HUP0301765A2 - Eljárás 4-(17alfa-szubtituált-3-oxoösztra-4,9-dién-11béta-il)-benzaldehid-(1E vagy 1Z)-oximok elżállítására - Google Patents

Eljárás 4-(17alfa-szubtituált-3-oxoösztra-4,9-dién-11béta-il)-benzaldehid-(1E vagy 1Z)-oximok elżállítására

Info

Publication number
HUP0301765A2
HUP0301765A2 HU0301765A HUP0301765A HUP0301765A2 HU P0301765 A2 HUP0301765 A2 HU P0301765A2 HU 0301765 A HU0301765 A HU 0301765A HU P0301765 A HUP0301765 A HU P0301765A HU P0301765 A2 HUP0301765 A2 HU P0301765A2
Authority
HU
Hungary
Prior art keywords
group
carbon atom
formula
alkyl radical
production
Prior art date
Application number
HU0301765A
Other languages
English (en)
Inventor
Bernd Erhart
Sven Ring
Gerd Schubert
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of HUP0301765A2 publication Critical patent/HUP0301765A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Studio Devices (AREA)

Abstract

Jelen találmány azon (I) általános képletű 4-(17a-szubsztituált-3oxoösztra-4,9-dién-11b-il)benxaldehid-(1E vagy 1Z)-oximok előállításimódszerére vonatkozik (II) általános képletű vegyületekből kiindulva,amelyekben R1 = H, 1-6 szénatomos alkil-gyök, vagy CnF2n+1 csoport, R21-4 szénatomos alkil-gyök, X E- vagy Z-OH-csoport, továbbá Y 1-6szénatomos O-alkilcsoport, vagy 1-6 szénatomos S-alkilcsoport, vagyolyan OCH2CnF2n+1-csoport, amelyben n 1, 2 vagy 3. Ó
HU0301765A 2000-11-10 2001-11-09 Eljárás 4-(17alfa-szubtituált-3-oxoösztra-4,9-dién-11béta-il)-benzaldehid-(1E vagy 1Z)-oximok elżállítására HUP0301765A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056676A DE10056676A1 (de) 2000-11-10 2000-11-10 Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
PCT/DE2001/004218 WO2002038582A2 (de) 2000-11-10 2001-11-09 Verfahren zur herstellung von 4-(17alpha-(substituierten-methyl)-3-oxoestra-4,9 dien-11-yl)benzaldehyd-(1e oder 1z)-oximen

Publications (1)

Publication Number Publication Date
HUP0301765A2 true HUP0301765A2 (hu) 2003-09-29

Family

ID=7663441

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301765A HUP0301765A2 (hu) 2000-11-10 2001-11-09 Eljárás 4-(17alfa-szubtituált-3-oxoösztra-4,9-dién-11béta-il)-benzaldehid-(1E vagy 1Z)-oximok elżállítására

Country Status (26)

Country Link
US (1) US7214808B2 (hu)
EP (1) EP1339734B1 (hu)
JP (1) JP4263478B2 (hu)
KR (1) KR100836323B1 (hu)
CN (1) CN100368427C (hu)
AT (1) ATE337328T1 (hu)
AU (2) AU1691102A (hu)
BG (1) BG107886A (hu)
BR (1) BR0115249A (hu)
CA (1) CA2427632C (hu)
CZ (1) CZ301425B6 (hu)
DE (2) DE10056676A1 (hu)
EA (1) EA005530B1 (hu)
EE (1) EE200300222A (hu)
HK (1) HK1063187A1 (hu)
HR (1) HRP20030458A2 (hu)
HU (1) HUP0301765A2 (hu)
IL (2) IL155680A0 (hu)
MX (1) MXPA03004109A (hu)
NO (1) NO20032080L (hu)
NZ (1) NZ525962A (hu)
PL (1) PL205091B1 (hu)
SK (1) SK286601B6 (hu)
WO (1) WO2002038582A2 (hu)
YU (1) YU34303A (hu)
ZA (1) ZA200304480B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018888A1 (de) * 2006-04-18 2007-10-25 Bayer Schering Pharma Ag Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
JP4843372B2 (ja) * 2006-05-09 2011-12-21 株式会社リコー 画像処理装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332284C2 (de) * 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds

Also Published As

Publication number Publication date
EA005530B1 (ru) 2005-04-28
WO2002038582A2 (de) 2002-05-16
ATE337328T1 (de) 2006-09-15
ZA200304480B (en) 2004-08-24
WO2002038582A3 (de) 2002-09-12
EE200300222A (et) 2003-08-15
CZ20031282A3 (cs) 2003-08-13
BR0115249A (pt) 2003-08-12
EA200300506A1 (ru) 2003-12-25
JP2004513179A (ja) 2004-04-30
EP1339734B1 (de) 2006-08-23
AU2002216911B2 (en) 2007-06-14
US7214808B2 (en) 2007-05-08
NO20032080D0 (no) 2003-05-09
CN100368427C (zh) 2008-02-13
AU2002216911C1 (en) 2002-05-21
PL361399A1 (en) 2004-10-04
PL205091B1 (pl) 2010-03-31
EP1339734A2 (de) 2003-09-03
SK286601B6 (sk) 2009-02-05
BG107886A (bg) 2004-02-27
HRP20030458A2 (en) 2005-04-30
IL155680A0 (en) 2003-11-23
CZ301425B6 (cs) 2010-02-24
MXPA03004109A (es) 2004-07-08
YU34303A (sh) 2006-08-17
US20040053905A1 (en) 2004-03-18
KR20030081330A (ko) 2003-10-17
NZ525962A (en) 2005-02-25
DE50110829D1 (de) 2006-10-05
CA2427632A1 (en) 2003-05-01
NO20032080L (no) 2003-05-09
IL155680A (en) 2009-06-15
HK1063187A1 (en) 2004-12-17
CA2427632C (en) 2010-01-26
SK5512003A3 (en) 2003-10-07
DE10056676A1 (de) 2002-05-16
AU1691102A (en) 2002-05-21
JP4263478B2 (ja) 2009-05-13
CN1474829A (zh) 2004-02-11
KR100836323B1 (ko) 2008-06-09

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees