KR101059614B1 - 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제 - Google Patents
11-베타-히드록시스테로이드 데히드로게나제 1의 억제제 Download PDFInfo
- Publication number
- KR101059614B1 KR101059614B1 KR1020087025921A KR20087025921A KR101059614B1 KR 101059614 B1 KR101059614 B1 KR 101059614B1 KR 1020087025921 A KR1020087025921 A KR 1020087025921A KR 20087025921 A KR20087025921 A KR 20087025921A KR 101059614 B1 KR101059614 B1 KR 101059614B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- halogens
- compound
- dichloro
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC1(*)C(*)=CC(*)=C(CC(CCN2*)C2=O)C(*)=C1 Chemical compound CC1(*)C(*)=CC(*)=C(CC(CCN2*)C2=O)C(*)=C1 0.000 description 12
- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- VKEZZGBUHSYSJM-CYBMUJFWSA-N C=CCCC(N([C@H](Cc1ccccc1)CO1)C1=O)=O Chemical compound C=CCCC(N([C@H](Cc1ccccc1)CO1)C1=O)=O VKEZZGBUHSYSJM-CYBMUJFWSA-N 0.000 description 1
- UZRXHHMTKCJKTQ-UHFFFAOYSA-N CC(C)N(CC1)CCC1O Chemical compound CC(C)N(CC1)CCC1O UZRXHHMTKCJKTQ-UHFFFAOYSA-N 0.000 description 1
- HZZCSLKKNXVQSN-UHFFFAOYSA-N CC(N(CC1)CCC1(F)F)=O Chemical compound CC(N(CC1)CCC1(F)F)=O HZZCSLKKNXVQSN-UHFFFAOYSA-N 0.000 description 1
- MIVVZXIGPMBJIL-UHFFFAOYSA-N CCC(N(CC1)CCC1C(F)(F)F)=O Chemical compound CCC(N(CC1)CCC1C(F)(F)F)=O MIVVZXIGPMBJIL-UHFFFAOYSA-N 0.000 description 1
- BAUWRHPMUVYFOD-UHFFFAOYSA-N CN(CC1)CCC1O Chemical compound CN(CC1)CCC1O BAUWRHPMUVYFOD-UHFFFAOYSA-N 0.000 description 1
- UUIFUKWNHUAZTE-INIZCTEOSA-N N#Cc(cc1)ccc1Oc1cc(Cl)c(C[C@H](CCN2N(CC3)CCC3O)C2=O)c(Cl)c1 Chemical compound N#Cc(cc1)ccc1Oc1cc(Cl)c(C[C@H](CCN2N(CC3)CCC3O)C2=O)c(Cl)c1 UUIFUKWNHUAZTE-INIZCTEOSA-N 0.000 description 1
- OJOFMLDBXPDXLQ-SECBINFHSA-N O=C1OC[C@@H](Cc2ccccc2)N1 Chemical compound O=C1OC[C@@H](Cc2ccccc2)N1 OJOFMLDBXPDXLQ-SECBINFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74547506P | 2006-04-24 | 2006-04-24 | |
| US60/745,475 | 2006-04-24 | ||
| PCT/US2007/067182 WO2007127688A2 (en) | 2006-04-24 | 2007-04-23 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090034797A KR20090034797A (ko) | 2009-04-08 |
| KR101059614B1 true KR101059614B1 (ko) | 2011-08-25 |
Family
ID=38564359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087025921A Expired - Fee Related KR101059614B1 (ko) | 2006-04-24 | 2007-04-23 | 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8153807B2 (https=) |
| EP (1) | EP2021336B1 (https=) |
| JP (1) | JP5269765B2 (https=) |
| KR (1) | KR101059614B1 (https=) |
| CN (1) | CN101432275B (https=) |
| AT (1) | ATE472542T1 (https=) |
| AU (1) | AU2007244955B2 (https=) |
| BR (1) | BRPI0710467A2 (https=) |
| CA (1) | CA2646624C (https=) |
| CO (1) | CO6140034A2 (https=) |
| CR (2) | CR10402A (https=) |
| CY (1) | CY1110753T1 (https=) |
| DE (1) | DE602007007473D1 (https=) |
| DK (1) | DK2021336T3 (https=) |
| EA (1) | EA015106B1 (https=) |
| EC (1) | ECSP088833A (https=) |
| ES (1) | ES2345792T3 (https=) |
| HR (1) | HRP20100397T1 (https=) |
| IL (1) | IL194810A (https=) |
| MA (1) | MA30686B1 (https=) |
| MX (1) | MX2008013649A (https=) |
| MY (1) | MY148079A (https=) |
| NO (1) | NO20084318L (https=) |
| NZ (1) | NZ571176A (https=) |
| PL (1) | PL2021336T3 (https=) |
| PT (1) | PT2021336E (https=) |
| RS (1) | RS51450B (https=) |
| SI (1) | SI2021336T1 (https=) |
| TN (1) | TNSN08417A1 (https=) |
| UA (1) | UA94741C2 (https=) |
| WO (1) | WO2007127688A2 (https=) |
| ZA (1) | ZA200808687B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA014718B1 (ru) * | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| JP5161869B2 (ja) * | 2006-04-21 | 2013-03-13 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| CN101432263B (zh) | 2006-04-24 | 2012-03-07 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1抑制剂的取代的吡咯烷酮类 |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| JP5101602B2 (ja) | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| CN101432265B (zh) | 2006-04-25 | 2011-12-14 | 伊莱利利公司 | 11-β-羟类固醇脱氢酶1的抑制剂 |
| DK2049513T3 (da) * | 2006-04-28 | 2012-02-27 | Lilly Co Eli | Piperidinylsubstituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| TWI822716B (zh) * | 2017-12-21 | 2023-11-21 | 大陸商廣東眾生睿創生物科技有限公司 | 作為ppar促效劑的吡咯啶衍生物的非晶形及其製備方法 |
| CN110483514B (zh) | 2019-09-16 | 2022-06-14 | 启元生物(杭州)有限公司 | 一种氰基取代的环肼衍生物及其应用 |
| CN110724142B (zh) * | 2019-10-29 | 2022-09-02 | 启元生物(杭州)有限公司 | 一种作为jak激酶抑制剂的酰胺或磺酰胺取代的肼衍生物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| WO2005108361A1 (en) | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005240784C1 (en) | 2004-05-07 | 2011-12-22 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| US7713979B2 (en) * | 2004-10-29 | 2010-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ES2547724T3 (es) | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
| WO2006068992A1 (en) | 2004-12-20 | 2006-06-29 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| DE602005008282D1 (de) | 2004-12-21 | 2008-08-28 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
| WO2007066921A1 (en) * | 2005-12-08 | 2007-06-14 | Ho Young Lee | Structure of sticking extraneous matter and warm foot digital compression plate |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| JP5161869B2 (ja) | 2006-04-21 | 2013-03-13 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA014718B1 (ru) * | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| CN101432263B (zh) * | 2006-04-24 | 2012-03-07 | 伊莱利利公司 | 作为11-β-羟类固醇脱氢酶1抑制剂的取代的吡咯烷酮类 |
| EA016415B1 (ru) | 2006-04-24 | 2012-04-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1 |
| DK2021337T3 (da) * | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| CN101432265B (zh) | 2006-04-25 | 2011-12-14 | 伊莱利利公司 | 11-β-羟类固醇脱氢酶1的抑制剂 |
| JP5101602B2 (ja) * | 2006-04-25 | 2012-12-19 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| DK2049513T3 (da) | 2006-04-28 | 2012-02-27 | Lilly Co Eli | Piperidinylsubstituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| US20090008890A1 (en) * | 2007-06-13 | 2009-01-08 | Woodford James R | Suspension system for an all-terrain vehicle |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
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2007
- 2007-04-23 JP JP2009507912A patent/JP5269765B2/ja not_active Expired - Fee Related
- 2007-04-23 RS RSP-2010/0399A patent/RS51450B/sr unknown
- 2007-04-23 DE DE602007007473T patent/DE602007007473D1/de active Active
- 2007-04-23 CN CN2007800149090A patent/CN101432275B/zh not_active Expired - Fee Related
- 2007-04-23 UA UAA200812287A patent/UA94741C2/ru unknown
- 2007-04-23 EA EA200870470A patent/EA015106B1/ru not_active IP Right Cessation
- 2007-04-23 KR KR1020087025921A patent/KR101059614B1/ko not_active Expired - Fee Related
- 2007-04-23 BR BRPI0710467-7A patent/BRPI0710467A2/pt not_active IP Right Cessation
- 2007-04-23 PL PL07761091T patent/PL2021336T3/pl unknown
- 2007-04-23 WO PCT/US2007/067182 patent/WO2007127688A2/en not_active Ceased
- 2007-04-23 AT AT07761091T patent/ATE472542T1/de active
- 2007-04-23 CA CA2646624A patent/CA2646624C/en not_active Expired - Fee Related
- 2007-04-23 MX MX2008013649A patent/MX2008013649A/es active IP Right Grant
- 2007-04-23 ES ES07761091T patent/ES2345792T3/es active Active
- 2007-04-23 SI SI200730353T patent/SI2021336T1/sl unknown
- 2007-04-23 AU AU2007244955A patent/AU2007244955B2/en not_active Ceased
- 2007-04-23 EP EP07761091A patent/EP2021336B1/en active Active
- 2007-04-23 NZ NZ571176A patent/NZ571176A/en not_active IP Right Cessation
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| WO2005108361A1 (en) | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
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