BR0115249A - Processo para a produção de 4-(3-oxoestra-4,9-dien-11beta-il-17alfa-substituìda)be nzaldeìdo-(1e ou 1z)-oximas - Google Patents
Processo para a produção de 4-(3-oxoestra-4,9-dien-11beta-il-17alfa-substituìda)be nzaldeìdo-(1e ou 1z)-oximasInfo
- Publication number
- BR0115249A BR0115249A BR0115249-1A BR0115249A BR0115249A BR 0115249 A BR0115249 A BR 0115249A BR 0115249 A BR0115249 A BR 0115249A BR 0115249 A BR0115249 A BR 0115249A
- Authority
- BR
- Brazil
- Prior art keywords
- oxoestra
- 11beta
- dien
- substituted
- 17alpha
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 title 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Epoxy Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Studio Devices (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"PROCESSO PARA A PRODUçãO DE 4-(3-OXOESTRA-4,9-DIEN-11BETA-IL-17ALFA-SUBSTITUìDA)BE NZALDEìDO-(1E OU 1Z)-OXIMAS". A invenção refere-se a um método para a produção de 4-(3-oxoestra-4,9-dien-11beta-il-17alfa-substituída)benzaldeído-(1E ou 1Z)oximas? da fórmula geral (I), onde R~ 1~ = H, C~ 1~-C~ 6~ alquila ou um grupo de C~ n~F~ 2n+1~, R~ 2~ = C~ 1~-C~ 4~ alquila, X = E-ou Z-OH; e Y = O-C~ 1-6~ alquila, S-C~ 1-6~ alquila ou O-CH~ 2~C~ n~F~ 2n+1~, onde n = 1, 2 ou 3, que produz os compostos alvo da fórmula (I) com alto rendimento e seletividade.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10056676A DE10056676A1 (de) | 2000-11-10 | 2000-11-10 | Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen |
| PCT/DE2001/004218 WO2002038582A2 (de) | 2000-11-10 | 2001-11-09 | Verfahren zur herstellung von 4-(17alpha-(substituierten-methyl)-3-oxoestra-4,9 dien-11-yl)benzaldehyd-(1e oder 1z)-oximen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0115249A true BR0115249A (pt) | 2003-08-12 |
Family
ID=7663441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0115249-1A BR0115249A (pt) | 2000-11-10 | 2001-11-09 | Processo para a produção de 4-(3-oxoestra-4,9-dien-11beta-il-17alfa-substituìda)be nzaldeìdo-(1e ou 1z)-oximas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7214808B2 (pt) |
| EP (1) | EP1339734B1 (pt) |
| JP (1) | JP4263478B2 (pt) |
| KR (1) | KR100836323B1 (pt) |
| CN (1) | CN100368427C (pt) |
| AT (1) | ATE337328T1 (pt) |
| AU (2) | AU1691102A (pt) |
| BG (1) | BG107886A (pt) |
| BR (1) | BR0115249A (pt) |
| CA (1) | CA2427632C (pt) |
| CZ (1) | CZ301425B6 (pt) |
| DE (2) | DE10056676A1 (pt) |
| EA (1) | EA005530B1 (pt) |
| EE (1) | EE200300222A (pt) |
| HK (1) | HK1063187A1 (pt) |
| HR (1) | HRP20030458A2 (pt) |
| HU (1) | HUP0301765A2 (pt) |
| IL (2) | IL155680A0 (pt) |
| MX (1) | MXPA03004109A (pt) |
| NO (1) | NO20032080L (pt) |
| NZ (1) | NZ525962A (pt) |
| PL (1) | PL205091B1 (pt) |
| SK (1) | SK286601B6 (pt) |
| WO (1) | WO2002038582A2 (pt) |
| YU (1) | YU34303A (pt) |
| ZA (1) | ZA200304480B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006018888A1 (de) * | 2006-04-18 | 2007-10-25 | Bayer Schering Pharma Ag | Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil) |
| JP4843372B2 (ja) * | 2006-05-09 | 2011-12-21 | 株式会社リコー | 画像処理装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4332284C2 (de) * | 1993-09-20 | 1997-05-28 | Jenapharm Gmbh | 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US5576310A (en) * | 1994-09-20 | 1996-11-19 | Jenapharm Gmbh | 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds |
-
2000
- 2000-11-10 DE DE10056676A patent/DE10056676A1/de not_active Withdrawn
-
2001
- 2001-11-09 BR BR0115249-1A patent/BR0115249A/pt not_active IP Right Cessation
- 2001-11-09 AU AU1691102A patent/AU1691102A/xx active Pending
- 2001-11-09 KR KR1020037006317A patent/KR100836323B1/ko not_active IP Right Cessation
- 2001-11-09 EA EA200300506A patent/EA005530B1/ru not_active IP Right Cessation
- 2001-11-09 AU AU2002216911A patent/AU2002216911B2/en not_active Ceased
- 2001-11-09 EP EP01993608A patent/EP1339734B1/de not_active Expired - Lifetime
- 2001-11-09 NZ NZ525962A patent/NZ525962A/en unknown
- 2001-11-09 EE EEP200300222A patent/EE200300222A/xx unknown
- 2001-11-09 PL PL361399A patent/PL205091B1/pl not_active IP Right Cessation
- 2001-11-09 AT AT01993608T patent/ATE337328T1/de not_active IP Right Cessation
- 2001-11-09 HU HU0301765A patent/HUP0301765A2/hu unknown
- 2001-11-09 US US10/416,029 patent/US7214808B2/en not_active Expired - Lifetime
- 2001-11-09 IL IL15568001A patent/IL155680A0/xx unknown
- 2001-11-09 DE DE50110829T patent/DE50110829D1/de not_active Expired - Lifetime
- 2001-11-09 CZ CZ20031282A patent/CZ301425B6/cs not_active IP Right Cessation
- 2001-11-09 CN CNB018186785A patent/CN100368427C/zh not_active Expired - Fee Related
- 2001-11-09 WO PCT/DE2001/004218 patent/WO2002038582A2/de active IP Right Grant
- 2001-11-09 MX MXPA03004109A patent/MXPA03004109A/es active IP Right Grant
- 2001-11-09 CA CA2427632A patent/CA2427632C/en not_active Expired - Lifetime
- 2001-11-09 JP JP2002541114A patent/JP4263478B2/ja not_active Expired - Fee Related
- 2001-11-09 SK SK551-2003A patent/SK286601B6/sk not_active IP Right Cessation
- 2001-11-09 YU YU34303A patent/YU34303A/sh unknown
-
2003
- 2003-04-30 IL IL155680A patent/IL155680A/en not_active IP Right Cessation
- 2003-05-09 NO NO20032080A patent/NO20032080L/no unknown
- 2003-06-06 HR HR20030458A patent/HRP20030458A2/hr not_active Application Discontinuation
- 2003-06-06 BG BG107886A patent/BG107886A/bg unknown
- 2003-06-09 ZA ZA200304480A patent/ZA200304480B/en unknown
-
2004
- 2004-08-10 HK HK04105980A patent/HK1063187A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20023189L (no) | Fremgangsmåte for fremstilling av tolterodin og analoger derav samt intermediater fremstilt ved fremgangsmåten | |
| BR0211704A (pt) | Processo para recuperar energia a partir de um gás | |
| BR0208067A (pt) | Processo para a redução da produção de água em poços de petróleo | |
| BR0007643A (pt) | Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina | |
| BR0116074B1 (pt) | processo para a separação de microesferas de vidro ocas de lamas que contêm as mesmas. | |
| BR9606981A (pt) | Processo para preparação de intermediários inibidores de protease retroviral | |
| PT92180A (pt) | Processo para a preparacao de novas mevalonolactonas do tipo tienopiridina e de composicoes farmaceuticas que as contem | |
| BR0316530A (pt) | Processo para purificar diacereìna | |
| PT1196383E (pt) | Processo para preparar o benzenosulfonato de amlodipina | |
| BR0115249A (pt) | Processo para a produção de 4-(3-oxoestra-4,9-dien-11beta-il-17alfa-substituìda)be nzaldeìdo-(1e ou 1z)-oximas | |
| BR9807988A (pt) | Processo para a preparação de um composto, e, composto. | |
| BR0008140A (pt) | Composição polifenólica, e, processo para controlar substâncias viscosas | |
| PT983999E (pt) | Processo para a producao de derivados amida e dos seus intermediarios | |
| BR9912870A (pt) | Processo para sìntese de derivados de (1h) - benzo (c)quinolizina-3-onas | |
| BR9917000A (pt) | Processo para preparar derivados dedesaza-adenosina n6-substituìda | |
| CY1110066T1 (el) | Διαδικασια για την παρασκευη ντουλοξετινης | |
| BR0014314A (pt) | Processo para derivados de ácido fenilacético | |
| BR0111317A (pt) | Processo para preparar compostos, composto, sistema de catalisador, e, usos de um composto e de um sistema de catalisador | |
| PT1289930E (pt) | Processo para produzir acido 5-aminosalicilico | |
| PT1252327E (pt) | Processo para a separacao enzimatica de racematos de derivados de aminometilaril-ciclo-hexanol | |
| BR9909151A (pt) | processos para preparação de intermediários | |
| BRPI0514313A (pt) | processo para sintetizar um composto, e, composto | |
| PT1001929E (pt) | Processo para o fabrico de acidos 3-ciano-2,4-di-halogeno-5-fluorobenzoicos | |
| DK0703237T3 (da) | Fremgangsmåde til fremstilling af thio-phospholipider af ether-typen | |
| BR9908511A (pt) | Processo para a preparação de um composto, e, composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |