KR101346823B1 - 헤테로시클릭 화합물 - Google Patents
헤테로시클릭 화합물 Download PDFInfo
- Publication number
- KR101346823B1 KR101346823B1 KR1020087007856A KR20087007856A KR101346823B1 KR 101346823 B1 KR101346823 B1 KR 101346823B1 KR 1020087007856 A KR1020087007856 A KR 1020087007856A KR 20087007856 A KR20087007856 A KR 20087007856A KR 101346823 B1 KR101346823 B1 KR 101346823B1
- Authority
- KR
- South Korea
- Prior art keywords
- ethyl
- hydroxy
- acrylamide
- benzoimidazol
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C*C(*)(C(*)(*)N(C)*)N(C1C=C=*)C(C)=N[C@]1C=CC Chemical compound C*C(*)(C(*)(*)N(C)*)N(C1C=C=*)C(C)=N[C@]1C=CC 0.000 description 9
- HZHTZGZFACSSDG-PLNGDYQASA-N N/C(/C=C=[IH])=C(/C=[IH])\[N+]([O-])=O Chemical compound N/C(/C=C=[IH])=C(/C=[IH])\[N+]([O-])=O HZHTZGZFACSSDG-PLNGDYQASA-N 0.000 description 2
- GQVZZIGSSJLRHG-CSKARUKUSA-N CC(C)c1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CC(C)(C)CN(C)C Chemical compound CC(C)c1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CC(C)(C)CN(C)C GQVZZIGSSJLRHG-CSKARUKUSA-N 0.000 description 1
- JVWWTPUNBWTSOK-SXOVAMJMSA-N CC/C=C\CCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC Chemical compound CC/C=C\CCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC JVWWTPUNBWTSOK-SXOVAMJMSA-N 0.000 description 1
- WSYLVMMIJSNYOO-ZRDIBKRKSA-N CCCCCCCC(Cc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN)OC Chemical compound CCCCCCCC(Cc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN)OC WSYLVMMIJSNYOO-ZRDIBKRKSA-N 0.000 description 1
- AMIKPLQPRZKGPT-ACCUITESSA-N CCCCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNC Chemical compound CCCCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNC AMIKPLQPRZKGPT-ACCUITESSA-N 0.000 description 1
- WHNLIRMCHUMPQS-ZRDIBKRKSA-N CCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1C1CNCCC1 Chemical compound CCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1C1CNCCC1 WHNLIRMCHUMPQS-ZRDIBKRKSA-N 0.000 description 1
- DTAZWJVJAYHIQI-WYMLVPIESA-N CCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC Chemical compound CCCCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC DTAZWJVJAYHIQI-WYMLVPIESA-N 0.000 description 1
- FJLDUQSFSRCILW-ACCUITESSA-N CCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1C1CCN(Cc2ccccc2)CC1 Chemical compound CCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1C1CCN(Cc2ccccc2)CC1 FJLDUQSFSRCILW-ACCUITESSA-N 0.000 description 1
- ADLOOPCDYMHBCL-CSKARUKUSA-N CCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNCC Chemical compound CCCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNCC ADLOOPCDYMHBCL-CSKARUKUSA-N 0.000 description 1
- IGWFCLSNTJQSHF-VQHVLOKHSA-N CCCN(CC[n]1c(ccc(/C=C/C(NO)=O)c2)c2nc1)CC(C)(C)C Chemical compound CCCN(CC[n]1c(ccc(/C=C/C(NO)=O)c2)c2nc1)CC(C)(C)C IGWFCLSNTJQSHF-VQHVLOKHSA-N 0.000 description 1
- DAVSOCTXEJCHQN-CSKARUKUSA-N CCCNc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC Chemical compound CCCNc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCN(CC)CC DAVSOCTXEJCHQN-CSKARUKUSA-N 0.000 description 1
- LSEVLUVTDBFLIS-CSKARUKUSA-N CCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNCCC(C)(C)C Chemical compound CCCc1nc(cc(/C=C/C(NO)=O)cc2)c2[n]1CCNCCC(C)(C)C LSEVLUVTDBFLIS-CSKARUKUSA-N 0.000 description 1
Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| US78381906P | 2006-03-21 | 2006-03-21 | |
| US60/783,819 | 2006-03-21 | ||
| PCT/SG2006/000217 WO2007030080A1 (en) | 2005-09-08 | 2006-08-01 | Heterocyclic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7781595B2 (en) | 2003-09-22 | 2010-08-24 | S*Bio Pte Ltd. | Benzimidazole derivatives: preparation and pharmaceutical applications |
| DE102007037579B4 (de) | 2007-08-09 | 2012-05-16 | Emc Microcollections Gmbh | Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe |
| WO2009084544A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
| US20110212943A1 (en) * | 2008-10-15 | 2011-09-01 | Orchid Research Laboratories Limited | Novel bridged cyclic compounds as histone deacetylase inhibitors |
| KR101168801B1 (ko) * | 2009-03-27 | 2012-07-25 | 주식회사종근당 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
| US20110245154A1 (en) * | 2010-03-11 | 2011-10-06 | Hemaquest Pharmaceuticals, Inc. | Methods and Compositions for Treating Viral or Virally-Induced Conditions |
| PT2624696T (pt) | 2010-10-06 | 2017-03-21 | Glaxosmithkline Llc | Derivados de benzimidazole como inibidores da cinase pi3 |
| CA2866333C (en) * | 2011-03-09 | 2020-12-29 | Cereno Scientific Ab | Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors |
| WO2012127466A1 (en) * | 2011-03-24 | 2012-09-27 | Bar Ilan University | 5-aminolevulinic acid derivatives, methods for their preparation and uses thereof |
| US20150258068A1 (en) * | 2012-10-30 | 2015-09-17 | Mei Pharma, Inc. | Combination therapies |
| GB201417828D0 (en) | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
| US10723705B2 (en) | 2015-08-14 | 2020-07-28 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| CN114209667A (zh) | 2016-04-08 | 2022-03-22 | 赛伦诺科技有限公司 | 包含丙戊酸的延迟释放药物制剂和其用途 |
| AR108257A1 (es) | 2016-05-02 | 2018-08-01 | Mei Pharma Inc | Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas |
| EP3728205A1 (en) | 2017-12-19 | 2020-10-28 | Assia Chemical Industries Ltd | Crystalline polymorphs of pracinostat and pracinostat salts |
| KR102106032B1 (ko) * | 2018-08-24 | 2020-04-29 | 인제대학교산학협력단 | 프라시노스타트를 포함하는 다발성 경화증 치료용 약학 조성물 |
| KR102162744B1 (ko) * | 2018-09-18 | 2020-10-07 | 인제대학교산학협력단 | 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물 |
| CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
| SG11202113215UA (en) | 2019-05-31 | 2021-12-30 | Viracta Subsidiary Inc | Methods of treating virally associated cancers with histone deacetylase inhibitors |
| WO2021217180A1 (en) * | 2020-04-22 | 2021-10-28 | Johnson Matthey Public Limited Company | Novel forms of pracinostat dihydrochloride |
Citations (1)
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| WO2005028447A1 (en) * | 2003-09-22 | 2005-03-31 | S*Bio Pte Ltd | Benzimidazole derivates: preparation and pharmaceutical applications |
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| EP1608628A2 (en) * | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AR043850A1 (es) * | 2003-04-17 | 2005-08-17 | Bayer Pharmaceuticals Corp | Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos |
| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005028447A1 (en) * | 2003-09-22 | 2005-03-31 | S*Bio Pte Ltd | Benzimidazole derivates: preparation and pharmaceutical applications |
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| BRPI0615690B8 (pt) | 2021-05-25 |
| EP1937650B1 (en) | 2011-06-15 |
| TWI393708B (zh) | 2013-04-21 |
| JP5207064B2 (ja) | 2013-06-12 |
| CY1111789T1 (el) | 2015-10-07 |
| PT1937650E (pt) | 2011-09-21 |
| TW200745047A (en) | 2007-12-16 |
| JP2009507829A (ja) | 2009-02-26 |
| PL1937650T3 (pl) | 2011-11-30 |
| HK1123038A1 (en) | 2009-06-05 |
| BRPI0615690B1 (pt) | 2020-12-08 |
| BRPI0615690A2 (pt) | 2011-05-24 |
| US20090048300A1 (en) | 2009-02-19 |
| ATE512953T1 (de) | 2011-07-15 |
| DK1937650T3 (da) | 2011-10-03 |
| US8143282B2 (en) | 2012-03-27 |
| EP1937650A1 (en) | 2008-07-02 |
| AR055364A1 (es) | 2007-08-22 |
| MY144970A (en) | 2011-11-30 |
| KR20080046219A (ko) | 2008-05-26 |
| EP1937650A4 (en) | 2010-02-24 |
| WO2007030080A1 (en) | 2007-03-15 |
| NZ594108A (en) | 2012-12-21 |
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