KR100836323B1 - 4-(17α-치환된-3-옥소에스트라-4,9-디엔-11β-일)벤즈알데히드-(1Ｅ 또는 1Ｚ)-옥심의 제조 방법 - Google Patents

4-(17α-치환된-3-옥소에스트라-4,9-디엔-11β-일)벤즈알데히드-(1Ｅ 또는 1Ｚ)-옥심의 제조 방법 Download PDF

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Publication number
KR100836323B1
KR100836323B1 KR1020037006317A KR20037006317A KR100836323B1 KR 100836323 B1 KR100836323 B1 KR 100836323B1 KR 1020037006317 A KR1020037006317 A KR 1020037006317A KR 20037006317 A KR20037006317 A KR 20037006317A KR 100836323 B1 KR100836323 B1 KR 100836323B1
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South Korea
Prior art keywords
formula
benzaldehyde
oxoestra
oxime
group
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Expired - Fee Related
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KR1020037006317A
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English (en)
Korean (ko)
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KR20030081330A (ko
Inventor
게르드 슈베르트
스벤 링
베른드 에르하르트
Original Assignee
바이엘 쉐링 파마 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Studio Devices (AREA)
KR1020037006317A 2000-11-10 2001-11-09 4-(17α-치환된-3-옥소에스트라-4,9-디엔-11β-일)벤즈알데히드-(1Ｅ 또는 1Ｚ)-옥심의 제조 방법 Expired - Fee Related KR100836323B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10056676A DE10056676A1 (de) 2000-11-10 2000-11-10 Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
DE10056676.6 2000-11-10
PCT/DE2001/004218 WO2002038582A2 (de) 2000-11-10 2001-11-09 Verfahren zur herstellung von 4-(17alpha-(substituierten-methyl)-3-oxoestra-4,9 dien-11-yl)benzaldehyd-(1e oder 1z)-oximen

Publications (2)

Publication Number Publication Date
KR20030081330A KR20030081330A (ko) 2003-10-17
KR100836323B1 true KR100836323B1 (ko) 2008-06-09

Family

ID=7663441

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037006317A Expired - Fee Related KR100836323B1 (ko) 2000-11-10 2001-11-09 4-(17α-치환된-3-옥소에스트라-4,9-디엔-11β-일)벤즈알데히드-(1Ｅ 또는 1Ｚ)-옥심의 제조 방법

Country Status (25)

Country Link
US (1) US7214808B2 (https=)
EP (1) EP1339734B1 (https=)
JP (1) JP4263478B2 (https=)
KR (1) KR100836323B1 (https=)
CN (1) CN100368427C (https=)
AT (1) ATE337328T1 (https=)
AU (2) AU2002216911B2 (https=)
BG (1) BG107886A (https=)
BR (1) BR0115249A (https=)
CA (1) CA2427632C (https=)
CZ (1) CZ301425B6 (https=)
DE (2) DE10056676A1 (https=)
EA (1) EA005530B1 (https=)
EE (1) EE200300222A (https=)
HR (1) HRP20030458A2 (https=)
HU (1) HUP0301765A2 (https=)
IL (2) IL155680A0 (https=)
MX (1) MXPA03004109A (https=)
NO (1) NO20032080D0 (https=)
NZ (1) NZ525962A (https=)
PL (1) PL205091B1 (https=)
SK (1) SK286601B6 (https=)
WO (1) WO2002038582A2 (https=)
YU (1) YU34303A (https=)
ZA (1) ZA200304480B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018888A1 (de) * 2006-04-18 2007-10-25 Bayer Schering Pharma Ag Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
JP4843372B2 (ja) * 2006-05-09 2011-12-21 株式会社リコー 画像処理装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648778A2 (de) * 1993-09-20 1995-04-19 JENAPHARM GmbH Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332284C2 (de) * 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648778A2 (de) * 1993-09-20 1995-04-19 JENAPHARM GmbH Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Tetrahedron Letters, Vol. 23(51), 1982, pages 5459-5462
Tetrahedron, Vol. 46(24), 1990, pages 8075-8082

Also Published As

Publication number Publication date
BR0115249A (pt) 2003-08-12
AU2002216911C1 (en) 2002-05-21
NO20032080L (no) 2003-05-09
US7214808B2 (en) 2007-05-08
WO2002038582A3 (de) 2002-09-12
WO2002038582A2 (de) 2002-05-16
DE50110829D1 (de) 2006-10-05
US20040053905A1 (en) 2004-03-18
CA2427632C (en) 2010-01-26
AU1691102A (en) 2002-05-21
AU2002216911B2 (en) 2007-06-14
EA200300506A1 (ru) 2003-12-25
IL155680A (en) 2009-06-15
ZA200304480B (en) 2004-08-24
JP2004513179A (ja) 2004-04-30
CZ301425B6 (cs) 2010-02-24
NO20032080D0 (no) 2003-05-09
CZ20031282A3 (cs) 2003-08-13
PL205091B1 (pl) 2010-03-31
PL361399A1 (en) 2004-10-04
ATE337328T1 (de) 2006-09-15
EP1339734B1 (de) 2006-08-23
JP4263478B2 (ja) 2009-05-13
CN1474829A (zh) 2004-02-11
CA2427632A1 (en) 2003-05-01
HUP0301765A2 (hu) 2003-09-29
DE10056676A1 (de) 2002-05-16
EE200300222A (et) 2003-08-15
SK5512003A3 (en) 2003-10-07
SK286601B6 (sk) 2009-02-05
YU34303A (sh) 2006-08-17
HRP20030458A2 (en) 2005-04-30
CN100368427C (zh) 2008-02-13
IL155680A0 (en) 2003-11-23
KR20030081330A (ko) 2003-10-17
NZ525962A (en) 2005-02-25
BG107886A (bg) 2004-02-27
HK1063187A1 (en) 2004-12-17
EA005530B1 (ru) 2005-04-28
EP1339734A2 (de) 2003-09-03
MXPA03004109A (es) 2004-07-08

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