KR101657751B1 - 케토라이드 화합물 - Google Patents
케토라이드 화합물 Download PDFInfo
- Publication number
- KR101657751B1 KR101657751B1 KR1020137016527A KR20137016527A KR101657751B1 KR 101657751 B1 KR101657751 B1 KR 101657751B1 KR 1020137016527 A KR1020137016527 A KR 1020137016527A KR 20137016527 A KR20137016527 A KR 20137016527A KR 101657751 B1 KR101657751 B1 KR 101657751B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- thiadiazol
- pyridin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(c1nnc(-c2ncccn2)[s]1)=O Chemical compound *C(c1nnc(-c2ncccn2)[s]1)=O 0.000 description 9
- QHFXZEIMBZKGPA-UHFFFAOYSA-N BrCc(nc1)ncc1-c1n[o]cc1 Chemical compound BrCc(nc1)ncc1-c1n[o]cc1 QHFXZEIMBZKGPA-UHFFFAOYSA-N 0.000 description 1
- CEAGUSGLAUVBEQ-UHFFFAOYSA-N CC(CC(C1)N(C)C)OC1O Chemical compound CC(CC(C1)N(C)C)OC1O CEAGUSGLAUVBEQ-UHFFFAOYSA-N 0.000 description 1
- SPZUXKZZYDALEY-UHFFFAOYSA-N CC(c1ncccn1)=O Chemical compound CC(c1ncccn1)=O SPZUXKZZYDALEY-UHFFFAOYSA-N 0.000 description 1
- IBWWKWOTFUUVAM-UHFFFAOYSA-N CC(c1nnc(-c2ncccc2)[s]1)OS(c(cc1)ccc1[N+]([O-])=O)(=O)=O Chemical compound CC(c1nnc(-c2ncccc2)[s]1)OS(c(cc1)ccc1[N+]([O-])=O)(=O)=O IBWWKWOTFUUVAM-UHFFFAOYSA-N 0.000 description 1
- CIVCRPSJVLXXSM-FUWLMKHFSA-N CC[Si+](CC)(C(C)CN(C)[C@@H]1CC(OC[C@@](C[C@@H](C)C([C@H](C)[C@@H]([C@@H]2/C(/N)=N/OCc3ccccc3)[C@](C)([C@H](C3C)[O]3C([C@@H]3C)=O)OC2=O)=O)(C[C@@H](C)C3=O)OC)O[C@H](C)C1)O Chemical compound CC[Si+](CC)(C(C)CN(C)[C@@H]1CC(OC[C@@](C[C@@H](C)C([C@H](C)[C@@H]([C@@H]2/C(/N)=N/OCc3ccccc3)[C@](C)([C@H](C3C)[O]3C([C@@H]3C)=O)OC2=O)=O)(C[C@@H](C)C3=O)OC)O[C@H](C)C1)O CIVCRPSJVLXXSM-FUWLMKHFSA-N 0.000 description 1
- QVFNPVLMBMMLFR-ZCFIWIBFSA-N C[C@H](c1nnc(-c2ccccn2)[s]1)O Chemical compound C[C@H](c1nnc(-c2ccccn2)[s]1)O QVFNPVLMBMMLFR-ZCFIWIBFSA-N 0.000 description 1
- LTUNPTMBPLFPKJ-RXMQYKEDSA-N C[C@H](c1nnc(-c2ncccn2)[s]1)O Chemical compound C[C@H](c1nnc(-c2ncccn2)[s]1)O LTUNPTMBPLFPKJ-RXMQYKEDSA-N 0.000 description 1
- YWDNPHMJHAEQEP-SECBINFHSA-N C[C@H](c1nnc(-c2ncccn2)[s]1)OS(c(cc1)ccc1[N+]([O-])=O)(=O)=O Chemical compound C[C@H](c1nnc(-c2ncccn2)[s]1)OS(c(cc1)ccc1[N+]([O-])=O)(=O)=O YWDNPHMJHAEQEP-SECBINFHSA-N 0.000 description 1
- WIQFGRQMBSBCKE-UHFFFAOYSA-N Cc(nc1)ncc1-c1n[o]cc1 Chemical compound Cc(nc1)ncc1-c1n[o]cc1 WIQFGRQMBSBCKE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3352/MUM/2010 | 2010-12-09 | ||
| IN3352MU2010 | 2010-12-09 | ||
| PCT/IB2011/050464 WO2012076989A1 (en) | 2010-12-09 | 2011-02-03 | Ketolide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20130112911A KR20130112911A (ko) | 2013-10-14 |
| KR101657751B1 true KR101657751B1 (ko) | 2016-09-19 |
Family
ID=54259620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137016527A Expired - Fee Related KR101657751B1 (ko) | 2010-12-09 | 2011-02-03 | 케토라이드 화합물 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9175031B2 (https=) |
| EP (2) | EP3216798A3 (https=) |
| JP (2) | JP5851516B2 (https=) |
| KR (1) | KR101657751B1 (https=) |
| CN (2) | CN105669803A (https=) |
| AU (1) | AU2011340204B2 (https=) |
| BR (1) | BR112013014392B1 (https=) |
| CA (2) | CA2820451C (https=) |
| DK (1) | DK2673285T3 (https=) |
| ES (1) | ES2642287T3 (https=) |
| HU (1) | HUE036658T2 (https=) |
| MX (1) | MX348084B (https=) |
| NZ (1) | NZ623574A (https=) |
| PL (1) | PL2673285T3 (https=) |
| PT (1) | PT2673285T (https=) |
| RU (1) | RU2601550C2 (https=) |
| WO (1) | WO2012076989A1 (https=) |
| ZA (1) | ZA201304150B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ587490A (en) * | 2010-08-20 | 2013-03-28 | Greentide Ltd | Anti-Microbial Compounds containing compounds with a sugar substituent |
| CN103619863B (zh) * | 2011-03-22 | 2016-03-16 | 沃克哈特有限公司 | 酮内酯化合物的制备方法 |
| US9346828B2 (en) * | 2013-06-07 | 2016-05-24 | Wisconsin Alumni Research Foundation | Forazolines, compositions thereof and uses thereof |
| ES2774510T3 (es) | 2015-07-27 | 2020-07-21 | Chong Kun Dang Pharmaceutical Corp | Derivados de 1,3,4-oxadiazol sulfamida como inhibidores de histona desacetilasa 6 y composición farmacéutica que comprende los mismos |
| FI3328843T3 (fi) | 2015-07-27 | 2023-01-31 | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| DK3330259T3 (da) * | 2015-07-27 | 2020-08-10 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne |
| RU2709207C2 (ru) | 2015-08-04 | 2019-12-17 | Чонг Кун Данг Фармасьютикал Корп. | 1,3,4-оксадиазольные производные соединения в качестве ингибитора гистондеацетилазы 6 и фармацевтическая композиция, содержащая их |
| HRP20230201T1 (hr) | 2015-10-12 | 2023-03-31 | Chong Kun Dang Pharmaceutical Corp. | Oksadiazol aminski spojevi derivati kao inhibitor histonske deacetilaze 6 i farmaceutska kompozicija koja sadrži iste |
| WO2017122146A1 (en) * | 2016-01-12 | 2017-07-20 | Wockhardt Limited | Pharmaceutical compositions for the treatment of bacterial infections |
| CN108778255B (zh) * | 2016-01-12 | 2020-11-13 | 沃克哈特有限公司 | 药物组合物 |
| WO2017122127A1 (en) * | 2016-01-12 | 2017-07-20 | Wockhardt Limited | Pharmaceutical compositions |
| KR20190129863A (ko) * | 2017-03-16 | 2019-11-20 | 욱크하르트 리미티드 | 케톨라이드 화합물의 제조 방법 |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| AU2020284606B2 (en) | 2019-05-31 | 2023-01-19 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| EP4055011A1 (en) * | 2019-11-05 | 2022-09-14 | Dermira, Inc | Mrgprx2 antagonists and uses thereof |
| CN114845709B (zh) | 2019-11-05 | 2024-10-01 | 德米拉公司 | 用于治疗炎性病症的mrgprx2拮抗剂 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004531471A (ja) | 2000-12-21 | 2004-10-14 | グラクソ グループ リミテッド | マクロライド抗生物質 |
| WO2008023248A2 (en) | 2006-08-24 | 2008-02-28 | Wockhardt Research Centre | Novel macrolides and ketolides having antimicrobial activity |
| WO2009137787A1 (en) | 2008-05-09 | 2009-11-12 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2473525A1 (fr) | 1980-01-11 | 1981-07-17 | Roussel Uclaf | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US4331803A (en) | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| DE69733723T2 (de) | 1996-09-04 | 2006-04-20 | Abbott Laboratories, Abbott Park | 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung |
| WO1999021870A1 (en) * | 1997-10-29 | 1999-05-06 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a 11, 12-carbamate derivatives |
| HRP980189B1 (en) * | 1998-04-06 | 2004-04-30 | Pliva Pharm & Chem Works | Novel 15-membered lactams ketolides |
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| BR0113472A (pt) | 2000-08-22 | 2003-07-01 | Basilea Pharmaceutica Ag | Macrolìdeos com atividade antibacteriana |
| GB0031312D0 (en) | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Macrolides |
| GB0127349D0 (en) | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| US6995143B2 (en) * | 2002-02-28 | 2006-02-07 | Basilea Pharmaceutica Ag | Macrolides with antibacterial activity |
| US6727229B2 (en) | 2002-08-19 | 2004-04-27 | Enanta Pharmaceuticals, Inc. | 11,12-substituted lactone ketolide derivatives having antibacterial activity |
| WO2004108744A2 (en) * | 2003-05-19 | 2004-12-16 | Prasad K Deshpande | Azalides and azaketolides having antimicrobial activity |
| JP2008508322A (ja) * | 2004-07-28 | 2008-03-21 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤としてのケトライド誘導体 |
| ES2691252T3 (es) * | 2007-09-17 | 2018-11-26 | Enanta Pharmaceuticals, Inc. | Macrólidos de biarilo con puente en 6,11 |
| BRPI1011959A2 (pt) * | 2009-05-27 | 2016-04-26 | Wockhardt Research Center | compostos de cetolídeo tendo atividade antimicrobiana. |
-
2011
- 2011-02-03 WO PCT/IB2011/050464 patent/WO2012076989A1/en not_active Ceased
- 2011-02-03 PT PT117080929T patent/PT2673285T/pt unknown
- 2011-02-03 KR KR1020137016527A patent/KR101657751B1/ko not_active Expired - Fee Related
- 2011-02-03 NZ NZ623574A patent/NZ623574A/en not_active IP Right Cessation
- 2011-02-03 PL PL11708092T patent/PL2673285T3/pl unknown
- 2011-02-03 RU RU2013131234/04A patent/RU2601550C2/ru active
- 2011-02-03 ES ES11708092.9T patent/ES2642287T3/es active Active
- 2011-02-03 AU AU2011340204A patent/AU2011340204B2/en not_active Ceased
- 2011-02-03 JP JP2013542630A patent/JP5851516B2/ja not_active Expired - Fee Related
- 2011-02-03 HU HUE11708092A patent/HUE036658T2/hu unknown
- 2011-02-03 CN CN201610004950.0A patent/CN105669803A/zh active Pending
- 2011-02-03 DK DK11708092.9T patent/DK2673285T3/en active
- 2011-02-03 MX MX2013006461A patent/MX348084B/es active IP Right Grant
- 2011-02-03 CA CA2820451A patent/CA2820451C/en not_active Expired - Fee Related
- 2011-02-03 EP EP17164547.6A patent/EP3216798A3/en not_active Withdrawn
- 2011-02-03 BR BR112013014392-4A patent/BR112013014392B1/pt active IP Right Grant
- 2011-02-03 US US13/991,762 patent/US9175031B2/en active Active
- 2011-02-03 CN CN201180066627.1A patent/CN103384676B/zh active Active
- 2011-02-03 CA CA2964104A patent/CA2964104A1/en not_active Abandoned
- 2011-02-03 EP EP11708092.9A patent/EP2673285B1/en active Active
-
2013
- 2013-06-06 ZA ZA2013/04150A patent/ZA201304150B/en unknown
-
2015
- 2015-07-06 JP JP2015135252A patent/JP6102991B2/ja not_active Expired - Fee Related
- 2015-09-19 US US14/859,254 patent/US20160083412A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004531471A (ja) | 2000-12-21 | 2004-10-14 | グラクソ グループ リミテッド | マクロライド抗生物質 |
| WO2008023248A2 (en) | 2006-08-24 | 2008-02-28 | Wockhardt Research Centre | Novel macrolides and ketolides having antimicrobial activity |
| WO2009137787A1 (en) | 2008-05-09 | 2009-11-12 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives |
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| KR101657751B1 (ko) | 케토라이드 화합물 | |
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| KR100369959B1 (ko) | Ｃ-4″-치환된-마크롤리드 유도체 | |
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| CZ9904388A3 (cs) | 9-Oximové deriváty erythromycinu | |
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| NZ611653B (en) | Ketolide compounds |
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