KR101120936B1 - 티에노피리딘 및 푸로피리딘 키나제 억제제 - Google Patents

티에노피리딘 및 푸로피리딘 키나제 억제제 Download PDF

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KR101120936B1
KR101120936B1 KR1020067001692A KR20067001692A KR101120936B1 KR 101120936 B1 KR101120936 B1 KR 101120936B1 KR 1020067001692 A KR1020067001692 A KR 1020067001692A KR 20067001692 A KR20067001692 A KR 20067001692A KR 101120936 B1 KR101120936 B1 KR 101120936B1
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South Korea
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group
alkyl
aryl
amino
phenyl
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KR1020067001692A
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Korean (ko)
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KR20060056344A (ko
Inventor
파트릭 벳슈만
앤드류 에프. 버챗
데이빗 제이. 캘더우드
마이클 엘. 커틴
스티븐 케이. 데이빗슨
히터 엠. 데이비스
로빈 알. 프레이
하워드 알. 헤이먼
개빈 씨. 허스트
피터 흐른씨아르
마이클 알. 마이클라이즈
멜라니 에이. 먹키
폴 라퍼티
캐롤 케이. 와다
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아보트 러보러터리즈
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Priority claimed from US10/626,092 external-priority patent/US20050020619A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/06—Antianaemics
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    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
KR1020067001692A 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제 Expired - Fee Related KR101120936B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/626,092 2003-07-24
US10/626,092 US20050020619A1 (en) 2003-07-24 2003-07-24 Thienopyridine kinase inhibitors
US10/838,132 2004-05-03
US10/838,132 US20050026944A1 (en) 2003-07-24 2004-05-03 Thienopyridine and furopyridine kinase inhibitors
PCT/US2004/024003 WO2005010009A1 (en) 2003-07-24 2004-07-26 Thienopyridine and furopyridine kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117023338A Division KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Publications (2)

Publication Number Publication Date
KR20060056344A KR20060056344A (ko) 2006-05-24
KR101120936B1 true KR101120936B1 (ko) 2012-03-29

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ID=34108157

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Application Number Title Priority Date Filing Date
KR1020067001692A Expired - Fee Related KR101120936B1 (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제
KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

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KR1020117023338A Withdrawn KR20110123797A (ko) 2003-07-24 2004-07-26 티에노피리딘 및 푸로피리딘 키나제 억제제

Country Status (19)

Country Link
US (1) US20050026944A1 (enExample)
EP (1) EP1648905B1 (enExample)
JP (1) JP4707192B2 (enExample)
KR (2) KR101120936B1 (enExample)
CN (1) CN103087078A (enExample)
AT (1) ATE419253T1 (enExample)
AU (2) AU2004259765B2 (enExample)
BR (1) BRPI0412894A (enExample)
CA (1) CA2532982C (enExample)
CY (1) CY1111599T1 (enExample)
DE (1) DE602004018780D1 (enExample)
DK (1) DK1648905T3 (enExample)
ES (1) ES2319302T3 (enExample)
IL (1) IL173348A (enExample)
MX (1) MXPA06000919A (enExample)
NZ (1) NZ544712A (enExample)
PL (1) PL1648905T3 (enExample)
PT (1) PT1648905E (enExample)
WO (1) WO2005010009A1 (enExample)

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JP2009514899A (ja) * 2005-11-04 2009-04-09 スミスクライン ビーチャム コーポレーション チエノピリジンＢ−Ｒａｆキナーゼ阻害剤
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US7994321B2 (en) * 2006-08-08 2011-08-09 Hoffmann-La Roche Inc. Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives
WO2008018881A1 (en) * 2006-08-10 2008-02-14 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
MX2010001636A (es) * 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
CA2723358A1 (en) * 2008-05-05 2009-11-12 Allison B. Reiss Method for improving cardiovascular risk profile of cox inhibitors
ES2524966T3 (es) * 2008-12-05 2014-12-16 Abbvie Bahamas Ltd. Derivados de tieno[3,2-c]piridina como inhibidores de quinasas para uso en el tratamiento del cáncer
CN102574843B (zh) * 2009-10-22 2015-06-17 法博太科制药有限公司 抗纤维化剂的稠环类似物
WO2011156473A1 (en) * 2010-06-09 2011-12-15 Abbott Laboratories Crystalline forms of kinase inhibitors
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
TWI482770B (zh) * 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
MX2012014487A (es) 2010-07-02 2013-02-21 Alcon Res Ltd Compuestos para el tratamiento de transtornos y enfermedades del segmento posterior.
SG189837A1 (en) * 2010-10-08 2013-06-28 Abbvie Inc FURO[3,2-d]PYRIMIDINE COMPOUNDS
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
CN103396414B (zh) * 2013-07-16 2015-06-03 浙江医药高等专科学校 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途
CN104945411B (zh) * 2014-03-27 2018-07-31 南京勇山生物科技有限公司 噻吩并[3,2-c]吡啶类化合物、其制备方法及应用
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AU2009251083A1 (en) 2010-01-21
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IL173348A (en) 2015-11-30
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US20050026944A1 (en) 2005-02-03
AU2004259765B2 (en) 2009-10-22
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