KR101119878B1 - 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 - Google Patents

프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 Download PDF

Info

Publication number
KR101119878B1
KR101119878B1 KR1020047014503A KR20047014503A KR101119878B1 KR 101119878 B1 KR101119878 B1 KR 101119878B1 KR 1020047014503 A KR1020047014503 A KR 1020047014503A KR 20047014503 A KR20047014503 A KR 20047014503A KR 101119878 B1 KR101119878 B1 KR 101119878B1
Authority
KR
South Korea
Prior art keywords
cells
stem cells
liver
delete delete
primitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047014503A
Other languages
English (en)
Korean (ko)
Other versions
KR20060010693A (ko
Inventor
레이드롤라
모스니콜라스지.
퍼스마크이.
루드로우존더블유.
브루스앤드류티.
Original Assignee
베스타 테라퓨틱스 인코포레이티드
유니버시티 오브 노스캐롤라이나 앳 채플 힐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베스타 테라퓨틱스 인코포레이티드, 유니버시티 오브 노스캐롤라이나 앳 채플 힐 filed Critical 베스타 테라퓨틱스 인코포레이티드
Publication of KR20060010693A publication Critical patent/KR20060010693A/ko
Application granted granted Critical
Publication of KR101119878B1 publication Critical patent/KR101119878B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/24Iron; Fe chelators; Transferrin
    • C12N2500/25Insulin-transferrin; Insulin-transferrin-selenium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/36Lipids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525ICAM molecules, e.g. CD50, CD54, CD102
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020047014503A 2002-03-15 2003-03-14 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포 Expired - Fee Related KR101119878B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15

Publications (2)

Publication Number Publication Date
KR20060010693A KR20060010693A (ko) 2006-02-02
KR101119878B1 true KR101119878B1 (ko) 2012-03-09

Family

ID=28042021

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047014503A Expired - Fee Related KR101119878B1 (ko) 2002-03-15 2003-03-14 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포

Country Status (18)

Country Link
US (4) US7413897B2 (https=)
EP (2) EP3023491A1 (https=)
JP (2) JP4723811B2 (https=)
KR (1) KR101119878B1 (https=)
CN (3) CN1742082B (https=)
AU (2) AU2003233399B2 (https=)
CA (1) CA2479510C (https=)
CY (1) CY1118167T1 (https=)
DK (1) DK1490480T3 (https=)
ES (1) ES2569951T3 (https=)
HK (1) HK1209783A1 (https=)
HU (1) HUE032238T2 (https=)
IL (1) IL164048A0 (https=)
MX (1) MXPA04009031A (https=)
PL (1) PL372619A1 (https=)
RU (1) RU2327479C2 (https=)
SI (1) SI1490480T1 (https=)
WO (1) WO2003078588A2 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue)
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
AU2006315163A1 (en) 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
US20070148141A1 (en) * 2005-12-22 2007-06-28 Vesta Therapeutics Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
EP2019859A4 (en) * 2006-04-25 2009-11-25 Univ Louisiana State ADULT FAMILY CELLS FROM FAT TISSUE FOR LIVER REGENERATION
ES2664375T3 (es) 2006-05-26 2018-04-19 The University Of North Carolina At Chapel Hill Precursores de células estrelladas hepáticas y métodos para aislarlos
CA2727535A1 (en) * 2007-06-15 2008-12-24 University Of North Carolina At Chapel Hill Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
WO2009139419A1 (ja) * 2008-05-14 2009-11-19 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
CA2724839A1 (en) * 2008-05-21 2009-11-26 Bioe Llc Differentiation of multi-lineage progenitor cells to pancreatic cells
ES2862623T3 (es) 2008-05-22 2021-10-07 Vesta Therapeutics Inc Método de diferenciación de células progenitoras de mamíferos en células pancreáticas de los islotes productoras de insulina
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
CN105456292B (zh) * 2009-10-30 2019-03-26 北卡罗来纳大学教堂山分校 来自肝外胆管树的专能干细胞及其分离方法
JP5943521B2 (ja) * 2010-11-19 2016-07-05 株式会社オンチップ・バイオテクノロジーズ 高濃度夾雑細胞群から低濃度の特定細胞を検出する方法と検出した細胞を回収し解析する方法
KR102034496B1 (ko) * 2011-05-27 2019-10-22 디퍼이 신테스 프로덕츠, 인코포레이티드 인공 근위세뇨관 시스템 및 사용 방법
PT2788009T (pt) 2011-12-08 2016-08-31 Yeda Res & Dev Células pulmonares fetais de mamíferos e uso terapêutico das mesmas
CN104508122A (zh) * 2012-06-20 2015-04-08 赛璐拉有限公司 用于处理细胞群体的材料和方法
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG11201707615YA (en) * 2013-09-19 2017-10-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
JP6643993B2 (ja) 2013-12-16 2020-02-12 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 膵島様細胞構造体及びそれを調製する方法
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
WO2016200340A1 (en) 2015-06-12 2016-12-15 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof
EP4026563B1 (en) 2015-06-18 2025-10-29 Yeda Research and Development Co. Ltd Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3743080A4 (en) * 2018-01-26 2021-10-27 Polarityte, Inc. SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
WO1993003142A1 (en) 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors
ES2260759T3 (es) * 1993-11-19 2006-11-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hepatoblastos y metodo de aislamiento de los mismos.
YU8395A (sh) * 1994-02-14 1998-07-10 Kirin Brewery Company Protein sa tpo aktivnošću
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
CN1305387A (zh) * 1998-04-17 2001-07-25 利思进药品公司 通过共同给予前列腺素抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
PE20001250A1 (es) * 1998-11-16 2000-11-21 Detroit Diesel Corp Metodo y sistema para el control de material devuelto
JP2000287680A (ja) * 1999-04-09 2000-10-17 Sentan Kagaku Gijutsu Incubation Center:Kk 未成熟肝細胞を成熟肝細胞へ分化させる方法
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
CN1461341A (zh) * 2000-10-03 2003-12-10 北卡罗来纳大学 肝祖先细胞克隆生长的方法
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells

Also Published As

Publication number Publication date
EP1490480A4 (en) 2006-06-14
JP2011087591A (ja) 2011-05-06
EP1490480A2 (en) 2004-12-29
JP2005520513A (ja) 2005-07-14
CA2479510A1 (en) 2003-09-25
US20140302601A1 (en) 2014-10-09
JP4723811B2 (ja) 2011-07-13
IL164048A0 (en) 2005-12-18
PL372619A1 (en) 2005-07-25
AU2008202656B8 (en) 2011-12-15
CN1742082A (zh) 2006-03-01
CA2479510C (en) 2019-10-29
WO2003078588A3 (en) 2004-04-01
HK1209783A1 (en) 2016-04-08
AU2008202656A8 (en) 2011-12-15
MXPA04009031A (es) 2005-12-12
CN1742082B (zh) 2015-01-21
DK1490480T3 (en) 2016-04-11
EP3023491A1 (en) 2016-05-25
AU2003233399A1 (en) 2003-09-29
AU2008202656B2 (en) 2011-03-17
ES2569951T3 (es) 2016-05-13
AU2003233399B2 (en) 2008-03-20
RU2327479C2 (ru) 2008-06-27
KR20060010693A (ko) 2006-02-02
US20170096641A1 (en) 2017-04-06
US20040018621A1 (en) 2004-01-29
CN104630129A (zh) 2015-05-20
AU2008202656A1 (en) 2008-07-10
SI1490480T1 (sl) 2016-06-30
WO2003078588A2 (en) 2003-09-25
CY1118167T1 (el) 2017-06-28
HUE032238T2 (en) 2017-09-28
US20070099297A1 (en) 2007-05-03
JP5463271B2 (ja) 2014-04-09
WO2003078588A9 (en) 2003-12-11
US8691523B2 (en) 2014-04-08
US7413897B2 (en) 2008-08-19
EP1490480B1 (en) 2016-02-03
RU2005125598A (ru) 2006-01-27

Similar Documents

Publication Publication Date Title
KR101119878B1 (ko) 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포
US6242252B1 (en) Hepatic progenitors and method of isolating same
KR101195838B1 (ko) 분리된 전분화능 성체줄기세포 및 그의 분리 및 배양 방법
CN1351656B (zh) 人肝脏祖先
JP2013039128A (ja) 幹細胞
KR102218549B1 (ko) 인간 타액선 세포의 배양 방법
HK1225070A1 (en) Primitive and proximal hepatic stem cells
HK1225070A (en) Primitive and proximal hepatic stem cells
Najimi et al. Research Article Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation
HK1176641B (en) Human liver progenitors
IL139319A (en) Isolated hepatocyte precursors, cell cultures containing the same, and compositions containing said cell cultures

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R19-X000 Request for party data change rejected

St.27 status event code: A-3-3-R10-R19-oth-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20150209

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20160119

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20180219

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20190129

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210218

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210218