KR101426180B1 - 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 - Google Patents

디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 Download PDF

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KR101426180B1
KR101426180B1 KR1020127014234A KR20127014234A KR101426180B1 KR 101426180 B1 KR101426180 B1 KR 101426180B1 KR 1020127014234 A KR1020127014234 A KR 1020127014234A KR 20127014234 A KR20127014234 A KR 20127014234A KR 101426180 B1 KR101426180 B1 KR 101426180B1
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compound
phenyl
bicyclo
benzyl
dioxa
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KR20120093321A (ko
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빈센트 마스시티
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화이자 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020127014234A 2009-11-02 2010-10-21 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 Active KR101426180B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25714009P 2009-11-02 2009-11-02
US61/257,140 2009-11-02
US37293810P 2010-08-12 2010-08-12
US61/372,938 2010-08-12
PCT/IB2010/054775 WO2011051864A1 (en) 2009-11-02 2010-10-21 Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives

Publications (2)

Publication Number Publication Date
KR20120093321A KR20120093321A (ko) 2012-08-22
KR101426180B1 true KR101426180B1 (ko) 2014-07-31

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KR1020127014234A Active KR101426180B1 (ko) 2009-11-02 2010-10-21 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체

Country Status (22)

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US (5) US8669380B2 (enExample)
EP (1) EP2496583B1 (enExample)
JP (1) JP5696156B2 (enExample)
KR (1) KR101426180B1 (enExample)
AP (1) AP3099A (enExample)
AU (1) AU2010310956B2 (enExample)
CA (1) CA2777857C (enExample)
CR (1) CR20120289A (enExample)
DK (1) DK2496583T3 (enExample)
EA (1) EA021983B1 (enExample)
EC (1) ECSP12011946A (enExample)
ES (1) ES2527179T3 (enExample)
GE (1) GEP20146104B (enExample)
HR (1) HRP20150107T1 (enExample)
ME (1) ME02016B (enExample)
NZ (1) NZ599945A (enExample)
PL (1) PL2496583T3 (enExample)
PT (1) PT2496583E (enExample)
RS (1) RS53827B1 (enExample)
SI (1) SI2496583T1 (enExample)
WO (1) WO2011051864A1 (enExample)
ZA (1) ZA201203486B (enExample)

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UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
PT2934568T (pt) 2012-12-21 2018-01-04 Sanofi Sa Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina
ES2740299T3 (es) * 2013-03-14 2020-02-05 Msd Int Gmbh Métodos para preparar inhibidores de SGLT2
WO2014187365A1 (zh) * 2013-05-24 2014-11-27 四川海思科制药有限公司 氧杂双环衍生物、制备方法及其应用
WO2015027963A1 (zh) * 2013-09-02 2015-03-05 四川海思科制药有限公司 芳环类衍生物、其药物组合物及其应用
ES2605886T3 (es) * 2013-09-27 2017-03-16 Sunshine Lake Pharma Co., Ltd. Derivados de glucopiranosilo y sus usos en medicina
SG11201608936UA (en) * 2014-05-19 2016-12-29 Pfizer Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of asgpr
CN105461762B (zh) * 2014-09-27 2018-12-04 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其在医药上的应用
RS62275B1 (sr) 2015-03-03 2021-09-30 Saniona As Kombinovana formulacija tesofensina i metoprolola
CN105646604A (zh) * 2016-03-01 2016-06-08 孙霖 埃格列净晶型b及制备方法
CN105646603A (zh) * 2016-03-01 2016-06-08 孙霖 埃格列净晶型a及制备方法
CN107382952B (zh) * 2017-07-13 2020-02-28 杭州科巢生物科技有限公司 埃格列净的制备方法及其中间体
CN107857768A (zh) * 2018-01-04 2018-03-30 威海贯标信息科技有限公司 一种埃格列净新晶型
WO2020026273A1 (en) * 2018-07-31 2020-02-06 Msn Laboratories Private Limited, R&D Center Solid forms of ertugliflozin free base and solid dispersions comprising ertugliflozin l-pyroglutamic acid.
CN111269241A (zh) * 2018-12-05 2020-06-12 广西久福生物科技有限公司 一种新型化合物及其制备方法与应用
WO2021137144A1 (en) * 2019-12-31 2021-07-08 Hikal Limited An efficient process for the preparation of ertugliflozin l-pyroglutamic acid and intermediates thereof
CN113214263B (zh) * 2020-02-06 2022-09-30 北京桦冠医药科技有限公司 瑞德西韦关键中间体的一种合成方法
CN117624265A (zh) * 2023-11-27 2024-03-01 江苏海悦康医药科技有限公司 艾托格列净杂质的合成方法

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