KR101060539B1 - Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 - Google Patents

Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Download PDF

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Publication number
KR101060539B1
KR101060539B1 KR1020087021067A KR20087021067A KR101060539B1 KR 101060539 B1 KR101060539 B1 KR 101060539B1 KR 1020087021067 A KR1020087021067 A KR 1020087021067A KR 20087021067 A KR20087021067 A KR 20087021067A KR 101060539 B1 KR101060539 B1 KR 101060539B1
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KR
South Korea
Prior art keywords
carboxylic acid
thiazole
formula
phenyl
dimethoxy
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Expired - Fee Related
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KR1020087021067A
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English (en)
Korean (ko)
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KR20080090550A (ko
Inventor
존 프레데릭 보일랜
?컸? 차이
나데 포뚜이
폴 길레스피
주니어 로버트 앨런 굿나우
캉 르
크리스토프 미슈
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에프. 호프만-라 로슈 아게
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Publication of KR20080090550A publication Critical patent/KR20080090550A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020087021067A 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드 Expired - Fee Related KR101060539B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27
US60/776,964 2006-02-27
PCT/EP2007/051541 WO2007096315A1 (en) 2006-02-27 2007-02-19 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as plk1 inhibitors

Publications (2)

Publication Number Publication Date
KR20080090550A KR20080090550A (ko) 2008-10-08
KR101060539B1 true KR101060539B1 (ko) 2011-08-30

Family

ID=38051896

Family Applications (1)

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KR1020087021067A Expired - Fee Related KR101060539B1 (ko) 2006-02-27 2007-02-19 Ｐｌｋ1 저해제로서의 4-페닐-티아졸-5-카르복실산 및 4-페닐-티아졸-5-카르복실산 아미드

Country Status (19)

Country Link
US (1) US7504513B2 (OSRAM)
EP (1) EP1991543A1 (OSRAM)
JP (1) JP2009528284A (OSRAM)
KR (1) KR101060539B1 (OSRAM)
CN (1) CN101415704A (OSRAM)
AR (1) AR059621A1 (OSRAM)
AU (1) AU2007217575A1 (OSRAM)
BR (1) BRPI0710473A2 (OSRAM)
CA (1) CA2642921A1 (OSRAM)
CR (1) CR10206A (OSRAM)
EC (1) ECSP088700A (OSRAM)
IL (1) IL193481A0 (OSRAM)
MA (1) MA30260B1 (OSRAM)
MX (1) MX2008010884A (OSRAM)
NO (1) NO20083708L (OSRAM)
RU (1) RU2008138163A (OSRAM)
TW (1) TW200745097A (OSRAM)
WO (1) WO2007096315A1 (OSRAM)
ZA (1) ZA200807074B (OSRAM)

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US8412867B2 (en) * 2007-06-08 2013-04-02 Nec Corporation Semiconductor integrated circuit and filter and informational delivery method using same
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
CN102056607B (zh) * 2008-04-17 2014-07-30 约翰·霍普金斯大学 On01910.na促进在抗药性肿瘤中化学治疗剂的活性
ES2388570T3 (es) * 2008-09-10 2012-10-16 Datalase Ltd Medio de almacenamiento de datos
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
CA2745596A1 (en) * 2008-12-18 2010-10-28 F. Hoffmann-La Roche Ag Thiazolyl-benzimidazoles
US9139589B2 (en) 2009-01-30 2015-09-22 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2603216A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
TW201217365A (en) 2010-08-11 2012-05-01 Millennium Pharm Inc Heteroaryls and uses thereof
UY33671A (es) 2010-10-13 2012-04-30 Millenium Pharmaceuticals Inc Heteroarilos y sus usos

Citations (1)

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WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
DE60143041D1 (de) 2000-08-10 2010-10-21 Pfizer Italia Srl Bizyklische pyrazole wirksam als kinase inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
AU2003206946A1 (en) 2002-02-22 2003-09-09 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
WO2003072554A1 (fr) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Composes d'azole
ES2373945T3 (es) 2002-02-28 2012-02-10 Temple University - Of The Commonwealth System Of Higher Education Bencilsulfonas de (e)-2,6-dialcoxiestirilo amino sustituido sustituidas en 4 para tratar trastornos proliferativos.
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
KR20040106451A (ko) 2002-05-03 2004-12-17 쉐링 악티엔게젤샤프트 폴로-유사 키나제 억제제로서의 티아졸리디논 및 그의 용도
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
MXPA05001544A (es) 2002-08-08 2005-04-19 Smithkline Beecham Corp Compuestos de tiofeno.
WO2004043936A1 (ja) 2002-11-14 2004-05-27 Kyowa Hakko Kogyo Co., Ltd. Ｐｌｋ阻害剤
WO2004046317A2 (en) 2002-11-14 2004-06-03 Massachusetts Institue Of Technology Products and processes for modulating peptide-peptide binding domain interactions
JP3837670B2 (ja) 2002-12-12 2006-10-25 富士通株式会社 データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
EP1597251B1 (en) 2003-02-20 2009-06-10 SmithKline Beecham Corporation Pyrimidine compounds
JP2006522127A (ja) 2003-04-01 2006-09-28 スミスクライン ビーチャム コーポレーション イミダゾトリアジン化合物
KR20070092333A (ko) 2003-06-24 2007-09-12 화이자 프로덕츠 인크. 1-[(벤조이미다졸-1-일)퀴놀린-8-일]피페리딘-4-일아민유도체의 제조 방법
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
JP5164380B2 (ja) 2003-10-21 2013-03-21 サイクラセル リミテッド ピリミジン−４−イル−３，４−チオン化合物及び治療におけるその使用
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

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WO2005075470A1 (en) * 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
ZA200807074B (en) 2009-10-28
AU2007217575A1 (en) 2007-08-30
MA30260B1 (fr) 2009-03-02
MX2008010884A (es) 2008-09-03
NO20083708L (no) 2008-09-23
IL193481A0 (en) 2009-05-04
CN101415704A (zh) 2009-04-22
JP2009528284A (ja) 2009-08-06
TW200745097A (en) 2007-12-16
KR20080090550A (ko) 2008-10-08
ECSP088700A (es) 2008-09-29
AR059621A1 (es) 2008-04-16
US7504513B2 (en) 2009-03-17
BRPI0710473A2 (pt) 2011-08-16
US20070203210A1 (en) 2007-08-30
RU2008138163A (ru) 2010-04-10
EP1991543A1 (en) 2008-11-19
WO2007096315A1 (en) 2007-08-30
CR10206A (es) 2008-09-22
CA2642921A1 (en) 2007-08-30

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