KR100840213B1 - 본초 조성물 phy906 및 화학요법에서의 이의 용도 - Google Patents

본초 조성물 phy906 및 화학요법에서의 이의 용도 Download PDF

Info

Publication number
KR100840213B1
KR100840213B1 KR1020027011817A KR20027011817A KR100840213B1 KR 100840213 B1 KR100840213 B1 KR 100840213B1 KR 1020027011817 A KR1020027011817 A KR 1020027011817A KR 20027011817 A KR20027011817 A KR 20027011817A KR 100840213 B1 KR100840213 B1 KR 100840213B1
Authority
KR
South Korea
Prior art keywords
delete delete
phy906
cpt
treatment
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020027011817A
Other languages
English (en)
Korean (ko)
Other versions
KR20020086627A (ko
Inventor
쳉융-치
뤼쉬유-훼이
Original Assignee
예일 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 예일 유니버시티 filed Critical 예일 유니버시티
Publication of KR20020086627A publication Critical patent/KR20020086627A/ko
Application granted granted Critical
Publication of KR100840213B1 publication Critical patent/KR100840213B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020027011817A 2000-03-09 2001-03-08 본초 조성물 phy906 및 화학요법에서의 이의 용도 Expired - Lifetime KR100840213B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52205500A 2000-03-09 2000-03-09
US09/522,055 2000-03-09

Publications (2)

Publication Number Publication Date
KR20020086627A KR20020086627A (ko) 2002-11-18
KR100840213B1 true KR100840213B1 (ko) 2008-06-23

Family

ID=24079273

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027011817A Expired - Lifetime KR100840213B1 (ko) 2000-03-09 2001-03-08 본초 조성물 phy906 및 화학요법에서의 이의 용도

Country Status (13)

Country Link
US (1) US7025993B2 (https=)
EP (1) EP1401458B1 (https=)
JP (3) JP5064630B2 (https=)
KR (1) KR100840213B1 (https=)
CN (1) CN100490845C (https=)
AT (1) ATE494899T1 (https=)
AU (1) AU4550801A (https=)
CA (1) CA2402466C (https=)
DE (1) DE60143857D1 (https=)
DK (1) DK1401458T3 (https=)
ES (1) ES2358639T3 (https=)
TW (1) TWI324069B (https=)
WO (1) WO2001066123A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534455B2 (en) * 2000-03-09 2009-05-19 Yale University Herbal composition PHY906 and its use in chemotherapy
US8309141B2 (en) * 2000-03-09 2012-11-13 Yale University Herbal composition PHY906 and its use in chemotherapy
US8871279B2 (en) 2000-03-09 2014-10-28 Yale University Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen
ATE361746T1 (de) * 2002-03-06 2007-06-15 Medical Res And Education Trus Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin
RU2209062C1 (ru) * 2002-03-19 2003-07-27 Институт физиологии им. И.П.Павлова РАН Вещество, обладающее седативным действием
WO2005077370A1 (ja) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha カンプトテシン類含有水溶液製剤
US20110111070A1 (en) * 2007-10-25 2011-05-12 Yung-Chi Cheng Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome
US9778276B2 (en) * 2007-11-20 2017-10-03 Hewlett-Packard Development Company, L.P. Liquid handling device
KR100915457B1 (ko) * 2008-01-31 2009-09-04 세종대학교산학협력단 한국산 겨우살이 추출물이 함유된 미세캡슐을 유효성분으로포함하는 기능성 식품
TWI366466B (en) * 2008-05-08 2012-06-21 Ind Tech Res Inst Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof
WO2010035262A2 (en) * 2008-09-25 2010-04-01 Life Biotech Medical Research Ltd Herbal formulations
KR101138461B1 (ko) * 2010-02-12 2012-04-26 한국생명공학연구원 감초 추출물을 포함하는 로타바이러스 감염의 예방 또는 치료용 조성물
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US8597695B1 (en) 2010-11-13 2013-12-03 Sirbal Ltd. Herbal combinations for treatment of a skin condition
US20170049687A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
CN102716421A (zh) * 2012-06-21 2012-10-10 中国人民解放军第三军医大学第一附属医院 治疗扁平疣的中药口服液及其制备方法
CN102698068B (zh) * 2012-07-02 2013-07-24 张秀香 一种预防化疗所致口腔黏膜炎的口腔护理液制备方法
KR101350143B1 (ko) 2013-05-30 2014-01-16 재단법인 통합의료진흥원 반하 및 황금 생약 추출물을 포함하는 항암제로 인한 부작용의 경감용 조성물
EP3076984B1 (en) 2013-12-02 2018-11-14 Sirbal Ltd. Herbal combinations for treatment of a skin condition
WO2017034919A1 (en) * 2015-08-21 2017-03-02 The Methodist Hospital Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity
CN114668839A (zh) * 2016-05-23 2022-06-28 耶鲁大学 包含phy906提取物、黄芩提取物或来自这些提取物的化合物的联合疗法
SG11201901540UA (en) 2016-06-22 2019-04-29 Univ Yale Mechanism based quality control for botanical medicine
CN112040965B (zh) 2018-02-28 2023-04-14 中央大学校产学协力团 用于预防、减轻或治疗恶病质和肌肉损失的组合物
WO2019204471A1 (en) * 2018-04-20 2019-10-24 Yale University Treatment of hepatitis c
WO2020255133A1 (en) * 2019-06-18 2020-12-24 The Cures Ltd. Novel therapeutic preparations comprising scutellaria barbata
CN111011136B (zh) * 2019-11-13 2021-11-02 云南中烟新材料科技有限公司 一种假秦艽的人工种植方法
EP4087585A4 (en) * 2019-12-09 2023-12-06 Yale University COMPOSITIONS AND METHODS FOR PREVENTING CANCER RECURRENCE
JP2023545880A (ja) * 2020-03-30 2023-11-01 イエール ユニバーシティ 炎症性および線維性疾患および障害の処置法
CN114642732A (zh) * 2020-12-21 2022-06-21 苏州普瑞森生物科技有限公司 一种组合物及其在制备治疗肿瘤的药物中的应用
TW202337484A (zh) * 2022-03-01 2023-10-01 耶魯大學 用於調節t細胞之活化t細胞核因子(nfat)活性的組成物及方法
CN116712507B (zh) * 2023-08-10 2023-10-20 中国人民解放军总医院第六医学中心 一种辅助乳腺癌化疗的中药组合物及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936619A (ja) 1982-08-23 1984-02-28 Tsumura Juntendo Inc 制癌補助剤
JPS5936621A (ja) 1982-08-25 1984-02-28 Tsumura Juntendo Inc 脂肪分解促進作用阻害剤
US5437866A (en) 1989-11-03 1995-08-01 Sun; Alexander S. Herbal treatment of malignancy
US5665393A (en) 1996-09-03 1997-09-09 International Medical Research, Inc. Herbal composition for treating prostate carcinoma
US6048847A (en) 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gan To Kagaku Ryoho 25(8), 1159-63 (1998)
Jpn. J. Cancer Res. 86(10), 978-84 (1995)
Xenobiotica 23(1), 5-10 (1993)

Also Published As

Publication number Publication date
AU4550801A (en) 2001-09-17
JP5064630B2 (ja) 2012-10-31
JP2012167101A (ja) 2012-09-06
CA2402466C (en) 2014-11-18
CN100490845C (zh) 2009-05-27
DK1401458T3 (da) 2011-05-09
US20030211180A1 (en) 2003-11-13
CA2402466A1 (en) 2001-09-13
JP2014208684A (ja) 2014-11-06
EP1401458A2 (en) 2004-03-31
US7025993B2 (en) 2006-04-11
EP1401458B1 (en) 2011-01-12
ES2358639T3 (es) 2011-05-12
JP2004500390A (ja) 2004-01-08
DE60143857D1 (de) 2011-02-24
WO2001066123A2 (en) 2001-09-13
TWI324069B (en) 2010-05-01
WO2001066123A3 (en) 2004-01-08
CN1612743A (zh) 2005-05-04
ATE494899T1 (de) 2011-01-15
KR20020086627A (ko) 2002-11-18

Similar Documents

Publication Publication Date Title
KR100840213B1 (ko) 본초 조성물 phy906 및 화학요법에서의 이의 용도
AU2005304493B2 (en) Herbal composition PHY906 and its use in chemotherapy
Lin et al. Anti-inflammatory and hepatoprotective activity of peh-hue-juwa-chi-cao in male rats
MXPA03003446A (es) Nueva composicion herbacea medicinal para tratar enfermedades del higado y vih.
US20130101688A1 (en) Herbal composition phy906 and its use in chemotherapy
Liu et al. Challenges in research and development of traditional Chinese medicines
CN101342249B (zh) 一种治疗乙肝的中药制剂及其制备方法
AU2001245508B2 (en) Compositions consisting of PHY906 and chemotherapeutic agents
CN101062374B (zh) 一种治疗癌症的中药组合物胶囊的制备方法及其产品
HK1111910A (en) Herbal composition phy906 and its use in chemotherapy
CN118806832B (zh) 一种用于晚期原发性肝癌的中药组合物及其应用
CN102793767A (zh) 一种治疗失眠症的三七药物组合物及其制备方法与应用
Liu et al. Chinese medicinal plants
CN107569564A (zh) 一种艾滋病辅助治疗药物及其制备方法
CN104510912B (zh) 一种治疗气滞血瘀型慢性乙型肝炎的中药及制备方法
HK1077737A (en) Herbal composition phy906 and its use in chemotheraphy
CN114948873A (zh) 药物信息叠加扩增治疗系数的药物新制剂制备工艺与产品及用途
CN114404487A (zh) 黄根或其提取物在制备用于治疗胶质瘤的药物中的应用
Huang et al. Current studies of traditional Chinese medicine: A review
Kim et al. Hepatoprotective Activity of Chungpesagan-tang is Related to the Inhibition of ${\beta}-Glucuronidase$
CN103157063A (zh) 一种抑制肿瘤的中药复方制剂及其制备方法
CN103585239A (zh) 一种齿缘草提取物的制备方法及其应用

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20020909

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20060308

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20070321

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20071112

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20080417

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20080616

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20080617

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20110609

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20120605

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20130610

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20130610

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20140610

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20140610

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20150605

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20150605

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20160607

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20160607

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20170609

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20170609

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20190611

Year of fee payment: 12

PR1001 Payment of annual fee

Payment date: 20190611

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20200610

Start annual number: 13

End annual number: 13

PC1801 Expiration of term

Termination date: 20210908

Termination category: Expiration of duration