KR100837715B1 - 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법 - Google Patents

인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법 Download PDF

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Publication number
KR100837715B1
KR100837715B1 KR1020077006991A KR20077006991A KR100837715B1 KR 100837715 B1 KR100837715 B1 KR 100837715B1 KR 1020077006991 A KR1020077006991 A KR 1020077006991A KR 20077006991 A KR20077006991 A KR 20077006991A KR 100837715 B1 KR100837715 B1 KR 100837715B1
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South Korea
Prior art keywords
alpha4
vla
antibody
integrin
antagonist
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Expired - Fee Related
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Korean (ko)
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KR20070050979A (ko
Inventor
필립 갓월스
로이 알. 로브
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바이오겐 아이덱 엠에이 인코포레이티드
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Publication of KR20070050979A publication Critical patent/KR20070050979A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020077006991A 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법 Expired - Fee Related KR100837715B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13084799P 1999-04-22 1999-04-22
US60/130,847 1999-04-22
US13721499P 1999-06-01 1999-06-01
US60/137,214 1999-06-01

Related Parent Applications (1)

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KR1020017013313A Division KR100746522B1 (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020077022430A Division KR20070102760A (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법

Publications (2)

Publication Number Publication Date
KR20070050979A KR20070050979A (ko) 2007-05-16
KR100837715B1 true KR100837715B1 (ko) 2008-06-13

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Application Number Title Priority Date Filing Date
KR1020077006991A Expired - Fee Related KR100837715B1 (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법
KR1020017013313A Expired - Fee Related KR100746522B1 (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법
KR1020077022430A Withdrawn KR20070102760A (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법

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KR1020017013313A Expired - Fee Related KR100746522B1 (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법
KR1020077022430A Withdrawn KR20070102760A (ko) 1999-04-22 2000-04-21 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법

Country Status (31)

Country Link
US (3) US6652856B2 (cg-RX-API-DMAC7.html)
EP (1) EP1173201B1 (cg-RX-API-DMAC7.html)
JP (3) JP5483515B2 (cg-RX-API-DMAC7.html)
KR (3) KR100837715B1 (cg-RX-API-DMAC7.html)
CN (3) CN100360183C (cg-RX-API-DMAC7.html)
AT (1) ATE298249T1 (cg-RX-API-DMAC7.html)
AU (1) AU783054B2 (cg-RX-API-DMAC7.html)
BG (2) BG65578B1 (cg-RX-API-DMAC7.html)
BR (1) BR0010669A (cg-RX-API-DMAC7.html)
CA (1) CA2370814C (cg-RX-API-DMAC7.html)
CY (1) CY1106046T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ301636B6 (cg-RX-API-DMAC7.html)
DE (1) DE60020955T2 (cg-RX-API-DMAC7.html)
DK (1) DK1173201T3 (cg-RX-API-DMAC7.html)
EA (1) EA006681B1 (cg-RX-API-DMAC7.html)
EE (1) EE05662B1 (cg-RX-API-DMAC7.html)
ES (1) ES2243259T3 (cg-RX-API-DMAC7.html)
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IL (5) IL145898A0 (cg-RX-API-DMAC7.html)
IS (1) IS2259B (cg-RX-API-DMAC7.html)
MX (1) MXPA01010612A (cg-RX-API-DMAC7.html)
NO (1) NO330221B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ515053A (cg-RX-API-DMAC7.html)
PL (1) PL198975B1 (cg-RX-API-DMAC7.html)
PT (1) PT1173201E (cg-RX-API-DMAC7.html)
RS (2) RS20080471A (cg-RX-API-DMAC7.html)
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WO2008011216A2 (en) 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
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CN120022360A (zh) 2019-08-28 2025-05-23 中外制药株式会社 跨物种抗潜伏TGF-β1抗体和使用方法
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BR0010669A (pt) 2002-02-19
IL182908A (en) 2010-11-30
IS2259B (is) 2007-06-15
HUP0201015A3 (en) 2004-12-28
KR100746522B1 (ko) 2007-08-07
IL206830A0 (en) 2010-12-30
US20050281818A1 (en) 2005-12-22
WO2000064474A8 (en) 2001-04-05
NZ541431A (en) 2008-01-31
KR20070050979A (ko) 2007-05-16
RS20080471A (sr) 2010-12-31
PT1173201E (pt) 2005-08-31
NO20015122D0 (no) 2001-10-19
HK1041452A1 (en) 2002-07-12
CA2370814A1 (en) 2000-11-02
RS50086B (sr) 2009-01-22
DE60020955T2 (de) 2006-05-11
HUP0201015A2 (hu) 2002-07-29
EP1173201A1 (en) 2002-01-23
MXPA01010612A (es) 2003-09-04
KR20070102760A (ko) 2007-10-19
CN100360183C (zh) 2008-01-09
CZ20013754A3 (cs) 2002-07-17
JP2007182453A (ja) 2007-07-19
EE200100549A (et) 2002-12-16
DE60020955D1 (de) 2005-07-28
PL198975B1 (pl) 2008-08-29
IS6105A (is) 2001-10-11
PL351916A1 (en) 2003-06-30
CN1356911A (zh) 2002-07-03
ATE298249T1 (de) 2005-07-15
US6652856B2 (en) 2003-11-25
BG110115A (en) 2008-12-30
NZ515053A (en) 2004-02-27
IL145898A0 (en) 2002-07-25
IL145898A (en) 2007-07-24
IL206829A (en) 2013-06-27
EA200101116A1 (ru) 2002-04-25
JP2014065747A (ja) 2014-04-17
AU4480000A (en) 2000-11-10
IL206829A0 (en) 2010-12-30
CZ301636B6 (cs) 2010-05-12
DK1173201T3 (da) 2005-09-12
EP1173201B1 (en) 2005-06-22
EA006681B1 (ru) 2006-02-24
IL206830A (en) 2013-06-27
CA2370814C (en) 2010-07-06
NO330221B1 (no) 2011-03-07
CN1332714C (zh) 2007-08-22
SK15202001A3 (sk) 2002-09-10
US20020182213A1 (en) 2002-12-05
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HU226383B1 (hu) 2008-10-28
WO2000064474A1 (en) 2000-11-02
BG65578B1 (bg) 2009-01-30
BG106118A (en) 2002-05-31
KR20020000221A (ko) 2002-01-05
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CN1596979A (zh) 2005-03-23
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JP2002542300A (ja) 2002-12-10
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HK1076379A1 (zh) 2006-01-20
BG66149B1 (bg) 2011-08-31
JP5483515B2 (ja) 2014-05-07
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