KR101494452B1 - 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 - Google Patents

사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 Download PDF

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KR101494452B1
KR101494452B1 KR1020097013327A KR20097013327A KR101494452B1 KR 101494452 B1 KR101494452 B1 KR 101494452B1 KR 1020097013327 A KR1020097013327 A KR 1020097013327A KR 20097013327 A KR20097013327 A KR 20097013327A KR 101494452 B1 KR101494452 B1 KR 101494452B1
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alkyl
alkylene
isoquinolin
chloro
cyclohexyloxy
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Korean (ko)
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KR20090094110A (ko
Inventor
올리버 플레텐부르크
카트린 로렌츠
요헨 괴를리처
마티아스 뢴
상드린 비스카라
프레데릭 장노
올리비에 뒤클로
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사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
KR1020097013327A 2006-12-27 2007-12-19 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 Expired - Fee Related KR101494452B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026897.6 2006-12-27
EP06026897 2006-12-27
PCT/EP2007/011169 WO2008077556A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives

Publications (2)

Publication Number Publication Date
KR20090094110A KR20090094110A (ko) 2009-09-03
KR101494452B1 true KR101494452B1 (ko) 2015-02-16

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KR1020097013327A Expired - Fee Related KR101494452B1 (ko) 2006-12-27 2007-12-19 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체

Country Status (37)

Country Link
US (1) US8710077B2 (https=)
EP (1) EP2102164B1 (https=)
JP (1) JP5318779B2 (https=)
KR (1) KR101494452B1 (https=)
CN (1) CN101578266B (https=)
AR (1) AR064531A1 (https=)
AT (1) ATE490243T1 (https=)
AU (1) AU2007338412B2 (https=)
BR (1) BRPI0720859A2 (https=)
CA (1) CA2673922C (https=)
CL (1) CL2007003820A1 (https=)
CO (1) CO6210815A2 (https=)
CR (1) CR10811A (https=)
CY (1) CY1111323T1 (https=)
DE (1) DE602007010981D1 (https=)
DK (1) DK2102164T3 (https=)
EC (1) ECSP099468A (https=)
ES (1) ES2355534T3 (https=)
GT (1) GT200900183A (https=)
HR (1) HRP20100705T1 (https=)
MA (1) MA31076B1 (https=)
MX (1) MX2009005967A (https=)
MY (1) MY154767A (https=)
NI (1) NI200900111A (https=)
NO (1) NO20092488L (https=)
NZ (1) NZ577984A (https=)
PL (1) PL2102164T3 (https=)
PT (1) PT2102164E (https=)
RS (1) RS51655B (https=)
RU (1) RU2468011C2 (https=)
SI (1) SI2102164T1 (https=)
SV (1) SV2009003314A (https=)
TN (1) TN2009000274A1 (https=)
TW (1) TWI423803B (https=)
UY (1) UY30845A1 (https=)
WO (1) WO2008077556A1 (https=)
ZA (1) ZA200903555B (https=)

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