KR100891266B1 - 안압강하성 지질(프로스타글란딘 유도체)과 티몰롤 조성물및 이의 사용방법 - Google Patents

안압강하성 지질(프로스타글란딘 유도체)과 티몰롤 조성물및 이의 사용방법 Download PDF

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KR100891266B1
KR100891266B1 KR1020037015024A KR20037015024A KR100891266B1 KR 100891266 B1 KR100891266 B1 KR 100891266B1 KR 1020037015024 A KR1020037015024 A KR 1020037015024A KR 20037015024 A KR20037015024 A KR 20037015024A KR 100891266 B1 KR100891266 B1 KR 100891266B1
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delete delete
component
eye
ocular
timolol
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KR1020037015024A
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Korean (ko)
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KR20040007577A (ko
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준 첸
데이비드에프. 우드워드
알렉산더비. 칼람
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알러간, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
KR1020037015024A 2001-05-31 2002-05-30 안압강하성 지질(프로스타글란딘 유도체)과 티몰롤 조성물및 이의 사용방법 KR100891266B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29484501P 2001-05-31 2001-05-31
US60/294,845 2001-05-31
PCT/US2002/017291 WO2002096432A2 (en) 2001-05-31 2002-05-30 Hypotensive lipid (prostaglandin derivatives) and timolol compositions and methods of using same

Publications (2)

Publication Number Publication Date
KR20040007577A KR20040007577A (ko) 2004-01-24
KR100891266B1 true KR100891266B1 (ko) 2009-03-30

Family

ID=23135192

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KR1020037015024A KR100891266B1 (ko) 2001-05-31 2002-05-30 안압강하성 지질(프로스타글란딘 유도체)과 티몰롤 조성물및 이의 사용방법

Country Status (21)

Country Link
US (5) US8629140B2 (pt)
EP (2) EP1392319B1 (pt)
JP (2) JP4475871B2 (pt)
KR (1) KR100891266B1 (pt)
CN (1) CN100391461C (pt)
AR (1) AR035248A1 (pt)
AT (1) ATE506066T1 (pt)
AU (1) AU2002312221B2 (pt)
BR (1) BR0209709A (pt)
CA (1) CA2445386C (pt)
CY (1) CY1111872T1 (pt)
DE (1) DE60239797D1 (pt)
DK (1) DK1392319T3 (pt)
EC (1) ECSP034815A (pt)
ES (1) ES2363077T3 (pt)
HK (1) HK1070830A1 (pt)
MX (1) MXPA03010146A (pt)
NZ (1) NZ528998A (pt)
PT (1) PT1392319E (pt)
TW (1) TWI298257B (pt)
WO (1) WO2002096432A2 (pt)

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US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
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CN102724951A (zh) 2009-11-09 2012-10-10 阿勒根公司 用于刺激毛发生长的组合物和方法
MX2012010684A (es) 2010-03-17 2012-11-06 Novaliq Gmbh Composicion farmaceutica para el tratamiento de la presion intraocular incrementada.
PT2598118T (pt) 2010-07-29 2018-11-29 Allergan Inc Soluções de bimatoprost e timolol isentas de conservantes
US9061034B2 (en) 2010-07-29 2015-06-23 Allergan, Inc. Preservative free bimatoprost and timolol solutions
CA2837240A1 (en) * 2011-05-27 2012-12-06 Ratiopharm Gmbh Ophthalmic preparation comprising a pgf2.alpha. analogue
US9248135B2 (en) * 2012-04-24 2016-02-02 Allergan, Inc. Prostaglandin and vasoconstrictor pharmaceutical compositions and methods of use
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JP2020535156A (ja) 2017-09-27 2020-12-03 ノバリック ゲーエムベーハー 眼疾患の治療に使用するためのラタノプロストを含む眼科用組成物
JP7353292B2 (ja) 2018-03-02 2023-09-29 ノバリック ゲーエムベーハー ネビボロールを含む医薬組成物
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JP7500550B2 (ja) 2018-10-12 2024-06-17 ノバリック ゲーエムベーハー 乾性眼疾患の治療のための眼科用組成物
CN112933096B (zh) * 2019-12-11 2023-06-13 中国科学院上海药物研究所 丁酰噻吗洛尔在制备治疗浅表型、混合型或深部血管瘤的药物中的用途
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WO1997030710A1 (en) * 1996-02-22 1997-08-28 Vision Pharmaceuticals L.P. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

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MXPA03010146A (es) 2004-03-10
CA2445386C (en) 2010-08-24
EP2272518A1 (en) 2011-01-12
AU2002312221B2 (en) 2007-02-15
US8618093B2 (en) 2013-12-31
JP2010031041A (ja) 2010-02-12
US9474760B2 (en) 2016-10-25
US8906907B2 (en) 2014-12-09
BR0209709A (pt) 2004-07-27
US20170112853A1 (en) 2017-04-27
NZ528998A (en) 2005-06-24
PT1392319E (pt) 2011-06-28
AR035248A1 (es) 2004-05-05
WO2002096432A3 (en) 2003-05-08
US20030069286A1 (en) 2003-04-10
KR20040007577A (ko) 2004-01-24
DE60239797D1 (de) 2011-06-01
US10045997B2 (en) 2018-08-14
DK1392319T3 (da) 2011-06-27
CN100391461C (zh) 2008-06-04
US20090181969A1 (en) 2009-07-16
EP1392319B1 (en) 2011-04-20
US8629140B2 (en) 2014-01-14
JP2004532870A (ja) 2004-10-28
WO2002096432A2 (en) 2002-12-05
HK1070830A1 (en) 2005-06-30
US20140051704A1 (en) 2014-02-20
CY1111872T1 (el) 2015-11-04
US20150150880A1 (en) 2015-06-04
ECSP034815A (es) 2004-07-23
TWI298257B (en) 2008-07-01
ATE506066T1 (de) 2011-05-15
CA2445386A1 (en) 2002-12-05
JP4475871B2 (ja) 2010-06-09
EP1392319A2 (en) 2004-03-03
CN1543348A (zh) 2004-11-03
ES2363077T3 (es) 2011-07-20

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