KR101207736B1 - 신규한 피론-인돌 유도체들 및 그 제조 공정 - Google Patents

신규한 피론-인돌 유도체들 및 그 제조 공정 Download PDF

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KR101207736B1
KR101207736B1 KR1020087022304A KR20087022304A KR101207736B1 KR 101207736 B1 KR101207736 B1 KR 101207736B1 KR 1020087022304 A KR1020087022304 A KR 1020087022304A KR 20087022304 A KR20087022304 A KR 20087022304A KR 101207736 B1 KR101207736 B1 KR 101207736B1
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ring
methoxy
disorders
pyron
formulation
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KR20080094945A (ko
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모쉬 라우돈
탈 페레그-슐만
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뉴림 파머슈티칼스 (1991) 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
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  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
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  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
KR1020087022304A 2006-02-15 2007-02-13 신규한 피론-인돌 유도체들 및 그 제조 공정 Active KR101207736B1 (ko)

Applications Claiming Priority (2)

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US77332206P 2006-02-15 2006-02-15
US60/773,322 2006-02-15

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KR20080094945A KR20080094945A (ko) 2008-10-27
KR101207736B1 true KR101207736B1 (ko) 2012-12-03

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Country Status (21)

Country Link
US (3) US7635710B2 (https=)
EP (1) EP1991541B1 (https=)
JP (1) JP5248332B2 (https=)
KR (1) KR101207736B1 (https=)
CN (1) CN101374833B (https=)
AU (1) AU2007216226B2 (https=)
BR (1) BRPI0706992C8 (https=)
CA (1) CA2642465C (https=)
DK (1) DK1991541T3 (https=)
EA (1) EA015605B1 (https=)
ES (1) ES2428873T3 (https=)
IL (1) IL193236A (https=)
NO (1) NO339826B1 (https=)
NZ (1) NZ569797A (https=)
PL (1) PL1991541T3 (https=)
PT (1) PT1991541E (https=)
SI (1) SI1991541T1 (https=)
TW (1) TWI501960B (https=)
UA (1) UA104988C2 (https=)
WO (1) WO2007093880A2 (https=)
ZA (1) ZA200806799B (https=)

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US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
KR20160100998A (ko) * 2014-01-14 2016-08-24 아스테라스 세이야쿠 가부시키가이샤 인돌 화합물
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
CN113546174A (zh) 2015-02-25 2021-10-26 加利福尼亚大学董事会 用于治疗病症的5ht激动剂
JP6910424B2 (ja) * 2016-08-23 2021-07-28 ニューリム・ファーマシューティカルズ・リミテッドＮｅｕｒｉｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 掻痒症および／または痒みの治療方法
JP2020529440A (ja) 2017-08-04 2020-10-08 オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 糖尿病および関連する状態の処置におけるガボキサドールの使用
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
MX2021003302A (es) 2018-09-20 2021-05-13 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez.
EP3880201A4 (en) 2018-12-17 2022-07-27 Ovid Therapeutics Inc. USE OF GABOXADOL IN THE TREATMENT OF NON-24 HOUR SLEEP waking disorder
WO2021229566A1 (en) * 2020-05-11 2021-11-18 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions of tryptophol derivatives and 4-ethyl-phenol derivatives, and methods of using same
BR112023023501A2 (pt) 2021-05-11 2024-02-27 Neurim Pharmaceuticals 1991 Ltd Método para diagnóstico e tratamento de indivíduos com polimorfismos de nucleotídeos únicos no cromossomo 2, locus 2:107.510.000107.540.000
TW202444347A (zh) 2023-01-13 2024-11-16 以色列商琉璃藥品（１９９１）有限公司 使用吡美拉汀(piromelatine)治療與rem睡眠鬆弛喪失相關之異睡症之方法

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EP0272228A2 (en) 1986-02-16 1988-06-22 Rotta Research Laboratorium S.P.A. New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation
WO1992007829A1 (en) 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2006002125A1 (en) 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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Patent Citations (3)

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EP0272228A2 (en) 1986-02-16 1988-06-22 Rotta Research Laboratorium S.P.A. New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation
WO1992007829A1 (en) 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2006002125A1 (en) 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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ZA200806799B (en) 2009-10-28
US20100048662A1 (en) 2010-02-25
EA015605B1 (ru) 2011-10-31
JP2009526831A (ja) 2009-07-23
PL1991541T3 (pl) 2013-12-31
ES2428873T3 (es) 2013-11-12
US20080027121A1 (en) 2008-01-31
CN101374833B (zh) 2012-06-27
CA2642465C (en) 2012-08-07
CA2642465A1 (en) 2007-08-23
CN101374833A (zh) 2009-02-25
KR20080094945A (ko) 2008-10-27
NZ569797A (en) 2010-06-25
IL193236A0 (en) 2009-02-11
HK1126760A1 (en) 2009-09-11
AU2007216226A2 (en) 2009-05-14
EP1991541A2 (en) 2008-11-19
WO2007093880A2 (en) 2007-08-23
BRPI0706992B1 (pt) 2021-05-04
US20120302620A1 (en) 2012-11-29
NO339826B1 (no) 2017-02-06
DK1991541T3 (da) 2013-10-28
JP5248332B2 (ja) 2013-07-31
NO20083905L (no) 2008-09-12
US7635710B2 (en) 2009-12-22
TW200835690A (en) 2008-09-01
PT1991541E (pt) 2013-10-02
EP1991541B1 (en) 2013-07-24
BRPI0706992A2 (pt) 2011-04-12
US8242163B2 (en) 2012-08-14
IL193236A (en) 2012-08-30
EA200801580A1 (ru) 2009-02-27
AU2007216226A1 (en) 2007-08-23
US8569355B2 (en) 2013-10-29
BRPI0706992C1 (pt) 2021-05-18
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
BRPI0706992C8 (pt) 2021-05-25
WO2007093880A3 (en) 2007-11-01
AU2007216226B2 (en) 2011-02-24
TWI501960B (zh) 2015-10-01

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