KR101353117B1 - 항-페로포틴 １ 모노클로날 항체 및 이의 용도 - Google Patents

항-페로포틴 １ 모노클로날 항체 및 이의 용도

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Publication number
KR101353117B1
KR101353117B1 KR1020117014053A KR20117014053A KR101353117B1 KR 101353117 B1 KR101353117 B1 KR 101353117B1 KR 1020117014053 A KR1020117014053 A KR 1020117014053A KR 20117014053 A KR20117014053 A KR 20117014053A KR 101353117 B1 KR101353117 B1 KR 101353117B1
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KR
South Korea
Prior art keywords
seq
mab
fpn1
amino acid
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020117014053A
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English (en)
Korean (ko)
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KR20110084996A (ko
Inventor
돈미엔느 든 문 렁
펭 루안
조세프 빈센트 마네타
잉 탕
데릭 리안 윗쳐
Original Assignee
일라이 릴리 앤드 캄파니
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Application filed by 일라이 릴리 앤드 캄파니 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR20110084996A publication Critical patent/KR20110084996A/ko
Application granted granted Critical
Publication of KR101353117B1 publication Critical patent/KR101353117B1/ko
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020117014053A 2008-12-05 2009-12-01 항-페로포틴 １ 모노클로날 항체 및 이의 용도 Expired - Fee Related KR101353117B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12007608P 2008-12-05 2008-12-05
US61/120,076 2008-12-05
US23981809P 2009-09-04 2009-09-04
US61/239,818 2009-09-04
PCT/US2009/066187 WO2010065496A1 (en) 2008-12-05 2009-12-01 Anti-ferroportin 1 monoclonal antibodies and uses thereof

Publications (2)

Publication Number Publication Date
KR20110084996A KR20110084996A (ko) 2011-07-26
KR101353117B1 true KR101353117B1 (ko) 2014-02-17

Family

ID=41683589

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117014053A Expired - Fee Related KR101353117B1 (ko) 2008-12-05 2009-12-01 항-페로포틴 １ 모노클로날 항체 및 이의 용도

Country Status (25)

Country Link
EP (1) EP2373335B1 (enExample)
JP (1) JP5713917B2 (enExample)
KR (1) KR101353117B1 (enExample)
CN (1) CN102238962B (enExample)
AR (1) AR074398A1 (enExample)
AU (1) AU2009322587B2 (enExample)
BR (1) BRPI0922288A2 (enExample)
CA (1) CA2745618C (enExample)
CY (1) CY1117355T1 (enExample)
DK (1) DK2373335T3 (enExample)
EA (1) EA020472B1 (enExample)
ES (1) ES2566343T3 (enExample)
HR (1) HRP20160302T1 (enExample)
HU (1) HUE028585T2 (enExample)
IL (1) IL212731A0 (enExample)
MX (1) MX2011005939A (enExample)
NZ (1) NZ592545A (enExample)
PA (1) PA8849601A1 (enExample)
PL (1) PL2373335T3 (enExample)
SG (1) SG171960A1 (enExample)
SI (1) SI2373335T1 (enExample)
TW (1) TW201023891A (enExample)
UA (1) UA104741C2 (enExample)
WO (1) WO2010065496A1 (enExample)
ZA (1) ZA201103941B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104284677A (zh) * 2012-05-14 2015-01-14 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
EP3788065B1 (en) 2018-04-30 2025-08-27 The Children's Hospital Of Philadelphia Improving anemias by combining agents
KR20220088699A (ko) 2019-09-27 2022-06-28 디스크 메디슨, 인크. 골수섬유증 및 관련 상태의 치료 방법
CN110806486B (zh) * 2019-11-23 2023-03-21 中南大学湘雅三医院 Mafg/as1/pcbp2/fpn1调控轴作为靶位点检测试剂的应用
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
CN113980987A (zh) * 2021-12-06 2022-01-28 上海市农业科学院 一种提高植物抗镍性能的PgIREG1S和AlATP-PRTS双基因组及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166448B1 (en) 1999-05-10 2007-01-23 Children's Medical Center Corproation Ferroportin1 nucleic acids and proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319221B1 (it) * 2000-10-17 2003-09-26 Antonello Pietrangelo Mutazioni nel gene della ferroportina 1 associata ad emocromatosiereditaria.
CA2711826C (en) * 2008-01-25 2018-02-27 Amgen Inc. Ferroportin antibodies and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166448B1 (en) 1999-05-10 2007-01-23 Children's Medical Center Corproation Ferroportin1 nucleic acids and proteins

Also Published As

Publication number Publication date
MX2011005939A (es) 2011-06-27
EP2373335B1 (en) 2016-02-24
JP2012510814A (ja) 2012-05-17
AR074398A1 (es) 2011-01-12
ES2566343T3 (es) 2016-04-12
CN102238962A (zh) 2011-11-09
JP5713917B2 (ja) 2015-05-07
ZA201103941B (en) 2012-11-28
NZ592545A (en) 2012-12-21
AU2009322587B2 (en) 2013-09-26
TW201023891A (en) 2010-07-01
DK2373335T3 (en) 2016-05-02
HRP20160302T1 (hr) 2016-04-22
PA8849601A1 (es) 2010-07-27
CN102238962B (zh) 2014-02-12
HK1158977A1 (zh) 2012-07-27
UA104741C2 (uk) 2014-03-11
CA2745618A1 (en) 2010-06-10
BRPI0922288A2 (pt) 2018-08-28
EA020472B1 (ru) 2014-11-28
EP2373335A1 (en) 2011-10-12
CY1117355T1 (el) 2017-04-26
AU2009322587A1 (en) 2011-07-28
SI2373335T1 (sl) 2016-04-29
IL212731A0 (en) 2011-07-31
SG171960A1 (en) 2011-07-28
KR20110084996A (ko) 2011-07-26
WO2010065496A1 (en) 2010-06-10
PL2373335T3 (pl) 2016-08-31
EA201170764A1 (ru) 2011-12-30
CA2745618C (en) 2014-06-10
HUE028585T2 (en) 2016-12-28

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