KR101240464B1 - 위장 및 중추 신경계 장애를 치료하기 위한 입체이성체적화합물 및 그 치료방법 - Google Patents

위장 및 중추 신경계 장애를 치료하기 위한 입체이성체적화합물 및 그 치료방법 Download PDF

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KR101240464B1
KR101240464B1 KR1020067015208A KR20067015208A KR101240464B1 KR 101240464 B1 KR101240464 B1 KR 101240464B1 KR 1020067015208 A KR1020067015208 A KR 1020067015208A KR 20067015208 A KR20067015208 A KR 20067015208A KR 101240464 B1 KR101240464 B1 KR 101240464B1
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South Korea
Prior art keywords
amino
chloro
methoxybenzoyl
methoxypiperidin
alkyl
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Korean (ko)
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KR20060128966A (ko
Inventor
이안 어윈
모니카 펠메
사이러스 벡커
커트니 루벤스
파스칼 드루즈갈라
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아메데온, 인코포레이티드
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Assigned to 리넥시온 엘엘씨 reassignment 리넥시온 엘엘씨 권리의 전부이전등록 Assignors: 아메데온, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
KR1020067015208A 2004-01-07 2005-01-07 위장 및 중추 신경계 장애를 치료하기 위한 입체이성체적화합물 및 그 치료방법 Expired - Lifetime KR101240464B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53489204P 2004-01-07 2004-01-07
US60/534,892 2004-01-07
US56093804P 2004-04-09 2004-04-09
US60/560,938 2004-04-09
PCT/US2005/000510 WO2005068461A1 (en) 2004-01-07 2005-01-07 Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders

Publications (2)

Publication Number Publication Date
KR20060128966A KR20060128966A (ko) 2006-12-14
KR101240464B1 true KR101240464B1 (ko) 2013-03-08

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KR1020067015208A Expired - Lifetime KR101240464B1 (ko) 2004-01-07 2005-01-07 위장 및 중추 신경계 장애를 치료하기 위한 입체이성체적화합물 및 그 치료방법

Country Status (19)

Country Link
US (2) US7176218B2 (OSRAM)
EP (2) EP1704146B1 (OSRAM)
JP (2) JP5200288B2 (OSRAM)
KR (1) KR101240464B1 (OSRAM)
CN (1) CN101824033B (OSRAM)
AT (1) ATE464308T1 (OSRAM)
AU (2) AU2005205531B2 (OSRAM)
BR (1) BRPI0506736B1 (OSRAM)
CA (1) CA2551686C (OSRAM)
CY (1) CY1110901T1 (OSRAM)
DE (1) DE602005020580D1 (OSRAM)
DK (2) DK1704146T3 (OSRAM)
ES (2) ES2415830T3 (OSRAM)
IL (1) IL176569A (OSRAM)
MX (1) MXPA06007853A (OSRAM)
NO (1) NO337741B1 (OSRAM)
PT (2) PT1704146E (OSRAM)
RU (1) RU2374244C2 (OSRAM)
WO (1) WO2005068461A1 (OSRAM)

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IL176569A (en) 2011-06-30
NO337741B1 (no) 2016-06-13
AU2008243243B2 (en) 2011-03-10
CN101824033B (zh) 2013-02-27
WO2005068461A1 (en) 2005-07-28
RU2006128589A (ru) 2008-02-20
RU2374244C2 (ru) 2009-11-27
BRPI0506736B1 (pt) 2018-08-21
EP2194053B1 (en) 2013-03-27
JP2007517891A (ja) 2007-07-05
EP2194053A1 (en) 2010-06-09
EP1704146B1 (en) 2010-04-14
ES2415830T3 (es) 2013-07-29
PT2194053E (pt) 2013-07-08
AU2005205531A1 (en) 2005-07-28
US7176218B2 (en) 2007-02-13
US20050197363A1 (en) 2005-09-08
AU2008243243A1 (en) 2008-12-04
EP1704146A1 (en) 2006-09-27
CA2551686A1 (en) 2005-07-28
ATE464308T1 (de) 2010-04-15
KR20060128966A (ko) 2006-12-14
DE602005020580D1 (de) 2010-05-27
DK1704146T3 (da) 2010-06-28
CN101824033A (zh) 2010-09-08
BRPI0506736B8 (OSRAM) 2021-05-25
CY1110901T1 (el) 2015-06-10
PT1704146E (pt) 2010-06-30
BRPI0506736A (pt) 2007-05-15
JP5524939B2 (ja) 2014-06-18
JP2012102102A (ja) 2012-05-31
CA2551686C (en) 2014-09-23
AU2005205531B2 (en) 2011-03-17
JP5200288B2 (ja) 2013-06-05
MXPA06007853A (es) 2007-01-26
US20050176757A1 (en) 2005-08-11
DK2194053T3 (da) 2013-07-01
IL176569A0 (en) 2006-10-31
NO20063568L (no) 2006-08-07
ES2344568T3 (es) 2010-08-31
US7282509B2 (en) 2007-10-16

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