CN101374833B - 新型吡喃酮-吲哚衍生物及其制备方法 - Google Patents

新型吡喃酮-吲哚衍生物及其制备方法 Download PDF

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CN101374833B
CN101374833B CN2007800039654A CN200780003965A CN101374833B CN 101374833 B CN101374833 B CN 101374833B CN 2007800039654 A CN2007800039654 A CN 2007800039654A CN 200780003965 A CN200780003965 A CN 200780003965A CN 101374833 B CN101374833 B CN 101374833B
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ring
preparation
pyrone
salt
disease
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CN101374833A (zh
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莫什·劳顿
塔尔·派莱格舒尔曼
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Neurim Pharmaceuticals 1991 Ltd
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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CN2007800039654A 2006-02-15 2007-02-13 新型吡喃酮-吲哚衍生物及其制备方法 Active CN101374833B (zh)

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US77332206P 2006-02-15 2006-02-15
US60/773,322 2006-02-15
PCT/IB2007/000330 WO2007093880A2 (en) 2006-02-15 2007-02-13 Novel pyrone-indole derivatives and process for their preparation

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US (3) US7635710B2 (https=)
EP (1) EP1991541B1 (https=)
JP (1) JP5248332B2 (https=)
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KR20160100998A (ko) * 2014-01-14 2016-08-24 아스테라스 세이야쿠 가부시키가이샤 인돌 화합물
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US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
CN113546174A (zh) 2015-02-25 2021-10-26 加利福尼亚大学董事会 用于治疗病症的5ht激动剂
JP6910424B2 (ja) * 2016-08-23 2021-07-28 ニューリム・ファーマシューティカルズ・リミテッドＮｅｕｒｉｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 掻痒症および／または痒みの治療方法
JP2020529440A (ja) 2017-08-04 2020-10-08 オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 糖尿病および関連する状態の処置におけるガボキサドールの使用
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
MX2021003302A (es) 2018-09-20 2021-05-13 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez.
EP3880201A4 (en) 2018-12-17 2022-07-27 Ovid Therapeutics Inc. USE OF GABOXADOL IN THE TREATMENT OF NON-24 HOUR SLEEP waking disorder
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BR112023023501A2 (pt) 2021-05-11 2024-02-27 Neurim Pharmaceuticals 1991 Ltd Método para diagnóstico e tratamento de indivíduos com polimorfismos de nucleotídeos únicos no cromossomo 2, locus 2:107.510.000107.540.000
TW202444347A (zh) 2023-01-13 2024-11-16 以色列商琉璃藥品（１９９１）有限公司 使用吡美拉汀(piromelatine)治療與rem睡眠鬆弛喪失相關之異睡症之方法

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US20100048662A1 (en) 2010-02-25
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PL1991541T3 (pl) 2013-12-31
ES2428873T3 (es) 2013-11-12
US20080027121A1 (en) 2008-01-31
CA2642465C (en) 2012-08-07
CA2642465A1 (en) 2007-08-23
CN101374833A (zh) 2009-02-25
KR20080094945A (ko) 2008-10-27
NZ569797A (en) 2010-06-25
IL193236A0 (en) 2009-02-11
HK1126760A1 (en) 2009-09-11
AU2007216226A2 (en) 2009-05-14
EP1991541A2 (en) 2008-11-19
WO2007093880A2 (en) 2007-08-23
BRPI0706992B1 (pt) 2021-05-04
US20120302620A1 (en) 2012-11-29
KR101207736B1 (ko) 2012-12-03
NO339826B1 (no) 2017-02-06
DK1991541T3 (da) 2013-10-28
JP5248332B2 (ja) 2013-07-31
NO20083905L (no) 2008-09-12
US7635710B2 (en) 2009-12-22
TW200835690A (en) 2008-09-01
PT1991541E (pt) 2013-10-02
EP1991541B1 (en) 2013-07-24
BRPI0706992A2 (pt) 2011-04-12
US8242163B2 (en) 2012-08-14
IL193236A (en) 2012-08-30
EA200801580A1 (ru) 2009-02-27
AU2007216226A1 (en) 2007-08-23
US8569355B2 (en) 2013-10-29
BRPI0706992C1 (pt) 2021-05-18
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
BRPI0706992C8 (pt) 2021-05-25
WO2007093880A3 (en) 2007-11-01
AU2007216226B2 (en) 2011-02-24
TWI501960B (zh) 2015-10-01

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