KR100933721B1 - 저함량의 4'-o-메틸 피리독신 및/또는 비플라본을 가지는은행나무 추출물의 개선된 제조방법 - Google Patents
저함량의 4'-o-메틸 피리독신 및/또는 비플라본을 가지는은행나무 추출물의 개선된 제조방법 Download PDFInfo
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Abstract
Description
추출물 | 실시예 1 | 비교예 1 | 실시예 2a) | 실시예 2b) | 비교예 2 | 비교예 3 |
플라보노이드[%] | 24.86 | 24.51 | 27.17 | 25.32 | 25.89 | 22.78 |
징코글라이드 A,B,C[%] | 3.28 | 2.94 | 2.97 | 3.04 | 2.97 | 3.40 |
빌로발라이드[%] | 3.17 | 3.03 | 3.18 | 3.14 | 3.07 | 3.07 |
테르펜 락톤[%] | 6.45 | 5.97 | 6.15 | 6.18 | 6.04 | 6.47 |
징코산[ppm] | < 5 | < 5 | < 5 | < 5 | < 5 | < 5 |
4'-O-메틸 피리독신 [ppm] | 0.4 | 104.5 | 164 | 0.8 | 89 | 52 |
아멘토플라본[ppm] | 68.5 | 78.7 | n.d.(< 1) | n.d.(< 1) | 81.6 | 12.6 |
빌로베틴[ppm] | 123.3 | 120.4 | n.d.(< 1) | n.d.(< 1) | 136.4 | 10.4 |
징코제틴[ppm] | 86.3 | 82.1 | n.d.(< 1) | n.d.(< 1) | 86.1 | 2.7 |
이소징코제틴[ppm] | 103.3 | 104.4 | n.d.(< 1) | n.d.(< 1) | 111.5 | 4.8 |
사이아도피신[ppm] | 44.0 | 43.0 | n.d.(< 1) | n.d.(< 1) | 44.0 | 0.8 |
비플라본의 총량[ppm] | 425.4 | 428.6 | n.d.(< 5) | n.d.(< 5) | 459.6 | 31.3 |
Claims (15)
- 다음 단계를 포함하는, 감소된 함량의 4'-O-메틸 피리독신(4'-O-methyl pyridoxine) 및/또는 비플라본(biflavones)을 가지는 은행나무 추출물의 제조방법:a) 물-함유 아세톤(acetone), 탄소원자 1~3개를 갖는 물-함유 알칸올(alkanol) 또는 무수메탄올(anhydrous methanol)을 이용하여 은행나무 잎을 추출하는 단계;b) 상기 용매를 10중량% 이하 함량으로 농축하여 유기 용매를 분리하는 단계; 이 때, 마지막 증류단계에서 물이 첨가될 수도 있음.c) 5~25중량%의 고체함량이 되도록 잔류 수용액을 물로 희석하고, 25℃이하로 냉각한 다음, 침전물이 형성될 때까지 방치하는 단계;d) 잔류 수용액을 황산암모늄(ammonium sulfate)으로 처리한 다음, 메틸에틸케톤(methyl ethyl ketone) 또는 메틸에틸케톤과 아세톤의 혼합물을 이용하여 적어도 한번 추출하는 단계;e) 상기 수득된 추출물을 농축한 다음, 10중량%의 고체함량에서 50중량%의 물 및 50중량%의 에탄올을 함유하는 용액을 수득하기 위하여 에탄올-물 혼합물로 희석하는 단계;f) 상기 용액을 납 화합물 또는 불용성 폴리아마이드로 처리하는 단계;g) 60~100℃의 끓는점을 갖는 지방족(aliphatic) 또는 지환족(cycloaliphatic) 용매를 사용하여 상기 여과된 용액을 추출하는 단계;h) 잔류 수성-알콜성 용액을 농축한 다음, 황산암모늄으로 처리하고, 메틸에틸케톤 및 에탄올로 추출하는 단계;i) 50~70중량%의 고체함량이 되도록 상기 수득된 유기상을 농축하는 단계;k) 탄소원자 1~3개를 갖는 수성 알칸올에서 상기 농축물을 용해시킨 다음, 선택적으로 여과하는 단계;l) 비플라본의 함량을 감소시키는 흡착수지로서 선택적으로 치환된 스티렌계/디비닐벤젠계 기반 수지 및/또는 4'-O-메틸 피리독신의 함량을 감소시키는 강산성 이온 교환체로 여과하는 단계, 이 때, 상기 제거되는 물질은 수지 상에 잔여함, 및m) 5% 미만의 물 함량을 갖는 건조 추출물을 수득하기 위하여 감소된 압력에서 상기 농축물을 건조하는 단계.
- 제1항에 있어서, k)단계에서 상기 수성 알칸올은 수성 에탄올인 것을 특징으로 하는 방법.
- 제2항에 있어서, 상기 수성 에탄올은 에탄올 함량이 40~60중량%인 것을 특징으로 하는 방법.
- 삭제
- 삭제
- 다음의 함량을 가지는 것을 특징으로 하는 은행나무 잎 추출물:·케르세틴(quercetin), 캠퍼롤(kaempferol) 및 이소함네틴 글리코사이드(isohamnetin glycosides)으로 구성된 그룹으로부터 선택되는 플라보노이드(flavonoids) 20~30중량%;·테르펜 락톤(terpene lactones) 4.5~8.5중량%;·징코산(ginkgolic acids) 10ppm 미만;· 4'-O-메틸 피리독신 10ppm 미만; 및/또는· 아멘토플라본(amentoflavone), 빌로베틴(bilobetin), 징크제틴(ginkgetin), 이소징크제틴(isoginkgetin) 및 사이아도피신(sciadopitysin)으로 구성된 그룹으로부터 선택되는 비플라본 20ppm 미만.
- 제6항에 있어서, 4'-O-메틸 피리독신 함량이 2ppm 미만인 것을 특징으로 하는 추출물.
- 제6항에 있어서, 비플라본 함량이 10ppm 미만인 것을 특징으로 하는 추출물.
- 제6항에 있어서, 비플라본 함량이 5ppm 미만인 것을 특징으로 하는 추출물.
- 삭제
- 제6항에 있어서, 다음의 함량을 가지는 것을 특징으로 하는 추출물:·케르세틴, 캠퍼롤 및 이소함네틴 글리코사이드로 구성된 그룹으로부터 선택되는 플라보노이드 22.0~27.0중량%,·테르펜 락톤 5.0~7.0중량%, 및·징코산 5ppm이하.
- 제6항에 있어서, 다음의 함량을 가지는 것을 특징으로 하는 추출물:·케르세틴, 캠퍼롤 및 이소함네틴 글리코사이드로 구성된 그룹으로부터 선택되는 플라보노이드 22.0~27.0중량%,·징코라이드(ginkgolides) A, B 및 C 전체 2.8~3.4중량%,·빌로발라이드(bilobalid) 2.6~3.2중량%, 및·징코산 5ppm이하.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005020685.9 | 2005-05-03 | ||
DE102005020685 | 2005-05-03 | ||
DE102005061948.7 | 2005-12-23 | ||
DE102005061948A DE102005061948A1 (de) | 2005-05-03 | 2005-12-23 | Verbessertes Verfahren zur Herstellung von 4'-O-Methylpyridoxin- und/oder Biflavon-armen Ginkgoextrakten |
PCT/EP2006/004029 WO2006117169A1 (en) | 2005-05-03 | 2006-04-28 | Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones |
Publications (2)
Publication Number | Publication Date |
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KR20070112271A KR20070112271A (ko) | 2007-11-22 |
KR100933721B1 true KR100933721B1 (ko) | 2009-12-24 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020077023531A KR100933721B1 (ko) | 2005-05-03 | 2006-04-28 | 저함량의 4'-o-메틸 피리독신 및/또는 비플라본을 가지는은행나무 추출물의 개선된 제조방법 |
Country Status (26)
Country | Link |
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US (2) | US20060251746A1 (ko) |
EP (1) | EP1868625B1 (ko) |
JP (2) | JP4304230B2 (ko) |
KR (1) | KR100933721B1 (ko) |
CN (2) | CN101175505A (ko) |
AR (1) | AR054270A1 (ko) |
AT (1) | ATE401903T1 (ko) |
AU (1) | AU2006243378B2 (ko) |
BR (1) | BRPI0611093B1 (ko) |
CA (1) | CA2606843C (ko) |
DE (2) | DE102005061948A1 (ko) |
DK (1) | DK1868625T3 (ko) |
DO (1) | DOP2006000091A (ko) |
ES (1) | ES2310408T3 (ko) |
JO (1) | JO2523B1 (ko) |
MX (1) | MX2007013398A (ko) |
MY (1) | MY143650A (ko) |
NZ (1) | NZ563818A (ko) |
PE (1) | PE20061296A1 (ko) |
PL (1) | PL1868625T3 (ko) |
PT (1) | PT1868625E (ko) |
RU (1) | RU2367459C2 (ko) |
SI (1) | SI1868625T1 (ko) |
TW (1) | TWI376230B (ko) |
UA (1) | UA84519C2 (ko) |
WO (1) | WO2006117169A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101788099B1 (ko) * | 2014-02-10 | 2017-10-19 | 닥터 빌마르 쉬바베 게엠바하 운트 코 카게 | 은행나무 추출물의 개선된 제조방법 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE041715T2 (hu) * | 2007-12-21 | 2019-05-28 | Dr Willmar Schwabe Gmbh & Co Kg | Ginkgo biloba levél-kivonat alkalmazása |
EP2494979B1 (de) | 2011-03-04 | 2019-03-27 | Dr. Willmar Schwabe GmbH & Co. KG | Verwendung von Extrakten aus Blättern von Ginkgo biloba zur Prävention und Therapie von Komplikationen nach operativer Arteriosklerose-Behandlung sowie von Folgeerscheinungen der Arteriosklerose |
MX341428B (es) | 2011-04-27 | 2016-08-18 | Dr Willmar Schwabe Gmbh & Co Kg | Tableta de liberacion controlada de extracto de ginkgo biloba y procedimiento para su obtencion. |
CN103919768B (zh) * | 2014-03-30 | 2016-03-16 | 吴静 | 一种含有异银杏双黄酮和白果内酯的药物组合物及其制剂 |
CN107509997B (zh) * | 2017-09-08 | 2021-02-26 | 南京林业大学 | 一种基于内源糖苷酶酶解结合树脂吸附脱除白果致毒成分的方法及其制备的产品和应用 |
CN107647407A (zh) * | 2017-11-14 | 2018-02-02 | 宜昌东方昌绿茶业有限公司 | 一种从银杏茶中提取黄酮素的方法 |
CN113491721B (zh) * | 2020-03-19 | 2022-05-31 | 江苏得乐康生物科技有限公司 | 一种脱除银杏叶提取物中银杏毒素的方法 |
CN115894424B (zh) * | 2023-01-06 | 2023-05-12 | 中日友好医院(中日友好临床医学研究所) | 新型双黄酮类化合物及其制备方法、药物组合物和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US6328999B1 (en) * | 1997-12-19 | 2001-12-11 | Dr. Willmar Schwabe Gmbh & Co. | Ginkgo biloba leaf extracts with a reduced 4′-O-methylpyridoxine and biflavone content |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2627387B1 (fr) * | 1988-02-24 | 1992-06-05 | Fabre Sa Pierre | Procede d'obtention d'un extrait de feuilles de ginkgo biloba |
GB8822004D0 (en) * | 1988-09-20 | 1988-10-19 | Indena Spa | New extracts of ginkgo biloba & their methods of preparation |
DE3940091A1 (de) * | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
JP3518882B2 (ja) | 1993-11-12 | 2004-04-12 | ダイセル化学工業株式会社 | イチョウエキス及びその製造法 |
US20040076691A1 (en) * | 2002-01-16 | 2004-04-22 | David Haines | Anti-inflammatory formulations |
CN1251675C (zh) * | 2004-02-10 | 2006-04-19 | 张正生 | 一种注射用银杏达莫粉针剂及其制备方法 |
CN100451013C (zh) * | 2004-04-21 | 2009-01-14 | 徐州技源天然保健品有限公司 | 一种从卷柏中提取穗花杉双黄酮提取物的生产工艺 |
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- 2005-12-23 DE DE102005061948A patent/DE102005061948A1/de not_active Withdrawn
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---|---|---|---|---|
US6328999B1 (en) * | 1997-12-19 | 2001-12-11 | Dr. Willmar Schwabe Gmbh & Co. | Ginkgo biloba leaf extracts with a reduced 4′-O-methylpyridoxine and biflavone content |
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KR101788099B1 (ko) * | 2014-02-10 | 2017-10-19 | 닥터 빌마르 쉬바베 게엠바하 운트 코 카게 | 은행나무 추출물의 개선된 제조방법 |
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