CY1111872T1 - Συνθεσεις υποτασικου λιπιδιου (προσταγλανδινης) και τιμολολης - σχετικες μεθοδοι χρησης - Google Patents

Συνθεσεις υποτασικου λιπιδιου (προσταγλανδινης) και τιμολολης - σχετικες μεθοδοι χρησης

Info

Publication number
CY1111872T1
CY1111872T1 CY20111100642T CY111100642T CY1111872T1 CY 1111872 T1 CY1111872 T1 CY 1111872T1 CY 20111100642 T CY20111100642 T CY 20111100642T CY 111100642 T CY111100642 T CY 111100642T CY 1111872 T1 CY1111872 T1 CY 1111872T1
Authority
CY
Cyprus
Prior art keywords
compositions
ocular hypertension
timololis
prostaglandin
hypothesis
Prior art date
Application number
CY20111100642T
Other languages
English (en)
Inventor
June Chen
David F Woodward
Alexander B Kharlamb
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23135192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111872(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Publication of CY1111872T1 publication Critical patent/CY1111872T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

Οι νέες συνθέσεις και μέθοδοι θεραπείας της οφθαλμικής υπέρτασης εξασφαλίζουν μία αποτελεσματική θεραπεία για την οφθαλμική υπέρταση χρησιμοποιώντας συνήθως μειωμένες συγκεντρώσεις ενεργών συστατικών. Αυτές οι συνθέσεις περιλαμβάνουν ένα συστατικό της τιμολόλης και ένα συστατικό του υποτασικού λιπιδίου. Οι παρούσες συνθέσεις και μέθοδοι είναι σχετικά απλές, μπορούν να παραχθούν εύκολα, για παράδειγμα, χρησιμοποιώντας συνηθισμένες τεχνικές παραγωγής, και μπορούν να εφαρμοστούν εύκολα και βολικά, για παράδειγμα, χρησιμοποιώντας τεχνικές εφαρμογής ή χορήγησης ή μεθοδολογίες οι οποίες είναι σημαντικά παρεμφερείς με αυτές που εφαρμόστηκαν σε προηγούμενες συνθέσεις οι οποίες χρησιμοποιήθηκαν για τη θεραπεία της οφθαλμικής υπέρτασης.
CY20111100642T 2001-05-31 2011-07-04 Συνθεσεις υποτασικου λιπιδιου (προσταγλανδινης) και τιμολολης - σχετικες μεθοδοι χρησης CY1111872T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29484501P 2001-05-31 2001-05-31
EP02739579A EP1392319B1 (en) 2001-05-31 2002-05-30 Hypotensive lipid (prostaglandin) and timolol compositions and methods of using same

Publications (1)

Publication Number Publication Date
CY1111872T1 true CY1111872T1 (el) 2015-11-04

Family

ID=23135192

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100642T CY1111872T1 (el) 2001-05-31 2011-07-04 Συνθεσεις υποτασικου λιπιδιου (προσταγλανδινης) και τιμολολης - σχετικες μεθοδοι χρησης

Country Status (21)

Country Link
US (5) US8629140B2 (el)
EP (2) EP2272518A1 (el)
JP (2) JP4475871B2 (el)
KR (1) KR100891266B1 (el)
CN (1) CN100391461C (el)
AR (1) AR035248A1 (el)
AT (1) ATE506066T1 (el)
AU (1) AU2002312221B2 (el)
BR (1) BR0209709A (el)
CA (1) CA2445386C (el)
CY (1) CY1111872T1 (el)
DE (1) DE60239797D1 (el)
DK (1) DK1392319T3 (el)
EC (1) ECSP034815A (el)
ES (1) ES2363077T3 (el)
HK (1) HK1070830A1 (el)
MX (1) MXPA03010146A (el)
NZ (1) NZ528998A (el)
PT (1) PT1392319E (el)
TW (1) TWI298257B (el)
WO (1) WO2002096432A2 (el)

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US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
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AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
JP5982287B2 (ja) 2009-11-09 2016-08-31 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 発毛を刺激する組成物および方法
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Also Published As

Publication number Publication date
EP1392319A2 (en) 2004-03-03
US20150150880A1 (en) 2015-06-04
KR20040007577A (ko) 2004-01-24
MXPA03010146A (es) 2004-03-10
DK1392319T3 (da) 2011-06-27
NZ528998A (en) 2005-06-24
US8906907B2 (en) 2014-12-09
ES2363077T3 (es) 2011-07-20
PT1392319E (pt) 2011-06-28
ECSP034815A (es) 2004-07-23
CA2445386C (en) 2010-08-24
US10045997B2 (en) 2018-08-14
US20170112853A1 (en) 2017-04-27
JP2010031041A (ja) 2010-02-12
JP2004532870A (ja) 2004-10-28
ATE506066T1 (de) 2011-05-15
US20140051704A1 (en) 2014-02-20
CA2445386A1 (en) 2002-12-05
US20090181969A1 (en) 2009-07-16
AU2002312221B2 (en) 2007-02-15
JP4475871B2 (ja) 2010-06-09
US9474760B2 (en) 2016-10-25
DE60239797D1 (de) 2011-06-01
TWI298257B (en) 2008-07-01
WO2002096432A3 (en) 2003-05-08
US8629140B2 (en) 2014-01-14
EP2272518A1 (en) 2011-01-12
EP1392319B1 (en) 2011-04-20
US20030069286A1 (en) 2003-04-10
CN1543348A (zh) 2004-11-03
AR035248A1 (es) 2004-05-05
KR100891266B1 (ko) 2009-03-30
BR0209709A (pt) 2004-07-27
WO2002096432A2 (en) 2002-12-05
HK1070830A1 (en) 2005-06-30
US8618093B2 (en) 2013-12-31
CN100391461C (zh) 2008-06-04

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