JP2009511574A - ヒト成長ホルモンを有効成分として含む皮膚状態改善用組成物。 - Google Patents
ヒト成長ホルモンを有効成分として含む皮膚状態改善用組成物。 Download PDFInfo
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- JP2009511574A JP2009511574A JP2008535427A JP2008535427A JP2009511574A JP 2009511574 A JP2009511574 A JP 2009511574A JP 2008535427 A JP2008535427 A JP 2008535427A JP 2008535427 A JP2008535427 A JP 2008535427A JP 2009511574 A JP2009511574 A JP 2009511574A
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Abstract
【解決手段】本発明は、ヒト成長ホルモンを有効成分として含む皮膚状態改善用皮膚局所表面投与組成物を提供する。また、本発明は、ヒト成長ホルモンを有効成分として含む組成物を、皮膚に局所的に塗布する段階を含む皮膚状態改善方法を提供する。
【選択図】 図1
Description
<発明の構成>
<発明の具体的実施例>
<<実施例I:様々な剤形のヒト成長ホルモン−含有リポソーム(Lipo−hGH)の製造方法>>
<<<A型(クリーム型):ヒト成長ホルモン−含有クリーム剤形>>>
<<<B型(リポソーム型):ヒト成長ホルモン−含有リポソーム剤形>>>
<<実施例II:FPLC分離及びSDS−PAGE分析>>
<<実施例III:リポソーム内のヒト成長ホルモンの定量>>
<<実施例IV:リン脂質含量の分析>>
<<実施例V:安定性試験>>
<<実施例VI:安定性試験>>
<<実施例VII:ナノリポソーム剤形のLipo−hGHのNb2細胞増殖の分析>>
<<実施例VIII:粒子大きさ分布の分析>>
<<実施例IX:シワ改善効能の分析>>
<<実施例X:ニキビ治療効能の分析>>
<<実施例XI:シミ除去効能の分析>>
<<実施例XII:ナノリポソーム剤形のLipo−hGHのローカリゼーション及び皮膚に及ぼす影響の分析>>
<<実施例XIII:ナノリポソーム剤形のLipo−hGHがマウス皮膚に及ぼす影響の分析>>
<<実施例XIV:ナノリポソーム剤形のLipo−hGHが人工皮膚に及ぼす影響の分析>>
Claims (6)
- ヒト成長ホルモンを有効成分として含む、皮膚状態改善用皮膚局所表面投与組成物。
- 前記ヒト成長ホルモンは、リポソームに包囲されていることを特徴とする、請求項1に記載の皮膚状態改善用皮膚局所表面投与組成物。
- 前記リポソームは、ナノリポソームであることを特徴とする、請求項2に記載の皮膚状態改善用皮膚局所表面投与組成物。
- 前記ナノリポソームは、50〜250nmの粒子サイズを有することを特徴とする、請求項3に記載の皮膚状態改善用皮膚局所表面投与組成物。
- 前記皮膚状態の改善は、ニキビの治療、シワの改善、シミの除去、皮膚弾力の改善、発毛の促進、皮膚老化の防止、皮膚保湿の改善、または皮膚表皮幹細胞の増殖であることを特徴とする、請求項1に記載の皮膚状態改善用皮膚局所表面投与組成物。
- 前記組成物は、化粧料組成物または薬剤学的組成物であることを特徴とする、請求項1に記載の皮膚状態改善用皮膚局所表面投与組成物。
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PCT/KR2005/003402 WO2007043721A1 (en) | 2005-10-12 | 2005-10-12 | Compositions for improving skin conditions comprising human growth hormones as an active ingredient |
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JP2014163596A Division JP5913479B2 (ja) | 2014-08-11 | 2014-08-11 | ヒト成長ホルモンを有効成分として含む発毛の促進用の組成物 |
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JP2009511574A true JP2009511574A (ja) | 2009-03-19 |
JP5649278B2 JP5649278B2 (ja) | 2015-01-07 |
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JP (1) | JP5649278B2 (ja) |
KR (1) | KR100962566B1 (ja) |
BR (1) | BRPI0520672B1 (ja) |
CA (1) | CA2625806C (ja) |
WO (1) | WO2007043721A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016527309A (ja) * | 2013-08-09 | 2016-09-08 | リジェロン,インコーポレーテッド | 活性成分としてヒト熱ショックタンパク質90aの断片を含む皮膚状態を改善する組成物 |
CN106905517A (zh) * | 2017-04-20 | 2017-06-30 | 福建中锦新材料有限公司 | 一种用于纺丝的聚酰胺6及其制造方法 |
JP2018513148A (ja) * | 2015-04-10 | 2018-05-24 | アイエスピー・インヴェストメンツ・リミテッド・ライアビリティ・カンパニー | 細胞老化および皮膚加齢徴候の出現を低減または遅延させるための配列His−D−Trp−Ala−Trp−D−Phe−Lys−NH2を有するペプチドの新規な使用 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100705981B1 (ko) | 2005-10-12 | 2007-04-10 | 주식회사 리제론 | 인간 성장호르몬을 포함하는 탈모방지 또는 발모촉진용조성물 |
CN107106421B (zh) | 2014-12-30 | 2020-10-27 | 赛特瑞恩股份有限公司 | 表皮生长因子和脂质体的混合型多层纳米结构及其制造方法 |
Citations (4)
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JP2001233727A (ja) * | 2000-02-22 | 2001-08-28 | Musashino Meneki Kenkyusho:Kk | 化粧品 |
JP2002179528A (ja) * | 2000-12-14 | 2002-06-26 | Japan Natural Laboratory Co Ltd | ピーリング化粧剤およびピーリング石鹸 |
JP2002234845A (ja) * | 2001-02-09 | 2002-08-23 | Naris Cosmetics Co Ltd | 皮膚外用剤 |
JP2004035573A (ja) * | 2003-10-27 | 2004-02-05 | Kyowa Industrial Co Ltd | ゴマージュ化粧料組成物 |
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2005
- 2005-10-12 KR KR1020097007068A patent/KR100962566B1/ko active IP Right Grant
- 2005-10-12 CA CA2625806A patent/CA2625806C/en not_active Expired - Fee Related
- 2005-10-12 JP JP2008535427A patent/JP5649278B2/ja active Active
- 2005-10-12 BR BRPI0520672-3A patent/BRPI0520672B1/pt active IP Right Grant
- 2005-10-12 WO PCT/KR2005/003402 patent/WO2007043721A1/en active Application Filing
Patent Citations (4)
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JP2001233727A (ja) * | 2000-02-22 | 2001-08-28 | Musashino Meneki Kenkyusho:Kk | 化粧品 |
JP2002179528A (ja) * | 2000-12-14 | 2002-06-26 | Japan Natural Laboratory Co Ltd | ピーリング化粧剤およびピーリング石鹸 |
JP2002234845A (ja) * | 2001-02-09 | 2002-08-23 | Naris Cosmetics Co Ltd | 皮膚外用剤 |
JP2004035573A (ja) * | 2003-10-27 | 2004-02-05 | Kyowa Industrial Co Ltd | ゴマージュ化粧料組成物 |
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Title |
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JPN6011005032; Kanga,V.: 'Sophisticated cosmetic ingredients' Househ. Pers. Prod. Ind. Vol.42,No.6, P.55,56,58,60,61 * |
JPN6011005034; 松山淳 外4名: '(財) 博慈会 老人病研究所 紀要Vol.12(総説) 『本邦におけるアンチ・エイジング医療の実情』' 未病と抗老化 Vol.12,No.1, 200308, P.23-29, 博慈会老人病研究所 * |
JPN6014017745; Journal of Clinical Endocrinology and Metabolism Vol.83, No.2, 1998, p.382-395 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016527309A (ja) * | 2013-08-09 | 2016-09-08 | リジェロン,インコーポレーテッド | 活性成分としてヒト熱ショックタンパク質90aの断片を含む皮膚状態を改善する組成物 |
JP2018513148A (ja) * | 2015-04-10 | 2018-05-24 | アイエスピー・インヴェストメンツ・リミテッド・ライアビリティ・カンパニー | 細胞老化および皮膚加齢徴候の出現を低減または遅延させるための配列His−D−Trp−Ala−Trp−D−Phe−Lys−NH2を有するペプチドの新規な使用 |
CN106905517A (zh) * | 2017-04-20 | 2017-06-30 | 福建中锦新材料有限公司 | 一种用于纺丝的聚酰胺6及其制造方法 |
Also Published As
Publication number | Publication date |
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BRPI0520672B1 (pt) | 2020-11-10 |
KR100962566B1 (ko) | 2010-06-11 |
BRPI0520672A2 (pt) | 2009-05-19 |
WO2007043721A1 (en) | 2007-04-19 |
JP5649278B2 (ja) | 2015-01-07 |
KR20090042871A (ko) | 2009-04-30 |
CA2625806A1 (en) | 2007-04-19 |
CA2625806C (en) | 2011-08-02 |
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