KR101235497B1 - 신규 화합물 - Google Patents

신규 화합물 Download PDF

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Publication number
KR101235497B1
KR101235497B1 KR1020077021881A KR20077021881A KR101235497B1 KR 101235497 B1 KR101235497 B1 KR 101235497B1 KR 1020077021881 A KR1020077021881 A KR 1020077021881A KR 20077021881 A KR20077021881 A KR 20077021881A KR 101235497 B1 KR101235497 B1 KR 101235497B1
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KR
South Korea
Prior art keywords
alkyl
heteroaryl
aryl
cycloalkyl
hydrogen
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Expired - Fee Related
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KR1020077021881A
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English (en)
Korean (ko)
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KR20070113255A (ko
Inventor
제임스 프란시스 칼라한
제프리 씨. 보엠
안토니 윌리암 제임스 쿠퍼
스테파노 리비아
네이사 네빈스
제홍 완
베쓰 에이. 노르톤
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글락소 그룹 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
KR1020077021881A 2005-03-25 2006-03-24 신규 화합물 Expired - Fee Related KR101235497B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66531505P 2005-03-25 2005-03-25
US60/665,315 2005-03-25
PCT/US2006/010855 WO2006104915A2 (en) 2005-03-25 2006-03-24 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS

Publications (2)

Publication Number Publication Date
KR20070113255A KR20070113255A (ko) 2007-11-28
KR101235497B1 true KR101235497B1 (ko) 2013-02-20

Family

ID=37053943

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077021881A Expired - Fee Related KR101235497B1 (ko) 2005-03-25 2006-03-24 신규 화합물

Country Status (24)

Country Link
US (3) US8207176B2 (enrdf_load_stackoverflow)
EP (3) EP1868611B1 (enrdf_load_stackoverflow)
JP (1) JP5037487B2 (enrdf_load_stackoverflow)
KR (1) KR101235497B1 (enrdf_load_stackoverflow)
CN (4) CN102746301A (enrdf_load_stackoverflow)
AR (1) AR053346A1 (enrdf_load_stackoverflow)
AU (1) AU2006229993B2 (enrdf_load_stackoverflow)
BR (1) BRPI0609437A2 (enrdf_load_stackoverflow)
CA (1) CA2602553C (enrdf_load_stackoverflow)
EA (1) EA012875B1 (enrdf_load_stackoverflow)
ES (2) ES2398246T3 (enrdf_load_stackoverflow)
IL (1) IL185870A (enrdf_load_stackoverflow)
MA (1) MA29341B1 (enrdf_load_stackoverflow)
MX (1) MX2007011856A (enrdf_load_stackoverflow)
MY (2) MY145281A (enrdf_load_stackoverflow)
NO (1) NO20075275L (enrdf_load_stackoverflow)
NZ (1) NZ561237A (enrdf_load_stackoverflow)
PE (2) PE20100737A1 (enrdf_load_stackoverflow)
SG (1) SG166771A1 (enrdf_load_stackoverflow)
TW (1) TWI389690B (enrdf_load_stackoverflow)
UA (1) UA95444C2 (enrdf_load_stackoverflow)
UY (1) UY29440A1 (enrdf_load_stackoverflow)
WO (1) WO2006104915A2 (enrdf_load_stackoverflow)
ZA (1) ZA200707564B (enrdf_load_stackoverflow)

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DK1333833T3 (da) * 2000-10-23 2011-12-12 Glaxosmithkline Llc Ny trisubstitueret 8H-pyridol[2,3-d]pyrimidin-7-on-forbindelse til behandling af CSBP/RK/p38-kinnasemedierede sygdomme
AU2003225072A1 (en) * 2002-04-19 2003-11-03 Smithkline Beecham Corporation Novel compounds
TWI389690B (zh) 2005-03-25 2013-03-21 Glaxo Group Ltd 新穎化合物（一）
WO2006110298A2 (en) * 2005-03-25 2006-10-19 Glaxo Group Limited 8-alkyl/aryl-4-aryl-2-n- (alkylamino)-n'-substituted-n'-cyanoguanidino-8h-pyrido[2,3-d]pyrimidin-7-one compounds and use thereof
PE20061193A1 (es) * 2005-03-25 2006-12-02 Glaxo Group Ltd DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
CA2603163A1 (en) * 2005-03-25 2006-10-05 Glaxo Group Limited Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives
EP2034838A4 (en) * 2006-06-16 2012-01-04 Glaxo Group Ltd NOVEL CONNECTIONS
EP2032142A4 (en) * 2006-06-16 2010-07-21 Glaxo Group Ltd NOVEL CONNECTIONS
GB0621830D0 (en) * 2006-11-02 2006-12-13 Chroma Therapeutics Ltd Inhibitors of p38 mitogen-activated protein kinase
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
EP2748147B1 (en) * 2011-08-25 2017-08-02 St. Jude Children's Research Hospital Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides for antimalarial therapies
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
SG11202003035SA (en) 2017-10-05 2020-04-29 Fulcrum Therapeutics Inc Use of p38 inhibitors to reduce expression of dux4

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JP2004517922A (ja) 2000-10-23 2004-06-17 スミスクライン・ビーチャム・コーポレイション 新規化合物

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