KR101378716B1 - Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 - Google Patents

Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 Download PDF

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Publication number
KR101378716B1
KR101378716B1 KR1020077029798A KR20077029798A KR101378716B1 KR 101378716 B1 KR101378716 B1 KR 101378716B1 KR 1020077029798 A KR1020077029798 A KR 1020077029798A KR 20077029798 A KR20077029798 A KR 20077029798A KR 101378716 B1 KR101378716 B1 KR 101378716B1
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South Korea
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alkyl
group
substituted
aryl
unsubstituted
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KR20080059112A (ko
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오스카 마리오 사베드라
스테펜 윌리엄 클라릿지
리지에 지한
프랭크 래펠
아카디 바이스버그
스테판 래펠
로버트 데지엘
미첼 맨니온
낸시 제트. 조우
프리데릭 가우데트
뤼보미어 이사코빅
아말 와하브
마리-끌로드 그랜저
노에미 베른스테인
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메틸진 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020077029798A 2005-05-20 2006-05-19 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 Active KR101378716B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68303605P 2005-05-20 2005-05-20
US60/683,036 2005-05-20
US75490205P 2005-12-29 2005-12-29
US60/754,902 2005-12-29
US78505406P 2006-03-22 2006-03-22
US60/785,054 2006-03-22
PCT/IB2006/004306 WO2008041053A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (2)

Publication Number Publication Date
KR20080059112A KR20080059112A (ko) 2008-06-26
KR101378716B1 true KR101378716B1 (ko) 2014-04-10

Family

ID=39190471

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077029798A Active KR101378716B1 (ko) 2005-05-20 2006-05-19 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제

Country Status (13)

Country Link
US (2) US8093264B2 (https=)
EP (1) EP1957498B1 (https=)
JP (1) JP5148499B2 (https=)
KR (1) KR101378716B1 (https=)
CN (1) CN101796055B (https=)
AU (1) AU2006343808B2 (https=)
BR (1) BRPI0610322B8 (https=)
CA (1) CA2611370C (https=)
ES (1) ES2623221T3 (https=)
IL (1) IL187484A (https=)
MX (1) MX2007014616A (https=)
NZ (1) NZ564283A (https=)
WO (1) WO2008041053A2 (https=)

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TW201811795A (zh) 2016-08-24 2018-04-01 美商亞闊股份有限公司 胺基－吡咯并嘧啶酮化合物及其用途
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
CN113336768B (zh) * 2020-02-18 2022-08-19 深圳海王医药科技研究院有限公司 一种多靶点酪氨酸激酶抑制剂
CN114957136A (zh) * 2021-02-24 2022-08-30 南京科默生物医药有限公司 一种用作vegfr抑制剂的抗肿瘤化合物及其用途
CN115215803B (zh) * 2022-09-19 2022-12-30 苏州美诺医药科技有限公司 一种4-卤代-1-(二氟甲基)-1h-咪唑的制备方法
CN117902987A (zh) * 2024-01-22 2024-04-19 安庆双启医药科技有限公司 一种3-氟-5-碘苯胺的制备方法
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Also Published As

Publication number Publication date
IL187484A (en) 2014-04-30
BRPI0610322B1 (pt) 2020-12-01
CN101796055A (zh) 2010-08-04
CN101796055B (zh) 2013-09-04
KR20080059112A (ko) 2008-06-26
EP1957498A4 (en) 2010-10-27
AU2006343808A1 (en) 2008-04-10
US8329726B2 (en) 2012-12-11
IL187484A0 (en) 2011-08-01
WO2008041053A2 (en) 2008-04-10
JP5148499B2 (ja) 2013-02-20
MX2007014616A (es) 2009-08-12
US20120083482A1 (en) 2012-04-05
JP2009504804A (ja) 2009-02-05
BRPI0610322A2 (pt) 2010-06-15
EP1957498B1 (en) 2017-02-15
US20070004675A1 (en) 2007-01-04
NZ564283A (en) 2011-07-29
CA2611370C (en) 2014-11-25
EP1957498A2 (en) 2008-08-20
WO2008041053A3 (en) 2009-12-23
AU2006343808B2 (en) 2012-03-29
US8093264B2 (en) 2012-01-10
CA2611370A1 (en) 2006-11-20
BRPI0610322B8 (pt) 2021-05-25
ES2623221T3 (es) 2017-07-10

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