agcctcctac tatttattca 5340 tgcgtaatac gtaagcattt atatgtagga tacagcgtcg gagacattga ttttggattg 5400 tctttgataa gcataaactg cttgcctgta tcttcacact tttgcttaat cacggcttca 5460 tctttgccag tgaatgccat cttttcagta gacattccac ctgaaccagt agatagcgcc 5520 attattaaaa cgtacgtaat catcctaaaa tccacttaac aatgttgaag ttatcaaact 5580 gagcatcaca gtaaagaaca tagttcagct taagtgctgc gccgtcgtct ttaagttctg 5640 cttgcacttc tgattgttta cttgggtcta cgttttccac aatatgacca acatctgcac 5700 gaatttgctg agctacttca gattcatctg cggtcattga ccactcacat aagtctttgt 5760 catagttggc catagcagga actgcagagc aacttgatac tgctaacact aaagcaagta 5820 caatcttttt cattttgctt tcctcttctc aatttgtttc agtaaggcca tagtatcatg 5880 gcctttgaag aaagtaaact accttttgaa caattttttc aacaaaatgt cagaggtcag 5940 attcttggtg ggtagatatg ttgccgagtt gacccagatg ccatcgctgt tatacacctt 6000 gacctctcca tagtcgcata cagataggtc tgctttgtta tatgcctcaa tgcctcgatg 6060 aatggtatct gtggctgtta cgacaaaaga gtgacctgat tggtcacgga ccgcgctaaa 6120 cacaaaaatc ataaaattta cctagaattt taactcttct gccagagcat caagcttaga 6180 acgtgatact cgttcttgac gattagattc ggctacacgg ttctgtgcac ctgcaccttc 6240 tcggacggta ttgcttggat taggcttagt tgggtcgttt tgctgctcaa tttctaccca 6300 acgctgatta gccttatgta cacccataga gaacttattg ttgatgttct tatcaccgta 6360 acgcgattta atctgcttaa ttaattgttg cttcatctga gcaagttcag gggtttcaat 6420 cacagccagc ataaagtctg ccgtagcagg tagacccgca gattctgcaa tatcactcat 6480 gtccatatca gaagcatccc acgctgaacg acctacctga gccgcggtcc aaagaacagt 6540 ttcagattct acagccaatg cgcgaagttc ttctgcgata gctttaacta acgtgtaact 6600 gttttcagta tattgacgaa tacgacaaga agcacaaata ccaagatagt caatgatgat 6660 aacagtcggt ttaaagttct tcttgagttt caattcattt agaagagctc ggaatgtatt 6720 agcgttagca ccgccagtcg gatactgttt aatgattaaa cgaccaagag tactagaact 6780 acgccatttt tccatcttgc ctttatattc agcgtatgat acacagccat catcaatatc 6840 gtcaagtgat acatcaagca aattagcatc gatacgttta gcacaaactt cttcggccat 6900 ttccatggaa atataaagga cattatgccc catctgaaga tagtctgcag ccaatgaaca 6960 caatcctaac gatttaccaa cgttgacgcc agccatcaat acgttcagtg taccagtctc 7020 ggcaccacct ttagtaattt tgttcagaat gctaagttta aacggaactt tacgagcttt 7080 attctggtat gataaccaac gagcttcgta atcttccatc caatcatgac caatatagct 7140 atcaaacgat actgataacg cttcgcgcat gatatcagga atagctccca tatcaggaag 7200 acgcttatct cgcttatttg gctcaagctg ggcattagcc tgaatttcaa taattcgaga 7260 cgtagcgtta tacatagcct tttcttgaac gtacttttca gtttccttaa ctaaccaatt 7320 caaatcttca ggagcatcag ataacttatc aataagtttc tttgcgcctt catgttccgt 7380 ttcagttata gacgaattat ccagtgctac acataaagca gtctttgaag gaattgctgt 7440 atattcatta acgtgcttct taattatgtt aaacaccgtc tgagcaggtc cttgctcgaa 7500 gtactctttg tccatatatg gccaaacctt cgtaaagaaa gcctggttgt aaatcagatt 7560 agctaagatt gtttctacca ctttaacctc ttaaaagatt ttccataatg attttttctt 7620 ggtctttaat gcactctgga tttgttgttt aacacaagct tccacatgag gataaagttc 7680 atccttatga gcttcagatg gagtactaaa ctcaatagtt acttcccccg aaggagaaat 7740 atttaattta tgaacataaa ccaagtgtga ttgaccattt aattttatca caatttcttg 7800 gataacagtc ttcatagctt cttggattat ttcatggctt ttcttgaaca ctcgttcttg 7860 acgctcgaag tctccctctt ccgagggaga ttcttgttca aatttctcga gttcagattc 7920 taaatcaaac tcagtcttca ttcatgaagt tctctaattc atcttcaact tcagcagctg 7980 atactgaacc actctcaggg agtttaacac catcaacctt agttgaaact tttgagttaa 8040 tcatttctgc taccgcttca tcaaccgcag cgtttgaatc aatagcaccc aactgatagc 8100 gagctttgat agcgtcacgg aatggctcgt gcttaaacag aggaccccaa aattccgtac 8160 tgctcgtatc ttttgcccgc caggattttt cttcacgaat catctcaccg gtttcaacat 8220 ccaggaattc tcgtgcatac catccgtttt tcggtttaac cacaaatccg atatccagag 8280 ccatatcaag cagaccactg tatggatcga taccgccatc gaatttaaca tcgatgaaga 8340 acttactttt ctctttgaca gtacgtgatt tctcggcgtt caggacaaac tgatatcctt 8400 caagctcagt accatcttta atttgacgtt taccgatgat gaacacagta tccgcagaat 8460 acataggacc tgtaccacca gtcattaccg tcttactgaa catctcgatg gtctcgattg 8520 tatggttaac cgcaacgcaa ggaatgttct taatagagaa gtaaggagtt acgatacgga 8580 agagagactt cagacttttc gcacgagtca tatctgcaac agatttctcg ttcaaagcat 8640 cttcagtttc ctttttagac gccatgttac caattgagtc gataaacacg atgacttttt 8700 caccacgctc aatagcttca agctggttaa ccatatcgat ttttaattgt tcaaccgact 8760 gaaccggtgt atgaattaca cggtcagggt caacacccat agatttcaga taagctggag 8820 tgataccaaa ttctgaatca tagaacaaac agactgcatc aggatactta ttaagataag 8880 cactaaccat tgtcagagac atgttagatt tgaagtgttt agatggacct gcgaagatag 8940 tcaacccgga ctgcatacca ccatccaacg ctccactgat tgcgatatta agcatcggaa 9000 ttttagttct aactacatct ttctcgttaa agaattttga tttagtcagt tctgctgtca 9060 ttttagaagt ggatgcttta atcaggcgag attttaagtc agacattcat tatattccat 9120 aagtctccat tatatttttc tcacaggtta aaggatagag taattatatt actttgttct 9180 tgaagctatt aacagaagtt ccatttcttc ttggtgttat aaaccactgt ttccgtatct 9240 atttcatagt gtattttaca tccaacgcac atgccatgcc accagcaatg cattccatct 9300 gagccagtag ttccttcatg aacaaactca tcagatttac atacgaagca tctgaattct 9360 tcagccttga atatgttacc agctacatca gatttatcat agatgttcat aagaggtcct 9420 tggagggctt tcgccctcac agatatggtt ctaccttacc aaactcatgg aaggcctgag 9480 atttcactcg agtgttaata cacatacgaa ttgattttag aggttcgtca tcaccgaata 9540 aaccacgtct ttcaccatct ttagatttcc aacgggcttg atttgggaaa gcagcatgta 9600 gttgttcaag ggctctattc tgacgagcag tatcacgctg tgtagagcaa ccgccaggag 9660 actgcacttt gccggattta acgagatact taaacagagc cagatgagga tgacccatgt 9720 taatcaattt tagaaaagca taagcatctt cgttaaggtc aataactccg taaccaatat 9780 cttctgcggt gagtttagtc aaatcgtaga aagtattggt gaacccaaaa ctattctcgc 9840 gataatgccc ccagcttgat gtgattttga aaatcggcaa gcgagcatga ccatgataat 9900 aaccacaatc catagcagtc tcgacgtatt tgaccatatc atcaaatacc tcttggctca 9960 ttgcctcgcc tacaccaagt ggaacacggc gatcgtcgcg ttcacgaatt tcagtcagat 10020 gaattgtcgt atcatcatca agcatccaaa ttcgctgccc tgcatacatt tcagtaatca 10080 gacggcgagt tcctgcaatt ccatcaacat catcgggaat agtaacaatt ttagcagcat 10140 gaccatgcca ggtttcgtat gcttcttttt ctgattcacg tactacaaga tgtggaacat 10200 aaccttcagg aaacatagtc agggcagtaa ctgccccggc gcgcttataa cttggaatta 10260 caaactgaat catttccatt cacctttata atctttcttt gcaatatgag tttcaccagt 10320 ataagcatag ttatctacaa gatagaaatg acgctcatac acgtgcaaag acccgacgtt 10380 ccaaataatg tcgccaactg aataattttt acctgatgca ttcagaagtt tggttaactg 10440 ttccagaaca tagagttgcc acgcatagtc attacgatat ccaaagacga catcgtttga 10500 gcgcatattt accacagcgt gaactttatt gtcacgaata agatattgta cattgttagt 10560 acacatgaaa tcactcatac catcacgctc aaaatcatac tgcatttgag gtcgtgtgta 10620 aatcataatt ccacggcgag aatcaggatt actgataagt tcttttgcac agttagcaaa 10680 ctgtgaatag ttttgtgatg accaaactgc ccagccatag ttagaattaa tctcaccatg 10740 cttggatgca attgctttcc aaatagctgg agtttcacca ggaatatctt taacgaataa 10800 actttgagat ttataccact caagttcccg agcaatatat ccatcattaa ctgcgccaaa 10860 aattaggttt tcatctgcaa taaatgatgc acctacgatt tcaatagtct tcacacccgt 10920 cttatcaatc acaaattctt tgttgagcaa agcatcagcg aattcttgac ggatatcttg 10980 tactgtcatt ggagttacaa tcatgagacc tcttatttaa cttgctggat aataattgta 11040 ttctgctgtg cattagaagc agaccaaatc agcgcaatta accaaccgat aatggaccaa 11100 ccgaatacta gatttgtgat aaagattcca ccccgtgatt tatgcttacg actgcaagct 11160 acaaaggtcg gcaaaaaata gatgaagaaa agaatgatta aaccaaatac tgcttccatg 11220 ttaatctcct cagttagaca tgcatttgtt gtagatgtga ttttggagag attttaactg 11280 ctccatacgt tgtttatgct cattataact caatccgccg ttagcaaaat cagttaaacg 11340 aatctggtca ttcactgctg ccgcttgagc agtacatgta cgttcttttt gagttttacg 11400 cagacgctta atttcttcca gttcatgctt attctgctca atcatgtcaa gttccatcgc 11460 agacagctga cgattaggat tagctttttc tttcgccaac cgacgctcaa ccgcgagcga 11520 ttcagcagag acctggttgc tagcacgata gtatcctaca gtaccgccaa ttgctcgcac 11580 ctgtccaaca gaagaagccg ggacgatatc accttgtggc atttgacaac cagtcagcgt 11640 gagagcaacg ataacagcaa gtaacgattt cattgtaatc tcctcagtat gttatttcga 11700 gaaccatggt accacatcct tgtggtaaag taaacaactt tttaaaaatc gaacatgtca 11760 agaagagacg atttctcttc atagtctaac cctgccgctt cagacatacc cgtcagaggt 11820 ttaacgaacg atttttggaa cagaacactg tggtcaagcc acactagaac ttcctgtcgg 11880 atttcttgtg gcagctcagt gcccgatggc catgccatgc atttctcacc gtacgggtta 11940 ccttcacgca gcgggatgac catcaccttc tcgccttcca tgattggtgt tataccttca 12000 aagcctgcgg tagctcggtt atatgctaaa gcacctttaa cgtgatatgg tgtaccttta 12060 tctggatatc ctgcgccgtc atcatactta ccgatgttgt tggcagtctt aacctctgcg 12120 attactttat agtcaagctc acgatactca gactcaaact gcttataata ttgctgtaaa 12180 gattcttcac cttcttgcag catacgacga atagattctt ccaatgcgtt ctgaacagca 12240 gttggtgtag aactttgctg agtttccata cccatgattt tcagatgcgg ttctgcataa 12300 cgtgtacctt ccatatcata cacgttcaga gcatatcgtt tcttcgcttt ccaaaatcca 12360 ccaatgccgt ttgaacccaa cggaggacaa gaaatagctt cacggtccat gaacattaaa 12420 tgttctttgt tgttcatgta ttcacacatc tcacgatatg attggtcaat ccaaggttcc 12480 attttcttct taccgaattg gttcaggaat tctaccaaat cgttagtttc tttgaaacgc 12540 tcaagaccta ctttctcaat aaccttatca acacaaacgt aaattgagtc agtatcaccg 12600 gctactacaa acgaatgtcc ttcagtaccg cataccttgt tgaggtattc attaacttta 12660 cgttcaatcc attggattgc catttgacca aacaaggtga ttgctgatgc gttacgtaaa 12720 tcataataac ggaagtaaat gttacccaat gcaccataaa gggagttgat cagaatctta 12780 cggtttaact gattagtatt acccaagatt tcagcgtgtt tacattcaaa catcagtttg 12840 tcaaggcact cttcggtata tgtcagcagt tctgctttca tatcatcaga gaaatcttca 12900 tagacattaa cttctgcgaa tttatcgata gttccaaact tcttatcatt cagaaccttt 12960 ttaatcagtt cttgatttcg tttggcaccc atcattttat ttttccactc tttacgctga 13020 taaaatacct tcgcgatttc aactggaatg acaccatcta catctttacg atacatccaa 13080 ccatttggtg aacatgaata ttcatcagac ggacgaggag cagtcttgtt aatgtactca 13140 cccaacggat gaagtttaaa ctgtccaacg atagtttctg gtgaaatatt gacctgtcgg 13200 ataattgacg gatacagaga tgtcaagtca aacgacatga tataacgata tgcggcagga 13260 actggttcct taacatacgc accaggatat gattgtttaa catgagaacg actttgtgga 13320 ataaccttgt cttgttcttt cagactgtta aagatgatag cgtcccaggt tttaatcgga 13380 ctcattacac cttgatatgg catcttcgca taataagaca ttgagattgc caggtcaata 13440 aatccacgaa ccgcatcaat cgcttgtact gattcaacgt cgatgatgtt atacgaaata 13500 taccgttggt ggttagtttc acgcaattta ttgatcggac catcatatgc taatttacct 13560 ttcttggttt cgtaataagc aatgaaatcc aacttatacg tcggttggtt cgtgaaacta 13620 aatttcttat acaaatccat ataatcaaga atagtcacac ccatgataga ataaatttct 13680 ttatcaccat acatgtttgt gataatctta gatgaaactt tattcagagg agagaaccgt 13740 ttcatcgtac gctcaccaag aatctgtttc acacgattca tgatgtacgg aatatcaaat 13800 ccttcaatgt tccatccagt aaagattgct gggcatttct gttcccaaag attgatgtac 13860 tcaagcatca tttctttttc tgaattgaac ggcatatata ctacgcggtc aagaatatgt 13920 tgtggaactt catcaccgcc ttcagaatct aaacgagcag cgagtttctt gtcccactct 13980 gaaacggaac cataaagcga atgcagtaaa tcaaacacat agaacttatc atcaactgaa 14040 tcatagtgag tgatagcatc aatttcgtat tctgctttca tcgggtctgg gaattgggat 14100 gccgtaacct cgatgtcaca gttcgcaatt cgaatgaatt ttttattgta tacgatttct 14160 gaaccgtaag tatcactgat atacgcgagt ttgaaatcat ccatacccat tgcttccatt 14220 cccatatctt ccatacgacg catccaatcg cgtgcatctt tcatagttgg gaatgtattc 14280 ttcttgcaat acttgccata gatgtctttg tactttgttt cttccatgca atgactaaac 14340 ataacaggag aatatggaac acgacgcatg cgttcctcac cagtagaatc gatataacgt 14400 tctacaatgt cattgcctag agattcaacg ctaatataaa attctttcat gggtttcctt 14460 tgtttataga ccgagttatt agtctttagg tgggataatt atactccgag ttttataaag 14520 taaaaggccc gaaggccttt tcttaaactt caattacttg cttctgaatc cgaggaactc 14580 gattcttatc atatgtgaag cacatcataa cttttcggtc aggatatttt tctaaagttt 14640 cttttacctg atactgaatt tgttcatcaa taggaagact gaaccattca ggagcaggaa 14700 tcctgatatt tttaagtttg tcgtaaaatt cttggtctgt cattatgcac caatcgtata 14760 tttagatttt aaggtccatt catgtttctg cttgaacgta atgacccgga agttattctg 14820 catctgggca agagtttgac cacgattaat actcagtaga ccccagtcag cgagcagttg 14880 tgcgattgag tctcgacgaa tttcatcttc caggtcaata ataacaggac ggccgtcaag 14940 cttcaacatt tctttaaaat gtacaatata gtaacgacct tgtttctgga gaatgtggca 15000 gctttgatat agtaccttat ctttgttatt agcaattccc atacgagtca gagtttcttt 15060 aactttcagg aagtcttcag gctgtttcag tgtaatttca atcatcttta ccattccaat 15120 gctgttttct taagagtttt ctgttctttc acgtttttcg tgattgtctt gaccaattca 15180 tcagtcacaa gacctttcat tttcttgaga gcaggtttaa gtttattttt ggcttccaga 15240 gtctctctat acatcctagc atcaatcgca ttgaccttgt aatatgtcat tataacttga 15300 agaatcaatg catcctggat gttttctgtt aacttagccc atttcccata ccgacgacct 15360 ctaggaacag aggccatcat atagttatag tgtgcttggt cagataaccc ttgaccaaca 15420 aggttcataa cataaacagc aggcatacag tcggcatgct gagaaagagc gttttcaacc 15480 atgaattttg aataatccat agtcgagatg ttcaaatgct ctttcttttc attaatagaa 15540 ccgataatct cgaagaattg attttctgcc ttttctttat atgaatcaga taattcctgg 15600 actttcgccc agtctttacc taaccatgcg atttggtgtt cattatactg atcatcatct 15660 tcaaataaac tcatcatttc cactgcatct ctacaacaag ttgaataagc atataaacca 15720 aatgtaattc aatcgaagct gctacaccat gatactggtt attttcacca atgatttcat 15780 acattcggat aatacttggg ccagtaacca ttgtatacag ttccgaagaa agtttatcta 15840 cgaaccaagt atagtctgca gcatatttcg gagcaagagc acggagttct ttgatgttct 15900 tggttttaat agcttcaatg acatcttcaa ttgagccgcg gtcatttaga acaatagaca 15960 agatacctgc atcaatcaca cccttagaag aataatgatc aagcatgttg atggtcttac 16020 ggaattctgg gaaattcttt ttgaccaaag cagctacaac tttcttatct tcaactacca 16080 cgccttcatt ttcacaaatt gcgagacaac gtttgagcat ctcgatttgc attggcttaa 16140 catcagatgg agatggttta ccaaaattaa ttacacggca acgagactga agaggtttaa 16200 tgataccatc aaggttgttt gcagtaatga taatagtaca gtttgtgcta tacgcttcca 16260 tgaatgaacg cagatgccgt tgagattctg caagacctgc tcggtcgaat tcatcaatca 16320 cgataatttt ctgcttacct gcaatggatg cagaacttgc gaatgcagtt aacggtccac 16380 gaacgaaatc aattttacaa tcagaaccat tcacgaacat catttcagca ttaatgtcat 16440 tacataatgc tttagctact gtggtcttac cggtgccagg agaagtacta tggagaatta 16500 aatgaggaat ttttccttta gctactaaag ccgaaaaaat ttctttatct tcagcaggca 16560 atacacactc agaaatagta cttggacgat atttctgttc ccacataaag tctgcttcgt 16620 ttactgtcaa tttcatttat atttcctcat tcagattaaa gatggggccg aagccccgaa 16680 gttattactc aaaatcaaag gtactgtctg cttccattgc tactacataa gaggctgatg 16740 caccttcaaa cttcgctgca gtctgtttct tggagccatt catttttgcc cacagcatca 16800 gtttgtaatc accaacagtc attttcatat tgctcatgtt gatgatgaag ttgaagttac 16860 cttcgccatc ataatcaccg agcgtcagag aatacttcgg acgagtcagt gcagcgtctt 16920 ctactttatt ataaccacgc agaacaattt taccatcaac gttggtgata gcaattgtgt 16980 caatctgcat gccacgagat actcgcatca gctgttgcag gtcttcacct ttaaaatcga 17040 taattacgtt tgccaccggg aatgggattg gtttagtcgg aaacacgatt gtgctcgggt 17100 cagctgctgg ccagaaaata gttgagcgag catctttaat tgccagatta ccatcttcct 17160 gcatgataat atctgcatca tcaccaacca gagacagaat gctcaggaaa ctgttcaggt 17220 cataaattgc tacatcagta tcgatagtat cagagattgt ggcttcagca taagtcgtac 17280 cgttaacagc acgagtcatg ataaaattgc caggtttcag catgatacca gagttgatgg 17340 tggagaagtt tttcagaatg ttcagagttt ctttagagaa tttcatttca atacctttta 17400 attaagttca ggataattat atcaagctgc gaatgtagca gttaattctt ctgcaacaat 17460 ctgacctgcc gcaacgagtt gctcatcagc atctacgcag taatcatttt ctagacgttc 17520 gccaccatga cggtcagtaa caattttagc accagccttg attgattcgt tgtaatgctt 17580 acgcatcaat tcaatccatt tttctgcaac ttcgtcgtca atagatttat agaaagcaaa 17640 gcgagcttca gaatctttaa tcttatcttt aatagctgct ttagtttctt cagttagagc 17700 cagaacccaa gatttacgaa tacgattttg gttattcggg ttggagtctg cacgtacgtt 17760 tttaacctgg atatctttca catcaacaaa attaatcatt atatttacct taatcgtaat 17820 aatcttcaac catccaaccg ggattcctgc tggacatgac tctattatat tcatttcctg 17880 taaaagcatc tcgtaacatt tcttctgtta ctaagtgctt ttcatcagaa aacaaattag 17940 ttaacacata tcgctttact tcaggaaagg ccagcagatg ctggccagtt gtaaactcat 18000 tcattccatc accgtaaatc gtcctacttt cttcatttga agatgttggc cgtatgcctg 18060 tgggtcatgg tcacggtgag aaataataaa cacattagca tctaccatct tattcagaat 18120 agcagttatt gccttaacac cttctgcgtc ggtagccgag tcgtagactt cgtcaaggaa 18180 cagacagttt attttaacac cagaaacctt ttcagcaata tcacgccatg tgaatagtaa 18240 tgctatatcg attcgagctt tttcaccttg actaaacgag gcataactaa actcttctcg 18300 tccacgcgat ttaatcgttt cagagaactc ttcgttcagt gtgaacgaat aatcagcttc 18360 cataattttt aggtagctgt taatttgctt attgaacatc gggatgtact tcttgatgat 18420 agctccttta ataccggagt ctttcagcat ttcagttaaa atacctcgac gatatttttc 18480 cataaccaaa ttagttttga cgaggataat tttatctaat tcttcttgta gcagttcaat 18540 cttgtcagag ttatcaatga actcctgtga tgctttatca attgctgctt taatacgacg 18600 tgctttatca actgcagtta aagtcatctg cttcaaatta ctcatttgat ttttgatgtc 18660 tcttgcacgt gaccggacag tgttatactc gcgagccagt tcatccagtt caccctggcg 18720 cgtctttaac tcgccaagaa tggtattaca ttcttcaaca tgatgattaa tcttagtgat 18780 tagagtgtca ttagaatgca aatcctgcaa gcacgttggg caatgaccac ctttatcata 18840 caacccaaga acctttgagt atgattcaat tttagaacga atcttaaagg ttttaccttg 18900 aacttcttga attgactctg ctgggtcatc accaatcacg agttcaagca gttcgctttg 18960 aagagtttct aattctgctt tatatcctcg tgcctctttc acttgctcat catacatcgc 19020 ctgcaggcga gctacgttat cgccagaaag tttcttctgc ttttctgcgt actcatgatg 19080 agttttaatt tcattggtta atgcttcacg acgaacatca ttaacttgaa tttgctggtt 19140 aatttctctg atttgggttt tattcagttt gtccatatca gccaggagag acacctcaag 19200 caagtcttca acgagcttac gtctattccc agtggacaat cccatgaatg gagtatatcc 19260 agcagttcct agcacaacaa tttgcttaaa tgatgagtat gacattccga taaggctttc 19320 aaagtatgat tggaaatcct ttgaacttgc agcctcatca agcttgtttc cgtctcgtaa 19380 aatttcaaag acgtttggtt tctgccctcg ctttatgtag aaactatggc cgtcatactc 19440 catccataat tctactacag agtccttctt attaaaggag ttaattaatt gacctttctt 19500 aatatcgcga aatggttttc caaatagagc aaaggtgatg gcttcaagca tagtactttt 19560 acctccacca ttcttgcccg tgattaaggt cttttggcat ttatcaagtt gaatgtcaat 19620 agccgcctga ccaactgaca ttatattctt atatttgaca cgatttagtt taaaagtctt 19680 cactgatttt gtgcctcaat atataactgt ttagacataa cttttaaggc cttgatgtca 19740 tctttagaca ggtcttcaag tgcttggata tattcttcca ttaaatccaa taagctttta 19800 acttctactt cttcaccgtc ttcagactcg accgagttat ctaccttaga aacagttctt 19860 aattcatgga ctactttttc gagttcggat tcaaactttg gaagattttc atctactgca 19920 gtaacaataa ttcgcactgc aagatttctg aactcttcaa aatcaacttg ccctgtgaca 19980 ggataaatta attttctatg ccatgtgatt tcattaggga cgaaatcaaa ggttgataat 20040 ccagtgtctt gaacccagaa tccgcgtggg tcgttctcat cacccgctgt aagcgtccaa 20100 ggcgttccga tgtacttaac gtttgctgcg cttgagatgg tgtggaagtg tccagaccaa 20160 acttgcttgt actttttgag gaaatctggt tccaacccat gagatttcat acctttataa 20220 aaatagaagc cattaagctc ccagtgacca atgcagtatt cagcagacga ttctttgata 20280 tgcttcataa tttccgatgc gttctcttca cacatccatg ggcacaagtc aatcaaagtc 20340 ccatcaaaat ccatagtcgt aggtttatca atcaccgtga tatggtcata cttaccaaga 20400 atttcagttg atgcattggg tgtcaacgta ttcttgtagt gcatatcatg gttgcctaca 20460 atagtgatta aattaattcc ttctccttca agggattcag caatttcacg agcaaattcc 20520 attgtcttat gagtaatggc tttgcgaacg tcaaaaatat caccatactg aatccaagta 20580 gtgatttcat tttcttttga atattcaatc gcctgttgaa ttccatgacg ttgaacgtct 20640 tgaacccatg ggtcatcgtt gcggacacct aagtgccaat ctccagtatg tagaattttc 20700 atataacctc tctaatagag tttaatttta tattattccg tgaatagcaa aaagggcccg 20760 aaggcccatt acttattttg tcattaactc aaattgttct ttaaagcaat gctcagaatc 20820 ttggtgttct acaaggaatt catatgcttt atttcgctct ttatcataga gcttccggtc 20880 agatgacaga tgtttcattc gttcaaagac ttcattttta ttttcatcat tcaaccacaa 20940 aatgccagaa tcatgagaag tcaacggctt tccatcaacc cggaatttca aagcatcacc 21000 agtagcttta tggaacacag gaatagttcc acaagcgcct agttctaaat gtgtgtattc 21060 cagcgaacgc tcaaggaatt tatccggaag acgtgacagc tgatagccaa atccagactg 21120 agacatacgc tcaagcatct cagagttaac atatcggtca agaacttgag gattcagacc 21180 tggcccagtt ttaacctgat gataatggcg gcaataatca atttcatagc gttctttgat 21240 gttaataaat gcaggactgc gttctaaccc ttccaagata gtcgttttgc ctgcgggccg 21300 cagatgactt tcatgaaagt caaacatcaa gaaataacct ttccatgtag tagtacgacc 21360 aatccaacga tggatatcaa aatcaatggc agagaagtct ttccaatact tatcacgaat 21420 tgctttgatg ttcatagcag gttgaaagtt ataaaccgga ggagctgagt cagaatcatc 21480 aaagaaactc aacccgccgc ttggaaaata ttcttccatt agcacggtat taaaatcgcc 21540 gtttgagcta tgactaaaca gtacatcagc acgcttaacg gtttcttcaa gaccagcatt 21600 tctacgaagt gacaatgctc tatggtcatg ttgatatacg actacccgaa cttcaggttt 21660 aatgttctct atgagcttct tatagttatc aatcgctgct tctggagcgt tgacagcagg 21720 tactgagttg atgataagaa tgtcacatgc gttaagcaga gataaagtct tatcgtagtc 21780 atctgcaaga gacacaggaa tagttacatc tttatagcta tgtgctctat tacgagtaaa 21840 cgctttatct ttagcgtaaa tgatatttac ttcatggcca tgttttacta accactcacg 21900 gtgctcgaga ctgaacttgg ttacgccgca tccctcaagt ccgcgagcca ttaaaatatt 21960 aatcttcata tattgacctt tgttgttaat tttggatatt ttaccattcc cgtaataaag 22020 caaaagggcc gaagcccttt aaattttctt gtatacaaca taacccgctg cttcacatat 22080 acgcttagct tcttcaaagc gtctaagcat atctacctta gcattatgaa tcgcttcata 22140 atcgggagca ggtgcttctc tccgagcagt atcacattta tagcagaagt aactacgctt 22200 tggtcctgta taacgttctg aacaattact gcaccggcat gtataatttc cttccggcca 22260 atcatgccca gggttagaac ccatcaaatt cgtcatacat cccaattctc ttcactagta 22320 ataaaatcag ggtgttcatc taaatcaatg aatccccagt tttcttcgtt taccattcat 22380 accaccgttt aacctggaag gtgtcaaccc agacaagaga gttcttatct attagcttac 22440 atccttcggt agagcctaac acgcgatatt gattatctgc tacctttact gccatcgtac 22500 cagtcgcagt gtttaaagta aatcctgcgt ctttacgaac acgtttaaat tttacttgta 22560 ccagcattta gaatgtccca aacagattta cgagaggtat tccagcaagt cagaataatc 22620 tcatcattaa aaggttgttt taaaatagta cgcagttttt caatagcata cttgtaagca 22680 gggaaattat tgtctaatac cgcgtctcca gcatgagctt ttaatcgctc aagttcacga 22740 cggtttttac gaacaatttt gttggctcga gcaatagctt gttcttctgc cgcttccatt 22800 agtttctgtt gaagttcgtc gcgctcttcc tgggtaatat tgttcatgtt attcctttgg 22860 atggtaattt atttcaaatg tgaattcagt atcagtccaa ttataactgt gttcaattat 22920 agcagaatct gacctgaaat cagcgtcatg tggatttttc gggtcaatgt gaatatcaag 22980 gtcaagcacc tcccttaaat acatctttag caaataaggg atagcgtcta ggtcttgcac 23040 atcttctaaa aacccgtcga ggttaatctt cagcctcata taaaaattcc agattaggtc 23100 catcgcttgt aggttcgctc tttttagcag accctggcgc cttataagcg gtggattcat 23160 actgcgtcat tttgtcgtag atgtcctgaa taaaggtttc atctgctaac gcaaccatat 23220 catcgtcccg tgaatcatac acgttgtgga caaaatagct gtatttcttt gccatttctt 23280 tgcgttcttt tttgatacgc tgaacgaatg cattgaaaca agcttgggtt atatacgcat 23340 gcgggttatc atacttagtt tcatcgaagt tgattaagcc tttaattgcg gcttcaatcc 23400 cgtctgaaat catttcttgt ttccaggatt gggtgtatcc tgaaaagttg aaacgcttac 23460 tcagaccttc tgcgatcagc ataatagcaa ggccgatcgt atcgttctgt tttactactc 23520 gaggaccgcc agcagcttca gactcccggc acttctcttt ccacgcacag attgatttat 23580 acagttcctt gttatttaca taattactca tattgcctct tcgcttcaat taataatatc 23640 tattataaca aatttgggaa gcgagaggat taaagcatta cttaatcaat tcagcgcatg 23700 caattaattt catcatgata cgataaaaat cgttatacgt gaaatctaat ggaacatcaa 23760 tgacggcttc aaaatcttca aatacacgct ccattccata accagcgata tcatctgatt 23820 cagcatacca gtacgttcca tcttgtgcaa aagttatttg gctattttca aggcagaaca 23880 cgcctttaat tttttcatgt gtaagagtca attgaatttt catagttcac ccttcataat 23940 acgatagcat tggaacagct gttccatgat acgtttgaac tcaaccaaac taagttcaaa 24000 ccactcagat tcatctactt catgcatcat ttccatgaat gaagagtata aactttcata 24060 atgagtttca tttaacatag aggcatgcgt ttcccaatac ataccctctt cattgtcaaa 24120 ccaaacaccc atataagaat ctatagtaaa tccgccaatg ccttctacta caatcataat 24180 ttggtttact ttagccatgt cttcaccgag tcaatagcgt cttcaaattt agagaaagca 24240 tccacggatg tgtattcatt ctcaccagag cgttcataaa tccaaaacgc gtcaaaatct 24300 tcttcaatga tgaattctcc gttaggagtt tcaatcgtgt ttctgccatc aggcgtttta 24360 gatataaacc atccaagaaa accaacttct gcaatctgtt cttcagtcat ttaaaatttc 24420 caccaattga ttatagttta atgcttttcc agaagaaatc ataacattac aaaatctgta 24480 taatgcttct tttgatactt tatacacata atcagaagtt gttataatgt atgaaatacg 24540 tacaaatgtt ggggattttt ctgccaattc atacgccagt tttctagctc tgccaatatc 24600 atcggcaaac ttggtatcag caagcaaaat actatcaaat acccaacggt tagtaaaaac 24660 ttctgtgtat agaataacct tacgcatcaa gatactctcg cagttcctgc tcgtttaacc 24720 cctcttgcca catctctgac ggagatggaa gttggctgtc tagagtggat gaatcaattg 24780 gaaatactct gataattacg ctagtatctt catcccattg atttgcgagt atccgtttag 24840 cttgactaat gtcaggctca gaatgagccc ggatatactt aatccttcta tgccatacac 24900 cggtaggaat agatgcgcac acgatatatg aaatcatttt gccgccttaa ccgctttaac 24960 accgcggaag cctttcttac gttgattctt catcttacga atagtgcttt cagaaatttc 25020 accgataccc ggagtgattg gttctacacc aaaggctttg atgccaaatt cagacagaag 25080 ataagcaacc actaattcac ggatgcgggc tttaccaatt ttttggcctt cttctttcat 25140 cgtaccgtga agctcaactt cccactgatc aagcaaagac ggagttacac aacgtccttc 25200 ttccagcatt gcagatactt tatcataagc aaaagagttc agtacgtttt tgattgcttg 25260 ggacatatta atttcctcag gaacgattga tttgacagag gagattctaa atcaaatctc 25320 ctgtagcaaa tcaatctttg agagatttta gctcttcgag catatcatag tattctttac 25380 tagcaaccgg agctacagtg cagtggtagc tattgaattc atggtatttc acgaagcgtt 25440 caagttgcca ctcaatcaga ttgttaattc ggtgaagcag aaccccctct gaaccgacgt 25500 agacaactac ttcaaattga agcccatccc aaattctggt acggacgata tcacctacat 25560 taaatgtttt catgcgatgt accaatgttc gttttgccaa gactcaccct tgtaccagcg 25620 agtcatatca tatccgttct cgtcacggat agcgccatta cgcatataga agtactcgtc 25680 atcagtaaaa tactcatgct ttactttaca gcctttactc atagcttcta gagcttcttg 25740 ccaatttaac caattcatat tttcctctcg agttaaacgg tatgctgtta tccgttgata 25800 gggctatggt atcactcatc aactggcttg taaacaactt tgtgaaagga gtttagaata 25860 aaagagaggt cccataggaa cctctaaatg aagggtatag aaatatacag aaggtggtca 25920 agatgacctt agaaaggaac tggctaatct tctatgatat ctggatcgta tccagcagca 25980 ataagattgt ctttaaacgt tggaatgtca tactgcttaa cgctatccat aaaaatgaca 26040 ggataccgaa tagcaagcga tggatagcac ccgatgcgtt tagcaagtga ctcaatcaac 26100 ggacggtcat aaaccggttg gccgtcaacc tcgttgatta cgttatagaa ctcatacgga 26160 agttgcagct tatcgagcaa gtcacgaact gctttacatc cagggcatct ccaaacttct 26220 tcagggatgc catagatttc tatcatagtt cagccttaat ctcagaaatc aatctttcaa 26280 ttaattcaag tttatccgct gtagtcatag gataaatttt gtcaacagtg gcttcttcaa 26340 gatagcaacg gtcagcatcg ttaagtatac accactgatc aaaatcatca gcatctatgc 26400 taacgccgtt gaaggtctta actcgttcaa cagacccgtc ctgcgtcaga gctgttacca 26460 aaaatggttt aaacttaagc atgttgtaga attcaacatc ctttgacgac gcgctattta 26520 gccatttatc aacagagtct tctttaaact tgtaccactt atcgcaacaa aataattcta 26580 tcatttcatg acctgttgaa gtttggcagt cagagtatta acacgcttct gaaattcttc 26640 attagacagt ttttcatctt tcttagtagg attaatccag tcagaaataa tgatgagaac 26700 aataaatgga atagctacga aagcacctgc ggttaatgca accagcgcaa taacattaga 26760 aataaattta cgaatagcat taatgaattt cataattttc cttaaatagt taagatgaat 26820 gctgtcatag ccagaaattc tggtccaaac agttcagtag ccatgtggtt cagagtaaac 26880 ataattttgt aagtcagcat ataaatttcc tcaatcatgt gtccaggtag aaccgtttct 26940 tacccagagt ctttggttat cagaaccacg ccaattttta gtggttggca gtgattgctc 27000 gtatttccca tcaattataa catcaatgtg ttgtagcaaa tctaagtctt taatatcttc 27060 aaatttatat cctgtccaca tccagatatc tttctccgga aatcttgctt taacccaaga 27120 aactaaattt gaaatctctt cccggttctg tggataaagc gggtctccac cagttaaggt 27180 aagaccttgg atatacgatt tgcttaaatg ggatgcaagc tctttaacag tattcatagt 27240 gaataactgg ccgtttctag cattccaagt agatttatta taacaccctt cgcatttatg 27300 caaacacccg gtgacaaaaa gaacgaccct gcatccaggg ccattcacaa agtcagaagg 27360 gtagattctg tcgaaattca ttgaacctta cctcattacg tgcttctact tctgcatcat 27420 atttccaggg ttcatcagtt tgaatagccc cagccgatag tccactttcg gggtcacggg 27480 ttatagcaat tcccaacgga tgcagaacct ctttgttgat tttccaaatc aatccccact 27540 cgctaagttg gttccaatca acttgcttca ttggtttctc taacatgttt taccctatgc 27600 ataatttctt tgttcttacc aagattaaac ccacgctcag aaggattacc aagatagcca 27660 caagtcctac gaattgtatt catcttcttt ggatcagttt caccacaaat tgaacacgtg 27720 aatccgtttt cagtaggtgt catctcatga gtagaaccac aagaaagaca tttatctact 27780 ggcatattaa caccaaaata atccaacttc tcgatagcat agtcccatac cgcttcaaga 27840 ccttcaaggt tgcgcttcat gtcaggaagt tcaacataag aaatatgacc acctttagca 27900 atagaatgat atggtgcttc acggtcaatt ttttcaaaag gcgacaggtt ttcttctact 27960 gacacatgga aactattagt gtaccagcct ttatcagtta cgcccttaac atcaccaaac 28020 ttagcttggt caatcttaca gaaacgatag cacagacttt cagccggagt tgagtacaga 28080 ctaaaggcat agccggtttc ttccgtccac ttgtttagct tagtgttgat gtacttcagg 28140 acgagtttac cgcttccttt aaaagtaagc atatcaaatt cgtggatgcc aatatatcct 28200 aatgaaattg aactacgtcc atttttgaat agctcaagaa tttcatcatc aggtttcata 28260 cgcacaccaa aagcaccttc ctggtaaaga ataggagcaa ctgatgcagt aacaccttca 28320 agggatttaa ttctagttaa aagagcttct ttacaaatat caagacgttc atccagcagt 28380 ttgaacagtt tattactgtc atctgaactt ttataatttg catccagagc tatcctaggg 28440 aggttcagtg ttactacccc tagattatta cggccatcaa gaacgggttt gccagaagag 28500 tctctccaag caccaaggaa acttctacag cccattggag atacaggagt ttctgaaccg 28560 gtaattgctc tattatttcg agcactgatg atatcaggat acatacgttt agctgcgcat 28620 tctaatgcaa gctgcttaat atcatagttc gggtcttctt tacgtagatt aatgccttct 28680 tctacaaaca tcacaagctt tggaaagatt ggagtaattc catcgcgtcc taatccacga 28740 atacgattat caagaatagc tcgttgaatt aatttttctt cccatgacgt tcccatacca 28800 aatgtgatag tcacaaacgg agtttggcca tttgagctga acaaagtatt cacttcatat 28860 tcatacgcct ggaaagcatc aaacacgtct ttttctgttt ttgaaatagc ataatctttt 28920 actaatgcta cctgatattt gcgagcatca cgcacatgtt tagcaaatgt cttctctaca 28980 taaggagcaa gaactaaatc aacattagca aaggtagttc caccatattg gtgagatgct 29040 acttgtgcag tgatttgcgc catgatagca gtagctactc caatactctt aggagtttca 29100 atttgagcgt taccaagttt aaagccattc tgcaacatac ccttcaaatc taccaaacag 29160 cagttggtga aaggcaaagc tggactgtag tccatatcat gaaaatggat aacaccttct 29220 ttgtgtgctt ccattacaga gaaaggaatg acctgattgg cgatatgttt agatacgata 29280 ccagccatca ggtcacgttg ggtaggaaaa acacgagaat ctttgttagc attctcgttt 29340 aaaaggtcct tgttggtttt attaataagt ccctggattt ctaattcgat attcatttta 29400 aactcttacg aagctgcttc ttgtattttg aagcaagttg tgattttcca tcactttcct 29460 cgtatgtaaa cccatgcaat tccatttcag caatcatctc aggtttacca agacgtgaaa 29520 agcgtttagc catatcggca acatattgcg ggtgaatatt actgtcttta cgattctggc 29580 ggagatagac cagcaaattc tctaaccatt cgaggtagtc aatatcttga ccttttaaac 29640 cagaacggtt gaacttatgc ttcatttggc cttctgccgc attgcacagg ttacagagca 29700 agcctctgac ctttcctgca ttgtcacctt ctaacgcatg gtcatggtcg aggtggttct 29760 tttgaatgtc ctcatctaaa ggacgtttgc agcaaggaca taatccgttc tgtgcctgat 29820 atagtttttc tttttcttct ttatataact taccggttaa taacatactc ttacctcagc 29880 gattagataa gagtatttat agttaaatta acgagtaact accatacata tttttagatg 29940 attctttaat acagtatgag gtgcagaacg caaaaattcc agtgatatta tctgcatgat 30000 aactatagac ttcgttgcta ttcgcatcta caagtttgac gcttttccat gccatggcat 30060 cgatatcatc ttcataatag ccatctgaaa attcaatgat atctccaact ttaattccat 30120 ggtctttaaa gacgctttta atctggcgat gcagctcaga caggtctagg agtttaacct 30180 taattgattt agaaatgcaa gtattagaca tggcgaactc caagacgttg ttcaagcgcg 30240 acaatgtaat ccgcagcttt ttgcattaaa tcatactctt ctgaatcaca attttcctgc 30300 ccagcaaagg cgtaaagagc tctggtaatt ggaacgattg caccttggaa atgattaagt 30360 ttaatttcag aaatcagagg aacatcttca ccttgaccaa tttctttaat ttggtgcatc 30420 gtatcttcgc tgtagaaaca ccagaaccaa gattcgccgt gtggagttgg gtcgttaata 30480 gtaatgattt tatttgtcag taaatcaata actgcagtga ttcctaccag ttcaaggtcg 30540 tcttcattat ctgcagaaat aacttgaaac ttaaatcccg gaatgaacat aggaaattgt 30600 tcgctcagtt catcatcatt ctcaataact tcaaactgct taccaataag ccccattcac 30660 tttgtcctca taatcaagca attcatttat ggtaggttca gaggtattat aatcctcttc 30720 aggaatagca tcttcctctg gctcgacagt ttcccaacga gccgcatacc agggttttag 30780 acctttgcta ctttgcatgg tgttggttca gaatcattag cagaatcatg ttcaatacgc 30840 cattcaactt cagtgcgagt aaccactttt tcatgacgag taacgatatc tacttcagga 30900 ggactataat accaatcagt atgatatgag cctgaacgag attctgatac catgaaatga 30960 acgccacgtg ctggataata ccaaatttga gtgcggtctt gatacttatg ctcttgtgtc 31020 cagtctccat cttctactaa aacaaagatt tcttctacat cgtcatctgg agcatttggc 31080 ggatattcaa aatcgtagtt gtcgtcccag ccaccggtga cgccagcgat atgcttgatt 31140 tcttttacta attcagcgtt agtcatttta acctcgcagc ttctgtaaat cttcatcatc 31200 aatccagctt tctaaaccgg atggaagcgc acattcaatt tcccacagca attcttcaat 31260 tgcttgcaag cgttcaagct cttctgctga aatagttacc atgcgtggag cttttaaatc 31320 gccaatatca taactcatag ttcttcctca tgccaagaac agtcaacttc aaagtctgga 31380 ccaaggtctt catcttccca acgccaagac cctaacggat taccagcatc atcgtaatca 31440 atttcaagac caatataact ccactgaaca ccatgaatgg tatttccttg ctttacaaag 31500 aattcacccc attggtgcat gaaagcatac tgcggatcag atatagctct ttcaatcatt 31560 gcttcacgaa gattacgttc taaatctact tggtcgcctt caggaaaaac aaactcaatt 31620 gggtatttca taatttcacc atacactcgc cgtatttcca tttagacata actttaactc 31680 cattagagta agttacctct acctttgctc gatgattttt aatttgttta atctcgccgg 31740 tttctaatcc accgtagcca taataaagag ctacaatatc accctcccga aggagggttc 31800 cacgataatc atgcattgaa tttgaattta cggagttcat caaaaccgcc gatatgtgta 31860 ccgtcaggag caaaaatctg aggcatagtt aatccaacct gtgattcacg acctaaacgg 31920 cgaagcaaat cactgataac cacttcatca aatacacctt tttctggcat tacattgatg 31980 aatgcatact cttgtttctt aacatcgagc agacgctttg cattatcgca aaatacacac 32040 ttatgaatgc tgctgtcgta accaaaaacc gtgaacatct tcttctattt ccttaaatac 32100 ttgagcttga acttggttcc aactcgggtg tttatacgct ttataaacgt taatcattcc 32160 aaggcgcttc gtgacttcgc catcaattgc agcttgggca aaatttcttc cacgggtcat 32220 agctcctttg agattggaac tgttagcaat ttgaccagtc tcattataat aaaccgaata 32280 catgagtagc attactcgtt cggcttcttc catatatcgt ttacgagcca ttttcagcct 32340 tagtagttat aactaatgtt ttaccatcta acgcatcgag aatatctttg atgcaattat 32400 ctggcattgg ttgaacgcta gctaattgct tggcaatatc atcaggaatt cccatacgtg 32460 gtatatttaa tttgctaaaa tcaattttat ccattagcag ttaccgggaa gtgttctgcc 32520 aatttagcag caatggcagc gttaatttga tcagcgaaat tcttattcat tgcgttaaca 32580 atgatttctt gaattcggag attagctctt tcaatagaca tcttaatacg accttcagct 32640 tgcttaacag cgtcatcaat agtttgacga accatatcat caatagcatt tttagcgcat 32700 gattgggcag cgttacgcat catctgtgac atttcttctt tagcagacat atcattccaa 32760 ccgcgagtat ggaacatctg ctgaacttgc ttcttaactt ctgctcggac atctggaata 32820 gtcacagcag caatattaac ttcagattgt actgcttgtt ttagtttatt ctgggaatct 32880 tttaacacca tttctttaac gatgttattg attactgact gttgcagttg agcacgggct 32940 gctgtacctt ctgggaataa ctggcgtact gcataagtat ctaatttaat gtcaatcatt 33000 ttaccttttt cactccagga atattagaga tagtttcaaa tacttcgtca aagttatctt 33060 tatcaacagt gactaccata gtgcgagcgg tctgtttctt tttccaacgt ttaaagaaag 33120 ttgcaagact caaatcatgg gaagtgaaga aatcatcggt tttgtaaaca tatccgcttt 33180 caatttttac taccgcatca ggtgaagggt cttcatattc ttctacttca acatcatcaa 33240 agaggattaa agtgtcatcg tgataatagc cttcccagaa ggcttcatcg ttataaaatt 33300 ctttccaaag tgcgccagtg gttttcattt aatcaccttc ttccaagctt cgtgagcagc 33360 gcatgctaat acttcatcat cagtcaaatt gaacttgcct tcattacgac gagcaatcat 33420 ttcattgaat tcagtatcag ttctaagcat catgttaaga actgtaaaat ccattgtcgc 33480 tcgaagatat tctttaagct gcatagggtc gatgccactt tcgtatgcgt caagaatcat 33540 atctgcaatg atgttatcaa agtttttgtc ttttatgagg ttattagcat actcgacaaa 33600 aaacttagta ttagcaccag taatagtttt agtaatcatt ttaattttct ctcaaattta 33660 tgcttacaag tccgacattt cattttcaga atatcggttg tccaatcaac aagctgtact 33720 tgaatactac cacatttttc acaaggcaca acttgtttag ctgcagcttc tcgacggtct 33780 accatttcaa gacaggcatc ccagtcaatt ttaaattcag gtacaggtgg atactcaaac 33840 tcaatttcaa ggtcgttatc atcaacgacc atgtcttctt ttaattggtt tttcacagta 33900 agctccgggc atactcgaga gattcataac gctctttgta ttcgttaagc gatttaacca 33960 aatctgccat agctaattca tgtttggcca attcagcttc ttttgtatca ataaaccgct 34020 taactgattc catttcagct gtaatactat tcttagcagt ttcaatatga tttactggtg 34080 ttaacggaag aggcttaaca acattgagat acatatgtgc tacatcttca tcaataactg 34140 gggttgtgct caatgtttta ggaaaaatct taaatgggtc caaatgcact tcaagaacag 34200 atgagttttc accttgctgt ttgcaacatg attttttaac tacatccata tgctctaaag 34260 cagtacgaac ttgcgctaaa agcgcccggg ccggatactt tccgctggac aaatggctgt 34320 taatatgaat tcgtacagtg acattgtcaa gttcttcggc acgaatgaat gaaacaccct 34380 taggatttct agaactagta gaagatacct ggtatttcac acggtcatcg cctttaagta 34440 agcaaattga acgattaaga atacgacgca ggtttgcatt aaattcagag cagaagattt 34500 gagcagcgct acggtcatgt ctttcttcag ttttaaacgc ccctgccgca aagctataac 34560 gctgaccgta aattttagca ttgccgatag caaacttttt gagctgtttc tctgctgaca 34620 ttgcacctaa ccagcgagaa cgacgaatgt tttctacaac aaaacccgca taattggctt 34680 catgcgctgc catgctattt agcacacgac gagctacatt accagcaatt gctacgttat 34740 aagcagctgg atttaaatca tgtaaagctg ccaaaacctt tacgtgcttc tcacgctttg 34800 acagtccttt tctgttatgc ttatcaaatt caccggctac aaacatcttt aattcattct 34860 tattcattat cttttcctct attttggact gggctcaaag agtatctcaa aatctccctg 34920 aacccattat acaacaatta ttcctcaagc attataactt tgcttgggcg cttatagaaa 34980 gcatgagttt tatcatcttt cgctaattca aatgtagcag taaactgtac tttgcctctg 35040 tattcaaacg gaatactttt tggaagggag ccgtaaaccg tagctccatt ctcaagtaca 35100 accatcatct tacattgtac gccgtaatag tcttcataaa cttttactga cgttacggta 35160 ccggagacag tcactcgtcc ttctggtgca tcccctttat tcttattcag ctcattaaat 35220 atattatcaa agacctgttt tgaatgttcc tggatagcct ctaagatgct cttatgggct 35280 ctaacttctg ccataacaac atctgttccg tcttgcaatt tccactcttt atatggaacg 35340 cgtacttcaa gaggataacc atactcacga agttctttgt actccgcttg agttaagcgg 35400 agtttccacc aaccgtggtc acctgtatac tcaggcttat ccagcgaatc caattctgta 35460 acatacggca agtaactgcc tgcgtgataa gcttcaactt cacctaattc attttcccaa 35520 agataaccat caaagggagc atgaggacga tcatctttgc cccaagtagg agctacaact 35580 ttatcaaagt attcacgacc gaagcgggtc ttcgcccatc cagcattcaa ctcctcggcg 35640 cgtttttcaa ctttcgctcg gtgtgcttgg cgggctacac gattttcttc aacaagtgca 35700 gagataatct cggttaaagt tttcatttta ttctccagtt tggttgacga gaccatctta 35760 tcaacagcct cgccgaaagt aaactacttt gtgaaaaatt ttctccaaag cagaactgcg 35820 tctctacgag atacttctac tgctcctaga gcaactgctt gcttgcgacg aacatcgcgc 35880 aaatcatagt gtggaactcg cttatcctgg aaccaagaac gtttcattcc gatagcttct 35940 gccatagcat gcaactcatc aaggttgtcg ctaaacatat gacaattctt tacttgatga 36000 cctctcattt tccagccatg attcatcaag acatctacgt atactgtcat ttctgattct 36060 cgatgtaagt ttcaatgatg aactgtgcta aacacagaag attatcttct gacggagaat 36120 ctactaaatt ctcaaccatt tcagaaatag ttccaaaagc ttcttcagta ttgaacattt 36180 cttgaagttc gttccaagta ggtgctttca tttcaatctc ctcattagtt aacgaagcta 36240 tcttatcatg gcttttctaa gatgtaaaca acaaaagggc ccgaaggccc ttaaaaagat 36300 cggaaatcac tgttaaacca tggcgactgg tgttgtcgcc gcttaagcaa tttcagttgg 36360 tatttcctat tgtcttctat aatcatctta gaggctttta gctcttcagc caatgagacc 36420 tgtttacggt ccatcaagat gaggttctgg gtcttctggg caaacgtctg aatacctttg 36480 agacattcca cagattcctc catccctcgt ttatacttgg ttcgggcagc atttaactgc 36540 ccttcgtaat acgcatgtat agacactata gtactaaaca ccttttacct caataacatc 36600 taagataata tcttcaacgt cttgctcagg gaatgccacg ccattggtct gcccatgctg 36660 aaatactgct tggtacgctg acggtgcaga aattcgggtt gaacgttctt tattgtcata 36720 gcatttgcca tcaataaagc gtttaaattt aacttcatag gtttttaaca ttattacacc 36780 ttagcataat tgacaatttg ttcacgatca gcgggccaat ttaaatcaga acgtttcttg 36840 tttgaccacg caatattttc ttcagcccaa tgaagtttag ccgatacgct cttttggact 36900 tctctgattg cttcttcaag ataaatgcct aaatctctcg ggttagttcc ttgagtttta 36960 aatgcattga gcaaaatatt tcttacaact tctttaaatt gattttcaac ttccggatga 37020 atgaattcac gataaccgtt gcacggatat ccaaaagcat ctaccatacg agcagtacta 37080 aattctttgt tcataatccg agagcctcgc gttcatcagg atttaattta gccaaagcgg 37140 cttctttaat tttttccaac cgtttacgct tagcttcagg tgtttcttcc tggacgatga 37200 tagcagcctt tttagggaat gtccatgatt cgccattttc atcggtgaat gtaattagtt 37260 ccgttggctt acgattaact gtaccatctg agccccacca agactgcccc ttaacggctt 37320 cttcggcaac gcaatatgaa ccataataac caaacaactc actacggcga tcgtctggtg 37380 aaacatacgc tgcataggct tcactttctg tcattaccca tttcatttta gcacctcata 37440 acgaataagt tcaatacgat ttttaagctc ttggtatgat ttacgccaag gcttataata 37500 agcatttaaa tcttgatgct gtttatgcat ttcgtctaaa tgctttactg catcctgtac 37560 atttacaagg aaagtatcaa atactttgtt agcgtattct ttcctgagct caatgaatgg 37620 aggagcacga aatacgttta ccattacacg tagttcatga taagaagaat ggacttcagc 37680 taatacattt ttcttatcgc caaaattaaa cttataaagt ttttcacaga ttgcttcaca 37740 ggctttctct gctttaccct tgggtttacc cgcaaagata tgaccaggcg gatatacttt 37800 aatatcgttt aaccaacatt caatatcttt aatagctgct aaactcattg tacccacgct 37860 ccattttcat caatgtaatt aatccactcg ttaatagtcc aggaagaggt atcaccttta 37920 ggagtatcaa cgatatacat tccgccttta aacaaaacac gttttacatc attagaaatt 37980 aaagtagcca ttatattttc ctcagttagg gaggatttct cctcccgttt aaattatttc 38040 agcattgtta cttcagcaat ttcacgccag tttttacggt cagtcgcgac gaaatcacca 38100 atataaagag cagtacggag agatacgtta cgcagacgat ttacgttatc tttcataaat 38160 tccaaaactt caataacttc agaatttctt aacccacggt tctgtagcat agaagtagtc 38220 attattacat cttgaactcg gaccataatc tcttcattag tgtgaacacc aaggtcaaga 38280 taaaccgaac gtgataccag agcttgaaga tgcggagcaa gtttagaacc gcgctctaat 38340 tcacggtcaa tatcaacgtt agtgataaag accacagtac cttcaaactc aaactcatta 38400 ggaattcctt tatcctccaa gaaagaagat gcagtgctcc agcatacttt acgtttctct 38460 cctgaatcca aagcagcttt cagaaggtta agaatgtcca tatcagagaa tacatccaca 38520 tcatcaatca gaagaactga atttgcttca cgtgattccc agagacggca gtacaaacca 38580 attcctgaga ttttaccatt cactgattta taatcaatag agttagtatc atgagcatgt 38640 tgtaatgctt tgtccaaaga gtaagtctta ccgatacctg ctgctccgga gataatcaga 38700 gaacgaatat tcccatgaat taaaccgtta gtcattaatc ccatgacgtt aaagcgtttc 38760 ttgatacgct ctttcatttc atcaacggat tcaacaactt caattttagc agctacaccg 38820 tcaactgtaa tatcatcttt gaatacccaa acaccacgct ttttgccatt cagttcaaca 38880 aagactttac catcaccctg gcgagaatct tcagcactta agctatccgg gaaccactca 38940 ccgagtaact cataagtacc tgaaatctct ttgccgaagt aaatcccttt cttgatggtg 39000 atagttgaca ttttattctc cgttactctg ttttgttttg atggagctat agtatcattc 39060 tacagctcca aagtaaacta ctttttaatt atttttctaa aatttcattg atgtagtaag 39120 gacggacttt tgaaccaaga tagaagtcat ctacaaaatc aatcaagttg tcagtttcac 39180 cacggatgat agcaagttta gagaacgctt ctcctaccat cattggttca aattctacgc 39240 cgtgagcttc agcagcttta aaggctttat caatgttgtt tacgacgatt tctaaagttt 39300 tcattttatt ctccgttatc tgtttgggtg gtacaggtct atagtatcac cagctcgcga 39360 gcttgtatac tactttatgt attcttttga aacaaaaaga ggagcccgaa ggctcctcag 39420 ttatgcgtgc ttgttgatag cattttctgc gatacgcttt ggaagtttac ctgcccagcg 39480 gaagaacatg ataatcgctc cggcaataaa cgcagggaac caaaagatga gataaaacca 39540 atactctcct gctttctcga tggttccatt tttgattaga tgcttacaaa cagaccaacc 39600 cacgacaaag taaattattg caacaacgat tggcactact acgctccaca gtaaaatcat 39660 atttcagccc agtaaagtga gaaccgaaga gtttctccgg cccatgacat aaatcggtgg 39720 atttgttttc gagttggtcg agcagagaat ttagcatttt ctctacgacc agtctctctg 39780 caaactgctt ccaaatacca ccgtctacct ttatgaggtc ttccgtaatt caagaagacc 39840 ttcattgtat catttgtagt aagaattgtg gttttcaaga taaaccttct cgacgaaatc 39900 gtcccagaac ttcatgtcta ctttcttagg cattccattc ttttcggctt gatgagcaag 39960 ccgctctact gcgtcaacgg tcgtttccaa aatatcctga acttctttga acggtaactc 40020 accagctttg attttcttaa tcaagggagc ctgtgtcaga ggatatttaa ggtcaccgga 40080 agaataaatc tcctgtagct gaagaccacc acgaagggca tgacttagtg ctttccaatc 40140 tacaccttcg ttagcttctg ccttacgagc gcgttcgcca tattcagcat caagcttctc 40200 aagggagtac ttcatttcct taactgtgat agttgtctgg aatttacgac ctaacacatt 40260 atagaaatac tgctgacctg atttatggtc tgtaaaggtt gtccactcaa ggaattcacc 40320 taccggaaga cgatcggcga tgtccttaac tttccaacga tcgttaatgc ctttctgctt 40380 aggacgatcg tcatatttcc attcaggaac atctcggata acatccagga ctttatgcaa 40440 atcagctaaa cgagaaccct taacgccata cttaccagcc tgcttacgga catatccaag 40500 ataagccttc atgtccgtgg tatagaaacg agctcggttg tcttgaatga atttccatac 40560 ttcaggaagg tcagatgcaa ctaccaattc cggcggagta tgcagcatgt caagtgcaac 40620 tgtttcaccg tcagcagcga gtttgaagaa gtatttcaaa ctgaacagct catggtcaat 40680 atcgtctttg gtatttttgg ttgcactgtt attcgtatta cggttagtat gattcatcgc 40740 ctgacacatt agaatatcac gcggatgagg aacaaagatt tctttgaaat ccacatctga 40800 ttcaggagtt gaagtaccat acagatgcga accaaaataa gattttacga ttgttttcat 40860 aagtagatat gattcccttt agcgaattta actaatgcat tagaacgctt gacggcttct 40920 tctgctcgaa ctttatcagt agttcttttt gatgtacggt aaacattacc aattttttga 40980 ctagtgtaat aatacactac ttcatgtgta tggtactctt gtccatcagg atgctgctca 41040 cgacaggttt cttcacgcag tgtggtttca tacataggaa ctaatgccca atcaattcct 41100 gtgctaatga ttgccacctg gatgtcaagt ctgttccagc gaaacgcatt gatatatcct 41160 aggacccgtg attctgggtc catcattgcg aatttaatgt tttcggctga agccagaggc 41220 atctgtttta caatactcat actaagtttt ttcttagtag ttacgatttc aatttccata 41280 ccccgccttc ataatatatg tctaaatcaa tattatcttt gccgctgtac ttgccagtca 41340 aaggaataaa tttaacagta atcttttcgc cgtcatcaaa agtaaattca gcaataggat 41400 atgtagaaat tataccacgt tcggttttag cacgaaagac ggcccgaagg ccgttcacga 41460 tataaacttg atcattcttc actaggttca cctactgtaa tatctagcat tgatttaaca 41520 agcgagatgt catttgtact aaacacgtga gcttttcctt tatcgttctg gcaaaacatg 41580 cttccatctg ctgcaattgc tagtacttca tagcagttat tagttgtaga gaatttatca 41640 cccactacaa gaggaacatt aactttacac ttctcataaa ctgtgtattt aaggctgctg 41700 agattaatta ccgacttaga actacccggt aaaagtttgc agatataaaa tccatcgtct 41760 gcggattcat ttaggtaatc atcgatatac attccacggt agccgtcttt tggatatact 41820 acagtagttg tttctcggct gctatggtcg taatatacta cgattttggt gtctttactt 41880 ttaaagaaaa tcgatactgt atgcgctgag ctacatttga acgtagaaat aaattcaact 41940 tcaagctcaa gccgattgct ttggttatca aacccaattt ctactttatc acctaccttt 42000 aacggctttt caacaaggct ttcttcaaat ttcgtgcgaa taaaacgttt catttatcac 42060 cttctacata atcaatcatt gggcagactt tctgcttacg agcttttaaa tactggatga 42120 acaccaaagg ttcggcttct gccggaagac cagcttttac ccgagcgagt ttcttggtat 42180 actttttctg gatacggtaa tgtttaaatt tttctaaacc aaaaataaat ccaaaagcta 42240 tagctgcaaa caaaagcata aatgctgcta taaccgctgc gccaactggt actgctataa 42300 catttaacca aaacgcggat aaactaatac ccatccaagc gagaattcct gtctctgcca 42360 caatcggcca accgaacatc catgcaacag aaccgatgaa tgtaataatc gctgaagaaa 42420 acacaacatg aagaactgtt gtccagaagt atccgcacag tgtttttggc attttccaca 42480 tgttgtcaga tttaaaccac aggttcattt tgaaatgcca agagttttta ttaatattca 42540 ttatcagtcc ttcatagtcg gaatcatagt tacaagatat tttacgagct gttcagcatc 42600 ggatttatca atcatcaaga tagtaccgtt gcgctcaatt tcaataagtg tagaaccgta 42660 tagatctacg gtagtcagat gcaaatcatt aatgtatgga ctttcgtcct caattactgc 42720 atcgccttta cgggattttc cgtcccatac taatttactc gccatctttt gcctctatca 42780 agaattgaat taatgaatca atttgtttag tatcaagatg aattatatca ttgccttgtt 42840 ttagcacgat acgactcaac tttttagtga aatacgaatt cacaaccttt gcatgcacat 42900 cgctgtatgg attatctaaa ttggtactat caagaatact ttccataatt acctcaattg 42960 tgaatctttt gaaccacgac gattataagc agaagtcatt acactgtccc actttccttg 43020 acattctaca caccgttgac agcctttaac aagaaggcga cgagctattg gaatttcctc 43080 atcacagtca acgcaaaact cttcggattc acgttgttct tgaagctgtt tctgtagacg 43140 ggcccattca atcccgtctg ctatagtggc ttcacgagtt gcgaagccat catccgatgg 43200 accccatccg ttcatttcaa actcgctata attaaatcaa gcaaatcgtt aacaaagttg 43260 taagtaaaca tcggatattg atattgaact accatgtata aaataatcaa gatgtttttc 43320 attcttcgcc atcatcaaag tcgtagtagt cgtaatcaca ggaatcaaga taagaatcca 43380 tgaattcttt ctgccgacga aaatcctcaa taggagtcag tctgtctgca tacgcttggt 43440 catctgggtc actgaacttg tcttcttgca gttctttaat gaactgttca gcttcttcac 43500 gcgtccaaaa cccacgatta agattatgaa ccgaacgttt ttcacctggc ttgaatacgc 43560 ccatatcatg agcagaacgc tcagttgaat aactttcagt ttggccagca tagttttcat 43620 attcgcaaat cacctggaag aaaggagatt ttcgcgaata tacaccacga agaccaagtt 43680 caacatcata cgtgcctgat gcaacaatgt aacgcgaaat agaaccagac ttggtttcag 43740 tgcgattaac accacacacg tgataaaaga tttttccagg ttgaagctcg gtagttaact 43800 taatcataat gtttttctcg tttggttgtt gatatgtcta tagtatcatg taatgaaggg 43860 aagtaaacaa ctttttgaaa agaaaatgcc tcccgaagga ggcggagggt attactgcaa 43920 tgataacaaa tacttagtct tgtagcatag acctgtaatg tcatccagaa cactttggag 43980 ggcggcagga actgacttgt agataccatc ggccttagcc agaatgaggt ctagcatttc 44040 aatggtgtcc tttggcagct ctttctgtga tggtaaagcc ggtgtataac tcttacctga 44100 gaatcctaac cactgctcac caaaagcatc tatcaaatct ggaatctcgt taaagaaaac 44160 ttcatacgct ttatgtctgg catacgattt ggtatcaaaa tgcgctgaat gaaaatacgc 44220 ctgagacgcc ataagtaaac cgatgaattc atcttgtgga gtaagtttac cgtcctttac 44280 aaaatcattg aacttcatta tcgagttgta tcctcatgcg gttagcatat tcttcacctg 44340 ctgaacgccc taaagaatcg caatctttag aacaagactc gctcttccat ttactttgta 44400 tgaaagaata gaactgttca gactcttgct tactaggctc cttaaattta gcataaactt 44460 gtagagctcc ctcaacatac gagttataat ccgaaatgtc gtcgtgtgat gcagctggga 44520 atgaaatccc gcagcccaac accagggcta agcaaatgtg attaaaggcc atacggcctc 44580 ctattatttt tgtccagtat tacgtttatg ctgtaaaaca gccttaactg caacgaggta 44640 tctttcgtga gaacgcatac gcttatagtc cgcttcagaa tcagtttctt tataagaaat 44700 acgaagtgct gaaataatgt gcccaacctc aagtcgaatt tcgtctaatt gagaaatggt 44760 caaattacgg agttgcttat gtgacaaatg ctgcatatac acctcatcag ttagtaatag 44820 tatttatata agtatgtgtt acttaatccc aaagccattc gcagatgcct tgctcaatag 44880 ttctagcacc agcttcgtcc cagttatatt cttcgtcata cttcaatgcg cgtttaattt 44940 cggctttatg aaatagacgt gggatcggca tagcataacg ggtccaacgt agagttttcc 45000 agaatccatc acgctttgat ttagcaatca gtttcttggc ctctagcggt ctttcccgat 45060 tttcagaaat acgcagttca acatatttct gttgggtttc tttatctttc tgagttttaa 45120 cgtattcgtt atagctttta atataagcaa attcgttatt attctgatcg ttccatttgg 45180 aagattttac tacatgccag cctttacggc gaattgttct agacattatt acctcgttaa 45240 gttaaagtac ctcaacgata gtaaaatcct gatttaaaaa atttaatatt catgaataga 45300 ttaccttaca tttacatttg gggcattcag gttctttggt tttaagacgc ttggtagctg 45360 tctttggagc agtgttgtaa tcatatacat gaagacaacg gtagcacatc acatattttt 45420 tcatattaaa ccatcaacga aagcaatatt acgtacagca agaatccaat tatgagtact 45480 agtactatac cacttgctat ggcaaataag ctactcatgt ttaatataac acccattcat 45540 attagcaata aagtctttac cttgtgctaa tactttacag ctagaatcaa gacgattttg 45600 tgcttcttct cgtctgtcgc tttgcacaga cgctgctgca gcaatccaaa tgaatagcat 45660 acctacgatt agcatcagga tagtgttata cgttcttggc ttcattataa acaccaatta 45720 gttcaaacca atgcttacgg caaagagaaa catacttatc ttcaccacca agttctacta 45780 cttcaccatc ggtaatggca tttccgtttt catcaatacg agcaaccata gtagctttac 45840 ggccgcaatg gcaaacaccc ttaagctcga ccagtttatc agccacggcc aaaagtgctt 45900 tagagccttc gaataactct ccgcgaaaat cagtgcgaag accatatgcc attaccggaa 45960 catcatataa gtcaacaatc ttacacagtt gaacaacatg tgcagtagtt aaaaattggg 46020 cttcatcaac gaacacacaa tgaatatcac gttgtgtttg tgcccacttg aaaaactcaa 46080 ggatatcaat agattcgtct actgtattag cttcatgacg aagaccaata cgtgatgtta 46140 cctcggtggc agaatctcga gtatcaatag caggtttaag aatgagagtt cccattcctc 46200 gttctttgta attatgcgcc gcggtaagaa gattagctga tttgcctgca ttcatgctcg 46260 cgtagttgaa ataaagctgt gccattaaag tgtctccata aaatcagaaa tagcattctt 46320 agaacgaatg agttcatcgt attcttcagg tagaccattt ccataaatgg cactaatagc 46380 tactacttgc tcggcacctg cataatcgtc aatcaactgc catagtttag ttttttgctc 46440 ttcagtaatc atctatttac ctctaacaag acggatttag cttttagctt cttcatattc 46500 taccaccata atgtcaatat caggtgttgc taaattgatt aatttctcaa ttagttccca 46560 atcaccgcca gcaataccag ctccaatttt tggaatgtac agaggacgat tataaacaat 46620 acgaccagaa tttagttcat ggaatgcatt aaaaattgcg ccgtaatcaa cgtttggacc 46680 tggagcatac tgagtgtata gattatagca atatgcagtg ccttttttgt gaatggctcg 46740 agtatgagtt ccaagcttag ctaaattgtt gtcataataa cggtcttcat cgatgtcaat 46800 atcgagaatt ggaggatatg ctttagcaag ctgtcctgct acgccggcac ccattgtagt 46860 aaagcaatta cacccatgag cgatatcgca ttcatgcttc atgaatagtt ctacaatatt 46920 gcccttaata tatccagtaa tcatttattc acctatggaa ttttatatgt tgcatattca 46980 ttaagattat tgtatactct taaaaatata gcattgttac aattaaggat agggttcagc 47040 actccttgtt ctttaggatg cattactcca tcaacagaaa caccgtcact ctgcattccg 47100 catccgcgag cattatactc aacatgtgga actatcactt ggtcatcttt atcttgataa 47160 ttataaaatg acattagcag ttttctacta ctaggcacaa atgctatttc aatattgttc 47220 ttgaatggac cgttgctttc tattttagtc ccctgcgccg ctagtacagg ttcaggatag 47280 cctgggagct tttcccaggc attaactgaa aatgcacagc ataataaaat agctgctttt 47340 ttcattttga cgatagtcct gacatataac gagccattaa ttggtcacga tacattaaac 47400 atatattttc gttaggagca ttgacacata aatctttcat gctcttagcc ttacgattta 47460 ttagtgttgt ccactgagcc gggctgcgtg aatcttttac tccatcgctg aatgctgaat 47520 ctaattcaag cgctaatata tcaacacatt cagaattcgt attacaaaat gttttagcaa 47580 tacgaagtga atccgacatt gaattttcag cattaacaga gaatgccaat actaatccaa 47640 gaagcgcggc gtactttatc attattccac ctttatatgt agcattttat gtttctttaa 47700 gaaatgagct ttctctagga catctgacgc ataagagttt cctcttttga cattccatcc 47760 tgcgttataa ctagcaagag cttttcgcat attgccgtta tgtatattta accaatatga 47820 aagctcaata tatgcccact ccgcagaatt ccgtctggat ttaagcattt ttcttatttc 47880 agaatcacta aggtttttac cttccagttt agctctggct ttaaccgtag gcaagtaatt 47940 ttgaaatacc ccataagaat gatgcccctt tcctgctttt aaattggctc ctgccgaaga 48000 ttctttccat gatatagcag ccattatata tcccaagccg ttattatcgt atcggttatg 48060 cggagatttt tcctttccgg atttttgata ttgttcacca aaattatatg cgtaatgcaa 48120 gttgtcaagt tgaacattac tgaaagttgg ctcagaccca aaggccgttg aacacaaggc 48180 cattagaccg ataagcgctt ttttcatgtt tacctcaatt aatatgtata acttttgtgc 48240 tgattttacc tttcaaacgt ttatcattaa cgaatgccat acgacacttt atactaggtc 48300 cttttcctgg tcttggaata tccatggtaa atcctagcca cagatttcca tccgtaattt 48360 ctaaccgcat gggtttatac tcgatatttt catcaatgtc ttttgggtca attggaagcc 48420 aaggcattgc taaaaattca ttaatttctt taagatgatt aggaattttg gaaagaacag 48480 agaatacata ctcttcatca atttcacgtt ggatagcacg gtccaacaaa tgatcagagt 48540 acttagtgaa gaaaggctct ttgccctcag ccttagctcg ggcacgaact gataaattca 48600 aagagcgaaa agcttcctca aacttacgac gcagtttagt tctgcgaatg aatacttctg 48660 ggttagttga catagttcat tctcctttat ttgtagggcc atagtatcat ggcccgtaag 48720 gaaagtaaac tactttttaa tatttttctt ctggacagaa cactgcacgg caagcccaca 48780 tagaagcttc cttcagtttc tgttttgctg tacgaatctg ggcaatacgt tcgtatgctt 48840 catcgagtac ctgcttgggt tcattgactg acacttggta attaattaat gcctcttctt 48900 caagagcagt aaagataaga ccaagacgag tctcagcgtc tttgatagca ttcactttac 48960 caattttttc attggtatgt ggcttgtatc ctttaatatc ttcgattgac attatagtgc 49020 ctctgtgaaa gtacgagcga taacgtcgcg ctgctgttcc ggagtcaggg agttgaagcg 49080 tacagcgtag ccggaaacac gaatggtcag ctgcggatat ttttccggat gctcaaccgc 49140 gtccagcagg gtttcgcgac gcagcacgtt aacgttaagg tgctgaccgc cttcaatttt 49200 taccgctggc tggtattcaa tttctacttc acgcgccttg tagccataaa aagtttcagc 49260 atcagtaata gtatcttctt taagaacttt tgaaacgatt actcgtgcgt catcgccatc 49320 ttcgatgtaa atggtgcctt taagttcacc ttcaagaatt tgatatgctt tcatatttcc 49380 tcttaattag attctttatt ccaaccatgc atgtatgcgg taattacact cattttattc 49440 cattcgtctg aatgaaactt tgcagctgct tctagataag ttattttatc ttcatgataa 49500 gtaacttctt catcagtttc tttatcgtac tctacaattt caataggctc gtcaatacca 49560 tatccacgag tgcctatata cgttgcagct tcttcccact gttttgtggt ttcattccaa 49620 gttccattct gatgggcttc atagaaatct tgctcgccag aattactgaa ccaatcgcag 49680 aagctttcaa ctaaatgtgg aggacacttt ataacaattt cagccattgc agtgttttct 49740 cttgaatgcg ttggtcatat gtgattaagc ttgaactaat cacgcctttg agcttgccag 49800 atataaactc aattctaaaa ttaggatagc gattcatcca cttcgtgtta ggagcattag 49860 aaatgaattc tgcgcctttg aacgggccag acagaaactt gtagcgcttg tactcaagca 49920 ggttgccagc cgtaaccatt gttattaatt gcttcatatc ggcaaatcct gtattttcca 49980 tcactgtaat catatcaaca atttctgtct gtgtcatcat tgcattccta tcacgaaaaa 50040 taaaggtaag gtatcattag gcatagacca tctgatagct tcctggtaca tatcatagaa 50100 cttcatcata tcgggaactt tcattggttc ttcaatgata attaatgctc ttccaaactt 50160 tcttccccta aacttgtaag aggaatcatt ggatagaaat tccctgattg tcatcggaac 50220 aattgattta gctatctcgt tagccggtaa tttattaatt aaatgtgatg aattatattc 50280 tcgtagaata ccttccatca attcagatga ttgtgtgtat cgagtagata agattataac 50340 cgaaccatct tcaagcaacc aatcggtagc gaattgacat aaggctgcag tctttccggt 50400 ttgtcttcca ccgtctagac gaagggtacc gtactctcgc ataaggcaag acggttcata 50460 aaaactgtag ttgggattat tcaatcgtct gtctgcagcg tctctgaaag catgcatcag 50520 ggtcaaataa atgggagtta agtgtttcat tttagattcc agttaaaggg gccattcctt 50580 ggcacatgtt taatccatcg acacactatg taaacccctt accgcacttg ggctcgacct 50640 tattacaggt aggaaaagct acttcactca gaggactcga cgttcatgag gagaggtcgt 50700 gttcggcttt attaggaaat tgcttactta attgatttag cgtaacgaat agcgccacga 50760 tcgtttacga acgcaatctt gccattacgc atgtacatag taacagtacg ttggtaaccg 50820 ttagaagttt taccagactg ataacctact aatgcaaagt tatcttcacc aggtttgttc 50880 tgcttagact taatacgctc atgaccaagt gccattaagg agcgtgcatc gccagatgct 50940 actgctttgc gagaagactc atcttcaatt gaagaggtga aatcatcgaa tgaatcaaac 51000 ttagcatggc tcttattata taacttgccg tctactacgt agttatatcc aacaacgtcc 51060 atttcaattt ctgtaccatc ttctaacgtg gcggtcatct tctgaccttt tttaaatttc 51120 agaagattac ttccaacaga ttcagtcatt acgccaactg ttgctaaacg ggattcattt 51180 aaaaattctt gataagtttt catttatttt ccttgataag cggcccaagt tccggtccgc 51240 atagtttcaa ttacacgacg agcacgatta ggtgtctgac gataccaacg tgaatttgcc 51300 agttctttgg cagcagcatc ccatttttta gcagctaaga gcttcatgga agcagggaat 51360 ccagcgacac cacctacacc catttggaat accatgttaa ttagagctgc tctacgaaca 51420 tcatctaata tattatatac cggacttaat gtagcattag ctacaatgcc cttaattgct 51480 ttttctacat cctgtgcaaa aattacttct gcctcagcct gggtaatttg gccaccagta 51540 gaacgaccta caagcttgtc caggttagaa atagccaaag attttgacgg gtctttagtc 51600 agtaagtggc caataccaat agtccaatac ccttcggtat ctttataaat tttgctatcg 51660 tatccttcat caatacgcag catgccaaaa atatccataa ggacctccta ttaattatag 51720 gagtatttat ttggccctgc acttggctat gaataattca aggctacact tctcgtatgg 51780 tgtccattta cctttccacc acacataatc tcttctatcg tcctcgggca attcactaaa 51840 tcccggatat agattttctg ctatgtaata tgctgatttt gtatactcgc cgtcaccgaa 51900 gacgtatcgt gatttcatta gtatacgcga cattttatcc ctaggatgaa atatgctaat 51960 ccattttcca tcgtgaataa atcgtagctc atgcttataa atgtgtggaa tgcctaattc 52020 aacggcttct tccataataa cctcactgag ctgtgctata catttgtgtc atgattttat 52080 acaaacttgg tcccatcgca tatttccatt gagaaggttt aattaaagca aatgcgtcga 52140 tttccgggaa aggaattcca ttttcatctt tatggtaagc tgtgcaacgg caatttctga 52200 acatttctgg gctcacaggg agcatatatc caaacagatg gatatcctta ttgctggcat 52260 aatcatgtcg tccaaggtca tataagaggt cctggtcaaa ctcagtaaat ccagtctctt 52320 ccttgcattc gcgaatagca gcctcttttg gagtttcacc aggctcaaca tgacctttcg 52380 gaatatccca tctagagcct ctgccctgga catatgtatt tgtcatacga cccatgaaaa 52440 gccgtttgtc atcggtaaag aataagattc ctgcactgag ctctttcatt ggcattcatt 52500 ccaactttct tcaagaatat cttccatggc agtatagacc atagactcta gtacaccatc 52560 acaattatat gaaccctcta ctgagaaatc acagataggt ccattaatac caagcagttc 52620 ttctttaagt gaaatctcga taccgctcag tgattcgtta tcactgtaac acagaaggcg 52680 agtatcacca ttttcaaatt ttacatgcac tgcaacagcc attatttcat ctccttaatc 52740 caggataaag tttcattacg agaatcatct ttagattttt ctttctttac tttgggctta 52800 tcaaatacac cccgctgtcg ctgggaaacg aattgcaacc aacgagcaag cattgcaaac 52860 caagttccaa cacctgacat ccaacctaaa tagaacaaag tatctccaaa gattggtgaa 52920 aagaagtaaa aaccccaaaa agtcccaaat ccaacaaaag ctgaaaatga aaaccagata 52980 agcagaaata ggaaaaaata cccaggctca tcgtctttaa tcattccacg ataacaagtt 53040 ttaatcattt tctgcagctc ctaatccagg tgttgaaatc ttctttttct ttccacttct 53100 tgtatttcat acggtaagct aaaaatgtgc agcaattaat caacgcgata attagcatcc 53160 acatgaggct gaatgcgaaa acacctaaaa acaaaagcat aatcataaac tctgagacgt 53220 tcaatccaaa gaatgcccct ccaacaatta caaaagcaca atataaaatc catgtcacga 53280 ttccaaaagc tggcgccagc ccatcttggt tccaaaaccc gtcaggttta cattcattca 53340 ttttcttctc acctctttaa taaactcaaa cgactttttg cgattccatt caagagttaa 53400 attcttgcac tgttctttcc attcggcctt tcgttcacag ttatgcttaa catactttac 53460 ccaacgaaat agttcaatta atcctagacc aagtaaacct attaatcccc atgtaagtaa 53520 tattacattc actaatgatg tactgctaat ttcagccaaa ttcattacgt cgattatgat 53580 aagtgttatc atagttccag cagcacagac catccccgga attagaacat aatcagtttg 53640 gtcaaattta tagacataat tataaacggg aggttcactt ggcagatata agttactcat 53700 ttctgcaccc tctcacggca gtatttgata aattcatcaa tgattaattg tttgcctacc 53760 atgttgttag agtcaaacat acccatgact tttggtggca attcattaac acagtaattt 53820 aaataattgc tataatcatc ctgagatgtc acgtatttaa ccaggttaat accgagacga 53880 taactagttt tattatagat aatctcaata actactgtat atgttgtgga gctagaggta 53940 aaatacccat cagcattagc acgggctgat gttagatttg acggagaatc attgaaagaa 54000 taaattccgt accgaagtgc aaagatatct acaagcttaa ctccatcgga aatagacgaa 54060 atattagaaa ttaagttttt cagcttgtag tagtctttaa gaacgatagc ccgcggcaaa 54120 actgtggtgt tatacccgtt atagcgagtt ttccaatttt caggccgagt atcaggataa 54180 gcaaatttct caagaatatc agtgatttct gttgggaatc ctgctgcaat taattcttta 54240 atttgaggtg ttgccattgg aatatctcca gcgcattcat ataacatttt attatccaag 54300 ttaggggccc gaaggccccg gtaaaattac ttcagacttt ccagatattc ctggacatca 54360 gcagtggtgg tttcaatacc aggctgagta ccgctgaagg tttcaacttt catcatgatg 54420 tcttgtacat ctactttagc gagttccgcg atttcaatca cgtcatcagc agaggtaata 54480 cccagagcag aagcattacg ggtctcacgg atgtattcga gtttcactgc caaatcaaga 54540 cgctggtcat caagcttaac tacagtttct tcaatttggg cccgcatttc tttatattcg 54600 gcagctttat cacgtaaagc cttagcagta cgacgataca gaagacccag tttagcatgg 54660 gtttctacat tcataccttc tgccatcaag cgacgaattt cgcgctcttt ggaagcacct 54720 gcctggtctt tttcgtcagc aagtttcagc agacgctttt cttcatttac tgatttaaca 54780 tgcgtggtac gcagtttagt gatttcatca ataatacgat ttgctgcagt ggtgtactgg 54840 tcttcaacag aagtgttctg tgcaacgaag gtaccgaatt tagaacggat gaattcaacg 54900 agttttttca gaatagacat tttatttcct ttcaatagtt atggtggttt tattcgtacg 54960 gattaatcca atcataaaca tatggtttaa tgattagacc ctgttcattt ttgctgcgct 55020 cgaatatctc gatgtaatca gtaacgtatg attctaatcc gagaataagt acagactctt 55080 tgccttcttc tactgttgct ttaattaaac gctcgatggc tattttagct tcaagacgaa 55140 tatcagcaag ggtttttgga acttcatttg tatgcattaa tgagttcctc cattttgtcc 55200 aaaactgcga tatcaacaag acgattaacc gccgggtcat cggcaaactc attgtaagtt 55260 gaaatcacca ggttctcaat agttttcaga gcagccattc gttcttcacc ggatggaaaa 55320 tttggagttt caccaaacag cctagcaaaa gatttaaaat aagtttgcgc tactaatctc 55380 aacttatcct gatacatatc aatttcctca gtaggtggga gttcattata actccccaaa 55440 attattagca gttaattacc gcttcaattc gtttaaccaa agcagaaacg gttttagcaa 55500 acttgatagc catttgaacc gtagcagctt cttcatggta aactcgaacg tagtactctt 55560 caacagcagg ccaatctttg cgaacatgct taatcaaatc tttcagttca cgagtttctg 55620 ctacgttgaa cactgcattc tcatgttcac ctttaatcca aaccgcacga taacggtcag 55680 gagtaccgta ttgattataa ccacgttcaa tttggataaa gttgaattta gacattttat 55740 tctccgttac tctgttttgt ttcgatgtag ctatagtaac cgagttgact ggcgttgtaa 55800 acaactttgt gcacaaattt ttcaaataat tttagggaat ctggaaggac tttatggagg 55860 gtagaatgga tttatacagc ttggtatata gaaatgccca gacgacctct agaaggcatc 55920 tgggctataa attacagttt cttataatgg cgaccaacat caccaacgta gtgcgtcagt 55980 tgcttcaaac gattaccgaa atcttctgtt ttagaactag tgcttaaacc atacagtact 56040 gcatataaat caggggtatc acgtacgtta actttagatg cgattgacgg gtcaacagat 56100 gcaactactt ttgcatggag tttagcagat aatgccgcag ctttttcgta tgcagtgtga 56160 acatcagccc atgctttatt cagtgcttta acatcagcgt cgctaagaac agatgacttt 56220 ttagcagctt taggtttagc agcgcctggc tttggtttag taaaaatttc accagttaca 56280 accattgatt tccatgcgtt tgtaacatcg ttgccgcgga atccaagttc tttcatatca 56340 cgtgcgaatt ggaatcgtga ttcatcggaa gtatctttgt atgagtattt tccagcttcc 56400 atagctgata tagccgcagc tttaacatca gaagaagctt ctgccaaaaa ttctttaaat 56460 ttcattataa attcctttag taatagtgtc gatttctatg atatttatac taaaaagccc 56520 cgtccgaaga cggggctatg aaaatcgaca gcatcaccta ctggcagatg acctgctaaa 56580 ttcattcctt tggactcgga ggcatcagtc tcatccaaag aagtatagcg tcaggaggtt 56640 atgcttgcga cagggaacaa ccgactagcg gtaatggacg aaccattctc ttctatctga 56700 cgactcaacg agggcatacg caagtttccc ttcgaatttg gtgccgattg caggagtcga 56760 acccgcgaca tcttcattac aagtgaagcg ctctaccagc tgagctaaat cggcttggtg 56820 caccgagagg gattcgaacc ctcaatcctt gcggcgggag attttaagtc tcctgtgtat 56880 accagttcca ccatcgatgc gaaatggtcg aggcagaagg attcgaacct tcgacctgcg 56940 gattagaagt ccgctgctct atccagctga gctatgcccc gagattgttc aggcaggact 57000 cgaacctgca cgactgattc cgtcggcgat ttaccaccat cgccagcata tgatgcaata 57060 tgcgagctca aaaggtgtcc gtcaccatgt ctaccgattt caacactgaa caagataatt 57120 atattactga ttatttatag catttctcaa acgataaagt tgattacaga attcgcgttc 57180 agtcaaaatc gtttcagaaa ttttgttttt gcccatactg tgagtgagcg tagcattccg 57240 ggtagcagcc aaagcttttc tgaatccttc atttttacta agtgcatcat atgctcctgt 57300 cagtaaattc tgatacgctt ctgaagcacg atggattggc acgcctttcc aataaagcgt 57360 ttgagttggc caccaacgtt tcttcttacc tttgaactta gcggactttc cgactagcgt 57420 acatacatgt gcttgcattt caggcgaaga aaatttgagg gactgcaaga atccctccat 57480 tgaggcacat tctacgccat catagataaa tttatgagga gcaaagttgc tcaaagcaca 57540 tgatggatat gaactacctg aaccaatatc catttacttt tccttcacgt atttcaacca 57600 atcaactttt aacgggcttt ctttttgttt atacgtaatt ccaacatgga atgcaaccgg 57660 ggcgtcagga atacggattt cttctttaat atcgaagatt tctactttct caaatactcg 57720 catgaaatca tagtcatatt caatcggatt acctagccaa gcctgaatag catacataac 57780 ttcatttgaa caagaataat gattatctaa ataagcatca aactcttcgt ctgagcaatc 57840 atatgcagga acatcaacac caaagaattt cttggaaaat tcaggagtta catacttctg 57900 ttcagtatga agcttttcaa gaattgcttc atggttgtaa tcattatttc caagacattc 57960 accacgccga ccattagaag agaaccattc aagaacgtga attacttgat taatctcttc 58020 tttttctaag ccataaacca tttgggtaga atatcggtcg gcatcatttt cccaagtggt 58080 aattgccatt gctaagcctt taggaataac ttgtccaaat ttaactttca ttatacattc 58140 ctcatatcta ttcgttctaa ggtatattct ttaagaacaa tctgttgacc acttttcaac 58200 aagaataatt gaataggatt taatccaaac ccgtgttcta aatcatggtc agttaaattt 58260 ctgtcgcaat aattgaaata catgtcaatt ctaacgagaa tggttttcat aactcctcac 58320 acgaatttgg tgaccctggc aaagactcga acatgcaacc aatcccttat gaggggaacg 58380 ctctaccaat tgagctacag ggcctttata gaaatcttat gacttttata aaagccctcc 58440 gaagagggcg ccttgtcggg cttatccacc tgctaggcag aattactcac acataaaatc 58500 agctacttcc cagaagtcat ttttaactgc tactttaacc accggagaaa tttcagatgt 58560 tttaatagaa acaattacat cacctgcgac agtttctacc agaccaacga ttttctcgct 58620 gcgagcaaca aatttactca ccggatgaaa tttaccggta gcagcgaaca tagcttcttg 58680 gtcaacaatc agtgcgatac gtttcattct ttttccttgt ttgtttgttt tgatgtagta 58740 ataataacag gttattcttg tagcattaaa tctcgaaaat cgttccgttt tcccacattg 58800 ttgcgaacat aggagaaacc ttaacgaatg atttgcttcg cattgcaacg tagtcgttat 58860 ctactttagc caatcctgaa gcaatatcag taatacggcc acacttcata gaaccgcgac 58920 cacctttatt gtatgtgcgt tctccgtaga aaacgatatc accaacttgt acttctcgac 58980 ctttagaatc tttcatcata tttcgcctgg caaatttgtt taaaatctaa tacaagttgc 59040 tctacattag tatcagcggt taacggagta acttgccgca gtttattaat tttacaccca 59100 gagtgataag caataatttc ttgaatatca cgttcactaa agtactcata tttgagtaat 59160 gtgtcgtatc gatatttaat ccaaacccac atacctttgc gttcatcaaa tgcatatgca 59220 aagtcagcgt taatcattaa atcccgttta gcacaagatg aaagccctaa tgctaaatta 59280 accggtccat ccaaagacag cttcaccgta atagcattta catcatttga tacaccaata 59340 aaaatattca ttctatttcc ttcgcttgtt tttggccttc ttgtcgtgca cgagaacgtc 59400 ctgctttatg cagtgattcg taatatgctc gacgtctatc aatgttttct gtacgatatg 59460 ctttcccgaa atgggatgtt ttgaagccgt aatatttcat aatataattc tcattggcaa 59520 gtgattggac ggtatgcccg gcctcgaacc gagtcacatt gactttgcag aatccatgtg 59580 tttaatatat cacccatact cgatagcata tctgaacgag actgcaatcc cgctactcag 59640 cttacaccat cttgtattgt gtcataccga taatttggtc tccatagaat gactcgaaca 59700 ttcgacctct ccatcccaaa tggagcgctc taccagactg agctatacgg agtaatttgg 59760 agcatccagg gagaatcgaa ctcccatctt ctgggtggaa gccagacata atatccgcta 59820 tacgatggat gcaaatttgg caggccctga aggaatcgaa ccctcatcac tgggtttgga 59880 gcccagcata atagccgtta tactaagaac ctgttatttg gtgggagtaa ctggactcga 59940 accagtcacc gctcgattat cggtcgagag ctctaccaaa tgagctatac tcccatggaa 60000 agctaatcat ctaattgttg atgtaccact gctatgggca gcgtttaact ttcataaatt 60060 tggcggagag taaaggagtt gaaccctcac cgtttccgat ggcccggatt tcaagtccgg 60120 tttgctacca ctagcgctac tctccaatat ttggtgaagg aagtgccata tagacacaat 60180 tcgcttagcg acaacccagc atgactgtgg gtcgtgtatt tttccaccat tccttcattg 60240 ttggggtgac cgatgggagt tgaacccatg actacgagaa tcacaatctc gagttctacc 60300 aactgaacta cggccacatc aatattcact ccatccatca tgaggacttc atacgaaatt 60360 aagagaagaa tgatcagttc aacccctgta gacgcgttga atgaatatta atttggctgg 60420 actatctgga ttcgaaccag agataccgga gtcaaaggcc ggtgacttaa ccgcttgtct 60480 atagtccaat tatttggagg cggaggcagg actcgaacct gcgcgtgtcg ggatatgagc 60540 ccaacattct accaactgaa gttaccccgc atttatccgg gttcttgaag tactaacaag 60600 tagcttgatg tagaacacgc taaagatata atcttacgaa tatagagctt attccgtggg 60660 aacaaaccgc ttcgtcctcg gcattatctt acaggactca aactcatctt caagaactgc 60720 cacgttctta tttggcggac ctaacggaat tcgaatccgt gactctcgcg tgacaggcga 60780 gtattttaac cgctgaaact ataggtccat aattcgcttt cagagatact ctggcacgat 60840 gccgaagcaa aggggaacag gactctcatc accttggtac cagatgaatc ttgtttagca 60900 ctctgttcta agatgtatcc ctgaaagcga actttcaacg ccgtaagaaa ttataacatg 60960 aacaagcatt aagcaggatg aaatcatact ccttaataca aacgccatgc cagggaattc 61020 tatgccgacg atttatcaga acgtcttctg acttcttcat ttggcgggcc gtgcaggtat 61080 cgaacctgcc tagtcatttc tgacacggat taacagtccg tcgcttaccc tctcagccaa 61140 cgacccgaat ttggtgggac accgaagact cgaacttcgg acacccggat taaaagtccg 61200 gtgctctaac caactgagct agtatcccta aatttggtgg ggagtaatgg agtcgaacca 61260 ctcgagcctt ttgagcaaca gatttacagt ctgtcccgct acccctacgg tctaactccc 61320 caatgggtaa ttttatttat actgccctaa aattaatcag agcagttgat agattaataa 61380 taacaaagaa aacctaaagc atattacaca atcggtgagc tctttgattt aaccaggaat 61440 acccgatgtg gtgaatccat atgagagagc aatacccggt gctcaggaat tggacttgta 61500 tggaaaggaa ccacacgata acctttagga gtaaatccta gcaaaatacc aacgcttgct 61560 gcagaaagtg atccaccaca gtagtatgat actaaatcac cgggctggat ttcattgtca 61620 agagaatcgg ttttggtatg cttaggcgta actaaatcat taggaattgg aacgccttgt 61680 gcatcatagt attcatgggc aagaagctta taattctctt gatagaaagt attaaatgca 61740 gctctgatat tcatcacaat ttcctcacaa ttaatctttg tatgcttcag ttgaaccttt 61800 agcaacggtc tcaaaccgag agttcagtat ctcaaaatag tcttgatacg ttccctggag 61860 ggcctcatag cattcttcta ctgtagagta aatacctctg atttggtcag agccaggagc 61920 aggataataa ttagaccaag ttaaaagtgc atacattact tacgtttcca gctgtagtga 61980 gccaaaataa gaagcactgc aatagcaagt agtgatgaat gcagtgctgc cagtagtgca 62040 cctagtccta cacccaaagt aacataatca tacttagtta cttcttcacg gtttaaatca 62100 tagtttttga tgaaccactg cttaatcttt ttcatgcgct attttatcca ttatgaaaga 62160 aatgataccc attagaaatg caacgcttaa tactgatact gtttcaggaa gagacataaa 62220 ggctgcacct ataatgccaa aacctaatgc tcccatgcag attgttgatg caacatttct 62280 aattaattca caacgtttca ttttattctc ctcaagttga tagggttata gtatcactac 62340 tacaacccgt tgtaaacaac tttattcagc gccagcggct tttaaaagct ttttaagatt 62400 agcagaacct cgggctgaaa aagttacctt accatctttt tcaccgatgc tgccagtcaa 62460 tttagaaagt ttatcactag gaactttttt aaaatcggct aatgtcccgt caacggtttt 62520 tgtaacaatc ggcagttcat catcctgtct tttagcttct gtaataaatt cttggtacgt 62580 tttcatgttg cttccgtctg gttagtttgt ttttgatgga gctatagtat cactactaca 62640 acccgttgta aacaactttg tgaaataaat ttctatttca aatcttctga ccagttcagt 62700 tttagtggct cttggtactc tctatcaagc actacaggta cttgaacttc accctcgaag 62760 tgagctggac cgacattgta gctgagagta atgtgcggtg agtaatctgg gaaatcatga 62820 gttgctccca gagctcttgc atattggtga cggaatttta agtattctga atctagttta 62880 agaactagtg tacgtccgtc ttgcgtgtcc catacttcaa gtttacctga tgtagcaact 62940 tcaaaacttc ctgaagcgca aacgtatgga acatgaactc ttgaatagca tatcgtcgta 63000 tgaatcttat gacgaggtac aggattaggg accttcaact cacgctgaag gtcctcaata 63060 gcatcaagag ttttctcaga gaatttagca gctacatata gaccagtgct aaaatcactg 63120 aagttcatta ggcatcagct tcttcagtag tttcttctgc gaactgtgct tcgatttttg 63180 caaccaggtc atcaagttta acctgaccat cttcactgat ttcaacgccg gacacagcaa 63240 tcagtttctg cagtacttct tcatactgtg cacgcagagc ggacagacct tggatggttt 63300 cagacaggtc aaatacacga actttcagag tatcgacttg ggcttgcagt tgttcagtag 63360 tcatttttga attcctaata tagtgttgat ttttgaataa agttcttcta gagaaccgtc 63420 gttagttatt acgatatcgc cttcgcgaat cggaagtcca cgctctgtga cgtgagtatc 63480 ttttttagaa ccttcttgct caggacgaac tacatgaata actgtagcac ccatcgccct 63540 ggctacatca agttcatggt cttgacgggt atctgggaca atgaaataat cataatcacc 63600 aaaagtatca gccataacca aagtaaatcg ttttacccaa tacatgcgat cgagcttatc 63660 acagacaatg tcagtcccaa gggtctgcat gagacgacga attgaccatg gctcaacagg 63720 tttatttatt acaacttgac ggatgacttc catcgtatcg ccgtcaagaa ttttacgctt 63780 gctatcataa accaccccag gtaaaggcaa atcatgatgg acatattcaa tggcattcgc 63840 cataatacga atcacgtctt tagtagacag atttaaatcc tgctcacgat cgtaatcaat 63900 accttcaatc attgaccgag taatgcgagg aaactgacgt gatgtatcgc gataccactc 63960 agtaagcatt gcatcagcca acgcatcttt aattggacct gctaactgat gctttgttgc 64020 gttatagtta tccataatgt agtcagcagt tgtatctttg ccactacgtt ttttaccaat 64080 caaaaataaa agcttcaaat tattacctca tagaaggatg cattcccata actttctgtt 64140 gatactggga ttcgcgagta tcattgacag aaggtctacc agtaattatt ataccatctt 64200 tttcaacttc aatgtatttg tactgcaaag ttgctacaca taccattgct gggtcggatt 64260 cttcggttaa agaatactca atttcagata aatcactcac ccaacctccg atatagcgga 64320 cagttaatac tatatcacgt ttatcgttat caagaacatg cattaaaact gcgccaggaa 64380 atccttcacc gccgttattc catccagact tgtctcggtc aatgtagttt tgacagctta 64440 acatccattt gtacatttgt acccatgaat caagattttc atctactaaa aatctaacag 64500 gaacagcgtc aaactcaaaa gtagacccag gcaatttagc acgatgcatg ccttgaggcg 64560 aacctacagt atcagtagca ggaatatgaa ttccaggaac tacggctgtt tgaagattag 64620 ctttaaacgc ttgggtgagg cccccatcag ggacctctaa tataaagtta gttgtgttag 64680 tttgattaaa cagtccagta gacattatga tttccataca gaagtagcag agtagcgttt 64740 gcctttcgac atgaactgct gcagtggtaa catgactaca ttcgcccaat cagccggttt 64800 tatctcaatt aaagcaccct ttatattacc aggaatatat gctttaatca ttttgtcagc 64860 gccagcaaat cctttaactt ggctccagtt tatctttaat ctggtcttat tagatatcac 64920 tggcgtatta gcatgctgtt taagaagttc ttctaaaaac tgctgacgag cctttggcgg 64980 aatgtagtga aggtttaacc catacatcaa tgtggttgta ccttgctttc caagaccaag 65040 ataaactatc aaaggaaatt tatcccagaa tggaagagtg tctttgtgct tagcgtcata 65100 catgtaagca tatagctttc caggttgagg cttggttaca gaatgaccac gtatattttt 65160 ctttatagtt tctgcaaacc atttagcaga tttattgttt actgctgcgc cttcattacg 65220 aattttatct ttgatagagc ttcgaaatga atttaccatc acaagagcac gctcttgttt 65280 ggtcattttg ttagcaggtt ttttctcaat ttctgctact ttaattgccg ttttaattct 65340 tgatgcatga cgagccattg ctttactgaa tgtagcagga tttattcctt tgctttcagc 65400 gaatgattta gacgtcatgc cttttttacg agcagcagag tattcaactc ctaatgctac 65460 ccattgattt tcactacggg atttagcttt aggcgattct gcagcttcag tgataaattc 65520 aaatatagcc atcagccttt ccatcctaat tttttaagtg aatcttcggt aattaaccta 65580 aattctatac ccattttact ggcagtagct tgagctgctt tccacttatc aacgtttaca 65640 gaccaagtgt aaatttcatc aatgtaccgt ttcttcgctg atgtcgtcaa ctttgtgggt 65700 ttgaccggag gtctagtttc tttctttggc ttaacttcaa aaaagaactg ttgaccatta 65760 gaaaacttag cccagaaatc catgaaatac cggcgtttct ttccatctgc attactaaag 65820 tatggaatga ctacttcttc gctattccat tggactacat ctggatgatt gtcaagccaa 65880 cgcatcatgt actgttccca tgtagaacga taagtaatct ttctaaagtc gcctttatat 65940 ttgtggagat tctgtggcat gaatttgcca gaatatgcca tagtggcctc cttataaata 66000 ctgttattaa tatttataag aggataaact atgctcttct cattttttag tccgatagat 66060 tattctgcaa agaccgtaaa aggtgctaag gcaaaagcta tcccaaccgc tgacatattt 66120 cgtaattatc gcaaatattt cgacactgta gcagaaaact atcttttaca aacatattac 66180 ataagtggag ctcctagacc agaagaatta gcatatattc tttatggaaa tagtcagctg 66240 tactggattc ttttaatgtg taataatgta tatgacccgt ttagagattg gattaaaacc 66300 caggatgcat gctatcaatt tgcacaacaa aaatatgcag atgtaggtgg agaccaaata 66360 ctctatcacg tggatgcaaa cggcaatcgt tattataacc tcgagcaata tcctgaaaat 66420 tcaggcattt ggtatgataa aggggacttt aatcatcagt atcctcaata tactggtgct 66480 ttggctggtg ttgacattta cgaagattct attatagaaa atgaaaaact gcgccaaata 66540 aacattatca atcctagtga tattgaagca tttctttctg atattatacg agaaatggaa 66600 aaggctcctg acagtgaata tgaatcaggt cgatataaat cccagactac catcggagaa 66660 gttttatgat tgaaatgaac gattcattaa aatggtttac cggtgttgtt gaagacagac 66720 aagacccgtt gaaacaagga agagtgcgag tacgtgttta tgggcttcat ccatttgaaa 66780 aggtgcaagg agctataacc ggtcttccta ctgaagacct tccctggatg tcagtgattc 66840 agcctaccaa ctcagctggg atttctggag ttggctcatc tataaccgga atggtagaag 66900 gaacatcggt gtttgggtta tggcttgatg aattcaaaac agcaggacta gtaataggaa 66960 catattctgc gcatagaaaa acgaagccaa actatacaga aggattttct gaccctacag 67020 gtcaatatcc tagacaggtc gggtcagata ccaacccact agttcaaggc gatgaaactg 67080 ggtatagtgc tataccaaat atcattcagg acagaaattt agacattggc attaatcctg 67140 atgatgctga cttaagtgat attcctgaag acccaaatcc tgcaattaca ataacagata 67200 tgcttaatag ggatgaaggt cttagattga aggtctactg ggacacagaa ggatatccta 67260 ctataggtat tgggcatctt atcatggcgc aaaaagtacg tgatatgtct gtcatcaata 67320 aaacattatc aaatcaggtt ggtcgtactg ttacgggaaa tcccggtatc attacaatgg 67380 acgaagcagt cgcgttattt aagcaagacc gtgataaaat gctttctgac attaaaataa 67440 attcacgggt aggacctgta tatgctaaag tcaacaagtc aaggcagatg gctttagaaa 67500 atatgagttt tcaaatgggt gtaggcggtt tagcaaaatt tggtaaaatg cttgatgcca 67560 tgttcattgg tgattggaaa accgcttata cagaagcaag aaactctgtt tggtttaatc 67620 agacaaaagg tcgtgcttct cgtgtttcca tgattattct aacgggtaat atggaatcat 67680 atggagttcc tgctccaaag ccagaaggaa aaaacctgtc tgctgcttac gtagaaccaa 67740 agtctggagg taatcctgaa gacccatgga ctccggaaga ttcaagaatt cttttcaaag 67800 aacctgagtc ttcatataat ggtcagtatc catatgttca cacaatggaa acagaatcag 67860 gccatatcca agagtttgat gatacacctg gctatgaacg ctatcgtatt gttcacccaa 67920 caggttcata cgaagaagta gctcccgatg gacgccgtac cagaaaaact gtagctgatt 67980 tatatgacat gactcagggc gatggaaata ttttaatctc tggggataag aaggttaacg 68040 ttggagggaa cgagacctat tataacatgt ataatcgtcg acagcaaatt gatggcgata 68100 acacgcttta tgtgcgtgga aatgaaacta aaactattga aggcgatggt actatttttg 68160 tcaagggtaa cattaagata gtcgttgaag gaaatgctga tatccaagtc aacggtgatg 68220 ccactactaa agtagatggc aaccacgacg taaccgtcgg tggtaactta acttggcaag 68280 tagcaggtac tgtgaattgg aatgttggtg gggcttggac tgagacaatg gcttctatga 68340 gctcaatcgc ccaaggtcaa tacactgttg atggttcacg aattgatgta ggttaatcat 68400 ggctgatata cttcctatta ataccacgtt acgcgaagta atagaaggtg aatacgttga 68460 gcagtacttt actgctcaat tatctaccaa cgaaacatta aaatcaataa atattatcga 68520 ctatcaacca gtatctgata tctctgtgtc tgaaacctat tataaaggta attataactc 68580 agtttttact tttggaaacg atgtgcttaa ataccgtgaa ggcgatgagc tgaagtccgc 68640 ttcagcgtgg gaggatttac ctaatcccaa aactgctgat ttatatctgt ggaaagcccc 68700 cagaacacta gagaagacat ttacctatac agttgagata atatatacag tgacagaaga 68760 atcgtctgga ggttcatccg gaggttctag cgctccaatc gtaacagaat ataaaaagca 68820 aaaggtttac tctcaaaccg ttaaaggtaa ctggagcaga tggggcgacc aacttcgtgc 68880 ttacgtatat gcggggaatt aaatggctgg tctttcatat gataaatgcg taactgccgg 68940 gcatagtgcg tatcctccga cagaagtaaa tgctacacaa agtaaagtat tcactggtgg 69000 aatagcggta ttagttgatg gtgactcaat tacaccgcac accaagacgg ttgaccctca 69060 tgatacgcat ggaggagttg ttcaacctcg cacatccaag gtatttgtaa caggcaaaaa 69120 agctgttcaa atggccgatc caatttcttg cggcgacact gtcgcgcaat caagctcaaa 69180 ggtattcata cactaatggc tattaaagaa cctttaaatt atcagttaac gcgtactgca 69240 aacgctatcc cagacgcatt tactggagca acattcgacg aaattaaaaa tcagcttatt 69300 aactggctta gtggtcaaaa agagttccaa gattttgatt ttgcgggttc gcgcttaaat 69360 gtgctattag atttattagc atataacact ctctatatac agcaattcgg caatactgct 69420 ttatacgaaa gctttattgg aacagctaac ttgagaagtt ctgttgttca agcagctcaa 69480 cagaacgggt atttgccaag ttccaaatca gcggctactg cgtctattat gcttgaggta 69540 actcatccaa atccagagcc agcaataaaa atacctcgtg gaactaagtt tttggcatat 69600 gcgcgggatt catcagtaga cccatacaac ttcgttgtta ccgaaaatgt tattgcttta 69660 agagatactt cagcaccaga aggagttaat aggtatcttc ctattgtcaa tttggcacaa 69720 ggacgtatta ttcgtactca attgtcatat gacccgaaga aacctattgt tattcgtgat 69780 cagtcgattg accgtaagca agttaagctg tgggttgatg gcgctgaatg gactaactgg 69840 acagacaggt caatggttca tgcttcatcc atttcaacaa tttattatat gcgtgaaact 69900 gttgacggaa ataccgaatt cttctttggt gaaggcgtgg cagaagcctc tgtagcagga 69960 ggagttcttg aaagtaattt cattggtgga ttaaaaccta ctaagggcgc gcaggtagtt 70020 attgaatata ttcgtactga tggtgaatct gcgaatggcg caactgattt cagctatgct 70080 gatactctgc aatatattgt agtaaacaaa atcatcgaaa actggtcgga ttctcctgac 70140 tacgttggag ctgatggtgg tggggaacct gaagacattg aacgtattcg cgaattagca 70200 caaattaagc gtgaatctca aatgcgttgc gtgtctaaaa ctgactatga gtcattcgtt 70260 agctcgcgat ttggttctat tgtgcaggca gtacagtgct ttaccgacca agataagcca 70320 gggtatgcgt ttattgcaat taagccaaaa tctggactgc agttaaccgc tgttcaaaga 70380 gaagacatcc aagattatct tcgtccattc tgtcttgctc ccattacccc ttcggtaatg 70440 agtccagact acttgttcat ccgtcacaat attaaagcct cttacgcgct gaataagtta 70500 caagaatctg agcagtggtt acagtcaaaa attatagact caattaatag atattacgtt 70560 gatgaagttg aaatgtttaa caaaaatttc agtaaatcta aattattgac ctatattgat 70620 gatactgacc attcaatcat cggttcttct gttgatattc agatggttcg tgaaattgtc 70680 aactatttca ctcttcctag cgcaggtatt aaatactata atactattac tccgcggacg 70740 ttacgttctg gcgatttggt ctttactgtc actccaactg cagattcata tccagttaat 70800 atcgttggaa ctgacccaga taaaaatggt aaaggaaata tggtcattgg accatttaaa 70860 ccaggtgata ttaaagagaa tactcatatt cagccatata ctgaagacga ttttgataga 70920 actactaatg gagaaagaac tcgttggtac aaaatcggtg aagtagatta ttatggtgat 70980 aatatttact ggagccttgg agctattgga gccgatcctc ttcagtttga agaccaaagt 71040 attgagcttt attctactcc tacccaggat atcgtcttcg cccgcgatgg aacacttatc 71100 gtatttgaga atgaccttcg tcctcaatac acaactatta aattggagcc tattactcaa 71160 tgacaattgc accgttcgtc accagcttac gaattcataa gctatctgcg aatcaggtca 71220 atattcgttg ggatgacgtt ggtgcaaact tctactattt tgtagaactg gccgaaactc 71280 gaaacagagc gggggaagtt atccccgctg ataatttgag ttggtcttca ctgggttata 71340 ccgcggataa tgattggttc gaacaaaatc gtattgaacc gcttacttat tataaaatgc 71400 gtgttcaaac tacgtcagca gggtttgagc cgtctgaatg ggttgaaaca gaagagttcc 71460 aaactttcga agaaaacgca tacacatttg agcatatgca agaattcagt ttagtgaaag 71520 aattcattaa acagaagttt tctttaaaca acatgtcgta tgttaacttc aacacatctg 71580 ccatgatggc gtctttgatg actgagtctt ttcagtttag tcctgaatat tctcatttat 71640 cagctattga aaacttcgtt gtaggtgaat ctggatatca tgaaattcag ggacctattg 71700 aagcagtgtg tgttgataaa aatagaacta tgctgggaga aatagacgga attttgtatc 71760 tgtttgaaag attccaacat atggttaaag tatcaaatga taaaggacag aattggcaat 71820 acgttcagtt atttaatgac cgcgtcggaa atccggtttc tagagtggta atttatcaat 71880 ctaaaactac ttcttatgtt ttaggatatg ataaaatctt ttacggaagg aaatcatctg 71940 acgtgcgctg gtcatcaaac gaggttaagt ttagcgataa cgaagttaca tttgctaaat 72000 tgggagacca gttaaagctt ggctttgaag tagaattatt cggaacgtat gcatcattgc 72060 ccgctgacgt taccaaatat gctgaagcgt ttacatgtaa tgatgactat ttgtacgttg 72120 ttgcaaaaga cactgtccgt aaagttaaat taaaagatgc tccaatagat actgaccctt 72180 taagtcctac atttggtgaa aaggtgtttg aaaaggaagt atctcatata acaggcaatc 72240 ctaaatctgt atgctttaaa atggattcag ttggaggcaa aatctttgcc cttattaccg 72300 gggaagttaa aaccttagga ttagacccaa cagacccaag gaacgttgtg gattctgcaa 72360 ctaaaggcgt ctatgtttac caggaaggca caaatacttg gaagcgtgta tttggtaata 72420 ccgatgaaga aaaacgtcgt atagagcatt tatggacttc tatgtcaact gacggaaagg 72480 aaatattctt ttcatcagct aattttaaga caacagagta cgctcaggat attgagcttg 72540 agacgaaata tccagaacta atttctaccg cagttaaaaa tgttaatcca attcagtatc 72600 actctgataa gcattatcac atgatgagtt tcagagcaga tgaattttca agatgggaaa 72660 catttgttcc tggacctatg aggttttatg ctgaaccatg gtttgtatgg atggctcgcg 72720 aaggtaacag atgctggata agcacatcag acaatgctgt agtcgtgtat aatgatattc 72780 tttatcagaa aagagtagat gcagcagcac agggaactac cgagcgcatt ctttcggaag 72840 tgtgggataa aggtgacgca acgttttatt gccctccagt ttcatttaat ggatttttgc 72900 agtatgcttc tggcatcatg tttcacgaac cagacggaaa actgataggc tattacgcat 72960 ttgactaccg tgttcgtgac caggtaacgc ttaactggaa accaactgat gtaatgttta 73020 aggcgtttct gcagaaccaa acacgggaag aagactggac acctgaacat actccaggct 73080 tacgtgaccc agatttgcgt ccgtatctta ctaaaatgat gccggatagt tacttgctac 73140 aagatagtaa ttttgagcac ttttgtaagt actatctcca attcctttca gatggaaatg 73200 gaacacatta caacagtctc gttaatcttg ttaagaacaa gtatcctcgc gaagaaaatg 73260 catgggaata tctgtggtca gaagtttata aacgcaacat ttatctgagt aaagacgctc 73320 gtgacgctgt cgtccgtttc tttgaagcac gcaagaatga tttctatgct actaaaggaa 73380 ttgaagactc atataagttc ctgtttaaac ttctttataa cgaagacgtc gaaatcgata 73440 ttgagtcaaa gaacactacc gaatatgaca ttattgttga aagtacaaat atttctgacg 73500 atttagttgg tcgtacgatt tatactgctt ccggtcgtag taatgtgact tatatcgaga 73560 gagaataccg ggatggtcgt ctgttatggc gtattactat tcataactta tcaggacggt 73620 tcattgaagg ccaggaaatt aaatcagagc gtacggactt tgagggtatt atagttcaag 73680 gtgttcgtgg aaaggatatg ctgagtaata acattgatta tataaaccgc agccgttctt 73740 actatgttat gaaaattaag tctcagcttc ctacttctcg tttccgcgac gatgtattaa 73800 ggtttgttca tccggtaggt ttcggtttca ttggtataac attgctgaca atgtttatca 73860 atagtggctt aaatatgaag catgttgaga ctatcataaa taaactcaag aactataaat 73920 gggatgcagg actgccatca gtttatcctg atagagttgc tattatcgct tcagatgata 73980 caatagaaag agacccaata accaatgagc ctaggtattc ttcacgtgct caagctggtg 74040 aacctttccc gttacctgct aactataatc aagaaaataa caatagtgtt atcgctggac 74100 aaaaccctgg acaacgacgt aaaccgttaa gtcctacatt tgaccaatca gcagtaacgt 74160 ttgctaatta tcgcgattta gttaaccaac gtcttaaaga cgatgcaggt aatcctcgcg 74220 atcctgaaaa tccgacacag gtaaaaattg atgagtaatt caacaagagc aagttcaacg 74280 cgtagcacga tttatcgtgc tatcattaca tctaagttta gaactgaaaa gatgtacaca 74340 ttttataaat caattggtcc gggaacggac caaaacacat tgtatgtttc atttggaaaa 74400 agcactccat ggtcagataa cgaatctgaa cccggatttg cacctccata ccccgctgat 74460 aatggagatg gggtagttga tgtttggaca aatatgatgg gtgcagtcaa aattgaatca 74520 tctatgcttg actgtgttgt tccaagaaga gactggggag atacaagata tcctaacccg 74580 cgcacatttc taattggcga tatcgttgtt gctaactctg cgccatataa cagaactgat 74640 gctggatttg gatggatggt atatagatgt attgatgttc caaaggatgg aatgtgttca 74700 attggcaatc ttacaagcaa agaagaatgt attaagcttg ggggtaaatg gacaccatcc 74760 actatttccg gctcagctcc tcgaggtcgt ggtgatgcaa atggtactgt cgatttgggc 74820 gatgggtatc tttgggaata tctatacgaa attccagccg acgtatcaat taacagatgt 74880 acaaatgaat atatcgtagt tccttggcca gaagagattg aagaatctcc agcccgttgg 74940 ggatttcaaa acaacttaac ttggcaacaa aacgacttta acctaatcta tcgtatgaag 75000 tgtaatacga ttagatttaa agcatacctt gatgcaattt attttccgga gtttagtctt 75060 ccgggaaata ctgggtttag gcagttgtca attataacta atccgcttga agttaagcca 75120 atgccaaatt ctcctaacgt taaggctgaa aaaggttggt atagcgcttc tggtcttgaa 75180 agacagtcag gtgaaatgat ttacatggaa aatcgacaac ctattatacg ttcaatggac 75240 caaacagaag agttaaattt aattttcgag ttttaattat ggggagcctt tggctcccca 75300 tttttatata aataagacta tactttgata tgaggttaac ctatgtatac agataagggt 75360 aaaaaaataa ttgacgtcgg tgagattggt aatgcttcta ccggcgacat tctgtatgat 75420 ggcggtgtga aaattaatga taacttcgac gccatttata acgccttcgc tgatcaacga 75480 ttatttgcag ccggtggtgg agctttaaac caaaaaatcc acgcaacaag ttattatcaa 75540 aagataaaat ttggtgatgc taactcggcc ggtacagttc cgatgggttc atgtatagat 75600 gctgattgct cagaaggggc agttcaaatt cgtctttcaa aaggtaaagc gggagaagct 75660 gtattcgttg taaatagtaa tggctcagca tcaaaagcta gatccataaa aataacaaca 75720 aacggcgaag gtgtagcaga tgcatttaaa gacggatcgc gagagttgat tatcaacacg 75780 ccaagatgta gaattgaatt gtggtgtgtt gaagtcaaag ctaacggtgc tgcagtttgg 75840 gattattcaa tttcaagtat gtttggcagc acatattcgc cgttagaagc tacatataat 75900 ttaacgagtt ctcctattaa tattcggctt ggatataacg atgattactc tactgttaaa 75960 ttgttattaa gcttcagcgc aaatccaggt ggtcaaacca tcaaaaggca atcatctgaa 76020 gtcatgctta tgattgaccc gactattact tcatcagcgc caaacggaag agtatttgac 76080 actgaatatg cagtgttaag aagcggtgaa tcatctgaaa atgaaaagat gtattctatt 76140 tcatactcta ttaacgcgca gaaagattta atatgtacag cttcaacatc atatggaaac 76200 gcacgtttgg cagttaaagt tattgctaca cagaccgtag gggtatctca ataatgaaac 76260 aaaatttgat agtaggccaa tcagtagatg atgggtctgg tgattacctc cgtaaaggtg 76320 gtcttaaaat taataacaac tttgatgatt tatattcaga gttaggtgat ggttcagttc 76380 cattcgcagc aggtgcatgg aaaactttta aagctagccc tactggaact actttaaatg 76440 ctaagtttgg tcaggccttt gctattaata cacaggcagc aagagttaac gttcagcttc 76500 caaagggtac agccaacgac tataacaaag ttattaaact tcgtgatgtt tggtcaacct 76560 ggcgattaag cccaatcaca gttattcctg ctcaaggcga tacattaaag ggttcagctt 76620 ctcctaaaat tttcaatact aacttccaag atttggaatt ggtttattgc gcccctggcc 76680 gctgggaata tattgaaaat aaaacggtag ataagctaac taacggtaac ttaagcactg 76740 tagcgaaaaa atcaattatt gctactgcag gtcagactga ctttcttaac atttttgatg 76800 gcgtagaata taacgaagac tcacttaacg tatatcgtcg tggtaatatt ttatactacg 76860 gtgaaaccag cgttatggat aaagctaatg ctgactacgg ttctcctgga acagtagcag 76920 gtcaattggt agaattaaac ggtaaagaca ttcgtttaaa agttccatgt gttgaagggg 76980 aagtaataac atttgaaacc ttcctagatg gaattggtgt ttatcggtct tcatacaaca 77040 agttggctat ccagatacga gattcagccc agactacatc ccagacgatt cctgggtcaa 77100 tgatagtaga taaccttgct actctccgca gaatcactct ggatgacatg ggtgtacttc 77160 caggcgtagg ggtaaatcct aactcgcttg aaatttcatt gaacggaaag gaattactcg 77220 aagctggaac tgcaggtctt cctttatttt attgtgaagg tgcggaaggt ggatacgcag 77280 aagactgtat aaacaatggt ggtcaatggg taaattctaa ccaagactat agactggaat 77340 ttgactcaac tggtactaac gtcgaagcta ttatttttgg tgaggcgttt gaagataaag 77400 accttcttac cgtccgttgg ttcaataata acatcggtac tactatggat attgacgata 77460 tcatggcaga aaccgaccaa gtgtatatga atgctgagca attagtaact ctaaaaaatc 77520 gcattgaata cacaaattat gatgaaccta atcagaaaaa tatgcgtccg gttgctgacg 77580 atattatgat taaagtcaat aatattgcag cgttttttga cgtaatttat ccgattggca 77640 cgatttatga aaacgctcac aaccacgcaa accctgctga ctatatggga tttggggtgt 77700 ggaagcttta ttcacaaggc cgtgttactg ctggttggaa taatgattca tctgatcctt 77760 atttttcgcg taacaacaat aacttaaacg aaaatggtca gccatcatta acagcaggtg 77820 gaacggttgg agatttgaca tttacgttag gaaaagaaca cattcctgaa ctaatgtcaa 77880 gagataaagt tctaatttca gaccctgaac acggaagcgt agttatcggt ggatgtcaat 77940 tagacccaga cgcgcaggga ccaggttatt ctaaataccg tgaagacact gttgcggtaa 78000 acaacggtgt agttccaaat gacatcacta aaattcagcc aacaatcacc gtttatcgtt 78060 ggattagggt aggttaaaat gacgattgaa actaaaactc gtgaaggagc taaagttaat 78120 tcaagattag ctgctttttc agaatatcgc gttgacccgc aaaatattgc ggtaggaaat 78180 acggctccta tagggagcct aacctttgaa caaatggatt taggggtttg gtatccaaat 78240 actgaagctg ctattaatga tttgatgtca ttgcagtcag cagaaattgg aactattatt 78300 tgcaatgaca ctggaatatc tccacagccc gcacagcaaa ttacgcgtgc tactttttca 78360 ggtgtcgttg cgttagagcc aaaagaagac ggctctgtcg gtgacccagt aataattcat 78420 attcttggct taccaattag aattgcaaac ggtgatgact ttgcagcagt agcaacacgt 78480 tggtatgata aagtaaaaga attagaagct gttggaaagg ttgttcaaca ggttactcaa 78540 tcgccggcaa caccccagta tgttgatatt attcatttag attatcagaa ccataatttt 78600 gaaacatata aaaagtatgg tttaactgtt gaatttacta ttacttcacc agctaaagca 78660 ggttatgggc aatgggatgc tatcggcaac gaatctaaaa ccttcggcgc gaacacattt 78720 actttccact attttagaag gatgggataa tggcccagaa taactataat cactacagtg 78780 atttggccaa atatacgata tttgacccaa caaatacaca atggcctgtt gctataaaag 78840 acgtccaatc agcgttagag ctgattggta gctgggcaag aactgatacc ggattacctg 78900 tagcatctcc tacagtagcc ggtgtaattc gcacagcaac acaggctgaa gttgatgctg 78960 gaactattgg taatgctgcg gtaactcctg ctacattaaa atccacagtt acccgtcctg 79020 aagcaactac aacagttctt ggcttaacac ggtatgctac taatactgaa gccgcagcat 79080 taaccgcagg aaatagaact attaccgcgg cggctctcgg tcatgtgttt aaaactgtga 79140 aagcccaaga aaacgtagat ggaactgtta ggttaactac tgcggctcaa gcacaagcag 79200 gaactgacga aactaccgca gtaactccta agcgtgttgt agaaatgatt ggaaagttca 79260 gtgtcagtcc tcctagttat acctctgcga cagaaagcaa cttgggatta gttcgtgtcg 79320 caacccaagc ccaggtagca gcaggtgctg ttcacgatgg atacgcagta actccaaaaa 79380 ccttcatggc atcaaaagcg tctgacagtg tatttggtat agtaaaattt gctaaagact 79440 cagatgtggc ttcagctact tctaacaatt tggctgttac tccaaaaagt cttcaagcgc 79500 taaaatccac caaggataaa tatggattaa ccagattatc aggttctcca actactgatg 79560 cttcattggc agcggctgca acagatgcag tctttaaaac ccgtagaata aacggaaaaa 79620 ctcttgataa tgacataaca attactaata atgatattaa ttgttataca agacaagaat 79680 ctgacgggcg ttacatgcca gctggaacca gagtaggtaa tgttacttgg gttgaaggac 79740 aatcttggat tagtcgaggt gcaacgttta catgtaatgc accatgggaa gcttctagta 79800 aattagctct aaatgttaat gtaaaatttg agcgtaacaa cgacggatat gacaatcgta 79860 ttttcaaatt tgttctaata gttaacggct cccaatgggg tggtgaactt actcttaaca 79920 tcgaaaatac taaaggcgga cgaaatggtc attcatggag atttgaagct tacgcatcta 79980 gcaacttttt cttcaataac attcctccaa atgccactgt tcaaataaga ccaacagaag 80040 acagtcgtat tatattttat gactgcatgc ttacattctg tacaaataga ccgtaaggaa 80100 taatatgacc aaactagtag attcgcttcc gtttgtagac ggaattccgg acgattttca 80160 acagagaatt aactggataa aaaatacaga gcctcttaat ggggcttcaa cccgctatgg 80220 aaatgatgga gaactgaata gagcttctgt gcagattcag aaaaatgtgg ttcaggtaca 80280 taacgatttg aacaacgttg gaactgctgt agaaaatatt caagtagatg tagaccaaat 80340 caaaaaatcg ttagaaatta caggttcttc tgacgccatt gagcaggttt atatcaataa 80400 aaagaatatt gaaaagcatg atggacaaat tcttaaatta gaagaagaca ccgaaaaact 80460 tcgaactgac cttgattttc tcgaagagga tgtaggtgtt tatgattcta gtaaagatga 80520 ctattacaga acagttcgtg ataatatagt ttgggttaaa cgtgaaattg gtgcgtatcc 80580 tggacaagat attaacggac agccgaagca agactctccg ggttctggta tgaaataccg 80640 aatcatcaat aatgcgtcag ctatagtaaa acatgacgag cgtattcagg cgctagagga 80700 tgcatacaat gattcagacg taggttctct gactattgaa gtaaacgacc tgcgtaaaga 80760 agttggtcct aaatccggag ctacgtcagc ttcaatttat gcaaggcttg tgaataacgc 80820 tgatgctatt tccgcagcta ataatgaaat ctttgctatt aaccaagcca ttgattttac 80880 caatccagta aaaattggag ctcgtactac tagattagaa aacgattatc gtatagttga 80940 cgcaacactt aactctgcac aaaccgggtt agttcctcgt gtcaataata ttgatgctcg 81000 tttggggtct tctgataagc ctgatactat tgaaggaaaa attagttctc tttcaactga 81060 ccaggggtac atttctgatg ttgtaggacg tgatacttca tcaggactcc agggtcaagt 81120 agcatggata aatcagcaag ttggtattgt tcctggcgga cagccgattc ctcctgggtc 81180 aattttagcg agaatgacca atgttgaagg gatgcaaaac tctcagcagt ctgctatcca 81240 ggacattcaa gtagaacttg gcaataacag cgaagggtta aaaggttctg tatttacgtt 81300 acagactcaa atgaatggtg acttttcgtc agaaaatccg gttcagcggg atggtgtgta 81360 tgccactgta gtagaattgc aagataaatt cgtgactgca gttactgacg tagaacaaga 81420 tggagcatac ctccgtaaac ggggcgaatg gtttaagaag ccttcatcaa taggtgaatt 81480 cagtaaagaa gatttcactg ttgatttaag ttctgatgca ttggtaaatc ctaactcatt 81540 ggtcgctgct tcatttaatg ctggcattcg tattgttgat gatattattg ttgatgacga 81600 tggcgtattt tgcgtagaaa ctgatacagt tatcgaagct tctgattcag ataaagcggt 81660 taagattgta gttctcgtta ataacattga ggtgtttact tatagcctag gtgttaaagc 81720 agtaaccggc gagcaactgt tgaaaaccaa gaaacttatt aagttttcgt ctggtgatgc 81780 aatcaaaatt gtgtatagag ctgcttcaga agaatcaaaa gttcctgtta gtattaaatc 81840 attggatatt actattcatc cagcagtata atgaaaggga ccttcgggtc cctttttcgt 81900 ataaatagaa tataaagagg agcttatatg tcatacaaca catacaaccc aaaaacgctt 81960 aaagacgcta tacttcgacg tctaggagcg ccggtaatta atgtcgaagt aactgaagac 82020 caaatttatg attgtattca acgagcatta gagttgtatg gtgaatacca ctttaacgga 82080 ttgaataaag gctatcaagt tttttatatt ggaaaagatg aagctgacaa cgcaagattt 82140 ttaaatggtg tgtttgattt gcgtggtcgt aatgtatttg ctgtcactca aatcgttaga 82200 acaaatgtag gttcattaac ttcaatggat ggtaatgcta cctatccgtg gtttactgac 82260 tttttaatgg gaatggccgg aattaatggc ggaatggggt caagctgtaa taagagttat 82320 ggaccaaacg ctttcggtgc tgacctgggc tattttactc aattaatgac ttattggtca 82380 atgatgcagg atttgcttgc cccacttcca gactattggt ataactctga taatgaaatg 82440 cttaaagtaa tgggcaactt catgaaggga gacatcattg tttgtgaatg ctggactaaa 82500 tcatttatga ataccgacat gatggtaggt aatactgcag gttacggctt cgctggtgaa 82560 caaacttccg accattgggg cttaggagat aggtatcaga atcctaacct tcgtaataac 82620 ggccaatatg caggtgaagg taatacaaat agagaaggtg cttataataa tcgttgggta 82680 aaagattatg ctacagcact gactaaaaaa ttgtggggtg aaattctgtt taaacaccaa 82740 gggctacaat tagccggcgg cgttacagtt gatggccaaa cacttaaagt agaggcccaa 82800 gaagaaatcg agaggctccg agaggaactt gatttacttg acccgggttg tcctattctg 82860 ttggggtaaa agatgactac atttaattct agtttattcg ctcgccttga ggattaccga 82920 ggatacaata aaactaatga gacagaaatt ctcaatcctt atgtgaattt ttataatcac 82980 agaaatagcc aaacgttagc agatgtttta tcagctgagg ctattcaaat gagaggaatt 83040 gagttttatt tccttcctcg cgaatataac aatccggatt tgcttttcgg agaagaccca 83100 tcaagtaaat tcaccaaggc ttggaaattt gctgcttact tagactcttt tgacggttat 83160 tctggtgata acacgttctt cagtaaattt ggtatgatgg ttaatgatga agtcaatttg 83220 actattaatc ctaatttgtt caagcatcag accaataatt cagaaccaaa ggcaggtgac 83280 ctgatttatt tcccgatgga taattcgctg tttgaaatta attgggttca accatatgat 83340 ccattttatc agttaggtca aaatgttcaa cgtaagatta ctgcgcagaa atacatttat 83400 tccggtgagc agcttcaacc agaattgcag cgcaatgaag gaattatcat tcctgagttc 83460 tctgaacttg atttagaacc aatcaaaaac attgattctc ttgctgatat ttctgacgta 83520 caatacgcag aaagcgatgc aattaataaa gaagcctctg aatatgttca tccgtattat 83580 gttaataacg gaagaggact tgagtctcct cctaaagcag attcgtttga tgacggattt 83640 tttgaataaa taaaataaag atgggacctt tgggtccctt aggagaaatc atgtttggac 83700 attggtataa ttcgtccttg cgccgataca ttgtattgct gggagattta ttttctcata 83760 tacaaattgc tcgctggcgt gaagacactg gactaaaata tattaaagta cctataactt 83820 atgcttcaaa ggaaaagttc ctttctcaac tcggaaaatg gactgctatc cagtctaccg 83880 agaataaagc aaaaatagaa actgttttgc caagaatgaa tttacacttg gttgatatgc 83940 aatacaacgc gatgtataaa acatcacagt tgaatagaac caaatcatat aaaacccctt 84000 caaaaattac atctcagtat aatcctactc cgattaagat gatttttgag ttggggattt 84060 atacacggaa ccaagatgat atgtatcaaa tcatcgagca aatcgttcct tattttcagc 84120 cgcattttaa cacgactata actgaacttt acgacaaaga cacgagcttt aaccgtgatg 84180 ttagaattgt attacaatca ttttctccgg atgaagctgt tgacggagat aatattactc 84240 gtcgtagatt agaatggtca ttgatgtttg aagtcaacgg atggctatat cctcctgttg 84300 ccgaggttga cggcgaaatt agaaccattt atttggattt cttcgctaat agtaaagaat 84360 taacgccaga aggaaatttt gaatctgtgg atagcgaagt tactccacgt gatgtccagc 84420 aagaaaactg ggatggttct agcaaacaga cgtattctca cgatattcct attccggtaa 84480 atccggaggc tcctggaccg agaggtgaaa aatgagtgac ttacaattag atatggctaa 84540 attactagac atcgaaggaa ttcccggaat agaagggcaa gaaattccgg tttatgaaaa 84600 attagaatta gtcgaagtta aatctaatcc aaatgatcgt aaacctgacc ttgaagacga 84660 ctattctgtc gttcgtaaga atatgcactt ccaacaacag atgttaatgg acgcagctaa 84720 aatatttttg gaaactgcaa agaacgctga ttctcctaga catatggaag tatttgcaac 84780 tcttatgggt cagatgacca caactaacaa agaaattctt aagcttcata aagaaatgaa 84840 agacattact tctgagcagg ttagtactgg aaaaggagct aatcctcaac aaggaatgaa 84900 tattcaaaac gcaacagtct ttgtaggttc tactgccgat atgatggatg agtttggaga 84960 cgcctatgaa gcacaagaag ctcgagagaa aatagtaaat ggaacagact caaccgttta 85020 atgttctgag tgatgcacat cctttaaatg acggtaaaca agtggttatt cgccacccgt 85080 ctgaaatgga aacgaaaatt gaaaatggag ttcgtttctt taaatcgcaa tgggatgata 85140 agtggtatcc tgagaaattt gaagactatc ttaagctgca cgggatagtt aaaattcgcc 85200 tgcaaggtga agacccagcg cattttcaaa cgtttaagga taaaaataat aagcgcactc 85260 gttatatggg attgcctaac cttaaacgag caaacattaa aatgcaacta acccgtgaaa 85320 tagttgcaga atggaagaaa tgccgagacg atattgtgta cttcgcagag acctactgtg 85380 caattacaca tattgactat ggtactatca aagtccagct ccgtgattac cagagggaca 85440 tgctggaaat catggcggct aaacgtatga cttgttgtaa ccttagtcgt cagcttggta 85500 aaaccactgt agtagcaata ttccttgcgc actttgtctg ttttaacaag gataaagcgg 85560 taggtattct tgcgcacaaa ggctcaatgt ctgcggaagt tctcgaccgt actaagcaag 85620 caattgaact gcttcccgac tttcttcaac ctggcattgt tgaatggaac aaaggctcaa 85680 tcgaattaga taatggttca tctattggag cgtatgcttc aagtcctgac gccgttcgtg 85740 gtaactcatt tgcaatgatt tacattgacg aatgtgcgtt tattccaaac ttcatcgatg 85800 catggcttgc tattcaacca gttatttcat caggtcgtcg ttctaaaatt attatcacga 85860 ctacaccgag tggattaaac cacttttatg atatttggac tgcggcggtt gaaggtaaat 85920 ccggctttac tccttatact gcaatttgga actcagtaaa agaacgccta tataacgacg 85980 aagatatgtt tgatgatggg tggcaatggt cacttcaaac tatcagtgct tcttctcttg 86040 aacagttcaa gcaagagcac tgcgctgaat tccatggcac atccggtact cttatttccg 86100 gtatgaaact tgctaatatg gattggattg aagttactcc tgactcacac ggattttata 86160 aattcaaaga agctgaagca gaccacaagt atattgcaac ccttgactct gctgaaggac 86220 gagggcagga ttaccatgca ctaaatatta ttgacgtaac cacatctgag tgggaacaag 86280 ttggagtatt gcattctaat acaatttctc acttaatcct cccagatata gttattaaat 86340 atctaatgga gtacaacgaa gctccgatct atatagaact caactctaca ggtgtttctg 86400 tggcgaagag tctttatatg gatttagaat atgagaatgt catttgcgat tcaatagttg 86460 atttaggaat gaaacagacg aaaaggtcaa aagccgtcgg atgttctgca ctaaaagacc 86520 ttatcgaaaa agataaactc attattcacc atcgtgctac tgttcaagaa tttcgtactt 86580 tctctgagaa aggagtgtca tgggcagcag aagatggata tcatgacgat ttaattatgt 86640 cactcgtaat tttcgcatgg ttaacaacac agcaaaaatt tgctgatttc gtggataaag 86700 atgaaatgcg attagcatct gaagttttta aacgcgaatt agaagatatg aacgacgatt 86760 acgctcctgt agtgttcgtt gacgccgtga atagcgcaga atatgcgcct caagaacatg 86820 gtctttcatt tgtataaata ataaaaagca aacaacattg aggatatatc atgcctttag 86880 tctctcctgg aattgagctc aaagaaacga gcgtacagag cacggtagta cttaacgcta 86940 caggtcgtgc cgcaattgtc gggaagttcc aatggggtcc tgcatatcaa gttacccaaa 87000 tcactaacga agttgaactg gttgatatgt ttggtggtcc taataaccaa actgctgatt 87060 actttatgtc agcaatgaac tttctgcaat atggtaatga tctacgtaca gtccgtgtag 87120 ttaatcgtga agctgccaaa aacgcatctc cactggttga taatattgag tgggaaatca 87180 caactgctgg tagtaactat gaagttggcg acaaaattac ggttaagtat gcagaccaag 87240 tcgtagatga cactggttca gttactgaag tagatagtga cggaaaaatt aagtcggtgt 87300 tcattccgac atcgaagatt attgcatatg caaaaagcat taatcagtac ccagatttag 87360 ggtcttcgtg gacaactact attacttcac agagttctgg tgtttccgct gttattactc 87420 tgggcaaaat tatttctgat tcaacagttc tgttaactga acctgaaact gctcatgaag 87480 aaatgaccaa aaccgaattc cagactgctc ttgctaagta taaaatgcct ggaattgtag 87540 ctgcgtatcc tggcgagctc ggaaatcagt tagaaattga aatcgtatca aaagctgcat 87600 ttgataaagg tgaacagctg acgatttatc cggctggtgg aaaacgcgct tcgactgcaa 87660 aagctgtatt tggatatggt cctcagaccg atactcaata tgctatcatt gttcgtagag 87720 atggcgcggt agtcgaatcc gcagtattat cgacaagccg tcaagacaaa gatatctacg 87780 gaaataacat ctttatggac gattatttct ccaagggttc ttcacgctat atatttgcca 87840 ctgcgcaagg atggcctgaa ggctttgctg gcgttattcg tctgggtggt ggggtttcag 87900 ctaatgaatc agttactgct ggtgatttaa tacaaggttg ggatttattt ggtgaccgcg 87960 aagcactgcg agtaaacctt ctgattgctg gtgcttgcgc tggtgaaaca gatgaaatcg 88020 cgagtacagt gcaaaaacac gtttcgtcta ttgcagatga gcgtcaagac tgtttagcac 88080 tcatttcacc accaaggtca acgattgtaa atattcctct gacccgtgct gttgataatt 88140 taattgattg gcgtcaaggt gaaggaagct acgactctgc aaacatgaac atcaatacta 88200 cgtacgcagc aattgatggc aactataaat atcagtatga taaatataac gacgtaaacc 88260 gttgggttcc gttagctgct gatattgcag gcctgtgtgc tcgtacagat gatgttgctc 88320 aaccttggat gtcaccggct ggttatcgtc gtggtcagat tctgaactgc attaaacttg 88380 cgattgaacc tcgtcaagca catcgtgacc gtatgtatca agcaggtatt aacccggtaa 88440 cgggtcaagg taccggtgat ggtttcattc tgtttggtga taagactgca actactgttc 88500 caacgccgtt tgaccgaatt aacgttcgtc gtctgtttaa catgctgaag aacaacatcg 88560 gtgattcttc taagtggcag ctgttcgagt taaacgataa ctttacccgt tcttctttcc 88620 gtatggaaac aagccaatac ttggcgggta ttaaagctct gggtggtgta tatgacttcc 88680 gagttgtatg tgataccacg aacaacactc cagcagttat cgaccgcaac gagtttgtag 88740 cgagcttcta catcaagccg gcgcgttcaa ttaactacat cactctgaac ttcgttgcta 88800 cggcaactgg tgcagacttc gatgagttaa tcggaccaca gtaatatgaa ccccaggaca 88860 ttctggggtc atctaatctt tagatgataa attatattac cgcacacttt aatagcctct 88920 acgatgatgt agtcaatcga gaggctatat aaatatctat aggaaacaac gatggaatta 88980 acagacatca ctcgtgcgtt tgaatctggt gactttgcac gtcctaacct gtttgaggta 89040 gaaattcctt atctgggtcg taacttcagt ttcaaatgta aagcagcacc gatgccggca 89100 ggtatcgtag aaaaagttcc agtcgggtac atgaaccgta agattaacgt cgctggtgac 89160 cgtacttatg acgactggac tgttaccatc tataacgatg ataaacacga agtacgtaag 89220 gcaattattg cttggcaggc tcaggcccac gcccaaggca atgatatctc tggtatgact 89280 ccagctgatt acaaaaaggt tgctacggta cgtcagttta gtcgtgatgg aaaaactatc 89340 acaaatgaac acaccattac tggtctgtgg ccaactaacg ttggtgaagt acagatggac 89400 tgggattcga ataatgaggt agaaacgttc gaaactacct ttgctattga ctggtgggaa 89460 taatgttatg gggcttcggc cccgtatcga agttctgtga gttatttgct taaatatctg 89520 acaaaacttc gatataaata tacttataga taatttcgga gactccaatg gcctttcata 89580 ttttggactt attcgctccg tgggaaaaac gcgacgaagc tgaatataag caacaaatca 89640 acaatgacct agagtcaatc actgctccaa aatttgatga tggagctcgt gaagttgaat 89700 caaacgaaaa cgaaatccag tataattcat tcaaccaaat gatgtttggt tccaatgaac 89760 ctggaatgaa aacaaccgct gatttaatca acacttatcg tagtttaatg aataactacg 89820 aggttgacaa cgctgttgaa gaaatagttt ctgatgcggt tgtgtacgaa gacggtcacc 89880 cagtagtttc tcttgattta gattctaccg acttcagtca agcaattaaa gaccgcattc 89940 ttgaagaatt taatacagtt ttaacatgcc ttaatttcga gagaaagggc gctgaccatt 90000 tccgccgttg gtatgttgac tcaagaatat tcttccataa aatcgtcaac accaagaaaa 90060 tgaaagacgg aattcaggaa ctgagacgtc ttgacccgcg caacttacaa ttcattcgcg 90120 aaatcgttac tgctgatgac gctggtacta aaatcgttaa ggggtacaaa gagtatttca 90180 tttacgacac tggcaaagaa agttattacg cagatggtag attatattct gccggaacga 90240 aaattaaaat tccacgcgat gctatagtat atgcacattc tgggctagtt gattgctcag 90300 gtcaaaacat cattggttat ttacaccgag ccgttaaacc tgccaaccag ttaaagctat 90360 tagaagatgc gttggtaatt tatcgtatta ctcgtgctcc tgaccgtcgt gtgttttaca 90420 tcgacactgg taatatgcct tctcgtaaag cggcagcaca catgcagcat attatgaaca 90480 cgatgaaaaa ccgtgttgta tatgatgcgt caactggtaa gattaaaaac caacagcata 90540 atatgtcaat gacagaagac tattggttgc agcgtagaga tggtaaagcg gttactgaag 90600 tagatactct tcctggtatg tccggtatga gtgatatgga tgatgtccgt tactttagaa 90660 cagcattata catggcattg cgagttcctc tttcacgcat gccggatgca aataatcaag 90720 gcggtgtgca gtttgatgct ggtacgtcaa tcacacgtga tgaacttgat tttgccaaat 90780 ttattcgtag attacagcat aaatttgaag agattatgct tgatccactt cgcactaatc 90840 taattcttaa aaaagttttg tctaaagatg agtgggaaga cgaaataaat aatattaaga 90900 ttgtgttcca taaagactca tatttcaccg agttgaaaga tgctgaagtt atggagcgta 90960 gaatcaatat gctcacaatg gctgagccgt ttatcggcaa gtatatttct cacaagacag 91020 caatgaaaga tttccttcag atgtctgatg aagaaattga acaagaagcc aagcaaattg 91080 aattagagtc taaagaggct cgcttccaag accaagaaaa tgaagaggat ttctaatgga 91140 aaattatatt tccgcaattg aatccagaga cctcgtagca gccaaaaaag cttttggtgc 91200 aattatggct gaacggacat ctggtttaat tgaagagcgc aaaaaattta tcgcagcgtc 91260 tgtcatgatt gagggtgaag agcccgttga cgatgaagat gaagacgacg aagatgaaga 91320 taagtctgag aaagacgacg acgaagagga cgagtaatgc ttatactgcc tgaaaatcat 91380 gaattagtta tcgacgctgt cgaagctttt cttcctgaag cacaggcacg ttttgataag 91440 ttgtccgcag cgctttctaa agatgatata aataaaattg tagagaacat ggttacttct 91500 gagcctgatt tagcaattgc tttaggttca attaacgaat ctctacaatt aaatgaattt 91560 atcgttaagc acgttgattc taaaggtact attacccgta ccaaagatcg taaaacacgt 91620 gagcgtaacg cgtttcaaac aaccggactt tctaaagcta aacgccgcca aatcgcgcgt 91680 aaagcagtaa aatcaaaacg tgctaatcca tcggctcaaa ctcgtggatt acgtaagcgt 91740 aagaaagcac ttaaacgccg tcaggctctg gggctaagtt aatggaaaac ctcaatgaac 91800 aacttttaat tgagcattgg ggtcaaccgg gcgatgtaat tgatggtaaa cccatgctgg 91860 aatctattat cgttgaaggc gaaaatgaat ctggcttaaa acctggtctg tatatcgaag 91920 gtgtttttat gcaggcagaa gtagtaaacc gtaataaacg tctttatcca aaacgcattc 91980 ttgagactgc ggtaagccgt tatattaagg aacaggttgc tactcgtcag gctctaggag 92040 aattaaacca tccacctcgt gcaaatgttg acccgatgca agccgcaatc attattgaag 92100 atatgtggtg gaaaggcaac gatgtttatg ggcgagcaag aatcatcgaa ggagaccacg 92160 gtccaggtga taaattagcc gctaacattc gtgctggttg gattcctggt gtatcaagtc 92220 gtggacttgg ttctttgaaa gactcaggaa aaggatataa catcgtacaa gaaggctttc 92280 gcctgactgt tggtgtagac gcagtttggg gtcctagtgc tccggatgca tgggtacaac 92340 cgaaacaaat ttcggaaaat acctcggcac aagttgccaa tagtgctgat gatgctttta 92400 tggctctcgc agagaagtta aaagcgttat aaataattat gtaacttaac acaggacatc 92460 aaaaatgctt aaagaacttt taatgaccga agctaaaact atcgatgctt ccgtcgctct 92520 tgacagtatt ttcgaatcag ttcagctttc tccggaagct aaagctaact tcagcactgt 92580 attcgaagca acagtcaaaa aacacgccgt agctctggca gaatctcata ttgaaaagat 92640 tgctgagaaa gcagaagaaa aagttgaaga agaaaaagaa aaagctaaag aagaagctcg 92700 cgaagagctg aaagaagctg cttctaaata ctttgaccat atcgctgccg aatggatggc 92760 ggaaaatcag ctggcggttg accgcggtat taaagctgac ctgtttgaat ccatgtttag 92820 tggtatgaaa gaactgtttg ttgagcacaa tgttgtaatt cctgaagaat cagtagacgt 92880 agtcgctgaa atggaagaag aacttgctga gcaaaaagaa gaaactgctc gtttatttga 92940 agaagtttct aagcgtgatg cttatatcaa ttacgcccaa cgcgagtatg ctattcaaga 93000 agcaacccgt gaattgactg atactcaaaa agagaaagta gtttctctga cagagggtat 93060 ggattattct gactcgtttt caactaagct gaaagctatt gttgaaatgg tgcagggttc 93120 tgtagagcag tctgtaacgg aatctgccga tataaatact atcgacaaag aagcagacgg 93180 tttaaacttc acaactgaag cagtcgaaga aactcctgcg actaaaaccc catccgttat 93240 ggatgcttat gtagcccaag cggctcgtct ttcttaattt aaaaggttat acaacacatg 93300 aaaaagaata aacttatcga aaaatggcag ccgctgcttg agaacgaagc tctgccggaa 93360 attgttggcg ctagcaaaaa agctctgatc gctaagattt ttgaaaacca ggaagctgat 93420 attaatcagg ctccggaata ccgcgatgaa aaaatcgctg aagcatttgg ttctttcctg 93480 tctgaagcag aaattggcgg tgaccacggt tatgatgcac agaacatcgc agcaggtcag 93540 acctctggtg ctgtaaccca gattggacca gcagttatgg gtatggttcg tcgtgctatc 93600 cctaacctga ttgctttcga tatctgtggt gtacagccga tgtctaaccc aaccggtcag 93660 gtattcgctc tccgcgctgt ttacggcaaa gacccgctgg ctgctggtgc taaagaagct 93720 ttccatccga tgtacgctcc ggatgcaatg ttctctggtc agggtgcaac cgagaaattt 93780 gaagcagtta aagctggtgc ttctctggat gttggtgata tcgtagttca tgatttcgca 93840 cagactggtc gtgctcacct gcaggttgta acagccttta cagttgatgc tgctgctact 93900 gatgctgcta aactggatgc tgaagtcact aagcgtctgg aagctggcga agtagttgaa 93960 atcgccgaag gtatggctac ttccgttgct gaactgcaag aagcatttaa cggttcgaaa 94020 gataacccgt ggaatgaaat gggcttccgt atcgataaac aaaccatcga agcgaaatct 94080 cgtcagctga aagcacagta ttcaatcgaa ctggctcagg acctccgcgc tgttcacggt 94140 atggacgctg atgctgaact gagttcaatc ctggctaccg aaattatgct ggaaatcaac 94200 cgtgaagttg ttgactggat taactactcc gctcaggttg gtaaatctgg tatgacccag 94260 actattggtt ctaaagccgg tgtattcgac ttccaagacc cgattgatat ccgcggtgct 94320 cgttgggcag gtgaaagctt taaagctctg ctgttccaga ttgacaaaga atccgctgaa 94380 atcgctcgtc agaccggtcg cggtgaaggt aacttcatta tcgcttcccg taacgtagtt 94440 aacgtactgg cagctgttga tactaacgta tctccggcag ctcagggtct gggtcgtggt 94500 tataacaccg acaccactaa agcagtattt gctggtgttc tgggtggtcg ctaccgtgta 94560 tacatcgacc agtatgctcg tcaggattac ttcaccatcg gttataaagg tgctaacgaa 94620 atggatgctg gtatctacta tgctccgtat gttgcactga ccccgctgcg tggttccgat 94680 ccgaagaact tccaaccggt catggggttc aaaacccgtt acggtatcgg tattaacccg 94740 ttcgccgatt ctgctgctca acagccgaaa ggtcgtatta cctctggtat gccttctatc 94800 gtcaactctg ttggtaagaa tgcttacttc cgtcgtgtat gggttaaagg tatctaatac 94860 caataaggga gccttcgggc tccctttagt tgttttaatg gatataaata aacttataaa 94920 tccacagagg aaagcgcaat ggctaaaatc aacgaacttc tgcgcgagtc aactacaacg 94980 agtagcaact taattggtcg ccctaatctc gttgcattaa cgcgcgcaac cactaaatta 95040 atctataccg atcttgttgc tacacagcgt actaaacagc ctgtagcagc gttatatggc 95100 attaaatatc ttaacccaaa tggtgatttg acatttgcaa caggtgcaac ctatgcaggt 95160 caaatcggtg ccccggaacg tgagtcaatt gaagaactca ctatggcgaa taaagattct 95220 tttaataaag atgacatgtt taagtaccag aacgtagtct ttaaagtgct taaagacggg 95280 ccgtttactg gtacagctga aaccgacgaa tttggaattg tatctgaagc agtagcagct 95340 aataatattc gtatggtgtc agatgctgca gtcactgaaa aattcgaagg acctgattca 95400 gacccaatca ccgaagccag ttttaaaatt gataaatggc aaacagctgt taaatcgcgt 95460 aagcttaaaa cggatttaac tgtagaatta gctcaagact tagaagctaa cgggttcgat 95520 gctccagagc ttattgatga tttacttgct actgaaatgg cagaagacat taataaagac 95580 atcctgcaat cattgattac ggtttcttct cggtttaaag taactggcgt atctgataaa 95640 ggtgtattag atttaactaa gcaggattct gctccagaac aaggtcgtac tctgtatcgt 95700 ttcatttgtg aaatgaattc agcagttcaa cgtaatactt cttattctgg tacctatgca 95760 gtagcatcta ctcgttgcgc agcggtgctg gcagcttctg gttggttaat gcagaagaac 95820 gatgggacta ttccagaaaa cgcatatggc attctgaata acggccttcc actgtattgt 95880 gatactaaca gtccgattga ttacgttatt gttggtgtta aggcagaatt tggtgggaag 95940 gaaactgtag gttcattatt ctatgcgccg tataccgaag gtcttgattt agacgaccct 96000 gagcatgttg gtgcatttaa agttattgtt gacccagcta gcttgcagcc ttctgtagct 96060 ttactggttc gttacgcgct gtcggttaac ccatatactg taggattgga cgaggacgaa 96120 gctcgtgtga ttaatgctgc ggatatggat aagatggcag gaagaagtca gatgtctgtt 96180 atgctcggtg ttaagttacc taagctgatt gcggactaat ttatgggagc cttcgggctc 96240 cccttttttg ctataaacta aatatgtcaa acctcgggga gtattcctcc tcgagggatt 96300 taaacacttt cttatcatat agattaacac attctatccc gtgcctgcga gctatatcaa 96360 cagctactct cgtccctcca gatacactcc cgcatctttt ctcaggcgcc caatataata 96420 ccttatctac aggctcagtg cattctaggc ccaatacctg catagaattc cgtgcaaata 96480 atgtctgcac tattttcgag cattcgtccc agtacgacgt aacttctctc gccttaatga 96540 tgcttttgat tttggcttcg tttgataatt cagaccatac aacaacacct gtatcaggaa 96600 catggccaca aaagccagaa taaggaataa tcctacaaga atttgaccta tcgtatttcg 96660 ccaaccacgc ttcatctgaa cccggagctc cacctgaata tgaaaaatgc ccctcttccg 96720 agaggcgttg acctattgta gtcattagac tcagaactct gcgtggcgct tctcgtgaac 96780 caataagcgc caatctcatt attctaaaac ctcatgccat ttactacgaa tagtgttttg 96840 aattaaagta gtgatttctt tcttaacaac agaagggtta tcagcgaata gcatgtcatg 96900 accttcacgt gctgcttcgt taatgatatc tttcatagtc agtcccataa cacgaccgaa 96960 atctttagct gttacagtac caatatgaga cagaacgtta cttacccggt tccaggttac 97020 atattcggaa aagatttcca gaacacgctt atcattctcg gtgagttcaa ccttcgcttt 97080 aataggctta tcggatttag ccttctcgct gaacttagag ttcttacact taatagcaac 97140 acgagtacca ttattgaaga acttaggatg aaccggctta agaacatagc cttcagctac 97200 gccagtttca gaagaagcct gcggaccgaa cacatgttta tttgcgtgtt caaggtcagt 97260 cgtgtcaaca agctcattat agtaattgac aatagattta aagtcattca catattgaga 97320 tagctcggca aatgaacctc gaccaagaag tggagccaat ttaagaccaa gaccagtagc 97380 aaacgattct actacataat cgtcccaata aactttttcg ttaccggaat ccgacaggat 97440 atcaaatacg tagaaatctt tctcaccata atctacgcct ttctgaatac caccgccagc 97500 aaattcacca aagatttgaa cagatactaa atccatggcg ttcagcatat tctgcatttt 97560 agcgaaagaa ttcttgtact tcttcatgat aatctcatgg ccaaagaagc tttcaccttc 97620 taaaatagga ccagtacgct tagccggaac gatttcggta ggagtaataa tcacactgaa 97680 gttagtgcca tgaatcttct cacgagctac ccactcaacg gtatgcatat caaaaccagc 97740 accacgaatc ttctcgatga acttaccgtt gtaatgattc tcaagactag aatattttgc 97800 aaacattata atttccttag aatgtgattt tcataaagtc agtatcaccg ttacgctggg 97860 aactggtata atttgtaaca aatccttcat catgcaaata attaagaaca cttgtaatat 97920 gtttcttaac tagactgctc ggatacataa ttagctcacg cttacccgct aaagcggttt 97980 tctcaatctg agttaatact tcttcttttg ctgctgataa ttcttctgtg gctacgttaa 98040 tagcagtatt agccattcta tcggcaaggt tcataatttt tctctcaata aataaaataa 98100 aaccaggagt ccatctattt tggacaaggg taatggtatc agaggatttc ccctgagccc 98160 attataccac atcgattttt aaagcaatta atatccgctt ggaacaaagc gatacattaa 98220 tttgtcatgt ttatttcgca tgatttcaaa ctggttttta gggccaactt ctaatactaa 98280 cggaacattt acatccatta gcatccaatc aatttttcca taccgttctt taatcaaatc 98340 tgatattttg cgtgcgccat ttttataata agtgttatcg aatattcgag tcatcatatt 98400 atcaacaaat cttgatgcag aacgccaata attaatattg ctcgctgcag gagcaaactt 98460 gcgctctagg aacatctcaa atttctcttc taccttttta tctactttag acattataaa 98520 gtcctcatgt gtttaacaag tttcttatga cgagatttta tatcaacgtt tgttaagcgt 98580 tttcgatata caactttctc tttttgttta aaccgctcat gtgctttctc aacagagacc 98640 cacagcttag cggcttcggc tggagtgata tctaacgctc ttgcaatttc ttgaaaatct 98700 tttccgcttt catgcatcaa gtgagcttgt aatgctttca taataacctc atctatgtga 98760 cgaggacata ataaaccaat ccgtgaatag caaaaaaggg agccttcggg ctcccgaata 98820 ttaaggatag ataatacctg cttccagtgc agtacgatga acaatgtatc catttctaga 98880 ttcttgtaca tcgacttctg gataatcatc tagcatttta gctagagtat accgatgcag 98940 gtaataatcg ctgtcagggt cgtcgagttt ccaatctttg ccctcaacag tcattcgttg 99000 gatttcatcc attacccacc atccacacca gatataggct gttccacgga acggtagagg 99060 atgaatatac ggaagttctc cgtctggctc cggggctact cttttagtaa tggttacatc 99120 gccagtttta gtgactgtaa tcggggtgta atcttctgcg gaaacctcaa cggaaacctc 99180 aatcacttga gaccctatat cagacgtgtc aatcactaac gtgcttgttg agccttctac 99240 aggtgaaccg tctttagtcc aagaataaac cccagttgca ccttctggag caccgataac 99300 gttggcttta aaagatgcct cagacccttg ttcggccgta atagactcag gagtcaaagt 99360 aacagaaacc ccgctcatgg tctttttggt aatagttaca ttaccagttt tagtaactgt 99420 gacaggttta taatctggag cagaaacaac agccgaaacc tcaattactt gggacccgat 99480 agtggatgta tcaatttcta gagtgcttgt tgaaccatca acaggtgaac cgtctttagt 99540 ccaagaataa gctacagatg ctcctgcggg cgctccagta acagcagctg taaaagatgc 99600 ttctgctcct ttttcagcgg taattgaact aggcgtcaaa gtaacagaaa caccgctcat 99660 ggtcttttta gtaaaagcga cagcaatacc tttagttgcc gttccattat tatagtctgg 99720 agcagaaact gttacttcac aattaagcgt gtagctggtt tccgttgact cggttaaggt 99780 aattgtttta cccgtttgac cagaaataac agaagagcca cgtttccaaa tataagcaat 99840 gcttgctcct gacggcgcgc cagtaacatc agccgtgact acttgagatt ggccaatttc 99900 tttagaaaca gaagttgggc tcaaagttaa agtaatcgca ggcatagttt tgttattaac 99960 ggtcagagta gtttctgctt cagccgtttc aggatcgcct tcagccggag taacagtagc 100020 aactacttta acggtcttac tacctgcagg tcctgcagca acataattca tagctgcggt 100080 aacagaagat tgttttacac catttactgt ccatacaaac gtttctgtgc cttcagctgc 100140 ggctccagaa gttgttgcag taaaattggt tgttgctcca atgactgccg aagcagccaa 100200 aggagcaata gatacgctat aagccatagg tgttccttat tttaaagtta caaatgaaga 100260 attacgtgtt tcacgaatca taacagaccc gtttcttttg atgtaataga ttaaactaaa 100320 cagtgtctgg tgtgctgatg ggtgttcaaa cgacgttggc cgagatttcc agtcagggtt 100380 atctttaatc cattggtaaa tccaccatgg aagagtaata tatcctgggt tcttacctag 100440 caattgcatg tttggactaa agtttttagg aagctcaatg gtttcatcag ttttaacaat 100500 tttaactact ttgtccattg ctttggagaa ttcttcaggg tccatagtac taattggaat 100560 gtttgtaagt tttccttcat catcgatatg gataatgcta tctccaatag gagcttcagc 100620 ataaaatcct ttatcattga tagaaggagt ttttacttca aatccagggt catttacttt 100680 aggtgtttct ttataaaaat ctgggtcaat atcatgaatt ttaacacctg cacttactgg 100740 agcatcaaac agtagttttg cttcatcaga cgcttcatca ttgaaaagcg ctttgccttc 100800 aatttcatca tctgcttgga ttaaatcagc aattgataga ccatcgttgt cttctggcat 100860 aggctcatcg gccaatttag ccagttcttt ttccaaatca gcaaccatat tgtcaaatga 100920 gcgggtcttc ttcagtttaa taccgaaggt ttgggcatac tcatcgagct tgtctttagc 100980 ttctttttta tcgagtgcct gaatttcttt aatatagtct ttatctagca ttgggtgtgc 101040 ctcatgtaat gtataaatat gattgtattt ataaactgag gatagtacag tgcacgacat 101100 ccaagtcaaa tttaaagatt ttagtcatgt tcatattgag tgtgatgact caattttcta 101160 tgaactcaga gactatttta gcttcgaagc cgatggatac agattcaacc cgaaatatcg 101220 ttatgggcat tgggatggac gaattcgtct gctagattat aatcgtctct taccgtttgg 101280 tcttgttggc caaattagaa aattcgctga ccaattcgga tataaagttt atttcgatcc 101340 aactatattc gagcaagaaa ctctttcacg ggaggatttt gacaattggt tatcgactaa 101400 agaaatttat tcaggattaa ctaagattga gccacactgg taccagaaag atgctgtata 101460 tgaaggtcta gttaatcgac gtagaattct taatcttcca acgtctgccg gtaagtctct 101520 tattcaggca ttacttgctc gttattatgt agaaaattac gaaggcaaaa ttcttatcat 101580 cgttcctact acagcgttag ttgaccagat gattgatgat ttttgtgatt atcgtttatt 101640 tcctcgcaat gctatgttgg gtattcgagg tggtactgct cgtgattcga atgcattagt 101700 ttatgtatct acatggcaga ccgctgttaa gcagcctaaa gaatggtttt ctcaattcgg 101760 catgatgatg aatgatgaat gccatcttgc aacgggtaag tcaatttcaa caatcattgc 101820 gggtctcacc aattgcatgt ttaagtacgg actgtctggt tctcttaaag atggaaaagc 101880 taatatcatg caatatgttg gcatgttcgg tgaaatcttc cgtccggtat caacttctaa 101940 gttaatggaa gacggacaag taactgagct taaaattaat acaatcttct taagatatcc 102000 agatgcagcc gcaaatgctt taaaaggaaa aacgtatcaa gaagaaatta aattcatcac 102060 caacgttaag aaaagaaacc gttgggttgc taatctagct gctaagctag catcgcgtga 102120 tgaaaacgct tttgtgatgt ttaaacatgt agctcatggt aaagagctat tcgagatgat 102180 taaagctact ggtcatgagc aagtttatta cgtatcaggt gaagttaata ccgaaacacg 102240 taatgcttta aaggctatgg cagaaaacgg aaagggaatt attatcgtcg caagttacgg 102300 tgtattctct acaggtattt ctgtaaaaaa cctgcatcat gtaattttag ctcatcccgt 102360 taaatcgaag attatcgttc tccaaacaat tggtcgtgtt cttcgtaaac acaaagataa 102420 atctttagct actgtctggg atatcatcga cgacctcggt gtaaagccga aatccgccaa 102480 tgctaaaaag aaatacacgc atttgaacta ttgcttaaaa catgcattag agcgtattca 102540 acgatatgct gatgaaaaat ttaactacgt aatgaaaacg gtaaatctat gattaaattt 102600 gaagatattt atgaagccac aattcgtgag gctactatcg ataacttcat gagtaaaatt 102660 aatgcttgcc agaccttaga tggtctggaa gaactcgaga agtattacga taagcgctct 102720 aaagaaacta ctcttgctga ttctgatgac atcattgtgc gggatgcttt ggcggggcgt 102780 agacaggctc ttgaagccga ttctgaagat gaagatgacg aagacttcta atacaaaaaa 102840 gccccaaccg aaaggaaggg gcaaagccaa ttggctacat caacactaga ctaaattaaa 102900 agctgcgttt cttgtaattg ctcttctgtg tcttcagtga caggcaattc aatcgcataa 102960 ttatagcaag ctccgggatg aaccgggcct ttgtctgtgt ggacaaccaa tgcttcatcg 103020 attggtcctt tacagacgac acataccgta ttcgacatga ttgtctcctt agtttacagg 103080 tttatttatt acgcgccagc ttcaaactga cgaaggtcaa taatgtgctt aatgctaaaa 103140 cctcgtgact tgatagcatc cattgcatca ctacagaact ccaaaagaat tccccaatat 103200 tgcaatttag tatctacacc caagatttct ttatcagcgc ttaaaacagt tttcatttct 103260 gatttttcgt atacatccat gcatacttca ccaccaacct ctccacggcc agtgtaataa 103320 tccaatcgtg ctttaagatt ttgctttttg agggcatcta atcttaacat ctcttttcga 103380 caagtcgagt gcttacgcac ccatttacca tacagaacgg ggttattagc cgcttcatac 103440 tgtagtttag tctggtcgat aatcaaatca ttatccaatt catcctgtaa ttcttctaat 103500 ctcattctat ctccactcta ctgtttcttt ggaaggacta gtcccattat actctactgc 103560 tagagttagc attactacgc atctgtatgc gtatacgttc tagcgtatca gggtcgtcta 103620 ctatagaaaa ctgcacggtg acaattatag cgttatcgtc atataacgga agcacatcaa 103680 ctgatagacg attaatccta ggctcataat tacgcacggc agagactata ttacgcttta 103740 tcgtatcacc agttaatgga gtcatgtttt caaataattc gtttgtgata tcacaaccaa 103800 acgctgggtc aaatggccga gacccctttc ttgtggttat tattccaaga aggctatttt 103860 taactgatcg agctcctact gtttttgaca catcagtatc ccaagcaagt cgcatctctg 103920 ggtcaaggtc ggaatatagt ttatcgatat tactcatgac ataatcttaa agaattcttt 103980 aagcccctta attacatgaa tgtgagaaat tccgcattca caagtaatgg gaactgccaa 104040 ttgaacctgt ggcttcaata gcatattttt gatgttaact acatcttcgg ttgtaatagc 104100 agaatataaa tcatcgattt ctgcatcgtt taaatcatta aagtaaatct gctcatttcc 104160 aaccacgata taatctatgc attttgatat catcattgga atgtcggaat cgtcaaaaag 104220 attaggatac ttaaacttta tcttgaatcc ctttaagtca taccagaggt cttctggagg 104280 atcgatttgc gcatgtgtat aatttaatgg cacaggaatt ttacgcccac aggtgcaatt 104340 ccaggtcacc tcatgattaa cctcgcctat actgtgagcc caaagtataa ctataagtaa 104400 ttccgattct tgtttgttta acccagtagc attggtgcat tctctgagca atgctttaac 104460 gcattcatcg attgtaccgt ttttcttcgc tgcaattaaa ttagcgtatt cttctagtgt 104520 aaaagctcgg cactggatat tcttgccatt tattcttgtt tcaaatttat atgtgatgtt 104580 catatccact cctcttattc aattatttat aaatagtata aagaggatta ccttatggcc 104640 aacatagtta gatgcgaatt accagatggt gtccaacgtt ttaagccatt taccgtagaa 104700 gattatagag accttttatt ggttagaaac gacatgaaca ccaagtctga agaagaccaa 104760 aaacagctta tagcagaatt aatggatgat tattttcatg accatcctgt cgagtatcgt 104820 ccttatatat ttcttaaagt atttttgtca agtattggta aaactaaaat accagtcaga 104880 atgaagtgcc caaaatgcgg aaaatacaag cagtatcttt ttaatcttaa tcagcctccg 104940 ttgacaaatc cgaaagtaga ggttgcagga ttaacgctta agttcaaaaa acctatagaa 105000 ataattgatg atacaggtaa aatgatttta gacaacatta tatctgtgaa ggattcatct 105060 ggggaatacc agtggaatga attaagcgat agtaataaat tgacagttat cgatgctata 105120 gatgttgaaa ccttggaaaa gattttatcg cagatgaagc cgtttaactt tgagctaaag 105180 acgtcatgct gtgataccac gacagtatta aaatatgata acattgttga tatctttaag 105240 ctattgctac atcctgacga gattttcaca ttttaccaaa ttaaccatag attggtttct 105300 caaggtaaat atgacttgaa ttctataatg aagatgctgc ctattgagcg tggcataacc 105360 ttatcgctta ttgaaaagga ccttaaatca tgacaacaca aagattagga tatcctaata 105420 taagcataaa attatattct ggatatgatg catggctagc taatagattt gttgaattag 105480 ctgctacatt tattacatta acaatgagag attcattacg cgggactaat gaaggattgc 105540 ttcaatttta tgacgcaaaa aacatgcaca cgcgtatgaa tggcgatgaa ctagttcaaa 105600 tatctgttgc aaatagcaac acatcgagaa cacaaacccg aatttatggg attaaacact 105660 ttacagttgg tgttgatgat aaaggtgata gcattattac tcttcagctt ggaacgctgc 105720 atgacataat gaatctcaag ttcagcagag cgttttttag ttctgcatat gaaactataa 105780 aggaaatgat aggtgcaatg tatgttgacc aaccattgat tgctcctcct atcaacggaa 105840 ttaacgctta cgtcccacgg gttccctgga ctagtaccct caaagattac ttacgatatg 105900 ttagaaatgt aggcatttct acagacaacg atcaatttat ttttgcgtgg gaagatatca 105960 ccggaattaa catgatggat tatgaatcaa tgatatccca ggatccaaat gtattcatgt 106020 tcggggctcc tcaaacaata ggtcagtttg ctgcgggatt aaaatatcca ttagcatggg 106080 attttgaatg gcttgttaaa tcaaatagat ataatagaaa tcccatgaaa aatgcaacgt 106140 tttatgcaca ctcatttgtt gacaaagatg ttacccgaat tattaatgga gaaggccaaa 106200 acagcgtatt cattaataga tcaggcggat attctgacat gatttttagg aatggctatg 106260 aagaagcact acgcatttct acgatggctc aatatgacgg gtatgctcaa actaagtgtt 106320 acggtaattt tgaactaact ccaggaatga aaatcaactt tgttgattta aaggaccagt 106380 tcagaactga cttttatata gatgaagtta tccatgaaat atcaaataac acatctataa 106440 ctaacttata tatgttcaca aacggctctg cccttgaacc tgtagatttg attaaggtga 106500 aaaatgaact taaacgtgat tcttcctatt aagaaaatag taataaatga aaagacgata 106560 tcaattccaa aactggggtt aaagcaccat aatctgatga aagatgttaa gggtccagat 106620 gaaaacatga atcttctttt ggattcaatt tgtccaggat taacagcagc cgaatctgat 106680 attgttgtat tacatttatt agcatttaac aacagaataa aagaaacggt tgttaaagat 106740 gattttacct acgatttgaa taaggtttac atttgccagc gattaactca aaggttagat 106800 ggtaaagaat tcaaattcag agctcctcct cgttattcca aattaggttc agtagattca 106860 attttaagcg aatttcttga atcagtagat ggaaaaccaa tggatataaa ctttatgaag 106920 cttccagctt ttgtaacaaa gtgggctgat gacttagtaa acactatagc cattgatgga 106980 cctgaaggac caatcaaagg catgcttaac gtaatggaaa tatttgaatg actaagaaat 107040 cagaaatgaa ttcaatgcgt agaagagtta ttgctgactc ggctccacag aaaaaggctg 107100 agtctcaagc tgatgctcag attaatacgc tagaagatat tggtcgtcgc ttagacgacc 107160 agcaagcgtc tactgatttg atttcggatg taatagaaac taaatcaaac gaaattatca 107220 aatcagtaga agatgtttca gctggtgtcg aattgaccgc agaagcttca gaacgcacaa 107280 cagatgctgt ctcgaaatta aatgatactg catcgttaat taatgataag ctcacgaaac 107340 ttgccgactt gttatctaaa aagcatgatg ttcagcaaga tgtccaaaag actggcactg 107400 gaacatcatt agaaacgata acagaacaag tcccggatgc tcctactcag cagccattgg 107460 aggaattact tgaaaggctt attcctcctc aggatgacag acgtcctgac gcggatttct 107520 ttcctagcac agaagagcaa gaggaaaaag ctgagcctaa aaaggaaact gaggacaaga 107580 ataaaaagtt tcttgacttg aaatttggag aattaattaa aagcgttaaa tctggttttg 107640 gaaaaaccat ttcattaaca gataaaatta gcagtatgct gtttagttat actgttagcg 107700 ctttggccca aatggcgaaa actgccgcca tggttttggg tgtgataatg cttatagatt 107760 taattaaagt tcattttaat tattggacta aattattcga aaagaacttt gttgaattta 107820 acaagcaggc taaagaatgg ggtccgctat taactgcaat aagcgagatg tcgaatgaaa 107880 tagtaaaatc attcgtcaaa ggagattggg gtggattagc aaaagccatt ggctcgggtt 107940 tggttgatgt aattgacaag ctcggagaaa ctattatgct cggaatgagt aagcttcttg 108000 ctggaatgtt acgcgcatta ggatttaacg attcggcaga taacattgaa ggcgctgctt 108060 tagacagatt tcaaactgtt actggggcag aactcgatga agaagatgct aaaatgagag 108120 caaaatatgt tgaccgtcaa gaaagagaat atgacgaaca acctgaatgg aaaagaaagc 108180 tttctgctaa gttccaaaaa ttcaccggtc agattgatga cgatgaatat aacaaactgc 108240 tgagcggaga gaaaaagcag tcagcgtatg cagacttgcc agaagacgaa cgcctcaaaa 108300 tcatcacagc tcgtaataat gctgaggcag aactcaagcg tacaaaagca tatgttgaaa 108360 aaactgacgc atctgattcc actcgattag actctgctaa ggatgcagta caaagcacaa 108420 ctactagata taaagaacta gagaagttat ccccagaggt tgcaaaagat ttaaaggttg 108480 aattagacca attgcaaaag cttcttgatt ctaaaatatc agaacctgct ccaactgccg 108540 aagctatacc tgcagcagaa caacctgagg ttaaacagtc tgcttctatt aaagccgccg 108600 cggatagtcg tgaagctgct cgtacacgtg aatctaatac acagtcacaa cctatccagg 108660 ttaatactgc tgtaaataag aatagcacac atgtttatag aatgcctcca cagacttcga 108720 cagctgctcc tggaatgcaa ggcgctatga aaacctctta aggaaaaata atgatttttg 108780 aagaactggc cgatggcctt gaaaacatca aaaaatcagg aactcgaatt tcccaaggta 108840 aatctaaact gacgaatgcg ccaaccacta aggtggcgca gttcccagct gaacgttcag 108900 ctgggaatga ttccgcccaa gatatgagag tacatgactt atatcgcaac gggttattat 108960 tcacagcata tgattttaaa ggaagaacta ctcctgattt gcgttcattt agacgagatg 109020 taatgttatc gtctgtattc gattcaccaa tgtcagcatt ggctaattca tcaagctcta 109080 ccactagtac tgcaccagta gctaatattc tattaccgcg gtctaagtca gacgttgatt 109140 cagttagcca taaatttaat gatgttgggg attctcttgt tacgcgtggc ggcggtactg 109200 ctaccggtgt attaagcaac gtggcttcta ctgcggtgtt tgggtcgata gagtctttaa 109260 cgcagggatt aatggccgat aatggtgaac aaatttataa cactgcccgt agtatgtatg 109320 ccggacctga taatagaacg aaagtgttta cttgggattt aactcctagg tctgcagatg 109380 accttataca aattattcgc atctatgaaa tttttaacta ctattcttac ggtgtgactg 109440 gaaattcatc atacgcaaaa gaagttaaag ctgctattga tgaatggtat aaaggaactc 109500 ttaaatccgc agctccagat ggggctaaag tagaaaacac agtgtttgag caaataacat 109560 cgtttttaag taatgttatt gtagtttcta acccaactat ttggactgtt cgtaattttg 109620 gatattctac atcaatggat ggtagagagg atatatttgg tccatgccaa attcagagta 109680 tccgttttga taaaacgccg aacggacatt tcaatggttt agcaattgct cctaaccttc 109740 caagcacatt tacgcttgaa attactatgc gtgaaatact tactcttaat agaggaaacg 109800 tttatatcgg aggtattgaa taatgtttac tctcgaagaa tttaagagtc aagctgctga 109860 tatcgatttc cagagaacta acatgttctc tgttgtattc gctactgtac cctctagtaa 109920 aacccaggct cttctaaacg actttggtgg agagctgtat aataatatgg gtttagatgg 109980 aaattggctt ggattgacac caggtgaatt caatcagggt ataacaacta tagtgacaca 110040 aggaactcgg caagttgttc gtaaatcagg tgtgaataca tttatgattg gcgcaatgac 110100 tcaacgtgtg gtgcagtcat tattaggaga atttacggta ggtacttatc tgctcgattt 110160 ctttaatatg gcatttccaa cagcaggatt gatggtttat tctgctaaaa taccagagaa 110220 cagattatca tatgaaatgg ataagttcca taacgctcct aatataaaaa tcacaggaag 110280 agatatggaa ccgctggttc tttcatttag gatggaccca gaagcaagca actaccgggc 110340 aatgcaagat tgggtaaatg ctgttgaaga cccagtgact ggtctgcgag gattgccaca 110400 agacgtagaa tgtgatatcc aagttaacct tcatgctaga aatggattac ctcatactgt 110460 atgcttgttc tcaggggcta tgcctgtagc gtgtggagct cccgaattta catatgatgg 110520 agaaaacacg atagcagtgt ttgatgtcac gtttgcttac cgtagcatgc aaacaggttc 110580 ggttggaaaa caagccgcta tggattggtt ggaagataag gctattcaga aaattgagac 110640 gattaatcca aatcagggct tgagtgcgtc tgcttcaaga ttatcgcgtt taggaggtgc 110700 aggcggagga ctttctaata tcactactac aacaagtaga ataatttagg ggccttacgg 110760 cccctttgtt ttatgcaatg cagccaataa accctggctc agtgcgaaga agtttcattt 110820 ctttagtagt ccaaactact ttaacgggaa tgataccttc tgcttttccg ttaagaacgg 110880 cttctacaaa cgatggctct gttggcttgc gaaagatgtc ttggataaga accgtcggag 110940 taccttcgtt aaacccttca agcatgataa gaacttcttc gttgaacttc tctgcatctt 111000 taacatcagc agaccattca ataccattaa agcggaatac gtgtttcata tcaatttcct 111060 cattggtttg tgtaagtcta tagtatcacg tccttgtgat aagtaaacaa ctttatgcaa 111120 gtttttctgg gataccatcc aggttgatag caccagccag tagctccatg gtacgtgtgt 111180 agctaacctt atctgtagaa cggtctggag agaaataaat ctcgtttaaa aagcctttga 111240 acttgctttc ttcaagaggt tccactttgc cttgttccat caagatgtca ccatcataga 111300 gatgaaccga ttcatcgatt tgctctggcg gaactaccgt catttctacc atgaatgtct 111360 tgttattcgc tacaccaact ccatttctaa aaggagttcc ccatactttg ttgactttca 111420 ttgccaaccc gcgaggaaga ataacttcag cctcatcact aaaacttgat aagacacccg 111480 ggataactac cttaacttta tcagccccat gaataatgaa cccaaactta aactcatcac 111540 cataggcaac ttcctcgcct ctatcaactc tttccaagtt gtctgttcca ataacagaag 111600 ataccgcatc gatagttgtt tctttgtttt ctaaatcaga actaggtgcg tctggcatta 111660 atgaatcacc agcatttgaa taagcaccaa agataattgg acttaacgaa gtagaaacat 111720 agttctggaa ataaaacatt ttagactcaa tgttatcttt aaagtcttca tattttcctc 111780 gctgaccacg atacaaaaga gtgcctggtt caagacgcaa acctttttca aaggcagaat 111840 cgagcggacg aattttcttg tcaataatcg gatcgcctaa gctttccata ccaataagat 111900 agttattaac aaatgaataa ccagaaccgc agtaatggtg tattgcatct ctttcttctt 111960 cgcttaaacg agattgcatt tcacggttat attcaattgc tttggatata gaatcgccaa 112020 caattgacac ataagcggat atcatataat tgacaagatt ttggtattga cgtaaagctc 112080 cgaaatcgtc agctggaggc atatcaaatc cacgagtagc tacttcaacg attttacgca 112140 ttgtttccat agatgcagga tttttagctt gagcaataac gtcagcaacg tctgaaattc 112200 gttgttcagc gattttcatt ttgtctgacc ccgaaggaat gaaaaccttc cagtcgtcat 112260 gcattctcga catttggcct acaaataatc tctcaactgc atcgccaaaa ttacttccat 112320 atccgccacg aacacgatag tgcttgatat catcaacata aaaaggaatt gatttttcta 112380 acccggattt aatatccttt tggaggtcta ccgtatcgcc ttctgcgttt agtactggag 112440 tgttagtagt taattcgtac cagcgttcgc gtttattttc tggccaatct tcatcaacat 112500 atgaaacaaa tttaccgtac tgtgctcgga ttaaatcttt tcgagacact ttcattttac 112560 tcattacagc gagttcagat ttcttgtctt ctttttcgcc aatggaatta gccaatgctt 112620 cggctttggt aacgttttcg ccggtttctt tagacacata aacttcgcct actttggatt 112680 caacctttgt gtataactca tctgaaattt caggaattcc ttcaatctct tcaagcttct 112740 tacctttgcg aaccataatg gaataagcat acttaccttt gtagtaagcc atatctttca 112800 ttagattgaa ccgaccaccg gtgcgagtag taatcaaccg agcaagaata cgctggatag 112860 ctttatcttg tccttgcatt ttctttggat taaagcggaa cattaccgca tcagctttaa 112920 tttgcttaac tactttgttg acggtctcaa aaatggtatt gatagcacca atcgggtctt 112980 ggcctaaacc acctttaagc gcaccgatgt tacctttttc cgacacagag aacacgtaga 113040 cctggatgaa tttatcaccc atcttgatgt tcttaactgc atcaccttga cctgaccctt 113100 gtactaaccg aatcattaaa ttgttattac ccggcacctt aatcaaaaag acctgtggta 113160 ccttaagttt tggcttaacg ttctcgacag gatagatttt actattctct tcatcgaaaa 113220 cttcatttaa aagttccatg acatatcctc gtttgtttat tctatttata cgaaaaaagg 113280 cccgaaggcc ttaattaatt attgttactg tacgccaaac ttgtagtcca tttacagact 113340 catactcttc aatgttttct ttgaagtttc ttaatgtgtt aatgttatta aactcaagaa 113400 cttctgtgtg aacagaaata ccaccacgtc cgtcaagaga tttagcaatc acttcgtata 113460 aaactttcat tttattcctg ttgcctcagt aaagttaaca ccaaacgcgg cttcgaatgt 113520 attagccact tctttatcat atctacgctg tttaatgata ggtaagaata atcctactgt 113580 accatcatca cgaccttcag cagttaccca accattgcat tcaagttccc agatagttcc 113640 tggaagagaa tctcttagct tccataaatg agtacggtca agttcatgta attcttcagg 113700 tttatcttta agaccagagc ctgcattaac tcgaatacga ccacattctg atacgaacat 113760 taacccaccc attttaccgg gttgtttcct atgctcatat gaaccaacac acttcaaatc 113820 gacagtgata acctctttaa atttaacgag gttcttagaa cgcttatctt cccaataagc 113880 accgatattt ttaaggatga taccttcgag accttggtct acgtatgttt tgtagatggc 113940 tctagcttca tggatgttat gtacgacatg gttttcaatt agaataacct tgtcatagcc 114000 tttgctcatc atttccaatg cacggaagcg tacatcataa gcaaatccag gaactttacc 114060 ttcggaatat actacatcaa gcggaacata atcccaaact tggaatctca taccttccgc 114120 ttcttcagca gagattgttc ctttaatggc cttattagcc aatccgtttg attccgtgcg 114180 agccgtctgt tggaattcct tagctttact taactcagga agctcaggct ctttaaacat 114240 gtcaaacagg tcgtttgttt cttctttcac ttcgacatga tacaccaact cgccatcaat 114300 catcacacca ttaggatggc gttcgcgggc ttctttggtc atctcgataa gttggcgctt 114360 gagtttatct agacctaggt attcattacc agaacgagta agaagagtta catcatctaa 114420 ttcatctccg cggatttcag cgaagcatcg ggctccatca gctttaagtt gtgcgaatgc 114480 agggaactta atatatgaca atgctttctc agaataggct gacgccaaca tctgtggcat 114540 ctcaggaatt aatttcttcc atactttatt agcaatagaa cctgaagcgc cacaccgcat 114600 atctttaaga agaacccgta ccagtacact agcatcgccc tcattcatct tagagagcaa 114660 atctactagc ccctggattg ccatattacc agtaagtact cgtgctgcca gaatgtcttg 114720 gaggtaatct agaccatctg aaaacgtctt tgaaggaaca tttggatatt taacgggagt 114780 atattctgga actttcttaa taaaaaattt aaatcgcccg gaatacgcca gcagataagc 114840 tcgctttaaa tcaacgttat ctttattgtc aatgagaatt tgggttttgg ctttagaacc 114900 cttagcatct tcaattgctt tgatgatatc aaaaatcatt attcacctaa ttcttctgaa 114960 agttcgctta cactacgatg ataagttaat ccatcaatat aaacaaaccc gttattgatg 115020 cattcattcc aaatcgggca cgactttgct tcacgccaaa ttggattcca acgataaaac 115080 tgattaacat gaccataatc acatgataac cagcgtttac ccaccttagt atgaactaca 115140 aacatatttc ctcctagggt atggctatta taccataccc agattgttag caattaattt 115200 ggtggttatc acatgtaata cgaccgttat tccaccagtc gtttccagga ggaacgtgcg 115260 gaccaggact aaacggaatg ataggttgtt tccaccaatc tcctggaact tgtcgtggag 115320 gccaattaaa aggatgctgc tctttacgaa tttggtcttt gatagcttct tcccacaatc 115380 cagaaagaga cttctgaggt ttcttaacgg atttcagaga ttccaggcaa gttacaattt 115440 gatgccaatc ttcaaccata attccaggag cagtcactga accttctcgc tcgccgcgag 115500 gcatatagaa cacacgggtt tcagtatctt caaagacttt gctggcggca gcaatatgtt 115560 taggcaaatc gtcaacataa catacaatgc gatcgccgta ttttacttta gccttttcca 115620 gtaaagcatc tttagattca tcataatcgc agaccatgat ttctgtaaat gcatcaggga 115680 acaaagcatt cagattgaaa cgacgattaa ggttagcatc tactgaatta ccaagagccg 115740 tgatagcgac aaaatcgtat ttttctttga gcttattaac tgtagctaaa gcatcagcat 115800 acggagcaag ataacgaata aaatcgctgt tgttatattt cagaagcagc ttaacagcca 115860 gttcttcttc acaatcaaac agctcagcgg gtttaataaa tttttcagta gtcatcatat 115920 caaggatgtg ctctaccgga aggttatatt tttgggcaaa gtaaggcaga ccactttgcc 115980 acttaacgat gattccatca acatcggttg cgattactgg ctttgacatt cggggaaatt 116040 cctcaatgct tgtttaaatt tggcgacgct atttgcggca ccggtgaaat tgaaccagat 116100 taaccctgga gtgtccgagg gttctatatc aattaattct atattataat actcagcagt 116160 ctttagcatt tccctggtga tacgtcgggc aaccatatga ccgaaatgag gattaataga 116220 catcgtcgtt agcagccctt aattgagtaa tcggataaag ctcagattcc gcatgaattg 116280 aacgattgcc atcaacccag ttgacttcat accaaggctc aaccgagtag gctttaatgg 116340 ctggagccgt gtcacataca actccaggaa ttccatttgc taatcttact gtactgaaga 116400 tatgatattt catgcatcaa gtctcactgc ccattcgggc aattcaaaga aatccggagc 116460 atcaatttca tactcaacgg tgtgttgttt aacatcagct gacatgatat caaccattgg 116520 gtggtttttc aaactgcaag aaaaaatacc agctttagat ttaggcacgg atacaatcat 116580 gatgatttcc tcaaaattta gttatgaatt tttctttcgg cattttggca tttgagccat 116640 cactgtcaga atacccaatt ggcatagttg cattaatgaa ttcaatttta gcatttataa 116700 cattaatgct cagagaatct acgccatcaa ccatacgaaa ttcaggaggg caatatttat 116760 caatgtatgc tttcacgcca tttttattag caggtgtacc atcgcgagta tcgctgataa 116820 tggtttcaac ttttttcttt cgtgaatcat agaaagctga tacaatcatt tcaatttcct 116880 cttaaaacgg acgaatatta acgtgaacca cagggacagc aaaaggttgc atgattacaa 116940 cttttgtgtc tttagttgca ttcaggcgtt gtacttttgc aagattaaca gcttcttcct 117000 ttgtcaatcc acctttgtag gtatcatttc ctttatttga ggtccaaaca ccccaatcat 117060 tgcttccatc atcggtcttc ggttcaggtt caggttcttt gtagatggtt tcttcaaaat 117120 aatgctgaaa ttcttgatta gtaagaatac accacatgtg agaaaagcga acttcatcta 117180 cactaacacg tttgtattct ccatctggct taatgatttc aaattcaact aatccggtat 117240 tttccgcata tttaaaggtt ctggtaattt taatcggatt attaccgatt tgctcaaaaa 117300 cacccttgat aagagcgcct ggagacaaga ttggagtctt tttaagttta tagaatttac 117360 ctttttccat tatcatttcc tcaatagtgg ggccgaagcc ccgagttagt taaaacttga 117420 tttcctttga aacgatatcc cagattgctt cacgttgttc ttcggttgtt ttacgaccga 117480 ggatgtggcg cagataaatt ttaacaagca gctgacgatt tgtgttccaa gacggatgtg 117540 aagataaatc acgtttacga acttcatcat gaaatccaac tttgatttca gaaccattga 117600 actgaatatc cagagtagga ccgttttcaa agctgaagaa tacgtagtta tcttcccagt 117660 acatatcaat ttgagctact gtgccattgt tgtgttccca aagcaaagta gtagatacgt 117720 cccaagcatt gttctgtacg tatttgcggt tgaagttagt gaagttcatt tttattctcc 117780 gtagtttgtt atctgtttgg gtggtacagg tctatagtaa cccagaccac ccaagaagta 117840 aacaactttt attcaaaaac tacatttatt tcttgttttt ctgctcgagc agtagaatgc 117900 agtttaaaaa tctggaactt atattctggg tcatgcttga taactttcgt tacatatttc 117960 ttggcttttt caagagtgaa caagtttgag ttgtaatcac cacgaacaat accaaattcg 118020 ctctctttct ttccgccgac gatgatgtat tgcgcgctgc cgtcatcgtt aacttctacc 118080 attccgcttc ggagctcgta cttagtaaac atgatgcaat tactaaatcc tagcatatcc 118140 gcgtctatga tttcacctgt gctttccagc ttaattgatt taacattacc atgttccgtt 118200 aacgtatgaa ctgaccacgg catgcattca actctttcag caataagctt gttaacgtta 118260 ctactggttg aaagatactc attctttgca gcttcggtca aacggtagct tttattcatt 118320 tcaaaaactt cagacatttt taacctctac agttttaaca gtttttactt ctgcaaatcc 118380 gatgctttta aacagttcat acttggtagt ttcggggacg atatcggtta gctcaaggat 118440 gatttctttt gcttctttta aagtgaagac gctacgccca tctttaacca ctggagtagg 118500 tttaacgaac gttgacggga tttcaaaaac tgcataacgg tcatcagagc tttggttttc 118560 aaacgctcct atttgcacaa cctttccttc ttctaactcg tgagaagaaa ataaacatga 118620 cagagaccgg tcatattcat ctcctatggt ttttgccgaa atgattttac cggtttcggt 118680 tttaatctta acgacccgtc ccagcgaatc aagttctaac ggcgtccagc cttgaactcc 118740 gacaacggtg gcaatgagat agttaattgt gttcttagcg tctttccatc tacggtaagt 118800 ttctggggaa atgcaatata ctcggttttt gctgtaattc attttgatat cctcaaagat 118860 ggggccgaag ccccagtcaa gattactgtt tagtccagtt atccatgttt aatttaccga 118920 cctttttcat ttgctcaatt aaagcatcgg cacgattacg accattttca taccaggtta 118980 catcttctga gtaaccgtct tcttcatctg tgtaagtttc agaacgaata cgaccaacaa 119040 ctggagtgtt cagaacatat acagaacctg tgaaccaatt agttagcgtg atatgccagc 119100 agaaatcatc tgacggtccg tccggtgtca tgcatggaac gatatcacct tgaactttag 119160 acaaaatcca cattttctca tggacagtct gagctttgta accgtcatgg tctttagtct 119220 tgatagttgc gttcaggttg atggtattca ttttattctc cgttgtccgt ttaggtggta 119280 caggtctata gtaaccttgt tgagcctaga agtaaacaac tttttttcat tctgtggaaa 119340 ataaaaaagg gactcccgaa ggagtccctg aacttatgct ttcggcttac caaaacgaga 119400 agcatcatcg cgaagaaccg cacgagcccg acgcatgatt ttctcaaccg tctgattgat 119460 acgcttgttc gacccacgct tgtagccagc gcgtttagag gtaccaacaa cttcttttac 119520 tgcagttttt gctttagctt gtttagccat tttatcatct tccattttgg agaaatacat 119580 gggagcacgt tcttccgagg ttcaacttct ttcgacagtt ctttcggttg tagctcccgc 119640 aagcccctaa gggtacgatt aaactcttat ctgttgcaca ccgttagctt aaaggttccg 119700 ggtctgattt ctcagggata agatatacac cgatggatgt ataggccttg aggcgtactc 119760 ccgattggcc atcgcctcgg ggtagcatgc acttgccgtt tatttctagc tgcactttgg 119820 tagcaaatca ccgatggttt cggatgtttt acgtggggat aaccaacaac gtccacatca 119880 tacgttaccc atgcgtacac atggtgggcg tacaaattac ttcagcgtta ccacaaagtg 119940 gcgaacagct ttgcgagcag cagaaccaag atgcttagca tacttcagtt catccatcgc 120000 ttctaaagta tcacgaaatt cagcttgagc tgggttcaga tgtttaaaac ctttcagaac 120060 ttccagtgct tctgcataga tatcgattga agcaccgtag ttttcgtgac cggaattcca 120120 tgcattacgt tggagttcca gagctttagt aagttgtttg ttcattgaaa cattcctcaa 120180 atgaggttaa aatttggtgg acggtaaccg aggtttagct cgggcatcca ccgcgtagaa 120240 ttgctcgggt aactaattgt ccgacgccca attcatatta ttatttatac acacaagcta 120300 gggacttata atgacaagtc acaaacttct gtttaatttc tttaggtttc ttcacacctg 120360 ccgctaccaa tggatgcggt acatttctaa tattaccaac aggcagtgga gtcaaatcac 120420 cgacttcaac aaaacctttc ggtacatcat caccgataga atagatttca cacatatcgg 120480 gaagttggcc ttgttcttct tttccgagaa taataccgga aggagaaaca atttcatcac 120540 ctttttgtgc aggttcagac acgagaatta catactcgcc tagagcttta attggaagtt 120600 ccatgtgtta cctttattgt ttgaccatgt agttatatta acatggtcag tttaaagcaa 120660 attacttacc gatcatctgc agcagatgct caactttcat accatttacc gagatcagtt 120720 tatcaaaggt aaatgagcgc caaccttctt tctcggtatc atataccgga agtgaagtag 120780 tgctttctgc tcgggcagat ttagtagtac tttctaccaa atcagatgga ataatatctt 120840 tatcacgagt acagcgcaga gtacgaatag tgccatcagc tttttcaaac acaatctggg 120900 attcgcccat gctcagcaca gccttcagag tttcacgaat atggatgttt tgttcagtag 120960 tcagtttcat tttgatgtct ctttaatagt tttgataatt acagatttgc gcttggataa 121020 ttcttttaat aatcgaactg cttgatcttc aaatttaaat gttgctaatg gtttccattt 121080 aaaccaacac cggcgttcta ctgagtatga tataacaaca tcaccgctta ggttaagttt 121140 attaatttca acaattctaa gtttcattat tcaattccac agaattcttt aatgttatac 121200 caattcaact tatccaaatt acgttttgga acattgaaca cctcgattcc agcagaacga 121260 agaatatcgt cccaaccggg ttcgttcttg tcgtatgttt cacagtatac taatttttta 121320 ataccagact gagcgatggc ttttgcgcaa tctggacatg gagacagtgt gacatacatt 121380 gttgctccat caatactact gccgttccgg gcagcaaaaa gaatagcatt aagctcagca 121440 tggatttcat tgactttaga ccatgcagag tgggctgctc gatgttcttt gagcaatccg 121500 acttttttga cttggaatcc gtcttgacgc aatcccgtag atttgtaagg aatttcacca 121560 atccaacctt gttctgctgc atggtcacaa cagttcacac caccagaagg tgaaccgtta 121620 tagccagtag aaataattcg tccattcttt tcaattactg cgccgacttt ccacgagcag 121680 cattttgact cttgagatac gagatacgca atttgtagta ctgtcgacgc tttcatttaa 121740 atcaccagat aagttgtgtt atttgtttta accaatttta actcgtcggt aggagaagca 121800 aaactctcta ctcgagaagt acgaatgcct gtaccatctg gaaacggatg atttcctcgt 121860 tcaagaacat cagaaaagac atagccataa agaggttggt cttccttaac atcaacgtta 121920 ctgtacaaaa tagcatcata ttcttcgcgt ggaattgacc aaacaccttg gtcagaacca 121980 ataacagcat taattagacg aataccattt tggctaattt ctgctttaat gccacgagca 122040 tgttcaatta aaagagcttc tacagcctca cgtaaagtca ttagatatgt cctaaaatgt 122100 tagtcatttc aacttggcct gttccggtta aagccaattg agtgtgttga ttgctctttc 122160 cattattaac tgtaatgata taagcatcaa catagttaaa ggatgactct cgtcggagag 122220 tcactttact tccaggaacc cggtttgcta cttcctgcgc gaagatttta accttcgaaa 122280 taaattcatc atgtgaaaat ttagcgtcag acaacataag tctcaacctg ttgggtttca 122340 aaattagcaa taattccaac gataaaccaa tcgtgttcac cttcgccaca agaaatttta 122400 acttcagatg aaccgcctga ccggtcaata gaaaatttaa taacttcgcc gtttggaata 122460 agtgcattca tggcagataa aaactctgca tgcattttgg ctacttcaga tggagtaaac 122520 tcatctgtta aatgattagc aacaacttgc gtaaatgata cttttactac ttcggaatac 122580 tttggaaaca ttatactttc ctctaaaaat caccgtgggc tacttgccag cattcaacac 122640 caatacgacg ccacatttca actacctgcg ccctgtcatc tactgcaagt ttgacattat 122700 aacgatcagc aattcggtcc cagaagattt cttcttttac cacatcgtct ttgcgtgaat 122760 cgccttgctt acgttggaag tgttcgcctg tttcgccaac atggtccaac agccatttct 122820 tcgtaatgcg ttgataaaca gtagggtctt ctttagtacc agactctctg ccggaaacag 122880 taagaatttt atatcctttg ttacgaagca ttttaagaaa ttcaattacc atttcctttg 122940 gatggtcttt accgcatttg gccaagtcat aaggagaacg atgattgtta tctgctaacg 123000 ttccgtcaag gtcaaagata actgcttttg gcagtgattc gtctggaatg tacaaatcat 123060 atgggtgcat cttagaatag aagctacgaa gcacttcaat aggaactgca ttcgcgccac 123120 gatagaggtt acgattaagc aattcagtcc aaggaacgtc aaagcgttta atttcccact 123180 tgacaccatc aatttcgtat gccaactctt gccacttctt gatagtcgtt ggattaaggt 123240 tagtatcagc aatgatgaca cctttggtgg tttccatctc aagcagagtc ttcgccatag 123300 aaaactgaca tacagatacg gacttctcac gaagcttaga atatttgtaa tcattacgtt 123360 tatcaaggcc aaagatgcct tcacgcaaat catcacgaga caaaacatac caacctggat 123420 tagatgctac gtattcgtta gcccaggttg ttttaccaga gcctggagct ccttgtgtca 123480 aaaccaattt tttcattata catccttaag agtgtcaata aaatcatgaa gagccttaga 123540 cttttcaccc caattagcac gatatttttc tttaattgct cgcaatggct tattcattga 123600 cagtatatca tttttgtcat aattttcagc tgcgcgtcca aacacgatgc acgccaattc 123660 attttcagca attaaccctt taagtgtttc atactgttct tggttcacta catcaccatt 123720 ttagaaagat tgcgatgcgc caatgagcga cgctttccat gtttcttcaa aaaattgtta 123780 acttcatctt gctctacacc gccactttct acaaattgga gtgccttacc gaattcaatt 123840 gaggcatctt ccaattcaga aattgcttcc ttcagtgcct ctttacgctg aacaaactcc 123900 aaaaaatcgg gatacataaa ttctgtcatg aatagtttaa accacacgtc aaacgaaatt 123960 cgtgtttggt cattaagctc aaacactctt tcttttaaag ctccaggcac actaacacgg 124020 actgtataaa catatccatt agaaatattt tctggtacag caatagcttt cttaacaaga 124080 ggagttaact gacacgaacc aacagctagc atattcctaa gttgtgtctt tttaatcgat 124140 aaaagatgtg atgcgtcttt tacgaagtaa gaatgaaggt gtgacggttc cataatattt 124200 tcctcttatt tagtttactt aacgcaacga ggttctttaa ggtcagaacg ataataacat 124260 atcattccgt tagcatcttt agtataacgt aaaatgtcat tcatccagat gcgatactct 124320 tgcgactctt caaatggcat acctacccag gctttaccgt caattacttt tacttcccaa 124380 tgtccttccc acttttgaat tgggtctggc caatcaggat gcaaaaccgg gacatccggt 124440 gcactagaag aacatccaac aagtaggctg ataataccca tggctaatag acttcgtttc 124500 atctggtagc ctcctggata tcttctgcaa acttattgaa gcttgcgtta atctgttttt 124560 caaccaatcc aggtttagct gcgactacat ttccacgctt agaatcttta ttcattttag 124620 cgttggaagt atcacgcgca gctcgatttt cctgatagcc tttataggtt gtctgcagat 124680 tttttataga aacaccaatg ttttctattt cttttgcttg tcgatcagat tcatcttgga 124740 cgactttgag gtcagcttta agattttcta cccgccacga aagatatttc aatccgcctg 124800 cagataatgc taacactcca atcatcaacc aagttgtgtt tattttgagc atagtttgag 124860 gataacctct acaatatcat cacgggataa acccgaaata aggatatgac gatcagagct 124920 ttctgaagga gaacacttga agcaagcttc tacgtattct gccatttcag aataattcaa 124980 ctcgcgatgc ataataccaa gacgatgctt gccataaatc gggtcaacga ttacataaca 125040 tttgcatccg ttagcatgaa cgtttggctg ggtgatgttc ttgaacacct ctgcaccata 125100 cttcgcgaga tgattatcta ggaaatcaat catttcatct acggcttcag gaagggcttc 125160 ggcacgctgc tcgttcacac gattagtgta ctctttttgc ttcttacgag cagcttcctt 125220 gcgcgccatg tgcgtccgta ggtcagtgac aaatcccact ttcttggtac cattccacac 125280 aaaaatccca tcagaatgag taccatattt gttaacaacc atatctaaag taattgcttg 125340 catatccatt tcaatatcct catcagttga tataagtcta tagtatcaca ctctgatgag 125400 gatgtaaaca actattcttc agaaatttca atttcttttt cgtactcttt tggaacatat 125460 cctgcccagt acttcaagaa cactctttcg aggtctttaa gcagtttatc tacatctaca 125520 gttccttcgt acatgttcat gataacacca aaaagatgac gctgattaac cgttgctttc 125580 tgagcagcaa tagcgtagtc tttacgagca cggcctctgt actcatcata aaatgactgg 125640 catagttcaa gtgactttcc gaggtaatct agataagctt gctcaaacgc agaaattttc 125700 ttaattgcgt attcatctcc agcaaaaaga gaacgcaagt catcagagtt tgctgataca 125760 acagacgcaa acaatctttc atttgacgtt attgagtctt tagtgtgatg aagagccgag 125820 taccattcgg tcttaacctt aaatctctgc ccagtgttta gaactgcaat gtatccttct 125880 acgccttcaa gcgcacgaac tccttcaacc caggtagtag ggtcagaaat tccgtaagca 125940 ttaattaaat aaggacgaat tttagcatta gcgtacaaat catcatactt aacatactcg 126000 ccggttgtgt tatcacggac gtttaacaca aacagctgtg gatcctgata tgctaaaaca 126060 acacgattat taggtgaaac aaattccatg tttaccgtat aaccatctag cgctagctca 126120 agaataacct gatgaagcga agaatattct tcactgttaa gcaaagctga agcttgtctt 126180 gcctggtcac tatagagaga tgtttttgac ttaaggtata gatacccatc atcgacataa 126240 gatgacacta gagagccatc agccttatcc ataatgtatt ctacatcgct aatatcaatt 126300 cccatcgtca ttgggttttc attcaagtta aagaattttt ccattggacg agaagcaatt 126360 cgaattggag tatcaccatc catttcaaac atgatgcctc ggcactcaag agcatctggt 126420 tttaaccact cactgtagct tgcgtagtga tatgaaaaca ctctgaactt gccatccata 126480 ggaccagtaa aatctttata aaagaatttt gcaacttctg agctttcaca cagattcatt 126540 aaatttttat atagctctaa catttcttta ccttatgttt gcaattatcg tagtgccatc 126600 tgatagcaat ggcctttgaa gttattatac cacaatgcgg gcatggactg tacaaaggct 126660 ttttctttcc tttttgactt tctgaccgct tgagtttagt ttcttcagat tgggttttac 126720 cggtcaaaga ttttgatatc ttttcacgcg tttctttggc acgagtcttt ccttgggtgg 126780 ggcttactct gcctttcagt gctttagata aattctttct atgttcttcc gttcgtttct 126840 ttccggagaa taagttagat gtataattag aatgctttat tctagagctt tcataaaatc 126900 tggaatgaac tttaaaattc tttccagaag aattacacat catccaaaga gcataattca 126960 ttttagaatt attatgtatc tttgataata gcaaatgggc aatgaaatgt tcacgtccag 127020 tcaataaaac taaattagaa acatcgtcat ttcctcctaa tgattttgga atgatatgat 127080 gagcttcagt ataatagttt aattttcctt tatcattgcc tcgtaattta ccctttgcta 127140 ttaggttatc atatacttta acatagttca tttagctttg ttagtatgtt gtgtgttcca 127200 tggaggattg aacttcttaa tcagaagagg ttcttccaag tccatagtgg atattgacat 127260 ctcgccaagt tcattattaa tcaaaagatt aaaacactga cgagcataga actctacttt 127320 tttgccagcc attagtgctt caaaaatctt ggcagattta gccgaatcag aggtttggtc 127380 tttccgatta atagcagttc tataataatt tatacgttta cgaagatttt tagtcttacc 127440 aatgtaaact agttcatcat caactgcgat ggcataaact acattcaact tgtttgctat 127500 caaaattggt ttgatggtaa aatctggttc taactcaagt tgaacatatt ttataaaaga 127560 aaactcgtta gcaatatcat tcataataaa gaggggccga agcccctttc cttataagta 127620 ctttttaaat ccaattagaa catcatcagt gacatcattg tcaatctgag ctaccagata 127680 agaacttatc tcaacttcct gaggagcaga ttggactgca tcagagttaa gatattcgcg 127740 aatccaagga ataggatgac gagttggtgc atcagtgatt gggcacggca gcccacagct 127800 acgcatgcga gatacagtca gatagtcaat gaagtcatga agaattttaa cgttcagtcc 127860 cggaagacca ccgttgcgga aaagatggat agcccaatct ttttcttggc ggttaacttc 127920 catgaagatt ttaattgctt cttgttcaca ctctttagca atctcaaccc attcttcgcc 127980 atcagtgcca gtttgaagtt gacgcagaat gtactgtgtg cccttcaaat gaagttgttc 128040 atcacgagca atgaacttca tgattttagc attaccttcc atgatttcca tatttttatg 128100 gaagttgaag gtacatgcaa aactaacata gaaacgaata gcttctaatg cgttaataac 128160 atgtaagcaa agataaagag atttcattaa atcacgttta gcttctttaa tttcgatatt 128220 atcttgatta aagcagcgat ttttggcatt ttcccatgcg cgagtcttcg ctataacatc 128280 atcatagtaa acaccgattg actcagcgcg tttcatgatt gcttcgtcaa gaacgatttc 128340 atcaaagatt ttagctgggt ctacatatag gttacgcatg atatgcgtgt acgaacggct 128400 gtgaatagtt tcactgaacg tccaagtctg gttccaagta tctaggcttg ggtcagaaat 128460 aagtgcagat aaaactgctg ctggagctcg tccttgaatt gaatcaagaa gagattggta 128520 cttcaagtta tcagtgaaga tattacgctg atgttctggg agtttttcaa actgaccacg 128580 gtccatcata acgttaactt cttcaggacg ccaaaagaaa ctcaattgct tctcaatgag 128640 ttcctcgaat actttatgac gctgaatatc atagcgtgca attcctagac cagaaccaaa 128700 gaacatcggt tcagtcatga tatctacttg cttggtatta aaaactgtac tcattctatt 128760 tcctattctg tggtgttaac catccgtggt ctaattataa ttccctttta ttaaagctta 128820 caggccgcgc agtcagcaga gtcttgaatc atatcatcgt taccggaacc atcacgggtg 128880 ttatgatagt aaagagtctt accgccaaag taccagaaat aaagcaagtc gtccatcatt 128940 accgacattt caacttttcc tttagggaaa ttcgccgggt cgtaataagt attagcagag 129000 atgctttggt ctacaaattt ctgcataatc agaacctggt tcagataagg cttattaccc 129060 tgtttcgcga gctgccaggc ataatcataa agggaagcat tgtgttcaac atttggaacg 129120 acttggttga agcttccttc ttttgattct ttaactgaca ctggtccacg tggtggttca 129180 ataccgttgg tagagtttga tacctggcta gacgattcgc atggcataag cgcagatagc 129240 gttgaatttc ggataccgta tcgcttgagg tcttctcgca ggagttccca gtcacagaca 129300 tagtttggag ctgcgagttg gtcaattctt tcgttgtacc agtcaatagg cagttcacca 129360 cgtccgtatc gtgtttcttt gtaaagcgtg catggacctt tttcgctagc aagtttaaca 129420 gaggctttga tgagtgcata ttgaatacgt tccatcattt cgtgagtaat atcattagca 129480 tctgcgtatg aagcaaagtt gcttgctaac caagctgcat agttagtaat gccaacacct 129540 agtgctcgac ggtctttagc ttttaacgct ttgtctacag gatagtcttg gtaatccaaa 129600 aggttatcca aagcccttac cattacttct gcgatttcgt tgacttcttc ttggtcttgc 129660 cagttgaagt tgtcgagtac gaatgctgcg agtgtgcata gcgcgatttc gccatcttct 129720 tggccaacat ccgaagttgg taacgcaatt tcgaggcaga ggtttgattg cttaaccgta 129780 gccacatcac gaataaaagg accatattca ccaacgttat ctaccatgta cgggtaaatt 129840 cgagcagtac cagcacgttc agtaaggaac aactcaaaca gttcacgagc tttaatacgt 129900 ttctttctta tatctgggtt cttttccagt tcttcatata atgtacggaa cgcttgagca 129960 tcacggaagt attctgtgta cagcgtgcca agacatacat cgggactgaa caatgtgatg 130020 taatcattct taatcaagcg ttcaatcatt aggttattaa tctgaacacc ataatccaaa 130080 tgacgaatac ggttttcatc tacacctttg ttgttcttaa gtacgaggag gttttcaact 130140 tccaagtgcc agattggata gtacagtgtc gccgcgccac cacggactcc accttgagag 130200 caggatttaa ctgctgtttg gaagtgtttc cagaaaggaa taactccagt atgtttgact 130260 tcaccgaatc caatttttga accttctgca cgaatcatac ctgcattaat accaatacct 130320 gcacgcttac tgatgtattt cgtaattgat gcagcagctt cattaattga attaagactg 130380 tcaccgcctt caataaccac acatgaacta aactggcgtg tcggagtacg aacaccagac 130440 ataattggag ttggcaatga aatcttttta gtagaaactg catcatagaa acgaataacg 130500 tttgctaaac ggttttcgcc atcatcttgg tgcaagcaca tgccgatcaa cataaaggca 130560 aactgtggtg tttcatacaa ttcaccagtg tgacggtctt ttacgagata cttctcgata 130620 agctgcattg ttcctgcgta agtcatagtg aaatcacgct catgcttaat ataagaatca 130680 agcaaagcaa tttcttctgc tgaccatttg ctcaggattt ctttatcata cttatttgcg 130740 ttaacacatc gggaaatgtg gtcaataaat gcaggtggtt caaactggcc ataaacacgc 130800 ttacggattt caaacatagc tgcattagaa gccacatatt ggtaatccgg ttcatcaata 130860 gaaatgctat tcgccgctac cttaacgata gtcttttgga tatctgcagt gctcatccca 130920 tcacgtagat gggatttaat aatttcatat aactcgtatg ggtctacttt tgttccttcg 130980 catgcccatt cgaggacttt aatgattttc tgcatgtcaa attcttgact aacacctgag 131040 ctcttaatta cttgcataag tcctctaatt caaatgtatc tttaaaaagt ttattcacta 131100 caagagctat tatatcacca tggcaaggaa gcggtttgca ggtgcatcct aatctcattc 131160 ctcttaaagt ttctaagtgc tctcgcttta tttctccgtt ccgaatctta gcaataaaat 131220 cgtccttaaa cgcagcaata gcatcaggac gattatcgca atctttaccg acgtaatttc 131280 cccacattgt tccgcgttgg atatttacat cgaagtcgga atggtattta ttaaccaccc 131340 gacatatctt catgttatat caacttcaaa ccaacagatt aattgtgttt tgcctataga 131400 ccattcatat gatttaacaa tagacagaac cctttgttcg gtcccgtcaa aaactatctt 131460 gtcattaact tcaggcaaat cactagagaa tgcatcacac atctcgccta atattgtttt 131520 agactggtgt cctttacgaa caaatcgaat attcatatcg ccatctttcc tttaattgtt 131580 gggtgagatt catatccttt aagaacaaag tcagatggtt tcatcattcc tgtaacccaa 131640 gctaattgtt cttctgttgc taattcatga aattctttat cttttactgg aggccaataa 131700 ttaatttcaa gttcacacag ctcttttggc tctcgacgca agatttcttt acactgttca 131760 atatggttca gataaatgtg agtgttacca ccagtgaata ccaaatgccc aggtttaaga 131820 ttggtcattt tagcaatgat atgaaccaat gctgcatatg acgcaatatt gaaggggagg 131880 ccaaggaata catctacaga acgctgatac cactggaggt ccaaatatcc tttacgaacg 131940 ttgaactgat aaagcagatg gcacggcggt aatgccattt tatccaaatc gaccgggttc 132000 caagcagtca caatctggcg acggtcagat ggcagttgtt taatacgatc aatgactagt 132060 tttagttggt caacgcccat gaaatcacgc cattgctttc cgtacacggg tcctagctca 132120 ccaccggaat accccatgtc ttttgcctgg ttttcgtagt tgtcgtccca aacagtttta 132180 ccttccagta atgaaccatg ctgaataaga cgcaattcat ggacattagt agacccttgc 132240 aagaaccaaa tcagctctgc aatacacgct ttccatgcaa gacgcttggt agttacagca 132300 ggaaaccctt tttgtaaatc aaaacgtaac tgagtaccaa acttcgcaat agtgccggta 132360 ccagttcggt catccgtctc ataaccgttt tcaaaaatgt ctttaattaa ttcttggtat 132420 tcacgcatta aatttttcct gaagaggtgt aaagaaaagc tgattaccac gcttttcaaa 132480 tcgcccaata atagacacta catcatcttt gaccatcaca ttgccatgtg acattccgat 132540 gaacatcttc ttataatcac gttcaatttc aataggtata tttccatttc ggttatatac 132600 tgtagttgaa ccgttataag tgctaagacc attataacta aaaactagaa gatgaatacc 132660 atgcttaaat ggaaatcctt tccacttctt ttggactttg tcttctgata gctgagtgat 132720 atcatagttt gcgctcatag accacctctg aaatgttagt cacttcatca atatgatacc 132780 aatgattttc tttagtaatg aatcctgatt ctggacaagt aggagctgct acaaattcag 132840 caggtagagt gacatcagaa ttcactctat gactttttct gatggttgtt tggataaccc 132900 tatccgcata tggatatgcc ttctggatga ttccggcacc acctatgata gaataattaa 132960 ggtctctatt aaaagtgata gtactgttgt aagaagtatg agcggccata atgtcaccac 133020 ccaagaaacc gataaattct aattcactta cataagcatc tgcaaagaag ccatttttag 133080 cagttgccaa cgcacgactc atgtcttgga caacgattgt cttacgacca ggaagaggtt 133140 taggaaaact cataaaagtc tttgctccgc aaatcaagat agtatctcga gtacgattag 133200 caaagttttt catatcctgg gaaatatgtt tccaaggaag accatcgcct aaaccaaaag 133260 cattttcgtt tttgccgtct acggtttttg taggagcaaa tgcataaact atttgaatca 133320 tttaaacctc agcaaaattc aactcgttca acactgccgt cttcccactt ctgttgaagc 133380 tcttgaaggc gtttaattgc actgtcgaca ttggacattg cgcagatagt tacccattca 133440 cggccgtccc accaaatcaa atcatcgtaa tcatctactg cgaaattttc cattaacctt 133500 gcctcattcc acacttaaaa caccggccac ctaattgcca taggctacca ccacagtact 133560 tacaatccca gtcagttaaa atccacatga cttgtaccca ctagctttaa tcatgctctg 133620 aagagtttta aacccttctt ttatggcttc tgaaatttcc tcaaatactt cctttttcag 133680 aatgtacaac gaacccgctt gattgccaga aagagctgaa ataatcacct ggtcattaat 133740 tgaaaactcg ccatatgctg aatcaatttt acctgaaact tgattgtctc gggaatgagg 133800 gtcaaatacg agctcaatat gagttactcc aggaatttca tcaaactggc agcgaatatt 133860 aacgcgagga tatcccgtta cactaaattt agacatataa aaataatcct aatataatgc 133920 cgctaataaa agcggcagta acagaaatta gcaaaactac taattcagcc tcaatcattt 133980 cttggcctta gcaagtttaa atgctttttt gaattcttca acatcttcaa caggaatcca 134040 gaagcctgag ccatacccat cttcatagca tgggcagtta tcacagtaat cattccaata 134100 gacagtttca ccacccatag tgaatggagc ttccatttgg cacagtactt cttcaacacg 134160 ctctaattct tctgggtttt tatcgcaaat gcagaaattc catttaccac gatattcaga 134220 accaagtttg atgctttgac gttgaagttt catttttatt ctccagtaga ttatggagct 134280 atactatcac aagcatagct ccttgtaaac tactttttga aaactttttt gatcaagtca 134340 atcatttctt ctgcattttc taaggtaacg atcaagtcca agcgagtagg accaggtttg 134400 attgcactac caatttcata tactggttcg aagtatttga attcataatc agcgatttca 134460 aagtatgcgt ctccaaatcc ttcggcatca gcagttgttc catctttaaa ttttacttct 134520 gtgatgaaaa tattatcttc atcgagcatt ttagtaggaa agaacgaacc accatgctct 134580 tcaatcatca agcgcatccg gcgatttccg ctagatgaaa ggtcccactc ggcagcaaga 134640 cttgggataa tgcggtattc tgtgttcagt ttcataattt acccgctaaa agtcgttaat 134700 gtatcttcac ggcattcatc atccatgcca ggaaaatatt cttgttcaag ccataaccat 134760 agagtaggag tatcaccttc tactgtgatt tcgtttcctc cccatggggc agacttgtta 134820 ctaacttcaa tcaaaccgta tttttcaatg gtttcaatga agtgttcata atcatatatt 134880 tctacagtaa cctgtgccat tatcattcct caaagtggga ccgaagtccc caaaggtaat 134940 tactctttcc agtcttccat catttggtca atatcttccc aatcgtttgc ttctaaccaa 135000 gcacgaactg cttctttaga accacggagg tcaatatttg gccaaccacc accagggcct 135060 tctttaataa ctaaatcaaa atcaatacca tggtcagtgt cataaaaacg tgaaccatct 135120 tcaaaaatca aatcagtaca aaatcctgat ttattgatgt aaggttctgc cacgatatca 135180 atgtttaatt tacccatgat gttttcctct actcgttttg tttcgatgta gatatagtat 135240 cactcatcaa ctggcttgta aacaactttg tgaaaatatt tttggaggga taaagaaaaa 135300 gggacccgaa ggtcccttta tattagaggt cgttcaaaat atcattcaga tcgtcatcgc 135360 caacactgtc accagcatcg cccatgatat cgtctgcgga acgagaagag gtcggtttgg 135420 attcaaaatc agacaggtct ttgtcaaagg aatccaggtc atcaccaatt ttatcggctt 135480 gagctgctgc ttttgccgcg gcaccaccaa gagctgctgt acccataatc tgtttaaatt 135540 tagcttcgtt aacttcaaac gatttaaact gagatggagc aacaatttcg ctgaggtcag 135600 ccatattttc ggtcaggaat ttctgagttt cttcatcatt gatgtttgca atctcggact 135660 gaccaaggaa tttacattca tcatagttct ggaaaccacc gactttctta actttcatga 135720 cgaagtttgc accttcatac acgcaagtta catcaaccgg agtttcaccc atatcaacat 135780 cgacttcaac catcgcgttg attttgtcca taattttctg accgaaacgg aatttaaata 135840 ctttaccttc gttttctggg ttagccgggt ctttaataac caggatgtta gaccagaaag 135900 aggttttacg tttcagaagc ttatattcag ccgggttgct gttataagaa tcgtttttgc 135960 tcagatgagc acaaaccggg caagaatcaa aatcaccgtg ggtagaagta caattttcga 136020 tgtaccattt accagcgtgt ttgaaaccgt gattgatcag ttttacaaac ggtagagagt 136080 tttcatcttt accaggcagg aagcgaatta ctgcttgacc attaccagca ttatcggtct 136140 tcagtttcca ttcgttttta tcttcattag agaaagaaga accacctttc agaccagcca 136200 gttgttgttg aagttgagca ggatttttac gcttaaacat atgattacct ttttaacagt 136260 tgttgttgca acatgggtcc ttgcaactgg acgatagatt aattatatac taatttcttt 136320 acaagatttg attatgctaa taaagagttt cttagcttca gcaccgtcaa cgtttaaaag 136380 ttttttataa gcttttaatt tagtggagta attactccaa actaagttat ccgttgcagt 136440 atcatgtgta tttattatat ctaaaaacga gtcaagcatg atgaatgtct cgaaagatat 136500 aacgtttgac tgcagaagtt tgaacacata agatgttccg actttctcat tatattcaaa 136560 aatatcatga agcttatcta cattaacttt cttagcaaag tagtaaatat tctttacgtc 136620 ttcagagaat gtagttttga tttgcttcaa cttaccgatg tattcacgat aaaacacgag 136680 ggcatcagca tcactgatat cgccaatcca tgcatcttgg ttagctacga ggttactcat 136740 gaatatcagt gttaactctt ttaatgtata tttctcagcg agtttctcaa agaaatattt 136800 gtctctacgc ttttgataag ctttatcaga gacccgcata acccagttat acttaacaac 136860 gtcatatcga ccggcaaagt gttgtttgag cattaaatat aaaagataaa cgctcttacc 136920 gttaacgtat ctgttattat ttccaggcat gcggagacga atcataataa aaagtccaga 136980 ctattcgttt tgtgtgtttg actaaatgat ggacgaagca tattttcttc caatgcttct 137040 gacataattt tttctatgat tgctggagga atatatctat tgaagtttcc ctcaggaata 137100 gaattttctt ctaaccactg agttgttgct tcaagatacc ccattccaag ttctgttacc 137160 atagactcaa tagtaaatcc gttagcttgc ttatctaaca gctgattaat ggattcagag 137220 ggggaggtat ccccctcgtc tttaagcgaa aatagagtca taagcttcta ccacttcatc 137280 tttttcagtt tcaaaacgat cgcgtgtgcc tttatggaac agagcaagca gttgattaaa 137340 cagtttgcct tctacgccaa gttctttctt ggcgcggtct ttaatgtctt tgttaagttc 137400 aagatagctt tctgctttca acttattacc tgaggcttcc ttaatcatat ctcgcagagc 137460 ctgtccatgt accgcttcat caaatactac ttgctctttt tctttcttag ccattatatt 137520 caccttaaaa gttgttaatt tctttcatta atttagacag accggattta acaaagtagc 137580 tataaatttt accacgaccc ggtaattgat agttattata acaatctaaa atgttagcaa 137640 caatgtcttc gcggatgtaa tcaaaatcga ttaacacacg gttttctaag aaacgcttat 137700 actgttcttc agtaagcaaa tctttgatgt tttcgccagc atcaagacat tcttcaacaa 137760 acgtcatttt cgttgaagga gtacgctcac catcaacatg agtgtaccaa aaatctgaac 137820 gaactttaat agaagctacg ttatctttct tgtcgccttt aataatttta accatacaat 137880 ctaaagcagg agaacccgtt ttagatttca ccaatttctt ctgcattggt gaccattgct 137940 taacattagg atacttatgc aattgagtaa agtcaccatc agaagaaaca atcataacag 138000 gatgaccttc gagactgaac tttttggtca gtacagcaat actatcatca gcttctgctt 138060 tatcaatatc aatgacgtaa taaggcatat actgcttaaa ttcatcaatt acagtacgaa 138120 gaccttcaaa gtaaccttcc cagtcccaat tggattcttc acgggcttta gcacggttct 138180 ttttataata atatgctaca tcccggcgcc agtatccgtt gattgcatta tcaacacaaa 138240 tgacaatttt tgtgtatcca tctttcttcc acttaaaagc attaaatttt aaagtagaaa 138300 gaataagatg acgaaccata ggagtggtta gtttatcgcc ttctttatac gtatgaagaa 138360 ttgtcgccat tgcgatttgc gacaagtcaa tcagaatgac accttctttt acttggtctt 138420 cttcggcgaa taagcaattt aaatcagaca tttgaacctc gttcaattag ttagtacagc 138480 cattataaat acttctataa tgaagcataa cccccatagg agactctatg agcgatttac 138540 tgaaacaaca tttccgtgca acgaacggct tggacgcagg cggaaataaa gttataaatg 138600 tggcactagc tgaccgcaac gttaaaaccg acggcgtctc cgtcgagtac gttattcaag 138660 aaaacactat ccaaaaatat gacccgacac gtgggtatct cactgatttt gctgtgactt 138720 atggacgtcg tatctggatt gcaaataaag atattccaaa gcctgctgga gattttaacc 138780 aggcgaattg gacttcttta cgtgttgacc cgaactggat ttataccgtc cgtaaaggag 138840 agtttgaaat tcaatctggt cagttcatca acgttgactc taacgctgca ggtaatgcta 138900 cattactgct tccgttagca ccagatgaag gcgataccat cgtagttcgt gatattggcg 138960 ggcgtcctgg ctataacgga atcttaatta aagcacaaga tactggtgcg tctatcgtat 139020 ttggtgaatc gcgtctgcgt gaggtaagac ttacacgtcc gtattcacaa attatgctta 139080 cgtttagtaa tggtgcatgg cgtgcaagtt taaccgattt tggcgatact gctaaaatgg 139140 tagttccgaa cgggattgtt ccaacccagg tacagtcagg tgataacgta gttcgtcgtt 139200 atacttccaa ctcagagatt tttattactc tgccgttgtt cgctaattca aacgatatca 139260 tcaattttac tgaccttgac ggtacatcgc caattaacca tatgactgtg cgtacgtttg 139320 acccaactat ctcgattggg actcctggac aaacagaggt tcaagtacgt acttcaggta 139380 atggattttt ggtatatgac tcgattgaca aaatctggcg tatttttgaa aatgatttac 139440 gcacccgagt aagaataatt acttctgacg ttactttaat gcctaatgag catatttctg 139500 tatttggcgc agataacaat accgttaaaa caattaacgt tactttgcct acagacgtag 139560 ctgttgggga tactgtcaca atcgcaatga attatatgcg taaaggacag actgtagtaa 139620 ttaaagcatc tggtggtgat actatcgcta gcaatttgaa tttactgcaa tttccaaaac 139680 gttcagagta tccacctgat gcagcatggg tgcaatcaag ctcgattacc tttaacggaa 139740 ctacatcgta tgttcctgtt cttgggcttg catatattga agataaagca tccggaaaaa 139800 gctattggat tgtaactgaa tctgacccta ccgtagaacg agttgatgct aaagacaaca 139860 caactagagc tcgattaggt gttattgctc ttgctacaca ggctcaagct aatgcggagt 139920 caaacccaga aaaagaatta gcaattacgc cagagacatt aaatggacgt cgttctactg 139980 aaacccaaac tggtatagca agaattgcaa cttccagcga agttaatcag tcaacaactg 140040 cttcttactt ggataatgta atcgttactc ctaaaaagct taacgaaaga gctgctactg 140100 aaactcgtag aggtttagct gaaattgcgt ctaatgctaa aatggatgca ggaacagacg 140160 attttacaat tgttactcct aagaagttgc tttatcgtac tacatcagat tcacgattag 140220 gtgttgttca gttagtaaaa actggtggtg ctcctaacac aactgctgat cgttcttctg 140280 ctggcaccgg tatattcgat cattctgatt acaaaaatgc agttactcca aaaactcttc 140340 gtgagtataa agctactgta aaccaatcag gaatagtctg gttagcaact gatagcgaag 140400 ttagaaacgg aactccggct tcttcaaata ttcctacggt tgttacacca gaatctttgc 140460 ataaaaaagt tgctactgat ggagcaattg gattaatcca aatagctacg cagacggaag 140520 ttaatgctgg cggcgtgact aataaagcag ttacacctaa aacattaaat gaccgtacag 140580 caactaacga tcgtactggt attgctcgct tcgcgacacc tggtgcccag ggtgaatttg 140640 aagctggtac ttcaagtaca gtaatggtaa accctaaatt actgttcgat aaatttgcta 140700 atactggtcg tatccaagtt aatactagtt ctggcttaac tattactggg aacctctggg 140760 accattatac catcaacata caggaagcaa gtacttctca aagaggtaca accactcttg 140820 ctactgctgc tgaggttaga accggcaccg acgccaagaa aatagttact gctgccacgc 140880 tacatgctaa aacagcaact gaaggagcta tcggtcttgc tcagtatgct acacaggcac 140940 aggttgatgc aggcacatta agtgatagaa ttgttcctcc tgcttacttg aaacagacta 141000 ttcaggtaac agagtcatgg caagctacag acagcgttag agggaccgtg aggctatcta 141060 caggcgatgg aacgtggaaa ggtaatgata ccaatggctc aactcttccg gataacgggt 141120 atgcctctaa gggcgtcgca gtgtctccgt atgaattgaa cctcacgttg aaacattact 141180 tacctcgtct tggtaaagcc tatgacacag gaatgttagg tggtcaaacc ccagacaaat 141240 atgctcgccg tgatatagcg cagaccattt ctggagcttg gacgtttagt caggacactt 141300 catttagcaa taatatttct gttcagaata ttatatatgc taatggtggt gaagttaaaa 141360 tttctccaac agctgatact ggaaatgtgc atgttcgttt tcaaaataga gatggaagcg 141420 agcgtggtat aatttatgct gagccacaaa ctgcttcagc tggaaactta aaagttcgcg 141480 taaaaaacgg aacaggaact actgctgcaa gccagaccta cacatttggc ggtaacggta 141540 ctttagatgt tcctaatgaa gtatcaacta aaaccctgag gtcttctgga aatgcaatag 141600 ttggcggaac tgttatggtt aaggacgttc agatgcttgc tgtcgaggga ttgaattcaa 141660 tattcggtgc ccaatcgcag tccgcattta ttcgttcccg tgacgctgat acacaaattt 141720 ttgcgcagga ttcaactgga tcgtatccaa ttttaactac caaaaactat gcaagattag 141780 ctgatggtcg ttatgttaag aaagctggtg ataccatgac cggcaatctt aacttaagcg 141840 gttctgctat cgtcattaca ggttctgaat catggtatgt tccaacaaat gaaactgtaa 141900 tgagacaagg ttcttggact gctgaaatta aagacgctac taaactaaaa ggtcttcgcg 141960 gttatatggt tccgatcaga acaccgattg accctgctaa tccaagcaca ttagtagtga 142020 ccggatatga agaaaaaact gctgctggcg gtgttttaac tcaggttggt gtaactacaa 142080 acaatactta tcagctttgg acgccttatc ctccgacaac tgaaactgct gataagcgtt 142140 tcgcgcatac tgtgtggatg aggatttata atccaaacct taataagttt gatgattgga 142200 tgcgagtatt tacatctgct actcctccaa ctgcagctga tatcggagct ccaagctcag 142260 tgtcaactca ggttaaaacc cttgaagttt tggaatggat taagcttggt ccagttaaaa 142320 tctggccaga ccgtccaaac caaactctca aatttgaatg ggtaggtgat taatggctga 142380 tccaatttta atggcagcct ttggtgagga tttcgtggaa acacgaatcc tctctgaggc 142440 aaactctgtg aagtattggc taaaagctta tgctacacat tctaatgctg ttccgaacaa 142500 gccagaattg aatattaatg gcgcctttga tatgacctcc tccttacgga gggggattaa 142560 tgtcgttcag gttaacggca atagttttat taactttaaa acttttgatg ttaccactga 142620 tgataacaac gctaataaca aagcgtttgt agaatatgca aatggattaa cttcgggatt 142680 gtatattata atgacgcatg aacgatttca atccagcccg ttaatagaca gatggtttaa 142740 aaacaagtgg tctgcttctt ggccaggttc tgacttttcc aaatcatttc caaactctgc 142800 ctatgttgga gtgctcggag cagcaaaagg acgtatatta attgagtcat tttacggaaa 142860 tgatggcgta gtcaaagaag attccagggc taaagtagat actgtatatg ataatgtggg 142920 cgatgtagga tatacaggct gcccttatcg ttccattgaa gataccaatg aatactcgga 142980 ttctactgga tatgaatata aacgttatcc agcacaaaat gaatctataa gcaaaatagc 143040 tgattatgga ttatctcctg gagattctgt atttttagta tgtgatatgt atgcatctaa 143100 aagccttctt gatgcgggtt ctactactag agctagcttg cggtggttca agggtacatc 143160 tttattatct tcaaacgtat cattagaagt tccaaaaaat ggagctgaca ggtggctaag 143220 atttgaaaga tttactgctg ttcctacaga cgctgatgga tttactatcg tggtatcacg 143280 atatccaaaa acgtctgtag ttggtgactc taaaatcaaa aaccttgtat ttgttcaaac 143340 ctctcacagc gaaaaactta acagcgttgt tcaagaattt ggtgtgaatg gtataagaat 143400 gaataaaggc gttgaaggag gaaccactat gattatggaa cttccaaatt caaaagtcga 143460 tccgagcggt gttattccag ttcaatcgtt cagagaaaca tcagactaag gaagccttcg 143520 ggcttccttt tttcgtataa atagaaaata tataagagga taaactatgg ccgatttaaa 143580 agcaggttca acagttggtg gaaatcctat ttggcacgca ggtacttttc ctcttgtgcc 143640 ggcaggaaac tccctaactt atagaggtaa aaaggtttat actgagatag ataaacctca 143700 agcaaatgat aacgacttcg tatctaaagc taacggtggc acaggttctc aaggtttcca 143760 acaagaagtc gaatttaaag ctggcgttaa gatttccgca acgttttctg gtggttcaaa 143820 cctgaacggg ttgtattctg gtaacggaga tggagatacc agagaaaaat ctaacatgga 143880 tttgcgttca tggtacggca tcggtatttg gaactcatgt acaagtgatg gggtccaggg 143940 gcgtacaatc tggttcagtg ctaggcgtgg tactatcgga acagttggtg atattgtttc 144000 aggttcccaa gttattgcta atgcttctac tccaacagcc gctcagcatt taactcgtaa 144060 agattatgtc gatgggcgaa taaatactgt tagcaacgta gctaacgcag cagtcaggaa 144120 agctggtgat accatgaccg gtgtacttag ggctaacgct ggcgtagtta tagtaaataa 144180 agcaacatcc ggtgaatatg ctcctagatt agatcaggtt atttcacgcg gggtaacaat 144240 agattttggc acatactaag aggtagccat ggccgatcaa aacttaaaac aaatacaatt 144300 taaaagaact agcacagaga ataaagcacc aggtgcagat atcgtagccc gtggcgaaat 144360 cgcgttgaat acacatgggc gtactcttgc catttacact aaagatgaag ccgataacgt 144420 tgttcagctt gcaggtaaag gggttccttt cttagatact gcaggtaatc ttaatgttga 144480 tggaactact acgttaaaag acaacgttac tatttctccg aataaagcga tcaattttga 144540 agcttcggat ttaagcggag cattagtacg tcatatcacc ggtaagtgtg ctaataatga 144600 tggctggtac attggagctg gtggtgcatc tgaccaagga tttcttgaaa tcggtacgta 144660 tgataacgga aatgaaccta tctattttgt tcaaagaacc ggtggaacga ctcaagctga 144720 agttcgtcgt ttagcattat tagatgggtt tggcgatacc tctatacctg gggaccttcg 144780 tttaactaat aaaacggtaa aaatttcaaa cggaagcact cttactttgg aaatgggtgt 144840 aggcgctaat gacgcgtaca ttaaaaacct gagaggaacc ggtgttcttc aattaactaa 144900 tgacagcaat ttaacgttca gaaattccca ggtttattac gctatgaatg gaagaggtcc 144960 tggtaaatcc ggtactcttc taactaatgt agaaaacaac cgtcaggcat ggcaatacgt 145020 aatttctgct gcaactgctg gaactccacg ttgggttaaa gtagctacaa ttaaacaccc 145080 aggagatgcg tcttcacagt tagatttaat gattaccggc ggcattgatt ctggacacgg 145140 aagacattat gttgatttta tcacgctatc tggtcgcaat ttaacatcct ggagcactag 145200 caatttagat aactgggttg aatggcgcag ggttggttct cctaatagag gaaacgctcc 145260 agaatattac gttgttaaaa atgatgctgc tacagattca gaggcttcat ttgattttta 145320 cgctaaagtt cctcgatacg gcaatgggct ttatgtcaca gtgctgaaca ctgctggata 145380 caatggccag gatagtggta aagtaattat ctacgaaaca ggccaagata ctggtgctac 145440 tacaccatct ggaagcattc ttgtttcaat gaaacagatt tttgatagta tcgcaaaacc 145500 agatttcagt gatactaccg gtactcttcc ggttaaccgc ggtggtacag gtgctactaa 145560 cgtaggagac gctcgaaata acctgggtct tagaactgcg gctgttcgtg atgtcggtga 145620 atctagcgga aatgtgatgg aagtcggcgc ttttggtgtt ggcggcggcg gaaaatcaat 145680 tgttgatatt acatccgatg tcgatttaat gaatcgcctt aaagctattg gtggtacaac 145740 atttagggct aacgttaaga cagtaaatgg gaaagctgag tataccgggt ctccttatta 145800 ttcgcatgga gcaggattct tttctagaac tggcgataca atggctgccc ttaatatcga 145860 ttattcatcc ggtaatgtca gagtatttgc tataaatgac cgcggattgg cagatggtaa 145920 agtaagctat aacatgcttt acggaacgtc aaataaacct aatgccgatg ataacgactt 145980 cgtatctaaa tcccgtggcg gtacttttgg agctgatgtt acagtcagtg gtgatattac 146040 tgctaatacc gtcagtggta gggtgttaaa actatccggt ggcggtgcag cgtatgttcc 146100 accttctcaa ggtgcataca tatcttggaa caaagaaaac gggtcaggtc gtactgattt 146160 tattaaccat cgttcaaata cttcaactgt tcctggcgga tttgattttt ggaactatga 146220 aggtaatact agcaacatgc gtcatctggc gcaaattaga aacactgggg atttagtatt 146280 attcccttct gacatatcta aagctgtgac attccagact gatggaaaca ttgttggtgg 146340 tactttattc ggtggaaact taaacaatta tttaagtaat ttaaccggaa ctgctaatag 146400 caaagtatcc aaatcgggtg acaccatgac cggtagatta aacgtctacc aatctgatac 146460 aaatgctgga gcccaggcta tatacattaa aggcgttcag catacaccgg tagttcttga 146520 aagaaatacc gatgcaaact tatcaatagc gttcagatta actggtgtta atccaattct 146580 tcaacgtaaa cttggtttag ctaaagatgg tactcttcgt tggggaaccg gtgataacca 146640 gacggataat gctttagtat ttgatcaaaa cagcattgga atggttagag ttaacatgac 146700 tggaggttat cttggacaag aagttgctga agacattggc ggaagaacgt tgtctattga 146760 tgatcttttc ttgaattcat ccgacgttgg tactcgtagg gtttattcat gcttagctca 146820 aggtcctgga gcaaatatta ctggaatgcc tcctgcgtta actaatctgc aaggtgattt 146880 cattcttatc gttgaaaaga tgagatcagc agctggtgta gatttccgta ataaacaaac 146940 atttatatct ggacgtaata ataaaaccta ctttagatat ggtgctggaa caggaactac 147000 ttccgcgccg gcggtcaatt ggacgccgtg ggaagaagta ataactacat caaacactaa 147060 cggtatttta ccaatttcgt ctggcggtac tggagctaat actgccgccg atgctcgtaa 147120 caattttaac ttaggtttag ggcaaactgc gacgtttggt ggattaattg ttaatggtgt 147180 tggaaataat gatccagtag tcacgtttaa gaatggtgct gtaattcgcg aggcccaagg 147240 tggtagtatt ggcgcattaa ttatgtcagc ttctactaca gcaccagcag ccgcgaaata 147300 tattgctttt cgtccttacg gcgatacatc taattctgag attagagtca aagcatatgg 147360 caataacgag acgatgcttg aatgggcgca aggccctgct gttcgttcaa acactgcagg 147420 tgcttttgta atctatgcaa aagcaggcca agcgattcat ttaagaccga atggcgatac 147480 tgcaagccaa tcaactgtta ttgaccaaac tggtaaaatg acagtcggcg gtgagttcga 147540 ggcccagaac tcgaaaatca caggcaactt gaacgtttct gaagataaca gaatgatcgt 147600 tcttggcaaa aactctgata ttggtttagt caagaaaaac ggtatgccag gaaaaatggc 147660 tatcggtaaa tctaactcat ttaccgttat ggtatctgca aataccaaca accaaattaa 147720 tcctgctgac acgtttagcg atatattcaa agttgatgct agcggaaacc aaactgttta 147780 cggaaatgcc caaattaaca ggcagcttac agtaacaagt aatactaact tgaactcaga 147840 cttgatagtt aaaggcaatt cccgcttcag cggtgtgatt aatgctgatg gaaacatcaa 147900 cgtcgcttct ggtaagtttg ttattgcagg tcaagctcct actgataact cgcacctaac 147960 caacaagaaa tatgttgatg ataaggttgc ttctgctatt agtaatgctg gcgatactta 148020 tcttccatta gcaggtggta ctgtaaccgg aagattaata attacaggtg atcagttaaa 148080 aactacatcg ctctggacta ccggagacgc tgctgttaac ggtgctttaa ctgttggcgg 148140 taatgttgtt agtaataccg gtattggcag ctttgttggt gctgtcgatg ttaaggcccc 148200 tgccgcagat aatggtacaa cacacctttg gttccgacat tccaatggtg gtgagcgcgg 148260 tgtgatatat atgccgcgtg acaataatac catgatggga ttaagagctg gcggaagcga 148320 atggcaactg gatggtccaa caggtcaaat gctaggaccc ggagcacgtt ggagaattca 148380 ttctgatggt aacctacagg gtgatgttta cggtggttat atcactaact atatcaacga 148440 taggtttaac caatgtgctc aatgggttcg tactggtgct caacaagact ttggtcaaat 148500 tggtcgccct gctcctggta aaactgttcc tggtggttgg gtagtagttg gtcttaacgc 148560 aaacagcaac gaagccaacc agaacatgca acttattggc ggacggttac aagtatggaa 148620 acctggtgtt gaatgggttg attctgctac ttgatagtgt tatggggctt cggccccttt 148680 aaacttaaag gtaatctaat gattattaaa caaatgaaag gcattaaatg gcaccacaat 148740 tttgagggtg gtgcttatta tcgggactgt aacgataatt gttggtacaa atttagaaat 148800 tctcttgata agaattctca tataattata gttaatgcta aaaccaacaa gataattaat 148860 tactataatg gcgaagatcc aaccatgatc gggttatttg ccgataaaga aatggttttg 148920 gatgtatatc aacttgatga ttttcctgtt gattcgtggg gcgaattcac acaaagagaa 148980 tttgaatttg tagacgaaca agttgtgatg accaaagatg tacaagttcc taaagaaaga 149040 actaaagatg atatcatgaa agatttaatg aagcttaagg ctgaattgga atcattgcaa 149100 taaatagctc tgtaaggaga gcaatatggc aagcaaacaa tcaataccat tttttgatat 149160 gtttcttggg ttgctcgagc tattattcaa agatggagcc acgggaagag ttctcttttc 149220 ccgtgttttt gttgtcgtac ttttagcatt gttggcattt gctggttata agtcagatag 149280 tcttattact gcttacgtcg atagtactta tgataagtat gataaactgg ttcaaaagga 149340 tagagattcc cgatttgata atacagcact cgaacaactc cagatagtac atatatcaag 149400 cggtgcagat ttttctgcgg tctttacgtt cagacctaaa aacttgaact acttcgtaga 149460 cttaattgct tatgagggga ctttacctag cacggtagat tctaaaaact tgggaggata 149520 tccaatcgac aaaacaactg ctgaatatag cacgcattta tcgggtagat atttttggac 149580 ggataaggaa tttgttttct taccaacaaa aagaaaaccg cctgaaatat cgtatatgtt 149640 tagctgtccg tatttcaatt tagacaatgt ttatgctggg actgttgaaa tgtactggta 149700 caattccaaa cctgcattat ctaacgaaag actaacatcg atatgtggtc aggcggttag 149760 agctcttgga agagctaagt gattacttat tactatgcat agccattgtt cgatagatag 149820 actcaaatcc ctcgttgtat tcttcaacga gaattctctt ctcttcgtca gttaactcag 149880 aaaccatttt acgaaagttg ctctgattta actgacgccc ctgctcgttc ttgattccga 149940 tttcattcaa gaacgcaata aattcatctc gcttctccat gatatgttca gcattgaact 150000 tagtcagaat agaagcaaca gtaacaattt cttggacaat ttcaaactta gtcattattt 150060 ttcctacaac ataatggatt atgtgattat gtgattatag tatcatcttg ataccgcgtt 150120 gtaaaccagt ttatgccaat tcccaacgag aattcaaatc ttccttggta gtgatatact 150180 cagcacctga ggacatccag agcccgtagc gaccatcttt tacactagcc gttaaatacc 150240 attcctttcc aattggacga accctacgat tcaaccagtg acatacgtca attgcctcct 150300 gaaaagacaa gtcaatcaga cgtccaagcg cgattttatt cattaatgct tcgagatatc 150360 tttgtgattc aacgacagat tctaagttat gactcatgct aaaacaacct ctccgcgatt 150420 acctaaaatg ctttcgatat actcaactcc acttataatg tcacctctat cctttgcttt 150480 aatagtaata attccatacg tgtaaaagtc ggctgacaaa ctgaatggct tagaagtgtc 150540 ctggttaaac gtagacatta ctgcttgctc taaatgtttt acttctaagt cattagccca 150600 agagttaaga actttaagcc taacttgtaa ggtgtattct actttaattg ctgaaagcaa 150660 ttcaacgcgt ttatgatatg ccttggcttc atcttctctg cgtaaagctt cagtattcat 150720 agataatctc caatgtcata agcatcaaca catttctgaa attgttcaat aacttcttca 150780 ggttcaacat tagcgataat agctacagta aaggtaccat tattccaatc gtgtaccatc 150840 cagtctccat atccagcatt ctggaggtct tccattagtt cagaatggat atctgctact 150900 aatccagaat ggtcccctaa tttcttgtgg agagcttcta ggtcatcaca aataatagtt 150960 aaagtagtac atttggaatt attcagaatg cgcattgtct ttacctttat gtttttgctt 151020 acgttttgat tctttggcag cacgcttttt atctttatgc gcgcctcctt tgttaaagtc 151080 attcttcgct actgggttgt acatgtgcaa ttacctcatt taagcagttg cgtgtaatat 151140 caaaacgctt agcaatacca cattcttgga tatgtgattt taaatctccg gcatgcacat 151200 atcccaattc caagataaac cgtttaattt gagccttttc tgaacgattt aagctattga 151260 agtaatctgc cttggcgctt attgttctca cgctttatct tccttacatt caagttcctt 151320 gatgtaataa tcaatatctt taatcatttc ttctgtcatt attttgtaca tttcagcaag 151380 aaatggttta gcaccaccat taaatggatg gctaaacggg cagatgtatt ctttatccat 151440 gagagttttc atgaatttgc tgtctgccat tttaaacccg gcttcattgg tatatgtacc 151500 ccaattattg tccatcattt ctaatgagcg ctgaagcgat ttacgttgaa tttttaaaag 151560 tgtaatgtta ttctttaatg tactaatcat tagtataaat cctctgagaa taattcattg 151620 gctggtcctg atttaggacg aactgtatta acttgacctg catgtgtagc gatgattaat 151680 gcttcttcac gcgtgaagta ctcaccccat tggtcaacaa atccttgatt gtctccatgg 151740 acatggtcag aaaccaattt gtcgcgaaac atatctaaaa cgttcgccat atcaacagaa 151800 tagtggcgag tgcctggaac tacaattgtt ccaccagttt tcaattcaaa acgatttgct 151860 gcacaaacga tacgacgttg aagtaatcgt ccatcccacc aatcagctac tttaaagcag 151920 atttctggaa tttcgctatt tacattacac atttgaccaa cttctcgtta aaggttttaa 151980 taacttcacg gccatggtct gcacctttct tacagtctgc aattgtccac gcttcgccat 152040 tttggtattt gtgaagagcc cgggtattaa tatctttcac aagattcata atcaaatcat 152100 taatttcttg ttcagtcatt taaagaatcc tttaattttc tgccacaaac ttttcttttc 152160 acgaataccg atttgacgaa taacaggttc accctgcatt ttctctaacc actccattga 152220 attaacagct tccgccattg gaacaaattt agcaagggcc ttttggtaat tatctacatc 152280 catgatatgt ttaccatctg cattgtagat agcatagcat tttgcgaatt tcttatcaat 152340 gtatccgata aagtgcccac ggaaccatac atcccaacaa tcagttggga tattagcatt 152400 caagttaact ttttctacac aacgctgaag ttcattcaat actttaaact tattcattac 152460 agttccttaa tagagcggat gatggtttca atgttttcag cagtacgggc gatatctaag 152520 taagtattgc ctgttgcagc tacacggcaa gacattccga ggtcagtgaa gtgtttctga 152580 tgctcttcag aaatcttgta accgaagata cggaaagtac ctttgttgtt aacttcaaga 152640 ctacgaatac cgaatgtacg tttttccaga actgcgatat agttactacg gtaaactgta 152700 agctctttca gaggcaagat atcttccatc tcgctaagaa tgctcatcat caagtctttg 152760 tgctcattca tatcttcagt cagaggacga gctttacgag tattgcgttt cttcagaagt 152820 tcaggcttgt tctcttctgc atagataact gccgctttag agatgatgtc ctgtgcttca 152880 ccagtgatga ttaaaccgtc accagatttc tcgatgagac ctttcttaat cagaacaccg 152940 atgtttgagt ttacagaact tgcgttcatg gtttcttcaa ggatttcacg cagttcagca 153000 gaggtgatga aatccttttt agctacctga accaggatag cagcagtttt ctcgttcagt 153060 gcatcttcag aagctttgat gatgtaagtt actttagaca ttgtgattct ccatgatgtt 153120 ttattcaatt tgtttggtat gagactataa tatcatctgc taaccagctt gtaaaccatt 153180 ttattctgct ctctgaaaaa ttttcttcaa agagcagtaa aaatgctata cgttaaagat 153240 caagaactta tcgccattct caagtttaag cacccagaaa tcatcatata cacaaagaac 153300 gacttgatac tcttcaccgt cttcatagtt actcgcttga attacctggc gcataggata 153360 ctcgcgatta acttcgaaca catcaagcac cacaatgtta cctttgacat agtggctcag 153420 tcgagtgcca tcggcttgag tggaaatata aagaatgttt ttgatatcag attttaatga 153480 tgtaatcatt ttgtttactc cgtgttgttt tgatatggct ataataccac agccatgtaa 153540 gcatgtaaac aactttgtga aaataatttg gggcattcta aggagggatt ttggagggat 153600 atagatttat atggaaggac ctggagatga cctccaggtt ccctagatta actgaggagc 153660 aataaaacta aaccaaatac agcaattaca gaacctataa ttaaataaaa ttctatcata 153720 gttcttccag gtctttcaga tactcggctt caggcgttgt cttttcccag tacttaacct 153780 cttgtgctag gcgttttgct tcctgagcaa gtttcttggc ttcatcatca gtgatgtgat 153840 agatgttcat tgaaacgagt ttttcagaat ggtctttgaa tagttcattc tgttcaattt 153900 ctttagtcaa ctgcttacga gttttacctt ggataacgat gttacctgca ataacctctt 153960 taataaattg agcttttgcc tgagcaagat taaacgcctg cttagtttca gcgattttat 154020 gctcgattcg tttggcggtg aatgtcttac ggacttctac aaaatgacga atcagctcac 154080 cggaagtttt gaacttgtca ttcagcttac cattctcatc gatgaccaca atgtattgac 154140 tcattttctc aatgagctta aagtccttca tgattttagc atgacgctgc tcagggtcat 154200 cgctcaaagc atagtcttta cggaatttca ccttaaagcc aaacccggtc ttagaacagt 154260 catcatcata tgtgatatat cctgcatctt ccaacgggtc aagtactttt tcaacgtaag 154320 aagctcgttc aaacttgtat ggaatttcac tgatatagat tgagttccgt gaagtttctt 154380 tatacacgcc gtgcagctca acagaaccgt cttctgtttg gacgattttt ccgttaaatt 154440 taggaaactg tacttcaggt tccatcattt caccgcgaag tgctgcttta gtgcattcca 154500 aaacagattc aaaactatgc ggaagaatag aagttgaata acctgttgca ataccgcgaa 154560 caccattcag aagaacagtt ggaattaccg gaagataata agcaggtgga acatgttctt 154620 tgtctttatg caccggagcg atttctgtgt ctttgtagat tttacggaag ttgtcagaaa 154680 tccggcagaa aatataacga cttgccgcag cagattgaac cagacgcgaa ccgaagttgc 154740 cttgcccatc taacagagga tagttgttat tccatgtgtt tgccatcaat gcaccagcat 154800 cttgagcaga ggtttcgcca tgatgataac ctaaatcagc tacaccgcca gcaacagacg 154860 caagtttgtg gaatttttct ttattaccac gagccaaatc aagggcacga gcaataacaa 154920 aacgctgtac aggtttaaac ccatcaatca agtttggaat agcacgattt tctacagtgt 154980 aaatcgcata ctcttttgct tcattatcaa tgatagattt caaatcgcga tgacgaagat 155040 ttgacgcctt agccaaatca tcaatagaac ctgcttgttt taatagagtg tcaaaaatat 155100 ccattgtacc taccagatta gtgagccgat ttgtactata acatcggaaa tgaaaagcac 155160 aatataaatc attccgtaaa tcattccata gtacataact aatagaaagg cggcagcaat 155220 agctgccaca attaggagtt tcttaatcat ttgtaaactc ctacaatttt acaaatgcgc 155280 tcaaacataa taaatgctgc ggtgaacgca atacttccga ttactttagt ggtaggcaca 155340 aggccatacc acatgaatgt tcctgagcaa atcattaggg ccatcagaaa cacatagccc 155400 atcacgaaga aggttctcat tagtatttct gcaaagtaaa gatgaagtta tcattcagaa 155460 tacgattcag ctcagagtag gtctgcgcgt cacttgaatg ctgacgagta aacgccagtg 155520 caagttgacc tttgccataa ccagtggtga gtggtttcat tttattagca ggaatccaga 155580 acacaccgta ggtcatgcaa ttcgagcgca gagtacgacc caactgagaa cgtccagaac 155640 ggatatgaga aagaacactt tcaaatcctg cctttgaacg ctgtttagct acaaagaaac 155700 gagcagatgc accaatataa cctgctttgc catcattgaa catcaaaaaa taaaatcctt 155760 cgcgctcagt aatttcacga gatggagcac ctgctgccca atcaccgtta cgaatagaac 155820 cgatcagttc tgcgccagcg ttatcgagat cagcaaaagt cataatatta cgcatgttaa 155880 tttcctcagt tgattaaagt ttattctccg attaggggcc gaagcccctt ctactaccaa 155940 aaatatacta ctgccgttac accaccaacc caaaacacaa gaagacctaa agcaagcaga 156000 cgatacacga tgtgtcgttt catttttgac cttcccatac ggtttctact aaggatttaa 156060 ggccatcagt ttgaataata tcaatcgcat taatggcaaa ataaattccg aatccgaaca 156120 cggcgacaat tccaagcgct accgcaacga taaaggacag aacaacagtt ctcattaagt 156180 taaagcgacg atcaaaacta ctacgaatca ttatattttc ctcagatgaa agcattaatc 156240 caaacgttaa ctaaatccca tgcgaaaaca ccaatgaaag taacgataag gcagaatact 156300 acaaaggtgt tcttcaaaat cgtaagtaac tttttcattt tgttctccag tttagctaac 156360 aggattatag tatcaccgaa gaacaagaaa gtaaaccgtt aaatgcacaa gttacgaatt 156420 ttttcttcta aggctttaac tttatctatg tgctcatcac gggcagcggc agctccattg 156480 ggatacaatc cgccgtaagt tgaatcgcca ttatcgcaag caatgatagt ataatgccaa 156540 ttcatagatt cgagaatcct atactctttc aaaagctcag ctttaataga agcatttccg 156600 cgtttagctc gaagtgattt tagctctaag taactcatgt tttactcccg ttcagtttgt 156660 aaggccatag tatcatggcc aatcccggaa gtaaacaact ttttaaaatt tgtgcatgat 156720 atacccgcca gctccaactc gtgaaggttt tactacttcc atgaggtgat cgataccgcc 156780 ggcaaacatt ggtgtgtacc gtatgacatt ctgggacact tcttctgcaa cgaatataat 156840 tatacagtct gcgactttat gtttaaacat gggccctaga tttattccac ttccatctgg 156900 gaatggaccg tctttaccag ttgtaacatt aatccatggc ttatgatttg ctcggtcatg 156960 aacaaagtgt gttttaactt caactctaac accttggtag tgtggatgag ctaatacgtc 157020 ccatgcccat tcgtatggat cgttgttact atggtcaaca acttgatcgt tcacgtatcc 157080 atcgagaaaa tctgctacca catactctgc cggtatagca attctgcatc gtttaagaac 157140 gtcaattcta tcttgagatg aatcgatatc taagctatat ctagcagtat caatgatttt 157200 tacttttgct tcacccctta gcttattcaa atctagggta aatgtccgga gttggttcaa 157260 tctctgcagg gctttgttca tcaatgccat aaattcctct gatatgtaat tcaccaaaat 157320 aaacacgatc gtcgtggtta catgtgtctg gttccacaac aaaatcatca ccaagttcta 157380 cgagttcatc acagtgcaac caagcatagt gaacatcacc ttcatgttta accacatgat 157440 ggcaaaacac cgtagccgca tgatgagtac cacgaagatt aacaacttta gaatgagata 157500 cgttaaatgg attaatcatg tttcacccat aataaaagag gagcccgaag gctccttata 157560 attagcgaag ttctgaaccc caacgatcag ttacatcttc taatactacg taaccacatg 157620 tacgcatttt agcatcgttg taatcaaccg ggatagatac tacatcacgc ggatgaactt 157680 taactgaaac aatacggtca gaaccactac cgaagtgacc gatgtaagat ttagagcaga 157740 catgcagacc tgcggaacaa gtacgctgat cgtcttcatc tacctggtta cgcggcattg 157800 taacagtttt accaggagag ttatcaaacg tgtttgaagc acagtccata taagtggaac 157860 gaactacttt ccaaccaatg aagtgaccat catcagtgat gtcgatatcg tttgcattca 157920 ggaaatcaaa cagacgataa actgcacgac gagatgggtt cagcatcagg ttttccagga 157980 aaggcagata acgtttaaag tcttcgccat cttccatagc tcgaacgata cgctcagtca 158040 gaccagattt cagctcgata tctttataga ataaagtacc atcttcaatt cggacgttac 158100 cctgaacgaa tttcttgatg ccttgttcca ggttaatgtg gtcaatagca ccagcgatat 158160 caccatctac aagtttctgc aatgcagatt taaatccagg atgttggcta tcagcattat 158220 aagtagtacg gccttcagta attgaaatga atttggaact tgctgcccat ttaaattcac 158280 gctcaacagg agcttctact ttagcaggaa cattcgccgc agccgctcgg gcttcgcgtt 158340 ctttaaacac acgccgaata gtgtcacggg aaacaccata attctcggcg agctctttct 158400 tagtgtacag accgtttttg aagtttttaa cgattgcatc tttttggatt tcagacagac 158460 aggtaacagc catttattca cctttatttt cagaattttg agtagaagct ccatcaagga 158520 gctccatgat ttttacgata tcattgacga gtttgctgtc agtccgccaa gtatccaaga 158580 cacttgcgat gacaggataa tcatctttaa actgttcaat ctttttatag aagattgtct 158640 cagcatcacc agacagttta ttataaattt tattacataa agctaaatca tcagtttcat 158700 ctttgatttt actggtacgg caaaccttag cgattttgtt tagttttgtc aggaacggat 158760 ttttcattcc agacgctgta aacttactcg acaagaaatt caatttatcg taatgcgcaa 158820 tatttccaca gatacgattt ccagtagcat ttgatggcat gtactggtca taatctacct 158880 tatcaataca cttgatgtat tggtcgataa taaatcggtc aaatgaaagc aatccatcag 158940 cttttgccgc ggctttcata gcacccggac gaattgcata gaatttctta attccacacg 159000 cttctgccag agaccgcatg ctcgcgatgt tcatattcca ccaccaaaca ttatctggga 159060 aagtgtggat ttcatcacga ttacgaccga ttgcataacc ttcaagctca gcaatttcag 159120 atgatactaa agtctgacgg tcttcttccc aatacccgtc tttatcaatc caatgtaatg 159180 acacattagg agatttcgga cgtttctctt ttggaccagt gtcataatca ggaagagctt 159240 ttctctgggc ttcaagttca gacacacgga atactacaac ttcatcagta tccatgattt 159300 tcttcagctc atcaatgaca tgcaattcat cttcattgtc tttgattact gtaatgtgtg 159360 cccagattgg aactaatcca gatttacaca gagctcgaac tgtagcgatg cgtttaccgg 159420 ctttatcatc aataagaaca aacgctttag ttctatcaac cccacaaata tcagaaatgt 159480 ttacttggtt atgacgatgc caagaactgc ttgacacttt acgacgagca ggttcatcac 159540 atgaaacata aaccgacact tcgttatcaa cataatatga acgaatttta tcgagattgt 159600 acttcgcaac aacttgttta atatcgcggt tcccaatggt aataccacgg ctctgaagaa 159660 tagagcgttc cttagaactc agcttattga actcgcgcag gaattcacga tcagattcat 159720 acgcttcaaa cgctttaata tctgcagtaa ttacctcttc ttcaagagca ttcacacgct 159780 tctggatatt ggcaattgtt tcttcatcaa gagaaagctc ttcacgagat ggagtaatgt 159840 ctaattcgcc aagagggaaa tgaacataaa ccttgccata acgattaagc agccaatctg 159900 ccttaacatc tacaccgctg atcggatata cgatttttcc ataaactgcg tacagaccat 159960 agctttcata cgaactatta acgctaaacc aatcagtttt atctactggg aaatattcaa 160020 tttcacggcg aagagaatct acctttggag gtacagcacc aaaggtacgc aaaatatatg 160080 cgatttcata atgccaagta tcaatatctt ctactttaac cggaactgta atttcaagac 160140 cagtttcttc gtcttctttc atgtcatcaa cgaacattgg acgaatagta ggttcacctc 160200 ggtttttcat gacagtataa ccggtggctt taccattatg atatgatact acgttaaatg 160260 tactcgtgta gctcagtgga gatttagaac caagaccaag agcaccgatg aaatcattac 160320 tgttattctt tgtggattca aagaacgttt tatacatcgt catcatgtca ttatgattaa 160380 gacctggacc ataatcacga attacaaatc gtgggtcaag acgagtagga gccttgatat 160440 aaaatggacg attttcatta ccgttcagtt tatgagcatc atcacagtta gtagaaagtt 160500 cacgaacaac agcacgaact ttatacttat agagtttgtt tgacaagatg tcaaaagctt 160560 tacccgaggc cttaatagta aacgttgaat catcagcgtc agaagaacca atgattactt 160620 catcatcaca tttaattttc attttattcc tatcaattat gtcgtttaat gatttctgct 160680 acttcaagga gctcttcagc agtagcggtg ttagttgtaa aaattttatc actgatttgt 160740 ttaaagcggt ctttgaattc ctccgcagct tggacatcaa agaagcgttg gatgatacga 160800 tactcccggt gaatagcatc gtcaaataat tctttatttg gaacataact tttctttagc 160860 attttactgc tcctgatgat ttaatcactt tgaccatgtc ggcaatttta atatcaggac 160920 gcaaaaagcg tatcactttc atagcaaaaa gactgtgatt aatagggaca ctctgattac 160980 tttctaatcg gtcagctata gagtttaata accgcttgat taaaagttct tggtattcat 161040 tggaggggtc gactgagtat tttagtgcct cagtgcggag tattgaaatg atggtagact 161100 tcatgataat ttcctcaaaa aagaggggcc gaagcccctc gggattaatg cactctgcta 161160 acgcggccat acacctcatg tttagaacca tccgagtttt ccacccagat agtaacccaa 161220 gtaccgggaa gaggtttctt ttcggcaaac atgtatccgt aatcgcctga gaccaaagta 161280 atccaataac gttgcatagt aattccttct atagcagggc aatattaccc gtactattta 161340 ttcactcatc caggtcttac gtggagcagc atcgttaccc atgattaatt caaaaagttc 161400 tttccagttt tcaggaagag atactacatc ataaaccggg tcttgaataa cacgctcgta 161460 ttcatcttct tcaagagagc caagaccttt aatataacga agtttccaac ctttgaaatc 161520 atctttatgg tcttcatatt cgccaagaga atagaaccaa cgttgttctt tacctttagt 161580 aagaataata acaggagttt tcacaaagcg gattcgacct tgttcaaata attctggcca 161640 attactaaag aacgccaaaa gacttgggaa aattgaacca acaccatcaa cgtctgcatc 161700 agtcatgatg gcaatatttc gatagttagt attttcagcg ggttcaccga tagtcaaacc 161760 agtgattgca caaatgtcaa atacttcttt attcttcatc gcatccgcag cagacattcc 161820 ccatgtattc atgaacttac cacgcaaagg atatccgcca tgaagttcac ggtcacgagt 161880 tgtaagtaga taaccgatcg cagaatcacc ttcggttaag aataaagttg tgtcagcatc 161940 tttaccatat ttgttggctt tgatgtgctt agctactttg gctttctgtg cctttttagc 162000 agctttagtt tcagcagctt tctctgcagc aagtttacga gctaacatcg cctcaataat 162060 cggcatatga atatcttctg atttcataat agcgttagca agcttcttgt aatcaatatc 162120 aatatgacta cgaatttctc cccaaggaga agtcagacgc tctttagtct gagaatcaaa 162180 tcgcatgtta gacatatcac gaataaacat gatgacagtc aggcattctt taattcgggc 162240 tttgttgact tcaagcttgt acttgcgttt caatgcagga ataagctcat tgctgagttc 162300 atcaagaact aggtcaacgt gagtaccacc atttttggtg tgaatgttat taacatatga 162360 aagttgacgg aacccgtcat ctgagcggcc aatagcaata gcacaagtat cagaatcctg 162420 cactacagca ttttcgtcat acatgtgggc gtaagcttta aacttgcctt gaacccgttt 162480 acccatgaat ttaaattcaa tatcaggata aactactgct aatgtcatca gacggtcatg 162540 aatgatggat tggtcaacat cagttaagcc atcagattca aagtgggtga aatctgggat 162600 aaatgacacg acagtaccag tcttgtcttt aataaattct ttatctttag ctggatgttc 162660 ttcccaagaa acattctctg cgccatttga acagcggaca acgatttcat tttttccatc 162720 acaggttgca cccacaaatg tcacagaaaa aatattcgtt aatgcagaac caacaccgtt 162780 cataccaccg gttttacgct cagcatcatc accaaagtta ccaccggcac gaggacgagt 162840 ccatgcggct acaggtcccg gaatagtttc tccttcaggt gttaccacag gagcctgtgg 162900 aagaccacga ccattatctg ttacaataat tttgttgcct ttaacatcaa ctgaaatctt 162960 attcgcgtgt ttgaaattag tacgaatagc ttcatcaaca gagttatcaa tgatttcatc 163020 aatcagtttg ataataccag gaacatactt tactgattgg aatttaccaa aaagaaaacg 163080 gtcatgcgct tcaaacgcag aactaccaat gtacattccg ctacgcttaa tgatatgttc 163140 tcggtcactc agaattttaa tttcgttctt aatcattaca tttcctcggt tagtgaagga 163200 attatatcaa ctattaatta tagcaagtaa ttcttctttg atatacatca atttgccaag 163260 aacctcatgg cctcctttaa ccgctttata ctctgggtat cgtggccgtt gtcgttcaaa 163320 catagtccat tgagcatcac taacgttagc gtatgcatat cgagaatttc cgtagtactg 163380 ttcaatccgg tactcgttat tttcattaag tgaaatccat tcttcacaga cttcataata 163440 tttctgcatc caaatagtac gaccattcac gtcattgatt ggccaccaag caaacctata 163500 ttttccaata gcccgctcta ccatttttaa ctgtcgttta gcacgccttt gcgcagttgt 163560 cattccaata atcataatat tctcctctgg ccaacaagac tataatacca aaacacgatg 163620 tccatgtaaa caactaaatg acccgaaggt catttattca taacgaattg tgctgttctt 163680 aagaaaaagc cctgagcaca ctgttccgtt aacaggtttt cctgttggtc caatagccgt 163740 aaagcctgtg tgctgaaaat catcctctga gcaagaaaag aacttatatc cggtgatttt 163800 gatatcagta aatcccgcgt tatctaacac acgagttgcg ttatcagcgt cagtgcatcc 163860 aatcatcatg aaggcaagca ctgtaattaa aatctttttc attttaattt aaccctataa 163920 gttatattac ctactttaat aacccggatt tctccgggtt tcatggtaat gcgtgcttta 163980 gttcccatca ataatcaccg ctctttaatc catcgtaatg aactgccgga gcagaaacta 164040 cacgcttcat ttggccttca cacttagggt taaagcagtt aacagtgtag tcacgatggg 164100 aaattttacg cataatttct atcttttttc cacagacttc acacttgtaa tcatacgttg 164160 gcattaacag catccttcca tttttgtgtt ttgactacga tttgctcatt cagtgcacga 164220 gtaaccatca tggagatttc atcatctgat acatgggtat catttttatg gcgatttctg 164280 aaatgcagcc aaagtgcatc cactacacag ttaataacat ctgcgcactc gccttcaaat 164340 tcttctttct gccgccatgg acgattaatc caatcacaca tttctccagt ttctgaagaa 164400 agttgcagca tgacattccc aatgctacga ttaggaatag gataagacat ttttgatgct 164460 tcaaaaatag gagctaaatt taacattgat atgcactctg cagtgctgca atagcagcga 164520 ttgcttgacc acgattatga atagaaagat tcataaccaa atcggttgga attacattcg 164580 cggaagttcc aacttcagta aagtatttga attcgctatc aaaaattaca aggtcttcac 164640 cgccgacttc atcacattct gtgccattag cccacataat tcccgatact ctattatttt 164700 ggtggtcaac tttagtaaca gtaaaactcc cgccattttc atagagttca tacacaaagt 164760 cttcattaac ctcatagcgt gaagaaaatt cttcttcagc ttcatcattg acgaatttgt 164820 actgtacgcc ttctttaaaa ttcattacac aatctccatg tattctgggc catcaactgt 164880 gattacacga gcaaaggtac gaactgggac aatatcacca tggttcgcga atacatacaa 164940 ccaggtccaa tgctcttctt taccgaaggt tttctctttc tgaacgacga ttaagtccgg 165000 gttgaacaga atgtcttcaa aagcttcggc agtaattttt acagtgtttt cagttttcat 165060 gttattctcc tcagtagttg ataagataat agtaccacat ccttgtggca aagtaaacaa 165120 ctttttatac taaaccttga cgttgcgatt ctgtcggctc tacatcggct ttaggcagaa 165180 ctgcatagtt gccttgaaac actacgttta ctagggtttt accgtcttct tcccactcat 165240 cagtgacaag aacattttta tgcagcgaca gattagtggc tgaattagta gaactcaccg 165300 attgggtaat aacattgtca agtgaattca catgtaccca cttgcgcaga tagctttcac 165360 tagattcaac gaattttttc aagcagtgga tgtaatcacc aaaatcttca cggtaaatct 165420 tatacccaga tttaccgtca ttacgattaa ctactttaac gattacacca ttgtgaccaa 165480 cccacttacc accaattact ttaacgtttt cgcctacaac taaatctttc atcgtgtttc 165540 tctcagtttg ttaatgtaga gccattatat aacggctctt tcataaagta aacagctatc 165600 ggtgagaaat ttcacatcca acatcgacgc cgaacagata cccagcttcc caccctttag 165660 ccatcatagc tttggcaacc agaaccatcg ttggagagat ttccgggagg atttcccggt 165720 tgaaccactc ttcaaagttt tcatcgaact caaactcttc cattagccac gccccttagg 165780 taaactcagt ggatcggtat cttctggact tggtgcttcg cttaggccta gcgcataacg 165840 ttgagcatat ttaagcatta gaatatcctt agcgcagtca tggatactat catgcgcaat 165900 aaacccgttg agagtaccct ttggaagagg ggtagttgtc agcccacgag tcagaagcag 165960 cgattcaatt gcagtacgaa tatcacgttg attccagaac ttacagggct cttctttaaa 166020 tgtatcaatt tcttcttcag aaatcccttg agctctctgc acatcgcgaa gacaatctac 166080 aaaaattgga aagtcaaagc tctgcccacg gcaccaacca aaggaatccc atggatgaat 166140 tccattatca atcagatact gctgggcttc tttaattccg gcaattactg ataaatcgtc 166200 tggtgtcgag gcaaggttag cacgggcttc agctgactgt ttcttccacc actcaagagt 166260 agacttacca aataaccgat gacctttctg ggatttaagg tcaaacttaa tacgatgacc 166320 acgtttaacc aattcatcga agctttccag aacttcaggg tcagaatcaa aggtgattag 166380 agcaaggtca atcacagaag agcttgacac atttccgaat gtttcaaaat caataataaa 166440 gtctttagcc attttgagcc tctagcataa atttaatttc gcgtaactgg caaccaatat 166500 attcgctcag atacaccttt gggtcatatc ctgtgaacca agtaatagca ttagcattat 166560 ctgctatatc acgaagctca ttcagaactg tatcaatttt aatgttaata gcacgcttaa 166620 cattatccgg tgcttcaaac ttagattctt gtaagccaac aatcattgtt tgaaggtctt 166680 ctaatttcaa ttcaaacata ttacctcaca catagaatac atcataacga ccacgagtag 166740 taccaacata taataactgt tgcgcgagag aagcatctgc catgtgaatg catggagtat 166800 aaatgaagct tctgtcaatt gagatgccct gggccttatg gaaagtcgaa gccggtaatg 166860 ctttcacttt atgaaactta cgcttagcat cccagaactc agaccaagga gctttacctc 166920 ctttattcca attcttatat gtatctgcag tttttgccaa gaagaattga aacttattca 166980 tttcttcttc ggatgagatg acacagattt tctctctagc gtactcttca tcgtcgccat 167040 aggtttcaat atctaatacc caatgacgaa ccagatattc gcctggaaca cctctggcac 167100 ccaaaaatga tgtggtttca actgcatcta atatgcgaac aaactgacca ttattgaaaa 167160 gaatttcgct gaatttcttt ccttcaaatt taagttcctt ggtaagaggt tcttgcataa 167220 caacaatctc acctactacg aatggccgtt cagtttcata gattctgcgt ctgattattt 167280 cattcaattt atccacagat ttattcgtga acgcaagcat tcggttttca aataaatctt 167340 ctggtgtttt aactaaatta aaataattta gcataaaatc tttaagggca gttcctttcg 167400 taaacccacg gacaccatga ccatcaacta cacagtcgcg aatccaccca ccgtttctga 167460 tttcagtagc aacttcaatg attggagcat tgcttcgcat cacctcggtc aaatgaagtt 167520 gtaagaaatc tttatgagtg aagaatggac tcagtgcagg ttcattactt ccaggttcta 167580 ccggacgtat ctgagcctta tcaccaatgg caatgacaat acaccaggca ggaatagttg 167640 ccatcaaaat cttaaacagc ttacggtcat acattgaagc ttcatcacag atgagaactc 167700 gaatagatgc catatccgga actttctttt gttcaaacag aacgttttct tcatatgtcg 167760 tcgggttaat tttcagaaga ctatgaatag tactggcttg cattccgctt agcttagata 167820 aaaccttttt ggccccatgt gtaggtgctg ccagcgcaat gccagagata ccctgagaaa 167880 tcaaagcgtc aatgataaat ttggttaaag ttgttttacc tgtaccggca ggtccattaa 167940 tcgtaatatg ttgaccttta gctccttgtt tgaccatttc aataacttt 167989

Claims (11)

  1. 폐렴간균(Klebsiella pneumoniae)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 KP1(기탁번호 KFCC11674P).
  2. 제1항에 있어서, 상기 박테리오파지는 pH 3 내지 pH 11의 범위에서 안정한 것을 특징으로 하는 박테리오파지 KP1.
  3. 삭제
  4. 제1항에 있어서, 상기 폐렴간균(Klebsiella pneumoniae)은 베타락탐계 항생제 내성 세균인 ESBL(extended-spectrum bata-lactamase) 폐렴간균(Klebsiella pneumoniae)인, 박테리오파지 KP1.
  5. 제4항에 있어서, 상기 베타락탐계 항생제는 메티실린, 디클록사신, 옥사실린, 플루클록사신, 아목시실린, 암피실린, 피페라실린, 티카실린, 아즐로실린, 카르베니실린, 세팔렉신, 세팔로틴, 세파졸린, 세프테졸, 세파제돈, 세파클러, 세푸록심, 세파맨돌, 세포테탄, 세폭시틴, 세프트리악손, 세프탁심, 세프타지딤, 세파핌, 세프피롬, 이미페넴, 메로페넴, 에르타페넴, 파로페넴 및 아즈트레오남으로 이루어진 군으로부터 하나 이상 선택되는 것을 특징으로 하는 것인, 박테리오파지 KP1.
  6. 제1항의 박테리오파지 KP1을 포함하는, 항생용 조성물.
  7. 제1항의 박테리오파지 KP1을 포함하는, 사료 첨가용 조성물.
  8. 제7항의 사료 첨가용 조성물을 포함하는, 사료.
  9. 제1항의 박테리오파지 KP1을 포함하는, 소독제.
  10. 제1항의 박테리오파지 KP1을 포함하는, 세척제.
  11. 제1항의 박테리오파지 KP1을 인간을 제외한 개체에 투여하는 단계를 포함하는, 폐렴간균(Klebsiella pneumoniae)에 의한 감염성 질병의 예방 또는 치료 방법.
KR1020170169376A 2016-12-22 2017-12-11 신규한 클렙시엘라 속 세균 특이 박테리오파지 kp1 및 이를 포함하는 항균 조성물 KR101993122B1 (ko)

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KR101237233B1 (ko) * 2010-12-15 2013-02-26 주식회사 인트론바이오테크놀로지 녹농균 및 황색포도상구균을 사멸시키는 박테리오파지
KR101726479B1 (ko) 2014-04-24 2017-04-13 이화여자대학교 산학협력단 신규한 클렙시엘라 속 균주 및 이를 포함하는 미생물 연료전지

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