JP7132344B2 - 悪液質および筋損失の予防、改善または治療用組成物 - Google Patents
悪液質および筋損失の予防、改善または治療用組成物 Download PDFInfo
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Description
シャクヤク(Paeoniae Radix)250gと30%エタノール2Lを3Lの反応槽に入れて、還流抽出器を用いて65℃で4時間還流抽出した。1次抽出物をろ過し、残渣物に再度30%エタノール2Lを添加して、同じ条件で2次抽出した。以後、2次抽出物をろ過して1次抽出物と混合した後、50℃以下で濃縮してエタノールを除去した。濃縮された抽出物を凍結乾燥させた後、ミキサで砕いて均質化した。抽出物の製造結果、乾燥重量43g(収率17.20%)のシャクヤク抽出物を得ることができた。
2-1.実験動物の準備および実験方法
実験動物は4週齢の雄C57BL/6マウス(18~20g)で、中央実験動物(株)から供給されて実験動物飼育場で1週間適応させた後、実験に使用した。実験期間中、固形飼料と水は自由に摂取させ、飼育室の温度(22±2℃)、相対湿度(60±5%)と、明暗は12時間の周期を維持した。
腫瘍を誘導した後、14日間シャクヤク抽出物を経口投与しながらマウスの食事量を記録した。その結果、下記表1および図1Aと図5Aに開示されたように、腫瘍誘発群(対照群)対比のシャクヤク抽出物投与群で食事量が増加したことを確認することができた。下記表1中、*p<0.05;**p<0.01;および***p<0.001を示し、以下に記載の表および図面においても同じ意味で使用した。
腫瘍を誘導した後、14日間シャクヤク抽出物を経口投与した後、マウスを犠牲にして腫瘍の重量を確認した。その結果、下記表2および図1Bおよび図5Bに開示されたように、腫瘍誘発群(対照群)対比のシャクヤク抽出物投与群で有意な腫瘍の重量の変化は現れていないことが確認された。
腫瘍を誘導した後、14日間シャクヤク抽出物を経口投与した後、マウスを犠牲にして後ろ足筋肉の重量を確認した。その結果、下記表3および図1Cと図5Cに開示されたように、腫瘍誘発群(対照群)対比のシャクヤク抽出物投与群で有意な後ろ足筋肉の重量が増加したことが確認された。
腫瘍を誘導した後、14日間シャクヤク抽出物を経口投与した後、マウスを犠牲にして血清および筋肉内炎症性サイトカインの濃度を確認した。その結果、下記表4および図2と図8に開示されたように、正常群に比べて、対照群(腫瘍誘発群)で腫瘍によって炎症性サイトカインが増加し、対照群に比べて、シャクヤク抽出物投与群で有意に血清および筋肉内炎症性サイトカインが減少したことを確認して、シャクヤク抽出物の炎症および筋損失の改善効果を確認した。
腫瘍を誘導したマウスに既存の薬物またはシャクヤク抽出物を経口投与してから12日目に筋力(grip strength、g)および持久力(treadmill、sec)テストでマウスの筋力および持久力を確認した。測定結果、下記表5と表6および図3と図9に示すように、正常群と比較して、対照群では筋力および持久力が著しく減少したことを確認した。これに対し、対照群と比較して、シャクヤク抽出物投与群では筋力および持久力が有意に増加したことを確認して、腫瘍が誘導されたマウスの筋力および持久力が改善されたことが確認された。
腫瘍を誘導した後、14日間シャクヤク抽出物を経口投与した後、マウスを犠牲にしてLLC肺癌マウスの後ろ足筋肉内の筋肉分解因子(MAFbx)の減少効果を当業界で知られたウェスタンブロット(western blot)および免疫蛍光法(Immunofluorescence)を用いて測定した。測定結果、下記の図4に示すように、正常群と比較して、対照群では筋肉分解因子が著しく増加したことを確認した。これに対し、対照群と比較して、シャクヤク抽出物投与群では筋肉分解因子が有意に減少したことを確認した。
3-1.実験動物の準備
実験動物は4週齢の雄C57BL/6マウス(18~20g)で、中央実験動物(株)から供給されて実験動物飼育場で1週間適応させた後、実験に使用した。実験期間中、固形飼料と水は自由に摂取させ、飼育室の温度(22±2℃)、相対湿度(60±5%)と、明暗は12時間の周期を維持した。
5-FU投与後、7日間シャクヤク抽出物(500mg/kg)を経口投与しながらマウスの体重と食事量を記録した。その結果、下記表7および図11Aと図11Bに開示されたように、正常群と比較して、対照群では体重と食事量が有意に減少するが、シャクヤク抽出物投与群では体重と食事量が回復することを確認することができた。
実験が終了した後、マウスの大腿部で筋肉を分離し、筋肉に存在するグリコーゲン成分(muscleglycogen)を当業界で知られた方法により測定した。
抗癌副作用を誘導したマウスにシャクヤク抽出物を経口投与してから6日目に強制遊泳試験でマウスの疲労度を確認し、マウス体重の5%程度を負荷した後、遊泳時間(swimming time)を測定した。
シャクヤク抽出物を7日間経口投与した後、マウスから血液を分離して血球分析器で分析した。分析結果、下記表10および図12に示すように、対照群(control)と比較して、シャクヤク抽出物投与群では白血球(white blood cell、WBC)およびリンパ球(lymphocyte)の数が有意に増加したことを確認することができた。また、シャクヤク抽出物投与群では、対照群と比較して血小板と赤血球数およびヘモグロビン数値が増加することが分かった。
Claims (7)
- シャクヤク(Paeoniae Radix)抽出物を唯一の有効成分として含む悪液質(cachexia)および筋損失の予防または治療用薬学的組成物。
- 前記シャクヤク抽出物は、蒸留水、C1~C4の低級アルコールおよびこれらの混合物からなる群より選択される溶媒でのシャクヤクからの溶媒抽出物である、請求項1に記載の悪液質および筋損失の予防または治療用薬学的組成物。
- 前記悪液質は、癌によって誘発されるものである、請求項1に記載の悪液質および筋損失の予防または治療用薬学的組成物。
- 前記悪液質は、抗癌剤によって誘発されるものである、請求項1に記載の悪液質および筋損失の予防または治療用薬学的組成物。
- 前記組成物は、食欲減少、体重減少、疲労度増加、炎症増加、筋肉損失および造血毒性からなる群より選択される症状を改善するものである、請求項1に記載の悪液質および筋損失の予防または治療用薬学的組成物。
- シャクヤク(Paeoniae Radix)抽出物を唯一の有効成分として含む悪液質および筋損失の予防または改善用食品組成物。
- 請求項1に記載の組成物を有効成分として含む、悪液質および筋損失の予防または治療用の抗癌補助剤。
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