ATE401407T1 - Verfahren zur herstellung von cytosin- nukleosidverbindungen - Google Patents

Verfahren zur herstellung von cytosin- nukleosidverbindungen

Info

Publication number
ATE401407T1
ATE401407T1 AT02253075T AT02253075T ATE401407T1 AT E401407 T1 ATE401407 T1 AT E401407T1 AT 02253075 T AT02253075 T AT 02253075T AT 02253075 T AT02253075 T AT 02253075T AT E401407 T1 ATE401407 T1 AT E401407T1
Authority
AT
Austria
Prior art keywords
cytosine
producing
cytosine nucleoside
nucleoside compounds
product
Prior art date
Application number
AT02253075T
Other languages
English (en)
Inventor
Tadashi Araki
Ichirou Ikeda
Kaori Matoishi
Reiko Abe
Toshihiro Oikawa
Yasuko Matsuba
Hiroki Ishibashi
Kiyoteru Nagahara
Yasushi Fukuiri
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of ATE401407T1 publication Critical patent/ATE401407T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
AT02253075T 2001-05-01 2002-05-01 Verfahren zur herstellung von cytosin- nukleosidverbindungen ATE401407T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001134352 2001-05-01

Publications (1)

Publication Number Publication Date
ATE401407T1 true ATE401407T1 (de) 2008-08-15

Family

ID=34131298

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02253075T ATE401407T1 (de) 2001-05-01 2002-05-01 Verfahren zur herstellung von cytosin- nukleosidverbindungen

Country Status (8)

Country Link
US (2) US6858721B2 (de)
EP (1) EP1254959B1 (de)
KR (1) KR100476294B1 (de)
CN (1) CN100546997C (de)
AT (1) ATE401407T1 (de)
BR (1) BR0203343A (de)
CA (1) CA2380804A1 (de)
DE (1) DE60227595D1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238519C (zh) * 2000-11-06 2006-01-25 三井化学株式会社 核苷化合物的生产方法
CN103509837B (zh) * 2012-06-28 2016-03-09 张金荣 一种酶法复合化学法制备卡培他滨中间体2’，3’-二-o-乙酰基-5’-脱氧-5-氟胞苷的方法
CN103451255B (zh) * 2013-03-28 2016-03-16 南京工业大学 次黄嘌呤核苷酸的生产方法
EP2883959A1 (de) 2013-12-13 2015-06-17 Plasmia Biotech, S.L. Enzymatische Herstellung von Cytosin-Nukleosidanaloga
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
CN105087515B (zh) * 2015-09-10 2018-12-04 江南大学 一种嘌呤核苷磷酸化酶的制备方法及应用
KR101877120B1 (ko) * 2016-07-08 2018-07-11 에스티팜 주식회사 생물전환공정을 이용한 2'-데옥시시티딘의 제조방법
CN108265095B (zh) * 2017-12-13 2020-11-24 东莞理工学院 一种15n稳定性同位素标记5-甲基脱氧胞苷的制备方法
CN114107413B (zh) * 2021-11-03 2023-10-20 江苏香地化学有限公司 一种酶催化胞嘧啶生产胞苷的方法及应用
CN117106680B (zh) * 2022-05-17 2024-02-23 苏州华赛生物工程技术有限公司 一种生产胞嘧啶的重组微生物及方法
CN115011653A (zh) * 2022-07-12 2022-09-06 苏州华赛生物工程技术有限公司 一种生产2′-脱氧胞苷的重组微生物及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61135597A (ja) * 1984-12-06 1986-06-23 Takeda Chem Ind Ltd シチジンおよびデオキシシチジンの製造法
JPH0763385B2 (ja) 1987-07-17 1995-07-12 味の素株式会社 チミジンの製造方法
JPH0789948B2 (ja) 1987-08-28 1995-10-04 味の素株式会社 ２▲’▼−デオキシシチジンの製造方法
CA2028119C (en) * 1989-02-28 2000-05-16 Hiroshi Yamauchi Process for producing nucleosides
US5075225A (en) * 1989-04-06 1991-12-24 The Texas A&M University System Process for the enzymatic synthesis of nucleosides
JPH03127986A (ja) 1989-10-12 1991-05-31 Takara Shuzo Co Ltd 新規ヌクレオシドホスホリラーゼ
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
JP3864357B2 (ja) * 1997-08-04 2006-12-27 有機合成薬品工業株式会社 プリンヌクレオシド化合物の製造方法
JP3928676B2 (ja) 1997-11-14 2007-06-13 味の素株式会社 ２’−デオキシアデノシン、２’−デオキシグアノシンの製造法
CA2373189A1 (en) * 1999-05-13 2000-11-23 Mitsui Chemicals, Inc. Process for preparing nucleoside compound
ATE431416T1 (de) * 1999-08-20 2009-05-15 Pasteur Institut Enzymatische synthese von deoxyribonucleotiden

Also Published As

Publication number Publication date
EP1254959B1 (de) 2008-07-16
CA2380804A1 (en) 2002-11-01
DE60227595D1 (de) 2008-08-28
KR20020085798A (ko) 2002-11-16
US20050233420A1 (en) 2005-10-20
BR0203343A (pt) 2003-06-10
EP1254959A2 (de) 2002-11-06
KR100476294B1 (ko) 2005-03-16
CN100546997C (zh) 2009-10-07
US6858721B2 (en) 2005-02-22
US7629457B2 (en) 2009-12-08
EP1254959A3 (de) 2003-07-09
US20030207405A1 (en) 2003-11-06
CN1392153A (zh) 2003-01-22

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