KR101072339B1 - 프로스타시클린 유사체의 전달을 위한 화합물 및 방법 - Google Patents
프로스타시클린 유사체의 전달을 위한 화합물 및 방법 Download PDFInfo
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- KR101072339B1 KR101072339B1 KR1020057022319A KR20057022319A KR101072339B1 KR 101072339 B1 KR101072339 B1 KR 101072339B1 KR 1020057022319 A KR1020057022319 A KR 1020057022319A KR 20057022319 A KR20057022319 A KR 20057022319A KR 101072339 B1 KR101072339 B1 KR 101072339B1
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- Prior art keywords
- treprostinil
- group
- substituted
- compound
- oral
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- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
- C07C59/13—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
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- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
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- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
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- Physiology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
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- Biomedical Technology (AREA)
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- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47240703P | 2003-05-22 | 2003-05-22 | |
| US60/472,407 | 2003-05-22 | ||
| PCT/US2004/016401 WO2005007081A2 (en) | 2003-05-22 | 2004-05-24 | Compounds and methods for delivery of prostacyclin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060021862A KR20060021862A (ko) | 2006-03-08 |
| KR101072339B1 true KR101072339B1 (ko) | 2011-10-11 |
Family
ID=34079029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057022319A Expired - Lifetime KR101072339B1 (ko) | 2003-05-22 | 2005-11-22 | 프로스타시클린 유사체의 전달을 위한 화합물 및 방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (19) | US7417070B2 (enExample) |
| EP (2) | EP2792353B1 (enExample) |
| JP (2) | JP5043433B2 (enExample) |
| KR (1) | KR101072339B1 (enExample) |
| CN (4) | CN101265226B (enExample) |
| CA (4) | CA2851309C (enExample) |
| ES (2) | ES2622471T5 (enExample) |
| WO (1) | WO2005007081A2 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10214983A1 (de) * | 2002-04-04 | 2004-04-08 | TransMIT Gesellschaft für Technologietransfer mbH | Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen |
| CN101265226B (zh) | 2003-05-22 | 2013-04-24 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| DE602004022982D1 (de) * | 2003-12-16 | 2009-10-15 | United Therapeutics Corp | Verwendung von treprostinil zur verbesserung der nierenfunktion |
| US20090124697A1 (en) * | 2003-12-16 | 2009-05-14 | United Therapeutics Corporation | Inhalation formulations of treprostinil |
| CA2549724C (en) * | 2003-12-16 | 2014-02-11 | United Therapeutics Corporation | Use of treprostinil to treat and prevent ischemic lesions |
| ATE462427T1 (de) | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| KR20080029962A (ko) * | 2005-06-02 | 2008-04-03 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도 | 프로스타사이클린 유사체의 용도 |
| US8747897B2 (en) * | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| KR101390579B1 (ko) | 2006-05-15 | 2014-05-19 | 유나이티드 세러퓨틱스 코오포레이션 | 정량 흡입기를 사용한 트레프로스티닐 투여 |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| US20090036465A1 (en) * | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| WO2008088617A1 (en) * | 2006-12-04 | 2008-07-24 | Regents Of The University Of Colorado | Treatment of copd |
| EP2120961A1 (en) * | 2007-02-09 | 2009-11-25 | United Therapeutics Corporation | Treprostinil treatment for interstitial lung disease and asthma |
| KR20160048222A (ko) * | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
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- 2015-10-28 US US14/925,084 patent/US9624156B2/en not_active Expired - Fee Related
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2016
- 2016-08-17 US US15/239,014 patent/US9878972B2/en not_active Expired - Lifetime
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2018
- 2018-01-19 US US15/875,101 patent/US20180141891A1/en not_active Abandoned
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2019
- 2019-07-23 US US16/519,491 patent/US10947177B2/en not_active Expired - Fee Related
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2020
- 2020-02-07 US US16/784,720 patent/US20200181057A1/en not_active Abandoned
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2021
- 2021-10-06 US US17/495,141 patent/US11292758B2/en not_active Expired - Lifetime
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2022
- 2022-04-04 US US17/712,566 patent/US20220289660A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000057701A1 (en) * | 1999-03-31 | 2000-10-05 | United Therapeutics Corporation | Prostaglandin compounds, compositions and methods of treating peripheral vascular disease and pulmonary hypertension |
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