CN100368427C - 制备4-(17α-取代的-3-氧代雌-4,9-二烯-11β-基)苯甲醛-(1E或1Z)-肟的方法 - Google Patents

制备4-(17α-取代的-3-氧代雌-4,9-二烯-11β-基)苯甲醛-(1E或1Z)-肟的方法 Download PDF

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Publication number
CN100368427C
CN100368427C CNB018186785A CN01818678A CN100368427C CN 100368427 C CN100368427 C CN 100368427C CN B018186785 A CNB018186785 A CN B018186785A CN 01818678 A CN01818678 A CN 01818678A CN 100368427 C CN100368427 C CN 100368427C
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CN
China
Prior art keywords
oxime
benzaldehyde
group
alkyl
dien
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018186785A
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English (en)
Chinese (zh)
Other versions
CN1474829A (zh
Inventor
格尔德·舒伯特
斯文·林
贝恩德·埃哈特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of CN1474829A publication Critical patent/CN1474829A/zh
Application granted granted Critical
Publication of CN100368427C publication Critical patent/CN100368427C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Studio Devices (AREA)
CNB018186785A 2000-11-10 2001-11-09 制备4-(17α-取代的-3-氧代雌-4,9-二烯-11β-基)苯甲醛-(1E或1Z)-肟的方法 Expired - Fee Related CN100368427C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056676A DE10056676A1 (de) 2000-11-10 2000-11-10 Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
DE10056676.6 2000-11-10

Publications (2)

Publication Number Publication Date
CN1474829A CN1474829A (zh) 2004-02-11
CN100368427C true CN100368427C (zh) 2008-02-13

Family

ID=7663441

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018186785A Expired - Fee Related CN100368427C (zh) 2000-11-10 2001-11-09 制备4-(17α-取代的-3-氧代雌-4,9-二烯-11β-基)苯甲醛-(1E或1Z)-肟的方法

Country Status (25)

Country Link
US (1) US7214808B2 (https=)
EP (1) EP1339734B1 (https=)
JP (1) JP4263478B2 (https=)
KR (1) KR100836323B1 (https=)
CN (1) CN100368427C (https=)
AT (1) ATE337328T1 (https=)
AU (2) AU2002216911B2 (https=)
BG (1) BG107886A (https=)
BR (1) BR0115249A (https=)
CA (1) CA2427632C (https=)
CZ (1) CZ301425B6 (https=)
DE (2) DE10056676A1 (https=)
EA (1) EA005530B1 (https=)
EE (1) EE200300222A (https=)
HR (1) HRP20030458A2 (https=)
HU (1) HUP0301765A2 (https=)
IL (2) IL155680A0 (https=)
MX (1) MXPA03004109A (https=)
NO (1) NO20032080D0 (https=)
NZ (1) NZ525962A (https=)
PL (1) PL205091B1 (https=)
SK (1) SK286601B6 (https=)
WO (1) WO2002038582A2 (https=)
YU (1) YU34303A (https=)
ZA (1) ZA200304480B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018888A1 (de) * 2006-04-18 2007-10-25 Bayer Schering Pharma Ag Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
JP4843372B2 (ja) * 2006-05-09 2011-12-21 株式会社リコー 画像処理装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648778A2 (de) * 1993-09-20 1995-04-19 JENAPHARM GmbH Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332284C2 (de) * 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648778A2 (de) * 1993-09-20 1995-04-19 JENAPHARM GmbH Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
BR0115249A (pt) 2003-08-12
KR100836323B1 (ko) 2008-06-09
AU2002216911C1 (en) 2002-05-21
NO20032080L (no) 2003-05-09
US7214808B2 (en) 2007-05-08
WO2002038582A3 (de) 2002-09-12
WO2002038582A2 (de) 2002-05-16
DE50110829D1 (de) 2006-10-05
US20040053905A1 (en) 2004-03-18
CA2427632C (en) 2010-01-26
AU1691102A (en) 2002-05-21
AU2002216911B2 (en) 2007-06-14
EA200300506A1 (ru) 2003-12-25
IL155680A (en) 2009-06-15
ZA200304480B (en) 2004-08-24
JP2004513179A (ja) 2004-04-30
CZ301425B6 (cs) 2010-02-24
NO20032080D0 (no) 2003-05-09
CZ20031282A3 (cs) 2003-08-13
PL205091B1 (pl) 2010-03-31
PL361399A1 (en) 2004-10-04
ATE337328T1 (de) 2006-09-15
EP1339734B1 (de) 2006-08-23
JP4263478B2 (ja) 2009-05-13
CN1474829A (zh) 2004-02-11
CA2427632A1 (en) 2003-05-01
HUP0301765A2 (hu) 2003-09-29
DE10056676A1 (de) 2002-05-16
EE200300222A (et) 2003-08-15
SK5512003A3 (en) 2003-10-07
SK286601B6 (sk) 2009-02-05
YU34303A (sh) 2006-08-17
HRP20030458A2 (en) 2005-04-30
IL155680A0 (en) 2003-11-23
KR20030081330A (ko) 2003-10-17
NZ525962A (en) 2005-02-25
BG107886A (bg) 2004-02-27
HK1063187A1 (en) 2004-12-17
EA005530B1 (ru) 2005-04-28
EP1339734A2 (de) 2003-09-03
MXPA03004109A (es) 2004-07-08

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Correct: Process for the preparation of 4- (17 alpha - substituted -3- oxo estradiol, -4,9-, diene, -11, beta - group) benzaldehyde - (1E or 1Z) - oxime

False: Process for the preparation of 4- (17 alpha - substituted -3-, oxidation of female -4,9- diene -11 beta -) benzaldehyde - (1E or 1Z) - oxime

Number: 6

Volume: 20

CI02 Correction of invention patent application

Correction item: Denomination of Invention

Correct: Process for the preparation of 4- (17 alpha - substituted -3- oxo estradiol, -4,9-, diene, -11, beta - group) benzaldehyde - (1E or 1Z) - oxime

False: Process for the preparation of 4- (17 alpha - substituted -3-, oxidation of female -4,9- diene -11 beta -) benzaldehyde - (1E or 1Z) - oxime

Number: 6

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COR Change of bibliographic data

Free format text: CORRECT: INVENTION NAME; FROM: PREPARE 4-(17 A -SUBSTITUTED-3-OXIDE -4, 9-DIENE-11 - YL) BENZALDEHYDE -(1E OR 1Z)-OXIME METHOD TO: PREPARE 4-(17 A -SUBSTITUTED-3-FEMALE OXO -4, 9-DIENE-11 - YL) BENZALDEHYDE -(1E OR 1Z)-OXIME METHOD

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Free format text: CORRECT: INVENTION NAME; FROM: PREPARE 4-(17 A -SUBSTITUTED-3-OXIDE -4, 9-DIENE-11 - YL) BENZALDEHYDE -(1E OR 1Z)-OXIME METHOD TO: PREPARE 4-(17 A -SUBSTITUTED-3-FEMALE OXO -4, 9-DIENE-11 - YL) BENZALDEHYDE -(1E OR 1Z)-OXIME METHOD

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