KR101483829B1 - 안정한 ｎａｄ/ｎａｄｈ 유도체 - Google Patents

안정한 ｎａｄ/ｎａｄｈ 유도체 Download PDF

Info

Publication number
KR101483829B1
KR101483829B1 KR20127005354A KR20127005354A KR101483829B1 KR 101483829 B1 KR101483829 B1 KR 101483829B1 KR 20127005354 A KR20127005354 A KR 20127005354A KR 20127005354 A KR20127005354 A KR 20127005354A KR 101483829 B1 KR101483829 B1 KR 101483829B1
Authority
KR
South Korea
Prior art keywords
enzyme
dehydrogenase
independently
coenzyme
case
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR20127005354A
Other languages
English (en)
Korean (ko)
Other versions
KR20120044372A (ko
Inventor
요아힘 회네스
디터 하인들
카리나 호른
클라우디아 가에슬러-디트쉐
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20120044372A publication Critical patent/KR20120044372A/ko
Application granted granted Critical
Publication of KR101483829B1 publication Critical patent/KR101483829B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
KR20127005354A 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체 Expired - Fee Related KR101483829B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005035461A DE102005035461A1 (de) 2005-07-28 2005-07-28 Stabile NAD/NADH-Derivate
DE102005035461.0 2005-07-28
PCT/EP2006/007493 WO2007012494A1 (de) 2005-07-28 2006-07-28 Stabile nad/nadh-derivate

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020117002057A Division KR20110028522A (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR20137030825A Division KR101483899B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체

Publications (2)

Publication Number Publication Date
KR20120044372A KR20120044372A (ko) 2012-05-07
KR101483829B1 true KR101483829B1 (ko) 2015-01-16

Family

ID=37137552

Family Applications (4)

Application Number Title Priority Date Filing Date
KR20127005354A Expired - Fee Related KR101483829B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체
KR20137030825A Expired - Fee Related KR101483899B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체
KR1020117002057A Ceased KR20110028522A (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체
KR1020087004422A Expired - Fee Related KR101035524B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR20137030825A Expired - Fee Related KR101483899B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체
KR1020117002057A Ceased KR20110028522A (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체
KR1020087004422A Expired - Fee Related KR101035524B1 (ko) 2005-07-28 2006-07-28 안정한 ｎａｄ/ｎａｄｈ 유도체

Country Status (16)

Country Link
US (3) US8809013B2 (https=)
EP (3) EP2364989B1 (https=)
JP (2) JP5129133B2 (https=)
KR (4) KR101483829B1 (https=)
CN (2) CN101233144B (https=)
AU (2) AU2006274140B8 (https=)
BR (1) BRPI0614217A2 (https=)
CA (2) CA2737123A1 (https=)
DE (1) DE102005035461A1 (https=)
DK (3) DK2364988T3 (https=)
ES (3) ES2453150T3 (https=)
MX (1) MX2008000946A (https=)
PL (3) PL2364988T3 (https=)
PT (3) PT2364988E (https=)
SG (1) SG187511A1 (https=)
WO (1) WO2007012494A1 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7553615B2 (en) * 2005-07-28 2009-06-30 Roche Diagnostics Operations, Inc. Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
EP2022859A1 (de) * 2007-08-01 2009-02-11 Roche Diagnostics GmbH Verfahren und Vorrichtung zur Bestimmung der Konzentration eines Analyten mittels Fluoreszenzmessung
CN101497638B (zh) * 2008-01-30 2012-09-26 中国科学院大连化学物理研究所 一种nad+类似物及其合成和应用
EP2093284A1 (de) * 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
EP2398388B1 (de) * 2009-02-19 2020-04-08 Roche Diabetes Care GmbH Platzsparende magazinierung analytischer hilfsmittel
EP2226007A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Testelementmagazin mit abgedeckten Testfeldern
KR20130127555A (ko) * 2009-02-19 2013-11-22 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
EP2226008A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Magazins
ES2529385T3 (es) 2009-07-27 2015-02-19 F. Hoffmann-La Roche Ag Métodos y sustancias para la obtención de compuestos de piridinio sustituidos sobre N
JP5544423B2 (ja) * 2009-07-27 2014-07-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｎ置換ピリジニウム化合物の調製のための方法及び物質
JP5540096B2 (ja) * 2009-07-27 2014-07-02 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト カルバ−ｎａｄの酵素合成
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
EP2287605A1 (de) 2009-08-20 2011-02-23 Roche Diagnostics GmbH Vereinfachte Magazinierung integrierter Systeme
EP2333544A1 (de) 2009-12-11 2011-06-15 F. Hoffmann-La Roche AG Sterilisierbare Chemie für Testelemente
EP2513648B1 (de) 2009-12-16 2015-05-27 F.Hoffmann-La Roche Ag Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt
KR101252351B1 (ko) * 2010-05-24 2013-04-08 동국대학교 산학협력단 전기효소적 합성 반응을 위한 ｎａｄ(ｐ) 유도체의 전기화학적 환원 방법
CN102453067B (zh) * 2010-10-29 2015-08-05 中国科学院大连化学物理研究所 一种nad+类似物的制备方法及其应用
ES2529023T3 (es) 2011-01-26 2015-02-16 F. Hoffmann-La Roche Ag Método y sustancias para la preparación de compuestos de piridinio N-sustituidos
CN103458786B (zh) 2011-04-12 2015-08-19 霍夫曼-拉罗奇有限公司 分析辅件
US9752990B2 (en) 2013-09-30 2017-09-05 Honeywell International Inc. Low-powered system for driving a fuel control mechanism
CN102863495A (zh) * 2011-07-06 2013-01-09 上海执诚生物科技股份有限公司 一种含有nad+或nadh的稳定的组合物
KR101609083B1 (ko) 2011-09-28 2016-04-04 에프. 호프만-라 로슈 아게 아조 매개체
JP6128808B2 (ja) * 2011-11-15 2017-05-17 栄研化学株式会社 酵素活性の検出、測定方法およびこれを利用したキット
EP2620507A1 (en) 2012-01-25 2013-07-31 Roche Diagnostics GmbH Method for the evaluation of the quality of a test element
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
KR101728597B1 (ko) 2012-04-19 2017-04-19 에프. 호프만-라 로슈 아게 혈액 내 분석물 농도를 결정하는 방법 및 디바이스
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
US8921061B2 (en) * 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
CN104870982B (zh) 2012-12-20 2019-02-15 霍夫曼-拉罗奇有限公司 用于评估医学测量曲线的方法
KR101750638B1 (ko) 2012-12-20 2017-06-23 에프. 호프만-라 로슈 아게 체액의 샘플을 분석하는 방법
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
EP2781919A1 (en) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
HK1213296A1 (zh) * 2013-06-04 2016-06-30 豪夫迈‧罗氏有限公司 用於fret的新化合物及与其相关的方法
EP2811299A1 (en) 2013-06-07 2014-12-10 Roche Diagniostics GmbH Test element for detecting at least one analyte in a body fluid
EP3063169B1 (en) 2013-10-29 2018-10-10 F. Hoffmann-La Roche AG Nano-enzyme containers for test elements
WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
CA2945612C (en) 2014-04-14 2019-09-10 F. Hoffmann-La Roche Ag Phenazinium mediators
CN106687812A (zh) * 2014-08-05 2017-05-17 贝克顿·迪金森公司 用于分析血液样品中的葡萄糖‑6‑磷酸脱氢酶活性的方法和组合物
EP3183246B1 (en) 2014-08-22 2020-09-23 Roche Diagnostics GmbH Redoxindicators
ES2756714T3 (es) 2014-08-25 2020-04-27 Hoffmann La Roche Tira reactiva de dos electrodos que compensan la interferencia
CN108350439A (zh) 2015-12-21 2018-07-31 豪夫迈·罗氏有限公司 来自粪产碱菌的突变体3-羟基丁酸脱氢酶及其相关方法和用途
EP3414325B1 (en) 2016-02-09 2020-01-29 Roche Diabetes Care GmbH Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
CA3035874C (en) 2016-10-05 2025-09-09 F. Hoffmann-La Roche Ag DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTICAL DIAGNOSTIC TEST ELEMENTS, AS WELL AS THEIR METHODS OF USE
EP3339431A1 (en) 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
CN107966555A (zh) * 2017-11-23 2018-04-27 中山市创艺生化工程有限公司 一种用于稳定保存nad或其衍生物的存储液
EP3759231B1 (en) 2018-02-28 2023-10-18 F. Hoffmann-La Roche AG Biocompatibility coating for continuous analyte measurement
CN111217744A (zh) * 2018-11-26 2020-06-02 中国科学院大连化学物理研究所 一种d-氨基酸基nad+类似物及其合成和应用
WO2022132963A1 (en) 2020-12-15 2022-06-23 Abbott Diabetes Care Inc. Nad(p) depot for nad(p)-dependent enzyme-based sensors
WO2025245355A1 (en) 2024-05-24 2025-11-27 Abbott Diabetes Care Inc. Dispensed area and drop solid content tunability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53107486A (en) * 1977-02-28 1978-09-19 Wako Pure Chem Ind Ltd Stabilized nadh aqueous solution
JPS61274636A (ja) 1985-05-30 1986-12-04 西南自動車工業株式会社 活魚水槽
US5801006A (en) 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites
JP4260245B2 (ja) * 1998-06-25 2009-04-30 株式会社三菱化学ヤトロン 還元型ニコチンアミドアデニンジヌクレオチド類の分解を防止する方法及び分解防止用試薬
US6380380B1 (en) 1999-01-04 2002-04-30 Specialty Assays, Inc. Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
AU2001262702A1 (en) 2000-06-07 2001-12-17 Asahi Kasei Kabushiki Kaisha Coenzyme derivatives and enzymes appropriate therefor
KR101002194B1 (ko) 2002-05-16 2011-01-13 에프. 호프만-라 로슈 아게 중합체 층의 제조 방법
DE10221845A1 (de) 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Verfahren und Reagenzsystem mit nicht-regenerierbarem Enzym-Coenzym-Komplex
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biochemistry, Vol.27, No.1, pp.183-193(1988) *

Also Published As

Publication number Publication date
AU2006274140B2 (en) 2010-11-11
KR20080028507A (ko) 2008-03-31
US8809013B2 (en) 2014-08-19
CA2614792A1 (en) 2007-02-01
ES2461624T3 (es) 2014-05-20
EP2364989B1 (de) 2014-03-05
AU2011200465B2 (en) 2012-02-09
DK1907408T3 (da) 2014-06-10
US20140206024A1 (en) 2014-07-24
JP5129133B2 (ja) 2013-01-23
MX2008000946A (es) 2008-03-27
PT1907408E (pt) 2014-03-28
AU2006274140B8 (en) 2011-02-03
DK2364988T3 (da) 2014-05-26
US20160326567A1 (en) 2016-11-10
US20080213809A1 (en) 2008-09-04
ES2461266T3 (es) 2014-05-19
EP2364989A1 (de) 2011-09-14
PL2364988T3 (pl) 2014-08-29
CN103122371B (zh) 2016-12-28
SG187511A1 (en) 2013-02-28
PT2364988E (pt) 2014-04-03
CN103122371A (zh) 2013-05-29
JP5650695B2 (ja) 2015-01-07
ES2453150T3 (es) 2014-04-04
KR20120044372A (ko) 2012-05-07
KR101483899B1 (ko) 2015-01-16
JP2009502844A (ja) 2009-01-29
WO2007012494A1 (de) 2007-02-01
PT2364989E (pt) 2014-04-04
US9399790B2 (en) 2016-07-26
HK1123308A1 (en) 2009-06-12
PL1907408T3 (pl) 2014-07-31
US10167497B2 (en) 2019-01-01
JP2012224638A (ja) 2012-11-15
BRPI0614217A2 (pt) 2011-03-22
AU2011200465A1 (en) 2011-02-24
KR20110028522A (ko) 2011-03-18
KR20140003637A (ko) 2014-01-09
EP1907408B1 (de) 2014-03-05
EP2364988A1 (de) 2011-09-14
CN101233144A (zh) 2008-07-30
DK2364989T3 (da) 2014-06-10
KR101035524B1 (ko) 2011-05-23
DE102005035461A1 (de) 2007-02-15
AU2006274140A1 (en) 2007-02-01
EP2364988B1 (de) 2014-02-26
WO2007012494B1 (de) 2007-03-29
EP1907408A1 (de) 2008-04-09
CA2737123A1 (en) 2007-02-01
PL2364989T3 (pl) 2014-08-29
CA2614792C (en) 2011-07-12
CN101233144B (zh) 2013-02-06

Similar Documents

Publication Publication Date Title
KR101483829B1 (ko) 안정한 ｎａｄ/ｎａｄｈ 유도체
US9139572B2 (en) Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
JP5758128B2 (ja) 安定な補酵素による脱水素酵素の安定化
AU2012201023B2 (en) Stable NAD/NADH derivatives
HK1181078A (en) Stable nad/nadh derivatives
HK1123308B (en) Stable nad/nadh derivatives

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

A107 Divisional application of patent
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

Fee payment year number: 1

St.27 status event code: A-2-2-U10-U12-oth-PR1002

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

Not in force date: 20180113

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

St.27 status event code: A-4-4-U10-U13-oth-PC1903

PC1903 Unpaid annual fee

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20180113

St.27 status event code: N-4-6-H10-H13-oth-PC1903

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000