CY1111599T1 - Αναστολεις κινασης θειενοπυριδινης και φουροπυριδινης - Google Patents
Αναστολεις κινασης θειενοπυριδινης και φουροπυριδινηςInfo
- Publication number
- CY1111599T1 CY1111599T1 CY20091100278T CY091100278T CY1111599T1 CY 1111599 T1 CY1111599 T1 CY 1111599T1 CY 20091100278 T CY20091100278 T CY 20091100278T CY 091100278 T CY091100278 T CY 091100278T CY 1111599 T1 CY1111599 T1 CY 1111599T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fouropyridine
- thienopyridine
- compounds
- kinase inhibitions
- inhibitions
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title 1
- 229940125670 thienopyridine Drugs 0.000 title 1
- 239000002175 thienopyridine Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/626,092 US20050020619A1 (en) | 2003-07-24 | 2003-07-24 | Thienopyridine kinase inhibitors |
| US10/838,132 US20050026944A1 (en) | 2003-07-24 | 2004-05-03 | Thienopyridine and furopyridine kinase inhibitors |
| EP04779180A EP1648905B1 (en) | 2003-07-24 | 2004-07-26 | Thienopyridine and furopyridine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111599T1 true CY1111599T1 (el) | 2015-10-07 |
Family
ID=34108157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100278T CY1111599T1 (el) | 2003-07-24 | 2009-03-12 | Αναστολεις κινασης θειενοπυριδινης και φουροπυριδινης |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050026944A1 (enExample) |
| EP (1) | EP1648905B1 (enExample) |
| JP (1) | JP4707192B2 (enExample) |
| KR (2) | KR101120936B1 (enExample) |
| CN (1) | CN103087078A (enExample) |
| AT (1) | ATE419253T1 (enExample) |
| AU (2) | AU2004259765B2 (enExample) |
| BR (1) | BRPI0412894A (enExample) |
| CA (1) | CA2532982C (enExample) |
| CY (1) | CY1111599T1 (enExample) |
| DE (1) | DE602004018780D1 (enExample) |
| DK (1) | DK1648905T3 (enExample) |
| ES (1) | ES2319302T3 (enExample) |
| IL (1) | IL173348A (enExample) |
| MX (1) | MXPA06000919A (enExample) |
| NZ (1) | NZ544712A (enExample) |
| PL (1) | PL1648905T3 (enExample) |
| PT (1) | PT1648905E (enExample) |
| WO (1) | WO2005010009A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006528685A (ja) * | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
| US7899855B2 (en) * | 2003-09-08 | 2011-03-01 | Intel Corporation | Method, apparatus and instructions for parallel data conversions |
| GB0325836D0 (en) * | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
| TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US20050256154A1 (en) * | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| US7566721B2 (en) * | 2005-08-08 | 2009-07-28 | Osi Pharmaceuticals, Inc. | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors |
| BRPI0520482A2 (pt) * | 2005-08-16 | 2009-05-12 | Hoffmann La Roche | amidas do ácido 4-amino-tieno [3,2-c] piridina-7-carboxìlico |
| AU2006290802B2 (en) * | 2005-09-15 | 2012-06-07 | F. Hoffmann-La Roche Ag | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives |
| JP2009514899A (ja) * | 2005-11-04 | 2009-04-09 | スミスクライン ビーチャム コーポレーション | チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 |
| EP1968979A2 (en) * | 2005-12-08 | 2008-09-17 | Abbott Laboratories | 9-membered heterobicyclic compounds as inhibitors of protein kinases |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| TW201307354A (zh) * | 2005-12-29 | 2013-02-16 | Abbott Lab | 蛋白質激酶抑制劑 |
| AU2007215161A1 (en) * | 2006-02-14 | 2007-08-23 | Vertex Pharmaceuticals Incorporated | Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases |
| US7932390B2 (en) * | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
| US7994321B2 (en) * | 2006-08-08 | 2011-08-09 | Hoffmann-La Roche Inc. | Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives |
| WO2008018881A1 (en) * | 2006-08-10 | 2008-02-14 | Osi Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors |
| MX2010001636A (es) * | 2007-08-14 | 2010-03-15 | Hoffmann La Roche | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
| AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
| CA2723358A1 (en) * | 2008-05-05 | 2009-11-12 | Allison B. Reiss | Method for improving cardiovascular risk profile of cox inhibitors |
| ES2524966T3 (es) * | 2008-12-05 | 2014-12-16 | Abbvie Bahamas Ltd. | Derivados de tieno[3,2-c]piridina como inhibidores de quinasas para uso en el tratamiento del cáncer |
| CN102574843B (zh) * | 2009-10-22 | 2015-06-17 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| WO2011156473A1 (en) * | 2010-06-09 | 2011-12-15 | Abbott Laboratories | Crystalline forms of kinase inhibitors |
| TWI492949B (zh) * | 2010-06-09 | 2015-07-21 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| TWI482770B (zh) * | 2010-06-09 | 2015-05-01 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| MX2012014487A (es) | 2010-07-02 | 2013-02-21 | Alcon Res Ltd | Compuestos para el tratamiento de transtornos y enfermedades del segmento posterior. |
| SG189837A1 (en) * | 2010-10-08 | 2013-06-28 | Abbvie Inc | FURO[3,2-d]PYRIMIDINE COMPOUNDS |
| US8436179B2 (en) | 2011-07-20 | 2013-05-07 | Abbvie Inc. | Kinase inhibitor with improved solubility profile |
| CN103396414B (zh) * | 2013-07-16 | 2015-06-03 | 浙江医药高等专科学校 | 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途 |
| CN104945411B (zh) * | 2014-03-27 | 2018-07-31 | 南京勇山生物科技有限公司 | 噻吩并[3,2-c]吡啶类化合物、其制备方法及应用 |
| WO2015157360A1 (en) | 2014-04-08 | 2015-10-15 | Abbvie Inc. | Processes to make protein kinase inhibitors |
| WO2016047678A1 (ja) * | 2014-09-25 | 2016-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2019009235A (es) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd | Compuestos antifibroticos. |
| JP2023549540A (ja) | 2020-11-18 | 2023-11-27 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1025102B1 (en) * | 1997-10-20 | 2004-05-19 | F. Hoffmann-La Roche Ag | Bicyclic kinase inhibitors |
| CA2320730A1 (en) * | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
| NZ517759A (en) * | 1999-09-17 | 2004-04-30 | Abbott Gmbh & Co | Kinase inhibitors as therapeutic agents |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| KR100774855B1 (ko) * | 2000-04-27 | 2007-11-08 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 헤테로아릴 유도체 |
| EP1373240B1 (en) * | 2001-03-14 | 2005-06-15 | Eli Lilly And Company | Retinoid x receptor modulators |
| JP2005508904A (ja) * | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| JP2006528685A (ja) * | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
-
2004
- 2004-05-03 US US10/838,132 patent/US20050026944A1/en not_active Abandoned
- 2004-07-26 KR KR1020067001692A patent/KR101120936B1/ko not_active Expired - Fee Related
- 2004-07-26 DE DE602004018780T patent/DE602004018780D1/de not_active Expired - Lifetime
- 2004-07-26 PL PL04779180T patent/PL1648905T3/pl unknown
- 2004-07-26 EP EP04779180A patent/EP1648905B1/en not_active Expired - Lifetime
- 2004-07-26 CA CA2532982A patent/CA2532982C/en not_active Expired - Fee Related
- 2004-07-26 CN CN2012105340956A patent/CN103087078A/zh active Pending
- 2004-07-26 NZ NZ544712A patent/NZ544712A/en not_active IP Right Cessation
- 2004-07-26 ES ES04779180T patent/ES2319302T3/es not_active Expired - Lifetime
- 2004-07-26 WO PCT/US2004/024003 patent/WO2005010009A1/en not_active Ceased
- 2004-07-26 JP JP2006521305A patent/JP4707192B2/ja not_active Expired - Fee Related
- 2004-07-26 AU AU2004259765A patent/AU2004259765B2/en not_active Ceased
- 2004-07-26 MX MXPA06000919A patent/MXPA06000919A/es active IP Right Grant
- 2004-07-26 DK DK04779180T patent/DK1648905T3/da active
- 2004-07-26 AT AT04779180T patent/ATE419253T1/de active
- 2004-07-26 PT PT04779180T patent/PT1648905E/pt unknown
- 2004-07-26 BR BRPI0412894-0A patent/BRPI0412894A/pt not_active IP Right Cessation
- 2004-07-26 KR KR1020117023338A patent/KR20110123797A/ko not_active Withdrawn
-
2006
- 2006-01-24 IL IL173348A patent/IL173348A/en not_active IP Right Cessation
-
2009
- 2009-03-12 CY CY20091100278T patent/CY1111599T1/el unknown
- 2009-12-22 AU AU2009251083A patent/AU2009251083B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004018780D1 (de) | 2009-02-12 |
| CN103087078A (zh) | 2013-05-08 |
| CA2532982C (en) | 2013-11-26 |
| AU2004259765A1 (en) | 2005-02-03 |
| ATE419253T1 (de) | 2009-01-15 |
| AU2009251083A1 (en) | 2010-01-21 |
| KR101120936B1 (ko) | 2012-03-29 |
| PL1648905T3 (pl) | 2009-07-31 |
| JP2006528646A (ja) | 2006-12-21 |
| IL173348A (en) | 2015-11-30 |
| WO2005010009A1 (en) | 2005-02-03 |
| KR20060056344A (ko) | 2006-05-24 |
| PT1648905E (pt) | 2009-04-08 |
| CA2532982A1 (en) | 2005-02-03 |
| US20050026944A1 (en) | 2005-02-03 |
| AU2004259765B2 (en) | 2009-10-22 |
| JP4707192B2 (ja) | 2011-06-22 |
| BRPI0412894A (pt) | 2006-10-03 |
| EP1648905A1 (en) | 2006-04-26 |
| NZ544712A (en) | 2009-09-25 |
| AU2009251083B2 (en) | 2012-02-16 |
| EP1648905B1 (en) | 2008-12-31 |
| DK1648905T3 (da) | 2009-03-30 |
| IL173348A0 (en) | 2006-06-11 |
| ES2319302T3 (es) | 2009-05-06 |
| KR20110123797A (ko) | 2011-11-15 |
| MXPA06000919A (es) | 2006-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1111599T1 (el) | Αναστολεις κινασης θειενοπυριδινης και φουροπυριδινης | |
| BR0215360A (pt) | Derivados de indolina úteis como inibidores de proteìna quinase | |
| DK1347971T3 (da) | Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien | |
| ATE554087T1 (de) | Neue kinaseinhibitoren | |
| ATE469888T1 (de) | Indazol-, benzisoxazol- und benzisothiazol- kinaseinhibitoren | |
| CY1109681T1 (el) | Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων aurora | |
| BR0313176A (pt) | Composições de pirazol úteis como inibidores de gsk-3 | |
| BRPI0508220A (pt) | derivados de pirazol heteroarila fundidos | |
| CY1110914T1 (el) | Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν | |
| CY1110225T1 (el) | Κυκλικοι αναστολεις πρωτεϊνικης τυροσινικης κινασης | |
| PL406680A1 (pl) | Inhibitory kinaz tyrozynowych | |
| MXPA05013076A (es) | Compuestos de isoindolina-1-ona como inhibidores de cinasa. | |
| MEP20908A (en) | Thienopyrazoles | |
| BRPI0407841A (pt) | inibidores heterocìclicos de quinase | |
| IL153680A0 (en) | Aplidine derivatives and methods for the preparation thereof | |
| BR0308606A (pt) | Derivados de hemiasterlina e usos destes | |
| DK1606288T3 (da) | Benzensulfonamidderivater, fremgangsmåde til fremstilling deraf og deres anvendelse til behandling af smerte | |
| MXPA04005809A (es) | Inhibidores de proteinas quinasas. | |
| SE0100374D0 (sv) | Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof | |
| WO2003080624A3 (en) | Dithiolopyrrolone derivatives useful in the treatment of proliferative diseases |