KR100962566B1 - 인간 성장호르몬을 유효성분으로 포함하는 피부 상태 개선용 조성물 - Google Patents
인간 성장호르몬을 유효성분으로 포함하는 피부 상태 개선용 조성물 Download PDFInfo
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KR (1) | KR100962566B1 (fr) |
BR (1) | BRPI0520672B1 (fr) |
CA (1) | CA2625806C (fr) |
WO (1) | WO2007043721A1 (fr) |
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US11712407B2 (en) | 2014-12-30 | 2023-08-01 | Celltrion, Inc. | Hybrid-type multi-lamellar nanostructure of epidermal growth factor and liposome and method for manufacturing same |
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KR100705981B1 (ko) | 2005-10-12 | 2007-04-10 | 주식회사 리제론 | 인간 성장호르몬을 포함하는 탈모방지 또는 발모촉진용조성물 |
KR102143557B1 (ko) * | 2013-08-09 | 2020-08-12 | 주식회사 리제론 | 인간 열 활성화 단백질 90a의 절편을 유효성분으로 포함하는 피부상태 개선용 조성물 |
FR3034662B1 (fr) * | 2015-04-10 | 2020-08-28 | Isp Investments Inc | Nouvelles utilisations du peptide de sequence his-d-trp-ala-trp-d-phe-lys-nh2 pour diminuer ou retarder l'apparition de la senescence cellulaire et des signes du vieillissement cutane |
CN106905517A (zh) * | 2017-04-20 | 2017-06-30 | 福建中锦新材料有限公司 | 一种用于纺丝的聚酰胺6及其制造方法 |
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JP2002234845A (ja) * | 2001-02-09 | 2002-08-23 | Naris Cosmetics Co Ltd | 皮膚外用剤 |
JP2004035573A (ja) * | 2003-10-27 | 2004-02-05 | Kyowa Industrial Co Ltd | ゴマージュ化粧料組成物 |
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- 2005-10-12 BR BRPI0520672-3A patent/BRPI0520672B1/pt active IP Right Grant
- 2005-10-12 KR KR1020097007068A patent/KR100962566B1/ko active IP Right Grant
- 2005-10-12 CA CA2625806A patent/CA2625806C/fr not_active Expired - Fee Related
- 2005-10-12 WO PCT/KR2005/003402 patent/WO2007043721A1/fr active Application Filing
- 2005-10-12 JP JP2008535427A patent/JP5649278B2/ja active Active
Non-Patent Citations (1)
Title |
---|
In. J. Clin. Endocrinol. Metab., Vol.84, No.5, pp1638-1644 (1999.) |
Cited By (1)
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US11712407B2 (en) | 2014-12-30 | 2023-08-01 | Celltrion, Inc. | Hybrid-type multi-lamellar nanostructure of epidermal growth factor and liposome and method for manufacturing same |
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KR20090042871A (ko) | 2009-04-30 |
BRPI0520672B1 (pt) | 2020-11-10 |
WO2007043721A1 (fr) | 2007-04-19 |
CA2625806C (fr) | 2011-08-02 |
JP2009511574A (ja) | 2009-03-19 |
CA2625806A1 (fr) | 2007-04-19 |
JP5649278B2 (ja) | 2015-01-07 |
BRPI0520672A2 (pt) | 2009-05-19 |
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