EA020472B1 - Моноклональные антитела против ферропортина 1 и их применение - Google Patents

Моноклональные антитела против ферропортина 1 и их применение Download PDF

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Publication number
EA020472B1
EA020472B1 EA201170764A EA201170764A EA020472B1 EA 020472 B1 EA020472 B1 EA 020472B1 EA 201170764 A EA201170764 A EA 201170764A EA 201170764 A EA201170764 A EA 201170764A EA 020472 B1 EA020472 B1 EA 020472B1
Authority
EA
Eurasian Patent Office
Prior art keywords
zeo
amino acid
mat
human
hepcidin
Prior art date
Application number
EA201170764A
Other languages
English (en)
Russian (ru)
Other versions
EA201170764A1 (ru
Inventor
Донмьенн Доэн Мун Льюнг
Пэн Луань
Джозеф Винсент Манетта
Ин Тан
Деррик Райан Уитчер
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201170764A1 publication Critical patent/EA201170764A1/ru
Publication of EA020472B1 publication Critical patent/EA020472B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA201170764A 2008-12-05 2009-12-01 Моноклональные антитела против ферропортина 1 и их применение EA020472B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12007608P 2008-12-05 2008-12-05
US23981809P 2009-09-04 2009-09-04
PCT/US2009/066187 WO2010065496A1 (en) 2008-12-05 2009-12-01 Anti-ferroportin 1 monoclonal antibodies and uses thereof

Publications (2)

Publication Number Publication Date
EA201170764A1 EA201170764A1 (ru) 2011-12-30
EA020472B1 true EA020472B1 (ru) 2014-11-28

Family

ID=41683589

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170764A EA020472B1 (ru) 2008-12-05 2009-12-01 Моноклональные антитела против ферропортина 1 и их применение

Country Status (25)

Country Link
EP (1) EP2373335B1 (enExample)
JP (1) JP5713917B2 (enExample)
KR (1) KR101353117B1 (enExample)
CN (1) CN102238962B (enExample)
AR (1) AR074398A1 (enExample)
AU (1) AU2009322587B2 (enExample)
BR (1) BRPI0922288A2 (enExample)
CA (1) CA2745618C (enExample)
CY (1) CY1117355T1 (enExample)
DK (1) DK2373335T3 (enExample)
EA (1) EA020472B1 (enExample)
ES (1) ES2566343T3 (enExample)
HR (1) HRP20160302T1 (enExample)
HU (1) HUE028585T2 (enExample)
IL (1) IL212731A0 (enExample)
MX (1) MX2011005939A (enExample)
NZ (1) NZ592545A (enExample)
PA (1) PA8849601A1 (enExample)
PL (1) PL2373335T3 (enExample)
SG (1) SG171960A1 (enExample)
SI (1) SI2373335T1 (enExample)
TW (1) TW201023891A (enExample)
UA (1) UA104741C2 (enExample)
WO (1) WO2010065496A1 (enExample)
ZA (1) ZA201103941B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014027905A2 (pt) * 2012-05-14 2017-06-27 Genentech Inc anticorpo, célula, ácido nucleico, métodos de identificação de um primeiro anticorpo, de inibição do crescimento de uma célula, de tratamento terapêutico, de determinação da presença de uma proteína, de diagnóstico da presença de um tumor e de distribuição de agente citotóxico.
WO2019213016A1 (en) 2018-04-30 2019-11-07 The Children's Hospital Of Philadelphia Methods of improving anemias by combining agents
CA3156007A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS
CN110806486B (zh) * 2019-11-23 2023-03-21 中南大学湘雅三医院 Mafg/as1/pcbp2/fpn1调控轴作为靶位点检测试剂的应用
AU2021273014A1 (en) 2020-05-13 2022-11-17 AbbVie Deutschland GmbH & Co. KG Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease
ES3075793T3 (en) 2020-05-13 2026-08-07 Disc Medicine Inc Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
CN113980987A (zh) * 2021-12-06 2022-01-28 上海市农业科学院 一种提高植物抗镍性能的PgIREG1S和AlATP-PRTS双基因组及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166448B1 (en) * 1999-05-10 2007-01-23 Children's Medical Center Corproation Ferroportin1 nucleic acids and proteins
WO2009094551A1 (en) * 2008-01-25 2009-07-30 Amgen Inc. Ferroportin antibodies and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319221B1 (it) * 2000-10-17 2003-09-26 Antonello Pietrangelo Mutazioni nel gene della ferroportina 1 associata ad emocromatosiereditaria.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166448B1 (en) * 1999-05-10 2007-01-23 Children's Medical Center Corproation Ferroportin1 nucleic acids and proteins
WO2009094551A1 (en) * 2008-01-25 2009-07-30 Amgen Inc. Ferroportin antibodies and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUNN ET AL.: "Iron uptake and metabolism in the new millennium", TRENDS IN CELL BIOLOGY, ELSEVIER SCIENCE, LTD., XX, vol. 17, no. 2, 6 February 2007 (2007-02-06), pages 93-100, XP005876274, ISSN: 0962-8924, figure 1 *
NEMETH ELIZABETA ET AL.: "Regulation of iron metabolism by hepcidin", ANNUAL REVIEW OF NUTRITION 2006, vol. 26, 2006, pages 323-342, XP002570407, ISSN: 0199-9885 *

Also Published As

Publication number Publication date
WO2010065496A1 (en) 2010-06-10
AR074398A1 (es) 2011-01-12
JP2012510814A (ja) 2012-05-17
CA2745618C (en) 2014-06-10
JP5713917B2 (ja) 2015-05-07
CA2745618A1 (en) 2010-06-10
AU2009322587A1 (en) 2011-07-28
EA201170764A1 (ru) 2011-12-30
HUE028585T2 (en) 2016-12-28
HK1158977A1 (zh) 2012-07-27
KR20110084996A (ko) 2011-07-26
UA104741C2 (uk) 2014-03-11
AU2009322587B2 (en) 2013-09-26
CN102238962A (zh) 2011-11-09
SG171960A1 (en) 2011-07-28
KR101353117B1 (ko) 2014-02-17
EP2373335A1 (en) 2011-10-12
MX2011005939A (es) 2011-06-27
IL212731A0 (en) 2011-07-31
TW201023891A (en) 2010-07-01
PL2373335T3 (pl) 2016-08-31
SI2373335T1 (sl) 2016-04-29
HRP20160302T1 (hr) 2016-04-22
NZ592545A (en) 2012-12-21
ES2566343T3 (es) 2016-04-12
BRPI0922288A2 (pt) 2018-08-28
DK2373335T3 (en) 2016-05-02
CN102238962B (zh) 2014-02-12
ZA201103941B (en) 2012-11-28
PA8849601A1 (es) 2010-07-27
EP2373335B1 (en) 2016-02-24
CY1117355T1 (el) 2017-04-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KZ RU